Detailed information for compound 1879323

Basic information

Technical information
  • TDR Targets ID: 1879323
  • Name: 3-(benzimidazol-1-yl)-N-[[(E)-3-phenylprop-2- enylidene]amino]propanamide
  • MW: 318.372 | Formula: C19H18N4O
  • H donors: 1 H acceptors: 2 LogP: 2.68 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CCn1cnc2c1cccc2)N/N=C/C=C/c1ccccc1
  • InChi: 1S/C19H18N4O/c24-19(22-21-13-6-9-16-7-2-1-3-8-16)12-14-23-15-20-17-10-4-5-11-18(17)23/h1-11,13,15H,12,14H2,(H,22,24)/b9-6+,21-13+
  • InChiKey: ZIUGHJHEALPELP-YTJXIWKKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(benzimidazol-1-yl)-N-(3-phenylprop-2-enylideneamino)propanamide
  • 3-(1-benzimidazolyl)-N-[[(E)-3-phenylprop-2-enylidene]amino]propanamide
  • 3-(1-benzimidazolyl)-N-(3-phenylprop-2-enylideneamino)propanamide
  • 3-(benzimidazol-1-yl)-N-[[(E)-3-phenylprop-2-enylidene]amino]propionamide
  • 3-(benzimidazol-1-yl)-N-(3-phenylprop-2-enylideneamino)propionamide
  • SMR000433757
  • MLS000769035
  • 3-Benzoimidazol-1-yl-propionic acid [(E)-3-phenyl-prop-2-en-(E)-ylidene]-hydrazide
  • ST5054002

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0267 0.2253 0.2253
Echinococcus granulosus mitogen activated protein kinase 3 0.0072 0.032 0.032
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.006 0.0209 0.0254
Entamoeba histolytica protein kinase, putative 0.0112 0.0719 0.3073
Echinococcus multilocularis fibroblast growth factor receptor 4 0.024 0.1987 0.2411
Entamoeba histolytica p21-activated kinase 0.008 0.0401 0.1658
Plasmodium vivax calcium-dependent protein kinase, putative 0.0042 0.0029 0.0005
Entamoeba histolytica protein kinase, putative 0.0042 0.0029 0.0002
Echinococcus multilocularis aurora kinase A 0.0136 0.096 0.1165
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.0786 0.337
Echinococcus multilocularis serine:threonine protein kinase 0.0104 0.0635 0.0771
Schistosoma mansoni protein kinase 0.0074 0.0344 0.0594
Schistosoma mansoni serine/threonine protein kinase 0.0325 0.2822 0.4875
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0297 0.1231
Trypanosoma cruzi casein kinase, putative 0.0058 0.0186 0.081
Brugia malayi Protein kinase domain containing protein 0.027 0.2277 0.2472
Echinococcus multilocularis protein kinase shaggy 0.0119 0.0786 0.0953
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0042 0.0029 0.0031
Loa Loa (eye worm) hypothetical protein 0.0064 0.0246 0.0267
Schistosoma mansoni nck2/grb4 0.0056 0.0165 0.0286
Brugia malayi Immunoglobulin I-set domain containing protein 0.0082 0.0421 0.0457
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0042 0.0029 0.0029
Brugia malayi Protein kinase domain containing protein 0.0179 0.1382 0.1499
Loa Loa (eye worm) hypothetical protein 0.0056 0.0162 0.0176
Trichomonas vaginalis AGC family protein kinase 0.027 0.2277 1
Echinococcus multilocularis casein kinase I alpha 0.0058 0.0186 0.0226
Echinococcus granulosus tyrosine protein kinase Src42A 0.0092 0.0526 0.0526
Brugia malayi map kinase activated protein kinase protein 2 0.0397 0.3538 0.384
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.032 0.1335
Leishmania major protein kinase A catalytic subunit isoform 1 0.006 0.0209 0.0813
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0056 0.0165 0.0179
Echinococcus multilocularis tyrosine protein kinase Src64B 0.015 0.1094 0.1327
Brugia malayi ephrin receptor 1 precursor 0.0064 0.0246 0.0266
Loa Loa (eye worm) AGC/PKN protein kinase 0.0134 0.0939 0.1019
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0134 0.0939 0.0939
Entamoeba histolytica protein kinase domain containing protein 0.0112 0.0719 0.3073
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0108 0.0684 0.2946
Brugia malayi C1-like domain containing protein 0.014 0.0995 0.108
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0051 0.0115 0.0386
Plasmodium falciparum calcium-dependent protein kinase 3 0.0042 0.0029 0.0005
Giardia lamblia Kinase, CMGC GSK 0.0119 0.0786 0.3406
Echinococcus granulosus cyclin dependent kinase 1 0.0108 0.0684 0.0684
Schistosoma mansoni tyrosine kinase 0.0088 0.0486 0.084
Brugia malayi MAP kinase sur-1 0.0072 0.032 0.0348
Trichomonas vaginalis AGC family protein kinase 0.0134 0.0939 0.4073
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0428 0.0739
Onchocerca volvulus 0.0086 0.0458 0.0883
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0428 0.0739
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0028 0.0049
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0457 0.4128 0.5008
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0073 0.033 0.1342
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0119 0.0786 0.0853
Schistosoma mansoni protein kinase 0.0042 0.0029 0.005
Echinococcus multilocularis casein kinase I alpha 0.0058 0.0186 0.0226
Echinococcus multilocularis serine:threonine protein kinase 0.0104 0.0635 0.0771
Schistosoma mansoni vav2 0.0073 0.033 0.057
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0121 0.0884
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0042 0.0028 0.0106
Echinococcus multilocularis epidermal growth factor receptor 0.0625 0.5788 0.7021
Echinococcus granulosus calcium activated potassium channel 0.0083 0.0428 0.0428
Echinococcus multilocularis mitogen activated protein kinase 14 0.0151 0.1102 0.1336
Echinococcus multilocularis Glutaredoxin protein 5 0.013 0.0894 0.1084
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0288 0.0497
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0635 0.2729
Trypanosoma cruzi cdc2-related kinase 1 0.0108 0.0684 0.3021
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0116 0.0763 0.0763
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0127 0.0863 0.7974
Echinococcus granulosus serine:threonine protein kinase 0.0104 0.0635 0.0635
Brugia malayi serine/threonine kinase 12 0.0136 0.096 0.1042
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0209 0.0361
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0042 0.0029 0.0002
Brugia malayi Protein kinase domain containing protein 0.0112 0.0719 0.0781
Loa Loa (eye worm) AGC/PKA protein kinase 0.006 0.0209 0.0227
Entamoeba histolytica protein kinase 2, putative 0.0148 0.1076 0.4658
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0119 0.0786 0.1358
Loa Loa (eye worm) CAMK/PKD protein kinase 0.014 0.0995 0.108
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.006 0.0209 0.0804
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0074 0.0344 0.0417
Echinococcus multilocularis PAK box P21 Rho binding 0.0051 0.0119 0.0145
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0067 0.0273 0.0331
Plasmodium falciparum casein kinase 2, alpha subunit 0.0089 0.049 0.4409
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.024 0.1987 0.1987
Onchocerca volvulus 0.0509 0.4646 0.9038
Brugia malayi Protein kinase domain containing protein 0.0063 0.0239 0.0259
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0267 0.2253 0.2733
Echinococcus granulosus protein kinase C gamma type 0.0177 0.1363 0.1363
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0684 0.2944
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0763 0.1319
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.006 0.0209 0.0209
Schistosoma mansoni growth factor receptor-bound protein 0.0056 0.0165 0.0286
Echinococcus multilocularis tyrosine protein kinase HCK 0.0094 0.0541 0.0656
Trichomonas vaginalis STE family protein kinase 0.0074 0.0344 0.1439
Trichomonas vaginalis AGC family protein kinase 0.027 0.2277 1
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0042 0.0027 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0939 0.1622
Echinococcus multilocularis 0.0182 0.1412 0.1712
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0158 0.0273
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.049 0.2086
Loa Loa (eye worm) hypothetical protein 0.0082 0.0421 0.0457
Trichomonas vaginalis CK1 family protein kinase 0.0058 0.0186 0.0742
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0042 0.0029 0.0005
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0119 0.0786 0.0953
Trichomonas vaginalis CK1 family protein kinase 0.0058 0.0186 0.0742
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0108 0.0684 0.0684
Entamoeba histolytica serine/threonine protein kinase, putative 0.0267 0.2253 0.9894
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0051 0.0115 0.0396
Echinococcus multilocularis nervana 2 0.013 0.0894 0.1084
Giardia lamblia Kinase, NEK 0.0127 0.0863 0.3754
Plasmodium vivax protein kinase Crk2 0.0108 0.0684 0.6259
Loa Loa (eye worm) TK protein kinase 0.0125 0.0846 0.0919
Echinococcus granulosus serine:threonine kinase SAD 1 0.0042 0.0028 0.0028
Echinococcus multilocularis nervana 2 0.013 0.0894 0.1084
Loa Loa (eye worm) hypothetical protein 0.0082 0.0421 0.0457
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0136 0.096 0.1165
Trypanosoma cruzi polo-like protein kinase, putative 0.0267 0.2253 1
Brugia malayi serine/threonine-protein kinase PAK 7 0.0227 0.1858 0.2016
Trichomonas vaginalis AGC family protein kinase 0.0136 0.096 0.4168
Leishmania major protein kinase, putative 0.0073 0.033 0.1356
Echinococcus granulosus tyrosine protein kinase shark 0.0063 0.0239 0.0239
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0213 0.1717 0.2083
Trypanosoma brucei protein kinase, putative 0.0051 0.0115 0.0386
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0058 0.0182 0.0198
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0267 0.2253 0.2446
Schistosoma mansoni serine/threonine protein kinase 0.0397 0.3538 0.6112
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0228 0.1868 0.2266
Loa Loa (eye worm) TK/ABL protein kinase 0.0281 0.2388 0.2592
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0042 0.0029 0.0031
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0148 0.1076 0.1305
Echinococcus multilocularis epidermal growth factor receptor 0.0407 0.3631 0.4404
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0684 0.1181
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0168 0.1269 0.1269
Schistosoma mansoni ephrin receptor 0.01 0.0596 0.103
Loa Loa (eye worm) acetyltransferase 0.0175 0.1342 0.1456
Loa Loa (eye worm) hypothetical protein 0.0079 0.0396 0.043
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0072 0.032 0.1313
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0073 0.033 0.1448
Brugia malayi Protein kinase domain containing protein 0.0454 0.4103 0.4454
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.006 0.0209 0.0804
Brugia malayi protein kinase C II. 0.0171 0.1306 0.1418
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0112 0.0719 0.3179
Trypanosoma brucei aurora B kinase 0.0136 0.096 0.4144
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0158 0.0171
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.032 0.1335
Loa Loa (eye worm) hypothetical protein 0.0042 0.0028 0.0031
Schistosoma mansoni serine/threonine-protein kinase 0.0154 0.1133 0.1957
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.1717 0.2967
Echinococcus multilocularis activin receptor type 0.0051 0.0115 0.014
Giardia lamblia Kinase, CMGC GSK 0.0119 0.0786 0.3406
Loa Loa (eye worm) hypothetical protein 0.0151 0.11 0.1194
Onchocerca volvulus 0.0058 0.0186 0.0355
Giardia lamblia Kinase, CMGC MAPK 0.0072 0.032 0.1313
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0078 0.0226
Brugia malayi Protein kinase domain containing protein 0.0183 0.1421 0.1542
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0151 0.1102 0.4879
Schistosoma mansoni kinase 0.0287 0.2445 0.4224
Entamoeba histolytica protein kinase, putative 0.0136 0.096 0.4144
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0067 0.0273 0.0296
Echinococcus multilocularis raf serine:threonine protein kinase 0.0068 0.0288 0.0349
Brugia malayi serine/threonine-protein kinase 6 0.0136 0.096 0.1042
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.1717 0.2967
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.032 0.2778 0.3015
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0042 0.0029 0.0029
Plasmodium falciparum protein kinase 5 0.0108 0.0684 0.6259
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Echinococcus granulosus fibroblast growth factor receptor 4 0.024 0.1987 0.1987
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0762 0.3292
Trypanosoma cruzi cdc2-related kinase 3 0.0108 0.0684 0.3021
Echinococcus multilocularis tyrosine protein kinase Src42A 0.015 0.1094 0.1327
Echinococcus multilocularis calcium activated potassium channel 0.0083 0.0428 0.0519
Brugia malayi Variant SH3 domain containing protein 0.0056 0.0165 0.0179
Entamoeba histolytica protein kinase , putative 0.0136 0.096 0.4144
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0505 0.0873
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0056 0.0165 0.0179
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0261 0.2191 0.2658
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.181 0.3128
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0042 0.0029 0.0035
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0116 0.0763 0.0926
Echinococcus multilocularis insulin receptor 0.0454 0.4103 0.4977
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0136 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.0121 0.0813 0.0882
Loa Loa (eye worm) hypothetical protein 0.0146 0.105 0.114
Giardia lamblia Kinase, CMGC CDK 0.0108 0.0684 0.2946
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0239 0.0259
Brugia malayi Immunoglobulin I-set domain containing protein 0.064 0.594 0.6447
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0042 0.0029 0.0035
Loa Loa (eye worm) hypothetical protein 0.0063 0.0239 0.0259
Toxoplasma gondii AGC kinase 0.0264 0.222 1
Trichomonas vaginalis AGC family protein kinase 0.027 0.2277 1
Echinococcus granulosus c-Jun N-terminal kinases 0.0261 0.2191 0.2191
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0041 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0025
Echinococcus granulosus tyrosine protein kinase Fyn 0.015 0.1094 0.1094
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0127 0.0863 0.3811
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0042 0.0029 0.0002
Echinococcus granulosus cyclin dependent kinase 5 0.0108 0.0684 0.0684
Echinococcus multilocularis tyrosine protein kinase Blk 0.0125 0.0846 0.1027
Brugia malayi Hr1 repeat family protein 0.0134 0.0939 0.1019
Brugia malayi Variant SH3 domain containing protein 0.0056 0.0165 0.0179
Echinococcus multilocularis Immunoglobulin 0.0079 0.0396 0.048
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0136 0.096 0.4144
Trypanosoma cruzi aurora B kinase, putative 0.0136 0.096 0.4251
Schistosoma mansoni growth factor receptor-bound protein 0.0056 0.0165 0.0286
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0154 0.1133 0.5017
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0143 0.1027 0.1115
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0186 0.145 0.1574
Brugia malayi intracellular kinase 0.0119 0.0786 0.0853
Echinococcus granulosus cyclin dependent kinase 0.0108 0.0684 0.0684
Echinococcus granulosus mitogen activated protein kinase 0.0072 0.032 0.032
Giardia lamblia Kinase, STE STE20 0.0074 0.0344 0.1419
Plasmodium falciparum casein kinase 1 0.0058 0.0186 0.1511
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0267 0.2253 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0585 0.0635
Plasmodium falciparum serine/threonine protein kinase, putative 0.0136 0.096 0.8898
Schistosoma mansoni serine/threonine protein kinase 0.0267 0.2253 0.3893
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0069 0.0297 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0222 0.181 0.2196
Schistosoma mansoni protein kinase 0.0089 0.049 0.0847
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0214 0.1726 0.2094
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0187 0.0323
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0158 0.0158
Loa Loa (eye worm) AUR protein kinase 0.0136 0.096 0.1042
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0042 0.0029 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0158 0.0192
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0108 0.0684 0.0742
Entamoeba histolytica protein kinase, putative 0.0058 0.0187 0.0705
Onchocerca volvulus Tyrosine kinase homolog 0.0559 0.514 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0072 0.032 0.0389
Schistosoma mansoni tyrosine kinase 0.0374 0.331 0.5719
Echinococcus multilocularis myotubularin protein 13 0.0042 0.0024 0.0029
Plasmodium falciparum NIMA related kinase 1 0.0127 0.0863 0.7974
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0072 0.032 0.1405
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.015 0.1094 0.1327
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0762 0.3292
Schistosoma mansoni protein kinase 0.0074 0.0344 0.0594
Echinococcus granulosus N chimaerin 0.0067 0.0273 0.0273
Trypanosoma cruzi cdc2-related kinase 3 0.0108 0.0684 0.3021
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0067 0.0273 0.0471
Loa Loa (eye worm) hypothetical protein 0.0086 0.0458 0.0497
Brugia malayi SRC-1 0.015 0.1094 0.1187
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0074 0.0344 0.0344
Echinococcus multilocularis myosin iiia 0.0073 0.033 0.04
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0253 0.2114 0.2295
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0209 0.0361
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0108 0.0684 0.0742
Plasmodium falciparum calcium-dependent protein kinase 2 0.0042 0.0029 0.0005
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0058 0.0186 0.0202
Echinococcus granulosus dual specificity 0.0112 0.0719 0.0719
Echinococcus granulosus casein kinase I alpha 0.0058 0.0186 0.0186
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.015 0.1094 0.1327
Brugia malayi Protein kinase domain containing protein 0.0083 0.0428 0.0464
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0058 0.0186 0.0202
Echinococcus multilocularis mitogen activated protein kinase 14 0.0151 0.1102 0.1336
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0266 0.1058
Echinococcus multilocularis mitogen activated protein kinase 0.0072 0.032 0.0389
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0116 0.0757 0.3266
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0136 0.096 0.4144
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.005 0.0106 0.0129
Echinococcus multilocularis dual specificity 0.0112 0.0719 0.0873
Trypanosoma brucei cdc2-related kinase 3 0.0108 0.0684 0.2915
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0119 0.0786 0.0786
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0239 0.0259
Trichomonas vaginalis CAMK family protein kinase 0.0267 0.2253 0.9895
Schistosoma mansoni serine/threonine protein kinase 0.0261 0.2191 0.3786
Entamoeba histolytica protein kinase, putative 0.027 0.2277 1
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0042 0.0027 0.0033
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0281 0.2388 0.2897
Schistosoma mansoni tyrosine kinase 0.015 0.1094 0.189
Loa Loa (eye worm) hypothetical protein 0.0125 0.0845 0.0917
Trichomonas vaginalis AGC family protein kinase 0.014 0.0996 0.4325
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0115 0.0386
Entamoeba histolytica protein kinase domain containing protein 0.0089 0.049 0.2054
Brugia malayi Protein kinase domain containing protein 0.0108 0.0684 0.0742
Echinococcus multilocularis casein kinase ii subunit alpha 0.0089 0.049 0.0595
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0397 0.3538 0.4291
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0222 0.181 0.181
Onchocerca volvulus 0.0063 0.0239 0.0457
Loa Loa (eye worm) AUR protein kinase 0.0136 0.096 0.1042
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0239 0.0259
Brugia malayi Tyrosine-protein kinase abl-1 0.0134 0.094 0.102
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0079 0.0396 0.0684
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.096 0.1659
Schistosoma mansoni tyrosine kinase 0.0063 0.0239 0.0413
Giardia lamblia Kinase, NEK 0.0127 0.0863 0.3754
Loa Loa (eye worm) hypothetical protein 0.0116 0.0759 0.0823
Loa Loa (eye worm) hypothetical protein 0.0086 0.0458 0.0497
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.006 0.0209 0.0825
Entamoeba histolytica protein kinase, putative 0.0136 0.096 0.4144
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0684 0.2944
Brugia malayi Protein kinase c protein 2 0.0097 0.0573 0.0622
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0029 0.0043
Trypanosoma cruzi polo-like protein kinase, putative 0.0267 0.2253 1
Giardia lamblia Kinase, AGC PKA 0.006 0.0209 0.0813
Trypanosoma cruzi casein kinase, putative 0.0058 0.0186 0.081
Trypanosoma cruzi Protein kinase B 0.0154 0.1133 0.5017
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0121 0.0422
Loa Loa (eye worm) hypothetical protein 0.0079 0.0396 0.043
Brugia malayi putative serine/threonine kinase SADA gamma 0.0042 0.0028 0.0031
Leishmania major protein kinase A catalytic subunit isoform 2 0.006 0.0209 0.0813
Echinococcus granulosus tyrosine kinase 0.0063 0.0239 0.0239
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0121 0.0451
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0042 0.0029 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.145 0.2506
Plasmodium vivax unspecified product 0.0089 0.049 0.4409
Loa Loa (eye worm) TK/EGFR protein kinase 0.0625 0.5788 0.6282
Echinococcus multilocularis NCK adaptor protein 0.0056 0.0165 0.0201
Echinococcus multilocularis ephrin type A receptor 4 A 0.01 0.0596 0.0723
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.006 0.0209 0.0911
Echinococcus granulosus serine:threonine protein kinase N2 0.0134 0.0939 0.0939
Echinococcus granulosus tyrosine protein kinase HCK 0.0094 0.0541 0.0541
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0079 0.0396 0.048
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1293 0.1293
Echinococcus multilocularis cyclin dependent kinase 5 0.0108 0.0684 0.0829
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0148 0.1076 0.4764
Plasmodium vivax casein kinase 1, putative 0.0058 0.0186 0.1511
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0125 0.0846 0.0846
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.006 0.0209 0.0911
Brugia malayi RhoGAP domain containing protein 0.0067 0.0273 0.0296
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0136 0.0953 0.1157
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0168 0.1269 0.1539
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0143 0.1027 0.1027
Schistosoma mansoni tyrosine kinase 0.0088 0.0486 0.084
Loa Loa (eye worm) AGC/PKA protein kinase 0.006 0.0209 0.0227
Echinococcus multilocularis Immunoglobulin 0.0079 0.0396 0.048
Onchocerca volvulus 0.0046 0.0063 0.0113
Onchocerca volvulus 0.0119 0.0786 0.1522
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0151 0.1102 0.4773
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0297 0.0513
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.049 0.2086
Loa Loa (eye worm) TK/KIN16 protein kinase 0.064 0.594 0.6447
Giardia lamblia Kinase, PLK 0.0267 0.2253 1
Brugia malayi phosphoinositide-dependent protein kinase I 0.0069 0.0297 0.0322
Echinococcus granulosus nervana 2 0.013 0.0894 0.0894
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Brugia malayi Protein kinase domain containing protein 0.0186 0.145 0.1574
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0074 0.0344 0.0417
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0058 0.0187 0.0187
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0108 0.0684 0.2991
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0028 0.0049
Schistosoma mansoni serine/threonine kinase 0.0083 0.0428 0.0739
Trypanosoma cruzi casein kinase, putative 0.0058 0.0186 0.081
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0209 0.0361
Echinococcus multilocularis tyrosine protein kinase Abl 0.0172 0.1308 0.1587
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0098 0.0585 0.0585
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0072 0.032 0.1405
Schistosoma mansoni tyrosine kinase 0.0407 0.3631 0.6273
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0194 0.1533 0.1859
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0042 0.0028 0.0106
Echinococcus multilocularis serine:threonine protein kinase N2 0.0134 0.0939 0.1139
Brugia malayi protein kinase C3,putative 0.0141 0.1008 0.1094
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0072 0.032 0.1299
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0089 0.049 0.4409
Echinococcus multilocularis tyrosine protein kinase Srms 0.0125 0.0846 0.1027
Brugia malayi Protein kinase domain containing protein 0.0134 0.0939 0.1019
Loa Loa (eye worm) hypothetical protein 0.0116 0.0759 0.0823
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.015 0.1094 0.1094
Echinococcus multilocularis tyrosine protein kinase Fyn 0.015 0.1094 0.1327
Echinococcus granulosus epidermal growth factor receptor 0.0407 0.3631 0.3631
Schistosoma mansoni hypothetical protein 0.0064 0.0246 0.0424
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0239 0.0259
Echinococcus multilocularis N chimaerin 0.0067 0.0273 0.0331
Echinococcus granulosus Protein kinase C brain isozyme 0.0213 0.1717 0.1717
Echinococcus multilocularis casein kinase I alpha 0.0058 0.0186 0.0226
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Entamoeba histolytica PH domain containing protein kinase, putative 0.0154 0.1133 0.4911
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Onchocerca volvulus 0.0063 0.0239 0.0457
Trichomonas vaginalis AGC family protein kinase 0.0136 0.096 0.4168
Trichomonas vaginalis AGC family protein kinase 0.0134 0.0939 0.4073
Schistosoma mansoni nephrin 0.0099 0.0594 0.1026
Brugia malayi Protein kinase domain containing protein 0.0069 0.0297 0.0322
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0134 0.0939 0.1139
Schistosoma mansoni ste20-related kinase 0.0199 0.1578 0.2727
Toxoplasma gondii casein kinase I 0.0058 0.0186 0.0722
Giardia lamblia Kinase, CMGC CDK 0.0108 0.0684 0.2946
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0042 0.0029 0.0035
Trypanosoma cruzi casein kinase, putative 0.0058 0.0186 0.081
Brugia malayi protein-tyrosine kinase 0.0125 0.0846 0.0919
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.049 0.2086
Loa Loa (eye worm) hypothetical protein 0.0146 0.105 0.114
Echinococcus granulosus tyrosine protein kinase Blk 0.0125 0.0846 0.0846
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0972 0.9214 1
Entamoeba histolytica protein kinase, putative 0.0058 0.0187 0.0705
Schistosoma mansoni protein kinase 0.0136 0.096 0.1659
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0072 0.032 0.1405
Echinococcus granulosus casein kinase I delta 0.0058 0.0186 0.0186
Trypanosoma cruzi casein kinase, putative 0.0058 0.0186 0.081
Onchocerca volvulus 0.0325 0.2822 0.5487
Trichomonas vaginalis STE family protein kinase 0.0074 0.0344 0.1439
Onchocerca volvulus 0.0063 0.0239 0.0457
Echinococcus granulosus insulin receptor 0.0454 0.4103 0.4103
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0297 0.1231
Entamoeba histolytica casein kinase, putative 0.0089 0.049 0.2054
Entamoeba histolytica cell division protein kinase 2, putative 0.0108 0.0684 0.2915
Loa Loa (eye worm) hypothetical protein 0.0082 0.0421 0.0457
Brugia malayi P38 map kinase family protein 2 0.0151 0.1102 0.1196
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0112 0.0719 0.0781
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0089 0.049 0.0532
Giardia lamblia Kinase, CK1 Casein kinase 0.0058 0.0186 0.0711
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0239 0.0259
Onchocerca volvulus 0.0067 0.0275 0.0528
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0136 0.096 0.4144
Loa Loa (eye worm) TK/INSR protein kinase 0.0454 0.4103 0.4454
Echinococcus granulosus serine/threonine protein kinase 0.0154 0.1133 0.1133
Trichomonas vaginalis STE family protein kinase 0.0074 0.0344 0.1439
Plasmodium falciparum calcium-dependent protein kinase 5 0.0042 0.0029 0.0005
Echinococcus multilocularis cyclin dependent kinase 1 0.0108 0.0684 0.0829
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0121 0.0451
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0786 0.3397
Echinococcus granulosus protein kinase shaggy 0.0119 0.0786 0.0786
Echinococcus multilocularis mitogen activated protein kinase 11 0.0151 0.1102 0.1336
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0457 0.4128 0.4128
Echinococcus multilocularis serine threonine protein kinase 0.0177 0.1363 0.1653
Trypanosoma brucei protein kinase, putative 0.0072 0.032 0.1299
Brugia malayi Kinase associated domain 1 family protein 0.0064 0.0246 0.0267
Echinococcus multilocularis protein kinase c iota type 0.0257 0.2153 0.2611
Echinococcus granulosus serine:threonine protein kinase 0.0104 0.0635 0.0635
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0112 0.0723 0.3122
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0148 0.1076 1
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Schistosoma mansoni tyrosine kinase 0.0454 0.4103 0.7089
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0136 0.096 0.8898
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0058 0.0187 0.0227
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.049 0.2086
Brugia malayi Immunoglobulin I-set domain containing protein 0.0258 0.2161 0.2345
Echinococcus granulosus tyrosine protein kinase Srms 0.0063 0.0239 0.0239
Loa Loa (eye worm) TK protein kinase 0.0094 0.0541 0.0587
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0763 0.1319
Echinococcus granulosus epidermal growth factor receptor 0.0625 0.5788 0.5788
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0041 0.0019 0.0065
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.006 0.0209 0.0209
Echinococcus multilocularis hypothetical protein 0.0064 0.0246 0.0298
Entamoeba histolytica protein kinase, putative 0.0119 0.0786 0.337
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0042 0.0029 0.0029
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0074 0.0344 0.0344
Trichomonas vaginalis STE family protein kinase 0.0051 0.0119 0.0444
Echinococcus granulosus mitogen activated protein kinase 11 0.0151 0.1102 0.1102
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.1533 0.2649
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0719 0.1243
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0186 0.145 0.1574
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0121 0.0422
Schistosoma mansoni serine/threonine-protein kinase 0.0154 0.1133 0.1957
Onchocerca volvulus 0.0127 0.087 0.1685
Trichomonas vaginalis CAMK family protein kinase 0.0267 0.2253 0.9895
Echinococcus granulosus tyrosine protein kinase Src64B 0.015 0.1094 0.1094
Brugia malayi Casein kinase II, alpha chain 0.0089 0.049 0.0532
Echinococcus multilocularis tyrosine protein kinase Fyn 0.015 0.1094 0.1327
Echinococcus granulosus tyrosine protein kinase Fyn 0.015 0.1094 0.1094
Schistosoma mansoni atypical protein kinase C 0.0263 0.2216 0.3828
Leishmania major protein kinase, putative 0.0051 0.0115 0.039
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0063 0.0239 0.0239
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0063 0.0239 0.029
Echinococcus granulosus Glutaredoxin protein 5 0.013 0.0894 0.0894
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0228 0.1868 0.1868
Entamoeba histolytica protein kinase, putative 0.0043 0.0042 0.0061
Trypanosoma cruzi cdc2-related kinase 1 0.0108 0.0684 0.3021
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0042 0.0029 0.0002
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0042 0.0029 0.0002
Brugia malayi Cam kinase protein 1 0.0042 0.0029 0.0031
Toxoplasma gondii CMGC kinase, CK2 family 0.0089 0.049 0.2107
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0162 0.0633
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0222 0.181 0.1965
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0143 0.1027 0.1246
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0428 0.0739
Echinococcus multilocularis casein kinase I delta 0.0058 0.0186 0.0226
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.1269 0.2192
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.013 0.0894 0.0894
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0083 0.0428 0.0464
Plasmodium falciparum glycogen synthase kinase 3 0.0119 0.0786 0.7235
Brugia malayi Variant SH3 domain containing protein 0.0067 0.0273 0.0296
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0239 0.0259
Echinococcus multilocularis growth factor receptor bound protein 2 0.0056 0.0165 0.0201
Echinococcus multilocularis neuroglian 0.0097 0.0569 0.069
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0119 0.0786 0.3406
Loa Loa (eye worm) AUR protein kinase 0.0136 0.096 0.1042
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0863 0.374
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0042 0.0028 0.0034
Echinococcus granulosus tyrosine kinase 0.0125 0.0846 0.0846
Brugia malayi hypothetical protein 0.0082 0.0421 0.0457
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0125 0.0846 0.1027
Trichomonas vaginalis AGC family protein kinase 0.0136 0.096 0.4168
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.049 0.2086
Echinococcus granulosus mitogen activated protein kinase 14 0.0151 0.1102 0.1102
Plasmodium vivax glycogen synthase kinase 3, putative 0.0119 0.0786 0.7235
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.006 0.0209 0.0804
Echinococcus multilocularis mitogen activated protein kinase 11 0.0151 0.1102 0.1336
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0171 0.1306 0.1418
Trichomonas vaginalis CAMK family protein kinase 0.0267 0.2253 0.9895
Trichomonas vaginalis STE family protein kinase 0.0073 0.033 0.1377
Loa Loa (eye worm) hypothetical protein 0.0042 0.0029 0.0031
Brugia malayi Protein kinase domain containing protein 0.0063 0.0239 0.0259
Giardia lamblia Kinase, AGC AKT 0.0107 0.0666 0.2866
Brugia malayi Protein kinase domain containing protein 0.0972 0.9214 1
Echinococcus granulosus nervana 2 0.013 0.0894 0.0894
Echinococcus multilocularis serine:threonine protein kinase N2 0.0134 0.0939 0.1139
Loa Loa (eye worm) hypothetical protein 0.006 0.0209 0.0227
Echinococcus granulosus tyrosine protein kinase Lyn 0.0168 0.1276 0.1276
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0092 0.0526 0.0638
Leishmania major casein kinase, putative 0.0058 0.0186 0.0711
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0088 0.0486 0.084
Brugia malayi Protein kinase domain 0.0074 0.0344 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0684 0.1181
Entamoeba histolytica protein kinase, putative 0.0049 0.01 0.032
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0042 0.0023 0.0028
Toxoplasma gondii AGC kinase 0.006 0.0209 0.0825
Loa Loa (eye worm) hypothetical protein 0.0181 0.1405 0.1525
Loa Loa (eye worm) hypothetical protein 0.009 0.0502 0.0544
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0689
Schistosoma mansoni tyrosine kinase 0.0069 0.0296 0.0511
Trichomonas vaginalis STE family protein kinase 0.0127 0.0863 0.374
Trichomonas vaginalis CAMK family protein kinase 0.0267 0.2253 0.9895
Trypanosoma brucei cdc2-related kinase 1 0.0108 0.0684 0.2915
Echinococcus granulosus neuroglian 0.0097 0.0569 0.0569
Echinococcus granulosus casein kinase I alpha 0.0058 0.0186 0.0186
Onchocerca volvulus 0.0306 0.264 0.5132
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0239 0.0259
Schistosoma mansoni protein kinase 0.0042 0.0029 0.005
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0119 0.0786 0.3457
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.024 0.1987 0.2411
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.006 0.0209 0.1727
Loa Loa (eye worm) hypothetical protein 0.0127 0.087 0.0944
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0143 0.1027 0.1115
Schistosoma mansoni cell adhesion molecule 0.0101 0.061 0.1055
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0078 0.0223
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.006 0.0209 0.0911
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0019 0.0033
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0119 0.0786 0.3476
Schistosoma mansoni protein kinase 0.0058 0.0186 0.0322
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.006 0.0209 0.0227
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.049 0.2086
Echinococcus granulosus casein kinase I alpha 0.0058 0.0186 0.0186
Schistosoma mansoni adapter molecule crk 0.0056 0.0165 0.0286
Echinococcus granulosus twitchin 0.0115 0.0751 0.0751
Entamoeba histolytica protein kinase, putative 0.0069 0.0297 0.1195
Entamoeba histolytica protein kinase, putative 0.0112 0.0719 0.3073
Echinococcus multilocularis serine:threonine protein kinase 3 0.0253 0.2114 0.2564
Echinococcus multilocularis casein kinase I delta 0.0058 0.0186 0.0226
Schistosoma mansoni tyrosine kinase 0.0625 0.5788 1
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1342 0.1456
Trichomonas vaginalis CAMK family protein kinase 0.0267 0.2253 0.9895
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0058 0.0187 0.0226
Echinococcus granulosus ephrin type A receptor 4 A 0.01 0.0596 0.0596
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.006 0.0209 0.0911
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.1269 0.2192
Plasmodium falciparum protein kinase, putative 0.0051 0.0115 0.0829
Echinococcus granulosus tyrosine protein kinase Fyn 0.015 0.1094 0.1094
Brugia malayi Sex muscle abnormal protein 5 0.0056 0.0165 0.0179
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Entamoeba histolytica protein kinase, putative 0.0094 0.0541 0.2278
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0067 0.0273 0.0273
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0072 0.032 0.1333
Loa Loa (eye worm) hypothetical protein 0.0146 0.105 0.114
Loa Loa (eye worm) AGC/AKT protein kinase 0.027 0.2277 0.2472
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0227 0.1858 0.2016
Brugia malayi STE20-like kinase MST 0.0253 0.2114 0.2295
Echinococcus multilocularis cyclin dependent kinase 1 0.0108 0.0684 0.0829
Schistosoma mansoni protein kinase 0.0051 0.0115 0.0199
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0168 0.1269 0.1269
Giardia lamblia Kinase, NEK 0.0127 0.0863 0.3754
Schistosoma mansoni protein kinase 0.0214 0.1726 0.2983
Plasmodium falciparum calcium-dependent protein kinase 4 0.0042 0.0029 0.0005
Echinococcus granulosus casein kinase i 0.0058 0.0186 0.0186
Entamoeba histolytica casein kinase 1, putative 0.0058 0.0186 0.0704
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0074 0.0344 0.0344
Schistosoma mansoni protein kinase 0.0214 0.1726 0.2983
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0186 0.145 0.1574
Trichomonas vaginalis AGC family protein kinase 0.0136 0.096 0.4168
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0148 0.1071 0.1162
Echinococcus granulosus NDR protein kinase 0.0134 0.0939 0.0939
Giardia lamblia Kinase, CMGC CK2 0.0089 0.049 0.2076
Echinococcus granulosus myotubularin protein 13 0.0042 0.0024 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0158 0.0273
Echinococcus granulosus tyrosine protein kinase ABL1 0.0281 0.2388 0.2388
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0397 0.3538 0.384
Echinococcus granulosus defective proboscis extension response 0.0079 0.0396 0.0396
Echinococcus granulosus RNA directed DNA polymerase 0.0042 0.0023 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0186 0.0322
Echinococcus granulosus aurora kinase A 0.0136 0.096 0.096
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.015 0.1094 0.1094
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0058 0.0186 0.0202
Trichomonas vaginalis STE family protein kinase 0.0074 0.0344 0.1439
Brugia malayi Protein kinase domain containing protein 0.0063 0.0239 0.0259
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0158 0.0171
Echinococcus multilocularis roundabout 2 0.0119 0.0784 0.0951
Echinococcus granulosus casein kinase I delta 0.0058 0.0186 0.0186
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.032 0.1335
Schistosoma mansoni tyrosine kinase 0.024 0.1987 0.3434
Schistosoma mansoni protein kinase 0.0042 0.0029 0.005
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.006 0.0209 0.1727
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0108 0.0684 0.0742
Trichomonas vaginalis AGC family protein kinase 0.006 0.0209 0.0842
Brugia malayi hypothetical protein 0.0063 0.0239 0.0259
Echinococcus multilocularis serine:threonine protein kinase 38 0.0134 0.0939 0.1139
Brugia malayi cell division control protein 2 homolog 0.0108 0.0684 0.0742
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.006 0.0209 0.0209
Brugia malayi Pleckstrin Homology Domain 0.0042 0.0024 0.0026
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0042 0.0029 0.0029
Trichomonas vaginalis AGC family protein kinase 0.027 0.2277 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0158 0.0158
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0042 0.0029 0.0005
Schistosoma mansoni hypothetical protein 0.0064 0.0246 0.0424
Entamoeba histolytica protein kinase, putative 0.0264 0.222 0.9747
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0136 0.0953 0.0953
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0148 0.1076 0.1076
Schistosoma mansoni serine/threonine kinase 0.0134 0.0939 0.1622
Schistosoma mansoni vesicular amine transporter 0.0079 0.0396 0.0684
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.0786 0.337
Brugia malayi Temporarily assigned gene name protein 59 0.0135 0.0949 0.103
Onchocerca volvulus 0.0146 0.105 0.2037
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0107 0.0666 0.0723
Trichomonas vaginalis CK1 family protein kinase 0.0058 0.0186 0.0742
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0158 0.0273
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0028 0.0049
Giardia lamblia Aurora kinase 0.0136 0.096 0.4189
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0056 0.0165 0.0286
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0104 0.0635 0.0689
Leishmania major protein kinase, putative 0.0042 0.0029 0.0002
Onchocerca volvulus 0.0063 0.0239 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0267 0.2253 0.9895
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0042 0.0029 0.0031
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0073 0.033 0.1448
Schistosoma mansoni tyrosine kinase 0.0374 0.331 0.5719
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0078 0.0479
Echinococcus granulosus activin receptor type 0.0051 0.0115 0.0115
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0148 0.1076 1
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0939 0.1622
Echinococcus granulosus tyrosine protein kinase Src42A 0.015 0.1094 0.1094
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0297 0.1231
Echinococcus granulosus Immunoglobulin 0.0079 0.0396 0.0396
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0168 0.1269 0.1539
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0074 0.0344 0.0417
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.1306 0.2257
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0108 0.0684 0.2946
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0428 0.181
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0239 0.0259
Entamoeba histolytica PH domain containing protein kinase, putative 0.0154 0.1133 0.4911
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0397 0.3538 0.3538
Echinococcus granulosus casein kinase ii subunit alpha 0.0089 0.049 0.049
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0041 0.0019 0.0021
Echinococcus multilocularis rho associated protein kinase 0.0325 0.2822 0.3423
Giardia lamblia Kinase, AGC PKA 0.0148 0.1076 0.4708
Schistosoma mansoni tyrosine kinase 0.0374 0.331 0.5719
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.014 0.0995 0.108
Loa Loa (eye worm) hypothetical protein 0.0042 0.0024 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0028 0.0049
Echinococcus granulosus raf serine:threonine protein kinase 0.0068 0.0288 0.0288
Echinococcus granulosus roundabout 2 0.0119 0.0784 0.0784
Onchocerca volvulus Serine\/threonine kinase homolog 0.0267 0.2253 0.438
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.013 0.0894 0.1084
Echinococcus granulosus serine:threonine protein kinase 3 0.0253 0.2114 0.2114
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.032 0.0554
Echinococcus multilocularis tyrosine protein kinase Fgr 0.015 0.1094 0.1327
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0072 0.032 0.0348
Echinococcus granulosus growth factor receptor bound protein 2 0.0056 0.0165 0.0165
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0214 0.1726 0.1726
Trypanosoma brucei polo-like protein kinase 0.0267 0.2253 0.9894
Echinococcus multilocularis tyrosine kinase 0.0063 0.0239 0.029
Echinococcus multilocularis c src tyrosine kinase 0.0088 0.0486 0.059
Brugia malayi casein kinase 1, delta 0.0058 0.0186 0.0202
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0051 0.0115 0.0492
Brugia malayi Furin-like cysteine rich region family protein 0.0625 0.5788 0.6282
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0119 0.0786 0.0853
Leishmania major casein kinase II, putative 0.0089 0.049 0.2076
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.005 0.0106 0.0106
Loa Loa (eye worm) SRC-1 0.015 0.1094 0.1187
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0786 0.3397
Loa Loa (eye worm) hypothetical protein 0.0077 0.0378 0.041
Schistosoma mansoni tyrosine kinase 0.015 0.1094 0.189
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0058 0.0186 0.081
Onchocerca volvulus 0.0063 0.0239 0.0457
Schistosoma mansoni tyrosine kinase 0.0407 0.3631 0.6273
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0264 0.222 0.241
Schistosoma mansoni protein kinase C mu 0.014 0.0995 0.1718
Brugia malayi Protein kinase domain containing protein 0.0194 0.1533 0.1664
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0239 0.0259
Entamoeba histolytica protein kinase domain containing protein 0.0136 0.096 0.4144
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0194 0.1533 0.1533
Echinococcus granulosus protein kinase c iota type 0.0257 0.2153 0.2153
Trypanosoma brucei protein kinase, putative 0.0119 0.0786 0.337
Loa Loa (eye worm) hypothetical protein 0.0116 0.0755 0.0819
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.006 0.0209 0.0254
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0121 0.0121
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1342 0.1628
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0069 0.0297 0.0322
Schistosoma mansoni protein kinase 0.0051 0.0119 0.0206
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0051 0.0115 0.0492
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0151 0.1102 0.4879
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0058 0.0187 0.0187
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.049 0.2086
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0266 0.1058
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0069 0.0297 0.0297
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0079 0.0396 0.0684
Echinococcus multilocularis cyclin dependent kinase 0.0108 0.0684 0.0829
Schistosoma mansoni tyrosine kinase 0.0203 0.1621 0.2801
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0158 0.0192
Trypanosoma brucei Casein kinase II 0.0089 0.049 0.2054
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0684 0.2944
Schistosoma mansoni tyrosine kinase 0.025 0.2082 0.3597
Brugia malayi Protein kinase domain containing protein 0.0104 0.0635 0.0689
Echinococcus multilocularis tyrosine protein kinase shark 0.0063 0.0239 0.029
Brugia malayi SH2 domain containing protein 0.0063 0.0239 0.0259
Loa Loa (eye worm) TK/EPH protein kinase 0.0118 0.0778 0.0845
Brugia malayi SH2 domain containing protein 0.0063 0.0239 0.0259
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0069 0.0297 0.036
Onchocerca volvulus 0.0121 0.0813 0.1574
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.006 0.0209 0.0254
Leishmania major protein kinase A catalytic subunit 0.006 0.0209 0.0813
Loa Loa (eye worm) AGC/NDR protein kinase 0.0134 0.0939 0.1019
Loa Loa (eye worm) hypothetical protein 0.008 0.0398 0.0432
Trichomonas vaginalis AGC family protein kinase 0.027 0.2277 1
Trypanosoma brucei casein kinase I, isoform 2 0.0058 0.0186 0.0704
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Brugia malayi serine/threonine protein kinase 6 0.0136 0.096 0.1042
Brugia malayi Protein kinase domain containing protein 0.0134 0.0939 0.1019
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0063 0.0239 0.0937
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0019 0.0033
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0112 0.0719 0.3179
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0049 0.01 0.032
Echinococcus multilocularis death associated protein kinase 1 0.0873 0.8244 1
Trypanosoma cruzi p21-activated kinase 3, putative 0.0041 0.0019 0.0065
Onchocerca volvulus 0.0063 0.0239 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Loa Loa (eye worm) hypothetical protein 0.0094 0.0537 0.0583
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0042 0.0028 0.0031
Entamoeba histolytica cell division protein kinase 2, putative 0.0108 0.0684 0.2915
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Brugia malayi Fibronectin type III domain containing protein 0.0082 0.0421 0.0457
Echinococcus multilocularis RNA directed DNA polymerase 0.0042 0.0023 0.0028
Giardia lamblia Kinase, STE STE20 0.0073 0.033 0.1356
Echinococcus granulosus rho-associated protein kinase 1 0.0325 0.2822 0.2822
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0151 0.1102 0.4824
Brugia malayi serine/threonine-protein kinase plk-2 0.0267 0.2253 0.2446
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0134 0.0939 0.1139
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0073 0.033 0.1342
Plasmodium falciparum calcium-dependent protein kinase 1 0.0042 0.0029 0.0005
Brugia malayi p70 ribosomal S6 kinase beta 0.0264 0.222 0.241
Echinococcus multilocularis rac serine:threonine kinase 0.0154 0.1133 0.1374
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0067 0.0273 0.0471
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0112 0.0719 0.3106
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0151 0.1102 0.1196
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0186 0.145 0.145
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1342 0.2318
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0134 0.0939 0.1019
Echinococcus multilocularis tyrosine protein kinase Fyn 0.015 0.1094 0.1327
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0029 0.005
Brugia malayi Stress-activated protein kinase jnk-1 0.0261 0.2191 0.2378
Loa Loa (eye worm) hypothetical protein 0.028 0.2377 0.258
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0061 0.0218 0.0237
Trypanosoma cruzi casein kinase II, putative 0.0089 0.049 0.216
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0134 0.0939 0.0939
Trichomonas vaginalis AGC family protein kinase 0.027 0.2277 1
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0028 0.0041
Entamoeba histolytica casein kinase, putative 0.0058 0.0186 0.0704
Leishmania major protein kinase, putative 0.0136 0.096 0.4189
Schistosoma mansoni tyrosine kinase 0.0065 0.0258 0.0446
Entamoeba histolytica protein kinase, putative 0.0134 0.0939 0.4049
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.015 0.1094 0.1327
Echinococcus multilocularis protein kinase c epsilon type 0.0171 0.1306 0.1585
Entamoeba histolytica hypothetical protein 0.0112 0.0719 0.3073
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0072 0.032 0.1405
Schistosoma mansoni tyrosine kinase 0.0454 0.4103 0.7089
Echinococcus multilocularis casein kinase i 0.0058 0.0186 0.0226
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0261 0.2191 0.2378
Loa Loa (eye worm) TK protein kinase 0.0258 0.2161 0.2345
Trichomonas vaginalis AGC family protein kinase 0.0134 0.0939 0.4073
Entamoeba histolytica protein kinase, putative 0.0057 0.0176 0.0658
Loa Loa (eye worm) hypothetical protein 0.0067 0.0275 0.0299
Echinococcus granulosus serine threonine protein kinase nrc 0.0148 0.1076 0.1076
Brugia malayi Tyrosine-protein kinase abl-1 0.0172 0.1308 0.142
Loa Loa (eye worm) hypothetical protein 0.0056 0.0165 0.0179
Toxoplasma gondii aurora kinase 0.0136 0.096 0.4252
Trichomonas vaginalis CAMK family protein kinase 0.0267 0.2253 0.9895
Entamoeba histolytica protein kinase, putative 0.0074 0.0344 0.1404
Loa Loa (eye worm) TK/ROR protein kinase 0.005 0.0106 0.0115
Brugia malayi Protein kinase domain containing protein 0.0063 0.0239 0.0259
Brugia malayi casein kinase I 0.0058 0.0186 0.0202
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0407 0.3631 0.3631
Loa Loa (eye worm) TK/FER protein kinase 0.0063 0.0239 0.0259
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0073 0.033 0.1342
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0072 0.032 0.1313
Entamoeba histolytica protein kinase, putative 0.027 0.2277 1
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0194 0.1533 0.1664
Echinococcus granulosus protein kinase c epsilon type 0.0171 0.1306 0.1306
Trypanosoma brucei rac serine-threonine kinase, putative 0.027 0.2277 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.006 0.0209 0.0254
Entamoeba histolytica protein kinase, putative 0.0051 0.0119 0.0405
Echinococcus granulosus NCK adaptor protein 0.0056 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0094 0.0537 0.0583
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0939 0.1622
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.1027 0.1774
Trichomonas vaginalis AGC family protein kinase 0.027 0.2277 1
Brugia malayi Protein kinase domain containing protein 0.0063 0.0239 0.0259
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0112 0.0719 0.3073
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.032 0.1335
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0041 0.0019 0.0021
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0186 0.145 0.1759
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0186 0.145 0.2816
Entamoeba histolytica protein kinase, putative 0.0057 0.0176 0.0658
Echinococcus granulosus c src tyrosine kinase 0.0088 0.0486 0.0486
Toxoplasma gondii AGC kinase 0.006 0.0209 0.0825
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0104 0.064 0.0695

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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