Detailed information for compound 1967181

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 404.465 | Formula: C22H24N6O2
  • H donors: 0 H acceptors: 5 LogP: 3.03 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(n1)C(=O)N1C2CCC1C(C2)COc1cccnc1C)n1nccn1
  • InChi: 1S/C22H24N6O2/c1-14-5-7-19(28-24-10-11-25-28)21(26-14)22(29)27-17-6-8-18(27)16(12-17)13-30-20-4-3-9-23-15(20)2/h3-5,7,9-11,16-18H,6,8,12-13H2,1-2H3
  • InChiKey: XIZVZLSOWLSJJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Orexin receptor 1 Starlite/ChEMBL No references
Homo sapiens hypocretin (orexin) receptor 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus multilocularis G protein coupled receptor 139 Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus multilocularis neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus granulosus neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Get druggable targets OG5_127863 All targets in OG5_127863
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Orexin receptor 1   416 aa 405 aa 19.0 %
Onchocerca volvulus Orexin receptor 1   416 aa 397 aa 22.9 %
Onchocerca volvulus Orexin receptor 1   416 aa 439 aa 23.7 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Orexin receptor 1   416 aa 376 aa 22.1 %
Echinococcus multilocularis allatostatin A receptor Orexin receptor 1   416 aa 341 aa 24.9 %
Schistosoma mansoni biogenic amine (5HT) receptor Orexin receptor 1   416 aa 406 aa 23.2 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Orexin receptor 1   416 aa 360 aa 27.2 %
Echinococcus multilocularis neuropeptides capa receptor Orexin receptor 1   416 aa 438 aa 22.4 %
Echinococcus granulosus orexin receptor type 2 Orexin receptor 1   416 aa 377 aa 24.7 %
Echinococcus granulosus allatostatin A receptor Orexin receptor 1   416 aa 345 aa 24.9 %
Loa Loa (eye worm) hypothetical protein Orexin receptor 1   416 aa 391 aa 24.3 %
Schistosoma mansoni dro/myosuppressin receptor Orexin receptor 1   416 aa 334 aa 21.9 %
Onchocerca volvulus Orexin receptor 1   416 aa 364 aa 25.3 %
Echinococcus multilocularis rhodopsin orphan GPCR Orexin receptor 1   416 aa 354 aa 22.0 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Orexin receptor 1   416 aa 405 aa 20.2 %
Echinococcus granulosus thyrotropin releasing hormone receptor Orexin receptor 1   416 aa 344 aa 28.2 %
Echinococcus multilocularis g protein coupled receptor Orexin receptor 1   416 aa 413 aa 23.2 %
Schistosoma japonicum FMRFamide receptor, putative Orexin receptor 1   416 aa 387 aa 20.2 %
Onchocerca volvulus Phospholipase d-related homolog Orexin receptor 1   416 aa 344 aa 22.4 %
Echinococcus granulosus rhodopsin orphan GPCR Orexin receptor 1   416 aa 369 aa 22.0 %
Echinococcus multilocularis sex peptide receptor Orexin receptor 1   416 aa 416 aa 22.8 %
Echinococcus granulosus sex peptide receptor Orexin receptor 1   416 aa 413 aa 23.2 %
Echinococcus multilocularis orexin receptor type 2 Orexin receptor 1   416 aa 378 aa 23.8 %
Echinococcus granulosus g protein coupled receptor Orexin receptor 1   416 aa 413 aa 23.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Peroxidasin 0.0075 0.2759 0.5722
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0075 0.0156
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0616 0.2301
Schistosoma mansoni hypothetical protein 0.0012 0.0233 0.0233
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0555 0.951
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0919 0.1906
Brugia malayi Cation transporter family protein 0.003 0.0919 0.1906
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0075 0.0156
Brugia malayi Calcium binding EGF domain containing protein 0.0012 0.0233 0.0484
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0616 0.2301
Echinococcus multilocularis calpain A 0.0061 0.2176 0.2117
Echinococcus granulosus RUN 0.002 0.0555 0.0483
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0012 0.0233 0.0333
Schistosoma mansoni rab6-interacting 0.002 0.0555 0.0555
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0061 0.2176 0.2176
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Echinococcus granulosus neurogenic locus notch protein 0.0012 0.0233 0.0159
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0919 0.1906
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0082 0.3024 0.627
Schistosoma mansoni notch 0.0012 0.0233 0.0233
Brugia malayi Doublecortin family protein 0.002 0.0555 0.1151
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0616 0.8724
Brugia malayi Animal haem peroxidase family protein 0.0075 0.2759 0.5722
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0919 0.1906
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Echinococcus multilocularis RUN 0.002 0.0555 0.0483
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0008 0.0075 0.0156
Schistosoma mansoni steroid hormone receptor ad4bp 0.0008 0.0075 0.0075
Echinococcus multilocularis neuropeptide receptor 0.0128 0.488 0.4841
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0616 0.0616
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0919 0.085
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.0245 0.223
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Toxoplasma gondii EGF family domain-containing protein 0.0012 0.0233 0.212
Loa Loa (eye worm) hypothetical protein 0.0026 0.0795 0.165
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0026 0.0776 0.0706
Onchocerca volvulus 0.003 0.0919 0.1777
Schistosoma mansoni lipoxygenase 0.0085 0.3164 0.3164
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0245 0.1001
Schistosoma mansoni hypothetical protein 0.0012 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.002 0.0555 0.1151
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Brugia malayi hypothetical protein 0.0075 0.2759 0.5722
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.2678 0.2678
Echinococcus granulosus expressed conserved protein 0.0058 0.2056 0.1996
Schistosoma mansoni laminin gamma-3 chain 0.0012 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0012 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Schistosoma mansoni acetylcholine receptor subunit beta 0.0014 0.0281 0.0281
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0016 0.0373 0.0373
Entamoeba histolytica hypothetical protein 0.0023 0.0638 0.2892
Schistosoma mansoni hypothetical protein 0.0012 0.0233 0.0233
Schistosoma mansoni patched 1 0.0026 0.0795 0.0795
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0919 0.0919
Schistosoma mansoni peroxidasin 0.0075 0.2759 0.2759
Brugia malayi Cation transporter family protein 0.003 0.0919 0.1906
Loa Loa (eye worm) acetylcholine receptor protein 0.0014 0.0281 0.0583
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.003 0.0919 0.1906
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.003 0.0919 0.1906
Onchocerca volvulus Putative nachr subunit 0.003 0.0919 0.1777
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0245 0.0171
Trypanosoma brucei cysteine peptidase C (CPC) 0.0024 0.0706 0.288
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Schistosoma mansoni neurotransmitter gated ion channel 0.0014 0.0281 0.0281
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.003 0.0919 0.085
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Echinococcus granulosus Protein patched homolog 1 0.0026 0.0795 0.0726
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Brugia malayi EGF-like domain containing protein 0.0012 0.0233 0.0484
Loa Loa (eye worm) hypothetical protein 0.0008 0.0075 0.0156
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.003 0.0919 0.1906
Schistosoma mansoni cell polarity protein 0.0012 0.0233 0.0233
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0616 0.8724
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.003 0.0919 0.085
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0075 0.0156
Brugia malayi hypothetical protein 0.002 0.0555 0.1151
Schistosoma mansoni cpg binding protein 0.0018 0.0456 0.0456
Onchocerca volvulus 0.0075 0.2759 0.5654
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0919 0.085
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Echinococcus multilocularis cathepsin b 0.0073 0.2678 0.2622
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0013 0.0245 0.0245
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0245 0.0171
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.003 0.0919 0.085
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Loa Loa (eye worm) doublecortin family protein 0.002 0.0555 0.1151
Loa Loa (eye worm) calpain family protein 1 0.0043 0.1454 0.3016
Brugia malayi hypothetical protein 0.0014 0.0281 0.0583
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0009 0.0116 0.0041
Loa Loa (eye worm) hypothetical protein 0.0016 0.0373 0.0773
Echinococcus granulosus neuropeptide receptor 0.0128 0.488 0.4841
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0014 0.0281 0.0583
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0014 0.0281 0.0583
Echinococcus granulosus calpain 7 C02 family 0.0022 0.0616 0.0545
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0009 0.0116 0.0041
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0555 0.0483
Brugia malayi Steroid receptor seven-up type 2 0.0008 0.0075 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0075 0.0156
Echinococcus multilocularis protein patched 0.0026 0.0795 0.0726
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0245 0.3475
Echinococcus granulosus calpain A 0.0061 0.2176 0.2117
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0919 0.085
Echinococcus multilocularis hypothetical protein 0.0022 0.0616 0.0545
Trypanosoma cruzi kinesin, putative 0.0015 0.0351 0.1312
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.003 0.0919 0.1906
Echinococcus granulosus protein jagged 1 0.0012 0.0233 0.0159
Brugia malayi hypothetical protein 0.0014 0.0281 0.0583
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Schistosoma mansoni polycystin 1-related 0.002 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Onchocerca volvulus Peroxidasin homolog 0.0075 0.2759 0.5654
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0014 0.0281 0.0207
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0013 0.0245 0.0171
Loa Loa (eye worm) blistered cuticle protein 3 0.0075 0.2759 0.5722
Schistosoma mansoni nAChR subunit 0.003 0.0919 0.0919
Echinococcus granulosus Niemann Pick C1 protein 0.0062 0.2206 0.2147
Echinococcus multilocularis Niemann Pick C1 protein 0.0088 0.3266 0.3215
Schistosoma mansoni neurotransmitter gated ion channel 0.0016 0.0373 0.0373
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.003 0.0919 0.1906
Schistosoma mansoni septate junction protein 0.0012 0.0233 0.0233
Loa Loa (eye worm) Notch2 0.0012 0.0233 0.0484
Echinococcus multilocularis slit 2 protein 0.0012 0.0233 0.0159
Schistosoma mansoni acetylcholine receptor-related 0.0014 0.0281 0.0281
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0008 0.0075 0.0075
Echinococcus multilocularis protein dispatched 1 0.003 0.0945 0.0876
Brugia malayi Calcium binding EGF domain containing protein 0.0012 0.0233 0.0484
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0919 0.0919
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0616 0.2513
Echinococcus multilocularis GPCR, family 2 0.0026 0.0776 0.0706
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0555 0.0483
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0014 0.0281 0.0583
Brugia malayi Niemann-Pick C1 protein precursor 0.0062 0.2206 0.4574
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0008 0.0075 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0008 0.0075 0.0156
Schistosoma mansoni notch 0.0012 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.003 0.0919 0.085
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Onchocerca volvulus 0.0012 0.0233 0.0333
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0245 0.0917
Echinococcus multilocularis calpain 0.0022 0.0616 0.0545
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0919 0.1906
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Schistosoma mansoni nAChR subunit 0.003 0.0919 0.0919
Echinococcus granulosus glycine receptor subunit beta 0.003 0.0919 0.085
Loa Loa (eye worm) hypothetical protein 0.0008 0.0075 0.0156
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0013 0.0245 0.4205
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0022 0.0616 0.2513
Echinococcus multilocularis fat cadherin tumor suppressor 0.0012 0.0233 0.0159
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Onchocerca volvulus 0.0014 0.0281 0.0434
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0063 0.2244 0.2244
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0061 0.2176 0.2117
Onchocerca volvulus Slit protein homolog 0.0012 0.0233 0.0333
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Schistosoma mansoni notch 0.0012 0.0233 0.0233
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.003 0.0919 0.085
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0584 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0008 0.0075 0.0156
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0281 0.0583
Loa Loa (eye worm) ACC-1 protein 0.003 0.0919 0.1906
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Brugia malayi EGF-like domain containing protein 0.0012 0.0233 0.0484
Loa Loa (eye worm) hypothetical protein 0.0073 0.2678 0.5553
Brugia malayi Blistered cuticle protein 3 0.0075 0.2759 0.5722
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Brugia malayi EGF-like domain containing protein 0.0012 0.0233 0.0484
Loa Loa (eye worm) hypothetical protein 0.0016 0.0373 0.0773
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Schistosoma mansoni hypothetical protein 0.0012 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0058 0.2071 0.4294
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.003 0.0919 0.1906
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0008 0.0075 0.0156
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Echinococcus multilocularis peroxidasin 0.0075 0.2759 0.2704
Loa Loa (eye worm) calpain 0.0022 0.0616 0.1278
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0026 0.0776 0.0706
Schistosoma mansoni hypothetical protein 0.0068 0.2452 0.2452
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0584 0.218
Schistosoma mansoni nAChR subunit 0.003 0.0919 0.0919
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0075 0.0075
Echinococcus multilocularis isocitrate dehydrogenase 0.0013 0.0245 0.0171
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Schistosoma mansoni hypothetical protein 0.0026 0.0776 0.0776
Schistosoma mansoni transcription factor LCR-F1 0.0023 0.0638 0.0638
Echinococcus multilocularis calpain family protein 1, d 0.0043 0.1454 0.139
Brugia malayi calpain 5 0.0015 0.0351 0.0728
Echinococcus multilocularis Niemann Pick C1 protein 0.0062 0.2206 0.2147
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0024 0.0706 1
Brugia malayi steroid hormone receptor 0.0008 0.0075 0.0156
Schistosoma mansoni hypothetical protein 0.0023 0.0638 0.0638
Echinococcus multilocularis fibropellin Ia 0.0012 0.0233 0.0159
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0555 0.0483
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0919 0.1906
Echinococcus multilocularis protein jagged 1 0.0012 0.0233 0.0159
Echinococcus granulosus notch 0.0012 0.0233 0.0159
Echinococcus multilocularis neurogenic locus notch protein 4 0.0012 0.0233 0.0159
Onchocerca volvulus 0.0036 0.119 0.2347
Loa Loa (eye worm) animal heme peroxidase 0.0075 0.2759 0.5722
Onchocerca volvulus 0.0018 0.0456 0.0802
Loa Loa (eye worm) latrophilin receptor protein 2 0.0026 0.0776 0.1608
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0075 0.0156
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0008 0.0075 0.0075
Onchocerca volvulus 0.0016 0.0373 0.0627
Brugia malayi latrophilin 2 splice variant baaae 0.0056 0.1983 0.4112
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0008 0.0075 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0008 0.0075 0.0156
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0919 0.1906
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0062 0.2206 1
Echinococcus multilocularis cathepsin b 0.0073 0.2678 0.2622
Loa Loa (eye worm) hypothetical protein 0.0026 0.0776 0.1608
Loa Loa (eye worm) transcription factor SMAD2 0.0085 0.3155 0.6543
Echinococcus multilocularis protein jagged 2 0.0012 0.0233 0.0159
Brugia malayi excitatory GABA receptor EXP-1A 0.003 0.0919 0.1906
Schistosoma mansoni hypothetical protein 0.0025 0.0757 0.0757
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.003 0.0919 0.0919
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0555 0.0483
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0008 0.0075 0.0156
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.464 0.4599
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0023 0.0638 0.0567
Loa Loa (eye worm) hypothetical protein 0.0008 0.0075 0.0156
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0014 0.0281 0.0207
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0008 0.0075 0.0075
Loa Loa (eye worm) animal heme peroxidase 0.0075 0.2759 0.5722
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0616 0.2513
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0555 0.0483
Loa Loa (eye worm) hypothetical protein 0.0043 0.1454 0.3016
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0919 0.085
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Schistosoma mansoni hypothetical protein 0.0012 0.0233 0.0233
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0919 0.085
Entamoeba histolytica hypothetical protein 0.0023 0.0638 0.2892
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Loa Loa (eye worm) hypothetical protein 0.0082 0.3024 0.627
Giardia lamblia Cathepsin B precursor 0.0024 0.0706 1
Onchocerca volvulus 0.0012 0.0233 0.0333
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0026 0.0795 0.165
Loa Loa (eye worm) hypothetical protein 0.0036 0.119 0.2467
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0061 0.2176 0.2176
Onchocerca volvulus 0.0075 0.2759 0.5654
Echinococcus granulosus neurogenic locus notch protein 4 0.0012 0.0233 0.0159
Loa Loa (eye worm) animal heme peroxidase 0.0075 0.2759 0.5722
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Brugia malayi calpain family protein 1 0.0058 0.2071 0.4294
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0616 0.2301
Brugia malayi GCC2 and GCC3 family protein 0.0012 0.0233 0.0484
Echinococcus multilocularis protein jagged 1 0.0012 0.0233 0.0159
Onchocerca volvulus 0.0127 0.4822 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0013 0.0245 0.0171
Brugia malayi Animal haem peroxidase family protein 0.0075 0.2759 0.5722
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0584 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0026 0.0795 0.0726
Brugia malayi MH2 domain containing protein 0.0085 0.3155 0.6543
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Echinococcus granulosus peroxidasin 0.0075 0.2759 0.2704
Onchocerca volvulus 0.003 0.0919 0.1777
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0014 0.0281 0.0207
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0919 0.1906
Trypanosoma brucei RNA helicase, putative 0.0068 0.2452 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0014 0.0281 0.0583
Echinococcus multilocularis neurogenic locus protein delta 0.0012 0.0233 0.0159
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Onchocerca volvulus 0.003 0.0919 0.1777
Loa Loa (eye worm) hypothetical protein 0.002 0.0555 0.1151
Toxoplasma gondii cathepsin B 0.0024 0.0706 0.6417
Schistosoma mansoni hypothetical protein 0.0026 0.0776 0.0776
Echinococcus granulosus cathepsin b 0.0073 0.2678 0.2622
Echinococcus multilocularis cpg binding protein 0.0019 0.0497 0.0425
Echinococcus granulosus sterol regulatory element binding protein 0.0026 0.0795 0.0726
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0061 0.2176 0.2117
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.464 0.4599
Brugia malayi calpain family protein 1 0.0058 0.2071 0.4294
Schistosoma mansoni hypothetical protein 0.0009 0.0116 0.0116
Onchocerca volvulus 0.0075 0.2759 0.5654
Entamoeba histolytica calpain large subunit domain III containing protein 0.0015 0.0351 0.1592
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.003 0.0919 0.1906
Brugia malayi hypothetical protein 0.0021 0.0584 0.1211
Brugia malayi EGF-like domain containing protein 0.0012 0.0233 0.0484
Echinococcus multilocularis neurogenic locus notch protein 0.0012 0.0233 0.0159
Schistosoma mansoni notch 0.0012 0.0233 0.0233
Schistosoma mansoni nAChR subunit 0.003 0.0919 0.0919
Echinococcus multilocularis nAChR subunit 0.003 0.0919 0.085
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.003 0.0919 0.1906
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.003 0.0919 0.1906
Brugia malayi notch-like transmembrane receptor 0.0012 0.0233 0.0484
Loa Loa (eye worm) CXXC zinc finger family protein 0.0018 0.0456 0.0945
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0616 0.2513
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.2071 0.2071
Brugia malayi EGF-like domain containing protein 0.0012 0.0233 0.0484
Onchocerca volvulus Peroxidasin homolog 0.0075 0.2759 0.5654
Schistosoma mansoni hypothetical protein 0.0012 0.0233 0.0233
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0075 0.0156
Toxoplasma gondii histone lysine methyltransferase SET1 0.0034 0.1101 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Schistosoma mansoni hypothetical protein 0.0056 0.1983 0.1983
Onchocerca volvulus Peroxidase homolog 0.0075 0.2759 0.5654
Loa Loa (eye worm) animal heme peroxidase 0.0075 0.2759 0.5722
Schistosoma mansoni rab6-interacting 0.002 0.0555 0.0555
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.0245 0.223
Onchocerca volvulus Putative cubilin 0.0012 0.0233 0.0333
Schistosoma mansoni neuropeptide receptor 0.0128 0.488 0.488
Loa Loa (eye worm) hypothetical protein 0.0008 0.0075 0.0156
Schistosoma mansoni hypothetical protein 0.0025 0.0757 0.0757
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0616 0.2301
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Schistosoma mansoni nAChR subunit 0.003 0.0919 0.0919
Entamoeba histolytica protein kinase, putative 0.0015 0.0351 0.1592
Echinococcus multilocularis neurogenic locus protein delta 0.0012 0.0233 0.0159
Brugia malayi photoreceptor-specific nuclear receptor 0.0008 0.0075 0.0156
Trypanosoma brucei kinesin, putative 0.0015 0.0351 0.1433
Loa Loa (eye worm) cathepsin B 0.0024 0.0706 0.1465
Brugia malayi Cation transporter family protein 0.003 0.0919 0.1906
Loa Loa (eye worm) hypothetical protein 0.0008 0.0075 0.0156
Brugia malayi Cadherin domain containing protein 0.0012 0.0233 0.0484
Brugia malayi CXXC zinc finger family protein 0.0018 0.0456 0.0945
Schistosoma mansoni calpain (C02 family) 0.0022 0.0616 0.0616
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.003 0.0919 0.085
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.003 0.0919 0.085
Brugia malayi ecdysteroid receptor 0.0008 0.0075 0.0156
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Schistosoma mansoni hypothetical protein 0.002 0.0555 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0075 0.0156
Loa Loa (eye worm) MH2 domain-containing protein 0.0085 0.3155 0.6543
Loa Loa (eye worm) hypothetical protein 0.0016 0.0373 0.0773
Echinococcus granulosus protein jagged 2 0.0012 0.0233 0.0159
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Schistosoma mansoni slit 0.0012 0.0233 0.0233
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0555 0.0483
Echinococcus multilocularis neurogenic locus notch protein 0.0012 0.0233 0.0159
Loa Loa (eye worm) hypothetical protein 0.0008 0.0075 0.0156
Schistosoma mansoni nAChR subunit 0.0014 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0056 0.1983 0.4112
Echinococcus granulosus slit 2 protein 0.0012 0.0233 0.0159
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0616 0.2513
Loa Loa (eye worm) calpain 5 0.0015 0.0351 0.0728
Onchocerca volvulus 0.0014 0.0281 0.0434
Onchocerca volvulus 0.0016 0.0373 0.0627
Entamoeba histolytica hypothetical protein 0.0023 0.0638 0.2892
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Brugia malayi Delta serrate ligand family protein 0.0012 0.0233 0.0484
Onchocerca volvulus 0.002 0.0555 0.1011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Echinococcus granulosus protein jagged 2 0.0012 0.0233 0.0159
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0281 0.0583
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0616 0.2301
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0245 0.0171
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Schistosoma mansoni calpain C (C02 family) 0.0022 0.0616 0.0616
Brugia malayi hypothetical protein 0.002 0.0555 0.1151
Brugia malayi calpain 7 0.0022 0.0616 0.1278
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Schistosoma mansoni Mername-AA248 (C02 family) 0.0022 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Leishmania major hypothetical protein, conserved 0.0021 0.0584 0.8266
Schistosoma mansoni peroxidasin 0.0075 0.2759 0.2759
Trypanosoma brucei antigen, putative 0.0022 0.0616 0.2513
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0008 0.0075 0.0156
Echinococcus multilocularis glycine receptor subunit beta 0.003 0.0919 0.085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0373 0.0773
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0008 0.0075 0.0156
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.003 0.0919 0.1906
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Loa Loa (eye worm) hypothetical protein 0.0016 0.0373 0.0773
Brugia malayi Isocitrate dehydrogenase 0.0013 0.0245 0.0509
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0016 0.0373 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0008 0.0075 0.0156
Brugia malayi Animal haem peroxidase family protein 0.0075 0.2759 0.5722
Echinococcus granulosus delta-like protein 1 0.0012 0.0233 0.0159
Schistosoma mansoni hypothetical protein 0.0012 0.0233 0.0233
Onchocerca volvulus Neurogenic locus notch homolog 0.0012 0.0233 0.0333
Schistosoma mansoni RAR-like nuclear receptor 0.0008 0.0075 0.0075
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.2678 0.2678
Loa Loa (eye worm) hypothetical protein 0.0008 0.0075 0.0156
Onchocerca volvulus 0.0014 0.0281 0.0434
Brugia malayi isocitrate dehydrogenase 0.0013 0.0245 0.0509
Echinococcus multilocularis nAChR subunit 0.0016 0.0373 0.03
Brugia malayi hypothetical protein 0.0014 0.0281 0.0583
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.003 0.0919 0.085
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0014 0.0281 0.0583
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0008 0.0075 0.0156
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0026 0.0776 0.0706
Schistosoma mansoni cpg binding protein 0.0019 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Echinococcus granulosus nAChR subunit 0.0016 0.0373 0.03
Onchocerca volvulus Dual oxidase homolog 0.0075 0.2759 0.5654
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.003 0.0919 0.085
Echinococcus multilocularis expressed conserved protein 0.0058 0.2056 0.1996
Schistosoma mansoni lipoxygenase 0.0122 0.464 0.464
Echinococcus granulosus neurogenic locus notch protein 0.0012 0.0233 0.0159
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0919 0.0919
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0616 0.2513
Brugia malayi hypothetical protein 0.0023 0.0638 0.1323
Echinococcus multilocularis neural cadherin 0.0012 0.0233 0.0159
Schistosoma mansoni hypothetical protein 0.0025 0.0757 0.0757
Onchocerca volvulus 0.003 0.0919 0.1777
Schistosoma mansoni nAChR subunit 0.003 0.0919 0.0919
Schistosoma mansoni loxhd1 0.002 0.0555 0.0555
Onchocerca volvulus 0.0012 0.0233 0.0333
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0012 0.0233 0.0484
Onchocerca volvulus 0.0012 0.0233 0.0333
Echinococcus granulosus calpain 0.0022 0.0616 0.0545
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0919 0.1906
Loa Loa (eye worm) isocitrate dehydrogenase 0.0013 0.0245 0.0509
Brugia malayi hypothetical protein 0.0014 0.0281 0.0583
Schistosoma mansoni notch 0.0012 0.0233 0.0233
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0919 0.085
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0008 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Loa Loa (eye worm) steroid hormone receptor 0.0008 0.0075 0.0156
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Echinococcus granulosus cpg binding protein 0.0019 0.0497 0.0425
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Loa Loa (eye worm) hypothetical protein 0.0016 0.0373 0.0773
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Brugia malayi CHE-14 protein 0.0026 0.0795 0.165
Brugia malayi Calcitonin receptor-like protein seb-1 0.0082 0.3024 0.627
Schistosoma mansoni nAChR subunit 0.003 0.0919 0.0919
Echinococcus granulosus neural cadherin 0.0012 0.0233 0.0159
Onchocerca volvulus 0.003 0.0919 0.1777
Entamoeba histolytica hypothetical protein 0.0023 0.0638 0.2892
Onchocerca volvulus 0.003 0.0919 0.1777
Onchocerca volvulus 0.0012 0.0233 0.0333
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Echinococcus granulosus nAChR subunit 0.003 0.0919 0.085
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0022 0.0616 0.2301
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0016 0.0373 0.0773
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0584 0.218
Echinococcus multilocularis dnaJ subfamily B 0.0256 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0373 0.0773
Schistosoma mansoni hypothetical protein 0.0026 0.0776 0.0776
Schistosoma mansoni hypothetical protein 0.0256 1 1
Brugia malayi Muscle positioning protein 4 0.0012 0.0233 0.0484
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.003 0.0919 0.1906
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0075 0.0075
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.0706 0.0706
Echinococcus granulosus GPCR family 2 0.0026 0.0776 0.0706
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0013 0.0245 0.0917
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.003 0.0919 0.085
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.003 0.0919 0.085
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0616 0.2301
Schistosoma mansoni neurotransmitter gated ion channel 0.0014 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Schistosoma mansoni notch 0.0012 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0032 0.1034 0.2144
Brugia malayi EGF-like domain containing protein 0.0012 0.0233 0.0484
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Echinococcus granulosus Niemann Pick C1 protein 0.0088 0.3266 0.3215
Loa Loa (eye worm) calpain family protein 1 0.0058 0.2071 0.4294
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0616 0.2301
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0026 0.0776 0.1608
Schistosoma mansoni hypothetical protein 0.0026 0.0776 0.0776
Loa Loa (eye worm) ACC-1 protein 0.003 0.0919 0.1906
Loa Loa (eye worm) hypothetical protein 0.0075 0.2759 0.5722
Echinococcus granulosus calpain 5 0.0022 0.0616 0.0545
Loa Loa (eye worm) hypothetical protein 0.0052 0.1806 0.3745
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0073 0.2678 1
Onchocerca volvulus Chorion peroxidase homolog 0.0075 0.2759 0.5654
Brugia malayi cathepsin B-like cysteine proteinase 0.0073 0.2678 0.5553
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.1264 0.1264
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.003 0.0919 0.0919
Brugia malayi nuclear receptor NHR-88 0.0008 0.0075 0.0156
Loa Loa (eye worm) notch protein 0.0012 0.0233 0.0484
Entamoeba histolytica hypothetical protein 0.0016 0.0373 0.1691
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Echinococcus granulosus cathepsin b 0.0073 0.2678 0.2622
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0555 0.8355
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0795 1
Trypanosoma cruzi kinesin, putative 0.0015 0.0351 0.1312
Echinococcus multilocularis calpain 7 (C02 family) 0.0022 0.0616 0.0545
Schistosoma mansoni retinoic acid receptor RXR 0.0008 0.0075 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0008 0.0075 0.0156
Echinococcus granulosus calpain A 0.0022 0.0616 0.0545
Echinococcus multilocularis G protein coupled receptor 139 0.0128 0.488 0.4841
Loa Loa (eye worm) hypothetical protein 0.0021 0.0584 0.1211
Leishmania major kinesin, putative 0.0015 0.0351 0.4974
Schistosoma mansoni cpg binding protein 0.0019 0.0497 0.0497
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0281 0.0583
Loa Loa (eye worm) hypothetical protein 0.0062 0.2206 0.4574
Echinococcus granulosus neurogenic locus protein delta 0.0012 0.0233 0.0159
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0016 0.0373 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0008 0.0075 0.0156
Brugia malayi Animal haem peroxidase family protein 0.0075 0.2759 0.5722
Loa Loa (eye worm) LGC-31 protein 0.003 0.0919 0.1906
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0013 0.0245 0.1001
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0075 0.0075
Onchocerca volvulus Peroxidase homolog 0.0075 0.2759 0.5654
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0014 0.0281 0.0207
Echinococcus multilocularis notch 0.0012 0.0233 0.0159
Schistosoma mansoni nAChR subunit 0.0014 0.0281 0.0281
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0023 0.0638 0.0567
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0616 0.2301
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.0706 0.8878
Brugia malayi hypothetical protein 0.0014 0.0281 0.0583
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.2678 0.2678
Brugia malayi Latrophilin receptor protein 2 0.0026 0.0776 0.1608
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.003 0.0919 0.085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0373 0.0773
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.003 0.0919 0.1906
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0016 0.0373 0.0773
Giardia lamblia Cathepsin B precursor 0.0024 0.0706 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Onchocerca volvulus 0.002 0.0555 0.1011
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0016 0.0373 0.0773
Loa Loa (eye worm) hypothetical protein 0.0008 0.0075 0.0156
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0013 0.0245 0.5
Loa Loa (eye worm) hypothetical protein 0.0127 0.4822 1
Schistosoma mansoni hypothetical protein 0.0025 0.0757 0.0757
Brugia malayi hypothetical protein 0.0127 0.4822 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.003 0.0919 0.085
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0073 0.2678 0.2678
Brugia malayi hypothetical protein 0.0014 0.0283 0.0587
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.003 0.0919 0.085
Loa Loa (eye worm) GABA receptor subunit 0.0016 0.0373 0.0773
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.003 0.0919 0.085
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0584 0.2381
Brugia malayi EGF-like domain containing protein 0.0012 0.0233 0.0484
Brugia malayi nuclear hormone receptor 0.0008 0.0075 0.0156
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0024 0.0706 0.2637
Loa Loa (eye worm) hypothetical protein 0.0016 0.0373 0.0773
Brugia malayi Calcium binding EGF domain containing protein 0.0012 0.0233 0.0484
Plasmodium vivax calpain, putative 0.0022 0.0616 1
Brugia malayi Animal haem peroxidase family protein 0.0075 0.2759 0.5722
Brugia malayi Cadherin domain containing protein 0.0012 0.0233 0.0484
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0919 0.1906
Schistosoma mansoni coup transcription factor 0.0008 0.0075 0.0075
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0584 0.9127
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Echinococcus multilocularis glycine receptor subunit beta 0.003 0.0919 0.085
Loa Loa (eye worm) hypothetical protein 0.0014 0.0281 0.0583
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0584 0.5304
Loa Loa (eye worm) hypothetical protein 0.0012 0.0233 0.0484
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0026 0.0776 0.0706
Echinococcus granulosus fibropellin Ia 0.0012 0.0233 0.0159
Echinococcus granulosus glycine receptor subunit beta 0.003 0.0919 0.085
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0616 0.2301
Giardia lamblia Cathepsin B precursor 0.0024 0.0706 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.003 0.0919 0.0919
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0014 0.0281 0.0207
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.003 0.0919 0.1906
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0082 0.3024 0.627
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0008 0.0075 0.0156
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0616 0.8724
Echinococcus granulosus protein jagged 1 0.0012 0.0233 0.0159
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Loa Loa (eye worm) hypothetical protein 0.003 0.0919 0.1906
Echinococcus multilocularis calpain 5 0.0022 0.0616 0.0545

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2200 nM Radioligand Binding Assay BINDINGDB. No reference
Ki (binding) = 2200 nM Radioligand Binding Assay BINDINGDB. No reference
Ki (binding) = 3500 nM BindingDB_Patents: Radioligand Binding Assay. HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% FBS, 1x Pen/Strep, 1x NaPyruvate, 10 mM HEPES, 600 ug/ml G418 media on 150 cm2 tissue culture plates, washed with 5 mM EDTA in PBS (HyClone Dulbecco's Phosphate Buffered Saline 1x with Calcium and Magnesium, Cat # SH30264.01, hereafter referred to simply as PBS) and scraped into 50 ml tubes. After centrifugation (2K xG, 5 min at 40 C.), the supernatant was aspirated and the pellets frozen and stored at -80 C. Cells were resuspended in PBS in the presence of 1 tablet of protease inhibitor cocktail (Roche, Cat. #11836145001) per 50 mL. Each cell pellet from a 15 cm plate was resuspended in 10 mL, stored on ice, and homogenized for 45 sec just prior to addition to the reactions. Competition binding experiments in 96 well polypropylene plates were performed using [3H]-EMPA (Moraveck Corporation, specific activity=29.6 Ci/mmol). ChEMBL. No reference
Ki (binding) = 3500 nM Radioligand Binding Assay BINDINGDB. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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