Detailed information for compound 1997621

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 476.571 | Formula: C26H32N6O3
  • H donors: 0 H acceptors: 4 LogP: 2.96 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]1COCCN1c1nc2nc(ccc2c(n1)N1CCOC[C@@H]1C)c1cccc(c1)C(=O)N(C)C
  • InChi: 1S/C26H32N6O3/c1-17-15-34-12-10-31(17)24-21-8-9-22(19-6-5-7-20(14-19)25(33)30(3)4)27-23(21)28-26(29-24)32-11-13-35-16-18(32)2/h5-9,14,17-18H,10-13,15-16H2,1-4H3/t17-,18-/m0/s1
  • InChiKey: GPPPLYAOZZZHGA-ROUUACIJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0065 0.1775 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0063 0.1658 0.1864
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.2209 0.2283
Onchocerca volvulus 0.0063 0.1658 0.7428
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Brugia malayi protein unc-22 0.0075 0.2209 0.251
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.1775 1
Loa Loa (eye worm) lethal protein 805 0.0063 0.1658 0.1864
Schistosoma mansoni titin 0.0075 0.2209 0.2283
Echinococcus granulosus G1Y162 protein 0.0063 0.1658 0.1602
Brugia malayi Immunoglobulin I-set domain containing protein 0.02 0.7858 0.913
Schistosoma mansoni nephrin 0.0094 0.3057 0.3187
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0094 0.3057 0.3504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.029 0.1303
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0245 0.0209
Echinococcus granulosus neuroglian 0.0094 0.3057 0.301
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.3057 0.3504
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.1286 0.7137
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0031 0.0245 0.018
Brugia malayi Peroxidasin 0.0031 0.0245 0.0209
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0063 0.1658 0.1602
Schistosoma mansoni nephrin 0.0229 0.9151 0.9682
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.3057 0.3504
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0075 0.2209 0.2156
Brugia malayi Prion-like- 0.0031 0.0245 0.0209
Echinococcus multilocularis lachesin 0.0031 0.0245 0.018
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0065 0.1775 1
Brugia malayi myotactin form A 0.0063 0.1658 0.1864
Trypanosoma brucei protein kinase, putative 0.0027 0.0067 0.0377
Brugia malayi hypothetical protein 0.0063 0.1658 0.1864
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.1372 0.1314
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0245 0.0209
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0063 0.1658 0.1864
Schistosoma mansoni immunophilin 0.0065 0.1775 0.1821
Trichomonas vaginalis immunophilin, putative 0.0065 0.1775 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Onchocerca volvulus 0.0063 0.1658 0.7428
Schistosoma mansoni myosin-binding protein-related 0.0075 0.2209 0.2283
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.1775 1
Echinococcus granulosus twitchin 0.0167 0.6339 0.6315
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0065 0.1775 0.172
Loa Loa (eye worm) TK protein kinase 0.0039 0.0618 0.0645
Schistosoma mansoni ephrin receptor 0.009 0.2879 0.2997
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.2507 0.2859
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0063 0.1658 0.1602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0162 0.0554
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0173 0.6637 0.6615
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Schistosoma mansoni cell adhesion molecule 0.0094 0.3057 0.3187
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0065 0.1775 1
Loa Loa (eye worm) hypothetical protein 0.0217 0.8601 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.1286 0.1228
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Schistosoma mansoni tyrosine kinase 0.0058 0.1466 0.1492
Schistosoma mansoni factor for adipocyte differentiation 0.0063 0.1658 0.1696
Schistosoma mansoni cell adhesion molecule 0.0031 0.0245 0.019
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0063 0.1658 0.1602
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.1286 0.13
Loa Loa (eye worm) hypothetical protein 0.0173 0.6637 0.77
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0031 0.0245 0.0833
Echinococcus granulosus titin 0.0075 0.2209 0.2156
Echinococcus multilocularis titin 0.0075 0.2209 0.2156
Schistosoma mansoni factor for adipocyte differentiation 0.0063 0.1658 0.1696
Brugia malayi Lethal protein 805 0.0063 0.1658 0.1864
Loa Loa (eye worm) hypothetical protein 0.0094 0.3057 0.3504
Schistosoma mansoni cell adhesion molecule 0.0236 0.9449 1
Echinococcus multilocularis roundabout 2 0.0094 0.3057 0.301
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0245 0.0209
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0063 0.1658 0.1602
Giardia lamblia GTOR 0.0054 0.1286 0.7137
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0063 0.1658 0.1602
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0031 0.0245 0.019
Schistosoma mansoni immunophilin 0.0065 0.1775 0.1821
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0063 0.1658 0.1696
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0063 0.1658 0.1696
Echinococcus granulosus contactin 0.0094 0.3057 0.301
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0065 0.1775 1
Echinococcus granulosus defective proboscis extension response 0.0154 0.5789 0.576
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) FKBP5 protein 0.0065 0.1775 0.2002
Echinococcus multilocularis transfer RNA-Phe 0.0075 0.2209 0.2156
Loa Loa (eye worm) hypothetical protein 0.0217 0.8601 1
Echinococcus granulosus neuroglian 0.0167 0.6339 0.6315
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0063 0.1658 0.1602
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0065 0.1775 0.1821
Brugia malayi Protein-tyrosine phosphatase 0.0063 0.1658 0.1864
Brugia malayi Fibronectin type III domain containing protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0075 0.2209 0.251
Echinococcus granulosus nephrin 0.0075 0.2209 0.2156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0929 0.5049
Echinococcus multilocularis neuroglian 0.0094 0.3057 0.301
Onchocerca volvulus 0.0063 0.1658 0.7428
Schistosoma mansoni cell adhesion molecule 0.0075 0.2209 0.2283
Echinococcus granulosus titin 0.0075 0.2209 0.2156
Echinococcus multilocularis Immunoglobulin 0.0154 0.5789 0.576
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0063 0.1658 0.1696
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0063 0.1658 0.1864
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0789 0.4226
Echinococcus granulosus Netrin receptor DCC 0.0063 0.1658 0.1602
Echinococcus granulosus anosmin 1 0.0063 0.1658 0.1602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.4214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1286 0.7137
Onchocerca volvulus 0.0063 0.1658 0.7428
Schistosoma mansoni titin 0.0031 0.0245 0.019
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0.1775 1
Schistosoma mansoni factor for adipocyte differentiation 0.0063 0.1658 0.1696
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.1286 0.1429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1286 0.7137
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0065 0.1775 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0063 0.1658 0.1602
Loa Loa (eye worm) TK/ROR protein kinase 0.0039 0.0618 0.0645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.043 0.2126
Loa Loa (eye worm) hypothetical protein 0.0217 0.8601 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0094 0.3057 0.3504
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Brugia malayi Fibronectin type III domain containing protein 0.0063 0.1658 0.1864
Schistosoma mansoni vesicular amine transporter 0.0154 0.5789 0.6098
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0245 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0164 0.0566
Echinococcus granulosus EG95 0.0063 0.1658 0.1602
Echinococcus multilocularis titin 0.0063 0.1658 0.1602
Echinococcus multilocularis hemicentin 1 0.0031 0.0245 0.018
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0065 0.1775 0.172
Schistosoma mansoni tripartite motif protein trim9 0.0063 0.1658 0.1696
Echinococcus multilocularis peroxidasin 0.0031 0.0245 0.018
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0027 0.0067 0.0377
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.1286 0.7245
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0063 0.1658 0.1696
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0065 0.1775 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.5789 0.6705
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Brugia malayi myotactin form B 0.0063 0.1658 0.1864
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.4214
Leishmania major peptidylprolyl isomerase-like protein 0.0065 0.1775 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0245 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0162 0.0554
Brugia malayi SPRY domain containing protein 0.0063 0.1658 0.1864
Onchocerca volvulus 0.0063 0.1658 0.7428
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.1286 0.1429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1286 0.7137
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0661 1
Echinococcus multilocularis anosmin 1 0.0063 0.1658 0.1602
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0075 0.2209 0.251
Echinococcus multilocularis Netrin receptor DCC 0.0063 0.1658 0.1602
Echinococcus granulosus fibronectin type III domain-containing protein 0.0063 0.1658 0.1602
Leishmania major fk506-binding protein 1-like protein 0.0065 0.1775 1
Schistosoma mansoni hypothetical protein 0.0063 0.1658 0.1696
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0094 0.3057 0.3187
Echinococcus multilocularis roundabout 2 0.0248 1 1
Schistosoma mansoni titin 0.0063 0.1658 0.1696
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0063 0.1658 0.1602
Schistosoma mansoni protein tyrosine phosphatase 0.0063 0.1658 0.1696
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0094 0.3057 0.301
Echinococcus multilocularis anosmin 1 0.0063 0.1658 0.1602
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0063 0.1658 0.1864
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0065 0.1775 1
Echinococcus multilocularis cell adhesion molecule 0.0063 0.1658 0.1602
Trypanosoma brucei Pseudokinase, putative 0.0027 0.0067 0.0377
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0154 0.5789 0.576
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0067 0.0377
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Schistosoma mansoni titin 0.0075 0.2209 0.2283
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0.1775 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0081 0.2507 0.2859
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.1286 0.7245
Brugia malayi Lethal protein 805 0.0063 0.1658 0.1864
Onchocerca volvulus 0.0063 0.1658 0.7428
Loa Loa (eye worm) hypothetical protein 0.0186 0.7188 0.8345
Schistosoma mansoni roundabout 0.0031 0.0245 0.019
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.1286 0.7137
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Leishmania major hypothetical protein, conserved 0.0063 0.1658 0.9312
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0094 0.3057 0.301
Brugia malayi Fibronectin type III domain containing protein 0.0217 0.8601 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.2209 0.251
Echinococcus granulosus Fibronectin type III 0.0063 0.1658 0.1602
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.1775 1
Onchocerca volvulus Tyrosine kinase homolog 0.0039 0.0618 0.2572
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Echinococcus granulosus usherin 0.0063 0.1658 0.1602
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.1775 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0039 0.0618 0.0554
Trypanosoma brucei Flagellum attachment zone protein 20 0.0027 0.0067 0.0377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0164 0.0566
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0063 0.1658 0.9312
Onchocerca volvulus 0.0075 0.2209 1
Echinococcus multilocularis usherin 0.0063 0.1658 0.1602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.4214
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0039 0.0618 0.0554
Onchocerca volvulus 0.0063 0.1658 0.7428
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.1286 0.7137
Brugia malayi Fibronectin type III domain containing protein 0.0063 0.1658 0.1864
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0065 0.1775 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0063 0.1658 0.1602
Loa Loa (eye worm) myotactin form A 0.0063 0.1658 0.1864
Schistosoma mansoni hypothetical protein 0.0063 0.1658 0.1696
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0063 0.1658 0.1602
Echinococcus granulosus hemicentin 1 0.0031 0.0245 0.018
Echinococcus granulosus peroxidasin 0.0031 0.0245 0.018
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.1286 0.7137
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.1286 0.7137
Schistosoma mansoni cell adhesion molecule 0.0094 0.3057 0.3187
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0075 0.2209 0.251
Schistosoma mansoni septate junction protein 0.0031 0.0245 0.019
Onchocerca volvulus 0.0075 0.2209 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.1286 0.7137
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.1775 1
Echinococcus granulosus anosmin 1 0.0063 0.1658 0.1602
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0065 0.1775 0.2002
Echinococcus granulosus roundabout 2 0.0094 0.3057 0.301
Echinococcus granulosus tyrosine protein kinase otk 0.0031 0.0245 0.018
Loa Loa (eye worm) hypothetical protein 0.0075 0.2209 0.251
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.4214
Echinococcus granulosus anosmin 1 0.0063 0.1658 0.1602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0304 0.1388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0304 0.1388
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Echinococcus multilocularis roundabout 2 0.0094 0.3057 0.301
Echinococcus granulosus insulin growth factor 1 receptor beta 0.009 0.2879 0.2831
Loa Loa (eye worm) hypothetical protein 0.0186 0.7188 0.8345
Loa Loa (eye worm) CAMK protein kinase 0.0075 0.2209 0.251
Onchocerca volvulus 0.0075 0.2209 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0065 0.1775 0.172
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Echinococcus granulosus roundabout 2 0.0094 0.3057 0.301
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.1286 0.1228
Echinococcus multilocularis fk506 binding protein 0.0065 0.1775 0.172
Echinococcus granulosus lachesin 0.0031 0.0245 0.018
Loa Loa (eye worm) hypothetical protein 0.0154 0.5789 0.6705
Onchocerca volvulus 0.0063 0.1658 0.7428
Loa Loa (eye worm) projectin 0.0075 0.2209 0.251
Schistosoma mansoni immunophilin 0.0056 0.1372 0.1391
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0063 0.1658 0.1864
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0618 0.0645
Schistosoma mansoni hemicentin 0.0075 0.2209 0.2283
Echinococcus multilocularis Netrin receptor DCC 0.0063 0.1658 0.1602
Echinococcus granulosus Netrin receptor DCC 0.0063 0.1658 0.1602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.029 0.1303
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Echinococcus multilocularis anosmin 1 0.0063 0.1658 0.1602
Onchocerca volvulus 0.0063 0.1658 0.7428
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Schistosoma mansoni neuroglian 0.0094 0.3057 0.3187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0483 0.2434
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0063 0.1658 0.9338
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.009 0.2879 0.2831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0164 0.0566
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0094 0.3057 0.301
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Loa Loa (eye worm) UNCoordinated family member 0.0063 0.1658 0.1864
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0094 0.3057 0.301
Echinococcus multilocularis Immunoglobulin 0.0154 0.5789 0.576
Echinococcus multilocularis hemicentin 1 0.0031 0.0245 0.018
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0245 0.0209
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Loa Loa (eye worm) hypothetical protein 0.0154 0.5789 0.6705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0304 0.1388
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0789 0.4444
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0063 0.1658 0.9312
Onchocerca volvulus 0.0063 0.1658 0.7428
Schistosoma mansoni cell adhesion molecule 0.0075 0.2209 0.2283
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0075 0.2209 0.251
Onchocerca volvulus 0.0063 0.1658 0.7428
Echinococcus multilocularis neuroglian 0.0167 0.6339 0.6315
Brugia malayi Fibronectin type III domain containing protein 0.0063 0.1658 0.1864
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0789 0.4226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0164 0.0566
Echinococcus granulosus cell adhesion molecule 0.0063 0.1658 0.1602
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0063 0.1658 0.1864
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Schistosoma mansoni septate junction protein 0.0031 0.0245 0.019
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.3057 0.3504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0162 0.0554
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0065 0.1775 0.2002
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0154 0.5789 0.6098
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.4214
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0081 0.2507 0.2456
Echinococcus multilocularis Fibronectin, type III 0.0063 0.1658 0.1602
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0154 0.5789 0.6098
Echinococcus granulosus Fibronectin type III domain containing protein 0.0063 0.1658 0.1602
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Schistosoma mansoni hypothetical protein 0.0075 0.2209 0.2283
Brugia malayi Fibronectin type III domain containing protein 0.0063 0.1658 0.1864
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.1775 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0245 0.0209
Echinococcus granulosus Immunoglobulin 0.0154 0.5789 0.576
Trichomonas vaginalis fk506-binding protein, putative 0.0065 0.1775 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0094 0.3057 0.301
Echinococcus multilocularis tyrosine protein kinase otk 0.0031 0.0245 0.018
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0081 0.2507 0.2456
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0065 0.1775 0.2002
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.1658 0.9312
Loa Loa (eye worm) TK/KIN16 protein kinase 0.02 0.7858 0.913
Brugia malayi Immunoglobulin I-set domain containing protein 0.0217 0.8601 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.1372 0.1314
Loa Loa (eye worm) hypothetical protein 0.0056 0.1372 0.153
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0245 0.0209
Brugia malayi hypothetical protein 0.0217 0.8601 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 90 nM BindingDB_Patents: Alternative Enzyme Assay. The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibit phosphorylation by recombinant mTOR.Test compounds were prepared as 10 mM stock solutions in DMSO and diluted into water as required to give a range of final assay concentrations. Aliquots (2 ul) of each compound dilution were placed into a well of a Greiner 384-well low volume (LV) white polystyrene plate (Greiner Bio-one). A 10 ul mixture of recombinant purified mTOR enzyme, 1 uM biotinylated peptide substrate (Biotin-Ahx-Lys-Lys-Ala-Asn-Gln-Val-Phe-Leu-Gly-Phe-Thr-Tyr-Val-Ala-Pro-Ser-Val-Leu-Glu-Ser-Val-Lys-Glu-NH2; Bachem UK Ltd), ATP (20 uM) in a buffer solution [comprising Tris-HCl pH7.4 buffer (50 mM), EGTA (0.1 mM), bovine serum albumin (0.5 mg/ml), DTT (1.25 mM) and manganese chloride (10 mM)] were added to the assay plates and incubated with compound for 2 hours at room temperature. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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