Detailed information for compound 208514

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 649.049 | Formula: C27H22ClF5N2O5S2
  • H donors: 2 H acceptors: 4 LogP: 6.61 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1C[C@H]1[C@@H](O)c2cc(OCc3sc4c(n3)cc(c(c4)F)F)ccc2OC1(C)C)NS(=O)(=O)C(F)(F)F
  • InChi: 1S/C27H22ClF5N2O5S2/c1-26(2)17(8-13-7-14(3-5-18(13)28)35-42(37,38)27(31,32)33)25(36)16-9-15(4-6-22(16)40-26)39-12-24-34-21-10-19(29)20(30)11-23(21)41-24/h3-7,9-11,17,25,35-36H,8,12H2,1-2H3/t17-,25-/m0/s1
  • InChiKey: IKNKBOLYHCLBJX-GKVSMKOHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Cysteinyl leukotriene receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis neuropeptide receptor Cysteinyl leukotriene receptor 1   340 aa 300 aa 24.7 %
Echinococcus multilocularis allatostatin A receptor Cysteinyl leukotriene receptor 1   340 aa 318 aa 23.6 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 303 aa 21.1 %
Brugia malayi GnHR receptor homolog Cysteinyl leukotriene receptor 1   340 aa 317 aa 19.2 %
Schistosoma mansoni neuropeptide receptor Cysteinyl leukotriene receptor 1   340 aa 302 aa 23.8 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 280 aa 26.8 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Cysteinyl leukotriene receptor 1   340 aa 313 aa 21.4 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 304 aa 22.0 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Cysteinyl leukotriene receptor 1   340 aa 307 aa 25.1 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 317 aa 25.2 %
Echinococcus granulosus tachykinin peptides receptor 99D Cysteinyl leukotriene receptor 1   340 aa 309 aa 22.3 %
Schistosoma mansoni opsin-like receptor Cysteinyl leukotriene receptor 1   340 aa 324 aa 23.8 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 298 aa 21.5 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 311 aa 19.3 %
Schistosoma mansoni neuropeptide F-like receptor Cysteinyl leukotriene receptor 1   340 aa 279 aa 21.1 %
Loa Loa (eye worm) neuropeptide F receptor Cysteinyl leukotriene receptor 1   340 aa 309 aa 23.0 %
Schistosoma mansoni peptide (allatostatin)-like receptor Cysteinyl leukotriene receptor 1   340 aa 309 aa 26.5 %
Echinococcus granulosus neuropeptide receptor Cysteinyl leukotriene receptor 1   340 aa 299 aa 24.1 %
Onchocerca volvulus Programmed cell death protein 5 homolog Cysteinyl leukotriene receptor 1   340 aa 286 aa 23.8 %
Onchocerca volvulus Cysteinyl leukotriene receptor 1   340 aa 317 aa 19.9 %
Echinococcus granulosus allatostatin A receptor Cysteinyl leukotriene receptor 1   340 aa 330 aa 23.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0053 0.0052
Echinococcus granulosus potassium large conductance calcium activated 0.0023 0.0065 0.0064
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.008 0.0378 0.0558
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus potassium voltage gated channel protein 0.0023 0.0065 0.0064
Brugia malayi hypothetical protein 0.002 0.005 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Echinococcus granulosus transient receptor potential cation channel 0.0023 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0026 0.0082 0.0082
Toxoplasma gondii transporter, cation channel family protein 0.0023 0.0065 0.1542
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0104 0.0506 0.0505
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0023 0.0065 0.0214
Brugia malayi M-phase phosphoprotein, mpp8 0.0102 0.0493 0.1648
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0073
Echinococcus multilocularis sodium leak channel non selective protein 0.0023 0.0065 0.0064
Schistosoma mansoni hypothetical protein 0.0015 0.0022 0.0022
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0065 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0506 0.0506
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0506 0.0506
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0023 0.0065 0.1772
Echinococcus granulosus hypothetical protein 0.0104 0.0506 0.0505
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0065 0.0065
Schistosoma mansoni voltage-gated ion channel 0.0023 0.0065 0.0065
Echinococcus granulosus glutamate receptor NMDA 0.0493 0.262 0.262
Schistosoma mansoni growth hormone secretagogue receptor 0.0104 0.0506 0.0506
Echinococcus multilocularis potassium voltage gated channel protein 0.0023 0.0065 0.0064
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0023 0.0065 0.0064
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0376 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0104 0.0506 0.1692
Brugia malayi Calcitonin receptor-like protein seb-1 0.0034 0.0124 0.0413
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.012
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0056 0.0244 0.1737
Loa Loa (eye worm) RGS-3 protein 0.002 0.005 0.0073
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0077 0.0077
Schistosoma mansoni neuropeptide f receptor 76f 0.0104 0.0506 0.0506
Loa Loa (eye worm) RGC/RGC protein kinase 0.0077 0.0362 0.0534
Brugia malayi Transient-receptor-potential like protein 0.0023 0.0065 0.0214
Echinococcus multilocularis lamin 0.0027 0.0088 0.0087
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0073
Echinococcus granulosus potassium voltage gated channel protein 0.0023 0.0065 0.0064
Schistosoma mansoni tyrosine kinase 0.0077 0.0362 0.0362
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0023 0.0065 0.0214
Echinococcus multilocularis fmrfamide receptor 0.0104 0.0506 0.0505
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0023 0.0065 0.0214
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0378 0.0378
Onchocerca volvulus 0.0104 0.0506 0.1478
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0023 0.0065 0.0064
Echinococcus granulosus Ankyrin repeat domain containing protein 0.009 0.0431 0.043
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0137
Loa Loa (eye worm) voltage-gated calcium channel 0.0023 0.0065 0.0095
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0003 0.0006
Brugia malayi Cyclic-nucleotide gated cation channel 0.0026 0.0082 0.027
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0026 0.0082 0.0081
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0023 0.0065 0.0064
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0104 0.0506 0.0505
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0066 0.0065
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0077 0.0362 0.036
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Trichomonas vaginalis STE family protein kinase 0.0079 0.0369 0.1075
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0051 0.0074
Echinococcus multilocularis potassium voltage gated channel protein 0.0023 0.0065 0.0064
Brugia malayi cation channel family protein 0.0023 0.0065 0.0214
Echinococcus multilocularis axis inhibition protein axin 0.002 0.005 0.0049
Echinococcus granulosus thioredoxin glutathione reductase 0.0025 0.0075 0.0074
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0028 0.0093 0.0309
Loa Loa (eye worm) G-protein coupled receptor 0.0104 0.0506 0.0748
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0023 0.0065 0.0064
Schistosoma mansoni hypothetical protein 0.0104 0.0506 0.0506
Echinococcus granulosus two pore calcium channel protein 2 0.0023 0.0065 0.0064
Echinococcus multilocularis hyperpolarization activated cyclic 0.0026 0.0082 0.0081
Schistosoma mansoni transient receptor potential channel 0.0023 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus granulosus dro:myosuppressin receptor 0.0104 0.0506 0.0505
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.005 0.0163
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0026 0.0082 0.012
Echinococcus granulosus alpha 1A adrenergic receptor 0.0104 0.0506 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0137
Brugia malayi Thioredoxin reductase 0.0024 0.0074 0.0243
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0268 0.1397 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 0.0082 0.0082
Toxoplasma gondii transporter, cation channel family protein 0.0023 0.0065 0.1542
Brugia malayi hypothetical protein 0.0102 0.0494 0.165
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0104 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Plasmodium falciparum cysteine repeat modular protein 1 0.0014 0.0016 0.0347
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0014 0.0016 0.0016
Schistosoma mansoni neuropeptide F-like receptor 0.0104 0.0506 0.0506
Trypanosoma cruzi extracellular receptor, putative 0.0077 0.0362 1
Echinococcus multilocularis transfer RNA-Gly 0.0023 0.0065 0.0064
Brugia malayi GnHR receptor homolog 0.0104 0.0506 0.1692
Loa Loa (eye worm) hypothetical protein 0.0331 0.1741 0.2575
Echinococcus granulosus histone acetyltransferase KAT2B 0.0288 0.1508 0.1507
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.005 0.0163
Echinococcus multilocularis tissue type plasminogen activator 0.0014 0.0016 0.0015
Echinococcus granulosus chromobox protein 1 0.0011 0.0003 0.0002
Leishmania major cytochrome p450-like protein 0.002 0.0051 0.0286
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0062 0.0277 1
Echinococcus multilocularis serotonin receptor 0.1255 0.6759 0.6759
Echinococcus granulosus chromobox protein 2 0.0011 0.0003 0.0002
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0183 0.0182
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0017
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0023 0.0065 0.2054
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Echinococcus multilocularis G protein coupled receptor 139 0.0104 0.0506 0.0505
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0104 0.0506 0.0506
Echinococcus granulosus 7TM GPCR rhodopsin 0.0104 0.0506 0.0505
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0023 0.0065 0.1772
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0104 0.0506 0.0505
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0023 0.0065 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0137
Echinococcus multilocularis voltage gated potassium channel 0.0028 0.0093 0.0092
Plasmodium vivax SET domain protein, putative 0.008 0.0378 0.9093
Schistosoma mansoni ryanodine receptor related 0.0023 0.0065 0.0065
Schistosoma mansoni chromobox protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0023
Echinococcus multilocularis glutamate receptor 2 0.0156 0.0791 0.079
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0023 0.0065 0.0214
Loa Loa (eye worm) TK/ROR protein kinase 0.0014 0.0016 0.0023
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0023 0.0065 0.0064
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0003 0.000000000037433
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0415 0.0414
Loa Loa (eye worm) hypothetical protein 0.0077 0.0362 0.0534
Echinococcus granulosus atrial natriuretic peptide receptor 0.0077 0.0362 0.036
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0023 0.0065 0.0065
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0023 0.0065 0.0214
Echinococcus multilocularis dual specificity 0.0068 0.0312 0.0311
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0065 0.1542
Echinococcus granulosus receptor type guanylyl cyclase 0.0077 0.0362 0.036
Echinococcus granulosus g-protein coupled receptor 0.0104 0.0506 0.0505
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.005 0.0049
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0077 0.0362 0.0534
Echinococcus multilocularis somatostatin receptor 0.0104 0.0506 0.0505
Onchocerca volvulus 0.0102 0.0493 0.1439
Echinococcus granulosus glutamate NMDA receptor subunit 0.0343 0.1804 0.1803
Brugia malayi Bloom's syndrome protein homolog 0.0014 0.0016 0.0049
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0022 0.0021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.008 0.0378 0.0377
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0104 0.0506 0.0506
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0003 0.00000000034208
Echinococcus granulosus hypothetical protein 0.0023 0.0065 0.0064
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0297 0.1554 0.1553
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.005 0.0049
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0023 0.0065 0.0064
Echinococcus multilocularis neuropeptide receptor A26 0.0104 0.0506 0.0505
Loa Loa (eye worm) melatonin receptor type 1A 0.0104 0.0506 0.0748
Onchocerca volvulus 0.0104 0.0506 0.1478
Schistosoma mansoni glutamate receptor NMDA 0.0801 0.4291 0.4291
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0034 0.0124 0.0413
Schistosoma mansoni lamin 0.0027 0.0088 0.0088
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0104 0.0506 0.1692
Echinococcus granulosus neuropeptide receptor 0.0104 0.0506 0.0505
Echinococcus granulosus g protein coupled receptor 0.0104 0.0506 0.0505
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0053 0.0078
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.005 0.0049
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0003
Brugia malayi hypothetical protein 0.0104 0.0506 0.1692
Loa Loa (eye worm) hypothetical protein 0.0027 0.0085 0.0125
Echinococcus granulosus intermediate filament protein 0.0027 0.0088 0.0087
Brugia malayi hypothetical protein 0.002 0.005 0.0163
Brugia malayi G-protein coupled receptor 0.0104 0.0506 0.1692
Echinococcus multilocularis neuropeptide s receptor 0.0104 0.0506 0.0505
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0056 0.0244 0.1737
Echinococcus granulosus neuropeptide Y receptor 0.0104 0.0506 0.0505
Echinococcus multilocularis chromobox protein 1 0.0011 0.0003 0.0002
Schistosoma mansoni vesicular amine transporter 0.0023 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0068 0.0308 0.0455
Loa Loa (eye worm) hypothetical protein 0.0077 0.0362 0.0534
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0051 0.1379
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0026 0.0082 0.0081
Echinococcus multilocularis shaker cognate 0.0023 0.0065 0.0064
Brugia malayi Protein cec-1. 0.0011 0.0003 0.0006
Echinococcus granulosus neuropeptide receptor 0.0104 0.0506 0.0505
Brugia malayi hypothetical protein 0.0104 0.0506 0.1692
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus granulosus fmrfamide receptor 0.0104 0.0506 0.0505
Onchocerca volvulus 0.0104 0.0506 0.1478
Loa Loa (eye worm) hypothetical protein 0.0077 0.0362 0.0534
Echinococcus multilocularis lamin dm0 0.0027 0.0088 0.0087
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.005 0.0049
Echinococcus granulosus two pore calcium channel protein 1 0.0023 0.0065 0.0064
Brugia malayi follicle stimulating hormone receptor 0.0104 0.0506 0.1692
Echinococcus multilocularis Ankyrin 0.0015 0.0023 0.0022
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0068 0.0312 0.8624
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0506 0.0506
Echinococcus multilocularis neuropeptide Y receptor 0.0104 0.0506 0.0505
Schistosoma mansoni axis inhibition protein axin 0.002 0.005 0.005
Echinococcus multilocularis sex peptide receptor 0.0104 0.0506 0.0505
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0026 0.0082 0.012
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Schistosoma mansoni metabotropic glutamate receptor 0.0077 0.0362 0.0362
Schistosoma mansoni hypothetical protein 0.0023 0.0066 0.0066
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0268 0.1397 0.5
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Schistosoma mansoni regulator of G protein signaling 0.002 0.005 0.005
Echinococcus multilocularis neuropeptide receptor 0.0104 0.0506 0.0505
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0022 0.0021
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.005 0.0049
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0022 0.0057
Echinococcus multilocularis transient receptor potential gamma protein 0.0023 0.0065 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0003 0.000000000037433
Echinococcus granulosus potassium voltage gated channel protein 0.0023 0.0065 0.0064
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0023 0.0065 0.0065
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0003 0.000000000037433
Brugia malayi CHD4 protein 0.0011 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0023 0.0065 0.0214
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0376 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0003 0.0047
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.009 0.0431 0.043
Echinococcus granulosus voltage dependent calcium channel 0.0023 0.0065 0.0064
Echinococcus granulosus neuropeptide Y receptor 0.0104 0.0506 0.0505
Brugia malayi Protein kinase domain containing protein 0.0014 0.0016 0.005
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0003 0.00000000030928
Mycobacterium tuberculosis Probable dehydrogenase 0.0056 0.0244 0.1737
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0312 0.8292
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0378 0.0378
Echinococcus multilocularis short transient receptor potential channel 6 0.0023 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0051 0.1379
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0053 0.0078
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0022 0.0021
Echinococcus multilocularis glutamate receptor 2 0.0307 0.1612 0.1611
Loa Loa (eye worm) hypothetical protein 0.0034 0.0124 0.0183
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0023 0.0065 0.0064
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0023 0.0065 0.0064
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.0073
Brugia malayi glutathione reductase 0.0024 0.0074 0.0243
Schistosoma mansoni biogenic amine receptor 0.0104 0.0506 0.0506
Echinococcus granulosus g protein coupled receptor 0.0104 0.0506 0.0505
Echinococcus granulosus sodium leak channel non selective protein 0.0023 0.0065 0.0064
Brugia malayi hypothetical protein 0.0104 0.0506 0.1692
Schistosoma mansoni voltage-gated cation channel 0.0023 0.0065 0.0065
Entamoeba histolytica protein kinase, putative 0.0068 0.0312 0.8292
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0359 0.0358
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0104 0.0506 0.1692
Loa Loa (eye worm) ion channel NompC 0.0023 0.0065 0.0095
Echinococcus granulosus Chromo domain 0.0011 0.0003 0.0002
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.1887
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0034 0.0124 0.0183
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0104 0.0506 0.0506
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0307 0.1612 0.1611
Echinococcus granulosus nmda type glutamate receptor 0.0571 0.3041 0.304
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 0.0082 0.0082
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0104 0.0506 0.0506
Schistosoma mansoni amine GPCR 0.0104 0.0506 0.0506
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0065 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0023 0.0065 0.0064
Echinococcus multilocularis neuropeptides capa receptor 0.0104 0.0506 0.0505
Echinococcus multilocularis g protein coupled receptor 0.0104 0.0506 0.0505
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0053 0.0053
Loa Loa (eye worm) RecQ helicase 0.0014 0.0016 0.0022
Schistosoma mansoni opsin-like receptor 0.0104 0.0506 0.0506
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0307 0.1612 0.1611
Brugia malayi ORL1-like opioid receptor 0.0104 0.0506 0.1692
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0003 0.000000000037433
Echinococcus granulosus transient receptor potential cation channel 0.0023 0.0065 0.0064
Toxoplasma gondii transporter, cation channel family protein 0.0023 0.0065 0.1542
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0297 0.1554 0.1554
Echinococcus granulosus glutamate receptor subunit protein glur 0.0151 0.0761 0.076
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Entamoeba histolytica hypothetical protein 0.002 0.005 0.125
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Schistosoma mansoni glutamate receptor AMPA 0.023 0.1191 0.1191
Echinococcus multilocularis potassium large conductance calcium activated 0.0023 0.0065 0.0064
Brugia malayi Receptor family ligand binding region containing protein 0.0077 0.0362 0.1207
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.002 0.0028
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0022 0.0032
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0026 0.0082 0.0081
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0151 0.0761 0.076
Leishmania major trypanothione reductase 0.0024 0.0074 0.0417
Schistosoma mansoni neuropeptide F-like receptor 0.0104 0.0506 0.0506
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.008 0.0378 0.9098
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0104 0.0506 0.0505
Brugia malayi hypothetical protein 0.0104 0.0506 0.1692
Echinococcus multilocularis neuropeptide Y receptor 0.0104 0.0506 0.0505
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0023 0.0065 0.2054
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0079 0.0369 0.889
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0023 0.0065 0.0182
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0073
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0415 0.121
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0082 0.0231
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Echinococcus multilocularis sodium channel protein 0.0331 0.1739 0.1738
Brugia malayi neuropeptide F receptor 0.0104 0.0506 0.1692
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.002 0.0062
Toxoplasma gondii kringle domain-containing protein 0.0014 0.0016 0.0359
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Schistosoma mansoni two-pore calcium channel 0.0023 0.0065 0.0065
Echinococcus multilocularis glutamate receptor NMDA 0.0493 0.262 0.262
Brugia malayi voltage-dependent calcium channel 0.0023 0.0065 0.0214
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Plasmodium vivax glutathione reductase, putative 0.0024 0.0074 0.1712
Echinococcus granulosus serotonin receptor 0.0104 0.0506 0.0505
Echinococcus granulosus voltage gated potassium channel 0.0023 0.0065 0.0064
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Echinococcus multilocularis conserved hypothetical protein 0.0023 0.0065 0.0064
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0104 0.0506 0.0505
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0104 0.0506 0.1478
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0026 0.0082 0.0081
Onchocerca volvulus 0.0077 0.0362 0.1053
Loa Loa (eye worm) voltage-gated potassium channel 0.0023 0.0065 0.0095
Brugia malayi G-protein coupled receptor 0.0104 0.0506 0.1692
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0137
Echinococcus multilocularis Chromo domain 0.0011 0.0003 0.0002
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0415 1
Loa Loa (eye worm) neuropeptide F receptor 0.0104 0.0506 0.0748
Echinococcus multilocularis potassium voltage gated channel protein 0.0023 0.0065 0.0064
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1851 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0415 1
Toxoplasma gondii thioredoxin reductase 0.0024 0.0074 0.1751
Schistosoma mansoni biogenic amine (5HT) receptor 0.1851 1 1
Echinococcus multilocularis neuropeptide receptor 0.0104 0.0506 0.0505
Echinococcus multilocularis voltage dependent calcium channel 0.0023 0.0065 0.0064
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.0003 0.0002
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0023 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0062 0.0277 0.1979
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0104 0.0506 0.0506
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0065 0.0065
Onchocerca volvulus 0.0104 0.0506 0.1478
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0023 0.0065 0.0064
Brugia malayi Heterochromatin protein 1 0.0011 0.0003 0.0006
Echinococcus multilocularis hyperpolarization activated cyclic 0.0026 0.0082 0.0081
Schistosoma mansoni regulator of G protein signaling 0.002 0.005 0.005
Onchocerca volvulus 0.0014 0.0016 0.0038
Echinococcus multilocularis short transient receptor potential channel 6 0.0023 0.0065 0.0064
Onchocerca volvulus 0.0104 0.0506 0.1478
Echinococcus granulosus histone lysine methyltransferase setb 0.008 0.0378 0.0377
Brugia malayi hypothetical protein 0.0104 0.0506 0.1692
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0024 0.0074 0.0519
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0307 0.1612 0.1611
Brugia malayi PXA domain containing protein 0.002 0.005 0.0163
Echinococcus granulosus hyperpolarization activated cyclic 0.0026 0.0082 0.0081
Echinococcus granulosus g protein coupled receptor 0.0104 0.0506 0.0505
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Onchocerca volvulus 0.0104 0.0506 0.1478
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0104 0.0506 0.0748
Loa Loa (eye worm) neuropeptide F receptor 0.0104 0.0506 0.0748
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0059 0.0164
Echinococcus granulosus potassium voltage gated channel protein 0.0023 0.0065 0.0064
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0026 0.0082 0.0081
Schistosoma mansoni amine GPCR 0.0104 0.0506 0.0506
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.1887
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0183 0.0609
Brugia malayi hypothetical protein 0.0104 0.0506 0.1692
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0077 0.0362 0.1053
Onchocerca volvulus 0.0104 0.0506 0.1478
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Loa Loa (eye worm) cytochrome P450 0.0011 0.0001 0.0001
Echinococcus granulosus metabotropic glutamate receptor 2 0.0077 0.0362 0.036
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0104 0.0506 0.0748
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Brugia malayi chromobox protein homolog 3 0.0011 0.0003 0.0006
Echinococcus multilocularis g-protein coupled receptor 0.0104 0.0506 0.0505
Brugia malayi Serotonin receptor 0.0104 0.0506 0.1692
Echinococcus granulosus lamin dm0 0.0027 0.0088 0.0087
Echinococcus granulosus expressed protein 0.039 0.2059 0.2058
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Schistosoma mansoni chromobox protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Schistosoma mansoni regulator of G protein signaling 0.002 0.005 0.005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus multilocularis allatostatin A receptor 0.0104 0.0506 0.0505
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0023 0.0065 0.0064
Schistosoma mansoni voltage-dependent calcium channel 0.0023 0.0065 0.0065
Schistosoma mansoni biogenic amine receptor 0.0104 0.0506 0.0506
Schistosoma mansoni tyrosine kinase 0.0077 0.0362 0.0362
Echinococcus multilocularis serotonin receptor 0.1255 0.6759 0.6759
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0079 0.0369 0.8885
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0023 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0041 0.0166 0.0245
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0023 0.0065 0.0214
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0092 0.044 0.044
Echinococcus granulosus short transient receptor potential channel 6 0.0023 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0068 0.0308 0.0455
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.005 0.0049
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0331 0.1739 0.1738
Echinococcus granulosus voltage dependent calcium channel 0.0023 0.0065 0.0064
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0104 0.0506 0.0505
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0268 0.1397 0.5
Entamoeba histolytica hypothetical protein 0.002 0.005 0.125
Brugia malayi intermediate filament protein 0.0027 0.0088 0.0291
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0077 0.0362 0.036
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0023 0.0065 0.0064
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0003 0.0047
Onchocerca volvulus 0.0104 0.0506 0.1478
Brugia malayi Cytochrome P450 family protein 0.002 0.0051 0.0166
Schistosoma mansoni metabotropic glutamate receptor 0.0077 0.0362 0.0362
Brugia malayi hypothetical protein 0.0023 0.0065 0.0214
Leishmania major hypothetical protein, conserved 0.0014 0.0016 0.0085
Echinococcus granulosus glutamate receptor 2 0.0156 0.0791 0.079
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0024 0.0073 0.0072
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0104 0.0506 0.1692
Onchocerca volvulus 0.0077 0.0362 0.1053
Onchocerca volvulus 0.0104 0.0506 0.1478
Schistosoma mansoni neuropeptide receptor 0.0104 0.0506 0.0506
Schistosoma mansoni amine GPCR 0.0104 0.0506 0.0506
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0431 0.0431
Echinococcus multilocularis axis inhibition protein axin 0.002 0.005 0.0049
Brugia malayi hypothetical protein 0.0104 0.0506 0.1692
Schistosoma mansoni amine GPCR 0.0104 0.0506 0.0506
Onchocerca volvulus 0.0104 0.0506 0.1478
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0378 0.0378
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0023 0.0065 0.0214
Onchocerca volvulus 0.0092 0.044 0.1283
Brugia malayi Dopamine receptor 0.0104 0.0506 0.1692
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Echinococcus multilocularis two pore calcium channel protein 1 0.0023 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0073
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0065 0.0064
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0068 0.0312 1
Loa Loa (eye worm) hypothetical protein 0.1255 0.6759 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0023 0.0065 0.0064
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0023 0.0065 0.0065
Trypanosoma brucei cytochrome P450, putative 0.002 0.0051 0.1599
Echinococcus multilocularis g protein coupled receptor 0.0104 0.0506 0.0505
Schistosoma mansoni biogenic amine (5HT) receptor 0.1255 0.6759 0.6759
Echinococcus granulosus death domain containing protein 0.0015 0.0022 0.0021
Echinococcus granulosus neuropeptides capa receptor 0.0104 0.0506 0.0505
Echinococcus granulosus TRP transient receptor potential channel 0.0023 0.0065 0.0064
Echinococcus multilocularis bloom syndrome protein 0.0014 0.0016 0.0015
Schistosoma mansoni glutamate receptor kainate 0.023 0.1191 0.1191
Loa Loa (eye worm) RGC/RGC protein kinase 0.0077 0.0362 0.0534
Echinococcus granulosus neuropeptides capa receptor 0.0104 0.0506 0.0505
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0431 0.0431
Echinococcus granulosus ryanodine receptor 44f 0.0023 0.0065 0.0064
Brugia malayi Serotonin receptor 0.0104 0.0506 0.1692
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0012 0.0007 0.0097
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0023 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0013
Echinococcus granulosus transient receptor potential cation channel 0.0023 0.0065 0.0064
Echinococcus granulosus metabotropic glutamate receptor 5 0.0077 0.0362 0.036
Echinococcus granulosus voltage gated potassium channel 0.0028 0.0093 0.0092
Loa Loa (eye worm) glutamate receptor 1 0.023 0.1191 0.1761
Echinococcus granulosus Ankyrin 0.0015 0.0023 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0003 0.000000000037433
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0151 0.0761 0.076
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.005 0.0049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0003 0.000000000037433
Schistosoma mansoni netrin receptor unc5 0.0015 0.0022 0.0022
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0307 0.1612 0.1611
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0506 0.0506
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0056 0.0244 0.1737
Onchocerca volvulus 0.0027 0.0088 0.0249
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0065 0.0065
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 0.0082 0.0082
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0077 0.0362 0.0534
Trypanosoma brucei trypanothione reductase 0.0024 0.0074 0.2332
Echinococcus multilocularis receptor type guanylyl cyclase 0.0077 0.0362 0.036
Brugia malayi Pre-SET motif family protein 0.008 0.0378 0.1262
Onchocerca volvulus 0.0104 0.0506 0.1478
Echinococcus granulosus tm gpcr rhodopsin 0.026 0.1352 0.1351
Schistosoma mansoni adenoreceptor 0.0104 0.0506 0.0506
Schistosoma mansoni alpha-1 adrenergic receptor 0.0104 0.0506 0.0506
Echinococcus multilocularis dro:myosuppressin receptor 0.0104 0.0506 0.0505
Echinococcus granulosus transient receptor potential gamma protein 0.0023 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Echinococcus granulosus axis inhibition protein axin 0.002 0.005 0.0049
Echinococcus multilocularis voltage dependent calcium channel 0.0023 0.0065 0.0064
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0023 0.0065 0.0065
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0059 0.0164
Schistosoma mansoni chromobox protein 0.0011 0.0003 0.0003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0077 0.0362 0.0361
Echinococcus granulosus chromobox protein 1 0.0011 0.0003 0.0002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0104 0.0506 0.0505
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0012 0.0011
Brugia malayi Death domain containing protein 0.0015 0.0022 0.0071
Echinococcus granulosus somatostatin receptor 0.0104 0.0506 0.0505
Loa Loa (eye worm) heterochromatin protein 1 0.0011 0.0003 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0003 0.000000000037433
Echinococcus multilocularis g protein coupled receptor 0.0104 0.0506 0.0505
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0065 0.0065
Onchocerca volvulus 0.0104 0.0506 0.1478
Loa Loa (eye worm) helicase 0.0011 0.0003 0.0004
Brugia malayi Receptor family ligand binding region containing protein 0.0077 0.0362 0.1207
Loa Loa (eye worm) hypothetical protein 0.0077 0.0362 0.0534
Echinococcus granulosus glutamate receptor 2 0.0307 0.1612 0.1611
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus granulosus sodium channel protein 0.0331 0.1739 0.1738
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0053 0.0052
Brugia malayi hypothetical protein 0.0104 0.0506 0.1692
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0088 0.0129
Schistosoma mansoni axis inhibition protein axin 0.002 0.005 0.005
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0026 0.0082 0.0081
Brugia malayi G protein-coupled receptor 0.0104 0.0506 0.1692
Schistosoma mansoni transient receptor potential channel 0.0023 0.0065 0.0065
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0307 0.1612 0.1611
Echinococcus multilocularis neuropeptide FF receptor 2 0.0104 0.0506 0.0505
Schistosoma mansoni opsin-like receptor 0.0104 0.0506 0.0506
Echinococcus multilocularis ryanodine receptor 44f 0.0023 0.0065 0.0064
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0056 0.0244 0.8777
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0032
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0022 0.0021
Brugia malayi hypothetical protein 0.0104 0.0506 0.1692
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0022 0.0071
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0183 0.0182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0023 0.0065 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0506 0.0506
Schistosoma mansoni 60S ribosomal protein L21 0.0025 0.0077 0.0077
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0104 0.0506 0.0506
Schistosoma mansoni chromobox protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0023 0.0065 0.0064
Echinococcus multilocularis musashi 0.0027 0.0088 0.0087
Echinococcus multilocularis glutamate receptor 2 0.023 0.1191 0.119
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0028 0.0093 0.0092
Brugia malayi Melatonin receptor type 1A 0.0104 0.0506 0.1692
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0419 0.2218 0.2217
Schistosoma mansoni histamine h1 receptor 0.0104 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Brugia malayi putative neuropeptide receptor NPR1 0.0104 0.0506 0.1692
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0307 0.1612 0.1611
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Loa Loa (eye worm) hypothetical protein 0.1255 0.6759 1
Onchocerca volvulus 0.0023 0.0065 0.0182
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Echinococcus granulosus transient receptor potential cation channel 0.0023 0.0065 0.0064
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0053 0.0053
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) TYRA-2 protein 0.0104 0.0506 0.0748
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0104 0.0506 0.0505
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0068 0.0312 0.0461
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0065 0.0065
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0093 0.0093
Brugia malayi putative neuropeptide receptor 0.0104 0.0506 0.1692
Schistosoma mansoni glutamate receptor NMDA 0.0343 0.1804 0.1804
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0104 0.0506 0.1692
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus multilocularis nmda type glutamate receptor 0.0571 0.3041 0.304
Brugia malayi PXA domain containing protein 0.002 0.005 0.0163
Schistosoma mansoni cytochrome P450 0.0011 0.0001 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0104 0.0506 0.0505
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0068 0.0312 0.8624
Schistosoma mansoni hypothetical protein 0.0023 0.0065 0.0065
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.005 0.0163
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0104 0.0506 0.0506
Entamoeba histolytica hypothetical protein 0.0011 0.0003 0.00000000034208
Echinococcus granulosus tm gpcr rhodopsin 0.0104 0.0506 0.0505
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.005 0.0049
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0023 0.0065 0.0065
Brugia malayi latrophilin 2 splice variant baaae 0.0023 0.0066 0.0219
Loa Loa (eye worm) RGC/RGC protein kinase 0.0077 0.0362 0.0534
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0022 0.0022
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0183 0.027
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0003 0.0003
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0104 0.0506 0.0505
Plasmodium falciparum NIMA related kinase 1 0.0079 0.0369 0.9827
Echinococcus granulosus orexin receptor type 2 0.0104 0.0506 0.0505
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0065 0.0065
Brugia malayi Dopamine receptor protein 1 0.0104 0.0506 0.1692
Leishmania major extracellular receptor, putative 0.0077 0.0362 0.2074
Brugia malayi Guanylyl cyclase protein 23 0.0077 0.0362 0.1207
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0077 0.0362 0.0534
Chlamydia trachomatis glutamine binding protein 0.0268 0.1397 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0065 0.0064
Entamoeba histolytica hypothetical protein 0.002 0.005 0.125
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0343 0.1804 0.1803
Loa Loa (eye worm) hypothetical protein 0.0077 0.0362 0.0534
Schistosoma mansoni protein kinase 0.0077 0.0362 0.0362
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.005 0.005
Schistosoma mansoni neuropeptide receptor 0.0104 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0051 0.0356
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0016 0.0037
Trichomonas vaginalis set domain proteins, putative 0.0638 0.3408 1
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0376 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0104 0.0506 0.0506
Schistosoma mansoni z-protein (S1r protein) 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0077 0.0362 0.0534
Leishmania major hypothetical protein, unknown function 0.0023 0.0065 0.0367
Mycobacterium tuberculosis Probable reductase 0.0056 0.0244 0.1737
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0026 0.0082 0.0081
Mycobacterium tuberculosis Probable oxidoreductase 0.0062 0.0277 0.1979
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0026 0.0082 0.0082
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.005 0.0049
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0065 0.0065
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0023 0.0023
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0104 0.0506 0.0506
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0051 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0003 0.0002
Loa Loa (eye worm) thioredoxin reductase 0.0024 0.0074 0.0108
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0003 0.0002
Loa Loa (eye worm) calcium channel 0.0023 0.0065 0.0095
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0104 0.0506 0.0505
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0023 0.0065 0.0065
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0104 0.0506 0.0505
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Loa Loa (eye worm) ryanodine receptor 0.0023 0.0065 0.0095
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0104 0.0506 0.0505
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0003 0.000000000037433
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0104 0.0506 0.0505
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0065 0.0065
Brugia malayi acetyltransferase, GNAT family protein 0.0297 0.1554 0.52
Loa Loa (eye worm) hypothetical protein 0.0102 0.0494 0.073
Loa Loa (eye worm) G-protein coupled receptor 0.0104 0.0506 0.0748
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0033
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus multilocularis tyrosine kinase 0.0077 0.0362 0.036
Echinococcus multilocularis G-protein coupled receptor, putative 0.0104 0.0506 0.0505
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0023 0.0065 0.0065
Echinococcus granulosus dual specificity 0.0068 0.0312 0.0311
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0151 0.0761 0.076
Brugia malayi Protein kinase domain containing protein 0.0068 0.0312 0.1041
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Brugia malayi metabotropic glutamate receptor type 2 0.0077 0.0362 0.1207
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0023 0.0065 0.0064
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0415 1
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.1887
Echinococcus granulosus axis inhibition protein axin 0.002 0.005 0.0049
Loa Loa (eye worm) glutamate receptor 0.0077 0.0362 0.0534
Brugia malayi Cytochrome P450 family protein 0.002 0.0051 0.0166
Echinococcus granulosus biogenic amine 5HT receptor 0.1255 0.6759 0.6759
Echinococcus granulosus short transient receptor potential channel 6 0.0023 0.0065 0.0064
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0003 0.00000000034208
Entamoeba histolytica hypothetical protein 0.0077 0.0362 0.9622
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.005 0.0073
Toxoplasma gondii hypothetical protein 0.0023 0.0065 0.1542
Onchocerca volvulus Neuropeptide F receptor homolog 0.0104 0.0506 0.1478
Brugia malayi AKH receptor 0.0104 0.0506 0.1692
Loa Loa (eye worm) voltage-gated potassium channel 0.0023 0.0065 0.0095
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0104 0.0506 0.0748
Echinococcus multilocularis two pore calcium channel protein 2 0.0023 0.0065 0.0064
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.0003 0.0002
Plasmodium vivax thioredoxin reductase, putative 0.0024 0.0074 0.1712
Schistosoma mansoni hypothetical protein 0.0104 0.0506 0.0506
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.005 0.0163
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Loa Loa (eye worm) acetyltransferase 0.0297 0.1554 0.2298
Brugia malayi hypothetical protein 0.0077 0.0362 0.1207
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0104 0.0506 0.0505
Schistosoma mansoni hypothetical protein 0.0151 0.0761 0.0761
Schistosoma mansoni lamin 0.0027 0.0088 0.0088
Trichomonas vaginalis DNA helicase recq1, putative 0.0014 0.0016 0.0037
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.0003 0.0004
Loa Loa (eye worm) voltage-dependent calcium channel 0.0023 0.0065 0.0095
Brugia malayi olfactory channel protein osm-9 0.0023 0.0066 0.0216
Schistosoma mansoni glutamate receptor kainate 0.023 0.1191 0.1191
Trypanosoma cruzi trypanothione reductase, putative 0.0024 0.0074 0.2011
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus granulosus hyperpolarization activated cyclic 0.0026 0.0082 0.0081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0415 0.121
Echinococcus granulosus bloom syndrome protein 0.0014 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0077 0.0362 0.0534
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0023 0.0065 0.0214
Echinococcus granulosus lamin 0.0027 0.0088 0.0087
Echinococcus multilocularis regulator of G protein signaling 0.002 0.005 0.0049
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0104 0.0506 0.0506
Brugia malayi G protein-coupled receptor F59B2.13 0.0104 0.0506 0.1692
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.026 0.1352 0.1351
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0023 0.0065 0.0214
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0097
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0307 0.1612 0.1611
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.005 0.0049
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0065 0.0065
Echinococcus granulosus potassium voltage gated channel protein 0.0023 0.0065 0.0064
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0151 0.0761 0.076
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus multilocularis neuropeptides capa receptor 0.0104 0.0506 0.0505
Brugia malayi Dopamine receptor protein 2 0.0104 0.0506 0.1692
Loa Loa (eye worm) hypothetical protein 0.0077 0.0362 0.0534
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0023 0.0065 0.0214
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0013
Entamoeba histolytica protein kinase, putative 0.0068 0.0312 0.8292
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0104 0.0506 0.1692
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0104 0.0506 0.0506
Schistosoma mansoni hypothetical protein 0.0104 0.0506 0.0506
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0104 0.0506 0.1478
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0369 0.1075
Onchocerca volvulus 0.0104 0.0506 0.1478
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0096
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0065 0.0065
Echinococcus multilocularis fmrfamide receptor 0.0104 0.0506 0.0505
Echinococcus multilocularis chromobox protein 2 0.0011 0.0003 0.0002
Echinococcus granulosus neuropeptide receptor A26 0.0104 0.0506 0.0505
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0331 0.1739 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0088 0.0088
Brugia malayi RE15519p 0.0104 0.0506 0.1692
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0077 0.0362 0.036
Leishmania major hypothetical protein, conserved 0.0023 0.0065 0.0367
Toxoplasma gondii hypothetical protein 0.0023 0.0065 0.1542
Brugia malayi Glutamate receptor 2 precursor 0.023 0.1191 0.3985
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0056 0.0244 0.1737
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0023 0.0065 0.0214
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0104 0.0506 0.0506
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0088 0.0291
Entamoeba histolytica hypothetical protein 0.0068 0.0312 0.8292
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0104 0.0506 0.0748
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0082 0.0231
Loa Loa (eye worm) CYP4Cod1 0.002 0.0051 0.0074
Loa Loa (eye worm) hypothetical protein 0.0077 0.0362 0.0534
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0506 0.0506
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0312 0.0312
Brugia malayi cation channel family protein 0.0023 0.0065 0.0214
Schistosoma mansoni opsin-like receptor 0.0104 0.0506 0.0506
Echinococcus granulosus tachykinin peptides receptor 99D 0.0104 0.0506 0.0505
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.005 0.0049
Echinococcus granulosus neuropeptide FF receptor 2 0.0104 0.0506 0.0505
Brugia malayi hypothetical protein 0.0024 0.0073 0.0242
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0028 0.0093 0.0092
Brugia malayi Kringle domain containing protein 0.0014 0.0016 0.005
Brugia malayi SET domain containing protein 0.0014 0.0019 0.006
Brugia malayi ion channel NompC 0.0023 0.0065 0.0214
Brugia malayi Metabotropic glutamate receptor precursor. 0.0077 0.0362 0.1207
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0003 0.000000000037433
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Brugia malayi hypothetical protein 0.0127 0.0632 0.2111
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0023 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0065 0.0064
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0003 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0016 0.0412
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0104 0.0506 0.0505
Echinococcus granulosus transient receptor potential cation channel 0.0023 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Echinococcus granulosus tissue type plasminogen activator 0.0014 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.0129
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0001 0.0001
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0003 0.00000000034208
Schistosoma mansoni biogenic amine receptor 0.0104 0.0506 0.0506
Echinococcus multilocularis thioredoxin glutathione reductase 0.0025 0.0075 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0268 0.1397 1
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0195 0.0195
Echinococcus multilocularis orexin receptor type 2 0.0104 0.0506 0.0505
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0104 0.0506 0.0748
Schistosoma mansoni glutamate receptor kainate 0.023 0.1191 0.1191
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0104 0.0506 0.0506
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0068 0.0312 0.1789
Echinococcus granulosus calcium activated potassium channel 0.0024 0.0069 0.0068
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0195 0.0195
Echinococcus granulosus nmda type glutamate receptor 0.0912 0.4897 0.4897
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0307 0.1612 0.1611
Brugia malayi hypothetical protein 0.0104 0.0506 0.1692
Echinococcus granulosus Chromobox protein 3 0.0011 0.0003 0.0002
Brugia malayi Glutamate receptor 1 precursor 0.023 0.1191 0.3985
Echinococcus granulosus neuropeptide s receptor 0.0104 0.0506 0.0505
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0359 0.0358
Brugia malayi Pre-SET motif family protein 0.0561 0.2987 1
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0073
Loa Loa (eye worm) glutathione reductase 0.0024 0.0074 0.0108
Echinococcus granulosus allatostatin A receptor 0.0104 0.0506 0.0505
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0003 0.000000000037433
Brugia malayi Uncoordinated protein 44 0.0015 0.0022 0.0071
Plasmodium falciparum glutathione reductase 0.0024 0.0074 0.1894
Echinococcus multilocularis chromobox protein 1 0.0011 0.0003 0.0002
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0003 0.0003
Echinococcus multilocularis NMDA receptor 0.0151 0.0761 0.076
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.005 0.0163
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0023 0.0065 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0003 0.000000000037433
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0137
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0024 0.0073 0.0072
Echinococcus granulosus 7tm_1 domain containing protein 0.0104 0.0506 0.0505
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0077 0.0362 0.1207
Echinococcus granulosus shaker cognate 0.0023 0.0065 0.0064
Onchocerca volvulus 0.0027 0.0088 0.0249
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0053 0.0175
Onchocerca volvulus 0.0104 0.0506 0.1478
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.005 0.0073
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0104 0.0506 0.0505
Onchocerca volvulus 0.0102 0.0493 0.1439
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Brugia malayi larval opioid receptor 0.0104 0.0506 0.1692
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0151 0.0761 0.076
Schistosoma mansoni neuropeptide receptor 0.0104 0.0506 0.0506
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0104 0.0506 0.0505
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0506 0.0506
Onchocerca volvulus 0.0638 0.3408 1
Echinococcus granulosus transient receptor potential cation channel 0.0023 0.0066 0.0065
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0014 0.0016 0.0313
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0268 0.1397 0.5
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.005 0.005
Echinococcus multilocularis calcium activated potassium channel 0.0024 0.0069 0.0068
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0028 0.0093 0.0137
Schistosoma mansoni myosin xvIII 0.0104 0.0506 0.0506
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0088 0.0129
Schistosoma mansoni ATP-binding cassette transporter 0.023 0.1191 0.1191
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0023 0.0065 0.0214
Loa Loa (eye worm) hypothetical protein 0.0102 0.0493 0.0729
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.008 0.0378 0.0377
Schistosoma mansoni amine GPCR 0.0104 0.0506 0.0506
Brugia malayi sulfakinin receptor protein 0.0104 0.0506 0.1692
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.0065 0.0064
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0023 0.0065 0.0064
Schistosoma mansoni transient receptor potential channel 4 0.0023 0.0065 0.0065
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0023 0.0065 0.0182
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0023 0.0065 0.0065
Echinococcus granulosus voltage gated hydrogen channel 1 0.0023 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Trichomonas vaginalis conserved hypothetical protein 0.002 0.005 0.0137
Brugia malayi Protein kinase domain containing protein 0.0016 0.0026 0.0084
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0151 0.0761 0.076
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.005 0.0137
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0062 0.0277 0.1979
Echinococcus granulosus G protein coupled receptor 139 0.0104 0.0506 0.0505
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0506 0.0505
Brugia malayi neuropeptide F receptor 0.0104 0.0506 0.1692
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0561 0.2987 0.4418
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0065 0.0065
Schistosoma mansoni regulator of G protein signaling 0.002 0.005 0.005
Echinococcus granulosus tm gpcr rhodopsin 0.0104 0.0506 0.0505
Onchocerca volvulus 0.0104 0.0506 0.1478
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0065 0.1542
Echinococcus granulosus tyrosine kinase 0.0077 0.0362 0.036
Schistosoma mansoni transcription factor LCR-F1 0.0024 0.0073 0.0073
Echinococcus multilocularis nmda type glutamate receptor 0.0912 0.4897 0.4897
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0003 0.00000000034208
Loa Loa (eye worm) glutamate receptor 2 0.023 0.1191 0.1761
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0065 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0003 0.000000000037433
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0003 0.000000000037433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0104 0.0506 0.0748
Echinococcus granulosus sex peptide receptor 0.0104 0.0506 0.0505
Schistosoma mansoni neuropeptide receptor 0.0104 0.0506 0.0506
Schistosoma mansoni transient receptor potential channel 0.0023 0.0065 0.0065
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.005 0.0049
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.0506 0.0506
Plasmodium falciparum thioredoxin reductase 0.0024 0.0074 0.1894
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0023 0.0065 0.0065
Echinococcus granulosus peptide allatostatin:somatostatin 0.0104 0.0506 0.0505
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0073
Schistosoma mansoni glutamate receptor AMPA 0.023 0.1191 0.1191
Echinococcus multilocularis expressed protein 0.039 0.2059 0.2058
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.1887
Onchocerca volvulus 0.0104 0.0506 0.1478
Echinococcus multilocularis potassium voltage gated channel protein 0.0023 0.0065 0.0064
Schistosoma mansoni regulator of G protein signaling 0.002 0.005 0.005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.0506 0.0505

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.017 uM Compound was tested for its ability to inhibit calcium influx in human U937 cells ChEMBL. 9934474
IC50 (functional) = 0.017 uM Compound was tested for its ability to inhibit calcium influx in human U937 cells ChEMBL. 9934474
Inhibition (functional) 0 % Compound was tested for its ability to block antigen induced airway obstruction in guinea pig at dose 1 mg/kg at 2 hr; Not tested ChEMBL. 9934474
Ki (functional) = 0.004 uM Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes ChEMBL. 9934474
Ki (functional) = 0.004 uM Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes ChEMBL. 9934474

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 9934474

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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