Detailed information for compound 2110081

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 413.054 | Formula: C16H11N7O5S
  • H donors: 2 H acceptors: 5 LogP: 3.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 0
  • SMILES: [O-][N+](=O)c1ccc(cc1)c1[nH]n(c(=O)c1/N=N/c1cccc(c1)[N+](=O)[O-])C(=S)N
  • InChi: InChI=1S/C16H11N7O5S/c17-16(29)21-15(24)14(19-18-10-2-1-3-12(8-10)23(27)28)13(20-21)9-4-6-11(7-5-9)22(25)26/h1-8,20H,(H2,17,29)/b19-18+
  • InChiKey: HLHQJMGCPDOWLS-VHEBQXMUSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma No references
Homo sapiens l(3)mbt-like 1 (Drosophila) No references
Homo sapiens X-box binding protein 1 No references
Homo sapiens glucagon-like peptide 1 receptor No references
Candida albicans hypothetical protein No references
Homo sapiens chromobox homolog 1 No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble No references
Homo sapiens lamin A/C No references
Homo sapiens neuropeptide S receptor 1 No references
Homo sapiens survival of motor neuron 2, centromeric No references
Homo sapiens amyloid beta (A4) precursor protein-binding, family A, member 1 No references
Homo sapiens GNAS complex locus No references
Homo sapiens SMAD family member 2 No references
Influenza A virus Nonstructural protein 1 No references
Homo sapiens myeloid cell leukemia 1 No references
Homo sapiens eukaryotic translation initiation factor 4H No references
Homo sapiens adrenoceptor beta 2, surface No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Homo sapiens mitogen-activated protein kinase 1 No references
Homo sapiens multiple endocrine neoplasia I No references
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) No references
Homo sapiens nuclear factor, erythroid 2-like 2 No references
Mus musculus DNA-damage inducible transcript 3 No references
Homo sapiens geminin, DNA replication inhibitor No references
Homo sapiens parathyroid hormone 1 receptor No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni amyloid beta A4 protein related Get druggable targets OG5_130749 All targets in OG5_130749
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_127582 All targets in OG5_127582
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_127582 All targets in OG5_127582
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04531 amyloid beta (A4) precursor protein-binding, family A, member 1, putative Get druggable targets OG5_130749 All targets in OG5_130749
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus disco interacting protein 2 Get druggable targets OG5_127582 All targets in OG5_127582
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_127582 All targets in OG5_127582
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132232 All targets in OG5_132232
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to acyl-CoA ligase-like proteins in a variety of plant pathogens and to S. cerevisiae YOR093C Get druggable targets OG5_127582 All targets in OG5_127582
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) X11 protein Get druggable targets OG5_130749 All targets in OG5_130749
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus Eukaryotic translation initiation factor 4H Get druggable targets OG5_132232 All targets in OG5_132232
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Get druggable targets OG5_127582 All targets in OG5_127582
Mycobacterium ulcerans putative fatty-acid--CoA ligase Get druggable targets OG5_127582 All targets in OG5_127582
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus amyloid beta A4 protein Get druggable targets OG5_130749 All targets in OG5_130749
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_127582 All targets in OG5_127582
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis amyloid beta A4 protein Get druggable targets OG5_130749 All targets in OG5_130749
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_127582 All targets in OG5_127582
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_127582 All targets in OG5_127582
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130749 All targets in OG5_130749
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative Get druggable targets OG5_130749 All targets in OG5_130749
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Get druggable targets OG5_127582 All targets in OG5_127582
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Candida albicans similar to acyl-CoA ligase-like proteins in a variety of plant pathogens and to S. cerevisiae YOR093C Get druggable targets OG5_127582 All targets in OG5_127582
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni eukaryotic translation initiation factor 4h Get druggable targets OG5_132232 All targets in OG5_132232
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi hypothetical protein Get druggable targets OG5_130749 All targets in OG5_130749
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi RNA binding protein Get druggable targets OG5_132232 All targets in OG5_132232
Schistosoma mansoni eukaryotic translation initiation factor 4h Get druggable targets OG5_132232 All targets in OG5_132232
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis Eukaryotic translation initiation factor 4H Get druggable targets OG5_132232 All targets in OG5_132232
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134980 All targets in OG5_134980
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127582 All targets in OG5_127582
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis disco interacting protein 2 Get druggable targets OG5_127582 All targets in OG5_127582
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Get druggable targets OG5_127582 All targets in OG5_127582
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Disco-interacting protein 2 homolog Get druggable targets OG5_127582 All targets in OG5_127582
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni eukaryotic translation initiation factor 4h Get druggable targets OG5_132232 All targets in OG5_132232
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Eukaryotic translation initiation factor 4H, putative Get druggable targets OG5_132232 All targets in OG5_132232
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni disco-interacting protein 2 (dip2) Get druggable targets OG5_127582 All targets in OG5_127582
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127582 All targets in OG5_127582
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Echinococcus granulosus eukaryotic translation initiation factor 4b:4h eukaryotic translation initiation factor 4H 248 aa 217 aa 26.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 580 aa 544 aa 23.5 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0038 0.0421 0.085
Schistosoma mansoni lamin 0.0033 0.0319 0.0345
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0442 0.2673
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0778 0.1571
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.3879 0.3872
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0335 0.1997
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0072 0.0346
Echinococcus multilocularis Eukaryotic translation initiation factor 4H 0.0163 0.2704 0.2696
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.085 0.5243
Echinococcus multilocularis GPCR, family 2 0.0038 0.0421 0.041
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0587 0.7371
Loa Loa (eye worm) hypothetical protein 0.008 0.1182 0.2388
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.1554 0.1756
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0442 0.2673
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.085 0.5243
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0016 0.0018 0.0007
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0421 0.0817
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1264 0.2552
Loa Loa (eye worm) hypothetical protein 0.01 0.1554 0.3139
Treponema pallidum phosphoglycerate kinase 0.0103 0.1605 1
Echinococcus multilocularis disco interacting protein 2 0.0027 0.0224 0.0214
Onchocerca volvulus 0.0033 0.0319 0.3909
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0072 0.0346
Trypanosoma brucei phosphoglycerate kinase 0.0038 0.0414 0.2496
Onchocerca volvulus 0.0058 0.079 1
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Echinococcus multilocularis lamin dm0 0.0033 0.0319 0.0309
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.0295 0.0285
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0442 0.2673
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0924 0.1837
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0026 0.0192 0.0782
Loa Loa (eye worm) hypothetical protein 0.0058 0.0778 0.1571
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0072 0.0346
Trypanosoma brucei heat shock protein, putative 0.0039 0.0442 0.2673
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0072 0.0063
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0778 0.0869
Trypanosoma brucei protein kinase, putative 0.0062 0.085 0.5243
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0519 0.0508
Onchocerca volvulus 0.0058 0.0778 0.9847
Echinococcus multilocularis geminin 0.0205 0.347 0.3463
Schistosoma mansoni hypothetical protein 0.0038 0.0421 0.0461
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.4951 0.4946
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0778 0.0768
Trypanosoma brucei heat shock protein, putative 0.0039 0.0442 0.2673
Trypanosoma brucei phosphoglycerate kinase 0.0103 0.1605 1
Echinococcus granulosus dnaJ subfamily B 0.0494 0.8767 0.8765
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0026 0.0192 0.0782
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0224 0.0992
Brugia malayi hypothetical protein 0.0286 0.4951 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.085 0.4234
Schistosoma mansoni hypothetical protein 0.0205 0.347 0.3946
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0421 0.041
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0103 0.1605 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.079 0.0882
Schistosoma mansoni phosphoglycerate kinase 0.0103 0.1605 0.1814
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0295 0.1751
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0103 0.1605 1
Schistosoma mansoni apoptosis regulator bax 0.01 0.1554 0.1756
Mycobacterium ulcerans phosphoglycerate kinase 0.0103 0.1605 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0924 0.0914
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0421 0.041
Echinococcus granulosus chromobox protein 1 0.0084 0.1264 0.1254
Echinococcus multilocularis heat shock protein 0.0039 0.0442 0.0431
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0103 0.1605 1
Echinococcus multilocularis lamin 0.0033 0.0319 0.0309
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0224 0.0992
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0587 0.3586
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0442 0.2673
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0072 0.0111
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0224 0.0227
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0924 0.0914
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.1554 0.1545
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0421 0.041
Giardia lamblia Phosphoglycerate kinase 0.0103 0.1605 1
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.123 0.2457
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.085 0.5243
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0735 0.0724
Schistosoma mansoni endoplasmin 0.0039 0.0442 0.0485
Brugia malayi MH2 domain containing protein 0.0144 0.2363 0.4753
Chlamydia trachomatis phosphoglycerate kinase 0.0103 0.1605 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0735 0.1483
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Loa Loa (eye worm) hypothetical protein 0.0163 0.2704 0.5461
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0778 0.9847
Echinococcus granulosus phosphoglycerate kinase 1 0.0103 0.1605 0.1595
Echinococcus granulosus Eukaryotic translation initiation factor 4H 0.0163 0.2704 0.2696
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0442 0.2673
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0224 0.0992
Brugia malayi Endoplasmin precursor 0.0039 0.0442 0.086
Plasmodium falciparum phosphoglycerate kinase 0.0103 0.1605 1
Leishmania major phosphoglycerate kinase C, glycosomal 0.0103 0.1605 1
Schistosoma mansoni hypothetical protein 0.0043 0.0519 0.0573
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0027 0.0224 0.0992
Loa Loa (eye worm) X11 protein 0.0083 0.1242 0.2508
Schistosoma mansoni chromobox protein 0.0084 0.1264 0.1424
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0414 0.2496
Loa Loa (eye worm) hypothetical protein 0.0286 0.4951 1
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0778 0.0768
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0027 0.0224 0.0227
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0924 0.1036
Entamoeba histolytica hypothetical protein 0.0043 0.0519 0.3157
Schistosoma mansoni amyloid beta A4 protein related 0.0083 0.1242 0.1399
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0319 0.0645
Brugia malayi Disco-interacting protein 2 homolog 0.0027 0.0224 0.0419
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0442 0.0892
Echinococcus granulosus amyloid beta A4 protein 0.0083 0.1242 0.1232
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0442 0.2673
Brugia malayi isocitrate dehydrogenase 0.0019 0.0072 0.0111
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0442 0.2673
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0442 0.2673
Brugia malayi mbt repeat family protein 0.0058 0.0778 0.1541
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0038 0.0414 0.2496
Loa Loa (eye worm) hypothetical protein 0.012 0.1928 0.3893
Schistosoma mansoni heat shock protein 0.0039 0.0442 0.0485
Echinococcus multilocularis musashi 0.0033 0.0319 0.0309
Echinococcus multilocularis amyloid beta A4 protein 0.0083 0.1242 0.1232
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0735 0.0724
Schistosoma mansoni hypothetical protein 0.0038 0.0421 0.0461
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0442 0.2673
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0147 0.0817
Onchocerca volvulus 0.0033 0.0319 0.3909
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0442 0.1118
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0519 0.0573
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0072 0.0062
Schistosoma mansoni hypothetical protein 0.0058 0.079 0.0882
Loa Loa (eye worm) hypothetical protein 0.0027 0.0224 0.0453
Trypanosoma brucei phosphoglycerate kinase 0.0103 0.1605 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0735 0.0819
Brugia malayi chromobox protein homolog 3 0.0047 0.0587 0.1153
Echinococcus multilocularis heat shock protein 90 0.0031 0.0295 0.0285
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0103 0.1605 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.0319 0.0345
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0735 0.1453
Schistosoma mansoni hypothetical protein 0.01 0.1554 0.1756
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0414 0.2496
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Entamoeba histolytica phosphoglycerate kinase, putative 0.0103 0.1605 1
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0163 0.2704 0.307
Brugia malayi Phosphoglycerate kinase 0.0103 0.1605 0.3217
Schistosoma mansoni hypothetical protein 0.0038 0.0421 0.0461
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0442 0.2673
Trypanosoma brucei phosphoglycerate kinase, putative 0.0038 0.0414 0.2496
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0421 0.085
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0414 0.2496
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0027 0.0224 0.0236
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.085 0.084
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0224 0.0227
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0164 0.0922
Schistosoma mansoni endoplasmin 0.0039 0.0442 0.0485
Echinococcus multilocularis endoplasmin 0.0031 0.0295 0.0285
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.085 0.5243
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Echinococcus granulosus chromobox protein 1 0.0084 0.1264 0.1254
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0103 0.1605 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.085 0.5243
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0295 0.1751
Echinococcus granulosus GPCR family 2 0.0038 0.0421 0.041
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0016 0.0018 0.0007
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0043 0.0086
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0072 0.0062
Trypanosoma brucei heat shock protein, putative 0.0039 0.0442 0.2673
Brugia malayi hypothetical protein 0.0043 0.0519 0.1015
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1264 0.7851
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0519 0.0508
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.085 0.5243
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0735 0.0724
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0163 0.2704 0.307
Plasmodium vivax endoplasmin, putative 0.0039 0.0442 0.2673
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.0295 0.073
Mycobacterium ulcerans heat shock protein 90 0.0031 0.0295 0.0514
Schistosoma mansoni hypothetical protein 0.035 0.6134 0.6991
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0072 0.0062
Echinococcus granulosus heat shock protein 90 0.0039 0.0442 0.0431
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0072 0.0346
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0072 0.0346
Trypanosoma brucei heat shock protein, putative 0.0039 0.0442 0.2673
Brugia malayi MAP kinase sur-1 0.0062 0.085 0.1687
Schistosoma mansoni hypothetical protein 0.01 0.1554 0.1756
Brugia malayi Heterochromatin protein 1 0.0084 0.1264 0.2525
Loa Loa (eye worm) hypothetical protein 0.0082 0.123 0.2484
Onchocerca volvulus 0.0037 0.04 0.4955
Loa Loa (eye worm) heat shock protein 75 0.0016 0.0018 0.0036
Schistosoma mansoni hypothetical protein 0.0038 0.0421 0.0461
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0103 0.1605 1
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.1554 0.3139
Schistosoma mansoni phosphoglycerate kinase 0.0103 0.1605 0.1814
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0442 0.2673
Echinococcus multilocularis neuropeptide s receptor 0.0561 1 1
Entamoeba histolytica hypothetical protein 0.0043 0.0519 0.3157
Echinococcus granulosus heat shock protein 0.0039 0.0442 0.0431
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0778 0.0768
Brugia malayi mbt repeat family protein 0.0058 0.0778 0.1541
Plasmodium falciparum endoplasmin, putative 0.0024 0.0164 0.0922
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0442 0.2673
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0442 0.2673
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0072 0.0062
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.1928 0.3871
Echinococcus granulosus disco interacting protein 2 0.0027 0.0224 0.0214
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2363 0.4772
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.0295 0.1455
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0163 0.2704 0.307
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0295 0.1751
Echinococcus multilocularis X box binding protein 1 0.0348 0.6093 0.6089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0735 0.0819
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.1928 0.3871
Echinococcus multilocularis phosphoglycerate kinase 1 0.0103 0.1605 0.1595
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.4951 0.4946
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0421 0.041
Echinococcus granulosus lamin 0.0033 0.0319 0.0309
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.085 0.5243
Schistosoma mansoni hypothetical protein 0.0494 0.8767 1
Schistosoma mansoni heat shock protein 0.0039 0.0442 0.0485
Loa Loa (eye worm) hypothetical protein 0.0033 0.0319 0.0645
Brugia malayi intermediate filament protein 0.0033 0.0319 0.0612
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0072 0.0346
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.1554 0.1545
Brugia malayi RNA binding protein 0.0163 0.2704 0.5444
Echinococcus granulosus neuropeptide receptor A26 0.0561 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.085 0.5243
Trypanosoma brucei heat shock protein, putative 0.0039 0.0442 0.2673
Loa Loa (eye worm) hypothetical protein 0.0032 0.0309 0.0623
Schistosoma mansoni chromobox protein 0.0084 0.1264 0.1424
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0924 0.0914
Leishmania major phosphoglycerate kinase B, cytosolic 0.0103 0.1605 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0652 0.8221
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0778 0.0768
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.1554 0.1545
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.085 0.084
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.079 0.1565
Echinococcus granulosus X box binding protein 1 0.0348 0.6093 0.6089
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0778 0.0869
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1264 0.7851
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0072 0.0346
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0319 0.0612
Echinococcus multilocularis heat shock protein 90 0.0039 0.0442 0.0431
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.1554 0.1545
Schistosoma mansoni hypothetical protein 0.01 0.1554 0.1756
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0224 0.0992
Loa Loa (eye worm) hypothetical protein 0.0103 0.1605 0.3241
Brugia malayi hypothetical protein 0.008 0.1182 0.2361
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0442 0.2673
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2363 0.4772
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.085 0.0951
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.085 0.5243
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Loa Loa (eye worm) MBCTL1 0.0066 0.0924 0.1866
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.1928 0.3893
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.085 0.1716
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.085 0.5243
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0022
Schistosoma mansoni lamin 0.0033 0.0319 0.0345
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0027 0.0224 0.0227
Echinococcus granulosus geminin 0.0205 0.347 0.3463
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0103 0.1605 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0103 0.1605 1
Plasmodium vivax phosphoglycerate kinase, putative 0.0103 0.1605 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.1264 0.1254
Trypanosoma brucei heat shock protein, putative 0.0039 0.0442 0.2673
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0295 0.1751
Loa Loa (eye worm) hypothetical protein 0.0037 0.04 0.0808
Schistosoma mansoni hypothetical protein 0.0348 0.6093 0.6944
Loa Loa (eye worm) hypothetical protein 0.0027 0.0224 0.0453
Echinococcus multilocularis neuropeptide receptor A26 0.0561 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.085 0.084
Echinococcus granulosus endoplasmin 0.0031 0.0295 0.0285
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.085 0.084
Brugia malayi Phosphoglycerate kinase 0.0038 0.0414 0.0803
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.0295 0.1751
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0652 0.3999
Entamoeba histolytica hypothetical protein 0.0043 0.0519 0.3157
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.085 0.5243
Echinococcus granulosus intermediate filament protein 0.0033 0.0319 0.0309
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0072 0.0346
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.1554 0.3114
Echinococcus granulosus lamin dm0 0.0033 0.0319 0.0309
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0027 0.0224 0.0992
Loa Loa (eye worm) hypothetical protein 0.0047 0.0587 0.1185
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0735 0.0724
Entamoeba histolytica hypothetical protein 0.0043 0.0519 0.3157
Schistosoma mansoni hypothetical protein 0.0082 0.123 0.1386
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.3879 0.3872
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0587 0.3586
Plasmodium falciparum heat shock protein 90 0.0039 0.0442 0.2673
Loa Loa (eye worm) hypothetical protein 0.0066 0.0924 0.1866
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0421 0.0817
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0924 0.0914
Leishmania major heat shock protein 83-1 0.0039 0.0442 0.2673
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0103 0.1605 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0442 0.2673
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0735 0.0819
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0038 0.0414 0.2496
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0652 0.3999
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0072 0.0062
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0072 0.0062
Echinococcus multilocularis chromobox protein 1 0.0084 0.1264 0.1254
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0164 0.0922
Loa Loa (eye worm) endoplasmin 0.0039 0.0442 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0335 0.1997
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0038 0.0414 0.2496
Echinococcus granulosus heat shock protein 90 0.0031 0.0295 0.0285
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0224 0.0992
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0319 0.0645
Brugia malayi heat shock protein 90 0.0039 0.0442 0.086
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0072 0.0346
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.085 0.5243
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0074 0.1081 0.2156
Schistosoma mansoni hypothetical protein 0.0205 0.347 0.3946
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.8767 0.8765
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0778 0.0869
Trypanosoma brucei heat shock protein, putative 0.0039 0.0442 0.2673
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0072 0.0146
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0295 0.1751
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0043 0.0051

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) 15.48 uM PubChem BioAssay. Fluorescence polarization aasay to screen for inhibitors that compete for the binding of FadD28 to a bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) = 2.832 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
IC50 (functional) = 1.687350562 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1022 (Primary screen preceding this dose-response assay.)] ChEMBL. No reference
IC50 (binding) = 2.66 uM PUBCHEM_BIOASSAY: uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2014, AID2028, AID435011, AID435018, AID449744, AID449751, AID449752] ChEMBL. No reference
IC50 (binding) = 4 um PUBCHEM_BIOASSAY: Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay. Confirmatory Screen for inhibitors of association between Mint1-PDZ domains and N-type Ca2+ channel carboxyl-terminal peptide (NC peptide). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 4.4 uM PUBCHEM_BIOASSAY: CHOP dose-response primary assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
IC50 (functional) > 6.82 uM PUBCHEM_BIOASSAY: XBP1 DR counterscreen for CHOP. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
IC50 (binding) = 42.485 uM PUBCHEM_BIOASSAY: uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2012, AID2030, AID435011, AID435018, AID449744, AID449751, AID449752] ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4581 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 42.5615 uM PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 47.7548 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.0158 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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