Detailed information for compound 221922

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 280.344 | Formula: C16H12N2OS
  • H donors: 1 H acceptors: 2 LogP: 4.96 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)sc1n2cc(n1)c1cccc(c1)O
  • InChi: 1S/C16H12N2OS/c1-10-5-6-14-15(7-10)20-16-17-13(9-18(14)16)11-3-2-4-12(19)8-11/h2-9,19H,1H3
  • InChiKey: BWPDPSQXUUZBNX-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0161 0.2787 0.9348
Loa Loa (eye worm) voltage-gated potassium channel 0.0029 0.0123 0.0034
Entamoeba histolytica multidrug resistance protein, putative 0.017 0.2978 0.2977
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0033 0.0201 0.0115
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0029 0.0123 0.0125
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0508 0.9792 1
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0029 0.0123 0.0113
Leishmania major hypothetical protein, unknown function 0.0029 0.0123 0.0034
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0123 0.0125
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0508 0.9792 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0029 0.0123 0.0034
Echinococcus granulosus short transient receptor potential channel 6 0.0029 0.0123 0.0125
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0029 0.0123 0.0034
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0062 0.0784 0.0801
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0508 0.9792 1
Echinococcus multilocularis multidrug resistance protein 1 0.0353 0.6658 0.677
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0161 0.2787 0.2722
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0248 0.0163
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0029 0.0123 0.0125
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0295 0.0207
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0029 0.0123 0.0034
Entamoeba histolytica P-glycoprotein-2, putative 0.0508 0.9792 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0508 0.9792 1
Brugia malayi Cam kinase protein 1 0.0037 0.0295 0.0301
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0295 0.0211
Echinococcus multilocularis potassium voltage gated channel protein 0.0029 0.0123 0.0034
Echinococcus granulosus calcium activated potassium channel 0.0031 0.017 0.0174
Toxoplasma gondii transporter, cation channel family protein 0.0029 0.0123 0.0034
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.1244 0.1271
Schistosoma mansoni voltage-gated potassium channel 0.0283 0.5261 0.5373
Echinococcus multilocularis ryanodine receptor 44f 0.0029 0.0123 0.0034
Leishmania major protein kinase, putative 0.0035 0.0248 0.0163
Trypanosoma cruzi cAMP response protein 1, putative 0.0033 0.0201 0.0385
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0508 0.9792 1
Brugia malayi voltage-dependent calcium channel 0.0029 0.0123 0.0125
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0508 0.9792 1
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0161 0.2787 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0062 0.0784 0.0715
Plasmodium vivax ABC transporter B family member 7, putative 0.0161 0.2787 0.2722
Echinococcus granulosus voltage dependent calcium channel 0.0029 0.0123 0.0125
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0508 0.9792 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0029 0.0123 0.0034
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0033 0.0201 0.0198
Brugia malayi olfactory channel protein osm-9 0.0029 0.0123 0.0125
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0161 0.2787 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0161 0.2787 0.278
Giardia lamblia ABC transporter, putative 0.017 0.2978 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0029 0.0123 0.0125
Brugia malayi ABC transporter family protein 0.0161 0.2787 0.2846
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0033 0.0201 0.0115
Giardia lamblia Multidrug resistance-associated protein 1 0.0165 0.2865 0.9608
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0295 0.0301
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0029 0.0123 0.0125
Echinococcus granulosus potassium voltage gated channel protein 0.0029 0.0123 0.0125
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0035 0.0248 0.0163
Schistosoma mansoni hypothetical protein 0.0029 0.0123 0.0125
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0508 0.9792 1
Trypanosoma brucei Flagellar Member 6 0.0033 0.0201 0.0526
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0062 0.0784 0.0801
Onchocerca volvulus 0.0033 0.0201 0.0081
Schistosoma mansoni multidrug resistance protein 0.017 0.2978 0.3041
Plasmodium falciparum ABC transporter B family member 4, putative 0.0161 0.2787 0.2722
Leishmania major p-glycoprotein 0.0508 0.9792 1
Mycobacterium ulcerans transcriptional regulatory protein 0.0033 0.0201 0.0412
Loa Loa (eye worm) hypothetical protein 0.017 0.2978 0.2977
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0161 0.2787 0.9339
Echinococcus granulosus voltage gated potassium channel 0.0029 0.0123 0.0125
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0033 0.0201 0.0206
Schistosoma mansoni calcium-activated potassium channel 0.0029 0.0123 0.0125
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0402 0.108
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Plasmodium falciparum ABC transporter B family member 6, putative 0.0161 0.2787 0.2722
Schistosoma mansoni transient receptor potential channel 0.0029 0.0123 0.0125
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0029 0.0123 0.0258
Trypanosoma brucei glucose transporter, putative 0.0038 0.0304 0.0877
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0029 0.0123 0.0125
Echinococcus multilocularis potassium voltage gated channel protein 0.0029 0.0123 0.0034
Echinococcus granulosus shaker cognate 0.0029 0.0123 0.0125
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0502 0.9679 0.9884
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0033 0.0201 0.0385
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0295 0.0207
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0295 0.0211
Trichomonas vaginalis taga, putative 0.0508 0.9792 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0508 0.9792 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0029 0.0123 0.0125
Toxoplasma gondii protein kinase, putative 0.0345 0.6503 0.661
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0295 0.0207
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0508 0.9792 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.2787 0.278
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0508 0.9792 1
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0033 0.0201 0.0526
Echinococcus granulosus transient receptor potential gamma protein 0.0029 0.0123 0.0125
Plasmodium vivax proline--tRNA ligase, putative 0.0043 0.0402 0.0315
Loa Loa (eye worm) voltage-gated calcium channel 0.0029 0.0123 0.0034
Treponema pallidum catabolite gene activator (Crp) 0.0033 0.0201 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0508 0.9792 1
Treponema pallidum cyclic nucleotide binding protein 0.0033 0.0201 0.5
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0295 0.0207
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0029 0.0123 0.0034
Echinococcus multilocularis transient receptor potential cation channel 0.0029 0.0123 0.0034
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0037 0.0279 0.0285
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0295 0.0207
Trypanosoma brucei cAMP binding protein, putative 0.0033 0.0201 0.0526
Schistosoma mansoni ryanodine receptor related 0.0029 0.0123 0.0126
Loa Loa (eye worm) hypothetical protein 0.0228 0.414 0.4174
Trypanosoma brucei glucose transporter, putative 0.0038 0.0304 0.0877
Echinococcus multilocularis transient receptor potential cation channel 0.0029 0.0123 0.0034
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0029 0.0123 0.0125
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0295 0.0211
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0295 0.0844
Echinococcus granulosus patatin phospholipase domain containing protein 0.0033 0.0201 0.0206
Trypanosoma brucei multidrug resistance protein E 0.017 0.2978 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0029 0.0123 0.0125
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0033 0.0201 0.0112
Brugia malayi hypothetical protein 0.0029 0.0123 0.0125
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0232 0.4218 0.4308
Leishmania major glucose transporter, lmgt3 0.0038 0.0304 0.0221
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0033 0.0201 0.0206
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.2674 0.2731
Toxoplasma gondii hypothetical protein 0.0029 0.0123 0.0034
Leishmania major hypothetical protein, unknown function 0.0033 0.0201 0.0115
Trichomonas vaginalis abcb9, putative 0.0508 0.9792 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0161 0.2787 0.278
Schistosoma mansoni vesicular amine transporter 0.0029 0.0123 0.0125
Schistosoma mansoni multidrug resistance protein 0.0508 0.9792 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0508 0.9792 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0062 0.0784 0.0801
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0295 0.0301
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0508 0.9792 1
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0161 0.2787 0.278
Entamoeba histolytica P-glycoprotein-1 0.0508 0.9792 1
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0033 0.0201 0.0206
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0161 0.2787 1
Treponema pallidum catabolite gene activator 0.0033 0.0201 0.5
Echinococcus multilocularis voltage dependent calcium channel 0.0029 0.0123 0.0034
Echinococcus multilocularis transfer RNA-Gly 0.0029 0.0123 0.0034
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.009 0.0323
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0508 0.9792 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0052
Brugia malayi ABC transporter transmembrane region family protein 0.0161 0.2787 0.2846
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0062 0.0784 0.0801
Giardia lamblia Prolyl-tRNA synthetase 0.0037 0.0279 0.0655
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.009 0.0092
Leishmania major ABC-thiol transporter 0.017 0.2978 0.2977
Toxoplasma gondii facilitative glucose transporter GT1 0.0122 0.2004 0.1973
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0043 0.0402 0.0321
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0353 0.6658 0.6799
Echinococcus multilocularis conserved hypothetical protein 0.0029 0.0123 0.0034
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0161 0.2787 0.278
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0248 0.0254
Brugia malayi Sugar transporter family protein 0.0122 0.2004 0.2047
Echinococcus multilocularis voltage dependent calcium channel 0.0029 0.0123 0.0034
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0295 0.0207
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.2004 0.2047
Leishmania major protein kinase, putative 0.0037 0.0295 0.0211
Plasmodium falciparum hexose transporter 0.0122 0.2004 0.1932
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0033 0.0201 0.0206
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0161 0.2787 0.2841
Plasmodium falciparum multidrug resistance protein 1 0.0508 0.9792 0.979
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0029 0.0123 0.0113
Echinococcus multilocularis two pore calcium channel protein 2 0.0029 0.0123 0.0034
Schistosoma mansoni protein kinase 0.0037 0.0295 0.0301
Loa Loa (eye worm) hypothetical protein 0.0502 0.9679 0.9883
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0508 0.9792 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0508 0.9792 1
Brugia malayi ion channel NompC 0.0029 0.0123 0.0125
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0029 0.0123 0.0125
Toxoplasma gondii hypothetical protein 0.0029 0.0123 0.0034
Entamoeba histolytica ATP-binding cassette protein, putative 0.017 0.2978 0.2977
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0123 0.0125
Echinococcus granulosus two pore calcium channel protein 1 0.0029 0.0123 0.0125
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0115
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0029 0.0123 0.0126
Brugia malayi cation channel family protein 0.0029 0.0123 0.0125
Trichomonas vaginalis ABC transporter, putative 0.0508 0.9792 1
Entamoeba histolytica P-glycoprotein-5 0.0508 0.9792 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0029 0.0123 0.0125
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0508 0.9792 1
Schistosoma mansoni voltage-gated potassium channel 0.0062 0.0784 0.0801
Plasmodium falciparum ABC transporter B family member 3, putative 0.0161 0.2787 0.2722
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0029 0.0123 0.0125
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0123 0.0125
Echinococcus granulosus voltage dependent calcium channel 0.0029 0.0123 0.0125
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Echinococcus multilocularis shaker cognate 0.0029 0.0123 0.0034
Leishmania major glucose transporter, lmgt2 0.0038 0.0304 0.0221
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0084 0.1244 0.1189
Entamoeba histolytica P-glycoprotein 5, putative 0.0155 0.2674 0.2663
Trypanosoma brucei multidrug resistance-associated protein, putative 0.017 0.2978 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0029 0.0123 0.0034
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0029 0.0123 0.0034
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.009 0.0092
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0295 0.0211
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0304 0.0742
Echinococcus granulosus transient receptor potential cation channel 0.0029 0.0123 0.0125
Echinococcus granulosus multidrug resistance associated protein 1 0.017 0.2978 0.3041
Schistosoma mansoni 60S ribosomal protein L21 0.0052 0.0583 0.0595
Echinococcus granulosus voltage gated hydrogen channel 1 0.0029 0.0123 0.0125
Echinococcus granulosus transient receptor potential cation channel 0.0029 0.0123 0.0125
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0062 0.0784 0.0715
Trypanosoma brucei protein kinase A regulatory subunit 0.0033 0.0201 0.0526
Leishmania major protein kinase A regulatory subunit, putative 0.0033 0.0201 0.0115
Echinococcus granulosus transient receptor potential cation channel 0.0029 0.0123 0.0125
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0161 0.2787 0.278
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0295 0.0211
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0029 0.0123 0.0125
Echinococcus multilocularis General substrate transporter 0.0105 0.1658 0.1616
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0508 0.9792 1
Brugia malayi ABC transporter 0.0155 0.2674 0.2731
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0402 0.0321
Mycobacterium ulcerans regulatory protein 0.0033 0.0201 0.0412
Mycobacterium leprae Conserved hypothetical protein 0.0033 0.0201 0.0722
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0033 0.0201 0.0115
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0161 0.2787 0.5
Plasmodium vivax CDK-related protein kinase 6, putative 0.0518 1 1
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0029 0.0123 0.0125
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0201 0.0206
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0062 0.0784 0.0801
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0033 0.0201 0.0115
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0029 0.0123 0.0125
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Brugia malayi Egg laying defective protein 4 0.0035 0.0248 0.0254
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0037 0.0279 0.0285
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0279 0.0285
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0062 0.0784 0.0715
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0033 0.0201 0.0115
Echinococcus granulosus potassium voltage gated channel protein 0.0029 0.0123 0.0125
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Entamoeba histolytica P-glycoprotein 5, putative 0.0508 0.9792 1
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0033 0.0201 0.0206
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0033 0.0201 0.0206
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0029 0.0123 0.0125
Entamoeba histolytica ABC transporter, putative 0.017 0.2978 0.2977
Loa Loa (eye worm) ryanodine receptor 0.0029 0.0123 0.0034
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0029 0.0123 0.0125
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.009 0.0147
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0161 0.2787 0.2841
Brugia malayi P-glycoprotein-like protein 0.0161 0.2787 0.2846
Plasmodium falciparum multidrug resistance protein 2 0.0161 0.2787 0.2722
Trypanosoma cruzi hexose transporter 0.0038 0.0304 0.0742
Plasmodium falciparum ABC transporter B family member 5, putative 0.0161 0.2787 0.2722
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0508 0.9792 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0033 0.0201 0.0206
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0155 0.2674 0.2731
Entamoeba histolytica protein kinase, putative 0.0037 0.0295 0.0211
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0201 0.0198
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0155 0.2674 0.2731
Echinococcus multilocularis calcium activated potassium channel 0.0031 0.017 0.0082
Entamoeba histolytica P-glycoprotein 6, putative 0.0161 0.2787 0.278
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0029 0.0123 0.0125
Treponema pallidum cyclic nucleotide binding protein 0.0033 0.0201 0.5
Trypanosoma brucei glucose transporter, putative 0.0038 0.0304 0.0877
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0508 0.9792 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0029 0.0123 0.0034
Echinococcus multilocularis transient receptor potential cation channel 0.0029 0.0123 0.0034
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0295 0.0207
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0122 0.2004 0.1973
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0508 0.9792 1
Echinococcus multilocularis sodium leak channel non selective protein 0.0029 0.0123 0.0034
Plasmodium falciparum protein kinase 7 0.0345 0.6503 0.6471
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0161 0.2787 1
Trichomonas vaginalis ABC transporter, putative 0.0508 0.9792 1
Echinococcus granulosus hypothetical protein 0.0029 0.0123 0.0125
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0508 0.9792 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0033 0.0201 0.0081
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0161 0.2787 0.278
Plasmodium falciparum mitogen-activated protein kinase 2 0.0197 0.3522 0.3464
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0161 0.2787 0.2846
Mycobacterium ulcerans transmembrane transport protein 0.0033 0.0201 0.0412
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0084 0.1244 0.1271
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0033 0.0201 0.0206
Schistosoma mansoni transient receptor potential channel 0.0029 0.0123 0.0125
Loa Loa (eye worm) voltage-dependent calcium channel 0.0029 0.0123 0.0034
Schistosoma mansoni hypothetical protein 0.0033 0.0201 0.0206
Schistosoma mansoni protein kinase 0.0037 0.0295 0.0301
Brugia malayi cation channel family protein 0.0029 0.0123 0.0125
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0161 0.2787 0.2722
Schistosoma mansoni voltage-gated ion channel 0.0029 0.0123 0.0125
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0304 0.0311
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0295 0.0211
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0508 0.9792 1
Trypanosoma brucei glucose transporter, putative 0.0038 0.0304 0.0877
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0084 0.1244 0.1271
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0508 0.9792 1
Toxoplasma gondii hypothetical protein 0.0437 0.836 0.8524
Brugia malayi ABC transporter family protein 0.0508 0.9792 1
Schistosoma mansoni glucose transport protein 0.0122 0.2004 0.2047
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0508 0.9792 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0304 0.0877
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0033 0.0201 0.0115
Trichomonas vaginalis abcb9, putative 0.0508 0.9792 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0295 0.0301
Loa Loa (eye worm) hypothetical protein 0.0062 0.0784 0.0715
Echinococcus multilocularis transient receptor potential cation channel 0.0029 0.0123 0.0034
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.017 0.2978 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0029 0.0123 0.0034
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0248 0.0253
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0123 0.0125
Echinococcus multilocularis ATP binding cassette sub family B 0.0161 0.2787 0.278
Trypanosoma cruzi protein kinase A regulatory subunit 0.0033 0.0201 0.0385
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0295 0.0207
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0029 0.0123 0.0034
Echinococcus granulosus ATP binding cassette sub family B 0.0161 0.2787 0.2846
Loa Loa (eye worm) hypothetical protein 0.017 0.2978 0.2977
Trypanosoma brucei glucose transporter, putative 0.0038 0.0304 0.0877
Entamoeba histolytica P-glycoprotein 6, putative 0.0161 0.2787 0.278
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0029 0.0123 0.0125
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0295 0.0301
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.017 0.2978 0.2977
Echinococcus multilocularis multidrug resistance associated protein 7 0.017 0.2978 0.2977
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0037 0.0279 0.1002
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0304 0.0311
Echinococcus granulosus transient receptor potential cation channel 0.0029 0.0123 0.0125
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0508 0.9792 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.0035 0.0248 0.0254
Brugia malayi Transient-receptor-potential like protein 0.0029 0.0123 0.0125
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0033 0.0201 0.0115
Echinococcus granulosus voltage gated potassium channel 0.0084 0.1244 0.1271
Plasmodium vivax ABC transporter B family member 6, putative 0.0161 0.2787 0.2722
Giardia lamblia Multidrug resistance-associated protein 1 0.017 0.2978 1
Leishmania major protein kinase, putative 0.0035 0.0248 0.0163
Schistosoma mansoni multidrug resistance protein 0.0508 0.9792 1
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0161 0.2787 0.9339
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Brugia malayi ABC transporter transmembrane region family protein 0.0155 0.2674 0.2731
Loa Loa (eye worm) ABC transporter 0.0161 0.2787 0.278
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Echinococcus granulosus cGMP dependent protein kinase 1 0.0035 0.0248 0.0254
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0161 0.2787 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0295 0.0301
Trypanosoma cruzi cAMP binding protein, putative 0.0033 0.0201 0.0385
Echinococcus multilocularis ATP binding cassette sub family B 0.0161 0.2787 0.278
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0033 0.0201 0.0115
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0437 0.836 0.8524
Plasmodium vivax hexose transporter 0.0122 0.2004 0.1932
Loa Loa (eye worm) ABC transporter 0.0161 0.2787 0.278
Echinococcus granulosus ryanodine receptor 44f 0.0029 0.0123 0.0126
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.009 0.0092
Brugia malayi hypothetical protein 0.0161 0.2787 0.2846
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0033 0.0201 0.0206
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0508 0.9792 1
Trypanosoma brucei cAMP response protein 1, putative 0.0033 0.0201 0.0526
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0304 0.0877
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.2004 0.2047
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0029 0.0123 0.0125
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.021 0.3785 0.3866
Brugia malayi lysyl-tRNA synthetase 0.0027 0.009 0.0092
Brugia malayi ABC transporter family protein 0.0161 0.2787 0.2846
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.2004 0.2047
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0402 0.108
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0033 0.0201 0.0385
Echinococcus granulosus transient receptor potential cation channel 0.0029 0.0123 0.0125
Leishmania major hypothetical protein, conserved 0.0029 0.0123 0.0034
Schistosoma mansoni transient receptor potential channel 4 0.0029 0.0123 0.0125
Giardia lamblia MRP-like ABC transporter 0.017 0.2978 1
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0033 0.0201 0.0198
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0033 0.0201 0.0112
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0033 0.0201 0.0206
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0508 0.9792 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0037 0.0279 0.0285
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0062 0.0784 0.0801
Echinococcus multilocularis hyperpolarization activated cyclic 0.0062 0.0784 0.0715
Echinococcus multilocularis transient receptor potential cation channel 0.0029 0.0123 0.0034
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0029 0.0123 0.0125
Loa Loa (eye worm) ion channel NompC 0.0029 0.0123 0.0034
Loa Loa (eye worm) ABC transporter 0.0161 0.2787 0.278
Leishmania major glucose transporter, lmgt1 0.0038 0.0304 0.0221
Trypanosoma brucei p-glycoprotein 0.017 0.2978 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.2004 0.2047
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0029 0.0123 0.0034
Echinococcus multilocularis multidrug resistance protein 1 0.0508 0.9792 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0037 0.0279 0.0195
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0508 0.9792 1
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0248 0.0254
Echinococcus multilocularis ATP binding cassette sub family B 0.0502 0.9679 0.9883
Entamoeba histolytica P-glycoprotein-2 0.0508 0.9792 1
Echinococcus granulosus TRP transient receptor potential channel 0.0029 0.0123 0.0125
Echinococcus granulosus multidrug resistance protein 1 0.0508 0.9792 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0201 0.0206
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0062 0.0784 0.0715
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0029 0.0123 0.0125
Echinococcus granulosus multidrug resistance associated protein 7 0.017 0.2978 0.3041
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0037 0.0279 0.0195
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0261 0.4801 0.4856
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0161 0.2787 0.278
Entamoeba histolytica ATP-binding cassette protein, putative 0.017 0.2978 0.2977
Echinococcus granulosus hyperpolarization activated cyclic 0.0062 0.0784 0.0801
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0248 0.0254
Loa Loa (eye worm) hypothetical protein 0.0437 0.836 0.8524
Schistosoma mansoni voltage-gated potassium channel 0.0283 0.5261 0.5373
Loa Loa (eye worm) voltage-gated potassium channel 0.0029 0.0123 0.0034
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0261 0.4801 0.4903
Schistosoma mansoni smdr2 0.0508 0.9792 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0033 0.0201 0.0206
Echinococcus multilocularis potassium voltage gated channel protein 0.0029 0.0123 0.0034
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0295 0.0207
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0508 0.9792 1
Loa Loa (eye worm) hypothetical protein 0.0437 0.836 0.8524
Echinococcus granulosus multidrug resistance protein 1 0.0508 0.9792 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.2004 0.1973
Plasmodium falciparum ABC transporter B family member 7, putative 0.0161 0.2787 0.2722
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0033 0.0201 0.0526
Echinococcus granulosus potassium voltage gated channel protein 0.0029 0.0123 0.0125
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0161 0.2787 0.278
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0155 0.2674 0.2731
Loa Loa (eye worm) hypothetical protein 0.0084 0.1244 0.1189
Loa Loa (eye worm) AGC/PKG protein kinase 0.0035 0.0248 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0304 0.0311
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0033 0.0201 0.0112
Echinococcus granulosus sodium leak channel non selective protein 0.0029 0.0123 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0295 0.0301
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0029 0.0123 0.0125
Echinococcus multilocularis transient receptor potential gamma protein 0.0029 0.0123 0.0034
Loa Loa (eye worm) sugar transporter 0.0122 0.2004 0.1973
Mycobacterium ulcerans hypothetical protein 0.0033 0.0201 0.0412
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0295 0.0301
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0123 0.0125
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0304 0.0742
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0201 0.0385
Echinococcus granulosus ATP binding cassette sub family B 0.0155 0.2674 0.2731
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0161 0.2787 0.2846
Leishmania major glucose transporter/membrane transporter D2, putative 0.0038 0.0304 0.0221
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Loa Loa (eye worm) hypothetical protein 0.0155 0.2674 0.2663
Schistosoma mansoni multidrug resistance protein 0.017 0.2978 0.3041
Schistosoma mansoni multidrug resistance protein 0.017 0.2978 0.3041
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0033 0.0201 0.0115
Entamoeba histolytica ATP-binding cassette protein, putative 0.017 0.2978 0.2977
Plasmodium vivax ABC transporter B family member 3, putative 0.0161 0.2787 0.2722
Mycobacterium ulcerans hypothetical protein 0.0033 0.0201 0.0412
Plasmodium falciparum multidrug resistance-associated protein 2 0.0161 0.2787 0.2722
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0029 0.0123 0.0125
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0161 0.2787 0.5
Giardia lamblia Multidrug resistance-associated protein 1 0.017 0.2978 1
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0033 0.0201 0.0385
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Echinococcus multilocularis potassium large conductance calcium activated 0.0029 0.0123 0.0034
Leishmania major hypothetical protein, conserved 0.0033 0.0201 0.0115
Echinococcus multilocularis sodium channel protein 0.021 0.3785 0.3809
Leishmania major hypothetical protein, conserved 0.0033 0.0201 0.0115
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0304 0.0311
Trypanosoma brucei glucose transporter 2A 0.0038 0.0304 0.0877
Entamoeba histolytica ATP-binding cassette protein, putative 0.017 0.2978 0.2977
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0033 0.0201 0.0198
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0035 0.0248 0.0163
Mycobacterium tuberculosis Conserved protein 0.0033 0.0201 0.0198
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0029 0.0123 0.0125
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0295 0.0211
Trypanosoma cruzi Flagellar Member 6 0.0033 0.0201 0.0385
Trypanosoma brucei multidrug resistance-associated protein, putative 0.017 0.2978 1
Echinococcus granulosus short transient receptor potential channel 6 0.0029 0.0123 0.0125
Entamoeba histolytica P-glyco protein 6, putative 0.0508 0.9792 1
Trypanosoma brucei glucose transporter, putative 0.0038 0.0304 0.0877
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0123 0.0125
Schistosoma mansoni multidrug resistance protein 0.0155 0.2674 0.2731
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0123 0.0125
Loa Loa (eye worm) hypothetical protein 0.0508 0.9792 1
Echinococcus granulosus transient receptor potential cation channel 0.0029 0.0123 0.0125
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0295 0.0211
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0033 0.0201 0.0206
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0295 0.0211
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.2004 0.1973
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Trichomonas vaginalis ABC transporter, putative 0.0508 0.9792 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0161 0.2787 0.278
Echinococcus multilocularis ATP binding cassette sub family B 0.0161 0.2787 0.278
Schistosoma mansoni smdr1 0.0161 0.2787 0.2846
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.2004 0.1973
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0195
Schistosoma mansoni multidrug resistance protein 0.0161 0.2787 0.2846
Entamoeba histolytica P-glycoprotein-2 0.0508 0.9792 1
Entamoeba histolytica protein kinase, putative 0.0037 0.0295 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.2004 0.2047
Schistosoma mansoni glucose transport protein 0.0122 0.2004 0.2047
Schistosoma mansoni transient receptor potential channel 0.0029 0.0123 0.0125
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0261 0.4801 0.4903
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.017 0.2978 0.2977
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0402 0.0321
Echinococcus granulosus potassium voltage gated channel protein 0.0029 0.0123 0.0125
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0029 0.0123 0.0125
Echinococcus multilocularis two pore calcium channel protein 1 0.0029 0.0123 0.0034
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0508 0.9792 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0029 0.0123 0.0034
Plasmodium falciparum cGMP-dependent protein kinase 0.0035 0.0248 0.016
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0402 0.121
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0508 0.9792 1
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0155 0.2674 0.8947
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0037 0.0279 0.0285
Brugia malayi ABC transporter transmembrane region family protein 0.017 0.2978 0.3041
Leishmania major hypothetical protein, conserved 0.0033 0.0201 0.0115
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.017 0.2978 0.2977
Mycobacterium ulcerans hypothetical protein 0.0033 0.0201 0.0412
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0033 0.0201 0.0115
Schistosoma mansoni glucose transport protein 0.0122 0.2004 0.2047
Trypanosoma brucei glucose transporter, putative 0.0038 0.0304 0.0877
Echinococcus granulosus ATP binding cassette sub family B 0.0161 0.2787 0.2846
Leishmania major pentamidine resistance protein 1 0.017 0.2978 0.2977
Plasmodium vivax multidrug resistance protein 2, putative 0.0161 0.2787 0.2722
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0161 0.2787 0.9348
Brugia malayi multidrug resistance related protein 1 0.017 0.2978 0.3041
Trichomonas vaginalis ABC transporter, putative 0.0508 0.9792 1
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.0583 0.0595
Echinococcus multilocularis short transient receptor potential channel 6 0.0029 0.0123 0.0034
Brugia malayi ABC transporter family protein 0.0161 0.2787 0.2846
Leishmania major regulatory subunit of protein kinase a-like protein 0.0033 0.0201 0.0115
Schistosoma mansoni voltage-gated cation channel 0.0029 0.0123 0.0125
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0304 0.0742
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0033 0.0201 0.0206
Trypanosoma cruzi cAMP response protein 1 0.0033 0.0201 0.0385
Loa Loa (eye worm) hypothetical protein 0.0437 0.836 0.8524
Onchocerca volvulus 0.0033 0.0201 0.0081
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0123 0.0125
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0197 0.3522 0.3538
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0304 0.0311
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0033 0.0201 0.0206
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.1244 0.1271
Brugia malayi multidrug resistance protein 3 0.0508 0.9792 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0029 0.0123 0.0125
Trypanosoma brucei glucose transporter 1E 0.0038 0.0304 0.0877
Schistosoma mansoni multidrug resistance protein 0.0508 0.9792 1
Echinococcus granulosus multidrug resistance protein 1 0.0353 0.6658 0.6799
Echinococcus multilocularis multidrug resistance protein 1 0.0508 0.9792 1
Schistosoma mansoni hypothetical protein 0.0122 0.2004 0.2047
Entamoeba histolytica hypothetical protein 0.017 0.2978 0.2977
Loa Loa (eye worm) hypothetical protein 0.0508 0.9792 1
Echinococcus multilocularis 0.0161 0.2787 0.278
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0508 0.9792 1
Echinococcus multilocularis expressed conserved protein 0.0035 0.0248 0.0163
Giardia lamblia Hypothetical protein 0.0155 0.2674 0.8947
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0033 0.0201 0.0206
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0161 0.2787 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0295 0.0211
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0123 0.0125
Echinococcus granulosus cGMP dependent protein kinase 0.0035 0.0248 0.0254
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0033 0.0201 0.0206
Plasmodium vivax ABC transporter B family member 4, putative 0.0161 0.2787 0.2722
Echinococcus multilocularis multidrug resistance associated protein 1 0.017 0.2978 0.2977
Echinococcus multilocularis voltage gated potassium channel 0.0029 0.0123 0.0034
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0123 0.0125
Loa Loa (eye worm) multidrug resistance protein 3 0.0508 0.9792 1
Toxoplasma gondii transporter, cation channel family protein 0.0029 0.0123 0.0034
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.009 0.0092
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0029 0.0123 0.0125
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0029 0.0123 0.0125
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0115
Onchocerca volvulus 0.0508 0.9792 1
Toxoplasma gondii ABC transporter, putative 0.0161 0.2787 0.278
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0029 0.0123 0.0125
Loa Loa (eye worm) hypothetical protein 0.0165 0.2865 0.286
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0161 0.2787 0.2846
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0304 0.0311
Schistosoma mansoni two-pore calcium channel 0.0029 0.0123 0.0125
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0033 0.0201 0.0115
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0062 0.0784 0.0715
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0062 0.0784 0.0801
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0197 0.3522 0.3464
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0062 0.0784 0.0801
Trichomonas vaginalis abcb9, putative 0.0508 0.9792 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0029 0.0123 0.0125
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0033 0.0201 0.0206
Plasmodium falciparum multidrug resistance-associated protein 1 0.0161 0.2787 0.2722
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0029 0.0123 0.0034
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0304 0.0877
Schistosoma mansoni protein kinase 0.0037 0.0295 0.0301
Loa Loa (eye worm) calcium channel 0.0029 0.0123 0.0034
Leishmania major p-glycoprotein e 0.017 0.2978 0.2977
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0033 0.0201 0.0206
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.017 0.2978 0.2977
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Brugia malayi Cyclic-nucleotide gated cation channel 0.0062 0.0784 0.0801
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0304 0.0311
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0029 0.0123 0.0034
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0022 0.0023
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0161 0.2787 1
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0033 0.0201 0.0385
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0033 0.0201 0.0206
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0033 0.0201 0.0115
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.017 0.2978 0.2977
Leishmania major calcium channel protein, putative,ion transporter, putative 0.021 0.3785 0.3809
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0029 0.0123 0.0125
Echinococcus multilocularis voltage gated potassium channel 0.0084 0.1244 0.1189
Trypanosoma brucei glucose transporter, putative 0.0038 0.0304 0.0877
Echinococcus granulosus General substrate transporter 0.0105 0.1658 0.1693
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0232 0.4218 0.4308
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0033 0.0201 0.0206
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0261 0.4801 0.4856
Trypanosoma cruzi multidrug resistance protein E, putative 0.017 0.2978 1
Echinococcus granulosus sodium channel protein 0.021 0.3785 0.3866
Toxoplasma gondii ABC transporter family protein 0.0161 0.2787 0.278
Echinococcus multilocularis ATP binding cassette sub family B 0.0161 0.2787 0.278
Echinococcus granulosus multidrug resistance protein 1 0.0353 0.6658 0.6799
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0029 0.0123 0.0125
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0062 0.0784 0.0715
Leishmania major cyclic nucleotide-binding protein-like protein 0.0033 0.0201 0.0115
Echinococcus multilocularis transient receptor potential cation channel 0.0029 0.0123 0.0034
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0155 0.2674 0.2731
Schistosoma mansoni voltage-dependent calcium channel 0.0029 0.0123 0.0125
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0279 0.0285
Plasmodium falciparum proline--tRNA ligase 0.0043 0.0402 0.0315
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Echinococcus granulosus potassium voltage gated channel protein 0.0029 0.0123 0.0125
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0029 0.0123 0.0034
Echinococcus granulosus two pore calcium channel protein 2 0.0029 0.0123 0.0125
Toxoplasma gondii transporter, cation channel family protein 0.0029 0.0123 0.0034
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0029 0.0123 0.0125
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0029 0.0123 0.0034
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0035 0.0248 0.0163
Mycobacterium ulcerans hypothetical protein 0.0033 0.0201 0.0412
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0123 0.0125
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.017 0.2978 1
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0038 0.0314 0.0314
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0033 0.0201 0.0115
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0508 0.9792 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0508 0.9792 0.979
Echinococcus granulosus multidrug resistance protein 1 0.0508 0.9792 1
Brugia malayi ABC transporter 0.0161 0.2787 0.2846
Brugia malayi N-terminal motif family protein 0.0033 0.0201 0.0206
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0508 0.9792 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0155 0.2674 0.2663
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0201 0.0206
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0029 0.0123 0.0125
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0029 0.0123 0.0258
Schistosoma mansoni multidrug resistance protein 0.017 0.2978 0.3041
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0033 0.0201 0.0206
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0123 0.0125
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0007 0.0026
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.017 0.2978 0.2977
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0062 0.0784 0.0801
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0062 0.0784 0.0801
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0034
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0062 0.0784 0.0801
Echinococcus granulosus potassium large conductance calcium activated 0.0029 0.0123 0.0125
Plasmodium vivax ABC transporter B family member 5, putative 0.0161 0.2787 0.2722
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0201 0.0198
Echinococcus granulosus hyperpolarization activated cyclic 0.0062 0.0784 0.0801
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0508 0.9792 1

Activities

Activity type Activity value Assay description Source Reference
Increase in ear thickness (functional) = 3.8 1/100mm Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 400 mg/kg ChEMBL. 3512827
Increase in ear thickness (functional) = 3.8 1/100mm Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 400 mg/kg ChEMBL. 3512827
Increase in ear thickness (functional) = 4.5 1/100mm Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 50 mg/kg ChEMBL. 3512827
Increase in ear thickness (functional) = 4.5 1/100mm Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 50 mg/kg ChEMBL. 3512827
Inhibition (functional) = -12.5 % Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 50 mg/kg ChEMBL. 3512827
Inhibition (functional) = -12.5 % Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 50 mg/kg ChEMBL. 3512827
Inhibition (functional) = 5 % Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 400 mg/kg ChEMBL. 3512827
Inhibition (functional) = 5 % Significant suppressive activity of delayed type hypertensitivity(DTH) with out inhibition of humoral immunity in mice by oral administration at dose of 400 mg/kg ChEMBL. 3512827

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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