Detailed information for compound 251160

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 878.005 | Formula: C46H56FN11O6
  • H donors: 8 H acceptors: 6 LogP: 3.47 Rotable bonds: 27
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC(CC(C(=O)NC(C(=O)N)CCCN=C(N)N)NC(=O)C(NC(=O)C(N(C(=O)c1ccc(cc1)c1ccccc1)C(=O)C)Cc1ccc(cc1)F)Cc1ccc(cc1)NC(=N)N)C
  • InChi: 1S/C46H56FN11O6/c1-27(2)24-37(41(61)55-36(40(48)60)10-7-23-53-45(49)50)56-42(62)38(25-29-13-21-35(22-14-29)54-46(51)52)57-43(63)39(26-30-11-19-34(47)20-12-30)58(28(3)59)44(64)33-17-15-32(16-18-33)31-8-5-4-6-9-31/h4-6,8-9,11-22,27,36-39H,7,10,23-26H2,1-3H3,(H2,48,60)(H,55,61)(H,56,62)(H,57,63)(H4,49,50,53)(H4,51,52,54)
  • InChiKey: JBPXQTDVWSOEKW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0039 0.0039
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.0416 0.0416
Giardia lamblia DINP protein human, muc B family 0.0041 0.0129 0.0294
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0041 0.0041
Echinococcus multilocularis 6 phosphofructokinase 0.0232 0.1011 0.1011
Loa Loa (eye worm) 6-phosphofructokinase 0.0232 0.1011 0.3393
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0096 0.0381 0.7084
Schistosoma mansoni intermediate filament proteins 0.0058 0.0209 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.007 0.0645
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0076
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0209 0.0702
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0023 0.0171
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0207 0.0897 0.433
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0085 0.0797
Echinococcus granulosus phd:f box containing protein 0.0018 0.0023 0.0023
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0266 0.0891
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0209 0.0702
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0102 0.0413 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0039 0.013
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0047 0.0156
Leishmania major hypothetical protein, conserved 0.0018 0.0023 0.0171
Echinococcus granulosus geminin 0.0173 0.074 0.074
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0223 0.0748
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0381 0.0381
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0041 0.0041
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0164 0.3051
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0229 0.0546
Echinococcus multilocularis expressed protein 0.0425 0.1904 0.1904
Mycobacterium tuberculosis Probable dehydrogenase 0.0207 0.0897 0.433
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0047 0.0047
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0039 0.0039
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0047 0.0156
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0018
Schistosoma mansoni cpg binding protein 0.0061 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.013
Brugia malayi Pre-SET motif family protein 0.0659 0.2981 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.009
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0287 0.0964
Entamoeba histolytica hypothetical protein 0.011 0.0447 0.1064
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.013
Schistosoma mansoni DNA helicase recq5 0.0019 0.0027 0.0027
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.0416 0.4085
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0287 0.0964
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0137
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0085 0.0085
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0209 0.0702
Echinococcus granulosus thioredoxin glutathione reductase 0.0091 0.0362 0.0362
Brugia malayi Pre-SET motif family protein 0.0096 0.0381 0.128
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0129 0.0432
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.008 0.0268
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0023 0.0171
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0085 0.0797
Loa Loa (eye worm) phosphofructokinase 0.0232 0.1011 0.3393
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0039 0.013
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0027 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0153
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0039 0.0093
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.0416 0.4085
Loa Loa (eye worm) hypothetical protein 0.0036 0.0108 0.0361
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0797
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0923 0.4201 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0039 0.013
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.005 0.0449
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0085 0.0797
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0797
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0067 0.0249 0.0249
Echinococcus multilocularis Chromobox protein 3 0.0013 0.000000026967 0.000000026967
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0039 0.0039
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0052 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0041 0.0097
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0039 0.0039
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0047 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0381 0.0381
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0156 0.037
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0023 0.0023
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0023 0.0023
Trypanosoma brucei cytochrome P450, putative 0.003 0.008 0.0741
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0023 0.0023
Plasmodium falciparum thioredoxin reductase 0.0032 0.0085 0.1911
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.008 0.0268
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0129 0.0306
Leishmania major cytochrome p450-like protein 0.003 0.008 0.0741
Brugia malayi SET domain containing protein 0.0018 0.0022 0.0074
Leishmania major hypothetical protein, conserved 0.0026 0.0059 0.0535
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.013 0.0538 0.252
Loa Loa (eye worm) hypothetical protein 0.0085 0.0333 0.1116
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0538 0.252
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0052 0.0468
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0129 0.0453
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0064 0.0153
Brugia malayi CHD4 protein 0.0016 0.0016 0.0054
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0005 0.0005
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.0416 0.4085
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0039 0.013
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0371 0.0883
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0141 0.0141
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0381 0.0381
Brugia malayi steroid hormone receptor 0.0021 0.0039 0.013
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0088
Brugia malayi glutaminase DH11.1 0.0312 0.1378 0.4624
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.001
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0059 0.1097
Mycobacterium ulcerans glutaminase 0.0312 0.1378 0.6756
Trypanosoma brucei polo-like protein kinase 0.0093 0.0371 0.3636
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0371 0.1245
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0041 0.0137
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0091 0.036 0.1618
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0094 0.0315
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0371 0.3636
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0447 0.1064
Echinococcus multilocularis lamin 0.0058 0.0209 0.0209
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0153
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0039 0.0039
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0125 0.2791
Schistosoma mansoni ap endonuclease 0.0021 0.0039 0.0039
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0287 0.0287
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0059 0.0535
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0129 0.1227
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0063 0.0229 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0039 0.0039
Trypanosoma brucei unspecified product 0.0041 0.0129 0.1227
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0041 0.0097
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0014 0.0005 0.0018
Toxoplasma gondii exonuclease III APE 0.0021 0.0039 0.0723
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0085 0.1911
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0129 0.0432
Brugia malayi hypothetical protein 0.0026 0.0059 0.0198
Echinococcus granulosus intermediate filament protein 0.0058 0.0209 0.0209
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0041 0.0041
Trypanosoma cruzi trypanothione reductase, putative 0.0091 0.036 0.3523
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0333 0.0333
Toxoplasma gondii phosphofructokinase PFKII 0.0063 0.0229 0.4261
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.005 0.0058
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0129 0.1227
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0371 0.0883
Brugia malayi PXA domain containing protein 0.0022 0.0041 0.0137
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.007 0.007
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.005 0.2478
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0039 0.013
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0063 0.0229 0.4261
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0047 0.0047
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0085 0.0085
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0014 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.001
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0181 0.0776 0.0776
Trypanosoma brucei unspecified product 0.0028 0.007 0.0645
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0109 0.0441 0.0441
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0232 0.1011 0.4905
Mycobacterium ulcerans 6-phosphofructokinase 0.0232 0.1011 0.4905
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0041 0.0041
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0164 0.0164
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0023 0.0076
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.0416 0.098
Schistosoma mansoni cpg binding protein 0.0065 0.0239 0.0239
Brugia malayi beta-NAC-like protein 0.011 0.0447 0.15
Onchocerca volvulus 0.0115 0.0473 0.1291
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0039 0.0039
Echinococcus granulosus 6 phosphofructokinase 0.0232 0.1011 0.1011
Brugia malayi Cytochrome P450 family protein 0.003 0.008 0.0268
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.007 0.007
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0063 0.0229 0.0534
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0129 0.0129
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0129 0.0129
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0041 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0165 0.0703 0.0703
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0039 0.0871
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0229 0.0546
Schistosoma mansoni 6-phosphofructokinase 0.0232 0.1011 0.1011
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0129 0.0129
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0039 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0371 0.0371
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0538 0.252
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0047 0.0047
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0333 0.1116
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0041 0.0097
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0023 0.0076
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0014 0.0005 0.0098
Loa Loa (eye worm) CYP4Cod1 0.003 0.008 0.0268
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0023 0.0418
Brugia malayi Cytochrome P450 family protein 0.003 0.008 0.0268
Plasmodium vivax glutathione reductase, putative 0.0091 0.036 0.8045
Echinococcus multilocularis thioredoxin glutathione reductase 0.0091 0.0362 0.0362
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0014 0.0005 0.0013
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0129 0.0306
Brugia malayi ecdysteroid receptor 0.0021 0.0039 0.013
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0085 0.1911
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0085 0.1587
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0041 0.0041
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0041 0.0041
Echinococcus multilocularis dnaJ subfamily B 0.0466 0.2092 0.2092
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0039 0.013
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0371 0.0883
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0039 0.0039
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0041 0.0041
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0041 0.0041
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0041 0.0137
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0063 0.0229 0.5131
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0039 0.0335
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0153
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0207 0.0897 0.433
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0041 0.0041
Brugia malayi MAP kinase sur-1 0.0103 0.0416 0.1396
Plasmodium vivax 6-phosphofructokinase, putative 0.0063 0.0229 0.5131
Mycobacterium ulcerans aldehyde dehydrogenase 0.013 0.0538 0.252
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0063 0.0229 0.5131
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0129 0.0453
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0287 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.001
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0027 0.0027
Toxoplasma gondii 6-phosphofructokinase 0.0063 0.0229 0.4261
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.005 0.1129
Leishmania major trypanothione reductase 0.0091 0.036 0.3523
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0137
Giardia lamblia Kinase, PLK 0.0093 0.0371 0.0872
Echinococcus granulosus dnaJ subfamily B 0.0466 0.2092 0.2092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0797
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0041 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0034 0.0082
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0041 0.0041
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0085 0.1587
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Brugia malayi glutathione reductase 0.0091 0.036 0.1207
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0023 0.0023
Onchocerca volvulus 0.0115 0.0473 0.1291
Echinococcus multilocularis bloom syndrome protein 0.0046 0.015 0.015
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.0681 0.0681
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0023 0.0023
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0039 0.0039
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.0106 0.0106
Loa Loa (eye worm) 6-phosphofructokinase 0.0232 0.1011 0.3393
Brugia malayi intermediate filament protein 0.0058 0.0209 0.0702
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0014 0.0005 0.0005
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0047 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.0416 0.773
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0041 0.0097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0039 0.013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0381 0.0381
Brugia malayi jmjC domain containing protein 0.0071 0.0266 0.0891
Entamoeba histolytica phosphofructokinase, putative 0.0232 0.1011 0.2408
Brugia malayi nuclear hormone receptor 0.0021 0.0039 0.013
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0416 0.0991
Brugia malayi Thioredoxin reductase 0.0091 0.036 0.1207
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.007 0.0645
Leishmania major basic transcription factor 3a, putative 0.011 0.0447 0.4392
Trypanosoma brucei unspecified product 0.0028 0.007 0.0645
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0023 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0039 0.013
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0287 0.0287
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0416 0.0416
Echinococcus granulosus lamin 0.0058 0.0209 0.0209
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0115 0.0473 0.1586
Onchocerca volvulus 0.0058 0.0209 0.0507
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.0416 0.0416
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0041 0.0041
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0023 0.0504
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0229 0.0546
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.013
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0027 0.06
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0041 0.0041
Entamoeba histolytica hypothetical protein 0.0022 0.0041 0.0097
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0102 0.0413 0.0413
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0129 0.0129
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.005 0.0449
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0923 0.4201 1
Mycobacterium tuberculosis Probable reductase 0.0207 0.0897 0.433
Echinococcus granulosus Chromobox protein 3 0.0013 0.000000026967 0.000000026967
Toxoplasma gondii aldehyde dehydrogenase 0.013 0.0538 1
Brugia malayi POT family protein 0.0083 0.0325 0.1091
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0082 0.1839
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0041 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0153
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0137
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0044 0.0044
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0039 0.013
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0041 0.0041
Brugia malayi nuclear receptor NHR-88 0.0021 0.0039 0.013
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0039 0.013
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.005 0.1129
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0538 0.0538
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.013 0.0538 0.0538
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.003 0.0071
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.0218
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0129 0.0453
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0067 0.0249 0.0249
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0085 0.0203
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0129 0.0453
Schistosoma mansoni cpg binding protein 0.0065 0.0239 0.0239
Loa Loa (eye worm) RecQ helicase 0.0046 0.015 0.0504
Trichomonas vaginalis phosphofructokinase, putative 0.0232 0.1011 0.2408
Leishmania major ATP-dependent phosphofructokinase 0.0232 0.1011 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0204 0.0685
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0231 0.1004 0.4869
Echinococcus granulosus Solute carrier family 22 5 0.1059 0.4828 0.4828
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0287 0.2803
Loa Loa (eye worm) glutaminase 0.0312 0.1378 0.4624
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0027 0.009
Schistosoma mansoni kinase 0.0048 0.0161 0.0161
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0005 0.0013
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0232 0.1011 0.2336
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0232 0.1011 1
Plasmodium falciparum thioredoxin reductase 0.0091 0.036 0.8045
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0085 0.0797
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0027 0.0498
Toxoplasma gondii NAC domain-containing protein 0.011 0.0447 0.8304
Brugia malayi M-phase phosphoprotein, mpp8 0.0115 0.0473 0.1586
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0416 0.4085
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0027 0.009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0041 0.0137
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0039 0.0039
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.005 0.0058
Trichomonas vaginalis dullard protein, putative 0.0014 0.0005 0.0013
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.0416 0.4085
Trichomonas vaginalis helicase, putative 0.0014 0.0004 0.001
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0041 0.0041
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0039 0.0039
Echinococcus granulosus CTD small phosphatase protein like 0.0014 0.0005 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0231 0.1004 0.4869
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0371 0.1245
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0181 0.0776 0.7664
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0141 0.0141
Entamoeba histolytica hypothetical protein 0.0022 0.0041 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.001
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0005 0.0013
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0019 0.0026 0.0026
Plasmodium vivax thioredoxin reductase, putative 0.0091 0.036 0.8045
Onchocerca volvulus 0.0085 0.0333 0.0875
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0064 0.0153
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.013 0.0538 0.53
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0039 0.013
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0229 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0039 0.013
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0129 0.1227
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0039 0.0039
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0014 0.0005 0.0118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0797
Giardia lamblia Fructose-bisphosphate aldolase 0.0923 0.4201 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0027 0.0498
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0026 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0371 0.0883
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0146 0.0334
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0039 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0039 0.0039
Loa Loa (eye worm) glutaminase 2 0.0312 0.1378 0.4624
Schistosoma mansoni lamin 0.0058 0.0209 0.0209
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0085 1
Entamoeba histolytica phosphofructokinase, putative 0.0232 0.1011 0.2408
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0023 0.0418
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.005 0.0058
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0039 0.0039
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0041 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0041 0.0137
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0333 0.0333
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.0416 0.4085
Echinococcus granulosus cpg binding protein 0.0065 0.0239 0.0239
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0026 0.0026
Brugia malayi hypothetical protein 0.0139 0.058 0.1947
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0041 0.0041
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0059 0.1321
Loa Loa (eye worm) hypothetical protein 0.0096 0.0381 0.128
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0085 0.0797
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0287 0.0684
Brugia malayi jmjC domain containing protein 0.0018 0.0023 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0039 0.013
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0287 0.2803
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.013
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0041 0.0041
Onchocerca volvulus 0.0749 0.34 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.001
Echinococcus granulosus expressed protein 0.0425 0.1904 0.1904
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0181 0.0776 0.0776
Echinococcus granulosus bloom syndrome protein 0.0046 0.015 0.015
Trichomonas vaginalis DNA helicase recq1, putative 0.0046 0.015 0.0358
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0023 0.0171
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0041 0.0097
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0039 0.0335
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0026 0.0026
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0102 0.0413 0.0413
Brugia malayi jmjC domain containing protein 0.0018 0.0023 0.0076
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0797
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0231 0.1004 0.4839
Brugia malayi hypothetical protein 0.0022 0.0041 0.0137
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0085 1
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0129 0.1227
Toxoplasma gondii histone lysine methyltransferase SET1 0.0124 0.0511 0.9489
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0447 0.1064
Schistosoma mansoni hypothetical protein 0.0466 0.2092 0.2092
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.015 0.0358
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0207 0.0897 0.433
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0047 0.0047
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0451 0.2021 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0371 0.0371
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0039 0.0039
Trichomonas vaginalis dullard protein, putative 0.0014 0.0005 0.0013
Schistosoma mansoni DNA helicase recq1 0.0019 0.0027 0.0027
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0085 0.0235
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0085 0.0797
Loa Loa (eye worm) hypothetical protein 0.0041 0.0129 0.0432
Entamoeba histolytica hypothetical protein 0.0024 0.005 0.012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0039 0.0039
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0039 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0416 0.0991
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0039 0.0039
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0923 0.4201 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0041 0.0041
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0047 0.0156
Brugia malayi jmjC domain containing protein 0.0067 0.0249 0.0837
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0923 0.4201 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0041 0.0137
Schistosoma mansoni glutaminase 0.0312 0.1378 0.1378
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0052 0.0125
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0016 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0059 0.1321
Schistosoma mansoni hypothetical protein 0.0014 0.0004 0.0004
Plasmodium falciparum glutathione reductase 0.0032 0.0085 0.1911
Schistosoma mansoni DNA polymerase eta 0.0041 0.0129 0.0129
Trypanosoma cruzi transcription factor btf3, putative 0.011 0.0447 0.4392
Trichomonas vaginalis phosphofructokinase, putative 0.0232 0.1011 0.2408
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0023 0.0023
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0052 0.0468
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0034 0.0082
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0039 0.0039
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0371 0.0883
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0039 0.0039
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0047 0.0047
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0416 0.4085
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0232 0.1011 0.4875
Mycobacterium tuberculosis Probable oxidoreductase 0.0231 0.1004 0.4869
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0039 0.0039
Leishmania major DNA polymerase eta, putative 0.0041 0.0129 0.1227
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0096 0.0381 0.0381
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0371 0.3636
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0084 0.0283
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0039 0.013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.0218
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0085 0.1911
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.005 0.0937
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0797
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.007 0.0645
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0063 0.0229 0.0546
Echinococcus multilocularis 0.0014 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0039 0.013
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0044 0.0146
Onchocerca volvulus 0.0058 0.0209 0.0507
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0923 0.4201 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.005 0.0937
Echinococcus multilocularis geminin 0.0173 0.074 0.074
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0039 0.0131
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0039 0.0039
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.0005 0.0118
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0923 0.4201 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.0416 0.1396
Brugia malayi jmjC domain containing protein 0.0018 0.0023 0.0076
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0041 0.0097
Loa Loa (eye worm) glutathione reductase 0.0091 0.036 0.1207
Echinococcus granulosus dna polymerase eta 0.0041 0.0129 0.0129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0381 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0039 0.013
Toxoplasma gondii thioredoxin reductase 0.0091 0.036 0.668
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0229 0.0546
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0023 0.0023
Plasmodium vivax 6-phosphofructokinase, putative 0.0063 0.0229 0.5131
Brugia malayi jmjC domain containing protein 0.0018 0.0023 0.0076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0416 0.0991
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.001
Plasmodium vivax basic transcription factor 3b, putative 0.011 0.0447 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0039 0.0335
Echinococcus multilocularis lamin dm0 0.0058 0.0209 0.0209
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0027 0.009
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0039 0.0093
Brugia malayi hypothetical protein 0.0115 0.0473 0.1586
Schistosoma mansoni hypothetical protein 0.0173 0.074 0.074
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0371 0.0371
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0181 0.0776 0.3719
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0085 0.0235
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0164 0.0391
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0085 0.0085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0923 0.4201 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0451 0.2021 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0169 0.072 0.2415
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0181 0.0776 0.3719
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Plasmodium falciparum glutathione reductase 0.0091 0.036 0.8045
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0085 0.0235
Echinococcus multilocularis transcription factor btf3 0.011 0.0447 0.0447
Brugia malayi phosphofructokinase 0.0232 0.1011 0.3393
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0165 0.0703 0.0703
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0052 0.0468
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0371 0.3636
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0102 0.0413 0.0413
Brugia malayi acetyltransferase, GNAT family protein 0.0165 0.0703 0.2357
Trichomonas vaginalis dullard protein, putative 0.0014 0.0005 0.0013
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0129 0.1227
Schistosoma mansoni hypothetical protein 0.0059 0.0212 0.0212
Plasmodium falciparum basic transcription factor 3b, putative 0.011 0.0447 1
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0041 0.0041
Loa Loa (eye worm) acetyltransferase 0.0165 0.0703 0.2357
Treponema pallidum fructose-bisphosphate aldolase 0.0923 0.4201 1
Trichomonas vaginalis set domain proteins, putative 0.0749 0.34 0.8094
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.013 0.0538 0.0538
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0023 0.0023
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0173 0.074 0.074
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0371 0.0883
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.0005 0.0118
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0039 0.0039
Echinococcus granulosus transcription factor btf3 0.011 0.0447 0.0447
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0042 0.0142
Loa Loa (eye worm) thioredoxin reductase 0.0091 0.036 0.1207
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0146 0.0347
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0063 0.0229 0.0546
Trichomonas vaginalis phosphofructokinase, putative 0.0232 0.1011 0.2408
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0287 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0797
Trypanosoma brucei protein kinase, putative 0.0103 0.0416 0.4085
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0232 0.1011 1
Trypanosoma brucei transcription factor BTF3, putative 0.011 0.0447 0.4392
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0129 0.1227
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0063 0.0229 0.0458
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0371 0.0883
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0041 0.0137
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0797
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0371 0.0883
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0039 0.013
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0447 0.1064
Entamoeba histolytica phosphofructokinase, putative 0.0232 0.1011 0.2408
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0181 0.0776 0.2604
Plasmodium vivax SET domain protein, putative 0.0096 0.0381 0.8531
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0005 0.0013
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0287 0.2803
Brugia malayi CXXC zinc finger family protein 0.0061 0.0223 0.0748
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0207 0.0897 0.433
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0004 0.001
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0416 0.0991
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0041 0.0137
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0266 0.0266
Schistosoma mansoni ap endonuclease 0.0021 0.0039 0.0039
Trichomonas vaginalis phosphofructokinase, putative 0.0063 0.0229 0.0546
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0164 0.3051
Trypanosoma brucei trypanothione reductase 0.0091 0.036 0.3523
Brugia malayi hypothetical protein 0.0022 0.0041 0.0137
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0266 0.0266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0923 0.4201 1
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0039 0.013
Echinococcus multilocularis musashi 0.0058 0.0209 0.0209
Leishmania major DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Plasmodium vivax JmjC domain containing protein 0.0018 0.0023 0.0504
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0076
Loa Loa (eye worm) hypothetical protein 0.0362 0.1609 0.5399
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0041 0.0041
Schistosoma mansoni microtubule-associated protein tau 0.2179 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0039 0.0039
Trypanosoma cruzi cytochrome P450, putative 0.003 0.008 0.0741
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0016 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0064 0.0153
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0359 0.0359
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0181 0.0776 0.0776
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0044 0.0044
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0085 0.0191
Trichomonas vaginalis phosphofructokinase, putative 0.0232 0.1011 0.2408
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0039 0.013
Onchocerca volvulus 0.0061 0.0223 0.0548
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0156 0.037
Entamoeba histolytica transcription factor BTF3, putative 0.011 0.0447 0.1064
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0451 0.2021 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0137
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0039 0.013
Echinococcus multilocularis cpg binding protein 0.0065 0.0239 0.0239
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0085 0.1911
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.0416 0.0416
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0085 0.0797
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0129 0.0432
Onchocerca volvulus 0.0109 0.0441 0.1198
Schistosoma mansoni aldehyde dehydrogenase 0.013 0.0538 0.0538
Loa Loa (eye worm) ICD-1 protein 0.011 0.0447 0.15
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0134 0.0556 0.0556
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0039 0.008
Brugia malayi 6-phosphofructokinase 0.0232 0.1011 0.3393
Echinococcus granulosus dna polymerase kappa 0.0041 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0198
Trichomonas vaginalis glutaminase, putative 0.0312 0.1378 0.3281
Brugia malayi PXA domain containing protein 0.0022 0.0041 0.0137
Entamoeba histolytica hypothetical protein 0.0022 0.0041 0.0097
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0266 0.0266
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0027 0.0027
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0085 0.0797
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0015
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0023 0.0023
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.008 0.0206
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0081 0.1495
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0207 0.0897 0.4297
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0039 0.013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.013
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0039 0.013
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0039 0.0039
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0005 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0039 0.013
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0039 0.0039
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0146 0.3256
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0039 0.0039
Schistosoma mansoni jumonji domain containing protein 0.0067 0.0249 0.0249
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0039 0.0131
Schistosoma mansoni coup transcription factor 0.0021 0.0039 0.0039
Loa Loa (eye worm) POT family protein 0.0083 0.0325 0.1091
Trypanosoma cruzi cytochrome P450, putative 0.003 0.008 0.0741
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0039 0.0039
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0085 0.1954
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0084 0.0283
Brugia malayi Bloom's syndrome protein homolog 0.0046 0.015 0.0504
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0164 0.3674
Brugia malayi Cytochrome P450 family protein 0.0033 0.0094 0.0315
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0016 0.0016
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0085 0.0287
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0041 0.0041
Echinococcus granulosus lamin dm0 0.0058 0.0209 0.0209
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0659 0.2981 1
Trypanosoma cruzi transcription factor btf3, putative 0.011 0.0447 0.4392
Schistosoma mansoni 6-phosphofructokinase 0.0232 0.1011 0.1011
Schistosoma mansoni lamin 0.0058 0.0209 0.0209
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0039 0.0335
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0041 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0923 0.4201 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0473 0.1586
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0039 0.0093
Schistosoma mansoni transcription factor btf3 0.011 0.0447 0.0447
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0085 0.0235
Treponema pallidum NADH oxidase 0.0032 0.0085 0.0112
Echinococcus granulosus mixed lineage leukemia protein mll 0.0019 0.0026 0.0026
Echinococcus multilocularis dna polymerase eta 0.0041 0.0129 0.0129
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0129 0.0306
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0164 0.0391
Loa Loa (eye worm) hypothetical protein 0.0058 0.0209 0.0702
Echinococcus multilocularis microtubule associated protein 2 0.2179 1 1
Brugia malayi 6-phosphofructokinase 0.0232 0.1011 0.3393
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0023 0.0023
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0085 0.0797
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0059 0.0535
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0041 0.0041
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0181 0.0776 0.3719
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0027 0.0051
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0016 0.0054
Brugia malayi hypothetical protein 0.0017 0.0017 0.0057
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0059 0.0535
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0063 0.0229 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0923 0.4201 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0371 0.0989
Echinococcus multilocularis lysine specific demethylase 5A 0.0067 0.0249 0.0249
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0085 0.0203
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0005 0.0005
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0039 0.0871
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0129 0.1227
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0059 0.1321

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.046 uM Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay ChEMBL. 8960546
IC50 (functional) = 0.43 uM Concentration of compound required to inhibit agonist (SFFLRR-NH2, at 18 uM) induced platelet aggregation by 50% ChEMBL. 8960546

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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