Detailed information for compound 251324

Basic information

Technical information
  • TDR Targets ID: 251324
  • Name: 1-[(2-phenyl-7-propan-2-ylimidazo[1,2-a][1,3, 5]triazin-4-yl)amino]propan-2-one
  • MW: 309.366 | Formula: C17H19N5O
  • H donors: 1 H acceptors: 4 LogP: 3.78 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)CNc1nc(nc2n1cc(n2)C(C)C)c1ccccc1
  • InChi: 1S/C17H19N5O/c1-11(2)14-10-22-16(18-9-12(3)23)20-15(21-17(22)19-14)13-7-5-4-6-8-13/h4-8,10-11H,9H2,1-3H3,(H,18,19,20,21)
  • InChiKey: ITKMYMMFUQHXGN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(7-isopropyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-4-yl)amino]propan-2-one
  • 1-[(7-isopropyl-2-phenyl-4-imidazo[1,2-a][1,3,5]triazinyl)amino]-2-propanone
  • 1-[(2-phenyl-7-propan-2-yl-imidazo[1,2-a][1,3,5]triazin-4-yl)amino]propan-2-one
  • 1-[(7-isopropyl-2-phenyl-imidazo[1,2-a][1,3,5]triazin-4-yl)amino]acetone
  • 1-[(2-phenyl-7-propan-2-ylimidazo[2,1-f][1,3,5]triazin-4-yl)amino]propan-2-one
  • 1-[(7-isopropyl-2-phenyl-imidazo[2,1-f][1,3,5]triazin-4-yl)amino]propan-2-one
  • 1-[(7-isopropyl-2-phenyl-4-imidazo[2,1-f][1,3,5]triazinyl)amino]propan-2-one
  • 1-[(7-isopropyl-2-phenyl-imidazo[2,1-f][1,3,5]triazin-4-yl)amino]acetone
  • 1-[(2-phenyl-7-propan-2-yl-imidazo[2,1-f][1,3,5]triazin-4-yl)amino]propan-2-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Adenosine A1 receptor Starlite/ChEMBL References
Homo sapiens adenosine A3 receptor Starlite/ChEMBL References
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 312 aa 24.0 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.3 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 307 aa 21.2 %
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 312 aa 22.1 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A1 receptor   326 aa 318 aa 22.3 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 311 aa 21.9 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 331 aa 25.7 %
Echinococcus multilocularis allatostatin A receptor Adenosine A1 receptor   326 aa 306 aa 26.1 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 277 aa 23.8 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 301 aa 25.6 %
Echinococcus granulosus allatostatin A receptor Adenosine A1 receptor   326 aa 304 aa 25.3 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 311 aa 21.9 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 326 aa 20.2 %
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 315 aa 23.8 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 314 aa 21.7 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 296 aa 22.6 %
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Trypanosoma brucei heat shock protein, putative 0.0079 0.0808 0.4121
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0169 0.1934 0.228
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.027 0.0993
Loa Loa (eye worm) heat shock protein 90 0.0079 0.0808 0.1387
Trypanosoma brucei Heat shock protein 83, putative 0.0079 0.0808 0.4121
Loa Loa (eye worm) hypothetical protein 0.0253 0.2987 0.5128
Loa Loa (eye worm) pyruvate kinase-PB 0.0047 0.0409 0.0702
Loa Loa (eye worm) hypothetical protein 0.0171 0.1961 0.3367
Schistosoma mansoni nAChR subunit 0.0169 0.1934 0.228
Onchocerca volvulus 0.0048 0.042 0.1477
Schistosoma mansoni cpg binding protein 0.0029 0.0186 0.0219
Mycobacterium ulcerans phosphoglycerate kinase 0.0171 0.1961 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0044 0.0374 0.1316
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0169 0.1934 0.332
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0278 0.1418
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0169 0.1934 0.228
Trichomonas vaginalis heat shock protein, putative 0.0079 0.0808 0.4121
Treponema pallidum phosphoglycerate kinase 0.0171 0.1961 1
Trypanosoma brucei heat shock protein 84, putative 0.0044 0.0374 0.1909
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.003 0.0035
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.0609 0.3107
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0091 0.0961 0.165
Loa Loa (eye worm) Smad1 0.0016 0.003 0.0051
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Leishmania major pyruvate kinase 0.0067 0.0662 0.3378
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0081 0.0096
Plasmodium falciparum heat shock protein 90 0.0079 0.0808 0.3721
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Schistosoma mansoni nAChR subunit 0.0169 0.1934 0.228
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.014
Loa Loa (eye worm) hypothetical protein 0.0048 0.042 0.0722
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.0609 0.3107
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0278 0.1418
Brugia malayi DOMON domain containing protein 0.0048 0.0431 0.0739
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0081 0.014
Echinococcus granulosus neuropeptide s receptor 0.0473 0.5735 0.676
Echinococcus granulosus endoplasmin 0.0069 0.069 0.0813
Trypanosoma brucei pyruvate kinase 1, putative 0.0067 0.0662 0.3378
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0169 0.1934 0.228
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0081 0.0081
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0642 0.3274
Loa Loa (eye worm) hypothetical protein 0.0091 0.0961 0.165
Onchocerca volvulus 0.0078 0.0798 0.2805
Schistosoma mansoni pyruvate kinase 0.0067 0.0662 0.0781
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.042 0.2143
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0278 0.1418
Schistosoma mansoni cpg binding protein 0.003 0.0206 0.0243
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0044 0.0374 0.0441
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0081 0.014
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0169 0.1934 0.1934
Trypanosoma brucei heat shock protein, putative 0.0079 0.0808 0.4121
Trypanosoma brucei heat shock protein, putative 0.0079 0.0808 0.4121
Brugia malayi pyruvate kinase, muscle isozyme 0.0014 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0344 0.4124 0.4861
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0036 0.0278 0.0477
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.014
Echinococcus granulosus glycine receptor subunit alpha 1 0.0169 0.1934 0.228
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0081 0.014
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0092 0.097 0.097
Toxoplasma gondii heat shock protein 75, putative 0.0044 0.0374 0.1724
Loa Loa (eye worm) hypothetical protein 0.0092 0.097 0.1665
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0169 0.1934 0.332
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0081 0.0096
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0169 0.1934 0.1934
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1431 0.1686
Trypanosoma brucei heat shock protein 90, putative 0.0079 0.0808 0.4121
Trichomonas vaginalis heat shock protein, putative 0.0069 0.069 0.3517
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.0079 0.0135
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0621 0.0621
Schistosoma mansoni pyruvate kinase 0.0067 0.0662 0.0781
Plasmodium vivax heat shock protein, putative 0.0188 0.2171 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0081 0.0096
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0078 0.0798 0.0941
Echinococcus granulosus pyruvate kinase 0.0034 0.0255 0.0301
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.2824 0.4849
Loa Loa (eye worm) DOMON domain-containing protein 0.0048 0.0431 0.0739
Schistosoma mansoni hypothetical protein 0.0041 0.0336 0.0396
Loa Loa (eye worm) hypothetical protein 0.015 0.17 0.2918
Loa Loa (eye worm) LGC-31 protein 0.0169 0.1934 0.332
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1061 0.125
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0081 0.0096
Echinococcus multilocularis endoplasmin 0.0069 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.014
Echinococcus multilocularis heat shock protein 0.0079 0.0808 0.0808
Echinococcus granulosus glycine receptor subunit beta 0.0169 0.1934 0.228
Trypanosoma brucei phosphoglycerate kinase, putative 0.0063 0.0609 0.3107
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1431 0.1686
Schistosoma mansoni cpg binding protein 0.003 0.0206 0.0243
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0069 0.069 0.3517
Schistosoma mansoni nAChR subunit 0.0078 0.0798 0.0941
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.042 0.2143
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0092 0.097 0.097
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0078 0.0798 0.0798
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0081 0.0096
Brugia malayi MH2 domain containing protein 0.0016 0.003 0.0051
Schistosoma mansoni hypothetical protein 0.0064 0.0621 0.0732
Brugia malayi ecdysteroid receptor 0.0021 0.0081 0.014
Schistosoma mansoni hypothetical protein 0.0064 0.0621 0.0732
Echinococcus multilocularis GPCR, family 2 0.0064 0.0621 0.0621
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0078 0.0798 0.0941
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0662 0.3378
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0081 0.0096
Brugia malayi AMP-binding enzyme family protein 0.0048 0.042 0.0722
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0081 0.014
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0169 0.1934 0.332
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0169 0.1934 0.332
Schistosoma mansoni hypothetical protein 0.0098 0.1049 0.1236
Echinococcus granulosus glycine receptor subunit alpha 1 0.0169 0.1934 0.228
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.003 0.003
Trichomonas vaginalis heat shock protein, putative 0.0053 0.0493 0.2513
Trichomonas vaginalis heat shock protein, putative 0.0069 0.069 0.3517
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.042 0.2143
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0081 0.014
Giardia lamblia Heat shock protein HSP 90-alpha 0.0079 0.0808 0.3242
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.042 0.2143
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0169 0.1934 0.1934
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0246 0.0904
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0081 0.0096
Echinococcus granulosus muscleblind protein 0.015 0.17 0.2003
Onchocerca volvulus 0.0242 0.2845 1
Loa Loa (eye worm) ACC-1 protein 0.0169 0.1934 0.332
Echinococcus granulosus Smad4 0.0016 0.003 0.0035
Schistosoma mansoni hypothetical protein 0.0041 0.0336 0.0396
Plasmodium vivax heat shock protein 86, putative 0.0079 0.0808 0.3721
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.2341 0.4019
Brugia malayi Phosphoglycerate kinase 0.0171 0.1961 0.3367
Trypanosoma brucei phosphoglycerate kinase 0.0063 0.0609 0.3107
Onchocerca volvulus 0.0169 0.1934 0.6797
Echinococcus granulosus glycine receptor subunit alpha 1 0.0169 0.1934 0.228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0081 0.014
Loa Loa (eye worm) hypothetical protein 0.0201 0.2341 0.4019
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Loa Loa (eye worm) hypothetical protein 0.0091 0.0961 0.165
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0169 0.1934 0.228
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0621 0.1067
Brugia malayi Phosphoglycerate kinase 0.0063 0.0609 0.1046
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0307 0.1564
Onchocerca volvulus 0.0078 0.0798 0.2805
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.008 0.0831 0.1426
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Onchocerca volvulus 0.0078 0.0798 0.2805
Trypanosoma brucei heat shock protein 90, putative 0.0079 0.0808 0.4121
Echinococcus multilocularis cpg binding protein 0.003 0.0206 0.0206
Leishmania major heat shock protein, putative 0.0044 0.0374 0.1909
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0078 0.0798 0.137
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0171 0.1961 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0278 0.1418
Plasmodium falciparum pyruvate kinase 0.0067 0.0662 0.3051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0081 0.014
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0078 0.0798 0.137
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Loa Loa (eye worm) hypothetical protein 0.0048 0.042 0.0722
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0169 0.1934 0.1934
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.042 0.2143
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Brugia malayi hypothetical protein 0.0078 0.0798 0.137
Schistosoma mansoni survival motor neuron protein 0.0098 0.1049 0.1236
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0125 0.1382 0.2373
Plasmodium vivax heat shock protein 90, putative 0.0044 0.0374 0.1724
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.042 0.2143
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0662 0.1137
Trypanosoma brucei heat shock protein, putative 0.0079 0.0808 0.4121
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.042 0.2143
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0081 0.014
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0609 0.3107
Schistosoma mansoni hypothetical protein 0.0041 0.0336 0.0396
Loa Loa (eye worm) hypothetical protein 0.0036 0.0278 0.0477
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0277 0.0326
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1431 0.1686
Plasmodium falciparum endoplasmin, putative 0.0053 0.0493 0.2269
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.0463
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.008 0.0831 0.1426
Trichomonas vaginalis heat shock protein, putative 0.004 0.0327 0.1666
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0355 0.1813
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0169 0.1934 0.332
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0355 0.061
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.0798 0.137
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0091 0.0961 0.165
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0081 0.0096
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Brugia malayi Cation transporter family protein 0.0169 0.1934 0.332
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0067 0.0662 0.2438
Schistosoma mansoni hypothetical protein 0.0138 0.1545 0.1821
Schistosoma mansoni peptidylglycine monooxygenase 0.0253 0.2987 0.352
Schistosoma mansoni hypothetical protein 0.0041 0.0336 0.0396
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0128 0.143 0.2454
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.042 0.1547
Echinococcus granulosus expressed conserved protein 0.0093 0.0986 0.1162
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0278 0.0328
Loa Loa (eye worm) hypothetical protein 0.0048 0.042 0.0722
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0169 0.1934 0.332
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1431 0.1686
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0278 0.1418
Schistosoma mansoni Smad4 0.0016 0.003 0.0035
Schistosoma mansoni hypothetical protein 0.0064 0.0621 0.0732
Echinococcus granulosus GPCR family 2 0.0064 0.0621 0.0732
Brugia malayi Smad1 0.0016 0.003 0.0051
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.1431 0.2457
Echinococcus granulosus tar DNA binding protein 0.0129 0.1431 0.1686
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0081 0.0286
Schistosoma mansoni acetylcholine receptor subunit beta 0.0078 0.0798 0.0941
Brugia malayi MH2 domain containing protein 0.0016 0.003 0.0051
Brugia malayi hypothetical protein 0.0036 0.0277 0.0475
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0253 0.2987 0.352
Loa Loa (eye worm) heat shock protein 75 0.0044 0.0374 0.0643
Mycobacterium ulcerans pyruvate kinase 0.0067 0.0662 0.3378
Trypanosoma brucei pyruvate kinase 1 0.0067 0.0662 0.3378
Loa Loa (eye worm) hypothetical protein 0.0052 0.0475 0.0815
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0171 0.1961 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0961 0.165
Schistosoma mansoni nAChR subunit 0.0169 0.1934 0.228
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0099 0.1061 0.1821
Onchocerca volvulus 0.0169 0.1934 0.6797
Schistosoma mansoni hypothetical protein 0.0064 0.0621 0.0732
Entamoeba histolytica hypothetical protein 0.0036 0.0277 0.1411
Onchocerca volvulus 0.0169 0.1934 0.6797
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0081 0.014
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0609 0.3107
Onchocerca volvulus 0.0091 0.0961 0.3379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0081 0.014
Echinococcus granulosus pyruvate kinase 0.0034 0.0255 0.0301
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0169 0.1934 0.332
Loa Loa (eye worm) hypothetical protein 0.0036 0.0278 0.0477
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0169 0.1934 0.1934
Schistosoma mansoni endoplasmin 0.0079 0.0808 0.0952
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0278 0.1023
Brugia malayi Cation transporter family protein 0.0169 0.1934 0.332
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0035
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0081 0.014
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0092 0.097 0.1143
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0081 0.014
Leishmania major hypothetical protein, conserved 0.0036 0.0278 0.1418
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0662 0.3378
Mycobacterium ulcerans lipase LipD 0.0036 0.0278 0.1418
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0081 0.0081
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1061 0.1821
Brugia malayi hypothetical protein 0.0078 0.0798 0.137
Schistosoma mansoni coup transcription factor 0.0021 0.0081 0.0096
Trypanosoma cruzi Heat shock protein 83, putative 0.0079 0.0808 0.4121
Onchocerca volvulus 0.0169 0.1934 0.6797
Entamoeba histolytica phosphoglycerate kinase, putative 0.0171 0.1961 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0069 0.069 0.2538
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0278 0.1418
Schistosoma mansoni smad 0.0016 0.003 0.0035
Loa Loa (eye worm) DOMON domain-containing protein 0.0048 0.0431 0.0739
Loa Loa (eye worm) pyruvate kinase 0.0014 0.0002 0.0003
Brugia malayi Endoplasmin precursor 0.0079 0.0808 0.1387
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0169 0.1934 0.332
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0277 0.0277
Echinococcus multilocularis pyruvate kinase 0.0034 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0042 0.0355 0.061
Mycobacterium ulcerans hypothetical protein 0.0036 0.0278 0.1418
Plasmodium falciparum heat shock protein 90, putative 0.004 0.0327 0.1504
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.0255 0.1174
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0169 0.1934 0.332
Brugia malayi DOMON domain containing protein 0.0048 0.0431 0.0739
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.0463
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.059 0.0695
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0081 0.014
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Plasmodium vivax pyruvate kinase, putative 0.0067 0.0662 0.3051
Echinococcus multilocularis nAChR subunit 0.0091 0.0961 0.0961
Schistosoma mansoni neurotransmitter gated ion channel 0.0078 0.0798 0.0941
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0091 0.0961 0.165
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0078 0.0798 0.0798
Brugia malayi heat shock protein 90 0.0079 0.0808 0.1387
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0171 0.1961 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.2341 0.4019
Trypanosoma cruzi heat shock protein 90, putative 0.0079 0.0808 0.4121
Echinococcus granulosus phosphoglycerate kinase 1 0.0171 0.1961 0.2311
Toxoplasma gondii heat shock protein 90, putative 0.0079 0.0808 0.3721
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.014
Brugia malayi MH2 domain containing protein 0.024 0.2824 0.4849
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0092 0.097 0.4191
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.8484 1
Brugia malayi steroid hormone receptor 0.0021 0.0081 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0278 0.1418
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0169 0.1934 0.1934
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0278 0.1023
Echinococcus multilocularis neuropeptide receptor A26 0.0473 0.5735 0.5735
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.042 0.2143
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0078 0.0798 0.137
Leishmania major phosphoglycerate kinase B, cytosolic 0.0171 0.1961 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0092 0.097 0.1143
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0355 0.0355
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0621 0.1067
Brugia malayi CHE-14 protein 0.0042 0.0355 0.061
Brugia malayi hypothetical protein 0.0078 0.0798 0.137
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0508 0.234
Schistosoma mansoni heat shock protein 0.0044 0.0374 0.0441
Echinococcus multilocularis protein patched 0.0042 0.0355 0.0355
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0169 0.1934 0.332
Mycobacterium tuberculosis Conserved protein 0.0036 0.0278 0.1023
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0081 0.014
Echinococcus multilocularis expressed conserved protein 0.0093 0.0986 0.0986
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.108 0.1273
Trichomonas vaginalis esterase, putative 0.0036 0.0278 0.1418
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0169 0.1934 0.332
Plasmodium falciparum pyruvate kinase 2 0.0034 0.0255 0.1174
Loa Loa (eye worm) hypothetical protein 0.0091 0.0961 0.165
Loa Loa (eye worm) DOMON domain-containing protein 0.0048 0.0431 0.0739
Brugia malayi hypothetical protein 0.048 0.5824 1
Giardia lamblia Pyruvate kinase 0.0067 0.0662 0.2389
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.0798 0.137
Echinococcus multilocularis pyruvate kinase 0.0034 0.0255 0.0255
Trypanosoma cruzi heat shock protein 85, putative 0.0079 0.0808 0.4121
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.1545 0.2653
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0081 0.014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0081 0.014
Brugia malayi beta-lactamase family protein 0.0036 0.0278 0.0477
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0662 0.2328
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1061 0.5409
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0171 0.1961 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0171 0.1961 0.7216
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0169 0.1934 0.228
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0081 0.014
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Mycobacterium tuberculosis Conserved protein 0.0036 0.0278 0.1023
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0169 0.1934 0.332
Brugia malayi nuclear receptor NHR-88 0.0021 0.0081 0.014
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.042 0.2143
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.0463
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0169 0.1934 0.228
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0278 0.1023
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0081 0.0286
Echinococcus multilocularis muscleblind protein 1 0.015 0.17 0.17
Echinococcus multilocularis phosphoglycerate kinase 1 0.0171 0.1961 0.1961
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.003 0.0051
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.027 0.1243
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0278 0.0278
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0092 0.097 0.4467
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0278 0.0328
Echinococcus granulosus geminin 0.0344 0.4124 0.4861
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0169 0.1934 0.332
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0253 0.2987 0.5128
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0081 0.0096
Schistosoma mansoni endoplasmin 0.0079 0.0808 0.0952
Echinococcus granulosus heat shock protein 0.0079 0.0808 0.0952
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0081 0.014
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0081 0.014
Schistosoma mansoni nAChR subunit 0.0169 0.1934 0.228
Entamoeba histolytica hypothetical protein 0.0036 0.0277 0.1411
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0609 0.3107
Brugia malayi beta-lactamase 0.0036 0.0278 0.0477
Schistosoma mansoni heat shock protein 0.0079 0.0808 0.0952
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0081 0.0081
Brugia malayi Pax transcription factor protein 2 0.0242 0.2845 0.4885
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0171 0.1961 0.903
Echinococcus multilocularis pyruvate kinase 0.0067 0.0662 0.0662
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0081 0.0081
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0355 0.0419
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0186 0.0319
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.042 0.2143
Mycobacterium ulcerans beta-lactamase 0.0036 0.0278 0.1418
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.1049 0.1801
Schistosoma mansoni nAChR subunit 0.0078 0.0798 0.0941
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0169 0.1934 0.1934
Loa Loa (eye worm) hypothetical protein 0.0091 0.0961 0.165
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0081 0.014
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0044 0.0374 0.1909
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.042 0.2143
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Loa Loa (eye worm) hypothetical protein 0.0091 0.0961 0.165
Brugia malayi excitatory GABA receptor EXP-1A 0.0169 0.1934 0.332
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0662 0.1137
Onchocerca volvulus Putative nachr subunit 0.0169 0.1934 0.6797
Echinococcus granulosus survival motor neuron protein 1 0.048 0.5824 0.6865
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0081 0.0096
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0091 0.0961 0.1133
Loa Loa (eye worm) hypothetical protein 0.048 0.5824 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.043 0.043
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.027 0.1376
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0048 0.042 0.0722
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.2717 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0278 0.1023
Brugia malayi pyruvate kinase 0.0014 0.0002 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.042 0.2143
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0171 0.1961 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.0798 0.137
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0169 0.1934 0.228
Mycobacterium leprae Probable pyruvate kinase PykA 0.0067 0.0662 0.3378
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.014
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.042 0.2143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0081 0.014
Trypanosoma cruzi heat shock protein 90, putative 0.0065 0.0642 0.3274
Brugia malayi Pyruvate kinase, M2 isozyme 0.0067 0.0662 0.1137
Leishmania major phosphoglycerate kinase C, glycosomal 0.0171 0.1961 1
Onchocerca volvulus 0.0036 0.0278 0.0977
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0169 0.1934 0.332
Entamoeba histolytica pyruvate kinase, putative 0.0047 0.0409 0.2087
Trypanosoma brucei phosphoglycerate kinase 0.0171 0.1961 1
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0253 0.2987 0.2987
Schistosoma mansoni nAChR subunit 0.0169 0.1934 0.228
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0138 0.1545 0.2653
Loa Loa (eye worm) hypothetical protein 0.0253 0.2987 0.5128
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0081 0.014
Toxoplasma gondii pyruvate kinase PyK1 0.0067 0.0662 0.3051
Brugia malayi Pyruvate kinase, muscle isozyme 0.0067 0.0662 0.1137
Schistosoma mansoni hypothetical protein 0.0036 0.0277 0.0326
Brugia malayi AMP-binding enzyme family protein 0.0048 0.042 0.0722
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0081 0.0096
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0662 0.3378
Onchocerca volvulus 0.0021 0.0081 0.0286
Onchocerca volvulus 0.0048 0.0431 0.1513
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0063 0.0609 0.3107
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.003 0.0051
Onchocerca volvulus 0.0091 0.0961 0.3379
Schistosoma mansoni patched 1 0.0042 0.0355 0.0419
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.0463
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Onchocerca volvulus 0.0048 0.0431 0.1513
Echinococcus multilocularis survival motor neuron protein 1 0.048 0.5824 0.5824
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0278 0.1418
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0278 0.0328
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Echinococcus granulosus dnaJ subfamily B 0.0411 0.4958 0.5843
Onchocerca volvulus 0.0036 0.0278 0.0977
Loa Loa (eye worm) hypothetical protein 0.0047 0.0409 0.0702
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.0463
Brugia malayi Muscleblind-like protein 0.015 0.17 0.2918
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0081 0.0286
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0169 0.1934 0.332
Plasmodium vivax phosphoglycerate kinase, putative 0.0171 0.1961 0.903
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0171 0.1961 0.903
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0078 0.0798 0.137
Onchocerca volvulus 0.0036 0.0278 0.0977
Schistosoma mansoni nAChR subunit 0.0169 0.1934 0.228
Loa Loa (eye worm) hypothetical protein 0.0036 0.0278 0.0477
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0621 0.1067
Entamoeba histolytica hypothetical protein 0.0036 0.0277 0.1411
Echinococcus multilocularis muscleblind protein 0.015 0.17 0.17
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0662 0.2328
Echinococcus multilocularis pyruvate kinase 0.0053 0.0486 0.0486
Chlamydia trachomatis pyruvate kinase 0.0067 0.0662 0.2322
Brugia malayi Cation transporter family protein 0.0169 0.1934 0.332
Mycobacterium ulcerans heat shock protein 90 0.0069 0.069 0.3517
Echinococcus multilocularis neuropeptide s receptor 0.0473 0.5735 0.5735
Echinococcus multilocularis heat shock protein 90 0.0079 0.0808 0.0808
Loa Loa (eye worm) ACC-1 protein 0.0169 0.1934 0.332
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0253 0.2987 0.5128
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0169 0.1934 0.332
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0078 0.0798 0.0798
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0169 0.1934 0.228
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0662 0.2328
Onchocerca volvulus 0.0098 0.1049 0.3687
Schistosoma mansoni acetylcholine receptor-related 0.0078 0.0798 0.0941
Plasmodium falciparum phosphoglycerate kinase 0.0171 0.1961 0.903
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0169 0.1934 0.228
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0169 0.1934 0.332
Loa Loa (eye worm) TAR-binding protein 0.0129 0.1431 0.2457
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.042 0.1547
Echinococcus granulosus nAChR subunit 0.0169 0.1934 0.228
Trypanosoma brucei heat shock protein, putative 0.0079 0.0808 0.4121
Loa Loa (eye worm) acetylcholine receptor protein 0.0078 0.0798 0.137
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.0255 0.1174
Loa Loa (eye worm) RNA binding protein 0.0129 0.1431 0.2457
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0169 0.1934 0.1934
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.1431 0.2457
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.008 0.0831 0.0831
Echinococcus multilocularis Smad4 0.0016 0.003 0.003
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.008 0.0831 0.0979
Schistosoma mansoni nAChR subunit 0.0169 0.1934 0.228
Schistosoma mansoni neurotransmitter gated ion channel 0.0078 0.0798 0.0941
Echinococcus granulosus glycine receptor subunit beta 0.0169 0.1934 0.228
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0278 0.0477
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.014
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Trypanosoma brucei heat shock protein, putative 0.0079 0.0808 0.4121
Brugia malayi nuclear hormone receptor 0.0021 0.0081 0.014
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0169 0.1934 0.332
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.1591 0.1875
Loa Loa (eye worm) hypothetical protein 0.015 0.17 0.2918
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Leishmania major pyruvate kinase 0.0067 0.0662 0.3378
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0355 0.0419
Echinococcus multilocularis glycine receptor subunit beta 0.0169 0.1934 0.1934
Loa Loa (eye worm) hypothetical protein 0.0036 0.0278 0.0477
Brugia malayi RNA binding protein 0.0129 0.1431 0.2457
Toxoplasma gondii Hsp90 domain-containing protein 0.0188 0.2171 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0169 0.1934 0.1934
Schistosoma mansoni phosphoglycerate kinase 0.0171 0.1961 0.2311
Trypanosoma brucei heat shock protein, putative 0.0079 0.0808 0.4121
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0091 0.0961 0.1133
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0044 0.0374 0.0374
Echinococcus multilocularis smad 0.0016 0.003 0.003
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0169 0.1934 0.332
Schistosoma mansoni hypothetical protein 0.0344 0.4124 0.4861
Echinococcus granulosus neuropeptide receptor A26 0.0473 0.5735 0.676
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0169 0.1934 0.332
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0169 0.1934 0.228
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0081 0.0096
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.1591 0.1591
Onchocerca volvulus 0.0169 0.1934 0.6797
Brugia malayi CXXC zinc finger family protein 0.0029 0.0186 0.0319
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0091 0.0961 0.165
Plasmodium falciparum heat shock protein 90, putative 0.0188 0.2171 1
Echinococcus granulosus heat shock protein 90 0.0079 0.0808 0.0952
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Entamoeba histolytica heat shock protein 90, putative 0.0079 0.0808 0.4121
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0278 0.1023
Echinococcus multilocularis tar DNA binding protein 0.0129 0.1431 0.1431
Echinococcus multilocularis glycine receptor subunit beta 0.0169 0.1934 0.1934
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.2341 0.4019
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0169 0.1934 0.228
Giardia lamblia Heat shock protein HSP 90-alpha 0.0065 0.0642 0.2269
Brugia malayi hypothetical protein 0.0078 0.0798 0.137
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0621 0.0732
Echinococcus granulosus cpg binding protein 0.003 0.0206 0.0243
Echinococcus granulosus microtubule associated protein 2 0.0693 0.8484 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0278 0.1418
Brugia malayi TAR-binding protein 0.0129 0.1431 0.2457
Brugia malayi MH1 domain containing protein 0.0016 0.003 0.0051
Trichomonas vaginalis endoplasmin, putative 0.0053 0.0493 0.2513
Schistosoma mansoni phosphoglycerate kinase 0.0171 0.1961 0.2311
Echinococcus multilocularis pyruvate kinase 0.0067 0.0662 0.0662
Schistosoma mansoni pyruvate kinase 0.0034 0.0255 0.0301
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0081 0.0096
Echinococcus multilocularis nAChR subunit 0.0169 0.1934 0.1934
Trypanosoma cruzi heat shock protein 85, putative 0.0079 0.0808 0.4121
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0081 0.0096
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0278 0.1023
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0253 0.2987 0.352
Echinococcus granulosus heat shock protein 90 0.0065 0.0642 0.0757
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0169 0.1934 0.332
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0065 0.0642 0.0757
Loa Loa (eye worm) hypothetical protein 0.0091 0.0961 0.165
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Brugia malayi Hsp90 protein 0.0044 0.0374 0.0643
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0169 0.1934 0.228
Onchocerca volvulus 0.0029 0.0186 0.0653
Loa Loa (eye worm) GABA receptor subunit 0.0091 0.0961 0.165
Loa Loa (eye worm) endoplasmin 0.0079 0.0808 0.1387
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Mycobacterium tuberculosis Conserved protein 0.0036 0.0278 0.1023
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1061 0.1061
Schistosoma mansoni dopamine-beta-monooxygenase 0.0479 0.5811 0.6849
Schistosoma mansoni neurotransmitter gated ion channel 0.0091 0.0961 0.1133
Trypanosoma cruzi heat shock protein 85, putative 0.0079 0.0808 0.4121
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0278 0.1418
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0081 0.0081
Loa Loa (eye worm) pax transcription factor protein 2 0.0242 0.2845 0.4885
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0081 0.014
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0277 0.0326
Mycobacterium leprae Probable lipase LipE 0.0036 0.0278 0.1418
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.003 0.0035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0246 0.0904
Echinococcus granulosus pyruvate kinase 0.0034 0.0255 0.0301
Loa Loa (eye worm) beta-lactamase 0.0036 0.0278 0.0477
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0246 0.0904
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0278 0.128
Entamoeba histolytica hypothetical protein 0.0091 0.0961 0.4902
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.027 0.1243
Schistosoma mansoni heat shock protein 0.0079 0.0808 0.0952
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0092 0.097 0.1143
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0081 0.0096
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0064 0.0621 0.1067
Echinococcus multilocularis heat shock protein 90 0.0065 0.0642 0.0642
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Toxoplasma gondii heat shock protein HSP90 0.0079 0.0808 0.3721
Trichomonas vaginalis heat shock protein, putative 0.0065 0.0642 0.3274
Loa Loa (eye worm) hypothetical protein 0.0067 0.0662 0.1137
Echinococcus granulosus smad 0.0016 0.003 0.0035
Giardia lamblia Grp94/Hsp90 0.0069 0.069 0.2548
Onchocerca volvulus 0.0169 0.1934 0.6797
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0169 0.1934 0.332
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0169 0.1934 0.1934
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.2824 0.4849
Brugia malayi DOMON domain containing protein 0.0048 0.0431 0.0739
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0078 0.0798 0.137
Echinococcus multilocularis pyruvate kinase 0.0034 0.0255 0.0255
Giardia lamblia Phosphoglycerate kinase 0.0171 0.1961 1
Echinococcus granulosus nAChR subunit 0.0091 0.0961 0.1133
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0081 0.014
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0278 0.1023
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0278 0.1418
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0662 0.3378
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0621 0.0621
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0081 0.0081
Chlamydia trachomatis phosphoglycerate kinase 0.0171 0.1961 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0621 0.0732
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0081 0.0096
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0081 0.0096
Loa Loa (eye worm) hypothetical protein 0.0036 0.0278 0.0477
Plasmodium vivax endoplasmin, putative 0.0079 0.0808 0.3721
Trypanosoma brucei heat shock protein, putative 0.0079 0.0808 0.4121
Brugia malayi MH1 domain containing protein 0.0016 0.003 0.0051
Echinococcus granulosus pyruvate kinase 0.0067 0.0662 0.0781
Trypanosoma brucei phosphoglycerate kinase 0.0171 0.1961 1
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.8484 0.8484
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.014
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0278 0.0477
Mycobacterium ulcerans hypothetical protein 0.0048 0.042 0.2143
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.042 0.2143
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0035
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.003 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1431 0.1686
Loa Loa (eye worm) hypothetical protein 0.0091 0.0961 0.165
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0662 0.1137
Schistosoma mansoni hypothetical protein 0.0411 0.4958 0.5843
Loa Loa (eye worm) hypothetical protein 0.0091 0.0961 0.165
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.042 0.2143
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Toxoplasma gondii ABC1 family protein 0.0036 0.0278 0.128
Entamoeba histolytica heat shock protein 90, putative 0.0079 0.0808 0.4121
Brugia malayi beta-lactamase family protein 0.0036 0.0278 0.0477
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0169 0.1934 0.228
Echinococcus multilocularis geminin 0.0344 0.4124 0.4124
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0171 0.1961 1
Leishmania major heat shock protein 83-1 0.0079 0.0808 0.4121
Entamoeba histolytica hypothetical protein 0.0036 0.0277 0.1411
Trypanosoma cruzi heat shock protein, putative 0.0044 0.0374 0.1909
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.4958 0.4958
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0246 0.0904
Loa Loa (eye worm) hypothetical protein 0.0169 0.1934 0.332
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0169 0.1934 0.228
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0069 0.069 0.3517
Echinococcus granulosus pyruvate kinase 0.0067 0.0662 0.0781
Brugia malayi hypothetical protein 0.0078 0.0798 0.137
Loa Loa (eye worm) hypothetical protein 0.0078 0.0798 0.137
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.014

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2360 nM Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes. ChEMBL. 12408713
Ki (binding) = 2360 nM Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes. ChEMBL. 12408713
Ki (binding) = 3050 nM Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX. ChEMBL. 12408713
Ki (binding) = 3050 nM Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX. ChEMBL. 12408713
Ki (binding) > 10000 nM Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes. ChEMBL. 12408713
Ki (binding) > 10000 nM Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes. ChEMBL. 12408713

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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