Detailed information for compound 258747

Basic information

Technical information
  • TDR Targets ID: 258747
  • Name: 3-hydroxy-5,8-dimethoxy-1H-quinolin-4-one
  • MW: 221.209 | Formula: C11H11NO4
  • H donors: 2 H acceptors: 3 LogP: 1.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c2c1ncc(c2O)O)OC
  • InChi: 1S/C11H11NO4/c1-15-7-3-4-8(16-2)10-9(7)11(14)6(13)5-12-10/h3-5,13H,1-2H3,(H,12,14)
  • InChiKey: IOCGLBRYFXBXKQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-hydroxy-5,8-dimethoxy-4-quinolone
  • 3-Hydroxy-5,8-dimethoxy-4(1H)-quinolinone
  • 3OH5,8diMeOQuin4one
  • AIDS-005316
  • AIDS005316

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0024 0.0112 0.0097
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0024 0.0112 0.0128
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0919 0.1309
Brugia malayi SH2 domain containing protein 0.0024 0.0112 0.0097
Mycobacterium leprae Probable lipase LipE 0.0039 0.0592 0.1118
Leishmania major hypothetical protein, conserved 0.0039 0.0592 0.0592
Entamoeba histolytica hypothetical protein, conserved 0.0023 0.0093 0.0128
Onchocerca volvulus 0.0039 0.0592 0.124
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0023 0.0093 0.0101
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0592 0.0789
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0322 0.0332
Leishmania major pyruvate kinase 0.0152 0.4144 0.4144
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0089 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0592 0.0592
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0047 0.0843 0.0913
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.1436 0.1962
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.079 0.1858
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0089 0.0072
Brugia malayi STAT protein, DNA binding domain containing protein 0.0024 0.0112 0.0097
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0023 0.0093 0.0077
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0592 0.0633
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0024 0.0112 0.0128
Mycobacterium ulcerans L-lysine aminotransferase 0.0023 0.0096 0.0081
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0114 0.0114
Echinococcus granulosus histone acetyltransferase KAT2B 0.0164 0.451 0.6561
Echinococcus granulosus pyruvate kinase 0.0078 0.1816 0.2621
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0858 0.0858
Onchocerca volvulus 0.0031 0.0322 0.0575
Schistosoma mansoni run and tbc1 domain containing 0.0023 0.0093 0.0077
Schistosoma mansoni tensin-related 0.0024 0.0112 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0089 0.0072
Echinococcus granulosus tyrosine protein kinase Src64B 0.0239 0.6862 1
Echinococcus multilocularis tensin 0.0024 0.0112 0.0128
Brugia malayi SH2 domain containing protein 0.0024 0.0112 0.0097
Schistosoma mansoni sorting nexin 0.0023 0.0093 0.0077
Echinococcus granulosus pyruvate kinase 0.0078 0.1816 0.2621
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1436 0.1575
Echinococcus granulosus N chimaerin 0.0024 0.0112 0.0128
Onchocerca volvulus 0.0024 0.0112 0.0055
Echinococcus multilocularis c src tyrosine kinase 0.0054 0.1053 0.1505
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0024 0.0112 0.0128
Brugia malayi ecdysteroid receptor 0.0023 0.0089 0.0072
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0077
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1436 0.1575
Entamoeba histolytica protein kinase, putative 0.0023 0.0093 0.0128
Echinococcus granulosus tyrosine protein kinase Srms 0.0031 0.0322 0.0436
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0024 0.0112 0.0097
Loa Loa (eye worm) TK protein kinase 0.0191 0.5381 0.5974
Brugia malayi Myosin tail family protein 0.0023 0.0093 0.0077
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0168 0.4659 0.5169
Echinococcus multilocularis SH2 domain containing protein 7 0.0024 0.0112 0.0128
Loa Loa (eye worm) hypothetical protein 0.0031 0.0322 0.0332
Trichomonas vaginalis pyruvate kinase, putative 0.0152 0.4144 0.4595
Schistosoma mansoni hypothetical protein 0.0195 0.549 0.6095
Echinococcus multilocularis tyrosine protein kinase Blk 0.0215 0.613 0.8931
Brugia malayi hypothetical protein 0.0031 0.0322 0.0332
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0239 0.6862 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0024 0.0112 0.0128
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0592 0.0633
Echinococcus multilocularis pyruvate kinase 0.012 0.3136 0.4552
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0592 0.0789
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.0096 0.01
Mycobacterium tuberculosis Conserved hypothetical protein 0.0178 0.4965 0.6866
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0072
Loa Loa (eye worm) TK protein kinase 0.0215 0.613 0.681
Trypanosoma brucei pyruvate kinase 1 0.0152 0.4144 0.413
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0047 0.0843 0.0913
Entamoeba histolytica hypothetical protein 0.0023 0.0093 0.0128
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0164 0.4529 0.5024
Brugia malayi pyruvate kinase, muscle isozyme 0.0032 0.0369 0.0385
Schistosoma mansoni eps8-related protein 0.0023 0.0093 0.0077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0072
Brugia malayi Protein kinase domain containing protein 0.0031 0.0322 0.0332
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0089 0.0072
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0024 0.0112 0.0055
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0093 0.0077
Mycobacterium ulcerans acetylornithine aminotransferase 0.0023 0.0096 0.0081
Leishmania major hypothetical protein, conserved 0.0023 0.0093 0.0093
Entamoeba histolytica hypothetical protein 0.0039 0.0591 0.1058
Brugia malayi beta-lactamase family protein 0.0039 0.0592 0.0633
Brugia malayi nuclear receptor NHR-88 0.0023 0.0089 0.0072
Schistosoma mansoni shc transforming protein 0.0024 0.0112 0.0097
Schistosoma mansoni signal transduction protein lnk-related 0.0024 0.0112 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0089 0.0072
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0089 0.0072
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0215 0.613 0.8931
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0096 0.0106
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.0096 0.0175
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0077
Toxoplasma gondii pyruvate kinase PyK1 0.0152 0.4144 1
Loa Loa (eye worm) protein-tyrosine kinase 0.0023 0.0093 0.0077
Onchocerca volvulus 0.0031 0.0322 0.0575
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0023 0.0093 0.0101
Brugia malayi SH2 domain containing protein 0.0024 0.0112 0.0097
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0024 0.0112 0.0128
Schistosoma mansoni hypothetical protein 0.0024 0.0112 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0093 0.0077
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0592 0.0789
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0215 0.613 0.8931
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0089 0.0072
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0592 0.0633
Brugia malayi Sex muscle abnormal protein 5 0.0047 0.0843 0.0913
Echinococcus multilocularis SH2 motif 0.0024 0.0112 0.0128
Mycobacterium tuberculosis Conserved protein 0.0039 0.0592 0.0789
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0592 0.0633
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0077
Entamoeba histolytica pyruvate kinase, putative 0.0106 0.2697 0.499
Entamoeba histolytica hypothetical protein 0.0023 0.0093 0.0128
Echinococcus multilocularis transfer RNA-Ala 0.0023 0.0093 0.0101
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0089 0.0072
Brugia malayi Protein kinase domain containing protein 0.0031 0.0322 0.0332
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0089 0.0072
Onchocerca volvulus 0.0031 0.0322 0.0575
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0089 0.0072
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0089 0.0095
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0072
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0338 1 1
Onchocerca volvulus 0.0023 0.0093 0.0009
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0592 0.0633
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0.0096 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0024 0.0112 0.0128
Echinococcus multilocularis endophilin A3 0.0023 0.0093 0.0101
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0592 0.1118
Echinococcus granulosus tyrosine protein kinase HCK 0.0191 0.5381 0.7834
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0322 0.0332
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0023 0.0096 0.0081
Echinococcus multilocularis SHC transforming protein 3 0.0024 0.0112 0.0128
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0858 0.0858
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0592 0.0633
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0031 0.0322 0.0436
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0024 0.0112 0.0055
Echinococcus granulosus ornithine aminotransferase 0.0023 0.0096 0.0106
Echinococcus granulosus fch and double sh3 domains protein 2 0.0023 0.0093 0.0101
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0089 0.0072
Loa Loa (eye worm) thyroid receptor interactor 0.0023 0.0093 0.0077
Toxoplasma gondii FATC domain-containing protein 0.0028 0.0237 0.0516
Schistosoma mansoni pyruvate kinase 0.0078 0.1816 0.1999
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0089 0.0072
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Schistosoma mansoni vav2 0.0024 0.0112 0.0097
Entamoeba histolytica BAR/SH3 domain containing protein 0.0023 0.0093 0.0128
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1436 0.1575
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0024 0.0024
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0168 0.4659 0.6778
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.7221 1
Echinococcus multilocularis pyruvate kinase 0.0152 0.4144 0.6025
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0592 0.0789
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0028 0.0237 0.0237
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0239 0.6862 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0209 0.592 0.8623
Echinococcus multilocularis pyruvate kinase 0.0152 0.4144 0.6025
Brugia malayi RhoGAP domain containing protein 0.0024 0.0112 0.0097
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0023 0.0093 0.0101
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0089 0.0095
Toxoplasma gondii pyruvate kinase PyKII 0.0078 0.1816 0.435
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0023 0.0096 0.0081
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0591 0.0829
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0077
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0024 0.0112 0.0097
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0322 0.0332
Loa Loa (eye worm) hypothetical protein 0.0039 0.0592 0.0633
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0093 0.0077
Trypanosoma cruzi pyruvate kinase 2, putative 0.0152 0.4144 0.4144
Entamoeba histolytica hypothetical protein 0.0028 0.0237 0.0397
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Echinococcus granulosus src region 0.0023 0.0093 0.0101
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0164 0.4529 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0592 0.0633
Brugia malayi hypothetical protein 0.0039 0.0591 0.0632
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0089 0.0095
Echinococcus granulosus SH2 motif 0.0024 0.0112 0.0128
Schistosoma mansoni formin binding protein and related proteins 0.0023 0.0093 0.0077
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0089 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0089 0.0072
Onchocerca volvulus 0.0023 0.0093 0.0009
Entamoeba histolytica hypothetical protein 0.0039 0.0591 0.1058
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0239 0.6862 1
Mycobacterium ulcerans lipase LipD 0.0039 0.0592 0.0633
Echinococcus granulosus tyrosine protein kinase Fyn 0.0239 0.6862 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0024 0.0112 0.0128
Echinococcus multilocularis tyrosine protein kinase shark 0.0031 0.0322 0.0436
Schistosoma mansoni tyrosine kinase 0.0239 0.6862 0.7625
Brugia malayi Pyruvate kinase, muscle isozyme 0.0152 0.4144 0.4595
Echinococcus granulosus tyrosine protein kinase ABL1 0.0031 0.0322 0.0436
Schistosoma mansoni tyrosine kinase 0.0054 0.1053 0.1148
Echinococcus multilocularis SH2 motif 0.0024 0.0112 0.0128
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0031 0.0322 0.0436
Loa Loa (eye worm) beta-lactamase 0.0039 0.0592 0.0633
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0089 0.0095
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.016 0.4396 0.4396
Entamoeba histolytica hypothetical protein 0.0023 0.0093 0.0128
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0089 0.0072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.2536 0.3673
Brugia malayi SH2 domain containing protein 0.0024 0.0112 0.0097
Echinococcus multilocularis signal transduction protein lnk realted 0.0024 0.0112 0.0128
Onchocerca volvulus Putative cortactin 0.0023 0.0093 0.0009
Loa Loa (eye worm) pyruvate kinase 0.0152 0.4144 0.4595
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0023 0.0093 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0089 0.0072
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0592 0.083
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0072
Echinococcus granulosus tyrosine protein kinase Fyn 0.0239 0.6862 1
Echinococcus granulosus hypothetical protein 0.0024 0.0112 0.0128
Mycobacterium ulcerans hypothetical protein 0.0039 0.0592 0.0633
Echinococcus granulosus SH2 domain containing protein 7 0.0024 0.0112 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0089 0.0072
Echinococcus multilocularis N chimaerin 0.0024 0.0112 0.0128
Loa Loa (eye worm) pyruvate kinase 0.0152 0.4144 0.4595
Echinococcus granulosus serine protein kinase ATM 0.0028 0.0237 0.0311
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0089 0.0072
Brugia malayi steroid hormone receptor 0.0023 0.0089 0.0072
Schistosoma mansoni glutaminase 0.0306 0.8991 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0919 0.2173
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0024 0.0112 0.0097
Echinococcus granulosus tyrosine kinase 0.0215 0.613 0.8931
Loa Loa (eye worm) pyruvate kinase 0.0152 0.4144 0.4595
Schistosoma mansoni hypothetical protein 0.0023 0.0093 0.0077
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0239 0.6862 1
Loa Loa (eye worm) SRC-1 0.0239 0.6862 0.7625
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0093 0.0077
Echinococcus granulosus SH2 domain containing adapter protein F 0.0024 0.0112 0.0128
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Echinococcus granulosus expressed protein 0.0023 0.0093 0.0101
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0023 0.0093 0.0101
Echinococcus granulosus nostrin 0.0023 0.0093 0.0101
Loa Loa (eye worm) SH2 domain-containing protein 0.0024 0.0112 0.0097
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0089 0.0095
Echinococcus granulosus tyrosine protein kinase Blk 0.0215 0.613 0.8931
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0023 0.0093 0.0101
Brugia malayi nuclear hormone receptor 0.0023 0.0089 0.0072
Schistosoma mansoni coup transcription factor 0.0023 0.0089 0.0072
Echinococcus granulosus tyrosine protein kinase Lyn 0.0239 0.6862 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1436 0.1575
Loa Loa (eye worm) hypothetical protein 0.0039 0.0592 0.0633
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0023 0.0093 0.0101
Echinococcus granulosus NCK adaptor protein 0.0047 0.0843 0.1197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.2536 0.2801
Plasmodium falciparum ornithine aminotransferase 0.0023 0.0096 0.0175
Mycobacterium ulcerans glutaminase 0.0306 0.8991 1
Brugia malayi Protein kinase domain containing protein 0.0031 0.0322 0.0332
Echinococcus multilocularis nostrin 0.0023 0.0093 0.0101
Brugia malayi hypothetical protein 0.0024 0.0112 0.0097
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0023 0.0093 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0093 0.0077
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Brugia malayi protein-tyrosine kinase 0.0023 0.0093 0.0077
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0054 0.1053 0.1505
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0024 0.0112 0.0128
Echinococcus granulosus tensin 0.0024 0.0112 0.0128
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0089 0.0072
Trypanosoma brucei pyruvate kinase 1, putative 0.0152 0.4144 0.413
Schistosoma mansoni cell polarity protein 0.0023 0.0093 0.0077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0077
Entamoeba histolytica hypothetical protein 0.0023 0.0093 0.0128
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0089 0.0072
Loa Loa (eye worm) hypothetical protein 0.0024 0.0114 0.01
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0089 0.0072
Brugia malayi Variant SH3 domain containing protein 0.0047 0.0843 0.0913
Echinococcus multilocularis 0.0024 0.0112 0.0128
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0077
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0239 0.6862 1
Entamoeba histolytica protein kinase, putative 0.0191 0.5381 1
Echinococcus granulosus intersectin 2 0.0023 0.0093 0.0101
Schistosoma mansoni tensin 0.0024 0.0112 0.0097
Echinococcus granulosus suppressor of cytokine signaling 6 0.0024 0.0112 0.0128
Onchocerca volvulus Pyruvate kinase homolog 0.0152 0.4144 1
Onchocerca volvulus 0.0031 0.0322 0.0575
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0096 0.0106
Entamoeba histolytica hypothetical protein, conserved 0.0023 0.0093 0.0128
Schistosoma mansoni suppressor of cytokine signaling 0.0024 0.0112 0.0097
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0592 0.0789
Echinococcus multilocularis pyruvate kinase 0.0078 0.1816 0.2621
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0077
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0047 0.0843 0.0913
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0592 0.0592
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0093 0.0093
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0089 0.0072
Loa Loa (eye worm) glutaminase 2 0.0306 0.8991 1
Entamoeba histolytica hypothetical protein 0.0039 0.0591 0.1058
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0322 0.0332
Loa Loa (eye worm) hypothetical protein 0.0039 0.0592 0.0633
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0089 0.0095
Loa Loa (eye worm) glutaminase 0.0306 0.8991 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0089 0.0095
Entamoeba histolytica hypothetical protein 0.0023 0.0093 0.0128
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0024 0.0024
Schistosoma mansoni C-fyn 0.0023 0.0093 0.0077
Schistosoma mansoni tyrosine kinase 0.0239 0.6862 0.7625
Schistosoma mansoni SH2A 0.0024 0.0112 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.2536 0.2801
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0023 0.0093 0.0101
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.079 0.1858
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0164 0.4529 0.5024
Echinococcus granulosus SH2 motif 0.0024 0.0112 0.0128
Loa Loa (eye worm) acetyltransferase 0.0168 0.4659 0.5169
Echinococcus granulosus endophilin A3 0.0023 0.0093 0.0101
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0024 0.0112 0.0097
Brugia malayi Variant SH3 domain containing protein 0.0024 0.0112 0.0097
Echinococcus granulosus growth factor receptor bound protein 2 0.0047 0.0843 0.1197
Trypanosoma cruzi pyruvate kinase 2, putative 0.0152 0.4144 0.4144
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0239 0.6862 1
Echinococcus granulosus epidermal growth factor receptor kinase 0.0023 0.0093 0.0101
Echinococcus granulosus tyrosine kinase 0.0031 0.0322 0.0436
Brugia malayi Protein kinase domain containing protein 0.0031 0.0322 0.0332
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0303 0.0311
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1436 0.1575
Onchocerca volvulus 0.0023 0.0093 0.0009
Loa Loa (eye worm) hypothetical protein 0.0106 0.2697 0.2981
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0209 0.592 0.8623
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0322 0.0332
Trypanosoma brucei conserved protein 0.0023 0.0093 0.0069
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0858 0.0835
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0089 0.0095
Echinococcus multilocularis serine protein kinase ATM 0.0028 0.0237 0.0311
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0093 0.0077
Echinococcus granulosus geminin 0.0195 0.549 0.7993
Schistosoma mansoni apoptosis stimulating of P53 0.0023 0.0093 0.0077
Onchocerca volvulus 0.0024 0.0112 0.0055
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.1436 0.1436
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0089 0.0072
Brugia malayi Peripheral plasma membrane protein CASK 0.0023 0.0093 0.0077
Brugia malayi cytokine inducible SH2-containing protein 5 0.0024 0.0112 0.0097
Entamoeba histolytica unconventional myosin IB 0.0023 0.0093 0.0128
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0077
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0096 0.0081
Entamoeba histolytica hypothetical protein 0.0023 0.0093 0.0128
Entamoeba histolytica BAR/SH3 domain containing protein 0.0023 0.0093 0.0128
Echinococcus granulosus Aminotransferase class III 0.0023 0.0096 0.0106
Schistosoma mansoni dynamin-associated protein 0.0023 0.0093 0.0077
Mycobacterium ulcerans hypothetical protein 0.0164 0.4529 0.5024
Loa Loa (eye worm) hypothetical protein 0.0039 0.0592 0.0633
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0023 0.0093 0.0101
Entamoeba histolytica hypothetical protein 0.0039 0.0591 0.1058
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.016 0.4396 0.4396
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0239 0.6862 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0077
Plasmodium falciparum pyruvate kinase 0.0152 0.4144 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.079 0.1429
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0592 0.0569
Brugia malayi MH2 domain containing protein 0.014 0.3749 0.4154
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.1436 0.2065
Trichomonas vaginalis pyruvate kinase, putative 0.0152 0.4144 0.4595
Echinococcus multilocularis Aminotransferase class III 0.0023 0.0096 0.0106
Mycobacterium leprae Probable pyruvate kinase PykA 0.0152 0.4144 0.9131
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0089 0.0072
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0028 0.0237 0.0213
Schistosoma mansoni Dab2-interacting protein-like 0.0023 0.0093 0.0077
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0089 0.0095
Trichomonas vaginalis esterase, putative 0.0039 0.0592 0.0633
Echinococcus multilocularis Spectrin alpha actinin 0.0023 0.0093 0.0101
Brugia malayi SH2 domain containing protein 0.0031 0.0322 0.0332
Echinococcus granulosus c src tyrosine kinase 0.0054 0.1053 0.1505
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0089 0.0072
Plasmodium falciparum pyruvate kinase 2 0.0078 0.1816 0.435
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0024 0.0112 0.0097
Onchocerca volvulus 0.0024 0.0112 0.0055
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0031 0.0322 0.0556
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0322 0.0332
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0024 0.0112 0.0128
Onchocerca volvulus Pyruvate kinase homolog 0.0152 0.4144 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0054 0.1053 0.1148
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0089 0.0072
Brugia malayi Guanylate kinase family protein 0.0023 0.0093 0.0077
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0023 0.0093 0.0101
Brugia malayi Tyrosine-protein kinase abl-1 0.0054 0.1053 0.1148
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0093 0.0077
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0322 0.0332
Onchocerca volvulus 0.0024 0.0112 0.0055
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0089 0.0095
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0024 0.0112 0.0097
Brugia malayi Variant SH3 domain containing protein 0.0047 0.0843 0.0913
Schistosoma mansoni tyrosine kinase 0.0054 0.1053 0.1148
Mycobacterium tuberculosis Conserved protein 0.0039 0.0592 0.0789
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0023 0.0093 0.0101
Echinococcus multilocularis NCK adaptor protein 0.0047 0.0843 0.1197
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.0096 0.01
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0089 0.0072
Echinococcus multilocularis geminin 0.0195 0.549 0.7993
Brugia malayi Protein kinase domain containing protein 0.0031 0.0322 0.0332
Loa Loa (eye worm) pyruvate kinase-PB 0.0106 0.2697 0.2981
Echinococcus multilocularis tyrosine kinase 0.0031 0.0322 0.0436
Onchocerca volvulus 0.0031 0.0322 0.0575
Brugia malayi Spectrin alpha chain 0.0023 0.0093 0.0077
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0919 0.0998
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0592 0.0789
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0089 0.0072
Echinococcus multilocularis SH2 motif 0.0024 0.0112 0.0128
Brugia malayi glutaminase DH11.1 0.0306 0.8991 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0047 0.0843 0.1197
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0338 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0101 0.2536 0.2801
Brugia malayi acetyltransferase, GNAT family protein 0.0168 0.4659 0.5169
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0592 0.083
Brugia malayi Pyruvate kinase, M2 isozyme 0.0152 0.4144 0.4595
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0089 0.0072
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0089 0.0072
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0072
Schistosoma mansoni hypothetical protein 0.0195 0.549 0.6095
Toxoplasma gondii hypothetical protein 0.0055 0.1078 0.2557
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0089 0.0095
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0919 0.2173
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0089 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0089 0.0072
Schistosoma mansoni tensin 0.0024 0.0112 0.0097
Schistosoma mansoni GTPase activating protein 0.0024 0.0112 0.0097
Onchocerca volvulus 0.0023 0.0093 0.0009
Entamoeba histolytica hypothetical protein 0.0023 0.0093 0.0128
Loa Loa (eye worm) hypothetical protein 0.0152 0.4144 0.4595
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0024 0.0112 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0093 0.0093
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0023 0.0093 0.0101
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Schistosoma mansoni suppressor of cytokine signaling 0.0024 0.0112 0.0097
Schistosoma mansoni pyruvate kinase 0.0152 0.4144 0.4595
Chlamydia trachomatis pyruvate kinase 0.0152 0.4144 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0024 0.0112 0.0097
Brugia malayi protein-tyrosine kinase 0.0215 0.613 0.681
Schistosoma mansoni tyrosine kinase 0.0031 0.0322 0.0332
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.0096 0.0081
Onchocerca volvulus 0.0024 0.0112 0.0055
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.3749 0.4154
Schistosoma mansoni nck2/grb4 0.0047 0.0843 0.0913
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0322 0.0332
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0093 0.0077
Echinococcus multilocularis expressed protein 0.0023 0.0093 0.0101
Loa Loa (eye worm) hypothetical protein 0.0039 0.0592 0.0633
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0093 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0237 0.0237
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0239 0.6862 1
Giardia lamblia Pyruvate kinase 0.0078 0.1816 0.435
Loa Loa (eye worm) hypothetical protein 0.0047 0.0843 0.0913
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0858 0.0858
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.1436 0.3428
Trichomonas vaginalis glutaminase, putative 0.0306 0.8991 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0592 0.0633
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0028 0.0237 0.0237
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0024 0.0112 0.0163
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0089 0.0095
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0239 0.6862 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0072
Loa Loa (eye worm) guanylate kinase 0.0023 0.0093 0.0077
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0237 0.0237
Echinococcus multilocularis tyrosine protein kinase Abl 0.0054 0.1053 0.1505
Echinococcus granulosus pyruvate kinase 0.0152 0.4144 0.6025
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0322 0.0332
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0089 0.0095
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.1436 0.2065
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0089 0.0095
Echinococcus granulosus pyruvate kinase 0.0078 0.1816 0.2621
Brugia malayi SH2 domain containing protein 0.0024 0.0112 0.0097
Brugia malayi beta-lactamase family protein 0.0039 0.0592 0.0633
Echinococcus granulosus expressed conserved protein 0.0024 0.0112 0.0128
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0089 0.0095
Echinococcus granulosus SHC transforming protein 3 0.0024 0.0112 0.0128
Schistosoma mansoni dreadlocks/dock 0.0023 0.0093 0.0077
Echinococcus granulosus tyrosine protein kinase Fyn 0.0239 0.6862 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.0024 0.0112 0.0128
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0592 0.0633
Plasmodium vivax pyruvate kinase, putative 0.0152 0.4144 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0592 0.0633
Brugia malayi SH2 domain containing protein 0.0024 0.0112 0.0097
Schistosoma mansoni hypothetical protein 0.0039 0.0591 0.0632
Schistosoma mansoni adapter molecule crk 0.0047 0.0843 0.0913
Schistosoma mansoni growth factor receptor-bound protein 0.0047 0.0843 0.0913
Loa Loa (eye worm) hypothetical protein 0.0039 0.0592 0.0633
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0024 0.0024
Echinococcus multilocularis tyrosine protein kinase Srms 0.0215 0.613 0.8931
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0101 0.2536 0.2801
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0024 0.0112 0.0128
Onchocerca volvulus 0.0024 0.0112 0.0055
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0093 0.0077
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.0096 0.0081
Onchocerca volvulus Pyruvate kinase homolog 0.0152 0.4144 1
Trichomonas vaginalis p67phox protein, putative 0.0023 0.0093 0.0077
Mycobacterium ulcerans beta-lactamase 0.0039 0.0592 0.0633
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Echinococcus granulosus tyrosine protein kinase Src42A 0.0239 0.6862 1
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0023 0.0093 0.0077
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.1185 0.1185
Schistosoma mansoni tensin 0.0024 0.0112 0.0097
Brugia malayi tRNA modification GTPase TrmE family protein 0.0024 0.0112 0.0097
Brugia malayi Src substrate cortactin 0.0023 0.0093 0.0077
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0024 0.0112 0.0097
Brugia malayi Fes/CIP4 homology domain containing protein 0.0023 0.0093 0.0077
Brugia malayi beta-lactamase 0.0039 0.0592 0.0633
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0089 0.0095
Entamoeba histolytica SH2 domain containing protein 0.0024 0.0112 0.0163
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0592 0.0633
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0591 0.0632
Brugia malayi Tensin 0.0024 0.0112 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0089 0.0072
Schistosoma mansoni hypothetical protein 0.0023 0.0093 0.0077
Plasmodium vivax pyruvate kinase 2, putative 0.0078 0.1816 0.435
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0592 0.0789
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0046 0.0809 0.0875
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.0096 0.0175
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0919 0.0998
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.2536 0.3673
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0023 0.0093 0.0093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.2536 0.3673
Echinococcus multilocularis pyruvate kinase 0.0078 0.1816 0.2621
Schistosoma mansoni hypothetical protein 0.0024 0.0112 0.0097
Loa Loa (eye worm) TK/FER protein kinase 0.0031 0.0322 0.0332
Toxoplasma gondii ABC1 family protein 0.0039 0.0592 0.1378
Mycobacterium tuberculosis Conserved protein 0.0039 0.0592 0.0789
Entamoeba histolytica hypothetical protein 0.0023 0.0093 0.0128
Schistosoma mansoni growth factor receptor-bound protein 0.0047 0.0843 0.0913
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0089 0.0072
Echinococcus granulosus tyrosine protein kinase shark 0.0031 0.0322 0.0436
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0164 0.4529 0.626
Echinococcus granulosus pyruvate kinase 0.0152 0.4144 0.6025
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0024 0.0112 0.0128
Brugia malayi SRC-1 0.0239 0.6862 0.7625
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0089 0.0072
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0024 0.0112 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0093 0.0077
Echinococcus multilocularis intersectin 2 0.0023 0.0093 0.0101
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0031 0.0322 0.0436
Loa Loa (eye worm) hypothetical protein 0.0023 0.0089 0.0072
Schistosoma mansoni tensin-related 0.0024 0.0112 0.0097
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0023 0.0093 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0097
Giardia lamblia Pyruvate kinase 0.0152 0.4144 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0024 0.0112 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.2536 0.2801
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0096 0.0081
Schistosoma mansoni tyrosine kinase 0.0031 0.0322 0.0332
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0089 0.0072
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.016 0.4396 0.4383
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0023 0.0093 0.0077
Onchocerca volvulus 0.0023 0.0093 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0338 1 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0152 0.4144 0.5725
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0024 0.5
Leishmania major pyruvate kinase 0.0152 0.4144 0.4144
Mycobacterium ulcerans pyruvate kinase 0.0152 0.4144 0.4595
Entamoeba histolytica protein kinase, putative 0.0024 0.0112 0.0163
Onchocerca volvulus 0.0031 0.0322 0.0575
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.2536 0.3673
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0919 0.2173
Echinococcus multilocularis tensin 0.0024 0.0112 0.0128
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0591 0.0829
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0023 0.0093 0.0077
Loa Loa (eye worm) p53BP2 0.0023 0.0093 0.0077
Brugia malayi SH2 domain containing protein 0.0031 0.0322 0.0332
Loa Loa (eye worm) TK/ABL protein kinase 0.0031 0.0322 0.0332
Brugia malayi Variant SH3 domain containing protein 0.0024 0.0112 0.0097
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0239 0.6862 1
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.0096 0.01
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0089 0.0095
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0023 0.0093 0.0009
Echinococcus multilocularis pyruvate kinase 0.0078 0.1816 0.2621
Mycobacterium ulcerans hypothetical protein 0.0178 0.4965 0.5511
Brugia malayi SH2 domain containing protein 0.0024 0.0112 0.0097
Schistosoma mansoni pyruvate kinase 0.0152 0.4144 0.4595
Echinococcus multilocularis tyrosine protein kinase HCK 0.0191 0.5381 0.7834
Echinococcus granulosus signal transduction protein lnk realted 0.0024 0.0112 0.0128
Mycobacterium tuberculosis Probable aminotransferase 0.0164 0.4529 0.626
Echinococcus granulosus Spectrin alpha actinin 0.0023 0.0093 0.0101
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0369 0.0385
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0054 0.1053 0.1505
Brugia malayi pyruvate kinase 0.0032 0.0369 0.0385
Loa Loa (eye worm) SH2 domain-containing protein 0.0024 0.0112 0.0097
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0239 0.6862 1
Brugia malayi SH3 domain containing protein 0.0023 0.0093 0.0077
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.0096 0.01
Onchocerca volvulus 0.0039 0.0592 0.124
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0089 0.0072
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0023 0.0093 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0093 0.0077
Schistosoma mansoni sorbin 0.0023 0.0093 0.0077
Loa Loa (eye worm) STAT protein 0.0024 0.0112 0.0097
Onchocerca volvulus 0.0039 0.0592 0.124
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0592 0.1378
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0093 0.0077
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.3749 0.4154

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) 0 uM Inhibition of RNA-dependent DNA polymerase activity against wildtype HIV-1 RT at a concentration of 100 uM; No inhibition ChEMBL. 10098659

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.