Detailed information for compound 266408

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 666.809 | Formula: C38H46N6O5
  • H donors: 5 H acceptors: 6 LogP: 4.87 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(NC(C(=O)N[C@H](C[C@@H]([C@H](Cc1ccccc1)NC(=O)OCc1cccnc1)O)Cc1ccccc1)C(C)C)NCc1cccc(n1)C
  • InChi: 1S/C38H46N6O5/c1-26(2)35(44-37(47)40-24-31-18-10-12-27(3)41-31)36(46)42-32(20-28-13-6-4-7-14-28)22-34(45)33(21-29-15-8-5-9-16-29)43-38(48)49-25-30-17-11-19-39-23-30/h4-19,23,26,32-35,45H,20-22,24-25H2,1-3H3,(H,42,46)(H,43,48)(H2,40,44,47)/t32-,33-,34-,35?/m0/s1
  • InChiKey: BBZZPVFDYRXRQC-QPMRDEQLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0183 0.0641 0.5714
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0144 0.025
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0216 0.0761 0.131
Treponema pallidum fructose-bisphosphate aldolase 0.0621 0.2259 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0049 0.0144 0.0241
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0028 0.0066 0.0322
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0021 0.0042 0.0191
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.067 0.0755
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.01 0.0334 0.0578
Echinococcus granulosus potassium channel subfamily K 8 0.0049 0.0145 0.0145
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0049 0.0145 0.0252
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0042 0.0042
Brugia malayi Thioredoxin reductase 0.008 0.026 0.0451
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.2259 0.3909
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0171 0.0288
Leishmania major phosphatidylinositol kinase related protein, putative 0.0049 0.0144 0.1839
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0033 0.0037
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0066 0.0322
Echinococcus granulosus geminin 0.0344 0.1235 0.1235
Entamoeba histolytica serine/threonine protein kinase, putative 0.011 0.0368 0.0557
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0023 0.0023
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0049 0.0144 0.1839
Brugia malayi hypothetical protein 0.0019 0.0033 0.0057
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.1104 0.4044 0.7005
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1571 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0217 0.0764 0.0861
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0049 0.0249
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0216 0.0761 0.0761
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0049 0.0144 0.0144
Echinococcus multilocularis mitogen activated protein kinase 14 0.0159 0.0551 0.0551
Schistosoma mansoni two-pore calcium channel 0.0021 0.0042 0.0042
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0171 0.0193
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0042 0.0042
Echinococcus granulosus thioredoxin glutathione reductase 0.0081 0.0264 0.0264
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.052 0.1887 0.1887
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.2259 0.3909
Loa Loa (eye worm) phosphatidylinositol 3 0.0471 0.1706 0.1922
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0042 0.0042
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0049 0.0144 0.0144
Echinococcus granulosus serine:threonine protein kinase PLK1 0.011 0.0368 0.0368
Schistosoma mansoni protein phosphatase 2C 0.0015 0.002 0.002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0204 0.0717 0.6533
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0171 0.0288
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0368 0.0629
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.002 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0049 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0049 0.0206
Trichomonas vaginalis glucosylceramidase, putative 0.0809 0.2954 0.5115
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0049 0.0145 0.0252
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0042 0.0042
Trypanosoma cruzi trypanothione reductase, putative 0.008 0.026 0.0442
Schistosoma mansoni transient receptor potential channel 4 0.0021 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1571 0.577 1
Schistosoma mansoni hypothetical protein 0.0041 0.0116 0.0116
Echinococcus multilocularis conserved hypothetical protein 0.0021 0.0042 0.0042
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0158 0.0158
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0171 0.0288
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0011 0.0006 0.0006
Trypanosoma cruzi target of rapamycin kinase 3 0.0049 0.0144 0.0241
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0021 0.0042 0.0072
Onchocerca volvulus 0.0089 0.0293 0.1524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0011 0.0006 0.0006
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0021 0.0042 0.0191
Mycobacterium tuberculosis Probable dehydrogenase 0.0183 0.0641 0.5821
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0049 0.0144 0.1839
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0042 0.0042
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0028 0.0292
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0066 0.0322
Plasmodium falciparum glutathione reductase 0.008 0.026 0.3373
Leishmania major ion transport protein-like protein 0.0049 0.0145 0.185
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0177 0.0177
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0042 0.0042
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0144 0.1839
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0159 0.0551 0.0621
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0049 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0011 0.0006 0.0006
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0204 0.0717 0.6533
Echinococcus granulosus transient receptor potential gamma protein 0.0021 0.0042 0.0042
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0023 0.0023
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0049 0.0145 0.0242
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0171 0.0288
Schistosoma mansoni twik family of potassium channels-related 0.0049 0.0145 0.0145
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0988 0.3613 0.3613
Toxoplasma gondii NADPH-glutathione reductase 0.0028 0.0066 0.0802
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0033 0.0033
Giardia lamblia Fructose-bisphosphate aldolase 0.0621 0.2259 0.7738
Onchocerca volvulus 0.0049 0.0144 0.075
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.002 0.0023
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0025 0.0056 0.0056
Brugia malayi hypothetical protein 0.0041 0.0116 0.0201
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0028 0.0066 0.0066
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.2715 1 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0021 0.0042 0.0047
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0049 0.0145 0.0168
Schistosoma mansoni hypothetical protein 0.01 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0049 0.0144 0.0163
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Echinococcus multilocularis geminin 0.0344 0.1235 0.1235
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0144 0.0738
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.052 0.1887 0.327
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0056 0.0056
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.002 0.0023
Loa Loa (eye worm) TWK-7 protein 0.0049 0.0145 0.0164
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0042 0.0042
Echinococcus multilocularis phd:f box containing protein 0.0015 0.002 0.002
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0042 0.0042
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0025 0.0056 0.0056
Loa Loa (eye worm) voltage-gated potassium channel 0.0021 0.0042 0.0047
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0049 0.0144 0.0738
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0023 0.0023
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0025 0.0056 0.0056
Leishmania major hypothetical protein, conserved 0.0049 0.0145 0.185
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0049 0.0144 0.0241
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0621 0.2259 0.3862
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0028 0.0066 1
Echinococcus granulosus phd:f box containing protein 0.0015 0.002 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0809 0.2954 0.5115
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0049 0.0144 0.0738
Plasmodium falciparum thioredoxin reductase 0.008 0.026 0.3373
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0056 0.0056
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0049 0.0144 0.0738
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.067 0.1161
Brugia malayi isocitrate dehydrogenase 0.0016 0.0023 0.004
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0216 0.0761 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0204 0.0717 0.6533
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0042 0.0042
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0216 0.0761 0.1318
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0144 0.1839
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0021 0.0042 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0144 0.0144
Giardia lamblia Phosphatidylinositol 4-kinase 0.0049 0.0144 0.0477
Giardia lamblia Hypothetical protein 0.0049 0.0145 0.048
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0042 0.0042
Schistosoma mansoni transient receptor potential channel 0.0022 0.0044 0.0044
Leishmania major calcium/potassium channel (CAKC), putative 0.0049 0.0145 0.185
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0042 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0024 0.0011
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0066 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0023
Echinococcus granulosus ryanodine receptor 44f 0.0021 0.0042 0.0042
Leishmania major hypothetical protein, conserved 0.0049 0.0144 0.1839
Schistosoma mansoni polycystin 1-related 0.0019 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0144 0.025
Brugia malayi glutathione reductase 0.008 0.026 0.0451
Schistosoma mansoni intermediate filament proteins 0.0089 0.0293 0.0293
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0066 0.0105
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0037
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0041 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0041 0.0117 0.0131
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0044 0.0044
Plasmodium vivax JmjC domain containing protein 0.0015 0.002 0.0194
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0084 0.1037
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0021 0.0042 0.0072
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0021 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Onchocerca volvulus 0.0049 0.0145 0.0755
Echinococcus multilocularis ryanodine receptor 44f 0.0021 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0049 0.0144 0.0241
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0025 0.0056 0.0063
Echinococcus multilocularis 0.0049 0.0144 0.0144
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.002 0.0039 0.0067
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.0006 0.0006
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0216 0.0761 0.131
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0028 0.0066 0.0364
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.067 0.067
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.002 0.002
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0011 0.0006 0.0006
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0621 0.2259 0.3862
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0171 0.2195
Brugia malayi ion channel NompC 0.0021 0.0042 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Plasmodium vivax potassium channel, putative 0.0049 0.0145 0.185
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.1144 0.4193 0.7266
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0042 0.0042
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0049 0.0145 0.0252
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0053 0.016 0.0267
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0011 0.0006 0.0006
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0216 0.0761 1
Echinococcus granulosus small conductance calcium activated potassium 0.1011 0.3699 0.3699
Echinococcus granulosus short transient receptor potential channel 6 0.0021 0.0042 0.0042
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1266 0.4644 0.8032
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0177 0.0177
Loa Loa (eye worm) thioredoxin reductase 0.008 0.026 0.0293
Schistosoma mansoni hypothetical protein 0.01 0.0334 0.0334
Onchocerca volvulus 0.0049 0.0145 0.0755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0049 0.0145 0.0252
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0021 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Brugia malayi olfactory channel protein osm-9 0.0022 0.0044 0.0077
Echinococcus granulosus transient receptor potential cation channel 0.0022 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0049 0.0144 0.0163
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0021 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.2715 1 1
Loa Loa (eye worm) hypothetical protein 0.0584 0.212 0.2389
Onchocerca volvulus 0.0023 0.0049 0.0257
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0049 0.0144 0.1839
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0049 0.0145 0.0252
Schistosoma mansoni calcium-activated potassium channel 0.0049 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0455 0.1644 0.1852
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0056 0.0056
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Brugia malayi MAP kinase sur-1 0.0056 0.0171 0.0297
Schistosoma mansoni hypothetical protein 0.0217 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Loa Loa (eye worm) hypothetical protein 0.0088 0.0287 0.0324
Echinococcus granulosus twik family of potassium channels 0.0049 0.0145 0.0145
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.0368 0.0629
Schistosoma mansoni lamin 0.0089 0.0293 0.0293
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0049 0.0145 0.0252
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0144 0.0241
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0021 0.0042 0.0042
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0021 0.0042 0.0042
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0056 0.0056
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0159 0.0551 0.7218
Leishmania major trypanothione reductase 0.008 0.026 0.3373
Echinococcus granulosus sodium channel protein 0.0021 0.0042 0.0042
Echinococcus granulosus two pore calcium channel protein 1 0.0021 0.0042 0.0042
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0025 0.0056 0.0056
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0028 0.0066 0.0066
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0049 0.0144 0.0144
Toxoplasma gondii hypothetical protein 0.0021 0.0042 0.0475
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0144 0.0163
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0809 0.2954 0.5115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0066 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0166 0.0278
Giardia lamblia Hypothetical protein 0.0049 0.0144 0.0477
Brugia malayi hypothetical protein 0.0021 0.0042 0.0072
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0042 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.056 0.2032 0.3514
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0042 0.0042
Brugia malayi hypothetical protein 0.0019 0.0033 0.0057
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0033 0.0033
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0049 0.0145 0.0145
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0049 0.0145 0.0252
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0025 0.0056 0.0087
Echinococcus granulosus mitogen activated protein kinase 11 0.0159 0.0551 0.0551
Brugia malayi Cyclic-nucleotide gated cation channel 0.0025 0.0056 0.0097
Schistosoma mansoni twik family of potassium channels-related 0.0049 0.0145 0.0145
Brugia malayi jmjC domain containing protein 0.0015 0.002 0.0035
Schistosoma mansoni calcium-activated potassium channel 0.0961 0.3517 0.3517
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0471 0.1706 0.2949
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Echinococcus multilocularis voltage dependent calcium channel 0.0021 0.0042 0.0042
Leishmania major phosphatidylinositol 3-kinase, putative 0.0049 0.0144 0.1839
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0025 0.0056 0.0056
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0049 0.0144 0.1839
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.002 0.002
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0049 0.0145 0.0252
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0049 0.0144 0.0144
Echinococcus granulosus shaker cognate 0.0021 0.0042 0.0042
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0049 0.0145 0.0252
Brugia malayi intermediate filament protein 0.0089 0.0293 0.0509
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0042 0.0042
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.1104 0.4044 0.7005
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0049 0.0206
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0021 0.0042 0.0042
Schistosoma mansoni voltage-dependent calcium channel 0.0021 0.0042 0.0042
Trypanosoma cruzi ion transport protein, putative 0.0049 0.0145 0.0242
Schistosoma mansoni hypothetical protein 0.0049 0.0145 0.0145
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0049 0.0145 0.0252
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0021 0.0042 0.0042
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0031
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0028 0.0066 0.0802
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0025 0.0056 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.002 0.002
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0049 0.0144 0.0166
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0011 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0216 0.0761 0.0761
Loa Loa (eye worm) hypothetical protein 0.1011 0.3699 0.4168
Plasmodium vivax hypothetical protein 0.0049 0.0144 0.1839
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.052 0.1887 0.3212
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.011 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0988 0.3613 0.4072
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0021 0.0042 0.0062
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0028 0.0066 0.0802
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1926 0.3331
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0049 0.0144 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0144 0.0241
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0216 0.0761 0.0761
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0203 0.0715 0.0715
Onchocerca volvulus 0.0049 0.0144 0.075
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1926 0.3331
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0025 0.0056 0.0087
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0025 0.0056 0.0056
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0021 0.0042 0.0072
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0049 0.0145 0.0252
Echinococcus multilocularis transient receptor potential cation channel 0.0022 0.0044 0.0044
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0809 0.2954 0.3329
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0033 0.0033
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0023 0.0023
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0028 0.0066 0.0802
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1571 0.577 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0042 0.0042
Echinococcus multilocularis twik family of potassium channels 0.0049 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0037
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1812 0.6662 0.6662
Toxoplasma gondii thioredoxin reductase 0.008 0.026 0.3373
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0049 0.0144 0.1839
Echinococcus multilocularis transient receptor potential gamma protein 0.0021 0.0042 0.0042
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0183 0.0641 0.5821
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0049 0.0144 0.0144
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0049 0.0144 0.0144
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.0368 0.0629
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0049 0.0145 0.0252
Brugia malayi jmjC domain containing protein 0.0015 0.002 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0021 0.0042 0.0072
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0021 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0049 0.0145 0.0145
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.002 0.0039 0.0067
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.047 0.0529
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1926 0.3331
Brugia malayi Muscleblind-like protein 0.016 0.0555 0.0961
Echinococcus granulosus RUN 0.0019 0.0033 0.0033
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.052 0.1887 0.3263
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0028 0.0066 0.0802
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0049 0.0145 0.0164
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0049 0.0144 0.0144
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0368 0.0629
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0024 0.0011
Entamoeba histolytica hypothetical protein 0.1266 0.4644 0.8032
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0023 0.0092
Loa Loa (eye worm) hypothetical protein 0.016 0.0555 0.0625
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0056
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0021 0.0042 0.0042
Schistosoma mansoni twik family of potassium channels-related 0.0049 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0023
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0116 0.0116
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0021 0.0042 0.0042
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0033 0.0033
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0042 0.0042
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0049 0.0144 0.1839
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0144 0.0163
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0171 0.2195
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0023 0.023
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0317 0.1134 0.1278
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1571 0.577 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0144 0.0144
Entamoeba histolytica hypothetical protein 0.0049 0.0144 0.0166
Giardia lamblia NADH oxidase lateral transfer candidate 0.0028 0.0066 0.0208
Echinococcus multilocularis RUN 0.0019 0.0033 0.0033
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0144 0.0166
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0021 0.0042 0.0072
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0049 0.0581
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0177 0.0177
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0216 0.0761 0.0761
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0066 0.0105
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0053 0.016 0.0267
Echinococcus multilocularis voltage gated potassium channel 0.0025 0.0056 0.0056
Leishmania major hypothetical protein, conserved 0.0021 0.0042 0.0475
Loa Loa (eye worm) hypothetical protein 0.0317 0.1134 0.1278
Echinococcus granulosus voltage dependent calcium channel 0.0021 0.0042 0.0042
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.011 0.0368 0.48
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.067 0.067
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0042 0.0042
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0025 0.0056 0.0056
Onchocerca volvulus 0.0021 0.0042 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0042 0.0042
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0204 0.0717 0.6445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Loa Loa (eye worm) ryanodine receptor 0.0021 0.0042 0.0047
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0049 0.0145 0.0252
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.002 0.002
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0177 0.0177
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0049 0.0206
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0023
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0049 0.0144 0.0241
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.01 0.0334 0.0334
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0021 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.01 0.0334 0.0334
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0084 0.1037
Brugia malayi MH2 domain containing protein 0.0137 0.047 0.0814
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0368 0.0629
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0042 0.0042
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0159 0.0551 0.0945
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0303 0.1085 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Loa Loa (eye worm) PDE1B protein 0.0203 0.0715 0.0806
Schistosoma mansoni jumonji domain containing protein 0.0015 0.002 0.002
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0171 0.0171
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0042 0.0042
Plasmodium falciparum potassium channel 0.0049 0.0145 0.185
Loa Loa (eye worm) intermediate filament protein 0.0089 0.0293 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.067 0.067
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0042 0.0042
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0021 0.0042 0.0072
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0303 0.1085 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.2259 0.3909
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0317 0.1134 0.1965
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0988 0.3613 0.6262
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0042 0.0042
Echinococcus multilocularis potassium channel subfamily K 0.0049 0.0145 0.0145
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0354 0.1271 0.4344
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0023 0.023
Schistosoma mansoni hypothetical protein 0.0344 0.1235 0.1235
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0021 0.0042 0.0042
Onchocerca volvulus 0.0049 0.0145 0.0755
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0033 0.0359
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1522 0.5589 0.9683
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0144 0.0166
Echinococcus granulosus potassium channel subfamily K 8 0.0049 0.0145 0.0145
Leishmania major phosphatidylinositol kinase, putative 0.0049 0.0144 0.1839
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0049 0.0144 0.1839
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0049 0.0145 0.0252
Echinococcus multilocularis small conductance calcium activated potassium 0.1011 0.3699 0.3699
Echinococcus granulosus sodium leak channel non selective protein 0.0021 0.0042 0.0042
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0144 0.0163
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0049 0.0145 0.0164
Brugia malayi Latrophilin receptor protein 2 0.01 0.0334 0.0578
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.01 0.0334 0.0334
Schistosoma mansoni rab6-interacting 0.0019 0.0033 0.0033
Echinococcus granulosus short transient receptor potential channel 6 0.0022 0.0044 0.0044
Echinococcus granulosus potassium channel subfamily K 0.0049 0.0145 0.0145
Plasmodium falciparum glutathione reductase 0.0028 0.0066 0.0802
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0011 0.0006 0.0006
Echinococcus multilocularis sodium leak channel non selective protein 0.0021 0.0042 0.0042
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0049 0.0144 0.0241
Echinococcus multilocularis calcium activated potassium channel 0.0023 0.0047 0.0047
Onchocerca volvulus 0.0049 0.0145 0.0755
Loa Loa (eye worm) hypothetical protein 0.0043 0.0123 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0089 0.0293 0.0331
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0216 0.0761 0.4014
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.011 0.0368 0.0415
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0049 0.0086
Loa Loa (eye worm) voltage-gated potassium channel 0.0021 0.0042 0.0047
Schistosoma mansoni transient receptor potential channel 0.0021 0.0042 0.0042
Leishmania major phosphatidylinositol 3-kinase, putative 0.0216 0.0761 1
Echinococcus multilocularis shaker cognate 0.0021 0.0042 0.0042
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0021 0.0042 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0171 0.0171
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0171 0.0171
Echinococcus multilocularis thioredoxin glutathione reductase 0.0081 0.0264 0.0264
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0025 0.0056 0.0097
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.01 0.0334 0.0334
Schistosoma mansoni twik family of potassium channels-related 0.0049 0.0145 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0368 0.0368
Toxoplasma gondii ion channel protein 0.0049 0.0145 0.185
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Schistosoma mansoni hypothetical protein 0.1011 0.3699 0.3699
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.052 0.1887 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Echinococcus multilocularis muscleblind protein 1 0.016 0.0555 0.0555
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0171 0.0288
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0021 0.0042 0.0072
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0006 0.0006
Brugia malayi jmjC domain containing protein 0.0058 0.0177 0.0307
Schistosoma mansoni twik family of potassium channels-related 0.0049 0.0145 0.0145
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0049 0.0145 0.0252
Schistosoma mansoni hypothetical protein 0.0049 0.0144 0.0144
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0023 0.0023
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0023 0.0026
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0042 0.0042
Echinococcus granulosus calcium activated potassium channel variant 0.0049 0.0145 0.0145
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0028 0.0066 0.0066
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0144 0.025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0024 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0368 0.0629
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0116 0.0116
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0021 0.0042 0.0042
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.002 0.0194
Loa Loa (eye worm) hypothetical protein 0.0178 0.062 0.0699
Leishmania major potassium channel subunit-like protein 0.0049 0.0145 0.185
Brugia malayi hypothetical protein 0.0049 0.0145 0.0252
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0006
Onchocerca volvulus 0.0049 0.0145 0.0755
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0043 0.0123 0.0123
Brugia malayi latrophilin 2 splice variant baaae 0.0217 0.0764 0.1323
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0049 0.0249
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.2259 0.3909
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0042 0.0042
Leishmania major hypothetical protein, unknown function 0.0021 0.0042 0.0475
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0021 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0021 0.0042 0.0042
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0144 0.0163
Echinococcus granulosus intermediate filament protein 0.0089 0.0293 0.0293
Echinococcus granulosus calcium activated potassium channel 0.0023 0.0047 0.0047
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0049 0.0145 0.0145
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0049 0.0206
Leishmania major hypothetical protein, unknown function 0.0049 0.0144 0.1839
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0216 0.0761 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0023 0.023
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0023 0.023
Loa Loa (eye worm) calcium channel 0.0021 0.0042 0.0047
Onchocerca volvulus 0.0019 0.0033 0.017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0144 0.025
Loa Loa (eye worm) hypothetical protein 0.0025 0.0056 0.0063
Schistosoma mansoni calcium-activated potassium channel 0.0049 0.0145 0.0145
Entamoeba histolytica hypothetical protein 0.0049 0.0144 0.0166
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Brugia malayi N-terminal motif family protein 0.0178 0.062 0.1075
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0042 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0049 0.0086
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0171 0.0881
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0171 0.0288
Schistosoma mansoni lamin 0.0089 0.0293 0.0293
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0025 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0049 0.0144 0.0144
Mycobacterium tuberculosis Probable reductase 0.0183 0.0641 0.5821
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0166 0.0278
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0216 0.0761 0.131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0023 0.004
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0021 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0025 0.0056 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0066 0.0105
Trichomonas vaginalis mercuric reductase, putative 0.0028 0.0066 0.0105
Plasmodium vivax thioredoxin reductase, putative 0.008 0.026 0.3373
Loa Loa (eye worm) glutathione reductase 0.008 0.026 0.0293
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.047 0.0529
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0028 0.0066 0.0407
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.002 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.2259 0.3909
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0049 0.0144 0.0738
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.067 0.067
Schistosoma mansoni hypothetical protein 0.01 0.0334 0.0334
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0023 0.0023
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0183 0.0641 0.5821
Brugia malayi cytoplasmic intermediate filament protein 0.0048 0.014 0.0243
Leishmania major hypothetical protein, conserved 0.0015 0.002 0.0194
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0145 0.0242
Plasmodium vivax potassium channel, putative 0.0049 0.0145 0.185
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0042 0.0042
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0021 0.0042 0.0216
Onchocerca volvulus 0.0089 0.0293 0.1524
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0216 0.0761 0.0857
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0023 0.0092
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0049 0.0145 0.0242
Schistosoma mansoni twik family of potassium channels-related 0.0049 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Echinococcus granulosus twik family of potassium channels 0.0049 0.0145 0.0145
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0042 0.0042
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1571 0.577 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.052 0.1887 0.3263
Loa Loa (eye worm) voltage-gated calcium channel 0.0021 0.0042 0.0047
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0025 0.0056 0.0056
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0049 0.0145 0.0252
Echinococcus multilocularis two pore calcium channel protein 2 0.0021 0.0042 0.0042
Echinococcus multilocularis mitogen activated protein kinase 11 0.0159 0.0551 0.0551
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0144 0.025
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0021 0.0042 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1926 0.3331
Trichomonas vaginalis glucosylceramidase, putative 0.0809 0.2954 0.5115
Echinococcus granulosus lamin 0.0089 0.0293 0.0293
Loa Loa (eye worm) phosphatidylinositol 3 0.2411 0.8874 1
Schistosoma mansoni vesicular amine transporter 0.0021 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0049 0.0144 0.0241
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0025 0.0056 0.0056
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0049 0.0145 0.0242
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0177 0.0177
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.2259 0.3909
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0011 0.0006 0.0006
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0799 0.2918 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0049 0.0144 0.0144
Echinococcus granulosus serine protein kinase ATM 0.0049 0.0144 0.0144
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0216 0.0761 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.0144 0.1144
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0028 0.0044
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0025 0.0056 0.0097
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0049 0.0144 0.0241
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0049 0.0144 0.0166
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.008 0.026 0.2235
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0028 0.0066 0.0364
Entamoeba histolytica hypothetical protein 0.0041 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0049 0.0144 0.0163
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0144 0.0144
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0042 0.0042
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0049 0.0144 0.1839
Schistosoma mansoni fkbp-rapamycin associated protein 0.0049 0.0144 0.0144
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0216 0.0761 0.1243
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.0006 0.0006
Brugia malayi hypothetical protein 0.0049 0.0145 0.0252
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0021 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0066 0.0105
Loa Loa (eye worm) ion channel NompC 0.0021 0.0042 0.0047
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.052 0.1887 0.3263
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0368 0.0629
Echinococcus multilocularis sodium channel protein 0.0021 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0144 0.0163
Echinococcus multilocularis short transient receptor potential channel 6 0.0021 0.0042 0.0042
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0183 0.0641 0.5821
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0216 0.0761 0.131
Brugia malayi cation channel family protein 0.0021 0.0042 0.0072
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0025 0.0056 0.0056
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.062 0.322
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0049 0.0145 0.0252
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Echinococcus granulosus voltage gated hydrogen channel 1 0.0021 0.0042 0.0042
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.01 0.0334 0.0334
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1926 0.3331
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1926 0.3331
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0042 0.0042
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0042 0.0042
Giardia lamblia GTOR 0.0049 0.0144 0.0477
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.002 0.0194
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0025 0.0056 0.0056
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0203 0.0715 0.1239
Toxoplasma gondii hypothetical protein 0.0021 0.0042 0.0475
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0056 0.0056
Echinococcus multilocularis hyperpolarization activated cyclic 0.0025 0.0056 0.0056
Brugia malayi serine/threonine-protein kinase plk-2 0.011 0.0368 0.0638
Echinococcus multilocularis calcium activated potassium channel variant 0.0049 0.0145 0.0145
Echinococcus multilocularis potassium channel subfamily K 8 0.0049 0.0145 0.0145
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0042 0.0042
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0144 0.025
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0043 0.0123 0.0123
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0033 0.0359
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0177 0.0177
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0216 0.0761 0.131
Entamoeba histolytica hypothetical protein 0.0041 0.0116 0.0116
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0116 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Entamoeba histolytica protein kinase rad3, putative 0.0049 0.0144 0.0166
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1571 0.577 1
Toxoplasma gondii transporter, cation channel family protein 0.0021 0.0042 0.0475
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0031
Toxoplasma gondii transporter, cation channel family protein 0.0021 0.0042 0.0475
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0021 0.0042 0.0072
Echinococcus multilocularis hyperpolarization activated cyclic 0.0025 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0089 0.0293 0.0331
Loa Loa (eye worm) hypothetical protein 0.01 0.0334 0.0376
Loa Loa (eye worm) hypothetical protein 0.0507 0.1836 0.2069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0049 0.0144 0.0241
Echinococcus granulosus two pore calcium channel protein 2 0.0021 0.0042 0.0042
Echinococcus granulosus hypothetical protein 0.0021 0.0042 0.0042
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0028 0.0066 0.0802
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0159 0.0551 0.0945
Loa Loa (eye worm) uncoordinated protein 58 0.0049 0.0145 0.0164
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Echinococcus granulosus voltage gated potassium channel 0.0025 0.0056 0.0056
Schistosoma mansoni phd/f-box containing protein 0.0015 0.002 0.002
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0049 0.0144 0.1839
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.002 0.002
Plasmodium vivax glutathione reductase, putative 0.008 0.026 0.3373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.052 0.1887 0.3212
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0049 0.0206
Echinococcus multilocularis potassium large conductance calcium activated 0.0021 0.0042 0.0042
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0011 0.0006 0.0006
Schistosoma mansoni lipoxygenase 0.0053 0.0158 0.0158
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0049 0.0145 0.0743
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0056
Toxoplasma gondii target of rapamycin (TOR), putative 0.0049 0.0144 0.1839
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0031
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.002 0.002
Echinococcus multilocularis muscleblind protein 0.016 0.0555 0.0555
Echinococcus multilocularis twik family of potassium channels 0.0049 0.0145 0.0145
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0049 0.0144 0.0738
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0144 0.0163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.2259 0.3909
Onchocerca volvulus Glucosylceramidase homolog 0.0531 0.1926 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0053 0.016 0.0267
Echinococcus granulosus mitogen activated protein kinase 14 0.0159 0.0551 0.0551
Schistosoma mansoni ryanodine receptor related 0.0021 0.0042 0.0042
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0011 0.0006 0.0006
Brugia malayi jmjC domain containing protein 0.0015 0.002 0.0035
Brugia malayi Doublecortin family protein 0.0019 0.0033 0.0057
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.052 0.1887 0.3263
Schistosoma mansoni twik family of potassium channels-related 0.0049 0.0145 0.0145
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0066 0.0105
Echinococcus granulosus muscleblind protein 0.016 0.0555 0.0555
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0171 0.0288
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0144 0.0241
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0042 0.0042
Brugia malayi voltage-dependent calcium channel 0.0021 0.0042 0.0072
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0042 0.0042
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0042 0.0042
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0011 0.0006 0.0006
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0988 0.3613 0.3613
Schistosoma mansoni kinase 0.0056 0.0171 0.0171
Echinococcus multilocularis mitogen activated protein kinase 14 0.0159 0.0551 0.0551
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0021 0.0042 0.0042
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0042 0.0042
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0011 0.0006 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0049 0.0581
Brugia malayi Calcitonin receptor-like protein seb-1 0.0317 0.1134 0.1965
Schistosoma mansoni hypothetical protein 0.0019 0.0033 0.0033
Schistosoma mansoni voltage-gated ion channel 0.0021 0.0042 0.0042
Trypanosoma brucei calcium-activated potassium channel, putative 0.0049 0.0145 0.0743
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.2259 0.3909
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0042 0.0042
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0025 0.0056 0.0056
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0021 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Loa Loa (eye worm) hypothetical protein 0.0041 0.0117 0.0131
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0171 0.2195
Entamoeba histolytica hypothetical protein 0.0049 0.0144 0.0166
Brugia malayi P38 map kinase family protein 2 0.0159 0.0551 0.0954
Echinococcus multilocularis transfer RNA-Gly 0.0021 0.0042 0.0042
Loa Loa (eye worm) latrophilin receptor protein 2 0.01 0.0334 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Mycobacterium ulcerans hypothetical protein 0.0023 0.0049 0.0206
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0216 0.0761 0.1243
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0006
Echinococcus multilocularis lamin 0.0089 0.0293 0.0293
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0025 0.0056 0.0063
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0049 0.0145 0.0145
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0033 0.0033
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0028 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.016 0.0555 0.0625
Schistosoma mansoni rab6-interacting 0.0019 0.0033 0.0033
Echinococcus granulosus hyperpolarization activated cyclic 0.0025 0.0056 0.0056
Schistosoma mansoni loxhd1 0.0019 0.0033 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0144 0.1839
Echinococcus multilocularis musashi 0.0089 0.0293 0.0293
Brugia malayi cation channel family protein 0.0021 0.0042 0.0072
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.002 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0171 0.0171
Trypanosoma cruzi trypanothione reductase, putative 0.0028 0.0066 0.0105
Schistosoma mansoni calcium-activated potassium channel 0.1011 0.3699 0.3699
Toxoplasma gondii ion channel protein 0.0049 0.0145 0.185
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0023 0.023
Echinococcus multilocularis two pore calcium channel protein 1 0.0021 0.0042 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0145 0.0242
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0049 0.0206
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0159 0.0551 0.2897
Schistosoma mansoni 60S ribosomal protein L21 0.0021 0.0042 0.0042
Brugia malayi jmjC domain containing protein 0.0015 0.002 0.0035
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0011 0.0006 0.0006
Trichomonas vaginalis glutathione reductase, putative 0.0028 0.0066 0.0105
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0006 0.0006
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0144 0.0738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0049 0.0144 0.0241
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0021 0.0042 0.0042
Trypanosoma brucei trypanothione reductase 0.008 0.026 0.1354
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.0006 0.0006
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0021 0.0042 0.0042
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0066 0.5
Echinococcus multilocularis serine protein kinase ATM 0.0049 0.0144 0.0144
Mycobacterium ulcerans ion transport protein 0.0049 0.0145 0.1113
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0048 0.014 0.0158
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0028 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1571 0.577 1
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0042 0.0042
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0025 0.0056 0.0056
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0183 0.0641 0.5821
Onchocerca volvulus 0.0049 0.0145 0.0755
Plasmodium falciparum potassium channel 0.0049 0.0145 0.185
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Schistosoma mansoni transient receptor potential channel 0.0021 0.0042 0.0042
Loa Loa (eye worm) TWK-28 protein 0.0049 0.0145 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Echinococcus multilocularis mitogen activated protein kinase 11 0.0159 0.0551 0.0551
Entamoeba histolytica hypothetical protein 0.0041 0.0116 0.0116
Giardia lamblia Kinase, PLK 0.011 0.0368 0.1245
Plasmodium falciparum thioredoxin reductase 0.0028 0.0066 0.0802
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0025 0.0056 0.0056
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0809 0.2954 0.512
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0021 0.0042 0.0216
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.002 0.0025
Schistosoma mansoni hypothetical protein 0.0021 0.0042 0.0042
Echinococcus granulosus TRP transient receptor potential channel 0.0021 0.0042 0.0042
Schistosoma mansoni lipoxygenase 0.0019 0.0033 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0024 0.0011
Echinococcus granulosus lamin dm0 0.0089 0.0293 0.0293
Echinococcus multilocularis Zinc finger, PHD finger 0.0216 0.0761 0.0761
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0144 0.025
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0021 0.0042 0.0475
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Echinococcus multilocularis short transient receptor potential channel 6 0.0022 0.0044 0.0044
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0021 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0025 0.0056 0.0056
Echinococcus multilocularis voltage dependent calcium channel 0.0021 0.0042 0.0042
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0023 0.003
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0216 0.0761 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0025 0.0056 0.0056
Toxoplasma gondii transporter, cation channel family protein 0.0021 0.0042 0.0475
Entamoeba histolytica hypothetical protein 0.0049 0.0144 0.0166
Schistosoma mansoni calcium-activated potassium channel 0.0021 0.0042 0.0042
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0049 0.0206
Onchocerca volvulus 0.0049 0.0145 0.0755
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0042 0.0042
Brugia malayi Transient-receptor-potential like protein 0.0021 0.0042 0.0072
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0144 0.0918
Leishmania major phosphatidylinositol 4-kinase, putative 0.0049 0.0144 0.1839
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0049 0.0145 0.0242
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0066 0.0105
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0049 0.0144 0.0241
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0056
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0006 0.0006
Echinococcus multilocularis lamin dm0 0.0089 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.0006 0.001
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0049 0.0144 0.0144
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.0006 0.001
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0171 0.0171
Echinococcus multilocularis GPCR, family 2 0.01 0.0334 0.0334
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0053 0.016 0.0267
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0049 0.0144 0.0144
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0203 0.0715 0.0715
Onchocerca volvulus 0.0049 0.0145 0.0755
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0368 0.0629
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0066 0.0802
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0028 0.0066 0.0802
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0028 0.0066 0.0802
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.002 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0809 0.2954 0.5115
Loa Loa (eye worm) phosphatidylinositol kinase 0.0049 0.0144 0.0163
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0042 0.0042
Trypanosoma brucei polo-like protein kinase 0.011 0.0368 0.1927
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0368 0.0629
Schistosoma mansoni voltage-gated cation channel 0.0021 0.0042 0.0042
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0042 0.0042
Schistosoma mansoni twik family of potassium channels-related 0.0049 0.0145 0.0145
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.002 0.0025
Echinococcus granulosus GPCR family 2 0.01 0.0334 0.0334
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0049 0.0144 0.1839
Brugia malayi Intermediate filament tail domain containing protein 0.0089 0.0293 0.0509
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0042 0.0042
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0171 0.0569
Onchocerca volvulus Serine\/threonine kinase homolog 0.011 0.0368 0.1911
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0049 0.0144 0.0144
Mycobacterium ulcerans transmembrane cation transporter 0.0049 0.0145 0.1113
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0144 0.0738
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0049 0.0144 0.0144
Trypanosoma brucei protein kinase, putative 0.0056 0.0171 0.0881
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0049 0.0144 0.0738
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0028 0.0066 0.0322
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0164
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0158 0.0158
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0066 0.0802
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0011 0.0006 0.001
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0033 0.0033
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.0006 0.001
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0049 0.0145 0.185
Onchocerca volvulus 0.0019 0.0033 0.017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Echinococcus granulosus voltage dependent calcium channel 0.0021 0.0042 0.0042
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0028 0.0066 0.0364
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0171 0.0288
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.056 0.2032 0.3514
Toxoplasma gondii FATC domain-containing protein 0.0049 0.0144 0.1839
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0049 0.0145 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0144 0.0241
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0049 0.0144 0.0738
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0042 0.0042
Echinococcus granulosus potassium large conductance calcium activated 0.0021 0.0042 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0177 0.02
Echinococcus multilocularis potassium channel subfamily K 8 0.0049 0.0145 0.0145
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0049 0.0144 0.0144
Trypanosoma cruzi ion transport protein, putative 0.0049 0.0145 0.0242
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0049 0.0145 0.0164
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0303 0.1085 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.067 0.067
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0203 0.0715 0.0715
Brugia malayi jmjC domain containing protein 0.0058 0.0177 0.0307
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0683 0.2487 0.4261
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0066 0.0105
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0216 0.0761 0.0761
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0021 0.0042 0.0062
Schistosoma mansoni hypothetical protein 0.0344 0.1235 0.1235
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0021 0.0042 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1926 0.3331
Trichomonas vaginalis glucosylceramidase, putative 0.0809 0.2954 0.5115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.067 0.067
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0049 0.0145 0.1152
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0021 0.0042 0.0042
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0049 0.0581
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0049 0.0144 0.0241
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0049 0.0144 0.1839

Activities

Activity type Activity value Assay description Source Reference
CCIC50 (ADMET) > 100 uM Cytotoxicity was determined against uninfected MT-4 cells ChEMBL. 9484509
EC50 (functional) = 0.34 uM Effective concentration required for the inhibition of HIV-1 IIIB in MT-4 cells ChEMBL. 9484509
Inhibition (binding) = 76 % Inhibition of purified recombinant HIV-1 protease at 0.5 nm using a fluorogenic substrate ChEMBL. 9484509
Inhibition (binding) = 76 % Inhibition of purified recombinant HIV-1 protease at 0.5 nm using a fluorogenic substrate ChEMBL. 9484509
S = 1.2 ug ml-1 Solubility (buffer pH 7.4) ChEMBL. 9484509
S = 91 ug ml-1 Solubility (buffer pH 4) ChEMBL. 9484509

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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