Detailed information for compound 27927

Basic information

Technical information
  • TDR Targets ID: 27927
  • Name: benzyl 4-(4-formyl-1,3-thiazolidine-3-carbony l)-1,3-thiazolidine-3-carboxylate
  • MW: 366.455 | Formula: C16H18N2O4S2
  • H donors: 0 H acceptors: 3 LogP: 1.79 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CC1CSCN1C(=O)C1CSCN1C(=O)OCc1ccccc1
  • InChi: 1S/C16H18N2O4S2/c19-6-13-8-23-10-17(13)15(20)14-9-24-11-18(14)16(21)22-7-12-4-2-1-3-5-12/h1-6,13-14H,7-11H2
  • InChiKey: PXOOURXXVOQWQK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzyl 4-(4-formylthiazolidine-3-carbonyl)thiazolidine-3-carboxylate
  • 4-[(4-formyl-3-thiazolidinyl)-oxomethyl]-3-thiazolidinecarboxylic acid benzyl ester
  • phenylmethyl 4-[(4-methanoyl-1,3-thiazolidin-3-yl)carbonyl]-1,3-thiazolidine-3-carboxylate
  • 4-(4-formylthiazolidine-3-carbonyl)thiazolidine-3-carboxylic acid benzyl ester
  • 3-Thiazolidinecarboxylic acid, 4-[(4-formyl-3-thiazolidinyl)carbonyl]-, phenylmethyl ester
  • AIDS-338640
  • AIDS338640

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prolyl endopeptidase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma japonicum ko:K01322 prolyl oligopeptidase [EC3.4.21.26], putative Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma cruzi prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania infantum prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Neospora caninum Prolyl oligopeptidase (EC 3.4.21.26) (Precursor), related Get druggable targets OG5_129295 All targets in OG5_129295
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129295 All targets in OG5_129295
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_129295 All targets in OG5_129295
Echinococcus multilocularis prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma japonicum Prolyl endopeptidase, putative Get druggable targets OG5_129295 All targets in OG5_129295
Onchocerca volvulus Prolyl endopeptidase homolog Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma congolense prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma brucei gambiense prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania mexicana prolyl oligopeptidase, putative Get druggable targets OG5_129295 All targets in OG5_129295
Echinococcus granulosus prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma brucei prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma mansoni prolyl oligopeptidase (S09 family) Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania donovani prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma mansoni prolyl oligopeptidase (S09 family) Get druggable targets OG5_129295 All targets in OG5_129295
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei oligopeptidase b prolyl endopeptidase 710 aa 630 aa 27.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0129 0.0269
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0535 0.1511
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0317 0.0879
Brugia malayi follicle stimulating hormone receptor 0.0302 0.2191 0.218
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0193 0.0179
Echinococcus granulosus peptide allatostatin:somatostatin 0.0051 0.0317 0.0879
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0317 0.0879
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.008 0.0535 0.0522
Trypanosoma brucei protein kinase, putative 0.0056 0.0352 0.1144
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0063 0.0407 0.1361
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0535 0.1511
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0055 0.0119
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0065 0.0422 0.1182
Echinococcus granulosus sex peptide receptor 0.0051 0.0317 0.0879
Onchocerca volvulus 0.0051 0.0317 0.077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0317 0.0879
Schistosoma mansoni neuropeptide receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) prolyl oligopeptidase 0.0017 0.0061 0.0061
Echinococcus multilocularis somatostatin receptor 0.0051 0.0317 0.0879
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Brugia malayi tailless protein 0.0031 0.0166 0.0152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0422 0.1182
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0065 0.0422 0.0409
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0352 1
Schistosoma mansoni histamine h1 receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0065 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Brugia malayi hypothetical protein 0.0051 0.0317 0.0304
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0063 0.0407 1
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0317 0.0879
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0034 0.0193 0.0519
Echinococcus granulosus alpha 1A adrenergic receptor 0.0051 0.0317 0.0879
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.0422 0.0409
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0357 0.2604 0.2593
Brugia malayi hypothetical protein 0.0031 0.0166 0.0152
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Brugia malayi hypothetical protein 0.0051 0.0317 0.0304
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0317 0.0879
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0352 0.1144
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0422 0.0409
Loa Loa (eye worm) hypothetical protein 0.0034 0.0193 0.0193
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0051 0.0317 0.0879
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0352 0.0978
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0317 0.0879
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0017 0.0061 0.0135
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0535 0.1511
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0051 0.0317 0.0879
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0317 0.0879
Brugia malayi cytochrome P450 0.0017 0.0065 0.0052
Plasmodium falciparum amino acid transporter, putative 0.008 0.0535 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0065 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0182 0.13 0.13
Echinococcus granulosus nuclear receptor nhr 48 0.0031 0.0166 0.0439
Onchocerca volvulus Bile acid receptor homolog 0.0065 0.0422 0.1077
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0158 0.1119 0.3201
Echinococcus granulosus neuropeptide receptor A26 0.0051 0.0317 0.0879
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0166 0.0439
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0166 0.0439
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0061 0.0135
Loa Loa (eye worm) norepinephrine transporter 0.0472 0.3465 0.3465
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0317 0.0317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0317 0.0879
Schistosoma mansoni hypothetical protein 0.0051 0.0317 0.0879
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Schistosoma mansoni hypothetical protein 0.0051 0.0317 0.0879
Loa Loa (eye worm) prolyl oligopeptidase 0.0017 0.0061 0.0061
Brugia malayi nuclear hormone receptor 0.0031 0.0166 0.0152
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Brugia malayi hypothetical protein 0.0034 0.0193 0.0179
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0535 0.0535
Brugia malayi nuclear hormone receptor family member odr-7 0.0031 0.0166 0.0152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0031 0.0166 0.0166
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0535 0.1511
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0535 0.1511
Loa Loa (eye worm) hypothetical protein 0.008 0.0535 0.0535
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0543 0.1533
Onchocerca volvulus 0.0472 0.3465 1
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0352 0.0978
Leishmania major oligopeptidase b 0.0063 0.0407 0.1361
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0535 0.1511
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0166 0.0439
Onchocerca volvulus 0.0031 0.0166 0.0324
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0317 0.0317
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.008 0.0535 0.1511
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0065 0.0422 0.0422
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0317 0.0879
Treponema pallidum sodium- and chloride- dependent transporter 0.0472 0.3465 0.5
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0063 0.0407 0.1361
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0352 1
Onchocerca volvulus 0.0051 0.0317 0.077
Brugia malayi G protein-coupled receptor 0.0051 0.0317 0.0304
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.008 0.0535 0.1511
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0352 0.1144
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0186 0.4316
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Echinococcus granulosus somatostatin receptor 0.0051 0.0317 0.0879
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Schistosoma mansoni biogenic amine receptor 0.0051 0.0317 0.0879
Brugia malayi Dopamine receptor protein 2 0.0051 0.0317 0.0304
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0031 0.0166 0.0439
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0352 0.1144
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0034 0.0193 0.0519
Trypanosoma brucei prolyl oligopeptidase, putative 0.0063 0.0407 0.1361
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0055 0.0119
Brugia malayi Cytochrome P450 family protein 0.0026 0.0129 0.0115
Loa Loa (eye worm) hypothetical protein 0.0065 0.0422 0.0422
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0065 0.0422 0.1182
Onchocerca volvulus Prolyl endopeptidase homolog 0.0158 0.1119 0.312
Onchocerca volvulus 0.0051 0.0317 0.077
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0228 0.0621
Loa Loa (eye worm) hypothetical protein 0.0034 0.0193 0.0193
Brugia malayi G protein-coupled receptor F59B2.13 0.0051 0.0317 0.0304
Onchocerca volvulus 0.0051 0.0317 0.077
Trypanosoma cruzi oligopeptidase b 0.0063 0.0407 0.1361
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.008 0.0535 0.0535
Onchocerca volvulus 0.0051 0.0317 0.077
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0017 0.0061 0.0016
Echinococcus multilocularis dro:myosuppressin receptor 0.0051 0.0317 0.0879
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Echinococcus multilocularis FTZ F1 alpha 0.0065 0.0422 0.1182
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0065 0.0047
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0061 0.0047
Echinococcus multilocularis allatostatin A receptor 0.0051 0.0317 0.0879
Brugia malayi Serotonin receptor 0.0051 0.0317 0.0304
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0055 0.0119
Loa Loa (eye worm) hypothetical protein 0.0065 0.0422 0.0422
Schistosoma mansoni opsin-like receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0034 0.0193 0.0193
Schistosoma mansoni opsin-like receptor 0.0051 0.0317 0.0879
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0063 0.0407 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0065 0.0422 0.1182
Onchocerca volvulus 0.0051 0.0317 0.077
Echinococcus granulosus prolyl endopeptidase 0.0158 0.1119 0.3201
Brugia malayi neuropeptide F receptor 0.0051 0.0317 0.0304
Leishmania major cytochrome p450-like protein 0.0017 0.0065 0.0019
Echinococcus multilocularis acylamino acid releasing enzyme 0.0017 0.0061 0.0135
Echinococcus granulosus death domain containing protein 0.0016 0.0055 0.0119
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0065 0.0422 0.1182
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0055 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0065 0.0422 0.0409
Onchocerca volvulus 0.0065 0.0422 0.1077
Loa Loa (eye worm) hypothetical protein 0.0158 0.1119 0.1119
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 0.0317 0.0879
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0065 0.0019
Loa Loa (eye worm) nuclear hormone receptor 0.0031 0.0166 0.0166
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0472 0.3465 0.3456
Loa Loa (eye worm) hypothetical protein 0.008 0.0535 0.0535
Schistosoma mansoni nuclear receptor nhr-48 0.0031 0.0166 0.0439
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0031 0.0166 0.0152
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0051 0.0317 0.0879
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0051 0.0317 0.0879
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0317 0.0879
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0017 0.0061 0.0135
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Brugia malayi hypothetical protein 0.0051 0.0317 0.0304
Brugia malayi GnHR receptor homolog 0.0051 0.0317 0.0304
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) cytochrome P450 0.0017 0.0065 0.0065
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0051 0.0317 0.0879
Onchocerca volvulus 0.0051 0.0317 0.077
Echinococcus granulosus neuropeptide s receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0317 0.0317
Toxoplasma gondii hypothetical protein 0.008 0.0535 0.4489
Brugia malayi ecdysone receptor 0.0031 0.0166 0.0152
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0051 0.0317 0.077
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0065 0.0422 0.1182
Schistosoma mansoni hypothetical protein 0.0017 0.0065 0.0149
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Plasmodium falciparum transporter, putative 0.008 0.0535 1
Onchocerca volvulus 0.008 0.0535 0.1409
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0166 0.0439
Brugia malayi orphan nuclear receptor NR2E1 0.0031 0.0166 0.0152
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0017 0.0061 0.0135
Brugia malayi prolyl oligopeptidase family protein 0.0158 0.1119 0.1106
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0063 0.0407 0.1361
Onchocerca volvulus Protein ultraspiracle homolog 0.0065 0.0422 0.1077
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0065 0.0422 0.1182
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0017 0.0061 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0051 0.0317 0.0879
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0034 0.0193 0.0193
Toxoplasma gondii prolyl endopeptidase 0.0158 0.1119 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0302 0.2191 0.2191
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0017 0.0061 0.0135
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Leishmania major cytochrome p450-like protein 0.0017 0.0065 0.0019
Brugia malayi photoreceptor-specific nuclear receptor 0.0065 0.0422 0.0409
Schistosoma mansoni cytochrome P450 0.0017 0.0065 0.0149
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.008 0.0535 0.1511
Loa Loa (eye worm) hypothetical protein 0.0016 0.0055 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0061 0.000000026989
Toxoplasma gondii hypothetical protein 0.008 0.0535 0.4489
Schistosoma mansoni sodium-dependent amino acid transporter 0.008 0.0535 0.1511
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0065 0.0422 0.1182
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Brugia malayi Dopamine receptor 0.0051 0.0317 0.0304
Onchocerca volvulus 0.0051 0.0317 0.077
Onchocerca volvulus 0.0031 0.0166 0.0324
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0065 0.0422 0.1182
Echinococcus multilocularis g-protein coupled receptor 0.0051 0.0317 0.0879
Schistosoma mansoni amine GPCR 0.0051 0.0317 0.0879
Echinococcus multilocularis thyroid hormone receptor alpha 0.0065 0.0422 0.1182
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0051 0.0317 0.0304
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0051 0.0317 0.0304
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0142 0.0995 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0031 0.0168 0.0168
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) melatonin receptor type 1A 0.0051 0.0317 0.0317
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0158 0.1119 0.3201
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0051 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0317 0.0879
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0065 0.0422 0.0409
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0535 0.1511
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0017 0.0061 0.0135
Entamoeba histolytica prolyl oligopeptidase family protein 0.0017 0.0061 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0065 0.0422 0.1182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0065 0.0422 0.0422
Echinococcus granulosus 7TM GPCR rhodopsin 0.0051 0.0317 0.0879
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0051 0.0317 0.0879
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0317 0.0879
Schistosoma mansoni coup transcription factor 0.0065 0.0422 0.1182
Echinococcus multilocularis neuropeptide s receptor 0.0051 0.0317 0.0879
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0422 0.0409
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Brugia malayi nuclear receptor NHR-67 0.0031 0.0166 0.0152
Onchocerca volvulus 0.008 0.0535 0.1409
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0535 0.0522
Entamoeba histolytica prolyl oligopeptidase family protein 0.0017 0.0061 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0352 0.1144
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0129 0.0129
Onchocerca volvulus 0.0051 0.0317 0.077
Brugia malayi ORL1-like opioid receptor 0.0051 0.0317 0.0304
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0357 0.2604 1
Onchocerca volvulus 0.0051 0.0317 0.077
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0051 0.0317 0.0879
Brugia malayi Protein kinase domain containing protein 0.0016 0.0059 0.0045
Loa Loa (eye worm) solute carrier family 6 member 4 0.0472 0.3465 0.3465
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0317 0.0879
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0065 0.0422 0.0422
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0017 0.0061 0.0135
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0204 0.0204
Brugia malayi AKH receptor 0.0051 0.0317 0.0304
Echinococcus granulosus g protein coupled receptor 0.0051 0.0317 0.0879
Echinococcus granulosus G protein coupled receptor 139 0.0051 0.0317 0.0879
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0031 0.0166 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0065 0.0422 0.0409
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0535 0.1511
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0422 0.1182
Onchocerca volvulus 0.0051 0.0317 0.077
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Brugia malayi Steroid receptor seven-up type 2 0.0065 0.0422 0.0409
Schistosoma mansoni RAR-like nuclear receptor 0.0065 0.0422 0.1182
Brugia malayi sulfakinin receptor protein 0.0051 0.0317 0.0304
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0357 0.2604 0.2604
Onchocerca volvulus 0.0051 0.0317 0.077
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 0.0317 0.0879
Echinococcus multilocularis sex peptide receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) nuclear receptor NHR-67 0.0031 0.0166 0.0166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0065 0.0422 0.0422
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0051 0.0317 0.0879
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0051 0.0317 0.0879
Echinococcus multilocularis ecdysone induced protein 78C 0.0065 0.0422 0.1182
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0129 0.0269
Trypanosoma brucei oligopeptidase b 0.0063 0.0407 0.1361
Schistosoma mansoni sodium/chloride dependent transporter 0.0472 0.3465 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0051 0.0317 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0317 0.0879
Schistosoma mansoni neuropeptide f receptor 76f 0.0051 0.0317 0.0879
Echinococcus multilocularis prolyl endopeptidase 0.0158 0.1119 0.3201
Echinococcus granulosus hypothetical protein 0.0051 0.0317 0.0879
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0055 0.0041
Loa Loa (eye worm) hypothetical protein 0.0065 0.0422 0.0422
Schistosoma mansoni opsin-like receptor 0.0051 0.0317 0.0879
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0166 0.0439
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0543 0.1533
Loa Loa (eye worm) hypothetical protein 0.0472 0.3465 0.3465
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0061 0.0047
Schistosoma mansoni amine GPCR 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0317 0.0879
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0051 0.0317 0.0879
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0056 0.0122
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0166 0.0152
Echinococcus multilocularis nuclear receptor nhr 48 0.0031 0.0166 0.0439
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0352 0.1144
Echinococcus granulosus dro:myosuppressin receptor 0.0051 0.0317 0.0879
Brugia malayi hypothetical protein 0.0051 0.0317 0.0304
Echinococcus granulosus neuropeptide FF receptor 2 0.0051 0.0317 0.0879
Schistosoma mansoni adenoreceptor 0.0051 0.0317 0.0879
Brugia malayi nuclear receptor RXR 0.0031 0.0166 0.0152
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0317 0.0879
Brugia malayi G-protein coupled receptor 0.0051 0.0317 0.0304
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0352 1
Brugia malayi G-protein coupled receptor 0.0051 0.0317 0.0304
Loa Loa (eye worm) hypothetical protein 0.0472 0.3465 0.3465
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0535 0.0522
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Echinococcus granulosus g protein coupled receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0065 0.0422 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0422 0.0409
Schistosoma mansoni biogenic amine receptor 0.0051 0.0317 0.0879
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0352 0.0978
Brugia malayi RE15519p 0.0051 0.0317 0.0304
Loa Loa (eye worm) hypothetical protein 0.1346 1 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0535 0.1511
Loa Loa (eye worm) hypothetical protein 0.0472 0.3465 0.3465
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0166 0.0439
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0535 0.1511
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0317 0.0879
Mycobacterium tuberculosis Probable peptidase 0.0063 0.0407 0.3672
Echinococcus granulosus tachykinin peptides receptor 99D 0.0051 0.0317 0.0879
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.008 0.0535 0.1511
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0065 0.0422 0.1182
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0051 0.0317 0.0304
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0051 0.0317 0.0879
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 0.0317 0.0879
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Echinococcus granulosus orexin receptor type 2 0.0051 0.0317 0.0879
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0065 0.0422 0.0409
Loa Loa (eye worm) serotonin transporter b 0.0472 0.3465 0.3465
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0129 0.186
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0051 0.0317 0.0879
Echinococcus granulosus neuropeptide receptor 0.0051 0.0317 0.0879
Schistosoma mansoni nuclear receptor 0.0031 0.0166 0.0439
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0065 0.0019
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0031 0.0166 0.0439
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0186 0.4316
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Brugia malayi putative neuropeptide receptor 0.0051 0.0317 0.0304
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0352 0.0352
Brugia malayi hypothetical protein 0.0051 0.0317 0.0304
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0061
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Plasmodium vivax amine transporter, putative 0.008 0.0535 1
Brugia malayi hypothetical protein 0.0031 0.0166 0.0152
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Brugia malayi nuclear hormone receptor 0.0065 0.0422 0.0409
Echinococcus granulosus serotonin receptor 0.0051 0.0317 0.0879
Schistosoma mansoni hypothetical protein 0.0051 0.0317 0.0879
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0055 0.0055
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0051 0.0317 0.0879
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0535 0.1511
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Echinococcus multilocularis serotonin receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0051 0.0317 0.0317
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0228 0.0621
Brugia malayi Uncoordinated protein 44 0.0016 0.0055 0.0041
Brugia malayi Cytochrome P450 family protein 0.0054 0.0344 0.033
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Brugia malayi hypothetical protein 0.0051 0.0317 0.0304
Loa Loa (eye worm) hypothetical protein 0.008 0.0535 0.0535
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0204 0.019
Onchocerca volvulus 0.0051 0.0317 0.077
Brugia malayi larval opioid receptor 0.0051 0.0317 0.0304
Echinococcus granulosus g protein coupled receptor 0.0051 0.0317 0.0879
Schistosoma mansoni neuropeptide receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.0061
Brugia malayi MAP kinase sur-1 0.0056 0.0352 0.0338
Brugia malayi hypothetical protein 0.0051 0.0317 0.0304
Brugia malayi hypothetical protein 0.0034 0.0193 0.0179
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0535 0.4489
Brugia malayi nuclear hormone receptor family member nhr-6 0.0031 0.0166 0.0152
Loa Loa (eye worm) hypothetical protein 0.008 0.0535 0.0535
Echinococcus granulosus fmrfamide receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.0061 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0193 0.0519
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.0065 0.0019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0065 0.0422 0.1182
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Schistosoma mansoni amine GPCR 0.0051 0.0317 0.0879
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0317 0.0879
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0065 0.0422 0.1182
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0422 0.1182
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0472 0.3465 1
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0061 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0065 0.0422 0.0409
Brugia malayi Death domain containing protein 0.0016 0.0055 0.0041
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0065 0.0422 0.1182
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0061 0.000000026989
Schistosoma mansoni biogenic amine receptor 0.0051 0.0317 0.0879
Schistosoma mansoni sodium/chloride dependent transporter 0.0081 0.0539 0.1522
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.008 0.0535 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0065 0.0422 0.1077
Brugia malayi Cytochrome P450 family protein 0.0017 0.0065 0.0052
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0166 0.0324
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0017 0.0061 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0204 0.055
Schistosoma mansoni neuropeptide receptor 0.0051 0.0317 0.0879
Echinococcus multilocularis 0.0017 0.0065 0.0149
Trypanosoma cruzi oligopeptidase b 0.0063 0.0407 0.1361
Schistosoma mansoni retinoic acid receptor RXR 0.0065 0.0422 0.1182
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0352 0.1144
Echinococcus multilocularis orexin receptor type 2 0.0051 0.0317 0.0879
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0051 0.0317 0.0317
Echinococcus granulosus allatostatin A receptor 0.0051 0.0317 0.0879
Trypanosoma cruzi prolyl endopeptidase 0.0158 0.1119 0.4161
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0352 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0422 0.1182
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0317 0.0879
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0051 0.0317 0.0879
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0065 0.0019
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Echinococcus granulosus acylamino acid releasing enzyme 0.0017 0.0061 0.0135
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0352 1
Schistosoma mansoni zinc finger protein 0.0031 0.0166 0.0439
Plasmodium vivax hypothetical protein, conserved 0.008 0.0535 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0065 0.0422 0.0422
Trypanosoma brucei C-8 sterol isomerase, putative 0.0357 0.2604 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0034 0.0193 0.0193
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0317 0.0879
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0535 0.1511
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0051 0.0317 0.0879
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0422 0.1182
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0317 0.0879
Brugia malayi nuclear receptor NHR-88 0.0031 0.0166 0.0152
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0352 0.275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0065 0.0422 0.0422
Brugia malayi Serotonin receptor 0.0051 0.0317 0.0304
Echinococcus multilocularis serotonin receptor 0.0051 0.0317 0.0879
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0051 0.0317 0.0304
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Schistosoma mansoni myosin xvIII 0.0051 0.0317 0.0879
Schistosoma mansoni neuropeptide receptor 0.0051 0.0317 0.0879
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0422 0.0409
Brugia malayi hypothetical protein 0.0051 0.0317 0.0304
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0422 0.1182
Brugia malayi hypothetical protein 0.008 0.0535 0.0522
Schistosoma mansoni hypothetical protein 0.0016 0.0055 0.0119
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0065 0.0422 0.1182
Brugia malayi putative neuropeptide receptor NPR1 0.0051 0.0317 0.0304
Echinococcus granulosus neuropeptide receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) hypothetical protein 0.008 0.0535 0.0535
Loa Loa (eye worm) steroid hormone receptor 0.0065 0.0422 0.0422
Schistosoma mansoni growth hormone secretagogue receptor 0.0051 0.0317 0.0879
Echinococcus granulosus Dipeptidyl peptidase 9 0.0017 0.0061 0.0135
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0065 0.0019
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0063 0.0407 0.1361
Loa Loa (eye worm) hypothetical protein 0.0065 0.0422 0.0422
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0535 0.1511
Brugia malayi nuclear receptor NHR-88 0.0065 0.0422 0.0409
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0129 0.0269
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0317 0.0879
Brugia malayi hypothetical protein 0.0051 0.0317 0.0304
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0317 0.0879
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0535 0.1511
Brugia malayi Cytochrome P450 family protein 0.0026 0.0129 0.0115
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0193 0.0179
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0166 0.0324
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0065 0.0422 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0422 0.0409
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0166 0.0439
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0051 0.0317 0.0879
Echinococcus granulosus thyroid hormone receptor alpha 0.0031 0.0166 0.0439
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0317 0.0879
Echinococcus granulosus Ankyrin 0.0016 0.0056 0.0122
Brugia malayi ecdysteroid receptor 0.0065 0.0422 0.0409
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0031 0.0166 0.0439
Schistosoma mansoni hypothetical protein 0.0051 0.0317 0.0879
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0051 0.0317 0.0304
Leishmania major cytochrome p450-like protein 0.0026 0.0129 0.0269
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 0.0317 0.0879
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0352 0.0978
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0317 0.0879
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0317 0.0879
Schistosoma mansoni alpha-1 adrenergic receptor 0.0051 0.0317 0.0879
Echinococcus granulosus serotonin transporter 0.0472 0.3465 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0051 0.0317 0.0879
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0166 0.0152
Brugia malayi steroid hormone receptor 0.0065 0.0422 0.0409
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0204 0.055
Trypanosoma brucei prolyl endopeptidase 0.0158 0.1119 0.4161
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0158 0.1119 0.4161
Brugia malayi Melatonin receptor type 1A 0.0051 0.0317 0.0304
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0065 0.0422 0.1182
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0535 0.0535
Loa Loa (eye worm) TYRA-2 protein 0.0051 0.0317 0.0317
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0317 0.0879
Echinococcus multilocularis serotonin transporter 0.0472 0.3465 1
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0317 0.0879
Schistosoma mansoni amine GPCR 0.0051 0.0317 0.0879
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0034 0.0193 0.0519
Loa Loa (eye worm) hypothetical protein 0.0034 0.0193 0.0193
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0317 0.0879
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0352 0.1144
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0065 0.0422 0.1182
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.008 0.0535 0.1511
Echinococcus multilocularis Ankyrin 0.0016 0.0056 0.0122
Onchocerca volvulus Neuropeptide F receptor homolog 0.0051 0.0317 0.077
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0061 0.0047
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0063 0.0407 0.3672
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0535 0.0522
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0535 0.4489
Schistosoma mansoni nuclear receptor 0.0031 0.0166 0.0439
Onchocerca volvulus 0.0051 0.0317 0.077
Echinococcus granulosus 7tm_1 domain containing protein 0.0051 0.0317 0.0879
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0535 0.1511
Echinococcus multilocularis neuropeptide receptor A26 0.0051 0.0317 0.0879
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0065 0.0422 0.0409
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0317 0.0879
Echinococcus granulosus FTZ F1 alpha 0.0065 0.0422 0.1182
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0422 0.0409
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.008 0.0535 0.0535
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0065 0.0422 0.0422
Schistosoma mansoni steroid hormone receptor ad4bp 0.0065 0.0422 0.1182
Brugia malayi nuclear receptor RXR 0.0034 0.0193 0.0179
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Onchocerca volvulus 0.0051 0.0317 0.077
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0317 0.0879
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0055 0.0119
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0317 0.0879
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0166 0.0439
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0535 0.4489
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0031 0.0166 0.0439
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0317 0.0879
Brugia malayi hypothetical protein 0.0051 0.0317 0.0304
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0051 0.0317 0.0879
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0422 0.1182
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0065 0.0149
Onchocerca volvulus 0.008 0.0535 0.1409
Onchocerca volvulus 0.0051 0.0317 0.077
Echinococcus multilocularis G-protein coupled receptor, putative 0.0051 0.0317 0.0879
Entamoeba histolytica prolyl oligopeptidase family protein 0.0017 0.0061 0.5
Onchocerca volvulus 0.0051 0.0317 0.077
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0352 0.0978
Brugia malayi conserved hypotetical protein 0.0031 0.0166 0.0152
Schistosoma mansoni amine GPCR 0.0051 0.0317 0.0879
Schistosoma mansoni netrin receptor unc5 0.0016 0.0055 0.0119
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0317 0.0879
Brugia malayi neuropeptide F receptor 0.0051 0.0317 0.0304
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0317
Brugia malayi Tachykinin-like peptides receptor 99D 0.0051 0.0317 0.0304
Echinococcus granulosus g-protein coupled receptor 0.0051 0.0317 0.0879
Loa Loa (eye worm) DR-78 0.0031 0.0166 0.0166
Leishmania major C-8 sterol isomerase-like protein 0.0357 0.2604 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0129 0.0129

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.5 nM Compound was evaluated for the inhibition of prolyl endopeptidase (PEP) purified from human peripheral blood mononuclear cells ChEMBL. No reference
IC50 (binding) = 0.5 nM Compound was evaluated for the inhibition of prolyl endopeptidase (PEP) purified from human peripheral blood mononuclear cells ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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