Detailed information for compound 279455

Basic information

Technical information
  • TDR Targets ID: 279455
  • Name: 2-[[1-[2-[[2-[[2-[[2-[[2-amino-5-(diaminometh ylideneamino)pentanoyl]amino]-3-methylbutanoy l]amino]-3-(4-hydroxyphenyl)propanoyl]amino]- 3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl) propanoyl]pyrrolidine-2-carbonyl]amino]-3-met hylpentanoic acid
  • MW: 897.075 | Formula: C43H68N12O9
  • H donors: 11 H acceptors: 10 LogP: -0.99 Rotable bonds: 31
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCC(C(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(CC)C)C(=O)O)Cc1c[nH]cn1)NC(=O)C(Cc1ccc(cc1)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)N)C
  • InChi: 1S/C43H68N12O9/c1-7-24(5)34(40(61)51-31(20-27-21-47-22-49-27)41(62)55-18-10-12-32(55)38(59)54-35(42(63)64)25(6)8-2)53-37(58)30(19-26-13-15-28(56)16-14-26)50-39(60)33(23(3)4)52-36(57)29(44)11-9-17-48-43(45)46/h13-16,21-25,29-35,56H,7-12,17-20,44H2,1-6H3,(H,47,49)(H,50,60)(H,51,61)(H,52,57)(H,53,58)(H,54,59)(H,63,64)(H4,45,46,48)
  • InChiKey: MOLXDYACMRLMMF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[1-[2-[[2-[[2-[[2-[(2-amino-5-guanidino-pentanoyl)amino]-3-methyl-butanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-methyl-pentanoic acid
  • 2-[[[1-[2-[[2-[[2-[[2-[(2-amino-5-guanidino-1-oxopentyl)amino]-3-methyl-1-oxobutyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-3-methyl-1-oxopentyl]amino]-3-(1H-imidazol-5-yl)-1-oxopropyl]-2-pyrrolidinyl]-oxomethyl]amino]-3-methylpentanoic acid
  • 2-[[1-[2-[[2-[[2-[[2-[[2-azanyl-5-[bis(azanyl)methylideneamino]pentanoyl]amino]-3-methyl-butanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]carbonylamino]-3-methyl-pentanoic acid
  • 2-[[1-[2-[[2-[[2-[[2-[(2-amino-5-guanidino-pentanoyl)amino]-3-methyl-butanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methyl-pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]prolyl]amino]-3-methyl-valeric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0055 0.0117 0.2148
Onchocerca volvulus 0.0102 0.0314 0.1218
Brugia malayi hypothetical protein 0.0047 0.0082 0.0316
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Schistosoma mansoni neuropeptide F-like receptor 0.0086 0.0245 0.0245
Brugia malayi Serotonin receptor 0.0086 0.0245 0.0951
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0086 0.0245 0.0951
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0086 0.0245 0.0886
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0175 0.0621 0.5032
Trichomonas vaginalis reverse transcriptases, putative 0.0054 0.0112 0.041
Onchocerca volvulus Ribonuclease H1 homolog 0.0637 0.258 1
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0034 0.0116
Schistosoma mansoni opsin-like receptor 0.0086 0.0245 0.0245
Brugia malayi hypothetical protein 0.0086 0.0245 0.0951
Brugia malayi hypothetical protein 0.0086 0.0245 0.0951
Echinococcus multilocularis g-protein coupled receptor 0.0086 0.0245 0.0886
Onchocerca volvulus 0.0035 0.0029 0.0111
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0054 0.0113 1
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0108 0.0338 0.1289
Onchocerca volvulus 0.0102 0.0314 0.1218
Brugia malayi G-protein coupled receptor 0.0086 0.0245 0.0951
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0113 0.0912
Loa Loa (eye worm) hypothetical protein 0.0036 0.0033 0.027
Brugia malayi hypothetical protein 0.0047 0.0082 0.0316
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0029 0.0006 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0054 0.0113 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0029 0.0029
Brugia malayi hypothetical protein 0.0047 0.0082 0.0316
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0025 0.18
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0029 0.0029
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0086 0.0245 0.1988
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0029 0.0029
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0002 0.0019
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0102 0.0314 0.2547
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0108 0.0338 0.0332
Echinococcus multilocularis transmembrane protease serine 3 0.0035 0.0029 0.0096
Echinococcus granulosus ribonuclease H1 0.0637 0.258 0.9395
Brugia malayi hypothetical protein 0.0086 0.0245 0.0951
Echinococcus multilocularis sex peptide receptor 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0231
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0054 0.0113 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0245 0.0245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0245 0.0245
Brugia malayi hypothetical protein 0.0054 0.0112 0.0432
Schistosoma mansoni adenoreceptor 0.0086 0.0245 0.0245
Onchocerca volvulus Neuropeptide F receptor homolog 0.0086 0.0245 0.0951
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Plasmodium falciparum cysteine repeat modular protein 1 0.0055 0.0117 0.2148
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0054 0.0113 1
Brugia malayi Muscleblind-like protein 0.03 0.115 0.4459
Schistosoma mansoni nAChR subunit 0.0102 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Brugia malayi RE15519p 0.0086 0.0245 0.0951
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0086 0.0245 0.0886
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0102 0.0314 0.0314
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0029 0.0006 0.0068
Echinococcus granulosus g-protein coupled receptor 0.0086 0.0245 0.0886
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0154 0.0535 0.0535
Brugia malayi hypothetical protein 0.0086 0.0245 0.0951
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Echinococcus multilocularis serotonin receptor 0.0086 0.0245 0.0886
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0054 0.0113 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0084 0.0305
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0086 0.0245 0.0886
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0054 0.0113 0.0414
Schistosoma mansoni myosin xvIII 0.0086 0.0245 0.0245
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0054 0.0113 0.0414
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0029 0.0029
Echinococcus granulosus tachykinin peptides receptor 99D 0.0086 0.0245 0.0886
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0086 0.0245 0.1988
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Schistosoma mansoni amine GPCR 0.0086 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0084 0.0327
Brugia malayi hypothetical protein 0.0035 0.0029 0.0111
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0054 0.0112 0.0398
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0029 0.0029
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0086 0.0245 0.0951
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0082 0.0316
Trypanosoma brucei ingi protein (ORF1) 0.0692 0.281 0.2805
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0054 0.0113 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0084 0.1483
Onchocerca volvulus 0.0055 0.0115 0.0446
Schistosoma mansoni hypothetical protein 0.0086 0.0245 0.0245
Onchocerca volvulus 0.0054 0.0112 0.0432
Onchocerca volvulus 0.0086 0.0245 0.0951
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0086 0.0245 0.0245
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0086 0.0245 0.0245
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0175 0.0621 0.0621
Onchocerca volvulus 0.0086 0.0245 0.0951
Schistosoma mansoni nAChR subunit 0.0102 0.0314 0.0314
Schistosoma mansoni acetylcholine receptor subunit beta 0.0047 0.0082 0.0082
Mycobacterium ulcerans hypothetical protein 0.0048 0.0084 0.6655
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.004 0.0052 0.0418
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0932
Brugia malayi hypothetical protein 0.0086 0.0245 0.0951
Loa Loa (eye worm) hypothetical protein 0.0048 0.0084 0.0684
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0025 0.18
Schistosoma mansoni hypothetical protein 0.0165 0.058 0.058
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0086 0.0245 0.0886
Onchocerca volvulus 0.0035 0.0029 0.0111
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0154 0.0535 1
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0052 0.0046
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0029 0.0006 0.0023
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0319 0.1234 0.449
Brugia malayi larval opioid receptor 0.0086 0.0245 0.0951
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0108 0.0338 0.1289
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Echinococcus multilocularis neuropeptide FF receptor 2 0.0086 0.0245 0.0886
Brugia malayi Dopamine receptor protein 2 0.0086 0.0245 0.0951
Brugia malayi ORL1-like opioid receptor 0.0086 0.0245 0.0951
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0319 0.1234 1
Brugia malayi RNase H family protein 0.0637 0.258 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0102 0.0314 0.1137
Loa Loa (eye worm) hypothetical protein 0.0036 0.0033 0.027
Schistosoma mansoni neurotransmitter gated ion channel 0.0055 0.0115 0.0115
Onchocerca volvulus 0.0086 0.0245 0.0951
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.004 0.0052 0.0178
Schistosoma mansoni opsin-like receptor 0.0086 0.0245 0.0245
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0102 0.0314 0.1137
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0102 0.0314 0.0314
Echinococcus multilocularis enteropeptidase 0.0035 0.0029 0.0096
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0086 0.0245 0.0886
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0054 0.0113 1
Schistosoma mansoni nAChR subunit 0.0047 0.0082 0.0082
Echinococcus multilocularis G protein coupled receptor 139 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0108 0.0338 0.1302
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Echinococcus granulosus neuropeptide receptor A26 0.0086 0.0245 0.0886
Entamoeba histolytica hypothetical protein 0.0055 0.0115 0.2062
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0154 0.0535 0.2057
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0086 0.0245 0.0886
Echinococcus multilocularis nAChR subunit 0.0055 0.0115 0.0411
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0029 0.0029
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0086 0.0245 0.0886
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0054 0.0112 0.0398
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0319 0.1234 0.449
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Echinococcus multilocularis nAChR subunit 0.0102 0.0314 0.1137
Echinococcus multilocularis glycine receptor subunit beta 0.0102 0.0314 0.1137
Brugia malayi hypothetical protein 0.0086 0.0245 0.0951
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0025 0.18
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0108 0.0338 0.6295
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0028 0.0092
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0132 0.0132
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0029 0.0029
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0084 0.0305
Onchocerca volvulus 0.0086 0.0245 0.0951
Loa Loa (eye worm) GABA receptor subunit 0.0055 0.0115 0.0932
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.004 0.0052 0.0925
Trichomonas vaginalis ribonuclease H1, putative 0.0637 0.258 1
Onchocerca volvulus 0.0086 0.0245 0.0951
Schistosoma mansoni nAChR subunit 0.0102 0.0314 0.0314
Schistosoma mansoni phosphoglucomutase 0.0637 0.258 0.258
Entamoeba histolytica hypothetical protein 0.0035 0.003 0.045
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0055 0.0117 0.0946
Echinococcus multilocularis ribonuclease H1 0.0637 0.258 0.9395
Echinococcus granulosus neuropeptide Y receptor 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Brugia malayi hypothetical protein 0.0047 0.0082 0.0316
Onchocerca volvulus Putative nachr subunit 0.0319 0.1234 0.4783
Echinococcus multilocularis serotonin receptor 0.0086 0.0245 0.0886
Trypanosoma brucei hypothetical protein, conserved 0.0692 0.281 0.2805
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0054 0.0112 0.0106
Brugia malayi reverse transcriptase 0.0054 0.0112 0.0432
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0033 0.0571
Echinococcus granulosus protein prenyltransferase alpha subunit 0.004 0.0052 0.018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Loa Loa (eye worm) G-protein coupled receptor 0.0086 0.0245 0.1988
Onchocerca volvulus 0.0086 0.0245 0.0951
Brugia malayi hypothetical protein 0.0086 0.0245 0.0951
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0102 0.0314 0.0314
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0154 0.0535 1
Brugia malayi Trypsin-like protease protein 5 0.0035 0.0029 0.0111
Schistosoma mansoni phosphoglucomutase 0.0637 0.258 0.258
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0054 0.0113 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0102 0.0314 0.1137
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0029 0.0029
Brugia malayi hypothetical protein 0.0054 0.0112 0.0432
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0102 0.0314 0.1218
Echinococcus granulosus 7TM GPCR rhodopsin 0.0086 0.0245 0.0886
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0054 0.0113 1
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0108 0.0338 0.1289
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0086 0.0245 0.0886
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0154 0.0535 0.4337
Brugia malayi excitatory GABA receptor EXP-1A 0.0102 0.0314 0.1218
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0078 0.0214 0.3977
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0175 0.0621 0.0621
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0108 0.0338 0.6295
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0086 0.0245 0.0886
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0194 0.0194
Echinococcus granulosus microtubule associated protein 2 0.0677 0.2746 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0054 0.0113 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0319 0.1234 0.449
Trypanosoma cruzi protein farnesyltransferase, putative 0.0108 0.0338 0.1289
Echinococcus granulosus g protein coupled receptor 0.0086 0.0245 0.0886
Giardia lamblia Prenyltransferase 0.0108 0.0338 0.1302
Schistosoma mansoni phosphoglucomutase 0.0637 0.258 0.258
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0047 0.0082 0.0316
Plasmodium vivax geranylgeranyltransferase, putative 0.0029 0.0006 0.0068
Brugia malayi Cation transporter family protein 0.0175 0.0621 0.2407
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0029 0.0029
Brugia malayi Cytochrome P450 family protein 0.0054 0.0113 0.0436
Toxoplasma gondii hypothetical protein 0.0114 0.0366 0.1411
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0084 0.0327
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0029 0.0029
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0102 0.0314 0.1137
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0054 0.0113 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0033 0.027
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0932
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0049 0.0171
Schistosoma mansoni neuropeptide receptor 0.0086 0.0245 0.0245
Giardia lamblia Rab geranylgeranyltransferase 0.004 0.0052 0.0191
Echinococcus granulosus neuropeptides capa receptor 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0086 0.0245 0.1988
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0231
Onchocerca volvulus 0.0047 0.0082 0.0316
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0154 0.0535 0.2057
Onchocerca volvulus 0.0086 0.0245 0.0951
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0102 0.0314 0.1218
Trypanosoma cruzi cytochrome P450, putative 0.0054 0.0113 0.0414
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0047 0.0082 0.0289
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0054 0.0113 0.0414
Onchocerca volvulus 0.0035 0.0029 0.0111
Brugia malayi Trypsin family protein 0.0035 0.0029 0.0111
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0114 0.0366 0.1399
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0108 0.0338 0.1223
Echinococcus granulosus tm gpcr rhodopsin 0.0086 0.0245 0.0886
Echinococcus granulosus hypothetical protein 0.0086 0.0245 0.0886
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0245 0.0245
Entamoeba histolytica hypothetical protein 0.0035 0.003 0.045
Leishmania major ribonuclease H1, putative 0.0637 0.258 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Loa Loa (eye worm) ACC-1 protein 0.0102 0.0314 0.2547
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0932
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0055 0.0115 0.0446
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0117 0.0431
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0054 0.0112 0.0106
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Echinococcus multilocularis geminin 0.0165 0.058 0.2104
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Brugia malayi sulfakinin receptor protein 0.0086 0.0245 0.0951
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0054 0.0112 0.0424
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0054 0.0113 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0054 0.0112 0.0398
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0035 0.0029 0.0029
Echinococcus multilocularis RNA directed DNA polymerase 0.0054 0.0112 0.0398
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0054 0.0112 0.0398
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0084 0.6655
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0275 0.0995
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0102 0.0314 0.1218
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0154 0.0535 0.2075
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0029 0.0029
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0637 0.258 0.5
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0054 0.0112 0.0398
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0084 0.6655
Onchocerca volvulus 0.0086 0.0245 0.0951
Echinococcus multilocularis glycoprotein Antigen 5 0.0035 0.0029 0.0096
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0086 0.0245 0.0951
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0086 0.0245 0.0245
Brugia malayi cytochrome P450 0.0054 0.0113 0.0436
Echinococcus granulosus neuropeptide FF receptor 2 0.0086 0.0245 0.0886
Brugia malayi Zinc knuckle family protein 0.0054 0.0112 0.0432
Treponema pallidum ribonuclease H (rnhA) 0.0637 0.258 0.5
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0054 0.0113 1
Echinococcus granulosus geminin 0.0165 0.058 0.2104
Brugia malayi Cytochrome P450 family protein 0.0054 0.0113 0.0436
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Echinococcus granulosus nAChR subunit 0.0102 0.0314 0.1137
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0102 0.0314 0.1218
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0033 0.5
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0054 0.0113 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0245 0.0245
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0029 0.0006 0.0006
Echinococcus granulosus RNA directed DNA polymerase 0.0054 0.0112 0.0398
Echinococcus multilocularis tissue type plasminogen activator 0.0055 0.0117 0.0417
Trypanosoma cruzi cytochrome P450, putative 0.0054 0.0113 0.0414
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0086 0.0245 0.0886
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0054 0.0113 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0102 0.0314 0.2547
Loa Loa (eye worm) hypothetical protein 0.03 0.115 0.9321
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.003 0.01
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Brugia malayi putative neuropeptide receptor NPR1 0.0086 0.0245 0.0951
Onchocerca volvulus 0.0055 0.0115 0.0446
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0154 0.0535 0.1943
Echinococcus multilocularis cpg binding protein 0.0029 0.0007 0.0016
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.004 0.0052 0.0925
Onchocerca volvulus 0.0175 0.0621 0.2407
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0054 0.0112 0.0424
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0245 0.0245
Onchocerca volvulus 0.0086 0.0245 0.0951
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0231
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0086 0.0245 0.0245
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0102 0.0314 0.1137
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0108 0.0338 0.1309
Onchocerca volvulus 0.0086 0.0245 0.0951
Schistosoma mansoni hypothetical protein 0.0086 0.0245 0.0245
Echinococcus granulosus neuropeptide receptor 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Echinococcus granulosus allatostatin A receptor 0.0086 0.0245 0.0886
Brugia malayi Zinc knuckle family protein 0.0054 0.0112 0.0432
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.1558 0.5671
Echinococcus multilocularis neuropeptides capa receptor 0.0086 0.0245 0.0886
Schistosoma mansoni hypothetical protein 0.0055 0.0117 0.0117
Echinococcus multilocularis neuropeptides capa receptor 0.0086 0.0245 0.0886
Trypanosoma cruzi protein farnesyltransferase, putative 0.0108 0.0338 0.1289
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0029 0.0029
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0054 0.0112 0.0398
Onchocerca volvulus 0.0175 0.0621 0.2407
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0054 0.0112 0.0398
Loa Loa (eye worm) hypothetical protein 0.0319 0.1234 1
Echinococcus granulosus glycoprotein Antigen 5 0.0035 0.0029 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0052 0.0178
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0108 0.0338 0.2737
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.004 0.0052 0.0046
Echinococcus granulosus neuropeptide receptor 0.0086 0.0245 0.0886
Loa Loa (eye worm) neuropeptide F receptor 0.0086 0.0245 0.1988
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0084 0.6655
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.0314 0.1218
Brugia malayi GnHR receptor homolog 0.0086 0.0245 0.0951
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 0.0115 0.0115
Echinococcus granulosus neuropeptide s receptor 0.0086 0.0245 0.0886
Echinococcus multilocularis neuropeptide s receptor 0.0086 0.0245 0.0886
Schistosoma mansoni biogenic amine receptor 0.0086 0.0245 0.0245
Schistosoma mansoni hypothetical protein 0.0165 0.058 0.058
Schistosoma mansoni amine GPCR 0.0086 0.0245 0.0245
Brugia malayi hypothetical protein 0.0054 0.0112 0.0432
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0054 0.0112 0.0398
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0108 0.0338 0.0338
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0084 0.7365
Brugia malayi hypothetical protein 0.0086 0.0245 0.0951
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0084 0.1483
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0108 0.0338 0.1289
Schistosoma mansoni hypothetical protein 0.0054 0.0112 0.0112
Leishmania major farnesyltransferase beta subunit 0.0108 0.0338 0.1289
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0112 0.041
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0029 0.0006 0.0006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0082 0.0316
Echinococcus granulosus alpha 1A adrenergic receptor 0.0086 0.0245 0.0886
Onchocerca volvulus 0.0055 0.0117 0.0453
Schistosoma mansoni cpg binding protein 0.0029 0.0007 0.0007
Brugia malayi Trypsin family protein 0.0035 0.0029 0.0111
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0086 0.0245 0.0951
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0054 0.0113 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.0314 0.1218
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0113 0.0912
Echinococcus granulosus neuropeptides capa receptor 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0035 0.0029 0.0096
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0102 0.0314 0.1137
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0054 0.0112 0.0432
Brugia malayi Bromodomain containing protein 0.0028 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0932
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0029 0.0006 0.0048
Echinococcus granulosus neuropeptide Y receptor 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0028 0.0002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Toxoplasma gondii ribonuclease HI protein 0.0637 0.258 1
Schistosoma mansoni nAChR subunit 0.0102 0.0314 0.0314
Echinococcus multilocularis muscleblind protein 0.03 0.115 0.4184
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0084 0.0327
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.003 0.01
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Schistosoma mansoni nAChR subunit 0.0102 0.0314 0.0314
Echinococcus multilocularis fmrfamide receptor 0.0086 0.0245 0.0886
Loa Loa (eye worm) TK/ROR protein kinase 0.0055 0.0117 0.0946
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0108 0.0338 0.1289
Trypanosoma brucei ribonuclease H1 0.0637 0.258 0.2576
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0154 0.0535 1
Schistosoma mansoni hypothetical protein 0.0028 0.0002 0.0002
Toxoplasma gondii hypothetical protein 0.004 0.0052 0.0191
Giardia lamblia Reverse transcriptase/endonuclease 0.0054 0.0112 0.0424
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Schistosoma mansoni neuropeptide receptor 0.0086 0.0245 0.0245
Brugia malayi Melatonin receptor type 1A 0.0086 0.0245 0.0951
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0086 0.0245 0.0245
Toxoplasma gondii cytochrome p450 superfamily protein 0.0054 0.0113 0.0428
Leishmania major cytochrome p450-like protein 0.0054 0.0113 0.0414
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Schistosoma mansoni hypothetical protein 0.0086 0.0245 0.0245
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0102 0.0314 0.1137
Schistosoma mansoni biogenic amine receptor 0.0086 0.0245 0.0245
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0029 0.0029
Echinococcus granulosus 7tm_1 domain containing protein 0.0086 0.0245 0.0886
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0086 0.0245 0.0886
Brugia malayi neuropeptide F receptor 0.0086 0.0245 0.0951
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0054 0.0112 0.0398
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0086 0.0245 0.0886
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0054 0.0113 1
Brugia malayi Trypsin family protein 0.0035 0.0029 0.0111
Schistosoma mansoni neuropeptide F-like receptor 0.0086 0.0245 0.0245
Brugia malayi Dopamine receptor 0.0086 0.0245 0.0951
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.0314 0.1218
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Onchocerca volvulus 0.0102 0.0314 0.1218
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0102 0.0314 0.1218
Onchocerca volvulus 0.0086 0.0245 0.0951
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Echinococcus granulosus nAChR subunit 0.0055 0.0115 0.0411
Schistosoma mansoni hypothetical protein 0.0035 0.0029 0.0029
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0034 0.0277
Echinococcus granulosus glycine receptor subunit alpha 1 0.0102 0.0314 0.1137
Leishmania major hypothetical protein, conserved 0.0055 0.0117 0.0431
Loa Loa (eye worm) melatonin receptor type 1A 0.0086 0.0245 0.1988
Echinococcus granulosus tissue type plasminogen activator 0.0055 0.0117 0.0417
Loa Loa (eye worm) hypothetical protein 0.0036 0.0033 0.027
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0054 0.0113 0.0107
Onchocerca volvulus 0.0047 0.0082 0.0316
Onchocerca volvulus 0.0175 0.0621 0.2407
Entamoeba histolytica hypothetical protein 0.0035 0.003 0.045
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Brugia malayi Serotonin receptor 0.0086 0.0245 0.0951
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Echinococcus multilocularis g protein coupled receptor 0.0086 0.0245 0.0886
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0029 0.0006 0.0014
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0029 0.0006 0.0068
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0054 0.0113 1
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0033 0.0582
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0047 0.0082 0.0316
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.004 0.0052 0.02
Echinococcus granulosus glycine receptor subunit alpha 1 0.0102 0.0314 0.1137
Onchocerca volvulus 0.0086 0.0245 0.0951
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0055 0.0115 0.0446
Brugia malayi follicle stimulating hormone receptor 0.0086 0.0245 0.0951
Echinococcus granulosus g protein coupled receptor 0.0086 0.0245 0.0886
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0029 0.0029
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0035 0.0029 0.0096
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Brugia malayi AKH receptor 0.0086 0.0245 0.0951
Echinococcus multilocularis g protein coupled receptor 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0029 0.0029
Echinococcus multilocularis fmrfamide receptor 0.0086 0.0245 0.0886
Schistosoma mansoni acetylcholine receptor-related 0.0047 0.0082 0.0082
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0035 0.0029 0.0096
Loa Loa (eye worm) hypothetical protein 0.0036 0.0033 0.027
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0319 0.1234 0.449
Toxoplasma gondii kringle domain-containing protein 0.0055 0.0117 0.0444
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0025 0.18
Onchocerca volvulus 0.0048 0.0084 0.0327
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0054 0.0113 1
Onchocerca volvulus 0.0054 0.0112 0.0432
Schistosoma mansoni protein kinase 0.0054 0.0112 0.0112
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0054 0.0112 0.0398
Schistosoma mansoni neuropeptide receptor 0.0086 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Brugia malayi hypothetical protein 0.0086 0.0245 0.0951
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0082 0.0082
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0102 0.0314 0.1218
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0029 0.0006 0.0013
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0105 0.0399
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0086 0.0245 0.0245
Schistosoma mansoni biogenic amine (5HT) receptor 0.0086 0.0245 0.0245
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0054 0.0112 0.0398
Schistosoma mansoni biogenic amine (5HT) receptor 0.0086 0.0245 0.0245
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0047 0.0082 0.0316
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0054 0.0112 0.0424
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0029 0.0006 0.0014
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0113 0.0912
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.0314 0.1218
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0054 0.0112 0.0398
Trypanosoma cruzi ribonuclease H1, putative 0.0637 0.258 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0054 0.0113 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Brugia malayi Cytochrome P450 family protein 0.0054 0.0113 0.0436
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Brugia malayi G protein-coupled receptor F59B2.13 0.0086 0.0245 0.0951
Leishmania major protein farnesyltransferase alpha subunit, putative 0.004 0.0052 0.0178
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0034 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0054 0.0113 1
Onchocerca volvulus 0.0035 0.0029 0.0111
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.004 0.0052 0.0046
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0275 0.0995
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.004 0.0052 0.018
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0086 0.0245 0.0886
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0054 0.0113 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0054 0.0112 0.041
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0231
Schistosoma mansoni histamine h1 receptor 0.0086 0.0245 0.0245
Trichomonas vaginalis reverse transcriptases, putative 0.0054 0.0112 0.041
Schistosoma mansoni hypothetical protein 0.0054 0.0112 0.0112
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0086 0.0245 0.0951
Loa Loa (eye worm) TYRA-2 protein 0.0086 0.0245 0.1988
Echinococcus multilocularis neuropeptide receptor 0.0086 0.0245 0.0886
Echinococcus multilocularis Mastin 0.0035 0.0029 0.0096
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Schistosoma mansoni hypothetical protein 0.0054 0.0113 0.0113
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0052 0.0052
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0054 0.0113 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0054 0.0113 1
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0054 0.0112 0.041
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0086 0.0245 0.0245
Echinococcus multilocularis G-protein coupled receptor, putative 0.0086 0.0245 0.0886
Echinococcus granulosus cytochrome P450 2K1 0.0054 0.0113 0.0402
Schistosoma mansoni amine GPCR 0.0086 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0932
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Brugia malayi hypothetical protein 0.0035 0.003 0.0115
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0054 0.0112 0.0106
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0086 0.0245 0.0245
Loa Loa (eye worm) ACC-1 protein 0.0102 0.0314 0.2547
Schistosoma mansoni neuropeptide f receptor 76f 0.0086 0.0245 0.0245
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0054 0.0113 1
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0055 0.0115 0.0115
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0231
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0047 0.0082 0.0661
Schistosoma mansoni nAChR subunit 0.0102 0.0314 0.0314
Brugia malayi Cation transporter family protein 0.0102 0.0314 0.1218
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Brugia malayi Trypsin family protein 0.0035 0.0029 0.0111
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0035 0.0029 0.0111
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0086 0.0245 0.0886
Brugia malayi reverse transcriptase 0.0054 0.0112 0.0432
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0054 0.0113 1
Echinococcus multilocularis muscleblind protein 1 0.03 0.115 0.4184
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0108 0.0338 0.1289
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0086 0.0245 0.1988
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0102 0.0314 0.1137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0231
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0035 0.0029 0.0096
Schistosoma mansoni cytochrome P450 0.0054 0.0113 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0054 0.0113 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0932
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Loa Loa (eye worm) acetylcholine receptor protein 0.0047 0.0082 0.0661
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.004 0.0052 0.0178
Brugia malayi reverse transcriptase 0.0054 0.0112 0.0432
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0084 0.0305
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0054 0.0113 1
Onchocerca volvulus 0.0086 0.0245 0.0951
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0102 0.0314 0.1218
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0084 0.7365
Echinococcus granulosus peptide allatostatin:somatostatin 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0086 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0048 0.0084 0.0684
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0932
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.003 0.003
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0029 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Brugia malayi PHD-finger family protein 0.0028 0.0002 0.0009
Giardia lamblia Rab geranylgeranyltransferase 0.0029 0.0006 0.0014
Echinococcus granulosus glycine receptor subunit beta 0.0102 0.0314 0.1137
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0086 0.0245 0.0951
Mycobacterium leprae putative cytochrome p450 0.0054 0.0113 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Echinococcus granulosus muscleblind protein 0.03 0.115 0.4184
Brugia malayi RNase H family protein 0.0637 0.258 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0048
Entamoeba histolytica hypothetical protein 0.0035 0.003 0.045
Schistosoma mansoni opsin-like receptor 0.0086 0.0245 0.0245
Echinococcus granulosus enteropeptidase 0.0035 0.0029 0.0096
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0692 0.281 0.2805
Loa Loa (eye worm) hypothetical protein 0.0055 0.0115 0.0932
Mycobacterium tuberculosis Possible maturase 0.0054 0.0112 0.9905
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0054 0.0113 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0102 0.0314 0.1137
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0102 0.0314 0.1137
Onchocerca volvulus 0.004 0.0052 0.02
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0049 0.0171
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0231
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0054 0.0113 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Schistosoma mansoni alpha-1 adrenergic receptor 0.0086 0.0245 0.0245
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0054 0.0113 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0086 0.0245 0.0886
Echinococcus multilocularis 0.0054 0.0113 0.0402
Echinococcus granulosus Mastin 0.0035 0.0029 0.0096
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0319 0.1234 0.449
Brugia malayi Protein kinase domain containing protein 0.0055 0.0117 0.0453
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Trypanosoma cruzi ribonuclease H1, putative 0.0637 0.258 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0054 0.0113 1
Echinococcus multilocularis glycine receptor subunit beta 0.0102 0.0314 0.1137
Loa Loa (eye worm) trypsin family protein 0.0035 0.0029 0.0231
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Echinococcus granulosus G protein coupled receptor 139 0.0086 0.0245 0.0886
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.013 0.1053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Brugia malayi Cytochrome P450 family protein 0.0054 0.0113 0.0436
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0086 0.0245 0.1988
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0086 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Echinococcus granulosus glycine receptor subunit alpha 1 0.0102 0.0314 0.1137
Echinococcus multilocularis orexin receptor type 2 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Schistosoma mansoni biogenic amine receptor 0.0086 0.0245 0.0245
Onchocerca volvulus 0.0086 0.0245 0.0951
Brugia malayi hypothetical protein 0.0086 0.0245 0.0951
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0033 0.2573
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.0115 0.0446
Loa Loa (eye worm) hypothetical protein 0.0175 0.0621 0.5032
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.004 0.0052 0.018
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0033 0.0582
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0086 0.0245 0.0886
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0086 0.0245 0.0245
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0084 0.6655
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0029 0.0006 0.0006
Giardia lamblia Rab geranylgeranyltransferase 0.0154 0.0535 0.2068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Brugia malayi neuropeptide F receptor 0.0086 0.0245 0.0951
Echinococcus granulosus tm gpcr rhodopsin 0.0086 0.0245 0.0886
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0054 0.0113 1
Brugia malayi G-protein coupled receptor 0.0086 0.0245 0.0951
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0108 0.0338 0.1223
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0084 0.6655
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0047 0.0082 0.0289
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Trypanosoma brucei unspecified product 0.0692 0.281 0.2805
Schistosoma mansoni growth hormone secretagogue receptor 0.0086 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0049 0.0088 0.0713
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0054 0.0113 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.0115 0.0446
Loa Loa (eye worm) hypothetical protein 0.0048 0.0084 0.0684
Echinococcus granulosus transmembrane protease serine 3 0.0035 0.0029 0.0096
Leishmania major cytochrome p450-like protein 0.0054 0.0113 0.0414
Brugia malayi G protein-coupled receptor 0.0086 0.0245 0.0951
Schistosoma mansoni nAChR subunit 0.0047 0.0082 0.0082
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.0314 0.1218
Schistosoma mansoni hypothetical protein 0.0396 0.1558 0.1558
Echinococcus granulosus serotonin receptor 0.0086 0.0245 0.0886
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.2746 0.2746
Plasmodium falciparum geranylgeranyltransferase, putative 0.0029 0.0006 0.0068
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0102 0.0314 0.2547
Onchocerca volvulus Alhambra homolog 0.0028 0.0002 0.0009
Brugia malayi hypothetical protein 0.0047 0.0082 0.0316
Schistosoma mansoni nAChR subunit 0.0102 0.0314 0.0314
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0154 0.0535 0.1943
Schistosoma mansoni neuropeptide receptor 0.0086 0.0245 0.0245
Loa Loa (eye worm) LGC-31 protein 0.0102 0.0314 0.2547
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0047 0.0082 0.0289
Echinococcus multilocularis neuropeptide receptor 0.0086 0.0245 0.0886
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0084 0.6655
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0102 0.0314 0.1137
Echinococcus granulosus g protein coupled receptor 0.0086 0.0245 0.0886
Echinococcus multilocularis somatostatin receptor 0.0086 0.0245 0.0886
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0245 0.0886
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0034 0.0034
Echinococcus granulosus tm gpcr rhodopsin 0.0086 0.0245 0.0886
Echinococcus granulosus fmrfamide receptor 0.0086 0.0245 0.0886
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0084 0.6655
Schistosoma mansoni amine GPCR 0.0086 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Echinococcus multilocularis g protein coupled receptor 0.0086 0.0245 0.0886
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0054 0.0112 0.0112
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0102 0.0314 0.1218
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.2746 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0086 0.0245 0.0951
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.0029 0.0029
Brugia malayi hypothetical protein 0.0054 0.0112 0.0432
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0047 0.0082 0.0289
Onchocerca volvulus 0.0035 0.0029 0.0111
Echinococcus granulosus KRAB A domain containing protein 0.0054 0.0112 0.0398
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0102 0.0314 0.1218
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0108 0.0338 0.627
Loa Loa (eye worm) G-protein coupled receptor 0.0086 0.0245 0.1988
Loa Loa (eye worm) cytochrome P450 0.0054 0.0113 0.0912
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Echinococcus granulosus orexin receptor type 2 0.0086 0.0245 0.0886
Onchocerca volvulus 0.0086 0.0245 0.0951
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0102 0.0314 0.1137
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.004 0.0052 0.0046
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0102 0.0314 0.2547
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Echinococcus granulosus biogenic amine 5HT receptor 0.0086 0.0245 0.0886
Brugia malayi Dopamine receptor protein 1 0.0086 0.0245 0.0951
Brugia malayi putative neuropeptide receptor 0.0086 0.0245 0.0951
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.004 0.0052 0.0178
Echinococcus multilocularis allatostatin A receptor 0.0086 0.0245 0.0886
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0054 0.0112 0.0398
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Brugia malayi Kringle domain containing protein 0.0055 0.0117 0.0453
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0054 0.0113 1
Brugia malayi RNase H family protein 0.0637 0.258 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0319 0.1234 0.4783
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0054 0.0113 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0054 0.0113 1
Echinococcus granulosus sex peptide receptor 0.0086 0.0245 0.0886
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0029 0.0006 0.0013
Echinococcus granulosus glycine receptor subunit beta 0.0102 0.0314 0.1137
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0002 0.0002
Trypanosoma brucei cytochrome P450, putative 0.0054 0.0113 0.0107
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0086 0.0245 0.0886
Loa Loa (eye worm) CYP4Cod1 0.0054 0.0113 0.0912
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0154 0.0535 0.2057
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0086 0.0245 0.0245
Loa Loa (eye worm) neuropeptide F receptor 0.0086 0.0245 0.1988
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0054 0.0113 1
Schistosoma mansoni hypothetical protein 0.0035 0.0029 0.0029
Echinococcus granulosus dro:myosuppressin receptor 0.0086 0.0245 0.0886
Leishmania major cytochrome p450-like protein 0.0054 0.0113 0.0414
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0086 0.0245 0.0245
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0086 0.0245 0.0886
Brugia malayi jmjC domain containing protein 0.0036 0.0034 0.0133
Echinococcus granulosus cpg binding protein 0.0029 0.0007 0.0016
Echinococcus multilocularis neuropeptide Y receptor 0.0086 0.0245 0.0886
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0319 0.1234 0.449
Loa Loa (eye worm) hypothetical protein 0.0127 0.0422 0.3417
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Loa Loa (eye worm) hypothetical protein 0.03 0.115 0.9321
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.004 0.0052 0.018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0084 0.1483
Schistosoma mansoni hypothetical protein 0.0035 0.003 0.003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0102 0.0314 0.1218
Loa Loa (eye worm) hypothetical protein 0.0154 0.0535 0.4337
Onchocerca volvulus 0.0047 0.0082 0.0316
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0052 0.0178
Giardia lamblia Ribonuclease H 0.0637 0.258 1
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0054 0.0112 0.0424
Loa Loa (eye worm) hypothetical protein 0.0102 0.0314 0.2547
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0102 0.0314 0.0314
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0082 0.0316
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.004 0.0052 0.0178
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0054 0.0112 0.0398
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0054 0.0113 1
Echinococcus granulosus dnaJ subfamily B 0.0396 0.1558 0.5671
Onchocerca volvulus 0.0086 0.0245 0.0951
Schistosoma mansoni cpg binding protein 0.0029 0.0007 0.0007
Echinococcus multilocularis dro:myosuppressin receptor 0.0086 0.0245 0.0886
Trypanosoma brucei ingi protein (ORF1) 0.0692 0.281 0.2805
Brugia malayi Pao retrotransposon peptidase family protein 0.0054 0.0112 0.0432
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0054 0.0113 1
Trypanosoma brucei RNA helicase, putative 0.239 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0054 0.0113 1
Onchocerca volvulus 0.0086 0.0245 0.0951
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.004 0.0052 0.0864
Brugia malayi jmjC domain containing protein 0.0093 0.0275 0.1067
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0047 0.0082 0.0661
Schistosoma mansoni amine GPCR 0.0086 0.0245 0.0245
Echinococcus multilocularis neuropeptide receptor A26 0.0086 0.0245 0.0886
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0047 0.0082 0.0289
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0054 0.0113 0.0414
Brugia malayi Cation transporter family protein 0.0102 0.0314 0.1218
Echinococcus granulosus somatostatin receptor 0.0086 0.0245 0.0886
Schistosoma mansoni hypothetical protein 0.0086 0.0245 0.0245
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0054 0.0113 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.0661
Loa Loa (eye worm) hypothetical protein 0.0086 0.0245 0.1988
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0102 0.0314 0.2547
Onchocerca volvulus 0.0035 0.0029 0.0111
Echinococcus multilocularis neuropeptide Y receptor 0.0086 0.0245 0.0886

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 % In vitro agonist angiotensin II like activity was measured in the rabbit aorta strip assay ChEMBL. 3351849
BP increase (functional) = 5 mmHg In vivo agonist angiotensin II like activity was measured in rat blood pressure increase by a 1 ug iv injection ChEMBL. 3351849
ID50 (functional) = 200 ng min-1 rat-1 Antagonist activity ID50 was measured in vivo in the rat blood pressure assay ChEMBL. 3351849
pA2 (functional) = 7.75 In vitro antagonist activity against Angiotensin II receptor was measured in the rabbit aorta strip assay ChEMBL. 3351849

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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