Detailed information for compound 279766

Basic information

Technical information
  • TDR Targets ID: 279766
  • Name: N-[(7S)-10-tert-butyl-1,2,3-trimethoxy-9-oxo- 6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamid e
  • MW: 425.517 | Formula: C25H31NO5
  • H donors: 1 H acceptors: 2 LogP: 3.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c2c(CC[C@@H](c3c2ccc(c(=O)c3)C(C)(C)C)NC(=O)C)cc(c1OC)OC
  • InChi: 1S/C25H31NO5/c1-14(27)26-19-11-8-15-12-21(29-5)23(30-6)24(31-7)22(15)16-9-10-18(25(2,3)4)20(28)13-17(16)19/h9-10,12-13,19H,8,11H2,1-7H3,(H,26,27)/t19-/m0/s1
  • InChiKey: OECPDGWFTNVUEY-IBGZPJMESA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(7S)-10-tert-butyl-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]ethanamide
  • N-[(7S)-10-tert-butyl-9-keto-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
  • N-[(7S)-10-tert-butyl-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]acetamide
  • N-[(7S)-10-tert-butyl-9-keto-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[d]heptalen-7-yl]acetamide
  • N-[(7S)-10-tert-butyl-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum telomerase reverse transcriptase 0.0977 0.271 1
Schistosoma mansoni flap endonuclease-1 0.006 0.014 0.0689
Echinococcus granulosus dna polymerase kappa 0.0096 0.0239 0.0475
Onchocerca volvulus 0.0653 0.1803 0.1803
Trichomonas vaginalis flap endonuclease-1, putative 0.0067 0.0158 0.242
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0022 0.0032 0.0089
Giardia lamblia DNA damage repair protein 0.0023 0.0036 0.0102
Loa Loa (eye worm) RNA binding protein 0.0049 0.0107 0.0324
Leishmania major DNA polymerase eta, putative 0.0095 0.0237 0.0845
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0085 0.0282
Brugia malayi Matrixin family protein 0.1173 0.326 0.449
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0014 0.0025
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0009 0.0018
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.052 0.1427 0.7039
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0046 0.01 0.0368
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0075 0.0182 0.055
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0096 0.0239 0.3699
Schistosoma mansoni hypothetical protein 0.0734 0.2028 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0022 0.0032 0.0094
Schistosoma mansoni DNA helicase recq1 0.0041 0.0085 0.0418
Mycobacterium tuberculosis Conserved hypothetical protein 0.0075 0.0182 0.0995
Schistosoma mansoni hypothetical protein 0.0273 0.0737 0.3633
Schistosoma mansoni smad1 5 8 and 0.0021 0.0029 0.0143
Brugia malayi glutaminase DH11.1 0.0239 0.0641 0.0883
Schistosoma mansoni DNA helicase recq5 0.0041 0.0085 0.0418
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0088 0.0436
Entamoeba histolytica hypothetical protein 0.002 0.0028 0.0079
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0096
Trichomonas vaginalis glutaminase, putative 0.0239 0.0641 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.005 0.011 0.0219
Trypanosoma cruzi polo-like protein kinase, putative 0.0087 0.0214 0.076
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0096
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0084 0.0206 0.0284
Trichomonas vaginalis DNA helicase recq, putative 0.0047 0.0103 0.1566
Brugia malayi Matrixin family protein 0.052 0.1427 0.1966
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0014 0.0009 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0088 0.0176
Brugia malayi Associated with TFs and helicases family protein 0.0021 0.0029 0.004
Echinococcus multilocularis BRK domain containing protein 0.0021 0.0029 0.0058
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0067 0.0158 0.0552
Echinococcus multilocularis microtubule associated protein 2 0.0634 0.1748 0.3473
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0239 0.0854
Loa Loa (eye worm) hypothetical protein 0.0633 0.1745 0.5272
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0041 0.0121
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.004 0.0055
Brugia malayi Disintegrin family protein 0.0056 0.0129 0.0178
Echinococcus multilocularis flap endonuclease 1 0.0067 0.0158 0.0313
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0239 0.0854
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0087 0.0214 0.0425
Toxoplasma gondii HEAT repeat-containing protein 0.0025 0.0041 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0239 0.0854
Schistosoma mansoni hypothetical protein 0.0059 0.0136 0.0673
Echinococcus granulosus bloom syndrome protein 0.0073 0.0174 0.0346
Onchocerca volvulus 0.0407 0.1112 0.1112
Loa Loa (eye worm) MBCTL1 0.005 0.011 0.0334
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0026 0.0044 0.0088
Schistosoma mansoni ap endonuclease 0.0034 0.0065 0.0321
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0028 0.0386
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0045 0.009
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0021 0.0029 0.0058
Loa Loa (eye worm) Smad1 0.0021 0.0029 0.0088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0032 0.0129
Echinococcus granulosus endonuclease exonuclease phosphatase 0.018 0.0474 0.0942
Mycobacterium leprae PROBABLE HYDROLASE 0.0633 0.1745 1
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0268 0.0721 0.3555
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0091 0.1375
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0356 0.0968 0.1922
Schistosoma mansoni smad1 5 8 and 0.0021 0.0029 0.0143
Onchocerca volvulus 0.0025 0.004 0.004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0085 0.0282
Toxoplasma gondii DNA methyltransferase 2, putative 0.0017 0.0019 0.0039
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.005 0.011 0.0219
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0018 0.0035
Onchocerca volvulus 0.0025 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.1191 0.331 1
Brugia malayi exodeoxyribonuclease III family protein 0.0034 0.0065 0.009
Leishmania major modification methylase-like protein 0.0017 0.0019 0.0039
Echinococcus granulosus disco interacting protein 2 0.0035 0.0068 0.0134
Schistosoma mansoni lamin 0.0025 0.004 0.0198
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0125 0.0321 0.1157
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0036 0.0134
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0036 0.0134
Loa Loa (eye worm) hypothetical protein 0.0268 0.0722 0.2181
Brugia malayi RNA, U transporter 1 0.0072 0.0172 0.0237
Brugia malayi ADAMTS-like protease 0.0042 0.0088 0.0122
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.004 0.0121
Echinococcus multilocularis global transcription activator snf2l2 0.012 0.0308 0.0613
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0085 0.0117
Brugia malayi ImpB/MucB/SamB family protein 0.0095 0.0237 0.0326
Brugia malayi Matrixin family protein 0.052 0.1427 0.1966
Brugia malayi angiogenesis inhibito 0.0042 0.0088 0.0122
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0014 0.0009 0.0043
Loa Loa (eye worm) hypothetical protein 0.0044 0.0094 0.0282
Entamoeba histolytica recQ family DNA helicase 0.0021 0.0029 0.0082
Loa Loa (eye worm) RecQ helicase 0.0073 0.0174 0.0527
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0017 0.0024
Trichomonas vaginalis DNA helicase recq1, putative 0.0073 0.0174 0.268
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0028 0.0386
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0044 0.0093 0.0093
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.0239 0.129
Schistosoma mansoni terminal deoxycytidyl transferase 0.0075 0.0182 0.0898
Schistosoma mansoni hypothetical protein 0.0021 0.0029 0.0143
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0036 0.0102
Echinococcus granulosus mothers against decapentaplegic 5 0.0021 0.0029 0.0058
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0022 0.0032 0.0089
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0121
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.008 0.0196 0.0694
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0034 0.0065 0.0209
Plasmodium vivax telomerase reverse transcriptase, putative 0.0977 0.271 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0096 0.0239 0.3699
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0264 0.0712 0.2602
Schistosoma mansoni importin beta-1 0.0025 0.0041 0.0204
Schistosoma mansoni hypothetical protein 0.0027 0.0045 0.0223
Brugia malayi Hemopexin family protein 0.0653 0.1803 0.2483
Trichomonas vaginalis exonuclease%2C+putative 0.0014 0.0009 0.0083
Echinococcus multilocularis neuropeptide s receptor 0.0425 0.1162 0.2308
Schistosoma mansoni hypothetical protein 0.0027 0.0045 0.0223
Echinococcus granulosus lamin 0.0025 0.004 0.008
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0091 0.0305
Schistosoma mansoni lamin 0.0025 0.004 0.0198
Onchocerca volvulus Serine\/threonine kinase homolog 0.0087 0.0214 0.0214
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0034 0.0065 0.0129
Loa Loa (eye worm) TAR-binding protein 0.0049 0.0107 0.0324
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0032 0.0094
Loa Loa (eye worm) hypothetical protein 0.0025 0.0041 0.0125
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0008 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0214 0.3302
Loa Loa (eye worm) glutaminase 2 0.0239 0.0641 0.1938
Echinococcus granulosus exonuclease 1 0.0014 0.0009 0.0017
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0036 0.0102
Giardia lamblia Flap structure-specific endonuclease 0.0067 0.0158 0.0552
Echinococcus multilocularis smad 0.0021 0.0029 0.0058
Giardia lamblia DINP protein human, muc B family 0.008 0.0196 0.0694
Mycobacterium ulcerans glutaminase 0.0239 0.0641 0.3616
Brugia malayi hypothetical protein 0.0013 0.0006 0.0008
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0014 0.0009 0.0003
Leishmania major mitochondrial DNA polymerase beta 0.0264 0.0712 0.2602
Schistosoma mansoni intermediate filament proteins 0.0025 0.004 0.0198
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0032 0.0085
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.002 0.0027 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0239 0.0854
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0214 0.3302
Brugia malayi mbt repeat family protein 0.0044 0.0093 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0036 0.0102
Brugia malayi isocitrate dehydrogenase 0.0014 0.0009 0.0013
Echinococcus multilocularis polycomb protein SCMH1 0.0044 0.0093 0.0186
Echinococcus multilocularis BRK domain containing protein 0.0021 0.0029 0.0058
Brugia malayi Importin beta-1 subunit 0.0025 0.0041 0.0057
Schistosoma mansoni cpg binding protein 0.0084 0.0205 0.1013
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0036 0.0179
Echinococcus multilocularis mothers against decapentaplegic 5 0.0021 0.0029 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0214 0.3302
Brugia malayi Bloom's syndrome protein homolog 0.0073 0.0174 0.024
Echinococcus multilocularis peregrin 0.001 0.0000030378 0.0000033955
Entamoeba histolytica hypothetical protein 0.0253 0.0681 0.2735
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0356 0.0968 0.1922
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0032 0.0089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0014 0.0025
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0018 0.0053
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0041 0.0121
Loa Loa (eye worm) hypothetical protein 0.0042 0.0088 0.0267
Plasmodium vivax flap endonuclease 1, putative 0.0067 0.0158 0.0582
Schistosoma mansoni smad1 5 8 and 0.0021 0.0029 0.0143
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.008 0.0196 0.1077
Mycobacterium ulcerans hydrolase 0.0633 0.1745 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0088 0.0436
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0017 0.0019 0.0039
Schistosoma mansoni myelin transcription factor 1 myt1 0.005 0.011 0.0545
Trypanosoma brucei unspecified product 0.0052 0.0116 0.0399
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0034 0.0065 0.023
Loa Loa (eye worm) hypothetical protein 0.0131 0.0337 0.102
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0264 0.0712 0.2602
Echinococcus multilocularis disintegrin and metalloproteinase 0.0056 0.0129 0.0256
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0036 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0094 0.0314
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0239 0.0854
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0009 0.0019
Brugia malayi hypothetical protein 0.0059 0.0136 0.0188
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0028 0.005 0.0155
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0067 0.0158 0.0552
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0098 0.0329
Brugia malayi Muscleblind-like protein 0.0268 0.0722 0.0994
Brugia malayi Matrixin family protein 0.052 0.1427 0.1966
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0014 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0407 0.1112 0.3359
Plasmodium falciparum flap endonuclease 1 0.0067 0.0158 0.0582
Brugia malayi N-terminal motif family protein 0.0166 0.0436 0.06
Echinococcus granulosus Chromo domain 0.0021 0.0029 0.0058
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0009
Schistosoma mansoni ap endonuclease 0.0034 0.0065 0.0321
Echinococcus multilocularis disco interacting protein 2 0.0035 0.0068 0.0134
Echinococcus granulosus Smad4 0.0021 0.0029 0.0058
Schistosoma mansoni cpg binding protein 0.0084 0.0205 0.1013
Plasmodium vivax DEAD/DEAH helicase, putative 0.0019 0.0023 0.0086
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0009 0.0003
Brugia malayi hypothetical protein 0.0407 0.1112 0.1531
Loa Loa (eye worm) hypothetical protein 0.0268 0.0722 0.2181
Echinococcus multilocularis BRK domain containing protein 0.0021 0.0029 0.0058
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0067 0.0158 0.0552
Echinococcus multilocularis musashi 0.0025 0.004 0.008
Loa Loa (eye worm) matrix metalloproteinase 0.052 0.1427 0.4313
Echinococcus multilocularis adam 0.0099 0.0247 0.049
Trypanosoma brucei PAB1-binding protein , putative 0.0019 0.0025 0.006
Loa Loa (eye worm) BRM protein 0.0077 0.0186 0.0563
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0017 0.0019 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0094 0.0314
Loa Loa (eye worm) hypothetical protein 0.0056 0.0129 0.039
Loa Loa (eye worm) hypothetical protein 0.005 0.011 0.0334
Schistosoma mansoni helicase 0.001 0.0000013286 0.0000065516
Echinococcus multilocularis dnaJ subfamily B 0.0734 0.2028 0.4028
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0017 0.0019 0.0038
Loa Loa (eye worm) MH2 domain-containing protein 0.0306 0.0828 0.2503
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0087 0.0214 0.0425
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0017 0.0019 0.007
Schistosoma mansoni cpg binding protein 0.0081 0.0197 0.0973
Brugia malayi MH1 domain containing protein 0.0012 0.0003 0.0004
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0017 0.0019 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0088 0.0267
Echinococcus multilocularis dna polymerase eta 0.0095 0.0237 0.0471
Mycobacterium ulcerans hypothetical protein 0.0139 0.0361 0.1994
Loa Loa (eye worm) hypothetical protein 0.0044 0.0093 0.0282
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0009 0.0019
Loa Loa (eye worm) transcription factor SMAD2 0.0306 0.0828 0.2503
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0977 0.271 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0016 0.0016 0.004
Trichomonas vaginalis importin beta-1, putative 0.002 0.0028 0.0386
Echinococcus granulosus GPCR family 2 0.0027 0.0045 0.009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0049
Trypanosoma brucei unspecified product 0.0052 0.0116 0.0399
Echinococcus granulosus dna polymerase eta 0.0095 0.0237 0.0471
Brugia malayi ADAM-TS Spacer 1 family protein 0.0042 0.0088 0.0122
Giardia lamblia Telomerase catalytic subunit 0.0977 0.271 1
Entamoeba histolytica Flap nuclease, putative 0.0067 0.0158 0.0606
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0131 0.0452
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0036 0.0102
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0075 0.0182 0.0362
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0254 0.0681 0.336
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0268 0.0721 0.1432
Echinococcus granulosus cpg binding protein 0.0084 0.0205 0.0408
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0014 0.0025
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0014 0.0009 0.0017
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0009 0.0003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0009 0.0018
Loa Loa (eye worm) BRM protein 0.0062 0.0145 0.0439
Echinococcus multilocularis geminin 0.0148 0.0386 0.0767
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0034 0.0065 0.0209
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0085 0.0117
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0014 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0407 0.1112 0.3359
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0029 0.0074
Schistosoma mansoni helicase 0.012 0.0308 0.1521
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0096
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0022 0.0032 0.0089
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0017 0.0019 0.0039
Echinococcus granulosus neuropeptide receptor A26 0.0425 0.1162 0.2308
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.018 0.0474 0.0942
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0977 0.271 1
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0253 0.0681 0.2735
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0066 0.0156 0.0575
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0268 0.0721 0.1432
Schistosoma mansoni hypothetical protein 0.0057 0.0132 0.065
Loa Loa (eye worm) hypothetical protein 0.0041 0.0085 0.0256
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0091 0.0305
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0056 0.0129 0.0636
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0029 0.0074
Echinococcus granulosus lamin dm0 0.0025 0.004 0.008
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.0239 0.129
Leishmania major hypothetical protein, conserved 0.0019 0.0025 0.006
Schistosoma mansoni helicase 0.001 0.0000013286 0.0000065516
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0268 0.0721 0.0993
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0025 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0214 0.3302
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0025 0.006
Toxoplasma gondii RNA-directed DNA polymerase 0.0977 0.271 1
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0026 0.0044 0.0088
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0239 0.0854
Echinococcus granulosus snurportin 1 0.0269 0.0726 0.1442
Echinococcus granulosus flap endonuclease 1 0.0067 0.0158 0.0313
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0567 0.156 0.7691
Loa Loa (eye worm) mbt repeat family protein 0.0044 0.0093 0.0282
Onchocerca volvulus Matrilysin homolog 0.1152 0.3202 0.3202
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0032 0.0089
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0017 0.0019 0.007
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0036 0.0102
Schistosoma mansoni glutaminase 0.0239 0.0641 0.3162
Echinococcus multilocularis cpg binding protein 0.0084 0.0205 0.0408
Brugia malayi RNA recognition motif domain containing protein 0.0049 0.0107 0.0147
Schistosoma mansoni hypothetical protein 0.0148 0.0386 0.1905
Brugia malayi MH2 domain containing protein 0.0306 0.0828 0.1141
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0032 0.0085
Echinococcus granulosus neuropeptide s receptor 0.0425 0.1162 0.2308
Brugia malayi Flap endonuclease-1 0.0067 0.0158 0.0217
Leishmania major importin beta-1 subunit, putative 0.002 0.0028 0.0072
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0125 0.0321 0.1157
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0032 0.0089
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0034 0.0065 0.0129
Brugia malayi latrophilin 2 splice variant baaae 0.0057 0.0132 0.0182
Schistosoma mansoni kinase 0.0044 0.0094 0.0465
Trypanosoma brucei unspecified product 0.0091 0.0225 0.0801
Toxoplasma gondii hypothetical protein 0.0074 0.0178 0.0628
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0014 0.0009 0.0046
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0032 0.0044
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.1806 0.5034 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0036 0.0116
Loa Loa (eye worm) hypothetical protein 0.052 0.1427 0.4313
Echinococcus granulosus microtubule associated protein 2 0.0634 0.1748 0.3473
Echinococcus granulosus geminin 0.0148 0.0386 0.0767
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0009 0.0019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0088 0.0176
Plasmodium vivax importin-beta 2, putative 0.0025 0.0041 0.0153
Brugia malayi BRM protein 0.012 0.0308 0.0425
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0047 0.0103 0.035
Loa Loa (eye worm) hypothetical protein 0.0166 0.0436 0.1316
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0041 0.0085 0.0168
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0049
Loa Loa (eye worm) MH1 domain-containing protein 0.0021 0.0029 0.0088
Loa Loa (eye worm) hypothetical protein 0.052 0.1427 0.4313
Brugia malayi hypothetical protein 0.0019 0.0025 0.0034
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0075 0.0182 0.0362
Echinococcus multilocularis Smad4 0.0021 0.0029 0.0058
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0087 0.0214 0.076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0239 0.0854
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0087
Brugia malayi hypothetical protein 0.0099 0.0247 0.034
Toxoplasma gondii hypothetical protein 0.0043 0.009 0.0302
Entamoeba histolytica recQ family helicase, putative 0.002 0.0027 0.0073
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0022 0.0032 0.0087
Schistosoma mansoni SET domain protein 0.0012 0.0005 0.0024
Trichomonas vaginalis flap endonuclease-1, putative 0.0014 0.0009 0.0083
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0034 0.0065 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0214 0.3302
Trichomonas vaginalis flap endonuclease-1, putative 0.0014 0.0009 0.0083
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0045 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.0088 0.0267
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0009
Echinococcus granulosus smad 0.0021 0.0029 0.0058
Brugia malayi MH1 domain containing protein 0.0021 0.0029 0.004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0037 0.0075 0.0245
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0014 0.0009 0.0019
Schistosoma mansoni blooms syndrome DNA helicase 0.0052 0.0116 0.0573
Loa Loa (eye worm) isocitrate dehydrogenase 0.0014 0.0009 0.0028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0034 0.0065 0.0209
Schistosoma mansoni sex comb on midleg homolog 0.0044 0.0093 0.0461
Echinococcus multilocularis exonuclease 1 0.0014 0.0009 0.0017
Echinococcus multilocularis lamin dm0 0.0025 0.004 0.008
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0029 0.0142
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0009 0.0003
Echinococcus multilocularis GPCR, family 2 0.0027 0.0045 0.009
Schistosoma mansoni hypothetical protein 0.0148 0.0386 0.1905
Echinococcus multilocularis BRK domain 0.0021 0.0029 0.0058
Mycobacterium ulcerans hypothetical protein 0.0022 0.0032 0.0089
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0021 0.0029 0.0058
Trichomonas vaginalis lymphoid specific helicase, putative 0.0022 0.0032 0.0451
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0088 0.0436
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0034 0.0065 0.0209
Echinococcus multilocularis helicase 0.001 0.0000013286 0.00000000013427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0088 0.0176
Giardia lamblia DNA repair protein RAD52 0.0891 0.2468 0.9105
Plasmodium falciparum DNA repair protein RAD2, putative 0.0014 0.0009 0.0032
Echinococcus multilocularis isocitrate dehydrogenase 0.0014 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0009
Entamoeba histolytica serine/threonine protein kinase, putative 0.0087 0.0214 0.0835
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0074 0.0178 0.0658
Trichomonas vaginalis flap endonuclease-1, putative 0.0014 0.0009 0.0083
Echinococcus multilocularis bloom syndrome protein 0.0073 0.0174 0.0346
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0041 0.0085 0.0312
Brugia malayi Isocitrate dehydrogenase 0.0014 0.0009 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0107 0.0528
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0049
Echinococcus granulosus BRK domain containing protein 0.0021 0.0029 0.0058
Brugia malayi CXXC zinc finger family protein 0.0081 0.0197 0.0272
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0056 0.0129 0.0636
Plasmodium vivax DNA repair protein RAD2, putative 0.0014 0.0009 0.0032
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0034 0.0065 0.5
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0019 0.0023 0.0054
Plasmodium vivax ataxin-2 like protein, putative 0.0019 0.0025 0.0092
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0012 0.0004 0.0008
Echinococcus granulosus adam 17 protease 0.0623 0.1718 0.3413
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0032 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0049
Echinococcus granulosus peregrin 0.001 0.0000030378 0.0000033955
Toxoplasma gondii exonuclease III APE 0.0034 0.0065 0.0209
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0036 0.0102
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0022 0.0032 0.0129
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0087 0.0214 0.0646
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0037 0.0075 0.0245
Onchocerca volvulus 0.0034 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0026
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0099 0.0247 0.1217
Plasmodium vivax exonuclease I, putative 0.0014 0.0009 0.0032
Echinococcus granulosus histone acetyltransferase MYST2 0.005 0.011 0.0219
Onchocerca volvulus 0.052 0.1427 0.1427
Brugia malayi mbt repeat family protein 0.0044 0.0093 0.0129
Schistosoma mansoni sex comb on midleg homolog 0.0044 0.0093 0.0461
Plasmodium falciparum importin beta, putative 0.0025 0.0041 0.0153
Echinococcus multilocularis Chromo domain 0.0021 0.0029 0.0058
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0049 0.0107 0.0324
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0107 0.0528
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.0088 0.0267
Leishmania major DNA polymerase kappa, putative 0.0023 0.0036 0.0102
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0067 0.0158 0.0552
Schistosoma mansoni Smad4 0.0021 0.0029 0.0143
Schistosoma mansoni hypothetical protein 0.0027 0.0045 0.0223
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.005 0.011 0.0219
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0084 0.0206 0.0624
Brugia malayi serine/threonine-protein kinase plk-2 0.0087 0.0214 0.0295
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0041 0.0085 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0214 0.3302
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0016 0.0016 0.5
Brugia malayi Smad1 0.0021 0.0029 0.004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0045 0.009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0117
Echinococcus granulosus DNA methyltransferase 2, putative 0.0017 0.0019 0.0038
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0182 0.0251
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0032 0.0089
Trichomonas vaginalis DNA helicase recq, putative 0.0073 0.0174 0.268
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0107 0.0528
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0029 0.0074
Brugia malayi MH2 domain containing protein 0.0021 0.0029 0.004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.0088 0.0122
Loa Loa (eye worm) hypothetical protein 0.0095 0.0237 0.0716
Echinococcus multilocularis dna polymerase kappa 0.0096 0.0239 0.0475
Loa Loa (eye worm) hypothetical protein 0.0057 0.0132 0.0398
Schistosoma mansoni smad 0.0021 0.0029 0.0143
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0032 0.0085
Loa Loa (eye worm) glutaminase 0.0239 0.0641 0.1938
Trypanosoma brucei telomerase reverse transcriptase 0.0977 0.271 1
Schistosoma mansoni lozenge 0.0051 0.0114 0.0561
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0239 0.0854
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0047 0.0103 0.035
Loa Loa (eye worm) hypothetical protein 0.052 0.1427 0.4313
Loa Loa (eye worm) XPG I-region family protein 0.0014 0.0009 0.0026
Echinococcus granulosus adam 0.0099 0.0247 0.049
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0034 0.0065 0.0241
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0041 0.0085 0.0168
Schistosoma mansoni hypothetical protein 0.0653 0.1803 0.889
Entamoeba histolytica hypothetical protein 0.0059 0.0136 0.0519
Loa Loa (eye worm) intermediate filament protein 0.0025 0.004 0.0121
Trypanosoma cruzi DNA polymerase eta, putative 0.0095 0.0237 0.0845
Schistosoma mansoni SET domain protein 0.0026 0.0044 0.0219
Plasmodium falciparum acyl-CoA synthetase 0.0016 0.0016 0.006
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0036 0.0102
Plasmodium falciparum exonuclease I, putative 0.0014 0.0009 0.0032
Brugia malayi XPG I-region family protein 0.0014 0.0009 0.0012
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0034 0.0065 0.0241
Brugia malayi Disco-interacting protein 2 homolog 0.0034 0.0065 0.009
Schistosoma mansoni hypothetical protein 0.0027 0.0045 0.0223
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0014 0.0009 0.0017
Echinococcus multilocularis muscleblind protein 1 0.0268 0.0722 0.1434
Schistosoma mansoni dihydroceramide desaturase 0.0056 0.0129 0.0636
Schistosoma mansoni exonuclease 0.0014 0.0009 0.0043
Loa Loa (eye worm) CXXC zinc finger family protein 0.0081 0.0197 0.0596
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0036 0.0102
Entamoeba histolytica hypothetical protein 0.0059 0.0136 0.0519
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0012 0.0004 0.0008
Brugia malayi Telomerase reverse transcriptase 0.26 0.7261 1
Toxoplasma gondii LsmAD domain-containing protein 0.0019 0.0025 0.006
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.1806 0.5034 1
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0035 0.0068 0.0333
Brugia malayi cytoplasmic intermediate filament protein 0.0013 0.0008 0.0011
Echinococcus granulosus SAM and MBT domain containing protein 0.0044 0.0093 0.0186
Treponema pallidum exodeoxyribonuclease (exoA) 0.0034 0.0065 1
Schistosoma mansoni DNA polymerase eta 0.0095 0.0237 0.1168
Brugia malayi RNA binding protein 0.0049 0.0107 0.0147
Echinococcus granulosus TGF beta signal transducer SmadC 0.0021 0.0029 0.0058
Echinococcus granulosus importin subunit beta 1 0.0025 0.0041 0.0082
Loa Loa (eye worm) runx1 0.0051 0.0114 0.0344
Giardia lamblia Kinase, PLK 0.0087 0.0214 0.076
Brugia malayi MH1 domain containing protein 0.0012 0.0003 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0239 0.0854
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0019 0.0023 0.0086
Trypanosoma brucei DNA polymerase IV, putative 0.0091 0.0225 0.0801
Trichomonas vaginalis flap endonuclease-1, putative 0.0014 0.0009 0.0083
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0891 0.2468 1
Entamoeba histolytica hypothetical protein 0.0059 0.0136 0.0519
Schistosoma mansoni microtubule-associated protein tau 0.0634 0.1748 0.8622
Loa Loa (eye worm) helicase DNA-binding protein 0.0021 0.0029 0.0088
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0034 0.0065 0.0283
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0009 0.0003
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0034 0.0065 0.0209
Brugia malayi TAR-binding protein 0.0049 0.0107 0.0147
Entamoeba histolytica hypothetical protein 0.0059 0.0136 0.0519
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0009 0.0044
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0045 0.0098 0.033
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0034 0.0065 0.0197
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0091 0.1375
Echinococcus granulosus muscleblind protein 0.0268 0.0722 0.1434
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0075
Brugia malayi MH2 domain containing protein 0.0021 0.0029 0.004
Echinococcus granulosus intermediate filament protein 0.0025 0.004 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0239 0.0854
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0009 0.0003
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0269 0.0726 0.2193
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0125 0.0321 0.1157
Echinococcus multilocularis muscleblind protein 0.0268 0.0722 0.1434
Mycobacterium tuberculosis Conserved hypothetical protein 0.0139 0.0361 0.2026
Onchocerca volvulus Matrilysin homolog 0.052 0.1427 0.1427
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0075 0.0182 0.0898
Brugia malayi Matrixin family protein 0.052 0.1427 0.1966
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0107 0.0528
Schistosoma mansoni transcription factor LCR-F1 0.0059 0.0136 0.0673
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0059 0.0136 0.0271
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0047 0.0103 0.035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0026
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0166 0.0436 0.0436
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0214 0.3302
Echinococcus multilocularis BRK domain containing protein 0.0021 0.0029 0.0058
Leishmania major telomerase reverse transcriptase, putative 0.0977 0.271 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0633 0.1745 1
Echinococcus granulosus global transcription activator snf2l2 0.012 0.0308 0.0613
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0032 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0025 0.006
Loa Loa (eye worm) nuclear factor I 0.0012 0.0003 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0107 0.0528
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0045 0.009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0059 0.0136 0.0271
Leishmania major DNA damage repair protein, putative 0.0023 0.0036 0.0102
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0239 0.0854
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0239 0.0854
Leishmania major DNA polymerase eta, putative 0.0043 0.0091 0.0305
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0239 0.0854
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0037 0.0075 0.0245
Trypanosoma brucei DNA polymerase eta, putative 0.0095 0.0237 0.0845
Echinococcus multilocularis snurportin 1 0.0269 0.0726 0.1442
Brugia malayi intermediate filament protein 0.0025 0.004 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0239 0.0854
Onchocerca volvulus Matrix metalloproteinase homolog 0.1152 0.3202 0.3202
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0131 0.0452
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0014 0.0009 0.0043
Loa Loa (eye worm) matrixin family protein 0.1152 0.3202 0.9674
Schistosoma mansoni hypothetical protein 0.0024 0.0037 0.0184
Plasmodium vivax acyl-CoA synthetase, putative 0.0016 0.0016 0.006
Plasmodium vivax helicase, putative 0.001 0.0000013286 0.0000049026
Trypanosoma brucei polo-like protein kinase 0.0087 0.0214 0.076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0088 0.0176
Giardia lamblia Sgs1 DNA helicase, putative 0.0041 0.0085 0.0282
Trichomonas vaginalis ap endonuclease, putative 0.0034 0.0065 0.097
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0056 0.0129 0.0256
Leishmania major DNA polymerase kappa, putative 0.008 0.0196 0.0694
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0131 0.0452
Entamoeba histolytica deoxycytidyl transferase, putative 0.0075 0.0182 0.0705
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0037 0.0075 0.0245
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0084 0.0206 0.0284
Echinococcus granulosus tar DNA binding protein 0.0049 0.0107 0.0213
Loa Loa (eye worm) latrophilin receptor protein 2 0.0027 0.0045 0.0137
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0056 0.0129 0.0256
Trypanosoma cruzi importin beta-1 subunit, putative 0.002 0.0028 0.0072
Schistosoma mansoni hypothetical protein 0.0269 0.0726 0.3579
Echinococcus multilocularis lamin 0.0025 0.004 0.008
Echinococcus multilocularis Protein lozenge 0.0051 0.0114 0.0226
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0045 0.009
Loa Loa (eye worm) MH2 domain-containing protein 0.0021 0.0029 0.0088
Echinococcus multilocularis neuropeptide receptor A26 0.0425 0.1162 0.2308
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0214 0.1055
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0633 0.1745 0.2403
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0036 0.0102
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0014 0.0009 0.0019
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0041 0.0085 0.0168
Echinococcus granulosus flap endonuclease GEN 1 0.0014 0.0009 0.0017
Onchocerca volvulus 0.0022 0.0032 0.0032
Echinococcus granulosus helicase 0.001 0.0000013286 0.00000000013427
Loa Loa (eye worm) matrixin family protein 0.1173 0.326 0.9849
Loa Loa (eye worm) hypothetical protein 0.0034 0.0065 0.0197
Onchocerca volvulus 0.0044 0.0093 0.0093
Echinococcus multilocularis importin subunit beta 1 0.0025 0.0041 0.0082
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0264 0.0712 0.2602
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0041 0.0085 0.0256
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0196 0.0694
Echinococcus multilocularis tar DNA binding protein 0.0049 0.0107 0.0213
Loa Loa (eye worm) hypothetical protein 0.0084 0.0206 0.0624
Echinococcus granulosus dnaJ subfamily B 0.0734 0.2028 0.4028
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0014 0.0009 0.0034
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0021 0.0029 0.0143
Brugia malayi polk-prov protein 0.0044 0.0094 0.0129
Echinococcus granulosus disintegrin and metalloproteinase 0.0056 0.0129 0.0256
Onchocerca volvulus 0.0081 0.0197 0.0197
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0045 0.0062
Toxoplasma gondii histone lysine methyltransferase SET1 0.0102 0.0256 0.0914
Schistosoma mansoni mixed-lineage leukemia protein mll 0.011 0.0279 0.1378
Echinococcus granulosus polycomb protein SCMH1 0.0044 0.0093 0.0186
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0137
Loa Loa (eye worm) flap endonuclease-1 0.0067 0.0158 0.0476
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0032 0.0044
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0025 0.0092
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0044 0.0093 0.0461
Echinococcus multilocularis BRK domain containing protein 0.0021 0.0029 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0239 0.0854
Echinococcus multilocularis SAM and MBT domain containing protein 0.0044 0.0093 0.0186
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.005 0.011 0.0152
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0009 0.0018
Trypanosoma cruzi polo-like protein kinase, putative 0.0087 0.0214 0.076
Echinococcus multilocularis BRK domain containing protein 0.0021 0.0029 0.0058
Echinococcus multilocularis adam 17 protease 0.0567 0.156 0.3098
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0018 0.0035
Entamoeba histolytica recQ family helicase, putative 0.0047 0.0103 0.0385
Loa Loa (eye worm) reprolysin 0.0056 0.0129 0.039
Trichomonas vaginalis ap endonuclease, putative 0.0034 0.0065 0.097
Echinococcus multilocularis flap endonuclease GEN 1 0.0014 0.0009 0.0017
Brugia malayi MH1 domain containing protein 0.0021 0.0029 0.004

Activities

Activity type Activity value Assay description Source Reference
I50 (functional) = 4.2 uM Concentration required to effect a 50% reduction in microtubule polymerization ChEMBL. 8459402
IC50 (functional) = 4.2 uM Concentration required to effect a 50% reduction in microtubule polymerization ChEMBL. 8459402
Inhibition (functional) = 21.9 % Percent inhibition of [3H]-colchicine binding to tubulin with molar ratio of 1:1 (inhibitor: [3H]-colchicine) ChEMBL. 8459402
Inhibition (functional) = 21.9 % Percent inhibition of [3H]-colchicine binding to tubulin with molar ratio of 1:1 (inhibitor: [3H]-colchicine) ChEMBL. 8459402
Inhibition (functional) = 69.4 % Percent inhibition of [3H]-colchicine binding to tubulin with molar ratio of 1:10 (inhibitor: [3H]-colchicine) ChEMBL. 8459402
Inhibition (functional) = 69.4 % Percent inhibition of [3H]-colchicine binding to tubulin with molar ratio of 1:10 (inhibitor: [3H]-colchicine) ChEMBL. 8459402

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 8459402

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.