Detailed information for compound 302132

Basic information

Technical information
  • TDR Targets ID: 302132
  • Name: methyl 4-[(8-bromo-3,7-dimethyl-2,6-dioxopuri n-1-yl)methyl]benzoate
  • MW: 407.219 | Formula: C16H15BrN4O4
  • H donors: 0 H acceptors: 4 LogP: 1.94 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(cc1)Cn1c(=O)c2n(C)c(nc2n(c1=O)C)Br
  • InChi: 1S/C16H15BrN4O4/c1-19-11-12(18-15(19)17)20(2)16(24)21(13(11)22)8-9-4-6-10(7-5-9)14(23)25-3/h4-7H,8H2,1-3H3
  • InChiKey: WARHQDDDNLSREK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 4-[(8-bromo-3,7-dimethyl-2,6-dioxo-purin-1-yl)methyl]benzoate
  • 4-[(8-bromo-3,7-dimethyl-2,6-dioxo-1-purinyl)methyl]benzoic acid methyl ester
  • 4-[(8-bromo-2,6-diketo-3,7-dimethyl-purin-1-yl)methyl]benzoic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0067 0.137 0.2068
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0272 0.0272
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0005 0.0005
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.213 0.213
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0272 0.0467
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0272 0.0405
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0237 0.0352
Echinococcus multilocularis Chromo domain 0.0012 0.0052 0.0052
Leishmania major DNA damage repair protein, putative 0.0012 0.0066 0.0084
Loa Loa (eye worm) hypothetical protein 0.0051 0.0983 0.1482
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0818 0.1169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0127 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0272 0.0405
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0272 0.0405
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0235 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0272 0.0405
Plasmodium vivax SET domain protein, putative 0.0033 0.0557 0.127
Entamoeba histolytica phosphoglycerate kinase, putative 0.0177 0.4025 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0602 0.084
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0272 0.0272
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0272 0.0272
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0983 0.0983
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0052 0.0052
Brugia malayi nuclear receptor NHR-88 0.0021 0.0272 0.0405
Schistosoma mansoni phosphoglycerate kinase 0.0177 0.4025 0.4025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0911 0.0911
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.1301 0.1301
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0005 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0433 0.0585
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0013 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0067 0.137 0.2068
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0209 0.0309
Echinococcus multilocularis cpg binding protein 0.0034 0.0574 0.0574
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0272 0.0405
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0272 0.0272
Entamoeba histolytica hypothetical protein 0.0012 0.0052 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0272 0.0405
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.213 0.3171
Schistosoma mansoni zinc finger protein 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Trypanosoma brucei phosphoglycerate kinase 0.0065 0.133 0.1811
Loa Loa (eye worm) hypothetical protein 0.0072 0.1506 0.2275
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0272 0.0272
Echinococcus granulosus dna polymerase kappa 0.004 0.0732 0.0732
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.213 0.3219
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0732 0.0994
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0272 0.0272
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0058 0.0072
Brugia malayi hypothetical protein 0.0011 0.0034 0.0044
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0177 0.4025 0.609
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.1301 0.1301
Schistosoma mansoni jun-related protein 0.0133 0.2959 0.2959
Giardia lamblia DINP protein human, muc B family 0.004 0.0732 0.1682
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0052 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0066 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0272 0.0405
Schistosoma mansoni chromobox protein 0.0072 0.151 0.151
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0272 0.0405
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Trichomonas vaginalis rotamase, putative 0.0034 0.0583 0.081
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.213 0.3171
Brugia malayi polk-prov protein 0.0012 0.0066 0.0093
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0072
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0193 0.0193
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0418 0.1028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0272 0.0405
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0936 0.135
Onchocerca volvulus 0.0021 0.0272 0.0467
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0193 0.0193
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.3343 0.4561
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0372 0.0372
Schistosoma mansoni hepatoma derived growth factor 0.001 0.0005 0.0005
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0373 0.0503
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0732 0.1038
Entamoeba histolytica hypothetical protein 0.0012 0.0058 0.0132
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0272 0.0272
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.0323 0.0435
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0583 0.079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0215 0.0248
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0052 0.0072
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0666 0.0666
Entamoeba histolytica hypothetical protein 0.0012 0.0052 0.0117
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0141 0.0141
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0272 0.0272
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0235 0.0235
Plasmodium falciparum DNA repair protein REV1, putative 0.0012 0.0066 0.0036
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0005 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0732 0.0994
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0058 0.0072
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0058 0.0072
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0272 0.0405
Schistosoma mansoni nuclear receptor 0.001 0.0005 0.0005
Brugia malayi hypothetical protein 0.0011 0.0034 0.0044
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0072 0.1506 0.1506
Echinococcus granulosus chromobox protein 1 0.0072 0.151 0.151
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0177 0.4025 0.5493
Loa Loa (eye worm) hypothetical protein 0.0021 0.0272 0.0405
Trichomonas vaginalis DNA helicase recq1, putative 0.0047 0.0901 0.1296
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0418 0.1028
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0418 0.0889
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0433 0.0585
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0005 0.0005
Echinococcus multilocularis dna polymerase kappa 0.004 0.0732 0.0732
Onchocerca volvulus 0.0045 0.0842 0.1461
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.133 0.1811
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0034 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0842 0.0842
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0936 0.135
Brugia malayi Bloom's syndrome protein homolog 0.0047 0.0901 0.1358
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0732 0.0994
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0141 0.0141
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.213 0.3171
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.213 0.2904
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0235 0.0573
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0066 0.0084
Brugia malayi hypothetical protein 0.0012 0.0052 0.0072
Plasmodium falciparum phosphoglycerate kinase 0.0177 0.4025 1
Leishmania major phosphoglycerate kinase C, glycosomal 0.0177 0.4025 0.5493
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0005 0.0001
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0704 0.0955
Trichomonas vaginalis chromobox protein, putative 0.0072 0.151 0.2224
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0602 0.0905
Brugia malayi nuclear receptor RXR 0.001 0.0005 0.0001
Schistosoma mansoni ap endonuclease 0.002 0.0237 0.0237
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0005 0.0001
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0066 0.0066
Schistosoma mansoni rotamase 0.0035 0.0602 0.0602
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0235 0.0461
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.3343 0.4561
Brugia malayi steroid hormone receptor 0.0021 0.0272 0.0405
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0143 0.3216 0.4864
Schistosoma mansoni cpg binding protein 0.003 0.0485 0.0485
Giardia lamblia Phosphoglycerate kinase 0.0177 0.4025 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0272 0.0405
Entamoeba histolytica recQ family DNA helicase 0.001 0.0005 0.0002
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0066 0.0084
Echinococcus granulosus phosphoglycerate kinase 1 0.0177 0.4025 0.4025
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0021 0.0022
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0058 0.0072
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0141 0.0206
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0005 0.0001
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0418 0.0565
Loa Loa (eye worm) hypothetical protein 0.0021 0.0272 0.0405
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0005 0.0005
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0005 0.0001
Schistosoma mansoni zinc finger protein 0.0016 0.0149 0.0149
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0058 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0458 0.062
Onchocerca volvulus 0.0032 0.0533 0.0921
Brugia malayi nuclear hormone receptor 0.0021 0.0272 0.0405
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0272 0.0272
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0044 0.0044
Echinococcus granulosus cpg binding protein 0.0034 0.0574 0.0574
Schistosoma mansoni nuclear receptor 0.001 0.0005 0.0005
Schistosoma mansoni cpg binding protein 0.0034 0.0574 0.0574
Echinococcus granulosus jun protein 0.0163 0.3695 0.3695
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.213 0.213
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0058 0.0072
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0005 0.0005
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0732 0.0732
Brugia malayi ecdysteroid receptor 0.0021 0.0272 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0458 0.062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0557 0.0557
Echinococcus granulosus bloom syndrome protein 0.0047 0.0901 0.0901
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0237 0.0541
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0272 0.0272
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0005 0.0002
Trypanosoma brucei phosphoglycerate kinase 0.0177 0.4025 0.5493
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0235 0.0235
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0052 0.0117
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0237 0.0237
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.133 0.1811
Brugia malayi conserved hypotetical protein 0.001 0.0005 0.0001
Brugia malayi hypothetical protein 0.0128 0.2851 0.4313
Trypanosoma brucei ISWI complex protein 0.0016 0.0149 0.0198
Loa Loa (eye worm) hypothetical protein 0.0021 0.0272 0.0405
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0667 0.0667
Schistosoma mansoni nuclear hormone receptor 0.001 0.0005 0.0005
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0237 0.0318
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0732 0.0732
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0052 0.0117
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0037 0.0667 0.1647
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0983 0.0983
Brugia malayi Phosphoglycerate kinase 0.0177 0.4025 0.609
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0732 0.0994
Brugia malayi Pre-SET motif family protein 0.0033 0.0557 0.0836
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Leishmania major DNA polymerase eta, putative 0.0039 0.0704 0.0955
Brugia malayi Bromodomain containing protein 0.004 0.0725 0.1091
Echinococcus multilocularis dna polymerase eta 0.0067 0.137 0.137
Schistosoma mansoni SET domain protein 0.0016 0.0164 0.0164
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0272 0.0272
Brugia malayi ecdysone receptor 0.001 0.0005 0.0001
Entamoeba histolytica hypothetical protein 0.0037 0.0667 0.1647
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0829 0.1127
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.213 0.3171
Loa Loa (eye worm) hypothetical protein 0.0155 0.3504 0.5301
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0058 0.0009
Trichomonas vaginalis set domain proteins, putative 0.0248 0.5736 0.8673
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0052 0.00000000029463
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0237 0.0466
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0034 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0215 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0744 0.1056
Mycobacterium ulcerans phosphoglycerate kinase 0.0177 0.4025 0.6053
Chlamydia trachomatis phosphoglycerate kinase 0.0177 0.4025 0.5
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0005 0.0005
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0237 0.0318
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0058 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0272 0.0405
Mycobacterium ulcerans glutaminase 0.0284 0.6606 1
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0177 0.4025 0.6062
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0373 0.0489
Loa Loa (eye worm) hypothetical protein 0.0046 0.0875 0.1318
Brugia malayi CXXC zinc finger family protein 0.003 0.0485 0.0728
Schistosoma mansoni tsg101-related 0.0049 0.095 0.095
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0237 0.0466
Entamoeba histolytica hypothetical protein 0.0012 0.0058 0.0132
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.3747 0.9266
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0818 0.1169
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.133 0.1811
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0066 0.0084
Trichomonas vaginalis DNA helicase recq, putative 0.0047 0.0901 0.1296
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0052 0.0072
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0036 0.063 0.063
Echinococcus granulosus PWWP domain containing protein 2A 0.001 0.0005 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0732 0.0994
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0272 0.0272
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0732 0.0994
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0272 0.0405
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0005 0.0001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0272 0.0405
Toxoplasma gondii hypothetical protein 0.0051 0.0985 0.2439
Schistosoma mansoni hypothetical protein 0.0021 0.0283 0.0283
Treponema pallidum phosphoglycerate kinase 0.0177 0.4025 1
Schistosoma mansoni tsg101-related 0.006 0.1215 0.1215
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0089 0.0127
Schistosoma mansoni tsg101-related 0.006 0.1215 0.1215
Echinococcus granulosus chromobox protein 1 0.0072 0.151 0.151
Trypanosoma cruzi DNA polymerase eta, putative 0.0067 0.137 0.1865
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0066 0.0084
Echinococcus multilocularis dnaJ subfamily B 0.0425 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0732 0.1307
Brugia malayi Phosphoglycerate kinase 0.0065 0.133 0.2007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0533 0.08
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0058 0.0072
Leishmania major DNA polymerase kappa, putative 0.004 0.0732 0.0994
Loa Loa (eye worm) DR-78 0.001 0.0005 0.0001
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0005 0.0005
Echinococcus granulosus zinc finger protein 0.0022 0.0297 0.0297
Trypanosoma brucei phosphoglycerate kinase, putative 0.0065 0.133 0.1811
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0272 0.0405
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0237 0.0577
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0058 0.0072
Onchocerca volvulus 0.0012 0.0052 0.0082
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0021 0.0022
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0177 0.4025 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.133 0.1811
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0052 0.0117
Brugia malayi nuclear receptor NHR-88 0.001 0.0005 0.0001
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0058 0.0072
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0005 0.0005
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0052 0.0117
Plasmodium vivax phosphoglycerate kinase, putative 0.0177 0.4025 1
Brugia malayi nuclear receptor NHR-67 0.001 0.0005 0.0001
Mycobacterium ulcerans hypothetical protein 0.0165 0.3747 0.5628
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0744 0.1289
Brugia malayi hypothetical protein 0.001 0.0005 0.0001
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.213 0.3219
Trichomonas vaginalis hypothetical protein 0.0035 0.0614 0.0858
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0272 0.0272
Onchocerca volvulus 0.0248 0.5736 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0044
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0021 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0066 0.0084
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0732 0.1038
Trichomonas vaginalis glutaminase, putative 0.0284 0.6606 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0052 0.00000000029463
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0667 0.0667
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0272 0.0405
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0272 0.0272
Leishmania major hypothetical protein, conserved 0.0023 0.0323 0.0435
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0066 0.0084
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.1242 0.3078
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0005 0.0001
Schistosoma mansoni hypothetical protein 0.0133 0.2959 0.2959
Schistosoma mansoni hypothetical protein 0.0425 1 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0373 0.0503
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0072
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0044 0.0059
Schistosoma mansoni zinc finger protein 0.0022 0.0297 0.0297
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0732 0.0994
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0272 0.0272
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0163 0.3695 0.3695
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0065 0.133 0.1811
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0058 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0272 0.0405
Trypanosoma brucei DNA polymerase eta, putative 0.0067 0.137 0.1865
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0237 0.0578
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0066 0.0084
Giardia lamblia Kinase, PLK 0.0098 0.213 0.5213
Brugia malayi CHD4 protein 0.0016 0.0141 0.0206
Entamoeba histolytica hypothetical protein 0.0012 0.0058 0.0132
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0557 0.0557
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0177 0.4025 0.6062
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0373 0.0503
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0272 0.0272
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0235 0.0235
Leishmania major phosphoglycerate kinase B, cytosolic 0.0177 0.4025 0.5493
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0272 0.0467
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0049 0.095 0.2352
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0044
Entamoeba histolytica hypothetical protein 0.0012 0.0058 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0983 0.0983
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0066 0.0153
Brugia malayi Muscleblind-like protein 0.0155 0.3504 0.5301
Brugia malayi Bromodomain containing protein 0.008 0.1684 0.2544
Leishmania major hypothetical protein, conserved 0.0016 0.0149 0.0198
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.213 0.5287
Trypanosoma brucei unspecified product 0.0028 0.0433 0.0585
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0072
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0666 0.0666
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0005
Brugia malayi bZIP transcription factor family protein 0.0163 0.3695 0.5591
Loa Loa (eye worm) hypothetical protein 0.0021 0.0272 0.0405
Echinococcus granulosus PWWP domain containing protein 2A 0.001 0.0005 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0272 0.0405
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.213 0.3171
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0052 0.00000000048606
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0373 0.0915
Loa Loa (eye worm) hypothetical protein 0.0073 0.1536 0.232
Echinococcus granulosus hepatoma derived growth factor protein 0.001 0.0005 0.0005
Echinococcus multilocularis muscleblind protein 0.0155 0.3504 0.3504
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0911 0.1373
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0005 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0732 0.0994
Entamoeba histolytica hypothetical protein 0.0012 0.0052 0.0117
Schistosoma mansoni phosphoglycerate kinase 0.0177 0.4025 0.4025
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0235 0.0426
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.133 0.1811
Entamoeba histolytica hypothetical protein 0.0037 0.0667 0.1647
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0911 0.0911
Plasmodium falciparum flap endonuclease 1 0.0027 0.0418 0.0922
Schistosoma mansoni bromodomain containing protein 0.0067 0.1391 0.1391
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0272 0.0272
Echinococcus granulosus dna polymerase eta 0.0067 0.137 0.137
Onchocerca volvulus 0.0012 0.0052 0.0082
Echinococcus multilocularis hepatoma derived growth factor protein 0.001 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0215 0.0248
Echinococcus granulosus flap endonuclease 1 0.0027 0.0418 0.0418
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.151 0.228
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0418 0.0565
Onchocerca volvulus 0.001 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0272 0.0272
Loa Loa (eye worm) RecQ helicase 0.0047 0.0901 0.1358
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0032 0.0534 0.1213
Schistosoma mansoni hypothetical protein 0.001 0.0005 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0911 0.0911
Onchocerca volvulus 0.001 0.0005 0.0001
Loa Loa (eye worm) glutaminase 2 0.0284 0.6606 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0058 0.0072
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0829 0.1127
Schistosoma mansoni glutaminase 0.0284 0.6606 0.6606
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0235 0.0349
Brugia malayi PHD-finger family protein 0.0028 0.0431 0.0646
Trypanosoma brucei polo-like protein kinase 0.0098 0.213 0.2904
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0911 0.1373
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0583 0.1438
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0272 0.0272
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0818 0.1419
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0272 0.0272
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0283 0.0421
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0044
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0066 0.0084
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0052 0.00000000048606
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.7323 1
Echinococcus multilocularis PWWP domain containing protein 2A 0.001 0.0005 0.0005
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0272 0.0405
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0052 0.0117
Schistosoma mansoni DNA polymerase eta 0.0067 0.137 0.137
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0732 0.0994
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.213 0.3171
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0732 0.1102
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0525 0.1293
Schistosoma mansoni coup transcription factor 0.0021 0.0272 0.0272
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0034 0.0044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0272 0.0272
Schistosoma mansoni kinase 0.005 0.0968 0.0968
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0034 0.0034
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0732 0.0732
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0272 0.0272
Schistosoma mansoni SET domain protein 0.0036 0.063 0.063
Trypanosoma brucei phosphoglycerate kinase 0.0177 0.4025 0.5493
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0418 0.0626
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0036 0.063 0.063
Leishmania major DNA polymerase kappa, putative 0.0012 0.0066 0.0084
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0732 0.0994
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0052 0.0052
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0583 0.079
Schistosoma mansoni hepatoma derived growth factor 0.001 0.0005 0.0005
Schistosoma mansoni ap endonuclease 0.002 0.0237 0.0237
Schistosoma mansoni blooms syndrome DNA helicase 0.0037 0.0662 0.0662
Echinococcus granulosus Chromo domain 0.0012 0.0052 0.0052
Echinococcus multilocularis chromobox protein 2 0.0012 0.0052 0.0052
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0193 0.0193
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0272 0.0405
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0052 0.0117
Trichomonas vaginalis chromobox protein, putative 0.0072 0.151 0.2224
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0237 0.0261
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0066 0.0036
Loa Loa (eye worm) hypothetical protein 0.0159 0.3587 0.5428
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0272 0.0405
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0237 0.0352
Echinococcus granulosus peregrin 0.0012 0.0064 0.0064
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0583 0.1438
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0272 0.0272
Echinococcus multilocularis chromobox protein 1 0.0072 0.151 0.151
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0235 0.0235
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0732 0.0994
Echinococcus multilocularis expressed protein 0.0035 0.0602 0.0602
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0066 0.0084
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0237 0.0318
Schistosoma mansoni nuclear hormone receptor 0.001 0.0005 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.7323 1
Schistosoma mansoni DNA helicase recq5 0.0019 0.0235 0.0235
Schistosoma mansoni hypothetical protein 0.001 0.0005 0.0005
Loa Loa (eye worm) helicase 0.0012 0.0052 0.0072
Schistosoma mansoni DNA helicase recq1 0.0019 0.0235 0.0235
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0052 0.0072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.1346 0.1346
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0177 0.4025 1
Schistosoma mansoni hypothetical protein 0.0012 0.0052 0.0052
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0237 0.0318
Trypanosoma brucei unspecified product 0.004 0.0732 0.0994
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.213 0.213
Brugia malayi Nuclear hormone receptor E75 0.001 0.0005 0.0001
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0418 0.0559
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.1061 0.1444
Echinococcus multilocularis zinc finger protein 0.0022 0.0297 0.0297
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0066 0.0084
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.3343 0.4561
Toxoplasma gondii exonuclease III APE 0.002 0.0237 0.0578
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0583 0.079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0911 0.0911
Schistosoma mansoni hypothetical protein 0.0037 0.0667 0.0667
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0602 0.0905
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0235 0.0349
Echinococcus granulosus Chromobox protein 3 0.0012 0.0052 0.0052
Echinococcus multilocularis muscleblind protein 1 0.0155 0.3504 0.3504
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.7323 1
Brugia malayi Pre-SET motif family protein 0.0218 0.5017 0.7593
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.5017 0.7593
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0732 0.0994
Schistosoma mansoni hypothetical protein 0.001 0.0005 0.0005
Echinococcus granulosus muscleblind protein 0.0155 0.3504 0.3504
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0005 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0732 0.0994
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0744 0.1056
Brugia malayi nuclear hormone receptor 0.001 0.0005 0.0001
Entamoeba histolytica hypothetical protein 0.0037 0.0667 0.1647
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0486 0.0486
Brugia malayi Heterochromatin protein 1 0.0072 0.151 0.228
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0177 0.4025 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0058 0.0009
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0021 0.0022
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0072 0.1506 0.1506
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0139 0.0133
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0052 0.0052
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0215 0.0248
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0163 0.3695 0.3695
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0911 0.0911
Trypanosoma cruzi ISWI complex protein 0.0016 0.0149 0.0198
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0177 0.4025 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0272 0.0405
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0732 0.1018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0272 0.0405
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0044
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0005 0.0005
Leishmania major DNA polymerase eta, putative 0.0067 0.137 0.1865
Echinococcus multilocularis PWWP domain containing protein 2A 0.001 0.0005 0.0005
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.7323 1
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0418 0.0418
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0732 0.0994
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0732 0.0732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0272 0.0405
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0272 0.0272
Brugia malayi hypothetical protein 0.0072 0.1506 0.2275
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0732 0.1018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0215 0.0248
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0732 0.1307
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0072
Schistosoma mansoni flap endonuclease-1 0.0024 0.0356 0.0356
Schistosoma mansoni hypothetical protein 0.0016 0.0149 0.0149
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0557 0.1373
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0066 0.0153
Brugia malayi Protein cec-1. 0.0012 0.0052 0.0072
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0732 0.0994
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0732 0.0994
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.213 0.3708
Brugia malayi tailless protein 0.001 0.0005 0.0001
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0829 0.1127
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0005 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0732 0.0994
Echinococcus multilocularis peregrin 0.0012 0.0064 0.0064
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0732 0.1102
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.213 0.2904
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0193 0.0193
Brugia malayi glutaminase DH11.1 0.0284 0.6606 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0829 0.1127
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.0323 0.0435
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0237 0.0432
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0272 0.0272
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0044 0.0044
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0052 0.0072
Echinococcus multilocularis jun protein 0.0163 0.3695 0.3695
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0272 0.0272
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0732 0.181
Echinococcus multilocularis chromobox protein 1 0.0072 0.151 0.151
Schistosoma mansoni chromobox protein 0.0012 0.0052 0.0052
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0418 0.0922
Schistosoma mansoni cpg binding protein 0.0034 0.0574 0.0574
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0911 0.0911
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0911 0.0911
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.213 0.2904
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0433 0.0585
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0005 0.0001
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0034 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.213 0.3171
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0215 0.0248
Onchocerca volvulus 0.003 0.0485 0.0838
Echinococcus multilocularis bloom syndrome protein 0.0047 0.0901 0.0901
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0215 0.0248
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0237 0.0283
Trichomonas vaginalis rotamase, putative 0.0035 0.0602 0.084
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0041 0.0744 0.112
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0272 0.0272
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0272 0.0467
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0215 0.0248
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0235 0.0573
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0058 0.0072
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0005
Brugia malayi SET domain containing protein 0.0015 0.0122 0.0179
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0667 0.0667
Brugia malayi hypothetical protein 0.001 0.0005 0.0001
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0485 0.0728
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0141 0.0141
Echinococcus granulosus expressed protein 0.0035 0.0602 0.0602
Brugia malayi Nuclear hormone receptor E75 0.001 0.0005 0.0001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0052 0.00000000029463
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0044
Loa Loa (eye worm) hypothetical protein 0.004 0.0727 0.1094
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.0704 0.1739
Loa Loa (eye worm) hypothetical protein 0.0155 0.3504 0.5301
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0013 0.0075 0.0075
Trypanosoma cruzi ISWI complex protein 0.0016 0.0149 0.0198
Echinococcus multilocularis phosphoglycerate kinase 1 0.0177 0.4025 0.4025
Brugia malayi chromobox protein homolog 3 0.0041 0.0744 0.112
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0763 0.1791
Schistosoma mansoni chromobox protein 0.0072 0.151 0.151
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0177 0.4025 0.5
Schistosoma mansoni chromobox protein 0.0012 0.0052 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0058 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0235 0.0349
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0583 0.079
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0034 0.0044
Onchocerca volvulus 0.0128 0.2851 0.4967
Brugia malayi nuclear receptor RXR 0.0011 0.0034 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0983 0.0983
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0732 0.0994
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0272 0.0405
Loa Loa (eye worm) glutaminase 0.0284 0.6606 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0272 0.0272
Echinococcus granulosus chromobox protein 2 0.0012 0.0052 0.0052
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0005 0.0005
Brugia malayi hypothetical protein 0.0037 0.0667 0.1003
Brugia malayi Flap endonuclease-1 0.0027 0.0418 0.0626
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0177 0.4025 0.5493
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0072
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0272 0.0405
Schistosoma mansoni phd finger protein 0.0012 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0272 0.0405
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0005 0.0005
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0418 0.0565
Loa Loa (eye worm) hypothetical protein 0.0042 0.0786 0.1183
Trypanosoma brucei unspecified product 0.0028 0.0433 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0139 0.0133
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0237 0.0283
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0021 0.0272 0.0405

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 200 uM TNF-alpha production in PBMC by ELISA method ChEMBL. 8568809
IC50 (functional) > 200 uM TNF-alpha production in PBMC by ELISA method ChEMBL. 8568809

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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