Detailed information for compound 306500

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 466.017 | Formula: C23H36ClN5O3
  • H donors: 3 H acceptors: 2 LogP: 1.52 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC(C(=O)N1CCC(CC1)CN1CCC(CC1)NC(=O)c1cc(Cl)c(cc1OC)N)C
  • InChi: 1S/C23H36ClN5O3/c1-15(13-25)23(31)29-9-3-16(4-10-29)14-28-7-5-17(6-8-28)27-22(30)18-11-19(24)20(26)12-21(18)32-2/h11-12,15-17H,3-10,13-14,25-26H2,1-2H3,(H,27,30)
  • InChiKey: XKKCRENQKGZPBL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Serotonin 4 (5-HT4) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Get druggable targets OG5_133042 All targets in OG5_133042
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 4 (5-HT4) receptor   388 aa 326 aa 27.3 %
Echinococcus multilocularis allatostatin A receptor Serotonin 4 (5-HT4) receptor   388 aa 327 aa 26.3 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   388 aa 321 aa 24.0 %
Onchocerca volvulus Phospholipase d-related homolog Serotonin 4 (5-HT4) receptor   388 aa 404 aa 17.6 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   388 aa 357 aa 22.1 %
Echinococcus granulosus orexin receptor type 2 Serotonin 4 (5-HT4) receptor   388 aa 418 aa 22.5 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 4 (5-HT4) receptor   388 aa 363 aa 35.3 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Serotonin 4 (5-HT4) receptor   388 aa 352 aa 28.4 %
Echinococcus granulosus neuropeptide receptor Serotonin 4 (5-HT4) receptor   388 aa 325 aa 24.3 %
Echinococcus multilocularis dro:myosuppressin receptor Serotonin 4 (5-HT4) receptor   388 aa 360 aa 21.7 %
Loa Loa (eye worm) follicle stimulating hormone receptor Serotonin 4 (5-HT4) receptor   388 aa 345 aa 23.5 %
Brugia malayi Serotonin/octopamine receptor family protein 7 Serotonin 4 (5-HT4) receptor   388 aa 395 aa 29.4 %
Echinococcus granulosus thyrotropin releasing hormone receptor Serotonin 4 (5-HT4) receptor   388 aa 346 aa 20.8 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 4 (5-HT4) receptor   388 aa 395 aa 29.6 %
Brugia malayi GnHR receptor homolog Serotonin 4 (5-HT4) receptor   388 aa 358 aa 20.7 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   388 aa 361 aa 24.1 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   388 aa 315 aa 19.7 %
Echinococcus granulosus allatostatin A receptor Serotonin 4 (5-HT4) receptor   388 aa 359 aa 25.3 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   388 aa 367 aa 30.8 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 4 (5-HT4) receptor   388 aa 418 aa 22.7 %
Echinococcus granulosus somatostatin receptor Serotonin 4 (5-HT4) receptor   388 aa 375 aa 21.6 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Serotonin 4 (5-HT4) receptor   388 aa 374 aa 18.7 %
Echinococcus granulosus dro:myosuppressin receptor Serotonin 4 (5-HT4) receptor   388 aa 360 aa 21.7 %
Echinococcus multilocularis neuropeptide receptor Serotonin 4 (5-HT4) receptor   388 aa 325 aa 24.0 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Serotonin 4 (5-HT4) receptor   388 aa 346 aa 21.1 %
Schistosoma japonicum FMRFamide receptor, putative Serotonin 4 (5-HT4) receptor   388 aa 351 aa 19.9 %
Brugia malayi follicle stimulating hormone receptor Serotonin 4 (5-HT4) receptor   388 aa 319 aa 24.5 %
Schistosoma mansoni biogenic amine (5HT) receptor Serotonin 4 (5-HT4) receptor   388 aa 385 aa 31.9 %
Schistosoma mansoni peptide (allatostatin)-like receptor Serotonin 4 (5-HT4) receptor   388 aa 332 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0025 0.0019 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0531 0.1993
Schistosoma mansoni rab6-interacting 0.0021 0.0009 0.0009
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0114 0.0195 0.0708
Brugia malayi AKH receptor 0.0035 0.0038 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0038 0.0038
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0038 0.0072
Giardia lamblia Reverse transcriptase/endonuclease 0.0114 0.0195 0.072
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0297 0.0559 0.2097
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Schistosoma mansoni cpg binding protein 0.0029 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0038 0.0072
Plasmodium falciparum phd finger protein, putative 0.0028 0.0024 0.0313
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0009 0.0034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.006 0.0121
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0114 0.0195 0.072
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.002 0.002
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0424 0.0938
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Loa Loa (eye worm) hypothetical protein 0.0025 0.0019 0.0094
Echinococcus granulosus orexin receptor type 2 0.0035 0.0038 0.0072
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0114 0.0195 0.019
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0114 0.0195 0.019
Brugia malayi hypothetical protein 0.0035 0.0038 0.0132
Plasmodium vivax JmjC domain containing protein 0.0025 0.0019 0.0212
Schistosoma mansoni lipoxygenase 0.0086 0.0139 0.0139
Trichomonas vaginalis ribonuclease H1, putative 0.1345 0.2643 1
Echinococcus multilocularis neuropeptide receptor A26 0.0951 0.1859 0.4155
Loa Loa (eye worm) jmjC domain-containing protein 0.0097 0.0161 0.093
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0024 0.0126
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0036
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.0038 0.0072
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0007 0.0006
Schistosoma mansoni loxhd1 0.0021 0.0009 0.0009
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Schistosoma mansoni myosin xvIII 0.0035 0.0038 0.0038
Onchocerca volvulus 0.0035 0.0038 0.011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Echinococcus multilocularis dihydrofolate reductase 0.0086 0.0139 0.03
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Brugia malayi G-protein coupled receptor 0.0035 0.0038 0.0132
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0035 0.0038 0.0072
Schistosoma mansoni opsin-like receptor 0.0035 0.0038 0.0038
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0038 0.0072
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0019 0.0019
Onchocerca volvulus Alhambra homolog 0.0028 0.0024 0.0058
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0006 0.0016
Plasmodium falciparum importin beta, putative 0.0031 0.0031 0.0426
Onchocerca volvulus Ribonuclease H1 homolog 0.1345 0.2643 1
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0038 0.0072
Loa Loa (eye worm) TYRA-2 protein 0.0035 0.0038 0.0206
Brugia malayi Importin beta-1 subunit 0.0031 0.0031 0.0104
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.006 0.0214
Onchocerca volvulus 0.0035 0.0038 0.011
Echinococcus granulosus fmrfamide receptor 0.0035 0.0038 0.0072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.006 0.0121
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.006 0.0121
Schistosoma mansoni hypothetical protein 0.0035 0.0038 0.0038
Leishmania major cytochrome p450-like protein 0.0032 0.0031 0.0096
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.0083 0.0083
Schistosoma mansoni jumonji/arid domain-containing protein 0.0097 0.0161 0.0161
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.0744
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0531 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0114 0.0195 0.0426
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0038 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0531 0.1993
Echinococcus multilocularis RNA directed DNA polymerase 0.0114 0.0195 0.0426
Schistosoma mansoni alpha-1 adrenergic receptor 0.0035 0.0038 0.0038
Brugia malayi G protein-coupled receptor F59B2.13 0.0035 0.0038 0.0132
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0038 0.0072
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0114 0.0195 0.0426
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0048 0.0095
Schistosoma mansoni hypothetical protein 0.0171 0.0307 0.0307
Onchocerca volvulus 0.0035 0.0038 0.011
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0024 0.0042
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.0531 1
Echinococcus granulosus dro:myosuppressin receptor 0.0035 0.0038 0.0072
Echinococcus multilocularis neuropeptide s receptor 0.0951 0.1859 0.4155
Mycobacterium ulcerans thymidylate synthase 0.0211 0.0388 1
Brugia malayi hypothetical protein 0.0114 0.0195 0.0728
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0114 0.0195 0.0426
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0061 0.022
Leishmania major ribonuclease H1, putative 0.1345 0.2643 1
Trypanosoma cruzi ribonuclease H1, putative 0.1345 0.2643 1
Brugia malayi hypothetical protein 0.0021 0.0009 0.0022
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0035 0.0038 0.0206
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0009 0.0008
Echinococcus granulosus 7tm_1 domain containing protein 0.0035 0.0038 0.0072
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0035 0.0038 0.0038
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0019 0.0019
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0031 0.0165
Schistosoma mansoni protein kinase 0.0114 0.0195 0.0195
Echinococcus granulosus ribonuclease H1 0.1345 0.2643 0.5914
Brugia malayi hypothetical protein 0.0035 0.0038 0.0132
Echinococcus multilocularis fmrfamide receptor 0.0035 0.0038 0.0072
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0048 0.0161
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0038 0.0072
Schistosoma mansoni inositol monophosphatase 0.004 0.0048 0.0048
Brugia malayi Dopamine receptor 0.0035 0.0038 0.0132
Echinococcus multilocularis dro:myosuppressin receptor 0.0035 0.0038 0.0072
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0114 0.0195 0.0426
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0019 0.003
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0297 0.0559 0.2097
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0031 0.0095
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Echinococcus granulosus RNA directed DNA polymerase 0.0114 0.0195 0.0426
Schistosoma mansoni hypothetical protein 0.0035 0.0038 0.0038
Echinococcus granulosus 7TM GPCR rhodopsin 0.0035 0.0038 0.0072
Brugia malayi neuropeptide F receptor 0.0035 0.0038 0.0132
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Echinococcus multilocularis dnaJ subfamily B 0.0389 0.0741 0.1649
Brugia malayi hypothetical protein 0.0229 0.0424 0.1593
Brugia malayi Serotonin receptor 0.0035 0.0038 0.0132
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0038 0.0072
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0019 0.0019
Onchocerca volvulus 0.0035 0.0038 0.011
Onchocerca volvulus 0.0027 0.0022 0.0051
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0024 0.0042
Echinococcus granulosus peptide allatostatin:somatostatin 0.0035 0.0038 0.0072
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0114 0.0195 0.0426
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0114 0.0195 0.0426
Schistosoma mansoni ap endonuclease 0.002 0.0007 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0007 0.0006
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0007 0.0006
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Echinococcus multilocularis thymidylate synthase 0.0211 0.0388 0.0857
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.006 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0038 0.0038
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0045 0.0045
Echinococcus multilocularis g-protein coupled receptor 0.0035 0.0038 0.0072
Brugia malayi hypothetical protein 0.0035 0.0038 0.0132
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0531 0.1993
Loa Loa (eye worm) hypothetical protein 0.0163 0.0291 0.1698
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0114 0.0195 0.0426
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.002 0.0053
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.002 0.0062
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0154 0.0274 0.0601
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0114 0.0195 0.019
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0114 0.0195 0.0426
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0114 0.0195 0.0426
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0035 0.0038 0.0206
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0114 0.0195 0.0426
Loa Loa (eye worm) hypothetical protein 0.0163 0.0291 0.1698
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0035 0.0038 0.0072
Schistosoma mansoni hypothetical protein 0.0021 0.0009 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0019 0.0019
Brugia malayi Cytochrome P450 family protein 0.0032 0.0031 0.0105
Trypanosoma brucei ingi protein (ORF1) 0.1459 0.2871 0.2867
Loa Loa (eye worm) melatonin receptor type 1A 0.0035 0.0038 0.0206
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0211 0.0388 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0035 0.0038 0.0038
Brugia malayi Muscleblind-like protein 0.0163 0.0291 0.1092
Onchocerca volvulus 0.0035 0.0038 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Onchocerca volvulus 0.0035 0.0038 0.011
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0035 0.0038 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Schistosoma mansoni neuropeptide receptor 0.0035 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Onchocerca volvulus 0.0211 0.0388 0.1437
Echinococcus granulosus sex peptide receptor 0.0035 0.0038 0.0072
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0048 0.0809
Echinococcus granulosus microtubule associated protein 2 0.2261 0.4466 1
Loa Loa (eye worm) DnaJ domain-containing protein 0.013 0.0227 0.1322
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0048 0.0161
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0019 0.003
Brugia malayi reverse transcriptase 0.0114 0.0195 0.0728
Brugia malayi Tachykinin-like peptides receptor 99D 0.0035 0.0038 0.0132
Onchocerca volvulus 0.0035 0.0038 0.011
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0114 0.0195 0.0426
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0024 0.0024
Onchocerca volvulus 0.0114 0.0195 0.0708
Trypanosoma brucei hypothetical protein, conserved 0.1459 0.2871 0.2867
Echinococcus granulosus neuropeptide receptor 0.0035 0.0038 0.0072
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0019 0.003
Echinococcus granulosus RUN 0.0021 0.0009 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0038 0.0038
Entamoeba histolytica hypothetical protein 0.0026 0.002 0.0266
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0022 0.0036
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0114 0.0195 0.0426
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0048 0.0161
Mycobacterium tuberculosis Hypothetical protein 0.01 0.0168 0.4221
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0009 0.0008
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0012 0.0026
Brugia malayi RNase H family protein 0.1345 0.2643 1
Schistosoma mansoni hypothetical protein 0.0047 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0006 0.0006
Brugia malayi thymidylate synthase 0.0211 0.0388 0.1456
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Onchocerca volvulus 0.0035 0.0038 0.011
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.0634 0.3716
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0019 0.005
Echinococcus multilocularis lysine specific demethylase 5A 0.0095 0.0158 0.0341
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0038 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Schistosoma mansoni growth hormone secretagogue receptor 0.0035 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Brugia malayi hypothetical protein 0.0114 0.0195 0.0728
Schistosoma mansoni hypothetical protein 0.013 0.0227 0.0227
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0038 0.0072
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0084 0.0478
Schistosoma mansoni hypothetical protein 0.0114 0.0195 0.0195
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0297 0.0559 0.0553
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0019 0.0019
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0019 0.005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0035 0.0038 0.0038
Schistosoma mansoni jumonji/arid domain-containing protein 0.0097 0.0161 0.0161
Trypanosoma brucei ingi protein (ORF1) 0.1459 0.2871 0.2867
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0035 0.0038 0.0038
Brugia malayi Zinc knuckle family protein 0.0114 0.0195 0.0728
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0006 0.0009
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0038 0.0072
Schistosoma mansoni survival motor neuron protein 0.0047 0.0061 0.0061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.006 0.0335
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Brugia malayi hypothetical protein 0.0035 0.0038 0.0132
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0035 0.0038 0.0132
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0048 0.0161
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Loa Loa (eye worm) inositol-1 0.004 0.0048 0.0266
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0038 0.0038
Echinococcus granulosus importin subunit beta 1 0.0031 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0297 0.0559 1
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0046 0.0091
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0038 0.0072
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0035 0.0038 0.0072
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.0038 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Schistosoma mansoni biogenic amine receptor 0.0035 0.0038 0.0038
Echinococcus granulosus cpg binding protein 0.0029 0.0026 0.0045
Schistosoma mansoni opsin-like receptor 0.0035 0.0038 0.0038
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0031 0.0165
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0035 0.0038 0.0072
Echinococcus granulosus g protein coupled receptor 0.0035 0.0038 0.0072
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0019 0.005
Schistosoma mansoni importin beta-1 0.0031 0.0031 0.0031
Toxoplasma gondii exonuclease III APE 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Echinococcus granulosus g protein coupled receptor 0.0035 0.0038 0.0072
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0114 0.0195 0.072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0035 0.0038 0.0132
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0007 0.0006
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0019 0.003
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0024 0.0313
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0531 0.1993
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0114 0.0195 0.0195
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.002 0.0014
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0035 0.0038 0.0072
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.0038 0.0072
Brugia malayi Zinc knuckle family protein 0.0114 0.0195 0.0728
Echinococcus multilocularis RUN 0.0021 0.0009 0.0008
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0031 0.0025
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0019 0.003
Brugia malayi hypothetical protein 0.0035 0.0038 0.0132
Echinococcus multilocularis G protein coupled receptor 139 0.0035 0.0038 0.0072
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0243 0.585
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0038 0.0038
Schistosoma mansoni lipoxygenase 0.0123 0.0212 0.0212
Brugia malayi Melatonin receptor type 1A 0.0035 0.0038 0.0132
Echinococcus granulosus dnaJ subfamily B 0.0389 0.0741 0.1649
Trichomonas vaginalis reverse transcriptases, putative 0.0114 0.0195 0.072
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.01 0.0168 0.0615
Schistosoma mansoni phosphoglucomutase 0.1345 0.2643 0.2643
Brugia malayi larval opioid receptor 0.0035 0.0038 0.0132
Brugia malayi dihydrofolate reductase family protein 0.0086 0.0139 0.0516
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0086 0.0139 0.3472
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.0038 0.0072
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0048 0.0161
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Loa Loa (eye worm) thymidylate synthase 0.0211 0.0388 0.2264
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.002 0.0031
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0114 0.0195 0.0426
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0243 0.6206
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0038 0.0072
Onchocerca volvulus 0.0035 0.0038 0.011
Toxoplasma gondii FATC domain-containing protein 0.0026 0.002 0.0053
Brugia malayi Dopamine receptor protein 2 0.0035 0.0038 0.0132
Entamoeba histolytica hypothetical protein 0.0025 0.0019 0.0251
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0024 0.0071
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0007 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.006 0.006
Giardia lamblia PHD finger protein 15 0.0028 0.0024 0.0071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0531 0.1993
Schistosoma mansoni histamine h1 receptor 0.0035 0.0038 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0019 0.0094
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0038 0.0072
Onchocerca volvulus 0.0114 0.0195 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0168 0.0615
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.006 0.0121
Echinococcus granulosus lysine specific demethylase 5A 0.0097 0.0161 0.0348
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0297 0.0559 1
Toxoplasma gondii ribonuclease HI protein 0.1345 0.2643 1
Schistosoma mansoni hypothetical protein 0.0114 0.0195 0.0195
Brugia malayi putative neuropeptide receptor NPR1 0.0035 0.0038 0.0132
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Trypanosoma brucei unspecified product 0.1459 0.2871 0.2867
Schistosoma mansoni biogenic amine receptor 0.0035 0.0038 0.0038
Schistosoma mansoni amine GPCR 0.0035 0.0038 0.0038
Echinococcus granulosus g protein coupled receptor 0.0035 0.0038 0.0072
Echinococcus multilocularis G-protein coupled receptor, putative 0.0035 0.0038 0.0072
Brugia malayi reverse transcriptase 0.0114 0.0195 0.0728
Echinococcus granulosus peregrin 0.0028 0.0024 0.0042
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0022 0.0115
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.0744
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0065 0.0097 0.0553
Trichomonas vaginalis reverse transcriptases, putative 0.0114 0.0195 0.072
Echinococcus multilocularis sex peptide receptor 0.0035 0.0038 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0038 0.0072
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0035 0.0038 0.0132
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0038 0.0206
Schistosoma mansoni microtubule-associated protein tau 0.2261 0.4466 0.4466
Brugia malayi Dopamine receptor protein 1 0.0035 0.0038 0.0132
Trypanosoma cruzi ribonuclease H1, putative 0.1345 0.2643 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0035 0.0038 0.0132
Schistosoma mansoni neuropeptide f receptor 76f 0.0035 0.0038 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.002 0.0053
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Loa Loa (eye worm) dihydrofolate reductase 0.0086 0.0139 0.0802
Echinococcus granulosus snurportin 1 0.0335 0.0634 0.141
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0048 0.1078
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0007 0.0015
Echinococcus granulosus serine protein kinase ATM 0.0026 0.002 0.0031
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0031 0.0025
Schistosoma mansoni neuropeptide receptor 0.0035 0.0038 0.0038
Schistosoma mansoni neuropeptide receptor 0.0035 0.0038 0.0038
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0114 0.0195 0.0426
Brugia malayi Serotonin receptor 0.0035 0.0038 0.0132
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0019 0.005
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0031 0.0096
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.0038 0.0206
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0036
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0019 0.005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0007 0.0028
Brugia malayi hypothetical protein 0.0035 0.0038 0.0132
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0031 0.0625
Echinococcus granulosus phd:f box containing protein 0.0025 0.0019 0.003
Onchocerca volvulus 0.0035 0.0038 0.011
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0048 0.0161
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0031 0.0096
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0038 0.0038
Schistosoma mansoni dihydrofolate reductase 0.0086 0.0139 0.0139
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0031 0.0165
Schistosoma mansoni hypothetical protein 0.0389 0.0741 0.0741
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0006 0.0009
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.0038 0.0072
Brugia malayi Cytochrome P450 family protein 0.0032 0.0031 0.0105
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0019 0.0212
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.0038 0.0072
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.1345 0.2643 1
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.0038 0.0038
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0019 0.005
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0035 0.0038 0.0072
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0019 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Brugia malayi hypothetical protein 0.0114 0.0195 0.0728
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0035 0.0038 0.0206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0038 0.0038
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0114 0.0195 0.072
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0009 0.0036
Trypanosoma brucei ribonuclease H1 0.1345 0.2643 0.2639
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0019 0.005
Schistosoma mansoni adenoreceptor 0.0035 0.0038 0.0038
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0035 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0056
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0038 0.0206
Echinococcus granulosus neuropeptide receptor A26 0.0951 0.1859 0.4155
Brugia malayi hypothetical protein 0.0021 0.0009 0.0022
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0024 0.0071
Echinococcus granulosus muscleblind protein 0.0163 0.0291 0.0641
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0038 0.0072
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0022 0.0036
Schistosoma mansoni cpg binding protein 0.0029 0.0026 0.0026
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0019 0.0094
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0019 0.003
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Echinococcus multilocularis serotonin receptor 0.0035 0.0038 0.0072
Onchocerca volvulus 0.0035 0.0038 0.011
Brugia malayi hypothetical protein 0.01 0.0168 0.0624
Echinococcus multilocularis snurportin 1 0.0335 0.0634 0.141
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.0038 0.0038
Schistosoma mansoni ap endonuclease 0.002 0.0007 0.0007
Echinococcus multilocularis muscleblind protein 1 0.0163 0.0291 0.0641
Schistosoma mansoni jumonji domain containing protein 0.0135 0.0236 0.0236
Echinococcus multilocularis allatostatin A receptor 0.0035 0.0038 0.0072
Chlamydia trachomatis dihydrofolate reductase 0.0086 0.0139 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0038 0.0038
Onchocerca volvulus 0.0035 0.0038 0.011
Echinococcus granulosus tachykinin peptides receptor 99D 0.0035 0.0038 0.0072
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0086 0.0139 0.3472
Schistosoma mansoni cpg binding protein 0.0027 0.0022 0.0022
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.0531 0.1993
Schistosoma mansoni rab6-interacting 0.0021 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.0744
Toxoplasma gondii histone lysine methyltransferase SET1 0.0052 0.0071 0.0248
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0007 0.0003
Plasmodium vivax importin-beta 2, putative 0.0031 0.0031 0.0426
Schistosoma mansoni hypothetical protein 0.0038 0.0045 0.0045
Schistosoma mansoni amine GPCR 0.0035 0.0038 0.0038
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Schistosoma mansoni hypothetical protein 0.0335 0.0634 0.0634
Echinococcus granulosus KRAB A domain containing protein 0.0114 0.0195 0.0426
Echinococcus multilocularis microtubule associated protein 2 0.2261 0.4466 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0019 0.0094
Echinococcus granulosus neuropeptide receptor 0.0035 0.0038 0.0072
Brugia malayi putative neuropeptide receptor 0.0035 0.0038 0.0132
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0114 0.0195 0.072
Echinococcus multilocularis neuropeptide FF receptor 2 0.0035 0.0038 0.0072
Echinococcus granulosus somatostatin receptor 0.0035 0.0038 0.0072
Brugia malayi hypothetical protein 0.0035 0.0038 0.0132
Brugia malayi DnaJ domain containing protein 0.013 0.0227 0.085
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0009 0.0008
Onchocerca volvulus 0.0035 0.0038 0.011
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Echinococcus multilocularis cpg binding protein 0.0029 0.0026 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.0212 0.0463
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.1459 0.2871 0.2867
Echinococcus granulosus dihydrofolate reductase 0.0086 0.0139 0.03
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0035 0.0038 0.011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0038 0.0072
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0243 0.6206
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0531 0.1993
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.0038 0.0206
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Echinococcus multilocularis peregrin 0.0028 0.0024 0.0042
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0038 0.0038
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0114 0.0195 0.072
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0035 0.0038 0.0132
Echinococcus granulosus geminin 0.0171 0.0307 0.0677
Echinococcus multilocularis g protein coupled receptor 0.0035 0.0038 0.0072
Echinococcus multilocularis neuropeptide receptor 0.0035 0.0038 0.0072
Brugia malayi Bromodomain containing protein 0.0028 0.0024 0.008
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0035 0.0038 0.0038
Giardia lamblia Ribonuclease H 0.1345 0.2643 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0031 0.0163
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0035 0.0038 0.0072
Brugia malayi hypothetical protein 0.0035 0.0038 0.0132
Schistosoma mansoni hypothetical protein 0.0035 0.0038 0.0038
Echinococcus multilocularis orexin receptor type 2 0.0035 0.0038 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Schistosoma mansoni phosphoglucomutase 0.1345 0.2643 0.2643
Onchocerca volvulus 0.0035 0.0038 0.011
Echinococcus multilocularis serotonin receptor 0.0035 0.0038 0.0072
Brugia malayi follicle stimulating hormone receptor 0.0035 0.0038 0.0132
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0424 0.0938
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.0038 0.0072
Schistosoma mansoni hypothetical protein 0.0035 0.0038 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0019 0.0094
Onchocerca volvulus 0.0047 0.0061 0.0198
Echinococcus multilocularis somatostatin receptor 0.0035 0.0038 0.0072
Brugia malayi reverse transcriptase 0.0114 0.0195 0.0728
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0531 0.1993
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.0212 0.0463
Trichomonas vaginalis protein kinase inhibitor, putative 0.013 0.0227 0.0841
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0035 0.0038 0.0072
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0297 0.0559 0.2097
Treponema pallidum ribonuclease H (rnhA) 0.1345 0.2643 1
Brugia malayi Inositol-1 0.004 0.0048 0.017
Brugia malayi ORL1-like opioid receptor 0.0035 0.0038 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0038 0.0038
Schistosoma mansoni phosphoglucomutase 0.1345 0.2643 0.2643
Echinococcus granulosus dnaJ subfamily C 6 0.013 0.0227 0.0497
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0007 0.0006
Brugia malayi RE15519p 0.0035 0.0038 0.0132
Echinococcus granulosus allatostatin A receptor 0.0035 0.0038 0.0072
Brugia malayi jmjC domain containing protein 0.0154 0.0274 0.1025
Schistosoma mansoni opsin-like receptor 0.0035 0.0038 0.0038
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0045 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0086 0.0139 0.286
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0211 0.0388 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0035 0.0038 0.0038
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0019 0.003
Schistosoma mansoni inositol monophosphatase 0.004 0.0048 0.0048
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0035 0.0038 0.0072
Brugia malayi G-protein coupled receptor 0.0035 0.0038 0.0132
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0126
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Echinococcus multilocularis dnaJ subfamily C 6 0.013 0.0227 0.0497
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Brugia malayi GnHR receptor homolog 0.0035 0.0038 0.0132
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Echinococcus multilocularis geminin 0.0171 0.0307 0.0677
Brugia malayi neuropeptide F receptor 0.0035 0.0038 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Leishmania major importin beta-1 subunit, putative 0.0025 0.0019 0.005
Echinococcus granulosus serotonin receptor 0.0035 0.0038 0.0072
Brugia malayi RNA, U transporter 1 0.0089 0.0146 0.054
Brugia malayi RNase H family protein 0.1345 0.2643 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0035 0.0038 0.0072
Brugia malayi jmjC domain containing protein 0.0025 0.0019 0.0059
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Brugia malayi hypothetical protein 0.0035 0.0038 0.0132
Echinococcus granulosus g-protein coupled receptor 0.0035 0.0038 0.0072
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0048 0.0095
Brugia malayi hypothetical protein 0.0114 0.0195 0.0728
Brugia malayi RNase H family protein 0.1345 0.2643 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0035 0.0038 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.0038 0.0038
Brugia malayi G protein-coupled receptor 0.0035 0.0038 0.0132
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.004 0.0858
Schistosoma mansoni amine GPCR 0.0035 0.0038 0.0038
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0046 0.0091
Schistosoma mansoni hypothetical protein 0.0171 0.0307 0.0307
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0211 0.0388 0.0388
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0195 0.0195
Brugia malayi PHD-finger family protein 0.0028 0.0024 0.008
Trypanosoma brucei RNA helicase, putative 0.5043 1 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Brugia malayi hypothetical protein 0.0872 0.1702 0.6436
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0045 0.0088
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0114 0.0195 0.072
Brugia malayi Dihydrofolate reductase 0.0086 0.0139 0.0516
Loa Loa (eye worm) hypothetical protein 0.0872 0.1702 1
Schistosoma mansoni polycystin 1-related 0.0021 0.0009 0.0009
Schistosoma mansoni neuropeptide receptor 0.0035 0.0038 0.0038
Echinococcus granulosus hypothetical protein 0.0035 0.0038 0.0072
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0007 0.0001
Schistosoma mansoni biogenic amine receptor 0.0035 0.0038 0.0038
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0035 0.0038 0.0038
Schistosoma mansoni amine GPCR 0.0035 0.0038 0.0038
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.0038 0.0038
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.0531 0.1988
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0019 0.005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Echinococcus granulosus thymidylate synthase 0.0211 0.0388 0.0857
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0048 0.0043
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0154 0.0274 0.0601
Onchocerca volvulus Neuropeptide F receptor homolog 0.0035 0.0038 0.011
Brugia malayi Pao retrotransposon peptidase family protein 0.0114 0.0195 0.0728
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.006 0.006
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0048 0.0161
Leishmania major hypothetical protein, conserved 0.0025 0.0019 0.005
Brugia malayi Doublecortin family protein 0.0021 0.0009 0.0022
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0035 0.0038 0.0206
Echinococcus multilocularis ribonuclease H1 0.1345 0.2643 0.5914
Onchocerca volvulus 0.0035 0.0038 0.011
Echinococcus multilocularis muscleblind protein 0.0163 0.0291 0.0641
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.0531 0.1993
Onchocerca volvulus 0.0035 0.0038 0.011
Brugia malayi jmjC domain containing protein 0.0097 0.0161 0.0598
Brugia malayi CXXC zinc finger family protein 0.0027 0.0022 0.0073
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0048 0.0156
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0007 0.0003
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0035 0.0038 0.0206
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0035 0.0038 0.0072
Mycobacterium tuberculosis Possible maturase 0.0114 0.0195 0.4949
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.0038 0.0072
Brugia malayi sulfakinin receptor protein 0.0872 0.1702 0.6436
Echinococcus granulosus neuropeptide s receptor 0.0951 0.1859 0.4155
Echinococcus granulosus alpha 1A adrenergic receptor 0.0035 0.0038 0.0072
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0009 0.0034
Echinococcus granulosus G protein coupled receptor 139 0.0035 0.0038 0.0072
Entamoeba histolytica hypothetical protein 0.0038 0.0045 0.0744
Brugia malayi hypothetical protein 0.0038 0.0045 0.0157
Schistosoma mansoni hypothetical protein 0.0028 0.0024 0.0024
Schistosoma mansoni amine GPCR 0.0035 0.0038 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0195 0.072
Brugia malayi jmjC domain containing protein 0.0025 0.0019 0.0059
Onchocerca volvulus 0.0035 0.0038 0.011
Loa Loa (eye worm) hypothetical protein 0.0229 0.0424 0.2477
Brugia malayi jmjC domain containing protein 0.0025 0.0019 0.0059
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.0038 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.0038 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0206

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.08 nM Inhibitory activity against 5-hydroxytryptamine 4 receptor of guinea pig striatum using [3H]-GR-113,808 as radioligand ChEMBL. 11959005
IC50 (binding) = 5.08 nM Inhibitory activity against 5-hydroxytryptamine 4 receptor of guinea pig striatum using [3H]-GR-113,808 as radioligand ChEMBL. 11959005
Stomach (functional) = 121 % Gastrointestinal motility was reported after intravenous administration at a dose 1 mg/kg to dogs in stomach ChEMBL. 11959005

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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