Detailed information for compound 31190

Basic information

Technical information
  • TDR Targets ID: 31190
  • Name: 2-phenyl-3,1-benzoxazin-4-one
  • MW: 223.227 | Formula: C14H9NO2
  • H donors: 0 H acceptors: 1 LogP: 2.93 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1oc(nc2c1cccc2)c1ccccc1
  • InChi: 1S/C14H9NO2/c16-14-11-8-4-5-9-12(11)15-13(17-14)10-6-2-1-3-7-10/h1-9H
  • InChiKey: HTTLBYITFHMYFK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1022-46-4
  • AI3-61952
  • NSC 16082
  • ChemDiv2_003515
  • 2-Phenyl-benzo[d][1,3]oxazin-4-one
  • 37872_RIEDEL
  • 2-Phenyl-3,1-benzoxazinone-(4)
  • 4H-3,1-Benzoxazin-4-one, 2-phenyl-
  • Bentranil
  • H-170
  • Linarotox
  • Linurotox
  • NSC16082
  • WLN: T66 BVO ENJ DR
  • Oprea1_579311
  • A0654/0030383
  • Maybridge1_006945
  • EU-0066816
  • CBDivE_001429
  • ZINC00094053
  • BAS 04934212

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens elastase, neutrophil expressed Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus transmembrane protease serine 3 elastase, neutrophil expressed 267 aa 236 aa 27.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0084 0.0084
Leishmania major importin beta-1 subunit, putative 0.0023 0.009 0.0071
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0012 0.0012
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0012 0.0012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0082 0.0082
Brugia malayi hypothetical protein 0.0073 0.0422 0.0422
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0076 0.0056
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0022 0.0084 0.0671
Trypanosoma cruzi adenosine kinase, putative 0.1503 1 1
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0084 0.0084
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0084 0.0084
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0012 0.00000000082332
Echinococcus multilocularis lamin dm0 0.0032 0.0145 0.0145
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0082 0.0082
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0333 0.0333
Entamoeba histolytica ribokinase, putative 0.0171 0.1081 1
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0019 0.0061 0.0042
Schistosoma mansoni ribokinase 0.0171 0.1081 0.1081
Leishmania major histone-lysine N-methyltransferase, putative 0.0019 0.0061 0.0042
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0148 0.0148
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0084 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0082 0.0082
Brugia malayi Heterochromatin protein 1 0.0072 0.0413 0.0413
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0012 0.0012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0012 0.00000000015615
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0145 0.0145
Onchocerca volvulus 0.0012 0.0012 0.0009
Echinococcus granulosus intermediate filament protein 0.0032 0.0145 0.0145
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0409 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0084 0.0408
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0409 0.0409
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.015 0.0939 0.0939
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0948 0.6287 0.6287
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0032 0.0148 0.0148
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0044 0.0044
Brugia malayi MH2 domain containing protein 0.0017 0.0044 0.0044
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0012 0.0012
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0084 0.0084
Schistosoma mansoni nuclear hormone receptor 0.001 0.0004 0.0004
Onchocerca volvulus 0.0056 0.0311 0.0348
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0084 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0087 0.0087
Schistosoma mansoni smad1 5 8 and 0.0017 0.0044 0.0044
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0084 0.0084
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0076 0.0076
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0076 0.1921
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Echinococcus multilocularis ribokinase 0.0171 0.1081 0.1081
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0076 0.0056
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0082 0.0082
Brugia malayi hypothetical protein 0.0277 0.1786 0.1786
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0019 0.0061 0.0042
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0145 0.0145
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0102 0.0616 0.0691
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0084 0.0084
Trypanosoma brucei protein kinase, putative 0.006 0.0333 0.0314
Echinococcus multilocularis survival motor neuron protein 1 0.0277 0.1786 0.1786
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0148 0.0148
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0044 0.0044
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0069 0.0397 0.0397
Echinococcus multilocularis expressed protein 0.0437 0.2858 0.2858
Echinococcus multilocularis snurportin 1 0.0308 0.1999 0.1999
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0082
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.1081 0.6085
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0084 0.0084
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0409 0.0409
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0148 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.1503 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0004 0.0004
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0004 0.0004
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0019 0.0061 0.0042
Trichomonas vaginalis importin beta-1, putative 0.0023 0.009 0.0447
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0333 0.1827
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0082 0.0082
Brugia malayi SET domain containing protein 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0084 0.0084
Entamoeba histolytica heat shock transcription factor, putative 0.0102 0.0616 0.5649
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0148 0.0148
Leishmania major tagatose-6-phosphate kinase-like protein 0.0171 0.1081 0.1063
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0012 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0082 0.0082
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0171 0.1081 0.1081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0004 0.0004
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0084 0.0084
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0012 0.00000000015615
Schistosoma mansoni smad1 5 8 and 0.0017 0.0044 0.0044
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0276 0.793
Brugia malayi hypothetical protein 0.0012 0.0012 0.0012
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0223 0.1199
Echinococcus granulosus smad 0.0017 0.0044 0.0044
Entamoeba histolytica heat shock transcription factor, putative 0.0102 0.0616 0.5649
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.009 0.0447
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0124 0.0636
Trichomonas vaginalis glutaminase, putative 0.0274 0.1768 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0084 0.0084
Echinococcus granulosus survival motor neuron protein 1 0.0277 0.1786 0.1786
Schistosoma mansoni programmed cell death protein 0.0061 0.0345 0.0345
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0032 0.0145 0.0145
Schistosoma mansoni ran 0.0021 0.0076 0.0076
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0276 0.0276
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0148 0.0148
Schistosoma mansoni programmed cell death protein 0.0061 0.0345 0.0345
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0082 0.0082
Schistosoma mansoni chromobox protein 0.0012 0.0012 0.0012
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0012 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.009 0.0447
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0082 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0082 0.0082
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0012 0.0346
Schistosoma mansoni hypothetical protein 0.0032 0.0148 0.0148
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0409 0.2799
Schistosoma mansoni hypothetical protein 0.0032 0.0148 0.0148
Toxoplasma gondii kinase, pfkB family protein 0.0171 0.1081 0.1081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0035
Leishmania major GTP-binding protein, putative 0.0021 0.0076 0.0056
Loa Loa (eye worm) hypothetical protein 0.0022 0.0084 0.0084
Trypanosoma cruzi ribokinase, putative 0.0171 0.1081 0.1063
Loa Loa (eye worm) glutaminase 2 0.0274 0.1768 0.1768
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0171 0.1081 1
Loa Loa (eye worm) Smad1 0.0017 0.0044 0.0044
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0611 0.0611
Brugia malayi CHD4 protein 0.0012 0.0012 0.0012
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0148 0.4296
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Mycobacterium leprae Probable adenosine kinase adk 0.0171 0.1081 0.5
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0333 0.0333
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0087 0.0087
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0308 0.1999 0.1999
Plasmodium falciparum importin beta, putative 0.0029 0.0127 0.3681
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0004 0.0004
Schistosoma mansoni adenosine kinase 0.1503 1 1
Echinococcus granulosus Chromobox protein 3 0.0012 0.0012 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0082 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0012 0.00000000015615
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0095 0.0471
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Leishmania major putative PfkB family sugar kinase 0.0171 0.1081 0.1063
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0084 0.0084
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0084 0.0084
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0333 0.0333
Schistosoma mansoni hypothetical protein 0.0073 0.0422 0.0422
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0223 0.1199
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0004 0.0004
Brugia malayi conserved hypotetical protein 0.001 0.0004 0.0004
Echinococcus granulosus histone h3 methyltransferase 0.015 0.0939 0.0939
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0171 0.1081 1
Schistosoma mansoni hypothetical protein 0.0344 0.2236 0.2236
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0145 0.0145
Plasmodium vivax importin-beta 2, putative 0.0029 0.0127 0.3455
Schistosoma mansoni hypothetical protein 0.0032 0.0148 0.0148
Echinococcus multilocularis Smad4 0.0017 0.0044 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0333 0.1827
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0082 0.0082
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0012 0.0012
Schistosoma mansoni chromobox protein 0.0072 0.0413 0.0413
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0035 0.0035
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0041 0.0041
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0171 0.1081 1
Brugia malayi ecdysone receptor 0.001 0.0004 0.0004
Brugia malayi nuclear receptor RXR 0.001 0.0004 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0148 0.0148
Entamoeba histolytica hypothetical protein 0.0073 0.0422 0.3841
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0121 0.0744 0.0744
Echinococcus multilocularis musashi 0.0032 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0101 0.0611 0.0611
Onchocerca volvulus 0.1332 0.8853 1
Brugia malayi nuclear receptor RXR 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0171 0.1081 0.1081
Onchocerca volvulus Putative pyridoxal kinase 0.0171 0.1081 0.1217
Entamoeba histolytica recQ family helicase, putative 0.0013 0.002 0.0071
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0076 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0333 0.1827
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0082
Echinococcus granulosus bloom syndrome protein 0.0024 0.0095 0.0095
Echinococcus granulosus ribokinase 0.0171 0.1081 0.1081
Onchocerca volvulus 0.0031 0.0144 0.0159
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0082
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0344 0.2236 0.2236
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0082 0.0082
Leishmania major adenosine kinase-like protein 0.0171 0.1081 0.1063
Echinococcus multilocularis programmed cell death protein 4 0.0061 0.0345 0.0345
Brugia malayi Protein cec-1. 0.0012 0.0012 0.0012
Brugia malayi hypothetical protein 0.0051 0.0276 0.0276
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0148 0.0148
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0012 0.0012
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0413 0.2282
Loa Loa (eye worm) hypothetical protein 0.0102 0.0616 0.0616
Mycobacterium tuberculosis Ribokinase RbsK 0.0171 0.1081 1
Brugia malayi chromobox protein homolog 3 0.004 0.0202 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0082 0.0082
Entamoeba histolytica hypothetical protein 0.0073 0.0422 0.3841
Trichomonas vaginalis ribokinase, putative 0.0171 0.1081 0.6085
Schistosoma mansoni Smad4 0.0017 0.0044 0.0044
Toxoplasma gondii kinase, pfkB family protein 0.1503 1 1
Echinococcus granulosus Smad4 0.0017 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Toxoplasma gondii hypothetical protein 0.0019 0.0061 0.0061
Brugia malayi MH2 domain containing protein 0.0242 0.1556 0.1556
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0082 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0082 0.0082
Brugia malayi HSF-type DNA-binding domain containing protein 0.0102 0.0616 0.0616
Leishmania major tagatose-6-phosphate kinase-like protein 0.0171 0.1081 0.1063
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0012 0.0012
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0148 0.0148
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0084 0.0084
Echinococcus granulosus Chromo domain 0.0012 0.0012 0.0012
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0082 0.0082
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0276 0.0257
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0333 0.0314
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0333 0.0314
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0082 0.0082
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0004 0.0004
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0015 0.0032 0.0032
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0012 0.0012
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0333 0.0314
Schistosoma mansoni lamin 0.0032 0.0145 0.0145
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0019 0.0061 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0012 0.00000000015615
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0082 0.0082
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0084 0.0084
Echinococcus multilocularis histone h3 methyltransferase 0.015 0.0939 0.0939
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0044 0.0044
Onchocerca volvulus 0.0171 0.1081 0.1217
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0047 0.0047
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0082 0.0082
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0069 0.0397 0.0397
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0148 0.0129
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0082 0.0082
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0422 0.0422
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0084 0.0084
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0095 0.0095
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0127 0.0127
Schistosoma mansoni histone J3 methyltransferase 0.015 0.0939 0.0939
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0012 0.0012
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.009 0.0071
Entamoeba histolytica hypothetical protein 0.0012 0.0012 0.00000000025662
Onchocerca volvulus 0.0032 0.0145 0.0159
Schistosoma mansoni glutaminase 0.0274 0.1768 0.1768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0082 0.0082
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0148 0.0148
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0171 0.1081 0.494
Loa Loa (eye worm) hypothetical protein 0.0171 0.1081 0.1081
Echinococcus multilocularis GPCR, family 2 0.0032 0.0148 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0084 0.0408
Onchocerca volvulus Ribokinase homolog 0.0171 0.1081 0.1217
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0082 0.0082
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0202 0.1083
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0082 0.0089
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0148 0.0129
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0012 0.00000000015615
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0082 0.0082
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0148 0.0148
Entamoeba histolytica Ran family GTPase 0.0021 0.0076 0.0599
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0409 0.0409
Mycobacterium ulcerans fructokinase, PfkB 0.0171 0.1081 0.494
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0012 0.00000000015615
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0171 0.1081 0.1081
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Trichomonas vaginalis ribokinase, putative 0.0171 0.1081 0.6085
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0004 0.0004
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0047 0.0047
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.1556 0.1556
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0012 0.00000000015615
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0082 0.0082
Brugia malayi Nuclear hormone receptor E75 0.001 0.0004 0.0004
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0044 0.0044
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0276 0.8001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0082 0.0082
Leishmania major hypothetical protein, conserved 0.0019 0.0061 0.0042
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0082 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0012 0.00000000015615
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0012 0.00000000015615
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0087 0.0087
Brugia malayi Ribokinase 0.0171 0.1081 0.1081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0082 0.0082
Trichomonas vaginalis ran, putative 0.0021 0.0076 0.0364
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0084 0.0084
Loa Loa (eye worm) DR-78 0.001 0.0004 0.0004
Echinococcus granulosus chromobox protein 1 0.0072 0.0413 0.0413
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0082 0.0082
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0087 0.0087
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0012 0.00000000025662
Trypanosoma brucei histone-lysine n-methyltransferase 0.0019 0.0061 0.0042
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0148 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0084 0.0408
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0084 0.0084
Entamoeba histolytica hypothetical protein 0.0023 0.009 0.0734
Echinococcus multilocularis smad 0.0017 0.0044 0.0044
Brugia malayi isocitrate dehydrogenase 0.0032 0.0148 0.0148
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0084 0.0084
Echinococcus granulosus chromobox protein 2 0.0012 0.0012 0.0012
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0076 0.0056
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0148 0.0148
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0276 0.8001
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0004 0.0004
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0202 0.0224
Schistosoma mansoni survival motor neuron protein 0.0056 0.0311 0.0311
Brugia malayi hypothetical protein 0.0022 0.0084 0.0084
Brugia malayi Importin beta-1 subunit 0.0029 0.0127 0.0127
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0333 0.0333
Brugia malayi hypothetical protein 0.0012 0.0012 0.0012
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0333 0.0314
Loa Loa (eye worm) hypothetical protein 0.0022 0.0084 0.0084
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0012 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0012 0.0012
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0148 0.4091
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0082
Echinococcus granulosus snurportin 1 0.0308 0.1999 0.1999
Trypanosoma cruzi adenosine kinase, putative 0.0171 0.1081 0.1063
Brugia malayi Nuclear hormone receptor E75 0.001 0.0004 0.0004
Schistosoma mansoni chromobox protein 0.0072 0.0413 0.0413
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0044 0.0044
Entamoeba histolytica heat shock transcription factor, putative 0.0102 0.0616 0.5649
Trypanosoma brucei adenosine kinase, putative 0.1503 1 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0087 0.0087
Toxoplasma gondii MA3 domain-containing protein 0.0061 0.0345 0.0345
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0084 0.0408
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Entamoeba histolytica fructokinase, putative 0.0171 0.1081 1
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0019 0.0061 0.0042
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0004 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0082 0.0082
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0004 0.0004
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0084 0.0084
Schistosoma mansoni coup transcription factor 0.0022 0.0082 0.0082
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0333 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0022 0.0084 0.0671
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0127 0.0127
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0084 0.0084
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0333 0.3079
Echinococcus granulosus GPCR family 2 0.0032 0.0148 0.0148
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0042 0.0915
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0082 0.0082
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0076 0.0076
Echinococcus multilocularis chromobox protein 1 0.0072 0.0413 0.0413
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0277 0.1786 0.1786
Giardia lamblia Ribokinase 0.0171 0.1081 1
Brugia malayi hypothetical protein 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0084 0.0084
Brugia malayi MH1 domain containing protein 0.0017 0.0044 0.0044
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0044 0.0044
Schistosoma mansoni adenosine kinase 0.1503 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0397 0.0397
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0311 0.0311
Echinococcus granulosus lamin dm0 0.0032 0.0145 0.0145
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0082 0.0082
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0611 0.0611
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0012 0.00000000025662
Loa Loa (eye worm) helicase 0.0012 0.0012 0.0012
Trypanosoma brucei ribokinase, putative 0.0171 0.1081 0.1063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0082 0.0082
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0276 0.0257
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0084 0.0084
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0032 0.0032
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0012 0.0346
Echinococcus granulosus chromobox protein 1 0.0072 0.0413 0.0413
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0084 0.0408
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0076 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0082 0.0082
Schistosoma mansoni nuclear receptor 0.001 0.0004 0.0004
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0095 0.0471
Schistosoma mansoni chromobox protein 0.0012 0.0012 0.0012
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0012 0.0012
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0084 0.0084
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0084 0.0084
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0084 0.0084
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0012 0.0012 0.0012
Brugia malayi MH1 domain containing protein 0.0017 0.0044 0.0044
Schistosoma mansoni smad1 5 8 and 0.0017 0.0044 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0082 0.0082
Brugia malayi nuclear receptor NHR-67 0.001 0.0004 0.0004
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0082 0.0089
Entamoeba histolytica hypothetical protein 0.0073 0.0422 0.3841
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0012 0.00000000015615
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0148 0.0148
Brugia malayi intermediate filament protein 0.0032 0.0145 0.0145
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0051 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0082
Echinococcus granulosus geminin 0.0344 0.2236 0.2236
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Schistosoma mansoni zinc finger protein 0.001 0.0004 0.0004
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0082 0.0082
Brugia malayi hypothetical protein 0.0033 0.0155 0.0155
Schistosoma mansoni importin beta-1 0.0029 0.0127 0.0127
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0004 0.0004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0012 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0082 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0084 0.0408
Brugia malayi nuclear hormone receptor 0.001 0.0004 0.0004
Echinococcus granulosus adenosine kinase 0.1503 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0127 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0333 0.1827
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0333 0.0333
Leishmania major ribokinase, putative 0.0171 0.1081 0.1063
Brugia malayi ecdysteroid receptor 0.0022 0.0082 0.0082
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0022 0.0084 0.0084
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0084 0.0084
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0148 0.0129
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0141
Echinococcus granulosus lamin 0.0032 0.0145 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0202 0.1083
Brugia malayi hypothetical protein 0.0022 0.0084 0.0084
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0084 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0124 0.0636
Leishmania major hypothetical protein, conserved 0.0051 0.0276 0.0257
Brugia malayi PXA domain containing protein 0.0022 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0082
Trypanosoma cruzi adenosine kinase, putative 0.1503 1 1
Schistosoma mansoni nuclear receptor 0.001 0.0004 0.0004
Schistosoma mansoni ran 0.0021 0.0076 0.0076
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.002 0.0043
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0084 0.0084
Trypanosoma cruzi adenosine kinase, putative 0.0171 0.1081 0.1063
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0075 0.2175
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0095 0.0095
Echinococcus granulosus importin subunit beta 1 0.0029 0.0127 0.0127
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0082 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0087 0.0087
Echinococcus multilocularis chromobox protein 2 0.0012 0.0012 0.0012
Mycobacterium tuberculosis Adenosine kinase 0.0171 0.1081 1
Echinococcus multilocularis adenosine kinase 0.1503 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0082 0.0082
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.015 0.0939 0.0939
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0084 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0082 0.0082
Brugia malayi tailless protein 0.001 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0082 0.0082
Schistosoma mansoni smad 0.0017 0.0044 0.0044
Brugia malayi MAP kinase sur-1 0.006 0.0333 0.0333
Mycobacterium ulcerans glutaminase 0.0274 0.1768 1
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0019 0.0061 0.0042
Brugia malayi nuclear receptor NHR-88 0.001 0.0004 0.0004
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0004 0.0004
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.1999 0.1999
Echinococcus multilocularis Chromo domain 0.0012 0.0012 0.0012
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0084 0.0084
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0223 0.0247
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0148 0.0129
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0087 0.0087
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0082 0.0082
Echinococcus multilocularis lamin 0.0032 0.0145 0.0145
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0044 0.0044
Brugia malayi steroid hormone receptor 0.0022 0.0082 0.0082
Brugia malayi hypothetical protein 0.0012 0.0012 0.0012
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0413 0.2282
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0082 0.0082
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0127 0.0127
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0148 0.0148
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0082 0.0082
Echinococcus multilocularis chromobox protein 1 0.0072 0.0413 0.0413
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0012 0.00000000025662
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0056 0.0311 0.0311
Brugia malayi nuclear hormone receptor 0.0022 0.0082 0.0082
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0087 0.0087
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0012 0.0346
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0409 0.0409
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0012 0.0012
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0084 0.0084
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0127 0.0108
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0082 0.0082
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.1556 0.1556
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0012 0.00000000015615
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0082 0.0082
Trypanosoma brucei adenosine kinase, putative 0.1503 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0084 0.0408
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0148 0.0129
Leishmania major adenosine kinase, putative 0.1503 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0202 0.0202
Brugia malayi Smad1 0.0017 0.0044 0.0044
Loa Loa (eye worm) RecQ helicase 0.0024 0.0095 0.0095
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0004 0.0004
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0087 0.0087
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0333 0.0333
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0012 0.0012
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0076 0.22
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0333 0.0333
Schistosoma mansoni hypothetical protein 0.0023 0.0087 0.0087
Onchocerca volvulus 0.0022 0.0082 0.0089
Echinococcus multilocularis geminin 0.0344 0.2236 0.2236
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0333 0.0314
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0004 0.0004
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0061 0.0345 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0012 0.00000000015615
Onchocerca volvulus 0.0012 0.0012 0.0009
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0084 0.0084
Loa Loa (eye worm) glutaminase 0.0274 0.1768 0.1768
Schistosoma mansoni lamin 0.0032 0.0145 0.0145
Echinococcus granulosus programmed cell death protein 4 0.0061 0.0345 0.0345
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0076 0.0703
Brugia malayi hypothetical protein 0.001 0.0004 0.0004
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0012 0.0012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0012 0.00000000015615
Entamoeba histolytica kinase, PfkB family 0.0171 0.1081 1
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0022 0.0084 0.0671
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0082 0.0089
Schistosoma mansoni nuclear hormone receptor 0.001 0.0004 0.0004
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0148 0.0148
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0082 0.0082
Onchocerca volvulus 0.0032 0.0145 0.0159
Trichomonas vaginalis ribokinase, putative 0.0171 0.1081 0.6085
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0087 0.0087
Entamoeba histolytica hypothetical protein 0.0073 0.0422 0.3841
Trypanosoma brucei ribokinase, putative 0.0171 0.1081 0.1063
Brugia malayi hypothetical protein 0.0171 0.1081 0.1081
Leishmania major adenosine kinase-like protein 0.0171 0.1081 0.1063
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0422 0.0422
Brugia malayi RNA, U transporter 1 0.0082 0.0484 0.0484
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0276 0.0257
Brugia malayi nuclear receptor NHR-88 0.0022 0.0082 0.0082
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0004 0.0004
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0031 0.0144 0.0144
Leishmania major hypothetical protein, conserved 0.0019 0.0061 0.0042
Schistosoma mansoni intermediate filament proteins 0.0032 0.0145 0.0145
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0345 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0333 0.0314
Brugia malayi PXA domain containing protein 0.0022 0.0084 0.0084
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0084 0.0084
Brugia malayi MH2 domain containing protein 0.0017 0.0044 0.0044
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Onchocerca volvulus 0.0012 0.0012 0.0009
Echinococcus granulosus expressed protein 0.0437 0.2858 0.2858
Brugia malayi glutaminase DH11.1 0.0274 0.1768 0.1768

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.000017 M In vitro inhibitory activity against human leukocyte elastase (HLE) ChEMBL. 10340616
IC50 (binding) = 0.000017 M In vitro inhibitory activity against human leukocyte elastase (HLE) ChEMBL. 10340616
Inhibition (binding) = 16.2 % Compound was evaluated in vitro for inhibitory activity against human leukocyte elastase (HLE), at a concentration of 1.5 microM ChEMBL. 10340616
Inhibition (binding) = 16.2 % Compound was evaluated in vitro for inhibitory activity against human leukocyte elastase (HLE), at a concentration of 1.5 microM ChEMBL. 10340616
Inhibition (binding) = 45.7 % Compound was evaluated in vitro for inhibitory activity against human leukocyte elastase (HLE), at a concentration of 15 microM ChEMBL. 10340616
Inhibition (binding) = 45.7 % Compound was evaluated in vitro for inhibitory activity against human leukocyte elastase (HLE), at a concentration of 15 microM ChEMBL. 10340616
Inhibition (binding) = 76 % Compound was evaluated in vitro for inhibitory activity against human leukocyte elastase (HLE), at a concentration of 75 microM ChEMBL. 10340616
Inhibition (binding) = 76 % Compound was evaluated in vitro for inhibitory activity against human leukocyte elastase (HLE), at a concentration of 75 microM ChEMBL. 10340616
Ki (binding) = -5.02 pKi of the compound was determined against human leukocyte elastase (HLE) ChEMBL. 10340616
Ki (binding) = 5.02 Inhibition of human leukocyte elastase ChEMBL. 2299617
Log Ki (binding) = 5.02 Inhibition of human leukocyte elastase ChEMBL. 2299617
Log Ki (binding) = 5.02 pKi of the compound was determined against human leukocyte elastase (HLE) ChEMBL. 10340616
Log kOH- (ADMET) = 1.79 M-1 s-1 Alkaline hydrolysis rate of the compound ChEMBL. 2299617
Log kon (binding) = 4 Component acylation rate constant for interaction with human leukocyte elastase ChEMBL. 2299617
Log kon (binding) = 4 M-1 s-1 Component acylation rate constant for interaction with human leukocyte elastase ChEMBL. 2299617

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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