Detailed information for compound 312732

Basic information

Technical information
  • TDR Targets ID: 312732
  • Name: 2-(3-amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4 -[2-(hydroxymethyl)imidazol-1-yl]phenyl]-5-(t rifluoromethyl)pyrazole-3-carboxamide
  • MW: 501.393 | Formula: C22H15F4N7O3
  • H donors: 3 H acceptors: 5 LogP: 2.42 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCc1nccn1c1ccc(c(c1)F)NC(=O)c1cc(nn1c1ccc2c(c1)c(N)no2)C(F)(F)F
  • InChi: 1S/C22H15F4N7O3/c23-14-8-11(32-6-5-28-19(32)10-34)1-3-15(14)29-21(35)16-9-18(22(24,25)26)30-33(16)12-2-4-17-13(7-12)20(27)31-36-17/h1-9,34H,10H2,(H2,27,31)(H,29,35)
  • InChiKey: PNIJAJQGAGODFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-[2-(hydroxymethyl)-1-imidazolyl]phenyl]-5-(trifluoromethyl)-3-pyrazolecarboxamide
  • 2-(3-azanyl-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-[2-(hydroxymethyl)imidazol-1-yl]phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide
  • 2-(3-aminoindoxazen-5-yl)-N-[2-fluoro-4-(2-methylolimidazol-1-yl)phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aurora kinase A 0.0135 0.0969 0.1175
Trichomonas vaginalis AGC family protein kinase 0.0125 0.0873 0.374
Brugia malayi intracellular kinase 0.0118 0.0795 0.0862
Loa Loa (eye worm) hypothetical protein 0.0097 0.0584 0.0633
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0058 0.0196 0.0212
Entamoeba histolytica protein kinase domain containing protein 0.0118 0.0795 0.337
Brugia malayi P38 map kinase family protein 2 0.0149 0.1111 0.1204
Entamoeba histolytica protein kinase domain containing protein 0.0088 0.0499 0.2054
Loa Loa (eye worm) AUR protein kinase 0.0135 0.0969 0.1051
Giardia lamblia Kinase, NEK 0.0125 0.0873 0.3754
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0084 0.0461 0.05
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0123 0.0847 0.0847
Plasmodium falciparum calcium-dependent protein kinase 3 0.0042 0.0038 0.0005
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0074 0.0353 0.0428
Trypanosoma cruzi polo-like protein kinase, putative 0.0264 0.2262 1
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Brugia malayi Tyrosine-protein kinase abl-1 0.0169 0.1309 0.1419
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0149 0.1111 0.4909
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0062 0.024 0.0899
Echinococcus granulosus tyrosine protein kinase Lyn 0.0166 0.1285 0.1285
Schistosoma mansoni serine/threonine kinase 0.0133 0.0948 0.1638
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.024 0.026
Brugia malayi Tyrosine-protein kinase abl-1 0.0132 0.094 0.102
Brugia malayi Protein kinase domain containing protein 0.0956 0.9222 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0275 0.1058
Trypanosoma cruzi cdc2-related kinase 1 0.0107 0.0693 0.3063
Schistosoma mansoni tyrosine kinase 0.0064 0.0259 0.0447
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0147 0.1095 0.1326
Brugia malayi p70 ribosomal S6 kinase beta 0.026 0.2229 0.2417
Echinococcus multilocularis NCK adaptor protein 0.0055 0.0166 0.0201
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0147 0.1095 0.1326
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0088 0.0499 0.0541
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0147 0.1095 0.1095
Trichomonas vaginalis CAMK family protein kinase 0.0264 0.2262 0.9895
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0124 0.0386
Brugia malayi serine/threonine-protein kinase PAK 7 0.0224 0.1867 0.2024
Brugia malayi Protein kinase domain containing protein 0.0133 0.0948 0.1028
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0066 0.0273 0.0331
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0001 0.0001
Echinococcus granulosus titin 0.0039 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0143 0.1051 0.114
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0219 0.1819 0.1819
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0084 0.0461 0.2039
Plasmodium falciparum casein kinase 1 0.0058 0.0196 0.1511
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0506 0.0874
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0037 0.0065
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0049 0.0107 0.013
Echinococcus multilocularis cyclin dependent kinase 5 0.0107 0.0693 0.084
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0042 0.0038 0.0002
Brugia malayi Protein kinase domain containing protein 0.0062 0.024 0.026
Onchocerca volvulus 0.0039 0.0005 0.001
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0071 0.033 0.1457
Giardia lamblia Kinase, CMGC GSK 0.0118 0.0795 0.3406
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0002 0.0002
Leishmania major protein kinase, putative 0.0084 0.0461 0.1905
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.1278 0.2208
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0218 0.0377
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0133 0.0948 0.1028
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0146 0.1085 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0111 0.0729 0.322
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0103 0.0644 0.0699
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0771 0.3292
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0066 0.0273 0.0472
Loa Loa (eye worm) TK protein kinase 0.0092 0.0541 0.0587
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0041 0.0028 0.0031
Brugia malayi Immunoglobulin I-set domain containing protein 0.0253 0.2161 0.2344
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0499 0.2086
Giardia lamblia Kinase, AGC PKA 0.006 0.0218 0.0813
Trichomonas vaginalis AGC family protein kinase 0.0138 0.1005 0.4325
Brugia malayi Protein kinase domain containing protein 0.0447 0.4104 0.445
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0055 0.0166 0.0287
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0078 0.0397 0.048
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0037 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0288 0.0498
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0795 0.3397
Echinococcus multilocularis RNA directed DNA polymerase 0.0041 0.0024 0.0029
Echinococcus granulosus tyrosine kinase 0.0062 0.024 0.024
Echinococcus granulosus epidermal growth factor receptor 0.0614 0.5788 0.5788
Echinococcus multilocularis nervana 2 0.0127 0.0894 0.1084
Entamoeba histolytica PH domain containing protein kinase, putative 0.0152 0.1142 0.4911
Entamoeba histolytica protein kinase, putative 0.0057 0.0185 0.0658
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0184 0.1459 0.1582
Entamoeba histolytica hypothetical protein 0.0111 0.0729 0.3073
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0192 0.1542 0.1542
Echinococcus granulosus mitogen activated protein kinase 11 0.0149 0.1111 0.1111
Echinococcus granulosus titin 0.0039 0.0002 0.0002
Toxoplasma gondii casein kinase I 0.0058 0.0196 0.0722
Echinococcus multilocularis casein kinase ii subunit alpha 0.0088 0.0499 0.0605
Entamoeba histolytica protein kinase, putative 0.0111 0.0729 0.3073
Echinococcus multilocularis dual specificity protein kinase clk2 0.0084 0.0461 0.0559
Loa Loa (eye worm) hypothetical protein 0.0148 0.1101 0.1193
Schistosoma mansoni tyrosine kinase 0.0447 0.4104 0.709
Echinococcus granulosus roundabout 2 0.0039 0.0001 0.0001
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0138 0.1004 0.1088
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0069 0.0306 0.0371
Echinococcus granulosus tyrosine protein kinase shark 0.0062 0.024 0.024
Brugia malayi cell division control protein 2 homolog 0.0107 0.0693 0.0751
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0051 0.0124 0.0549
Echinococcus granulosus serine/threonine protein kinase 0.0152 0.1142 0.1142
Echinococcus multilocularis Immunoglobulin 0.0078 0.0397 0.048
Echinococcus granulosus protein kinase c iota type 0.0253 0.2162 0.2162
Entamoeba histolytica protein kinase, putative 0.0069 0.0306 0.1195
Loa Loa (eye worm) hypothetical protein 0.0178 0.1406 0.1524
Schistosoma mansoni protein kinase 0.0074 0.0353 0.061
Echinococcus granulosus mitogen activated protein kinase 14 0.0149 0.1111 0.1111
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0449 0.4129 0.4129
Echinococcus multilocularis protein kinase shaggy 0.0118 0.0795 0.0964
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0118 0.0795 0.0795
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0055 0.0166 0.018
Trypanosoma brucei protein kinase, putative 0.0118 0.0795 0.3478
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0196 0.0338
Echinococcus multilocularis N chimaerin 0.0066 0.0273 0.0331
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.043
Echinococcus granulosus tyrosine protein kinase Fyn 0.0147 0.1095 0.1095
Brugia malayi casein kinase I 0.0058 0.0196 0.0212
Trypanosoma brucei aurora B kinase 0.0135 0.0969 0.424
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0042 0.0038 0.0002
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.006 0.0218 0.0237
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0084 0.0461 0.2039
Toxoplasma gondii AGC kinase 0.006 0.0218 0.0825
Echinococcus multilocularis cyclin dependent kinase 1 0.0107 0.0693 0.084
Toxoplasma gondii AGC kinase 0.006 0.0218 0.0825
Schistosoma mansoni tyrosine kinase 0.0236 0.1988 0.3434
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0042 0.0037 0.0164
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0058 0.0196 0.0865
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0072 0.0339 0.1483
Echinococcus granulosus contactin 0.0039 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0042 0.0038 0.0005
Brugia malayi SH2 domain containing protein 0.0062 0.024 0.026
Echinococcus granulosus NDR protein kinase 0.0133 0.0948 0.0948
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0107 0.0693 0.0751
Onchocerca volvulus 0.0066 0.0276 0.0537
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0135 0.0969 0.0969
Toxoplasma gondii AGC kinase 0.026 0.2229 1
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0306 0.1231
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0049 0.0107 0.0107
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0058 0.0196 0.0196
Trichomonas vaginalis AGC family protein kinase 0.0266 0.2286 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0224 0.1869 0.1869
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0001 0.0001
Entamoeba histolytica protein kinase, putative 0.0266 0.2286 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.1051 0.114
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0074 0.0353 0.0353
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.006 0.0218 0.0264
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0042 0.0037 0.0165
Schistosoma mansoni protein kinase 0.0211 0.1735 0.2998
Giardia lamblia Kinase, NEK 0.0125 0.0873 0.3754
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0166 0.1278 0.1548
Schistosoma mansoni cell adhesion molecule 0.0039 0.0001 0.0001
Trypanosoma brucei cdc2-related kinase 3 0.0107 0.0693 0.3031
Schistosoma mansoni growth factor receptor-bound protein 0.0055 0.0166 0.0287
Brugia malayi STE20-like kinase MST 0.025 0.2123 0.2302
Brugia malayi Casein kinase II, alpha chain 0.0088 0.0499 0.0541
Echinococcus granulosus serine:threonine protein kinase N2 0.0133 0.0948 0.0948
Giardia lamblia Aurora kinase 0.0135 0.0969 0.4189
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0146 0.1085 0.1085
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0184 0.1459 0.1459
Schistosoma mansoni protein kinase 0.0211 0.1735 0.2998
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.0421 0.0457
Echinococcus multilocularis casein kinase I alpha 0.0058 0.0196 0.0237
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0391 0.3547 0.3547
Loa Loa (eye worm) hypothetical protein 0.0276 0.2386 0.2587
Brugia malayi probable protein kinase 0.0057 0.0191 0.0207
Plasmodium falciparum calcium-dependent protein kinase 5 0.0042 0.0038 0.0005
Loa Loa (eye worm) hypothetical protein 0.0088 0.0502 0.0545
Echinococcus granulosus neuroglian 0.0039 0.0001 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.024 0.026
Trypanosoma cruzi casein kinase, putative 0.0058 0.0196 0.0865
Echinococcus multilocularis neuroglian 0.0039 0.0001 0.0001
Echinococcus granulosus tyrosine kinase 0.0123 0.0847 0.0847
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Echinococcus multilocularis tyrosine kinase 0.0062 0.024 0.029
Schistosoma mansoni protein kinase 0.0051 0.0124 0.0215
Echinococcus granulosus serine:threonine protein kinase 0.0103 0.0644 0.0644
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.025 0.2123 0.2302
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0111 0.0729 0.3106
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.033 0.1335
Loa Loa (eye worm) hypothetical protein 0.0114 0.0755 0.0819
Entamoeba histolytica protein kinase, putative 0.0058 0.0196 0.0705
Trichomonas vaginalis AGC family protein kinase 0.006 0.0218 0.0842
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0147 0.1095 0.1326
Plasmodium falciparum protein kinase, putative 0.0051 0.0124 0.0829
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0166 0.1278 0.1548
Leishmania major protein kinase A catalytic subunit isoform 1 0.006 0.0218 0.0813
Echinococcus granulosus ephrin type A receptor 4 A 0.0098 0.0597 0.0597
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.006 0.0218 0.0955
Entamoeba histolytica serine/threonine protein kinase, putative 0.0264 0.2262 0.9894
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0178 0.1401 0.1401
Brugia malayi Furin-like cysteine rich region family protein 0.0614 0.5788 0.6277
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.006 0.0218 0.0965
Trypanosoma brucei protein kinase, putative 0.0071 0.033 0.1441
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0042 0.0037 0.0165
Entamoeba histolytica protein kinase, putative 0.0092 0.0541 0.2241
Giardia lamblia Kinase, CK1 Casein kinase 0.0058 0.0196 0.0711
Schistosoma mansoni vesicular amine transporter 0.0078 0.0397 0.0685
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0087 0.0487 0.0841
Brugia malayi Pleckstrin Homology Domain 0.0041 0.0025 0.0027
Echinococcus multilocularis tyrosine protein kinase HCK 0.0092 0.0541 0.0656
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.006 0.0218 0.0264
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0002 0.0003
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0106 0.0675 0.0732
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0091 0.0526 0.0638
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.024 0.026
Schistosoma mansoni protein kinase 0.0178 0.1401 0.242
Entamoeba histolytica protein kinase domain containing protein 0.0111 0.0729 0.3073
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0042 0.0038 0.0002
Echinococcus multilocularis PAK box P21 Rho binding 0.0051 0.0128 0.0156
Brugia malayi protein unc-22 0.0039 0.0002 0.0002
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0041 0.0028 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0037 0.0065
Plasmodium falciparum glycogen synthase kinase 3 0.0118 0.0795 0.7235
Onchocerca volvulus 0.0301 0.264 0.5137
Brugia malayi Variant SH3 domain containing protein 0.0066 0.0273 0.0296
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0058 0.0196 0.0237
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0097 0.0586 0.0586
Echinococcus granulosus cyclin dependent kinase 1 0.0107 0.0693 0.0693
Trichomonas vaginalis CAMK family protein kinase 0.0264 0.2262 0.9895
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0125 0.0873 0.7974
Echinococcus granulosus mitogen activated protein kinase 0.0071 0.033 0.033
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0143 0.1048 0.1048
Echinococcus granulosus Glutaredoxin protein 5 0.0127 0.0894 0.0894
Echinococcus granulosus fibroblast growth factor receptor 4 0.0236 0.1988 0.1988
Brugia malayi hypothetical protein 0.0062 0.024 0.026
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0149 0.1111 0.4909
Echinococcus multilocularis growth factor receptor bound protein 2 0.0055 0.0166 0.0201
Schistosoma mansoni growth factor receptor-bound protein 0.0055 0.0166 0.0287
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0071 0.033 0.1333
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0084 0.0461 0.2017
Brugia malayi MAP kinase sur-1 0.0071 0.033 0.0357
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0069 0.0306 0.0306
Giardia lamblia Kinase, CMGC CK2 0.0088 0.0499 0.2076
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.006 0.0218 0.0825
Loa Loa (eye worm) hypothetical protein 0.0062 0.024 0.026
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0118 0.0795 0.1374
Schistosoma mansoni hypothetical protein 0.0063 0.0246 0.0426
Loa Loa (eye worm) hypothetical protein 0.0041 0.0024 0.0026
Echinococcus multilocularis serine:threonine protein kinase 0.0103 0.0644 0.0781
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0001 0.0001
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0107 0.0693 0.0751
Schistosoma mansoni tyrosine kinase 0.0246 0.2083 0.3598
Schistosoma mansoni tyrosine kinase 0.02 0.1622 0.2802
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0499 0.2086
Trichomonas vaginalis CK1 family protein kinase 0.0058 0.0196 0.0742
Brugia malayi Protein kinase domain containing protein 0.0107 0.0693 0.0751
Echinococcus granulosus aurora kinase A 0.0135 0.0969 0.0969
Leishmania major protein kinase A catalytic subunit 0.006 0.0218 0.0813
Brugia malayi Protein kinase domain containing protein 0.0062 0.024 0.026
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.033 0.1335
Echinococcus granulosus tyrosine protein kinase Blk 0.0123 0.0847 0.0847
Echinococcus granulosus N chimaerin 0.0066 0.0273 0.0273
Echinococcus granulosus protein kinase shaggy 0.0118 0.0795 0.0795
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0042 0.0038 0.0041
Trypanosoma brucei SNF1-related protein kinases, putative 0.0042 0.0037 0.0164
Echinococcus multilocularis epidermal growth factor receptor 0.04 0.3631 0.44
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0058 0.0196 0.0238
Brugia malayi Kinase associated domain 1 family protein 0.0063 0.0246 0.0267
Schistosoma mansoni tyrosine kinase 0.0147 0.1095 0.1891
Echinococcus multilocularis calcium activated potassium channel 0.0082 0.0437 0.0529
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0147 0.1095 0.1095
Brugia malayi protein-tyrosine kinase 0.0123 0.0847 0.0919
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0051 0.0124 0.0549
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0088 0.0499 0.4409
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0192 0.1542 0.1868
Loa Loa (eye worm) AUR protein kinase 0.0135 0.0969 0.1051
Loa Loa (eye worm) hypothetical protein 0.0065 0.0271 0.0293
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.1542 0.2664
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.1014 0.1751
Entamoeba histolytica protein kinase, putative 0.026 0.2229 0.9747
Brugia malayi Protein kinase domain containing protein 0.0177 0.1391 0.1508
Brugia malayi Variant SH3 domain containing protein 0.0055 0.0166 0.018
Leishmania major protein kinase A catalytic subunit isoform 2 0.006 0.0218 0.0813
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0771 0.3292
Plasmodium vivax glycogen synthase kinase 3, putative 0.0118 0.0795 0.7235
Echinococcus multilocularis protein kinase c iota type 0.0253 0.2162 0.2619
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0039 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0499 0.2086
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.1036 0.179
Entamoeba histolytica protein kinase 2, putative 0.0146 0.1085 0.4658
Onchocerca volvulus 0.032 0.2831 0.5507
Schistosoma mansoni tyrosine kinase 0.0368 0.3311 0.5719
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0041 0.0028 0.0031
Trypanosoma cruzi polo-like protein kinase, putative 0.0264 0.2262 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0211 0.1735 0.2103
Brugia malayi Protein kinase domain 0.0074 0.0353 0.0383
Trichomonas vaginalis CK1 family protein kinase 0.0058 0.0196 0.0742
Schistosoma mansoni tyrosine kinase 0.0147 0.1095 0.1891
Echinococcus multilocularis mitogen activated protein kinase 0.0071 0.033 0.0399
Echinococcus granulosus serine:threonine protein kinase 3 0.025 0.2123 0.2123
Loa Loa (eye worm) hypothetical protein 0.0119 0.0813 0.0882
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0948 0.1638
Trichomonas vaginalis CAMK family protein kinase 0.0264 0.2262 0.9895
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0071 0.033 0.0357
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0037 0.0065
Plasmodium falciparum calcium-dependent protein kinase 2 0.0042 0.0038 0.0005
Schistosoma mansoni tyrosine kinase 0.0614 0.5788 1
Brugia malayi Sex muscle abnormal protein 5 0.0055 0.0166 0.018
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.006 0.0218 0.1727
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0066 0.0273 0.0273
Echinococcus granulosus casein kinase ii subunit alpha 0.0088 0.0499 0.0499
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0143 0.1048 0.1269
Brugia malayi serine/threonine-protein kinase 6 0.0135 0.0969 0.1051
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0001 0.0001
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0118 0.0795 0.3406
Echinococcus granulosus calcium activated potassium channel 0.0082 0.0437 0.0437
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0133 0.0948 0.1149
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0146 0.1085 1
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0074 0.0353 0.0428
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0042 0.0038 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0264 0.2262 0.3909
Brugia malayi ephrin receptor 1 precursor 0.0063 0.0246 0.0267
Brugia malayi Cam kinase protein 1 0.0042 0.0038 0.0041
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0103 0.0649 0.0704
Trichomonas vaginalis AGC family protein kinase 0.0135 0.0969 0.4168
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0058 0.0196 0.0196
Echinococcus multilocularis casein kinase i 0.0058 0.0196 0.0237
Entamoeba histolytica protein kinase, putative 0.0042 0.0038 0.0002
Entamoeba histolytica protein kinase, putative 0.0058 0.0196 0.0705
Giardia lamblia Kinase, AGC AKT 0.0106 0.0675 0.2866
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0071 0.033 0.1457
Echinococcus granulosus tyrosine protein kinase Fyn 0.0147 0.1095 0.1095
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0146 0.1085 0.4795
Loa Loa (eye worm) AGC/PKN protein kinase 0.0133 0.0948 0.1028
Loa Loa (eye worm) hypothetical protein 0.0055 0.0163 0.0176
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0051 0.0124 0.0543
Schistosoma mansoni tyrosine kinase 0.0368 0.3311 0.5719
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0391 0.3547 0.3846
Echinococcus multilocularis rac serine:threonine kinase 0.0152 0.1142 0.1384
Brugia malayi Protein kinase domain containing protein 0.0062 0.024 0.026
Plasmodium vivax serine/threonine kinase-1, putative 0.0084 0.0461 0.4046
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0693 0.1197
Echinococcus granulosus defective proboscis extension response 0.0078 0.0397 0.0397
Echinococcus multilocularis tyrosine protein kinase Abl 0.0169 0.1309 0.1586
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.1278 0.2208
Loa Loa (eye worm) hypothetical protein 0.0084 0.0459 0.0497
Brugia malayi RhoGAP domain containing protein 0.0066 0.0273 0.0296
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0078 0.0397 0.0685
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0066 0.0273 0.0296
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.04 0.3631 0.3631
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.006 0.0218 0.0264
Trichomonas vaginalis STE family protein kinase 0.0051 0.0128 0.0444
Echinococcus multilocularis Immunoglobulin 0.0078 0.0397 0.048
Trichomonas vaginalis CAMK family protein kinase 0.0264 0.2262 0.9895
Onchocerca volvulus 0.0062 0.024 0.0466
Trypanosoma brucei rac serine-threonine kinase, putative 0.0266 0.2286 1
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.1316 0.2273
Brugia malayi Protein kinase domain containing protein 0.0192 0.1542 0.1672
Brugia malayi Protein kinase domain containing protein 0.0266 0.2286 0.2479
Leishmania major protein kinase, putative 0.0072 0.0339 0.1356
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0948 0.1638
Loa Loa (eye worm) hypothetical protein 0.0092 0.0538 0.0583
Trichomonas vaginalis CK1 family protein kinase 0.0058 0.0196 0.0742
Echinococcus granulosus NCK adaptor protein 0.0055 0.0166 0.0166
Echinococcus granulosus serine:threonine protein kinase 0.0103 0.0644 0.0644
Onchocerca volvulus 0.0062 0.024 0.0466
Echinococcus granulosus casein kinase I delta 0.0058 0.0196 0.0196
Schistosoma mansoni tyrosine kinase 0.0087 0.0487 0.0841
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.1459 0.2521
Echinococcus granulosus myotubularin protein 13 0.0041 0.0025 0.0025
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0184 0.1459 0.1582
Echinococcus multilocularis myosin iiia 0.0072 0.0339 0.0411
Loa Loa (eye worm) hypothetical protein 0.0063 0.0246 0.0267
Entamoeba histolytica protein kinase, putative 0.0266 0.2286 1
Entamoeba histolytica protein kinase, putative 0.0111 0.0729 0.3073
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.1048 0.181
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0147 0.1095 0.1326
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0133 0.0948 0.1149
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0069 0.0306 0.0332
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.006 0.0218 0.0955
Giardia lamblia Kinase, STE STE20 0.0074 0.0353 0.1419
Echinococcus granulosus insulin receptor 0.0447 0.4104 0.4104
Echinococcus granulosus RNA directed DNA polymerase 0.0041 0.0024 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0729 0.1259
Brugia malayi protein kinase C II. 0.0169 0.1316 0.1427
Loa Loa (eye worm) TK protein kinase 0.0253 0.2161 0.2344
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0257 0.22 0.2386
Brugia malayi C1-like domain containing protein 0.0138 0.1004 0.1088
Entamoeba histolytica casein kinase, putative 0.0058 0.0196 0.0704
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0041 0.0024 0.0029
Echinococcus multilocularis serine threonine protein kinase 0.0175 0.1372 0.1662
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0146 0.1085 0.1315
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0306 0.1231
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0058 0.0196 0.0212
Loa Loa (eye worm) AGC/NDR protein kinase 0.0133 0.0948 0.1028
Echinococcus granulosus protein kinase C gamma type 0.0175 0.1372 0.1372
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0184 0.1459 0.2839
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0149 0.1111 0.4858
Echinococcus multilocularis dual specificity 0.0111 0.0729 0.0883
Brugia malayi Protein kinase domain containing protein 0.0069 0.0306 0.0332
Schistosoma mansoni serine/threonine-protein kinase 0.0152 0.1142 0.1973
Schistosoma mansoni atypical protein kinase C 0.026 0.2225 0.3843
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0042 0.0038 0.0046
Loa Loa (eye worm) TK/ABL protein kinase 0.0276 0.2389 0.259
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Echinococcus granulosus c-Jun N-terminal kinases 0.0257 0.22 0.22
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0147 0.1095 0.1326
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0948 0.4073
Brugia malayi Temporarily assigned gene name protein 59 0.0133 0.095 0.103
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.024 0.026
Toxoplasma gondii CMGC kinase, CK2 family 0.0088 0.0499 0.2107
Echinococcus multilocularis casein kinase I delta 0.0058 0.0196 0.0237
Schistosoma mansoni protein kinase 0.0135 0.0969 0.1675
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Loa Loa (eye worm) AGC/AKT protein kinase 0.0266 0.2286 0.2479
Trypanosoma cruzi p21-activated kinase 3, putative 0.0041 0.0028 0.0124
Echinococcus multilocularis 0.0065 0.0271 0.0328
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0133 0.0948 0.0948
Entamoeba histolytica protein kinase , putative 0.0135 0.0969 0.4144
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0042 0.0038 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0266 0.2286 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0084 0.0461 0.2039
Loa Loa (eye worm) AGC/PKA protein kinase 0.006 0.0218 0.0237
Loa Loa (eye worm) hypothetical protein 0.0042 0.0038 0.0041
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0693 0.2944
Echinococcus granulosus tyrosine protein kinase HCK 0.0092 0.0541 0.0541
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0051 0.0124 0.0396
Brugia malayi Protein kinase domain containing protein 0.0062 0.024 0.026
Echinococcus multilocularis death associated protein kinase 1 0.0859 0.8253 1
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0028 0.0049
Entamoeba histolytica protein kinase, putative 0.0051 0.0128 0.0405
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0111 0.0729 0.322
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0074 0.0353 0.0428
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0042 0.0038 0.0041
Loa Loa (eye worm) hypothetical protein 0.0084 0.0459 0.0497
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0042 0.0038 0.0046
Trichomonas vaginalis STE family protein kinase 0.0074 0.0353 0.1439
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0948 0.1638
Brugia malayi serine/threonine-protein kinase plk-2 0.0264 0.2262 0.2453
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0149 0.1111 0.4824
Echinococcus multilocularis roundabout 2 0.0039 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.032 0.2831 0.4891
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0178 0.1401 0.1698
Schistosoma mansoni hypothetical protein 0.0063 0.0246 0.0426
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0264 0.2262 0.2262
Onchocerca volvulus 0.0501 0.4646 0.9039
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0236 0.1988 0.1988
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0082 0.0437 0.0474
Echinococcus multilocularis neuroglian 0.0095 0.057 0.069
Schistosoma mansoni protein kinase 0.0058 0.0196 0.0338
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.024 0.026
Entamoeba histolytica protein kinase, putative 0.0118 0.0795 0.337
Trypanosoma cruzi cdc2-related kinase 1 0.0107 0.0693 0.3063
Brugia malayi Hr1 repeat family protein 0.0133 0.0948 0.1028
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0038 0.0065
Trichomonas vaginalis AGC family protein kinase 0.0266 0.2286 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0042 0.0038 0.0046
Trypanosoma cruzi casein kinase, putative 0.0058 0.0196 0.0865
Brugia malayi Protein kinase domain containing protein 0.0084 0.0461 0.05
Echinococcus granulosus casein kinase I alpha 0.0058 0.0196 0.0196
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0499 0.2086
Echinococcus multilocularis 0.0179 0.1412 0.1711
Schistosoma mansoni adapter molecule crk 0.0055 0.0166 0.0287
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0078 0.0397 0.0685
Loa Loa (eye worm) hypothetical protein 0.0103 0.0644 0.0699
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.006 0.0218 0.0218
Onchocerca volvulus 0.0046 0.0072 0.014
Echinococcus multilocularis tyrosine protein kinase Srms 0.0123 0.0847 0.1027
Echinococcus multilocularis roundabout 2 0.0117 0.0784 0.0951
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0107 0.0693 0.2946
Schistosoma mansoni vav2 0.0071 0.033 0.0571
Echinococcus multilocularis serine:threonine protein kinase 0.0103 0.0644 0.0781
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0127 0.0894 0.1084
Echinococcus multilocularis mitogen activated protein kinase 14 0.0149 0.1111 0.1346
Loa Loa (eye worm) TK/EGFR protein kinase 0.0614 0.5788 0.6277
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0084 0.0461 0.2017
Schistosoma mansoni protein kinase 0.0042 0.0038 0.0065
Echinococcus granulosus serine threonine protein kinase nrc 0.0146 0.1085 0.1085
Brugia malayi Protein kinase domain containing protein 0.0062 0.024 0.026
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0111 0.0729 0.079
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0138 0.1004 0.1088
Onchocerca volvulus 0.0062 0.024 0.0466
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0644 0.2729
Giardia lamblia Kinase, NEK 0.0125 0.0873 0.3754
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0499 0.2086
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0069 0.0306 0.0332
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0042 0.0038 0.0038
Brugia malayi Variant SH3 domain containing protein 0.0055 0.0166 0.018
Brugia malayi hypothetical protein 0.008 0.0421 0.0457
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.024 0.026
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0142 0.1036 0.1256
Giardia lamblia Kinase, CMGC GSK 0.0118 0.0795 0.3406
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0001 0.0001
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.006 0.0218 0.1727
Schistosoma mansoni protein kinase 0.0074 0.0353 0.061
Schistosoma mansoni serine/threonine protein kinase 0.0391 0.3547 0.6127
Loa Loa (eye worm) hypothetical protein 0.0092 0.0538 0.0583
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.006 0.0218 0.0965
Entamoeba histolytica protein kinase, putative 0.0133 0.0948 0.4049
Echinococcus multilocularis serine:threonine protein kinase 38 0.0133 0.0948 0.1149
Schistosoma mansoni tyrosine kinase 0.0068 0.0297 0.0512
Brugia malayi SRC-1 0.0147 0.1095 0.1187
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0058 0.0191 0.0207
Echinococcus multilocularis titin 0.0039 0.0002 0.0002
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0074 0.0353 0.0353
Echinococcus multilocularis c src tyrosine kinase 0.0087 0.0487 0.059
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0107 0.0693 0.0751
Onchocerca volvulus 0.0119 0.0813 0.1582
Loa Loa (eye worm) hypothetical protein 0.0042 0.0037 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0163 0.0595
Brugia malayi protein kinase C3,putative 0.014 0.1017 0.1103
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0107 0.0693 0.2946
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0111 0.0732 0.3122
Loa Loa (eye worm) hypothetical protein 0.0039 0.0001 0.0001
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0449 0.4129 0.5003
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.043
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0461 0.0797
Echinococcus granulosus c src tyrosine kinase 0.0087 0.0487 0.0487
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0084 0.0461 0.1934
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0134 0.0963 0.1166
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0042 0.0038 0.0005
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0042 0.0038 0.0038
Echinococcus granulosus dual specificity protein kinase clk2 0.0084 0.0461 0.0461
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0236 0.1988 0.2409
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0114 0.0757 0.3229
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0061 0.0227 0.0247
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0072 0.0339 0.1499
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0264 0.2262 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0421 0.0457
Brugia malayi Protein kinase domain containing protein 0.0103 0.0644 0.0699
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0118 0.0795 0.3515
Trichomonas vaginalis AGC family protein kinase 0.0135 0.0969 0.4168
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0306 0.1231
Echinococcus granulosus serine:threonine kinase SAD 1 0.0042 0.0037 0.0037
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0118 0.0795 0.3457
Trichomonas vaginalis AGC family protein kinase 0.0266 0.2286 1
Echinococcus multilocularis casein kinase I delta 0.0058 0.0196 0.0237
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.033 0.1335
Echinococcus granulosus rho-associated protein kinase 1 0.032 0.2831 0.2831
Echinococcus granulosus casein kinase I alpha 0.0058 0.0196 0.0196
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0178 0.1401 0.1519
Trichomonas vaginalis AGC family protein kinase 0.0266 0.2286 1
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Leishmania major protein kinase, putative 0.0084 0.0461 0.1905
Echinococcus granulosus casein kinase I delta 0.0058 0.0196 0.0196
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0041 0.0028 0.0124
Leishmania major protein kinase, putative 0.0042 0.0038 0.0002
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0042 0.0038 0.0041
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0257 0.22 0.2666
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0039 0.0002 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0266 0.2286 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.026 0.2229 0.2417
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0066 0.0273 0.0472
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0629 0.594 0.6441
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0275 0.1058
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0693 0.2944
Onchocerca volvulus 0.0125 0.087 0.1693
Echinococcus granulosus cyclin dependent kinase 5 0.0107 0.0693 0.0693
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Echinococcus granulosus nervana 2 0.0127 0.0894 0.0894
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0039 0.0001 0.0001
Loa Loa (eye worm) SRC-1 0.0147 0.1095 0.1187
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0264 0.2262 0.2453
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.006 0.0218 0.0965
Loa Loa (eye worm) hypothetical protein 0.0078 0.0399 0.0432
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0072 0.0339 0.1499
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0107 0.0693 0.0693
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0118 0.0795 0.0964
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0142 0.1036 0.1036
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0184 0.1459 0.1768
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0039 0.0001 0.0001
Trypanosoma cruzi Protein kinase B 0.0152 0.1142 0.5047
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0058 0.0196 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0461 0.0797
Entamoeba histolytica protein kinase, putative 0.0135 0.0969 0.4144
Echinococcus granulosus casein kinase i 0.0058 0.0196 0.0196
Toxoplasma gondii aurora kinase 0.0135 0.0969 0.4252
Echinococcus multilocularis serine:threonine protein kinase N2 0.0133 0.0948 0.1149
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0042 0.0038 0.0038
Giardia lamblia Kinase, PLK 0.0264 0.2262 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0071 0.033 0.0399
Schistosoma mansoni nephrin 0.0098 0.0595 0.1028
Brugia malayi serine/threonine kinase 12 0.0135 0.0969 0.1051
Schistosoma mansoni serine/threonine protein kinase 0.021 0.1726 0.2983
Brugia malayi serine/threonine protein kinase 6 0.0135 0.0969 0.1051
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0071 0.033 0.1441
Loa Loa (eye worm) TK/ROR protein kinase 0.007 0.0321 0.0348
Echinococcus multilocularis mitogen activated protein kinase 11 0.0149 0.1111 0.1346
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0135 0.0969 0.4144
Schistosoma mansoni kinase 0.0283 0.2454 0.4239
Echinococcus multilocularis activin receptor type 0.0051 0.0124 0.0151
Brugia malayi Protein kinase domain containing protein 0.018 0.1421 0.1541
Entamoeba histolytica protein kinase, putative 0.0074 0.0353 0.1404
Entamoeba histolytica cell division protein kinase 2, putative 0.0107 0.0693 0.2915
Loa Loa (eye worm) hypothetical protein 0.0114 0.0759 0.0824
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0236 0.1988 0.2409
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0316 0.2787 0.3022
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0693 0.2944
Plasmodium falciparum calcium-dependent protein kinase 1 0.0042 0.0038 0.0005
Echinococcus granulosus tyrosine protein kinase Src42A 0.0091 0.0526 0.0526
Entamoeba histolytica casein kinase 1, putative 0.0058 0.0196 0.0704
Entamoeba histolytica protein kinase, putative 0.0135 0.0969 0.4144
Onchocerca volvulus 0.0084 0.0459 0.0892
Echinococcus granulosus tyrosine protein kinase Src42A 0.0147 0.1095 0.1095
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.1048 0.181
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0123 0.0847 0.1027
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0135 0.0969 0.8898
Loa Loa (eye worm) TK/INSR protein kinase 0.0447 0.4104 0.445
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Loa Loa (eye worm) TK/EPH protein kinase 0.0116 0.0779 0.0845
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0219 0.1819 0.2205
Echinococcus granulosus casein kinase I alpha 0.0058 0.0196 0.0196
Schistosoma mansoni serine/threonine protein kinase 0.0257 0.22 0.3801
Brugia malayi map kinase activated protein kinase protein 2 0.0391 0.3547 0.3846
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0224 0.1869 0.2265
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0276 0.2389 0.2895
Trypanosoma brucei polo-like protein kinase 0.0264 0.2262 0.9896
Trypanosoma cruzi casein kinase, putative 0.0058 0.0196 0.0865
Echinococcus granulosus growth factor receptor bound protein 2 0.0055 0.0166 0.0166
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0166 0.1278 0.1278
Schistosoma mansoni tyrosine kinase 0.04 0.3631 0.6273
Trypanosoma cruzi cdc2-related kinase 3 0.0107 0.0693 0.3063
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0146 0.108 0.1171
Schistosoma mansoni protein kinase 0.0042 0.0038 0.0065
Loa Loa (eye worm) AUR protein kinase 0.0135 0.0969 0.1051
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0057 0.0191 0.0191
Echinococcus granulosus dual specificity 0.0111 0.0729 0.0729
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0169 0.1316 0.1427
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0062 0.024 0.024
Echinococcus multilocularis insulin receptor 0.0447 0.4104 0.4973
Echinococcus granulosus Immunoglobulin 0.0078 0.0397 0.0397
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0072 0.0339 0.1342
Schistosoma mansoni serine/threonine kinase 0.0082 0.0437 0.0755
Echinococcus multilocularis ephrin type A receptor 4 A 0.0098 0.0597 0.0723
Brugia malayi Protein kinase domain containing protein 0.0178 0.1401 0.1519
Onchocerca volvulus 0.0058 0.0196 0.0381
Echinococcus multilocularis mitogen activated protein kinase 14 0.0149 0.1111 0.1346
Onchocerca volvulus 0.0118 0.0795 0.1547
Echinococcus multilocularis Protein kinase C, brain isozyme 0.021 0.1726 0.2092
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0055 0.0166 0.018
Schistosoma mansoni nephrin 0.0039 0.0001 0.0001
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0049 0.0109 0.032
Entamoeba histolytica PH domain containing protein kinase, putative 0.0152 0.1142 0.4911
Trichomonas vaginalis STE family protein kinase 0.0074 0.0353 0.1439
Echinococcus multilocularis nervana 2 0.0127 0.0894 0.1084
Echinococcus granulosus nervana 2 0.0127 0.0894 0.0894
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0264 0.2262 0.2742
Schistosoma mansoni nck2/grb4 0.0055 0.0166 0.0287
Plasmodium falciparum protein kinase 5 0.0107 0.0693 0.6259
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0118 0.0795 0.0862
Plasmodium vivax casein kinase 1, putative 0.0058 0.0196 0.1511
Plasmodium falciparum NIMA related kinase 1 0.0125 0.0873 0.7974
Giardia lamblia Kinase, CMGC CDK 0.0107 0.0693 0.2946
Giardia lamblia Kinase, CMGC CLK 0.0084 0.0461 0.1905
Schistosoma mansoni protein kinase C mu 0.0138 0.1004 0.1734
Echinococcus multilocularis serine:threonine protein kinase N2 0.0133 0.0948 0.1149
Plasmodium falciparum calcium-dependent protein kinase 4 0.0042 0.0038 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.021 0.1726 0.2983
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.024 0.026
Trichomonas vaginalis AGC family protein kinase 0.0135 0.0969 0.4168
Loa Loa (eye worm) hypothetical protein 0.0076 0.0378 0.041
Trichomonas vaginalis CAMK family protein kinase 0.0264 0.2262 0.9895
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0224 0.1867 0.2024
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.024 0.026
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0969 0.1675
Plasmodium falciparum protein serine/threonine kinase-1 0.0084 0.0461 0.4046
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0062 0.024 0.029
Echinococcus granulosus roundabout 2 0.0117 0.0784 0.0784
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0001 0.0001
Entamoeba histolytica protein kinase domain containing protein 0.0135 0.0969 0.4144
Schistosoma mansoni tyrosine kinase 0.0062 0.024 0.0414
Echinococcus multilocularis Glutaredoxin protein 5 0.0127 0.0894 0.1084
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0437 0.0755
Brugia malayi Protein kinase domain containing protein 0.0133 0.0948 0.1028
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0218 0.0377
Loa Loa (eye worm) AGC/PKA protein kinase 0.006 0.0218 0.0237
Trichomonas vaginalis CAMK family protein kinase 0.0264 0.2262 0.9895
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0042 0.0038 0.0166
Brugia malayi Protein kinase c protein 2 0.0096 0.0582 0.0631
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0041 0.0028 0.0034
Echinococcus multilocularis cyclin dependent kinase 0.0107 0.0693 0.084
Trypanosoma cruzi aurora B kinase, putative 0.0135 0.0969 0.4285
Schistosoma mansoni neuroglian 0.0039 0.0001 0.0001
Schistosoma mansoni protein kinase 0.0042 0.0038 0.0065
Echinococcus granulosus raf serine:threonine protein kinase 0.0067 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0055 0.0166 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0038 0.0043
Onchocerca volvulus 0.0062 0.024 0.0466
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0437 0.0755
Brugia malayi Protein kinase domain containing protein 0.0053 0.0148 0.016
Schistosoma mansoni serine/threonine-protein kinase 0.0152 0.1142 0.1973
Brugia malayi Stress-activated protein kinase jnk-1 0.0257 0.22 0.2386
Onchocerca volvulus Serine\/threonine kinase homolog 0.0264 0.2262 0.4402
Loa Loa (eye worm) hypothetical protein 0.0066 0.0276 0.03
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0795 0.3397
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0142 0.1036 0.1124
Schistosoma mansoni protein kinase 0.0057 0.0191 0.0329
Echinococcus granulosus tyrosine protein kinase ABL1 0.0276 0.2389 0.2389
Loa Loa (eye worm) TK protein kinase 0.0123 0.0847 0.0919
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0147 0.1095 0.1326
Plasmodium vivax calcium-dependent protein kinase, putative 0.0042 0.0038 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0266 0.2286 1
Leishmania major casein kinase II, putative 0.0088 0.0499 0.2076
Trypanosoma cruzi cdc2-related kinase 3 0.0107 0.0693 0.3063
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0499 0.2086
Onchocerca volvulus 0.0039 0.0002 0.0003
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0219 0.1819 0.1973
Echinococcus multilocularis hypothetical protein 0.0063 0.0246 0.0298
Trypanosoma brucei protein kinase, putative 0.0051 0.0124 0.0543
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0391 0.3547 0.4298
Entamoeba histolytica protein kinase, putative 0.0044 0.0051 0.0061
Loa Loa (eye worm) hypothetical protein 0.008 0.0421 0.0457
Trichomonas vaginalis STE family protein kinase 0.0074 0.0353 0.1439
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0147 0.1095 0.1326
Echinococcus granulosus roundabout 2 0.0039 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0087 0.0487 0.0841
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0071 0.033 0.1457
Trypanosoma brucei cdc2-related kinase 1 0.0107 0.0693 0.3031
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0111 0.0729 0.3187
Schistosoma mansoni titin 0.0039 0.0002 0.0003
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0042 0.0037 0.0045
Brugia malayi casein kinase 1, delta 0.0058 0.0196 0.0212
Entamoeba histolytica cell division protein kinase 2, putative 0.0107 0.0693 0.2915
Onchocerca volvulus 0.0062 0.024 0.0466
Echinococcus multilocularis serine:threonine protein kinase 3 0.025 0.2123 0.2573
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0149 0.1111 0.1204
Leishmania major protein kinase, putative 0.0051 0.0124 0.039
Echinococcus multilocularis casein kinase I alpha 0.0058 0.0196 0.0237
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0084 0.0461 0.2039
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0147 0.1095 0.1326
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.006 0.0218 0.0965
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0107 0.0693 0.2991
Echinococcus multilocularis roundabout 2 0.0039 0.0001 0.0001
Schistosoma mansoni protein kinase 0.0051 0.0128 0.0222
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0135 0.0969 0.4144
Brugia malayi Protein kinase domain containing protein 0.0111 0.0729 0.079
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.033 0.0569
Loa Loa (eye worm) hypothetical protein 0.0114 0.0759 0.0824
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0306 0.0529
Trichomonas vaginalis AGC family protein kinase 0.0135 0.0969 0.4168
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0211 0.1735 0.1735
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0057 0.0191 0.0231
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.006 0.0218 0.0264
Trypanosoma brucei Casein kinase II 0.0088 0.0499 0.2184
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.1819 0.3143
Onchocerca volvulus Tyrosine kinase homolog 0.055 0.514 1
Trypanosoma cruzi casein kinase, putative 0.0058 0.0196 0.0865
Plasmodium vivax protein kinase Crk2 0.0107 0.0693 0.6259
Entamoeba histolytica protein kinase, putative 0.0057 0.0185 0.0658
Schistosoma mansoni tyrosine kinase 0.0368 0.3311 0.5719
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Trichomonas vaginalis STE family protein kinase 0.0072 0.0339 0.1377
Brugia malayi phosphoinositide-dependent protein kinase I 0.0069 0.0306 0.0332
Brugia malayi Fibronectin type III domain containing protein 0.008 0.0421 0.0457
Echinococcus granulosus twitchin 0.0114 0.076 0.076
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0147 0.1095 0.1326
Loa Loa (eye worm) hypothetical protein 0.0125 0.087 0.0944
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0072 0.0339 0.1342
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0042 0.0038 0.0046
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0152 0.1142 0.5047
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.006 0.0218 0.0218
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0948 0.4073
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.033 0.1335
Schistosoma mansoni ephrin receptor 0.0098 0.0597 0.1031
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0948 0.4073
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0039 0.0005 0.0022
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0135 0.0969 0.1175
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.024 0.026
Leishmania major casein kinase, putative 0.0058 0.0196 0.0711
Plasmodium falciparum serine/threonine protein kinase, putative 0.0135 0.0969 0.8898
Giardia lamblia Kinase, STE STE20 0.0072 0.0339 0.1356
Echinococcus multilocularis tyrosine protein kinase Blk 0.0123 0.0847 0.1027
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0956 0.9222 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.1051 0.114
Plasmodium falciparum casein kinase 2, alpha subunit 0.0088 0.0499 0.4409
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0125 0.0873 0.3811
Echinococcus multilocularis cyclin dependent kinase 1 0.0107 0.0693 0.084
Trypanosoma cruzi casein kinase, putative 0.0058 0.0196 0.0865
Entamoeba histolytica protein kinase, putative 0.0049 0.0109 0.032
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.006 0.0218 0.0218
Schistosoma mansoni ste20-related kinase 0.0196 0.1588 0.2743
Echinococcus granulosus cyclin dependent kinase 0.0107 0.0693 0.0693
Schistosoma mansoni protein kinase 0.0088 0.0499 0.0863
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0071 0.033 0.1313
Schistosoma mansoni tyrosine kinase 0.0447 0.4104 0.709
Loa Loa (eye worm) TK/FER protein kinase 0.0062 0.024 0.026
Echinococcus multilocularis myotubularin protein 13 0.0041 0.0025 0.003
Entamoeba histolytica p21-activated kinase 0.0079 0.041 0.1658
Echinococcus multilocularis rho associated protein kinase 0.032 0.2831 0.343
Echinococcus multilocularis casein kinase I alpha 0.0058 0.0196 0.0237
Loa Loa (eye worm) hypothetical protein 0.006 0.0218 0.0237
Loa Loa (eye worm) hypothetical protein 0.0123 0.0845 0.0917
Loa Loa (eye worm) CAMK protein kinase 0.0039 0.0002 0.0002
Entamoeba histolytica casein kinase, putative 0.0088 0.0499 0.2054
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0074 0.0353 0.0353
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0142 0.1036 0.1124
Schistosoma mansoni cell adhesion molecule 0.0039 0.0001 0.0001
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0041 0.0028 0.0028
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0118 0.0795 0.0862
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0133 0.0948 0.0948
Echinococcus granulosus epidermal growth factor receptor 0.04 0.3631 0.3631
Echinococcus granulosus tyrosine protein kinase Fyn 0.0147 0.1095 0.1095
Echinococcus granulosus tyrosine protein kinase Src64B 0.0147 0.1095 0.1095
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0028 0.0049
Echinococcus granulosus Protein kinase C brain isozyme 0.021 0.1726 0.1726
Giardia lamblia Kinase, CMGC MAPK 0.0071 0.033 0.1313
Echinococcus multilocularis raf serine:threonine protein kinase 0.0067 0.0288 0.0349
Echinococcus granulosus hypothetical protein 0.0065 0.0271 0.0271
Brugia malayi Immunoglobulin I-set domain containing protein 0.0629 0.594 0.6441
Plasmodium vivax unspecified product 0.0088 0.0499 0.4409
Echinococcus granulosus mitogen activated protein kinase 3 0.0071 0.033 0.033
Echinococcus multilocularis mitogen activated protein kinase 11 0.0149 0.1111 0.1346
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0184 0.1459 0.1582
Brugia malayi putative serine/threonine kinase SADA gamma 0.0042 0.0037 0.0041
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0127 0.0894 0.0894
Trichomonas vaginalis CAMK family protein kinase 0.0264 0.2262 0.9895
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0071 0.033 0.1457
Loa Loa (eye worm) hypothetical protein 0.0041 0.0025 0.0027
Echinococcus multilocularis tyrosine protein kinase shark 0.0062 0.024 0.029
Trypanosoma brucei casein kinase I, isoform 2 0.0058 0.0196 0.0856
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0461 0.1918
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0037 0.0041
Giardia lamblia Kinase, CMGC CDK 0.0107 0.0693 0.2946
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.006 0.0218 0.0955
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0437 0.181
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0134 0.0963 0.0963
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0192 0.1542 0.1672
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0042 0.0037 0.0041
Schistosoma mansoni tyrosine kinase 0.04 0.3631 0.6273
Trichomonas vaginalis STE family protein kinase 0.0074 0.0353 0.1439
Loa Loa (eye worm) hypothetical protein 0.0097 0.0586 0.0636
Echinococcus multilocularis protein kinase c epsilon type 0.0169 0.1316 0.1594
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0196 0.0339
Echinococcus multilocularis epidermal growth factor receptor 0.0614 0.5788 0.7014
Trypanosoma cruzi casein kinase II, putative 0.0088 0.0499 0.2207
Brugia malayi Protein kinase domain containing protein 0.0184 0.1459 0.1582
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0039 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0437 0.0755
Leishmania major protein kinase, putative 0.0135 0.0969 0.4189
Echinococcus granulosus neuroglian 0.0095 0.057 0.057
Schistosoma mansoni cell adhesion molecule 0.0099 0.0611 0.1056
Brugia malayi SH2 domain containing protein 0.0062 0.024 0.026
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0218 0.0377
Giardia lamblia Kinase, AGC PKA 0.0146 0.1085 0.4708
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0693 0.1197
Echinococcus granulosus protein kinase c epsilon type 0.0169 0.1316 0.1316
Entamoeba histolytica protein kinase domain containing protein 0.0118 0.0795 0.337
Brugia malayi Protein kinase domain containing protein 0.0082 0.0437 0.0474
Echinococcus granulosus activin receptor type 0.0051 0.0124 0.0124
Onchocerca volvulus 0.0062 0.024 0.0466
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.0499 0.2086
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0166 0.1278 0.1278
Onchocerca volvulus 0.0143 0.1051 0.2045
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0135 0.0969 0.4144
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0071 0.033 0.1313
Trichomonas vaginalis STE family protein kinase 0.0125 0.0873 0.374
Echinococcus granulosus tyrosine protein kinase Srms 0.0062 0.024 0.024

Activities

Activity type Activity value Assay description Source Reference
aPTT (functional) 0 uM Activated partial thromboplastin time was determined in human plasma; No data ChEMBL. 15771420
Binding (ADMET) 0 % Binding affinity of compound was determined against human plasma protein; No data ChEMBL. 15771420
Ki (binding) = 1 nM Binding affinity against human Coagulation factor Xa ChEMBL. 15771420
Ki (binding) = 1 nM Binding affinity against human Coagulation factor Xa ChEMBL. 15771420
Ki (binding) = 1700 nM Binding affinity against human thrombin ChEMBL. 15771420
Ki (binding) = 1700 nM Binding affinity against human thrombin ChEMBL. 15771420
Permeability (functional) = 0.0000001 cm s-1 Apparent cell permeability of the compound was determined in Caco-2 cell line ChEMBL. 15771420
Permeability (functional) = 0.0000001 cm s-1 Apparent cell permeability of the compound was determined in Caco-2 cell line ChEMBL. 15771420

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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