Detailed information for compound 316161

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 308.8 | Formula: C17H21ClO3
  • H donors: 2 H acceptors: 2 LogP: 2.69 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1=CC[C@@]2(C[C@H]1[C@@H](OC2(C)C)c1ccc(cc1Cl)O)O
  • InChi: 1S/C17H21ClO3/c1-10-6-7-17(20)9-13(10)15(21-16(17,2)3)12-5-4-11(19)8-14(12)18/h4-6,8,13,15,19-20H,7,9H2,1-3H3/t13-,15+,17+/m1/s1
  • InChiKey: SHRHJCVYKRLOJT-KMFMINBZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens estrogen receptor 1 Starlite/ChEMBL References
Homo sapiens estrogen receptor 2 (ER beta) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein estrogen receptor 2 (ER beta) 495 aa 418 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.8656 1 1
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0092 0.0085
Brugia malayi Cadherin domain containing protein 0.0145 0.0135 0.0135
Onchocerca volvulus 0.0448 0.0486 0.7911
Schistosoma mansoni notch 0.0145 0.0135 0.0135
Echinococcus granulosus neurogenic locus protein delta 0.0145 0.0135 0.0135
Brugia malayi jmjC domain containing protein 0.0034 0.0007 0.0007
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0089 0.007 0.1134
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0001 0.0001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0011 0.0182
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0558 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0035 0.0007 0.0007
Echinococcus granulosus neural cadherin 0.0145 0.0135 0.0135
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0558 0.0614 0.0608
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0558 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0038 0.0011 0.0011
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0558 0.0614 0.0614
Echinococcus granulosus protein kinase C gamma type 0.0035 0.0007 0.0007
Onchocerca volvulus Neurogenic locus notch homolog 0.0145 0.0135 0.2192
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0007 0.0007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.8656 1 1
Trichomonas vaginalis immunophilin, putative 0.0089 0.007 0.0063
Toxoplasma gondii target of rapamycin (TOR), putative 0.6438 0.7429 1
Echinococcus granulosus chromobox protein 1 0.0068 0.0046 0.0046
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0001 0.0001
Entamoeba histolytica protein kinase, putative 0.0107 0.0092 0.0085
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0558 0.0614 0.0572
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.6892 0.7955 0.7941
Brugia malayi Animal haem peroxidase family protein 0.0448 0.0486 0.0486
Loa Loa (eye worm) phosphatidylinositol 3 0.0558 0.0614 0.0614
Echinococcus multilocularis nervana 2 0.0066 0.0044 0.0044
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1637 0.1865 0.1828
Brugia malayi EGF-like domain containing protein 0.0145 0.0135 0.0135
Onchocerca volvulus Putative cubilin 0.0145 0.0135 0.2192
Loa Loa (eye worm) Notch2 0.0145 0.0135 0.0135
Schistosoma mansoni chromobox protein 0.0068 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.5172 0.5962 0.596
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0558 0.0614 0.0614
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0035 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.4667 0.5376 0.5373
Schistosoma mansoni immunophilin 0.0089 0.007 0.007
Echinococcus granulosus protein jagged 2 0.0145 0.0135 0.0135
Brugia malayi EGF-like domain containing protein 0.0145 0.0135 0.0135
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0007 0.0001
Echinococcus granulosus fibropellin Ia 0.0145 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0001
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0558 0.0614 0.0827
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.8656 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0558 0.0614 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0558 0.0614 0.0609
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2903 0.3332 0.3285
Schistosoma mansoni fkbp-rapamycin associated protein 0.1637 0.1865 0.1865
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1637 0.1865 0.1865
Trichomonas vaginalis conserved hypothetical protein 0.1079 0.1217 0.1212
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0558 0.0614 1
Loa Loa (eye worm) AGC/NDR protein kinase 0.0035 0.0007 0.0007
Brugia malayi Calcium binding EGF domain containing protein 0.0145 0.0135 0.0135
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0035 0.0007 0.0007
Brugia malayi Calcium binding EGF domain containing protein 0.0145 0.0135 0.0135
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0067 0.0045 0.0728
Brugia malayi Peroxidasin 0.0448 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Schistosoma mansoni septate junction protein 0.0145 0.0135 0.0135
Trypanosoma brucei target of rapamycin kinase 3, putative 0.6892 0.7955 0.7941
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0076 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0007 0.0007
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3595 0.4134 0.4093
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0558 0.0614 0.0827
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0558 0.0614 0.0608
Onchocerca volvulus 0.003 0.0002 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.2903 0.3332 0.3328
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0089 0.007 0.0063
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0558 0.0614 0.0608
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0035 0.0035
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.8656 1 1
Echinococcus granulosus protein kinase c epsilon type 0.0035 0.0007 0.0007
Echinococcus multilocularis neurogenic locus notch protein 0.0145 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Plasmodium vivax hypothetical protein 0.0558 0.0614 1
Loa Loa (eye worm) hypothetical protein 0.1079 0.1217 0.1217
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0074 0.0052 0.0008
Schistosoma mansoni cell polarity protein 0.0145 0.0135 0.0135
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.8656 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0448 0.0486 0.0486
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2903 0.3332 0.3332
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0558 0.0614 0.0609
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0089 0.007 0.0025
Echinococcus granulosus notch 0.0145 0.0135 0.0135
Echinococcus granulosus neurogenic locus notch protein 0.0145 0.0135 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0007 0.0007
Echinococcus multilocularis slit 2 protein 0.0145 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0046 0.004
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0067 0.0045 0.0045
Echinococcus multilocularis 0.0558 0.0614 0.0614
Schistosoma mansoni hypothetical protein 0.0145 0.0135 0.0135
Echinococcus granulosus protein kinase c iota type 0.0035 0.0007 0.0007
Loa Loa (eye worm) FKBP5 protein 0.0089 0.007 0.007
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0089 0.007 0.007
Echinococcus multilocularis notch 0.0145 0.0135 0.0135
Onchocerca volvulus Chorion peroxidase homolog 0.0448 0.0486 0.7911
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0067 0.0045 0.0728
Onchocerca volvulus 0.0448 0.0486 0.7911
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0558 0.0614 0.0609
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0092 0.0085
Brugia malayi Hr1 repeat family protein 0.0035 0.0007 0.0007
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0558 0.0614 0.0549
Schistosoma mansoni hypothetical protein 0.0145 0.0135 0.0135
Brugia malayi hypothetical protein 0.0448 0.0486 0.0486
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0558 0.0614 0.0614
Echinococcus multilocularis fibropellin Ia 0.0145 0.0135 0.0135
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0007 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0007 0.0007
Echinococcus granulosus slit 2 protein 0.0145 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0049 0.0024 0.0024
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2903 0.3332 0.3285
Toxoplasma gondii EGF family domain-containing protein 0.0145 0.0135 0.0181
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0558 0.0614 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0015 0.0008
Leishmania major phosphatidylinositol 4-kinase, putative 0.0558 0.0614 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.1637 0.1865 0.186
Onchocerca volvulus 0.0558 0.0614 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0007 0.0007
Schistosoma mansoni immunophilin 0.0076 0.0056 0.0056
Echinococcus multilocularis protein kinase c iota type 0.0035 0.0007 0.0007
Loa Loa (eye worm) phosphatidylinositol 3 0.8656 1 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0558 0.0614 0.0614
Echinococcus multilocularis protein jagged 2 0.0145 0.0135 0.0135
Echinococcus multilocularis protein jagged 1 0.0145 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0076 0.0056 0.0056
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0792 0.0885 0.0885
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0092 0.0085
Echinococcus granulosus protein jagged 1 0.0145 0.0135 0.0135
Giardia lamblia GTOR 0.8656 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0558 0.0614 0.0609
Echinococcus granulosus serine/threonine protein kinase 0.0074 0.0052 0.0052
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0035 0.0007 0.0007
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0558 0.0614 0.0614
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2903 0.3332 0.3302
Trichomonas vaginalis PIKK family atypical protein kinase 0.739 0.8533 0.8532
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0007 0.0007
Echinococcus multilocularis rac serine:threonine kinase 0.0074 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0558 0.0614 0.0608
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0558 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0092 0.0085
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0558 0.0614 0.0549
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0001 0.0001
Brugia malayi Heterochromatin protein 1 0.0068 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0558 0.0614 0.0614
Loa Loa (eye worm) phosphatidylinositol 3 0.0558 0.0614 0.0614
Schistosoma mansoni hypothetical protein 0.0145 0.0135 0.0135
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0558 0.0614 0.0614
Schistosoma mansoni serine/threonine-protein kinase 0.0074 0.0052 0.0052
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0145 0.0135 0.0135
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1637 0.1865 0.1865
Trichomonas vaginalis PIKK family atypical protein kinase 0.6438 0.7429 0.7427
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0558 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.4674 0.5384 0.5382
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0066 0.0044 0.0044
Brugia malayi Muscle positioning protein 4 0.0145 0.0135 0.0135
Brugia malayi EGF-like domain containing protein 0.0145 0.0135 0.0135
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0558 0.0614 0.0572
Schistosoma mansoni hypothetical protein 0.1266 0.1434 0.1434
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0089 0.007 0.1134
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0558 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.6885 0.7947 0.7946
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.2659 0.2654
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0089 0.007 0.0025
Schistosoma mansoni serine/threonine-protein kinase 0.0074 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.5121 0.5903 0.59
Schistosoma mansoni laminin gamma-3 chain 0.0145 0.0135 0.0135
Onchocerca volvulus Peroxidase homolog 0.0448 0.0486 0.7911
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0007 0.0007
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0145 0.0135 0.2192
Loa Loa (eye worm) hypothetical protein 0.1764 0.2012 0.2012
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0558 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.003 0.0002 0.0002
Loa Loa (eye worm) blistered cuticle protein 3 0.0448 0.0486 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.1079 0.1217 0.1212
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0558 0.0614 0.0572
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0558 0.0614 0.0614
Echinococcus multilocularis chromobox protein 1 0.0068 0.0046 0.0046
Schistosoma mansoni notch 0.0145 0.0135 0.0135
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0089 0.007 0.0025
Toxoplasma gondii FATC domain-containing protein 0.1637 0.1865 0.251
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0011 0.0005
Echinococcus multilocularis neurogenic locus protein delta 0.0145 0.0135 0.0135
Onchocerca volvulus Slit protein homolog 0.0145 0.0135 0.2192
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0007 0.0007
Brugia malayi p70 ribosomal S6 kinase beta 0.0101 0.0084 0.0084
Trypanosoma brucei rac serine-threonine kinase, putative 0.0107 0.0092 0.0022
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0558 0.0614 0.0608
Onchocerca volvulus 0.0145 0.0135 0.2192
Schistosoma mansoni chromobox protein 0.0068 0.0046 0.0046
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0089 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0007 0.0007
Schistosoma mansoni peroxidasin 0.0448 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0558 0.0614 0.0572
Echinococcus granulosus peroxidasin 0.0448 0.0486 0.0486
Giardia lamblia Phosphatidylinositol 4-kinase 0.0558 0.0614 0.0614
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0145 0.0135 0.0135
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0089 0.007 0.5
Echinococcus multilocularis fat cadherin tumor suppressor 0.0145 0.0135 0.0135
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0092 0.0085
Brugia malayi protein kinase C II. 0.0035 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.1824 0.2081 0.2076
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2903 0.3332 0.3332
Trypanosoma cruzi Protein kinase B 0.0074 0.0052 0.0008
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.2903 0.3332 0.3328
Trichomonas vaginalis PIKK family atypical protein kinase 0.1637 0.1865 0.186
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0235 0.0229
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0075 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.8656 1 1
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0035 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.1637 0.1865 0.1859
Schistosoma mansoni peroxidasin 0.0448 0.0486 0.0486
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2903 0.3332 0.3332
Leishmania major hypothetical protein, conserved 0.0558 0.0614 0.0549
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1637 0.1865 0.1828
Schistosoma mansoni notch 0.0145 0.0135 0.0135
Plasmodium vivax hypothetical protein, conserved 0.0558 0.0614 1
Echinococcus multilocularis protein jagged 1 0.0145 0.0135 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.1266 0.1434 0.1429
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0089 0.007 0.007
Onchocerca volvulus 0.0145 0.0135 0.2192
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0089 0.007 0.0063
Onchocerca volvulus 0.0558 0.0614 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0035 0.0007 0.0007
Echinococcus granulosus serine:threonine protein kinase N2 0.0035 0.0007 0.0007
Onchocerca volvulus 0.0231 0.0235 0.3827
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0558 0.0614 0.0614
Entamoeba histolytica protein kinase 2, putative 0.0067 0.0045 0.0038
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0558 0.0614 0.0609
Loa Loa (eye worm) hypothetical protein 0.0558 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Echinococcus multilocularis Glutaredoxin protein 5 0.0066 0.0044 0.0044
Onchocerca volvulus 0.0145 0.0135 0.2192
Echinococcus multilocularis serine protein kinase ATM 0.1637 0.1865 0.1865
Trichomonas vaginalis PIKK family atypical protein kinase 0.4674 0.5384 0.5382
Loa Loa (eye worm) phosphatidylinositol 3 0.0558 0.0614 0.0614
Brugia malayi Delta serrate ligand family protein 0.0145 0.0135 0.0135
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.8656 1 1
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Schistosoma mansoni hypothetical protein 0.0145 0.0135 0.0135
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0558 0.0614 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.6438 0.7429 0.7427
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0558 0.0614 0.0609
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0558 0.0614 0.0614
Brugia malayi Animal haem peroxidase family protein 0.0448 0.0486 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.5121 0.5903 0.59
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0558 0.0614 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.4667 0.5376 0.5373
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0558 0.0614 0.0614
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0558 0.0614 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.5172 0.5962 0.596
Echinococcus multilocularis fk506 binding protein 0.0089 0.007 0.007
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1266 0.1434 0.1434
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0089 0.007 0.007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1079 0.1217 0.1178
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0558 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Brugia malayi EGF-like domain containing protein 0.0145 0.0135 0.0135
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0558 0.0614 0.0609
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0089 0.007 0.0025
Echinococcus multilocularis neural cadherin 0.0145 0.0135 0.0135
Brugia malayi Calcium binding EGF domain containing protein 0.0145 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.1824 0.2081 0.2081
Loa Loa (eye worm) hypothetical protein 0.1266 0.1434 0.1434
Schistosoma mansoni serine/threonine kinase 0.0035 0.0007 0.0007
Leishmania major phosphatidylinositol kinase, putative 0.0558 0.0614 0.0549
Loa Loa (eye worm) phosphatidylinositol 3 0.0558 0.0614 0.0614
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0558 0.0614 0.0827
Loa Loa (eye worm) phosphatidylinositol 3 0.0558 0.0614 0.0614
Brugia malayi Pre-SET motif family protein 0.0029 0.0001 0.0001
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1637 0.1865 0.1865
Onchocerca volvulus 0.004 0.0014 0.0223
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Loa Loa (eye worm) AGC/AKT protein kinase 0.0107 0.0092 0.0092
Onchocerca volvulus Peroxidase homolog 0.0448 0.0486 0.7911
Trichomonas vaginalis PIKK family atypical protein kinase 0.8656 1 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0101 0.0084 0.0084
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0089 0.007 0.5
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0015 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0011 0.0005
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0558 0.0614 0.0549
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0001 0.0001
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0035 0.0007 0.0007
Brugia malayi FAT domain containing protein 0.1266 0.1434 0.1434
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0089 0.007 0.007
Loa Loa (eye worm) phosphatidylinositol kinase 0.0558 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.6438 0.7429 0.7427
Trichomonas vaginalis PIKK family atypical protein kinase 0.5806 0.6697 0.6695
Onchocerca volvulus Peroxidasin homolog 0.0448 0.0486 0.7911
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0092 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.6438 0.7429 0.7427
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0558 0.0614 0.0572
Onchocerca volvulus 0.0145 0.0135 0.2192
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0558 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.6438 0.7429 0.7427
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0558 0.0614 0.0614
Brugia malayi Protein kinase domain containing protein 0.0035 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0558 0.0614 0.0614
Echinococcus multilocularis protein kinase c epsilon type 0.0035 0.0007 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0558 0.0614 0.0608
Brugia malayi GCC2 and GCC3 family protein 0.0145 0.0135 0.0135
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0089 0.007 0.007
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0035 0.0007 0.0007
Echinococcus multilocularis serine:threonine protein kinase N2 0.0035 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0558 0.0614 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.6438 0.7429 0.7427
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0558 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0035 0.0007 0.0007
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0558 0.0614 1
Brugia malayi Cadherin domain containing protein 0.0145 0.0135 0.0135
Brugia malayi Pre-SET motif family protein 0.0203 0.0203 0.0203
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0015 0.0009
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0558 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0558 0.0614 0.0572
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0089 0.007 0.0063
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0076 0.0056 0.0056
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0075 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.8656 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1824 0.2081 0.2802
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Toxoplasma gondii AGC kinase 0.0101 0.0084 0.0113
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0089 0.007 0.0063
Loa Loa (eye worm) hypothetical protein 0.0558 0.0614 0.0614
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0015 0.0237
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1266 0.1434 0.1434
Entamoeba histolytica protein kinase, putative 0.0101 0.0084 0.0077
Echinococcus multilocularis chromobox protein 1 0.0068 0.0046 0.0046
Echinococcus granulosus serine protein kinase ATM 0.1637 0.1865 0.1865
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0089 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0145 0.0135 0.0135
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0558 0.0614 0.0614
Echinococcus granulosus delta-like protein 1 0.0145 0.0135 0.0135
Echinococcus multilocularis serine:threonine protein kinase 38 0.0035 0.0007 0.0007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0203 0.0203
Loa Loa (eye worm) animal heme peroxidase 0.0448 0.0486 0.0486
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0558 0.0614 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Loa Loa (eye worm) animal heme peroxidase 0.0448 0.0486 0.0486
Echinococcus multilocularis nervana 2 0.0066 0.0044 0.0044
Echinococcus granulosus protein jagged 2 0.0145 0.0135 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0007 0.0007
Echinococcus granulosus Protein kinase C brain isozyme 0.0035 0.0007 0.0007
Giardia lamblia Kinase, AGC PKA 0.0067 0.0045 0.0045
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1637 0.1865 0.1859
Onchocerca volvulus Dual oxidase homolog 0.0448 0.0486 0.7911
Entamoeba histolytica hypothetical protein 0.0558 0.0614 0.0608
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Schistosoma mansoni immunophilin 0.0089 0.007 0.007
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0558 0.0614 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.6438 0.7429 0.7427
Trichomonas vaginalis PIKK family atypical protein kinase 0.1637 0.1865 0.186
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0558 0.0614 0.0614
Schistosoma mansoni slit 0.0145 0.0135 0.0135
Giardia lamblia High cysteine protein 0.0145 0.0135 0.0135
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0558 0.0614 0.0614
Schistosoma mansoni hypothetical protein 0.0145 0.0135 0.0135
Brugia malayi EGF-like domain containing protein 0.0145 0.0135 0.0135
Loa Loa (eye worm) phosphatidylinositol 3 0.2903 0.3332 0.3332
Loa Loa (eye worm) hypothetical protein 0.1637 0.1865 0.1865
Trichomonas vaginalis PIKK family atypical protein kinase 0.4667 0.5376 0.5373
Echinococcus granulosus nervana 2 0.0066 0.0044 0.0044
Mycobacterium leprae conserved hypothetical protein 0.0558 0.0614 0.5
Echinococcus granulosus neurogenic locus notch protein 4 0.0145 0.0135 0.0135
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0007 0.0001
Leishmania major phosphatidylinositol 3-kinase, putative 0.0558 0.0614 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.6885 0.7947 0.7946
Trichomonas vaginalis PIKK family atypical protein kinase 0.4674 0.5384 0.5382
Leishmania major hypothetical protein, unknown function 0.0558 0.0614 0.0549
Echinococcus granulosus neurogenic locus notch protein 0.0145 0.0135 0.0135
Brugia malayi Animal haem peroxidase family protein 0.0448 0.0486 0.0486
Echinococcus multilocularis serine threonine protein kinase 0.0035 0.0007 0.0007
Brugia malayi Protein kinase domain containing protein 0.0107 0.0092 0.0092
Schistosoma mansoni atypical protein kinase C 0.0035 0.0007 0.0007
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0066 0.0044 0.0044
Echinococcus multilocularis neurogenic locus protein delta 0.0145 0.0135 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0558 0.0614 0.0609
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.4093 0.4712 0.4675
Entamoeba histolytica PH domain containing protein kinase, putative 0.0074 0.0052 0.0045
Plasmodium vivax SET domain protein, putative 0.0029 0.0001 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.6885 0.7947 0.7946
Brugia malayi Animal haem peroxidase family protein 0.0448 0.0486 0.0486
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0558 0.0614 0.0608
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0558 0.0614 0.0827
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1637 0.1865 0.1865
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0558 0.0614 0.0614
Echinococcus granulosus serine threonine protein kinase nrc 0.0067 0.0045 0.0045
Brugia malayi notch-like transmembrane receptor 0.0145 0.0135 0.0135
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.8656 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0558 0.0614 0.0609
Mycobacterium tuberculosis Conserved hypothetical protein 0.0558 0.0614 0.5
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0558 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2903 0.3332 0.3302
Echinococcus multilocularis neurogenic locus notch protein 0.0145 0.0135 0.0135
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0558 0.0614 0.0549
Entamoeba histolytica protein kinase rad3, putative 0.1637 0.1865 0.1859
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0558 0.0614 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.4674 0.5384 0.5382
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0558 0.0614 0.0609
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0089 0.007 0.007
Brugia malayi Protein kinase domain containing protein 0.0035 0.0007 0.0007
Leishmania major phosphatidylinositol kinase related protein, putative 0.0558 0.0614 0.0549
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.5619 0.648 0.6478
Echinococcus multilocularis neurogenic locus notch protein 4 0.0145 0.0135 0.0135
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0558 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Echinococcus multilocularis peroxidasin 0.0448 0.0486 0.0486
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0558 0.0614 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0014 0.0014
Echinococcus multilocularis serine:threonine protein kinase N2 0.0035 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.2903 0.3332 0.3328
Echinococcus granulosus protein jagged 1 0.0145 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.2903 0.3332 0.3328
Loa Loa (eye worm) AGC/PKN protein kinase 0.0035 0.0007 0.0007
Giardia lamblia Hypothetical protein 0.0558 0.0614 0.0614
Echinococcus granulosus jumonji domain containing protein 0.004 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0448 0.0486 0.0486
Onchocerca volvulus 0.0145 0.0135 0.2192
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.8656 1 1
Brugia malayi EGF-like domain containing protein 0.0145 0.0135 0.0135
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.8656 1 1
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0053 0.0053
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0046 0.004
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0035 0.0007 0.0007
Echinococcus granulosus chromobox protein 1 0.0068 0.0046 0.0046
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0089 0.007 0.007
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0558 0.0614 0.0614
Schistosoma mansoni hypothetical protein 0.0145 0.0135 0.0135
Brugia malayi jmjC domain containing protein 0.0093 0.0075 0.0075
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0046 0.0046
Loa Loa (eye worm) notch protein 0.0145 0.0135 0.0135
Echinococcus granulosus nervana 2 0.0066 0.0044 0.0044
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.8656 1 1
Schistosoma mansoni notch 0.0145 0.0135 0.0135
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0558 0.0614 0.0572
Brugia malayi Animal haem peroxidase family protein 0.0448 0.0486 0.0486
Onchocerca volvulus 0.0448 0.0486 0.7911
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2903 0.3332 0.3285
Brugia malayi EGF-like domain containing protein 0.0145 0.0135 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.5172 0.5962 0.596
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0035 0.0007 0.0007
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0558 0.0614 0.0609
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.8656 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0558 0.0614 0.0609
Entamoeba histolytica protein kinase, putative 0.0107 0.0092 0.0085
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0067 0.0045 0.0045
Trichomonas vaginalis fk506-binding protein, putative 0.0089 0.007 0.0063
Brugia malayi chromobox protein homolog 3 0.0038 0.0011 0.0011
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2903 0.3332 0.3332
Echinococcus granulosus NDR protein kinase 0.0035 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.6885 0.7947 0.7946
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0558 0.0614 0.0614
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0007 0.0007
Leishmania major phosphatidylinositol 3-kinase, putative 0.2903 0.3332 0.3285
Loa Loa (eye worm) animal heme peroxidase 0.0448 0.0486 0.0486
Entamoeba histolytica hypothetical protein 0.0558 0.0614 0.0608
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0558 0.0614 0.0608
Entamoeba histolytica PH domain containing protein kinase, putative 0.0074 0.0052 0.0045
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.2903 0.3332 0.3328
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1637 0.1865 0.1808
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0558 0.0614 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1637 0.1865 0.1865
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0558 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.6885 0.7947 0.7946
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0558 0.0614 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0558 0.0614 0.0609
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0558 0.0614 0.0614
Brugia malayi Blistered cuticle protein 3 0.0448 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0558 0.0614 0.0549
Onchocerca volvulus Peroxidasin homolog 0.0448 0.0486 0.7911
Echinococcus granulosus Glutaredoxin protein 5 0.0066 0.0044 0.0044
Schistosoma mansoni notch 0.0145 0.0135 0.0135
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0558 0.0614 0.0608
Loa Loa (eye worm) hypothetical protein 0.0145 0.0135 0.0135
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0092 0.0085
Schistosoma mansoni notch 0.0145 0.0135 0.0135
Trypanosoma cruzi target of rapamycin kinase 3 0.6892 0.7955 0.7946

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1 nM In vitro agonist activity for estrogen receptor alpha expressed in COS-1 cells ChEMBL. 15713407
EC50 (functional) = 1 nM In vitro agonist activity for estrogen receptor alpha expressed in COS-1 cells ChEMBL. 15713407
EC50 (functional) = 6 nM In vitro agonist activity for estrogen receptor beta expresssed in COS-1 cells ChEMBL. 15713407
EC50 (functional) = 6 nM In vitro agonist activity for estrogen receptor beta expresssed in COS-1 cells ChEMBL. 15713407

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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