Detailed information for compound 319717

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 250.337 | Formula: C14H22N2O2
  • H donors: 0 H acceptors: 2 LogP: 4.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CN1CCC1C(=O)O[C@H](CC1CCCCC1)C
  • InChi: 1S/C14H22N2O2/c1-11(9-12-5-3-2-4-6-12)18-14(17)13-7-8-16(13)10-15/h11-13H,2-9H2,1H3/t11-,13?/m0/s1
  • InChiKey: BEMWXCUECCHZDO-AMGKYWFPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin H Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 2b cathepsin H 335 aa 340 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus multidrug resistance associated protein 7 0.002 0.0009 0.0009
Mycobacterium tuberculosis Hypothetical protein 0.0979 0.2045 0.2044
Brugia malayi Cathepsin L-like precursor 0.0046 0.0065 0.0064
Schistosoma mansoni purine nucleoside phosphorylase 0.4726 1 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.002 0.0009 0.0044
Giardia lamblia Hypothetical protein 0.002 0.0009 0.0001
Giardia lamblia Cysteine protease 0.002 0.0009 0.0001
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.002 0.0009 0.0043
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0979 0.2045 0.2038
Entamoeba histolytica ATP-binding cassette protein, putative 0.002 0.0009 0.0043
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.002 0.0009 0.0043
Leishmania major ABC-thiol transporter 0.002 0.0009 0.0043
Brugia malayi cathepsin F-like cysteine proteinase 0.0027 0.0024 0.0023
Entamoeba histolytica ATP-binding cassette protein, putative 0.002 0.0009 0.0043
Loa Loa (eye worm) uridine phosphorylase 0.0979 0.2045 0.2581
Giardia lamblia Cathepsin B precursor 0.002 0.0009 0.0001
Brugia malayi cathepsin L-like precursor 0.0046 0.0065 0.0064
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.002 0.0009 0.0044
Entamoeba histolytica ATP-binding cassette protein, putative 0.002 0.0009 0.0043
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0009 0.0044
Echinococcus granulosus cathepsin b 0.0181 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0073 0.0122 0.0154
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.0351 0.035
Schistosoma mansoni multidrug resistance protein 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0122 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0979 0.2045 0.2044
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0016 0.0001 0.0001
Schistosoma mansoni multidrug resistance protein 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0122 0.0121
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.0065 0.0315
Onchocerca volvulus 0.0073 0.0122 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0009 0.0009
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0009 0.0009
Entamoeba histolytica cysteine protease, putative 0.0047 0.0066 0.0321
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0979 0.2045 0.2044
Echinococcus granulosus purine nucleoside phosphorylase 0.4726 1 1
Leishmania major cathepsin L-like protease 0.0073 0.0122 0.0593
Leishmania major pentamidine resistance protein 1 0.002 0.0009 0.0043
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0024 0.0072
Onchocerca volvulus 0.0073 0.0122 0.0121
Toxoplasma gondii phosphorylase family protein 0.0979 0.2045 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0009 0.0009
Echinococcus granulosus purine nucleoside phosphorylase 0.4726 1 1
Giardia lamblia Cathepsin L precursor 0.002 0.0009 0.0001
Echinococcus granulosus uridine phosphorylase 1 0.0979 0.2045 0.2045
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.4726 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0066 0.0066
Loa Loa (eye worm) cysteine protease 0.0073 0.0122 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.002 0.0009 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0009
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0009 0.0044
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0979 0.2045 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0066 0.0321
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0122 0.0121
Plasmodium falciparum serine repeat antigen 9 0.002 0.0009 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0046 0.0065 0.0082
Echinococcus granulosus purine nucleoside phosphorylase 0.4726 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0009 0.0009
Echinococcus multilocularis purine nucleoside phosphorylase 0.4726 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0009 0.0009
Entamoeba histolytica cysteine protease, putative 0.0073 0.0122 0.0593
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.0115 0.0519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0065 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0122 0.0552
Echinococcus granulosus cathepsin l1 0.0073 0.0122 0.0122
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0016 0.0001 0.0001
Schistosoma mansoni uridine phosphorylase 0.0979 0.2045 0.2044
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0009 0.0043
Schistosoma mansoni cathepsin F (C01 family) 0.0046 0.0065 0.0064
Echinococcus multilocularis uridine phosphorylase 1 0.0979 0.2045 0.2045
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0066 0.0321
Giardia lamblia Cathepsin B precursor 0.007 0.0115 0.0106
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0009 0.0009
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.002 0.0009 0.0044
Giardia lamblia Cysteine protease 0.002 0.0009 0.0001
Plasmodium falciparum serine repeat antigen 2 0.002 0.0009 0.0044
Brugia malayi Cathepsin L-like precursor 0.0073 0.0122 0.0121
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0979 0.2045 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0073 0.0122 0.0593
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0012
Loa Loa (eye worm) fibroinase 0.0073 0.0122 0.0154
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.002 0.0009 0.0012
Schistosoma mansoni methylthioadenosine phosphorylase 0.0979 0.2045 0.2044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.0351 0.035
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.0066 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Entamoeba histolytica cysteine protease, putative 0.0047 0.0066 0.0321
Entamoeba histolytica papain family cysteine protease domain containing protein 0.002 0.0009 0.0044
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 0.0351 0.1678
Mycobacterium ulcerans purine nucleoside phosphorylase 0.4726 1 1
Giardia lamblia Multidrug resistance-associated protein 1 0.002 0.0009 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0122 0.0552
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0012
Brugia malayi Cathepsin L-like precursor 0.0027 0.0024 0.0023
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0016 0.0001 0.0001
Echinococcus granulosus multidrug resistance associated protein 1 0.002 0.0009 0.0009
Brugia malayi fibroinase precursor 0.002 0.0009 0.0009
Toxoplasma gondii cathepsin CPL 0.0073 0.0122 0.0593
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0979 0.2045 1
Schistosoma mansoni cathepsin F (C01 family) 0.0073 0.0122 0.0121
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0012
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.0122 0.0552
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0115 0.0115
Echinococcus granulosus purine nucleoside phosphorylase 0.4726 1 1
Echinococcus multilocularis cathepsin L 0.002 0.0009 0.0009
Brugia malayi ABC transporter transmembrane region family protein 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Giardia lamblia Cysteine protease 0.002 0.0009 0.0001
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.0115 0.0519
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0009 0.0009
Entamoeba histolytica cysteine protease, putative 0.002 0.0009 0.0044
Entamoeba histolytica cysteine protease, putative 0.0047 0.0066 0.0321
Toxoplasma gondii Purine nucleoside phosphorylase 0.0979 0.2045 1
Schistosoma mansoni cathepsin C 0.002 0.0009 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0066 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Echinococcus granulosus cathepsin L 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0009 0.0009
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0979 0.2045 0.2044
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0979 0.2045 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0073 0.0122 0.0122
Giardia lamblia Cysteine protease 0.002 0.0009 0.0001
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0066 0.0066
Entamoeba histolytica cysteine protease, putative 0.002 0.0009 0.0044
Onchocerca volvulus 0.0046 0.0065 0.0064
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0009 0.0009
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0066 0.0066
Chlamydia trachomatis AMP nucleosidase 0.0979 0.2045 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0016 0.0001 0.0001
Echinococcus granulosus purine nucleoside phosphorylase 0.4726 1 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0066 0.0321
Toxoplasma gondii cathepsin CPC1 0.002 0.0009 0.0044
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0066 0.0279
Echinococcus multilocularis purine nucleoside phosphorylase 0.4726 1 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0066 0.0321
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0012
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0009 0.0012
Echinococcus multilocularis cysteine protease 0.0073 0.0122 0.0122
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.002 0.0009 0.0012
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0066 0.0321
Brugia malayi Cathepsin L-like precursor 0.0073 0.0122 0.0121
Schistosoma mansoni purine nucleoside phosphorylase 0.4726 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0012
Entamoeba histolytica hypothetical protein 0.002 0.0009 0.0044
Plasmodium falciparum serine repeat antigen 7 0.002 0.0009 0.0044
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0016 0.0001 0.0001
Plasmodium falciparum serine repeat antigen 6 0.002 0.0009 0.0044
Giardia lamblia Cathepsin L precursor 0.002 0.0009 0.0001
Schistosoma mansoni methylthioadenosine phosphorylase 0.0979 0.2045 0.2044
Giardia lamblia Cathepsin L precursor 0.002 0.0009 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0122 0.0552
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0979 0.2045 0.2581
Trypanosoma cruzi cysteine protease, putative 0.0047 0.0066 0.0279
Schistosoma mansoni cathepsin S (C01 family) 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0009 0.0009
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.002 0.0009 0.0044
Leishmania major cathepsin L-like protease 0.0073 0.0122 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Brugia malayi cathepsin B-like cysteine proteinase 0.0181 0.0351 0.035
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0027 0.0024 0.0023
Plasmodium falciparum serine repeat antigen 1 0.002 0.0009 0.0044
Giardia lamblia UPL-1 0.0979 0.2045 0.2038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0066 0.0279
Mycobacterium tuberculosis Conserved hypothetical protein 0.0979 0.2045 0.2044
Giardia lamblia Cathepsin L precursor 0.002 0.0009 0.0001
Echinococcus granulosus multidrug resistance protein 1 0.0016 0.0001 0.0001
Leishmania major cysteine peptidase A (CPA) 0.0073 0.0122 0.0593
Plasmodium vivax vivapain-2 0.0073 0.0122 0.0593
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0979 0.2045 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0009
Entamoeba histolytica cysteine protease, putative 0.002 0.0009 0.0044
Plasmodium vivax vivapain-2 0.0073 0.0122 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.0066 0.0279
Brugia malayi uridine phosphorylase family protein 0.0979 0.2045 0.2044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.0351 0.035
Giardia lamblia Cathepsin L precursor 0.002 0.0009 0.0001
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.0024 0.0072
Schistosoma mansoni multidrug resistance protein 0.002 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0122 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0979 0.2045 0.2044
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0073 0.0122 0.0121
Entamoeba histolytica cysteine protease, putative 0.0047 0.0066 0.0321
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0122 0.0593
Echinococcus granulosus cathepsin l1 0.0046 0.0065 0.0065
Plasmodium vivax unspecified product 0.002 0.0009 0.0044
Brugia malayi cathepsin L-like cysteine proteinase 0.002 0.0009 0.0009
Entamoeba histolytica cysteine protease, putative 0.0047 0.0066 0.0321
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0122 0.0552
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.002 0.0009 0.0044
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0012
Echinococcus multilocularis cysteine protease 0.0073 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.003
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 0.0351 0.035
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.3747 0.7923 0.7923
Trypanosoma brucei uridine phosphorylase 0.0979 0.2045 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0009 0.0001
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0016 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0122 0.0552
Brugia malayi Cathepsin L-like cysteine proteinase 0.0046 0.0065 0.0064
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0009 0.0009
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.002 0.0009 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0011
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0979 0.2045 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0073 0.0122 0.0122
Entamoeba histolytica cysteine protease, putative 0.0047 0.0066 0.0321
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.002 0.0009 0.0044
Treponema pallidum pfs protein (pfs) 0.0979 0.2045 0.5
Brugia malayi cathepsin L precursor 0.002 0.0009 0.0009
Echinococcus granulosus purine nucleoside phosphorylase 0.4726 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0073 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.003
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0073 0.0122 0.0593
Echinococcus granulosus cathepsin L 0.0047 0.0066 0.0066
Echinococcus multilocularis cathepsin b 0.0181 0.0351 0.0351
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0979 0.2045 0.2044
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0066 0.0066
Leishmania major cathepsin L-like protease 0.0073 0.0122 0.0593
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0122 0.0593
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.4726 1 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0009 0.0044
Schistosoma mansoni uridine phosphorylase 0.0979 0.2045 0.2044
Echinococcus multilocularis multidrug resistance protein 1 0.0016 0.0001 0.0001
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0979 0.2045 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0122 0.0121
Entamoeba histolytica cysteine protease, putative 0.002 0.0009 0.0044
Entamoeba histolytica multidrug resistance protein, putative 0.002 0.0009 0.0043
Entamoeba histolytica cysteine protease, putative 0.002 0.0009 0.0044
Loa Loa (eye worm) cathepsin B 0.007 0.0115 0.0145
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.002 0.0009 0.0044
Leishmania major cathepsin L-like protease 0.0073 0.0122 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0009 0.0009
Echinococcus multilocularis purine nucleoside phosphorylase 0.4726 1 1
Brugia malayi multidrug resistance related protein 1 0.002 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0122 0.0552
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0979 0.2045 0.2044
Giardia lamblia Cathepsin L precursor 0.002 0.0009 0.0001
Giardia lamblia Cathepsin B precursor 0.007 0.0115 0.0106
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0979 0.2045 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0122 0.0552
Loa Loa (eye worm) ctsf protein 0.0073 0.0122 0.0154
Brugia malayi Cathepsin L-like precursor 0.0073 0.0122 0.0121
Toxoplasma gondii cathepsin B 0.007 0.0115 0.056
Giardia lamblia Cathepsin L-like protease 0.002 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0046 0.0065 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0009 0.0009
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0016 0.0001 0.0001
Echinococcus granulosus purine nucleoside phosphorylase 0.4726 1 1
Brugia malayi Cathepsin L-like precursor 0.0073 0.0122 0.0121
Toxoplasma gondii phosphorylase family protein 0.0979 0.2045 1
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0066 0.0279
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0009 0.0044
Giardia lamblia Cathepsin L-like protease 0.002 0.0009 0.0001
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0046 0.0065 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0122 0.0552
Plasmodium vivax unspecified product 0.0047 0.0066 0.0321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0122 0.0552
Brugia malayi Cathepsin L-like precursor 0.0073 0.0122 0.0121
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0122 0.0552
Giardia lamblia Cathepsin B precursor 0.002 0.0009 0.0001
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0979 0.2045 0.2038
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0073 0.0122 0.0122
Echinococcus granulosus purine nucleoside phosphorylase 0.4726 1 1
Brugia malayi Cathepsin L-like precursor 0.0073 0.0122 0.0121
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0009 0.0012
Onchocerca volvulus Cathepsin L homolog 0.002 0.0009 0.0009
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0979 0.2045 1
Onchocerca volvulus Cathepsin L homolog 0.0073 0.0122 0.0121
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.4726 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.002 0.0009 0.0009
Onchocerca volvulus 0.0073 0.0122 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0122 0.0121
Echinococcus granulosus multidrug resistance protein 1 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0012
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.002 0.0009 0.0001
Brugia malayi cahepsin L-like non-peptiedase homolog 0.002 0.0009 0.0009
Echinococcus multilocularis purine nucleoside phosphorylase 0.3747 0.7923 0.7923
Schistosoma mansoni cathepsin B (C01 family) 0.002 0.0009 0.0009
Toxoplasma gondii preprocathepsin c precursor, putative 0.002 0.0009 0.0044
Echinococcus granulosus multidrug resistance protein 1 0.0016 0.0001 0.0001
Giardia lamblia Hypothetical protein 0.002 0.0009 0.0001
Echinococcus granulosus cathepsin L cysteine proteinase 0.0073 0.0122 0.0122
Entamoeba histolytica cysteine protease, putative 0.002 0.0009 0.0044
Entamoeba histolytica cysteine proteinase 2 0.0047 0.0066 0.0321
Onchocerca volvulus 0.0073 0.0122 0.0121
Plasmodium vivax vivapain-3 0.0047 0.0066 0.0321
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0009 0.0009
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.002 0.0009 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Onchocerca volvulus 0.002 0.0009 0.0009
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0016 0.0001 0.0001
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0009 0.0009
Leishmania major methylthioadenosine phosphorylase, putative 0.0979 0.2045 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0073 0.0122 0.0593
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0122 0.0552
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0009
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0979 0.2045 0.2044
Echinococcus multilocularis cathepsin L 0.0047 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0009 0.0009
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0009 0.0001
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0979 0.2045 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0122 0.0552
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.002 0.0009 0.0044
Brugia malayi Cathepsin L-like precursor 0.0046 0.0065 0.0064
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0066 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0009 0.0009
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0066 0.0279
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.007 0.0115 0.056
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0073 0.0122 0.0122
Entamoeba histolytica cysteine protease, putative 0.0047 0.0066 0.0321
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.0066 0.0321
Giardia lamblia Encystation-specific protease 0.002 0.0009 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0122 0.0121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0122 0.0552
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.0115 0.0115
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.3747 0.7923 1
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.4726 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0016 0.0001 0.0001
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0979 0.2045 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0979 0.2045 0.2044
Echinococcus multilocularis purine nucleoside phosphorylase 0.3747 0.7923 0.7923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0065 0.0064
Giardia lamblia Cathepsin B precursor 0.002 0.0009 0.0001
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.002 0.0009 0.0044
Onchocerca volvulus 0.0073 0.0122 0.0121
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0073 0.0122 0.0154
Plasmodium falciparum serine repeat antigen 8 0.002 0.0009 0.0044
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.4726 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0009 0.0001
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.002 0.0009 0.0044
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.003
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0009
Onchocerca volvulus 0.0073 0.0122 0.0121
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0979 0.2045 0.2044
Plasmodium falciparum serine repeat antigen 4 0.002 0.0009 0.0044
Entamoeba histolytica cysteine protease, putative 0.0047 0.0066 0.0321
Leishmania major nucleoside phosphorylase-like protein 0.0979 0.2045 1
Echinococcus multilocularis multidrug resistance associated protein 1 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0122 0.0121
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.0122 0.0121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.002 0.0009 0.0009
Giardia lamblia Multidrug resistance-associated protein 1 0.002 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0046 0.0065 0.0082
Schistosoma mansoni multidrug resistance protein 0.002 0.0009 0.0009
Onchocerca volvulus 0.0073 0.0122 0.0121
Giardia lamblia Cathepsin B precursor 0.002 0.0009 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Giardia lamblia MRP-like ABC transporter 0.002 0.0009 0.0001
Schistosoma mansoni cathepsin s 0.0027 0.0024 0.0023
Echinococcus multilocularis cathepsin b 0.0181 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0181 0.0351 0.0443
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.002 0.0009 0.0044
Onchocerca volvulus Cathepsin L homolog 0.0073 0.0122 0.0121
Echinococcus granulosus methylthioadenosine phosphorylase 0.0979 0.2045 0.2045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0016 0.0001 0.0001
Brugia malayi MTAP 0.0979 0.2045 0.2044
Leishmania major p-glycoprotein e 0.002 0.0009 0.0043
Treponema pallidum uridine phosphorylase (udp) 0.0979 0.2045 0.5
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.002 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Entamoeba histolytica ATP-binding cassette protein, putative 0.002 0.0009 0.0043
Echinococcus multilocularis purine nucleoside phosphorylase 0.4726 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0009 0.0009
Giardia lamblia Cathepsin B precursor 0.002 0.0009 0.0001
Entamoeba histolytica cysteine protease, putative 0.0047 0.0066 0.0321
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0009 0.0009
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0979 0.2045 1
Entamoeba histolytica ABC transporter, putative 0.002 0.0009 0.0043
Plasmodium falciparum serine repeat antigen 3 0.002 0.0009 0.0044
Plasmodium vivax vivapain-1 0.0047 0.0066 0.0321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0122 0.0552
Giardia lamblia Cathepsin B precursor 0.007 0.0115 0.0106
Leishmania major cathepsin L-like protease 0.0073 0.0122 0.0593
Leishmania major cathepsin L-like protease 0.0073 0.0122 0.0593
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Plasmodium falciparum serine repeat antigen 5 0.002 0.0009 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.0009
Onchocerca volvulus Cathepsin F homolog 0.0073 0.0122 0.0121
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0979 0.2045 1
Leishmania major cathepsin L-like protease 0.0073 0.0122 0.0593
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0979 0.2045 0.2044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0122 0.0121
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0009 0.0009
Schistosoma mansoni methylthioadenosine phosphorylase 0.0979 0.2045 0.2044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0066 0.0279
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0073 0.0122 0.0154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0122 0.0121
Echinococcus multilocularis multidrug resistance associated protein 7 0.002 0.0009 0.0009
Echinococcus granulosus cathepsin b 0.0181 0.0351 0.0351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Echinococcus multilocularis purine nucleoside phosphorylase 0.4726 1 1
Leishmania major cathepsin L-like protease 0.0073 0.0122 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0122 0.0121
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.002 0.0009 0.0043
Entamoeba histolytica cysteine protease, putative 0.0047 0.0066 0.0321
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0016 0.0001 0.0001
Toxoplasma gondii cathepsin CPC2 0.002 0.0009 0.0044
Giardia lamblia ABC transporter, putative 0.002 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0012
Echinococcus multilocularis purine nucleoside phosphorylase 0.4726 1 1
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0979 0.2045 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0073 0.0122 0.0121
Plasmodium falciparum purine nucleoside phosphorylase 0.0979 0.2045 1
Plasmodium vivax unspecified product 0.0027 0.0024 0.0115
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0979 0.2045 0.2045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0024 0.003
Entamoeba histolytica hypothetical protein 0.0979 0.2045 1
Echinococcus granulosus cysteine protease 0.0047 0.0066 0.0066
Schistosoma mansoni cathepsin F (C01 family) 0.0073 0.0122 0.0121
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0016 0.0001 0.0001

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.048 nM Inhibitory concentration against human cathepsin K using 10 uM Cbz-Phe-Arg-AMC ChEMBL. 15780613
IC50 (binding) = 0.048 nM Inhibitory concentration against human cathepsin K using 10 uM Cbz-Phe-Arg-AMC ChEMBL. 15780613
IC50 (binding) = 0.71 nM Inhibitory concentration against human cathepsin L using 5 uM Cbz-Phe-Arg-AMC ChEMBL. 15780613
IC50 (binding) = 0.71 nM Inhibitory concentration against human cathepsin L using 5 uM Cbz-Phe-Arg-AMC ChEMBL. 15780613
IC50 (binding) = 2.4 nM Inhibitory concentration against human cathepsin B using 10 uM Cbz-Phe-Arg-AMC ChEMBL. 15780613
IC50 (binding) = 2.4 nM Inhibitory concentration against human cathepsin B using 10 uM Cbz-Phe-Arg-AMC ChEMBL. 15780613
IC50 (binding) = 40 nM Inhibitory concentration against human cathepsin H using 50 uM L-Arg-beta-naphthalamide ChEMBL. 15780613
IC50 (binding) = 40 nM Inhibitory concentration against human cathepsin H using 50 uM L-Arg-beta-naphthalamide ChEMBL. 15780613

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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