Detailed information for compound 322589

Basic information

Technical information
  • TDR Targets ID: 322589
  • Name: N-[4-[(5-bromopyridin-2-yl)amino]-1-(4-methyl piperazin-1-yl)-1,4-dioxobutan-2-yl]-4-(2-sul famoylphenyl)benzamide
  • MW: 629.525 | Formula: C27H29BrN6O5S
  • H donors: 3 H acceptors: 6 LogP: 1.53 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN1CCN(CC1)C(=O)C(NC(=O)c1ccc(cc1)c1ccccc1S(=O)(=O)N)CC(=O)Nc1ccc(cn1)Br
  • InChi: 1S/C27H29BrN6O5S/c1-33-12-14-34(15-13-33)27(37)22(16-25(35)32-24-11-10-20(28)17-30-24)31-26(36)19-8-6-18(7-9-19)21-4-2-3-5-23(21)40(29,38)39/h2-11,17,22H,12-16H2,1H3,(H,31,36)(H2,29,38,39)(H,30,32,35)
  • InChiKey: XSKHIJAFGVJFOR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-[(5-bromo-2-pyridyl)amino]-1-(4-methylpiperazine-1-carbonyl)-3-oxo-propyl]-4-(2-sulfamoylphenyl)benzamide
  • N-[3-[(5-bromo-2-pyridyl)amino]-1-[(4-methyl-1-piperazinyl)-oxomethyl]-3-oxopropyl]-4-(2-sulfamoylphenyl)benzamide
  • N-[4-[(5-bromopyridin-2-yl)amino]-1-(4-methylpiperazin-1-yl)-1,4-dioxo-butan-2-yl]-4-(2-sulfamoylphenyl)benzamide
  • N-[3-[(5-bromo-2-pyridyl)amino]-3-keto-1-(4-methylpiperazine-1-carbonyl)propyl]-4-(2-sulfamoylphenyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.071 0.3762 0.3761
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0033
Onchocerca volvulus Cyclin L homolog 0.0028 0.0076 0.0312
Loa Loa (eye worm) ACC-1 protein 0.0062 0.0256 0.0256
Schistosoma mansoni opsin-like receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis cyclin G2 0.0028 0.0076 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Trichomonas vaginalis cyclins, putative 0.0199 0.1001 0.8396
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0023 0.0019
Schistosoma mansoni lipoxygenase 0.0117 0.0557 0.0634
Plasmodium vivax cyclin homologue, putative 0.0028 0.0076 0.0676
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Echinococcus multilocularis glycine receptor subunit beta 0.0062 0.0256 0.0291
Plasmodium falciparum cyclin 1 0.0028 0.0076 0.0676
Trichomonas vaginalis clathrin coat assembly protein ap19, putative 0.0165 0.0813 0.6811
Echinococcus granulosus tm gpcr rhodopsin 0.0298 0.1534 0.1719
Schistosoma mansoni hypothetical protein 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0037 0.0122 0.0121
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0195 0.0191
Echinococcus granulosus neuropeptide s receptor 0.0298 0.1534 0.1719
Echinococcus multilocularis cyclin y 0.0028 0.0076 0.0086
Echinococcus granulosus cyclins 0.0117 0.0557 0.0624
Echinococcus granulosus neuropeptide receptor 0.0298 0.1534 0.1719
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0298 0.1534 0.1719
Brugia malayi RE15519p 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0082 0.0366 0.0366
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0024 0.0051 0.0058
Echinococcus granulosus cyclins 0.0117 0.0557 0.0624
Trichomonas vaginalis cyclin B, putative 0.0199 0.1001 0.8396
Loa Loa (eye worm) G-protein coupled receptor 0.0298 0.1534 0.1534
Brugia malayi Cytochrome P450 family protein 0.0018 0.0019 0.0019
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.1001 0.1001
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0001 0.0001
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.017 0.017
Echinococcus multilocularis Cyclin L1 0.0028 0.0076 0.0086
Schistosoma mansoni growth hormone secretagogue receptor 0.0298 0.1534 0.1744
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0485 0.2546 0.2853
Onchocerca volvulus 0.0024 0.0051 0.0146
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0062 0.0256 0.0291
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Brugia malayi Serotonin receptor 0.1208 0.646 0.646
Onchocerca volvulus 0.0024 0.0051 0.0146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0298 0.1534 0.1534
Schistosoma mansoni amine GPCR 0.0298 0.1534 0.1744
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0527 0.2772 0.2771
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0029 0.0033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0122 0.0136
Leishmania major hypothetical protein, conserved 0.005 0.0195 0.0191
Entamoeba histolytica hypothetical protein 0.0038 0.0128 0.1018
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0319 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0115 0.0936
Onchocerca volvulus 0.0298 0.1534 1
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) clathrin adaptor complex small chain 0.0165 0.0813 0.0812
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0116 0.0552 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0415
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0062 0.0256 0.0287
Echinococcus multilocularis G protein coupled receptor 139 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0298 0.1534 0.1744
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0164 0.0184
Echinococcus granulosus orexin receptor type 2 0.0298 0.1534 0.1719
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0164 0.0161
Echinococcus granulosus biogenic amine 5HT receptor 0.0298 0.1534 0.1719
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0256 0.0291
Loa Loa (eye worm) hypothetical protein 0.0315 0.1629 0.1629
Echinococcus granulosus neuropeptide FF receptor 2 0.0298 0.1534 0.1719
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0029 0.0033
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0038 0.0128 0.0128
Echinococcus granulosus cyclin A3 4 0.0028 0.0076 0.0085
Trichomonas vaginalis cyclins, putative 0.0117 0.0557 0.4659
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0184 0.021
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0022 0.0019
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0164 0.0164
Plasmodium falciparum cyclin 0.0117 0.0557 0.6767
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0033
Schistosoma mansoni biogenic amine (5HT) receptor 0.0298 0.1534 0.1744
Schistosoma mansoni hypothetical protein 0.0028 0.0076 0.0086
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0298 0.1534 0.1744
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0215
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0024 0.0051 0.0051
Plasmodium vivax SET domain protein, putative 0.0031 0.0088 0.0836
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0022 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0051 0.0051
Schistosoma mansoni cyclin d 0.0028 0.0076 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0076 0.0606
Onchocerca volvulus 0.0031 0.0088 0.0397
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0029 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Schistosoma mansoni neuropeptide receptor 0.0298 0.1534 0.1744
Giardia lamblia GTOR 0.0045 0.0164 0.0958
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0062 0.0256 0.0256
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0122 0.0138
Schistosoma mansoni amine GPCR 0.0298 0.1534 0.1744
Echinococcus granulosus G protein coupled receptor 139 0.0298 0.1534 0.1719
Echinococcus granulosus g protein coupled receptor 0.0298 0.1534 0.1719
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0029 0.0033
Schistosoma mansoni cyclin B3 0.0485 0.2546 0.2895
Schistosoma mansoni cyclin l 0.0028 0.0076 0.0086
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Schistosoma mansoni hypothetical protein 0.0037 0.0122 0.0138
Echinococcus multilocularis neuropeptide receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.164 0.8795 0.8795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0164 0.1353
Toxoplasma gondii cyclin 4, putative 0.0028 0.0076 0.0713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.008 0.0639
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0115 0.0111
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Brugia malayi hypothetical protein 0.0024 0.0051 0.0051
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0028 0.0076 0.0072
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0006 0.0006
Echinococcus granulosus cyclin y 0.0028 0.0076 0.0085
Loa Loa (eye worm) hypothetical protein 0.0032 0.0095 0.0095
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0024 0.0051 0.0058
Schistosoma mansoni cpg binding protein 0.0061 0.025 0.0285
Entamoeba histolytica cyclin C, putative 0.0028 0.0076 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Onchocerca volvulus 0.0038 0.0128 0.0661
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Brugia malayi PXA domain containing protein 0.002 0.0029 0.0029
Onchocerca volvulus 0.0062 0.0256 0.1511
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0062 0.0256 0.0291
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0298 0.1534 0.1744
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0019 0.0015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0006 0.0006
Echinococcus granulosus g-protein coupled receptor 0.0298 0.1534 0.1719
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0024 0.0051 0.0058
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0029 0.0081
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0189 0.0215
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Schistosoma mansoni neuropeptide f receptor 76f 0.0298 0.1534 0.1744
Schistosoma mansoni cyclin B 0.0199 0.1001 0.1138
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0024 0.0051 0.005
Schistosoma mansoni cytochrome P450 0.0018 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Trypanosoma cruzi cyclin, putative 0.0199 0.1001 0.0998
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0164 0.1353
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0108 0.0878
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0062 0.0256 0.0256
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0298 0.1534 0.1744
Schistosoma mansoni cyclin G2 0.0028 0.0076 0.0086
Schistosoma mansoni intermediate filament proteins 0.0027 0.0068 0.0077
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0256 0.0256
Onchocerca volvulus 0.0298 0.1534 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0062 0.0256 0.0256
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0028 0.0076 0.0676
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0195 0.2181
Echinococcus multilocularis neuropeptide receptor A26 0.0298 0.1534 0.1744
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0022 0.0025
Echinococcus granulosus cyclin G2 0.0028 0.0076 0.0085
Echinococcus granulosus lamin 0.0027 0.0068 0.0076
Echinococcus granulosus RUN 0.002 0.0029 0.0032
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0023 0.0023
Echinococcus granulosus cyclin B3 1 0.0117 0.0557 0.0624
Schistosoma mansoni cpg binding protein 0.0057 0.0233 0.0265
Onchocerca volvulus 0.0298 0.1534 1
Echinococcus multilocularis fmrfamide receptor 0.0298 0.1534 0.1744
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0029 0.0033
Leishmania major cytochrome p450-like protein 0.0018 0.0019 0.0015
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0062 0.0256 0.0287
Schistosoma mansoni biogenic amine receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0024 0.0051 0.0051
Leishmania major mitotic cyclin, putative 0.0028 0.0076 0.0072
Schistosoma mansoni neuropeptide receptor 0.0298 0.1534 0.1744
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0062 0.0256 0.0256
Schistosoma mansoni myosin xvIII 0.0298 0.1534 0.1744
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.0557 0.0634
Schistosoma mansoni neuropeptide F-like receptor 0.0298 0.1534 0.1744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0067 0.0534
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0029 0.0029
Echinococcus multilocularis RUN 0.002 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0028 0.0076 0.0075
Brugia malayi Cytochrome P450 family protein 0.0027 0.0066 0.0066
Schistosoma mansoni biogenic amine receptor 0.0298 0.1534 0.1744
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0066 0.0063
Brugia malayi Cation transporter family protein 0.0062 0.0256 0.0256
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0298 0.1534 0.1719
Onchocerca volvulus 0.0298 0.1534 1
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0116 0.0132
Onchocerca volvulus 0.0062 0.0256 0.1511
Echinococcus granulosus axis inhibition protein axin 0.002 0.0029 0.0033
Trypanosoma cruzi cyclin, putative 0.0199 0.1001 0.0998
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0557 0.4659
Onchocerca volvulus 0.0298 0.1534 1
Leishmania major protein kinase, putative 0.0017 0.0017 0.0013
Trichomonas vaginalis cyclins, putative 0.0199 0.1001 0.8396
Brugia malayi sulfakinin receptor protein 0.0298 0.1534 0.1534
Brugia malayi cyclin fold protein 1 variant b 0.0028 0.0076 0.0076
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0256 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0415
Echinococcus multilocularis G1:S specific cyclin D1 0.0028 0.0076 0.0086
Echinococcus granulosus single minded 2 0.0039 0.0135 0.0151
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0076 0.0606
Schistosoma mansoni single-minded 0.0048 0.0184 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0066 0.0522
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.0516 0.626
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0088 0.0099
Brugia malayi hypothetical protein 0.0024 0.0051 0.0051
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0195 0.0191
Trichomonas vaginalis cyclin B, putative 0.0199 0.1001 0.8396
Echinococcus multilocularis microtubule associated protein 2 0.071 0.3763 0.4279
Schistosoma mansoni clathrin coat assembly protein AP17 0.0165 0.0813 0.0924
Schistosoma mansoni lamin 0.0027 0.0068 0.0077
Brugia malayi putative neuropeptide receptor 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.008 0.0353 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0417
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0128 0.0146
Loa Loa (eye worm) cytochrome P450 0.0018 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0028 0.0076 0.0085
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0194
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Giardia lamblia Sigma adaptin 0.0165 0.0813 0.7965
Brugia malayi Pre-SET motif family protein 0.0031 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0199 0.1001 0.1001
Echinococcus granulosus tm gpcr rhodopsin 0.0298 0.1534 0.1719
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0298 0.1534 0.1534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0028 0.0076 0.0713
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0066 0.0066
Echinococcus granulosus sex peptide receptor 0.0298 0.1534 0.1719
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.017 0.0194
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0029 0.0033
Schistosoma mansoni neuropeptide receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Echinococcus granulosus g protein coupled receptor 0.0298 0.1534 0.1719
Loa Loa (eye worm) doublecortin family protein 0.002 0.0029 0.0028
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0139 0.0158
Leishmania major cyclin 0.0199 0.1001 0.0998
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0029 0.0033
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0051 0.0058
Onchocerca volvulus 0.0298 0.1534 1
Echinococcus multilocularis allatostatin A receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0004 0.0004
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0066 0.485
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0298 0.1534 1
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0029 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0076 0.0676
Trypanosoma cruzi clathrin coat assembly protein AP17, putative 0.0165 0.0813 0.0809
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0298 0.1534 0.1744
Onchocerca volvulus Neuropeptide F receptor homolog 0.0298 0.1534 1
Trichomonas vaginalis cyclin B, putative 0.0117 0.0557 0.4659
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0022 0.004
Schistosoma mansoni amine GPCR 0.0298 0.1534 0.1744
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0062 0.0256 0.0291
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0024 0.0051 0.0057
Onchocerca volvulus 0.005 0.0191 0.1079
Brugia malayi G-protein coupled receptor 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0256 0.0291
Onchocerca volvulus 0.0298 0.1534 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0189 0.0188
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0028 0.0076 0.0086
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0256 0.0287
Brugia malayi Cytochrome P450 family protein 0.0057 0.0232 0.0232
Loa Loa (eye worm) cyclin domain-containing protein 0.0028 0.0076 0.0075
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0062 0.0256 0.0287
Loa Loa (eye worm) cyclin domain-containing protein 0.0028 0.0076 0.0075
Entamoeba histolytica cyclin, domain containing protein 0.0028 0.0076 0.0478
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0022 0.0025
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0022 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Brugia malayi G-protein coupled receptor 0.0298 0.1534 0.1534
Echinococcus multilocularis conserved hypothetical protein 0.1366 0.7312 0.8314
Trichomonas vaginalis cyclin D, putative 0.0117 0.0557 0.4659
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0298 0.1534 0.1534
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0298 0.1534 0.1744
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0199 0.1001 0.0998
Brugia malayi hypothetical protein 0.002 0.0029 0.0029
Echinococcus granulosus tachykinin peptides receptor 99D 0.0298 0.1534 0.1719
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0139 0.0158
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0298 0.1534 0.1534
Entamoeba histolytica cyclin, domain containing protein 0.0028 0.0076 0.0478
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0164 0.139
Brugia malayi clathrin adaptor complex small chain 0.0165 0.0813 0.0813
Brugia malayi hypothetical protein 0.0028 0.0076 0.0076
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Schistosoma mansoni axis inhibition protein axin 0.002 0.0029 0.0033
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0029 0.0029
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0029 0.0029
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0122 0.0122
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypoxia-induced factor 1 0.015 0.0733 0.0732
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Echinococcus multilocularis cyclin k 0.0028 0.0076 0.0086
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0115 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Schistosoma mansoni hypothetical protein 0.0298 0.1534 0.1744
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Schistosoma mansoni axis inhibition protein axin 0.002 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Trypanosoma brucei mitotic cyclin 0.0028 0.0076 0.0072
Brugia malayi hypothetical protein 0.005 0.0195 0.0195
Echinococcus granulosus Cyclin L1 0.0028 0.0076 0.0085
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0062 0.0256 0.0291
Onchocerca volvulus 0.0028 0.0076 0.0312
Trichomonas vaginalis cyclin B3, putative 0.0028 0.0076 0.0606
Trichomonas vaginalis cyclins, putative 0.0028 0.0076 0.0606
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0256 0.0291
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0024 0.0024
Echinococcus multilocularis 0.0018 0.0019 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0215
Echinococcus granulosus peptide allatostatin:somatostatin 0.0298 0.1534 0.1719
Echinococcus granulosus fmrfamide receptor 0.0298 0.1534 0.1719
Schistosoma mansoni amine GPCR 0.0298 0.1534 0.1744
Onchocerca volvulus 0.0062 0.0256 0.1511
Echinococcus granulosus neuropeptide Y receptor 0.0298 0.1534 0.1719
Trypanosoma brucei C-8 sterol isomerase, putative 0.1863 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0076 0.0606
Echinococcus multilocularis G-protein coupled receptor, putative 0.0298 0.1534 0.1744
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0298 0.1534 0.1719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0129 0.1055
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0298 0.1534 0.1534
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0029 0.0029
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0029 0.0033
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0062 0.0256 0.0287
Schistosoma mansoni hypothetical protein 0.0298 0.1534 0.1744
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.017 0.0194
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0415
Schistosoma mansoni neuropeptide receptor 0.0298 0.1534 0.1744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0417
Schistosoma mansoni nAChR subunit 0.0024 0.0051 0.0058
Trichomonas vaginalis clathrin coat assembly protein ap19, putative 0.0165 0.0813 0.6811
Echinococcus granulosus 7TM GPCR rhodopsin 0.0298 0.1534 0.1719
Echinococcus granulosus biogenic amine 5HT receptor 0.164 0.8795 0.9856
Toxoplasma gondii hypothetical protein 0.0089 0.0404 0.485
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0122 0.0122
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0115 0.0936
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0022 0.0019
Brugia malayi Pre-SET motif family protein 0.0206 0.1038 0.1038
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0022 0.0022
Echinococcus granulosus allatostatin A receptor 0.0298 0.1534 0.1719
Echinococcus granulosus dro:myosuppressin receptor 0.0298 0.1534 0.1719
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0116 0.0116
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0062 0.0256 0.0256
Giardia lamblia G2/mitotic-specific cyclin B 0.0199 0.1001 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Brugia malayi neuropeptide F receptor 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Brugia malayi CXXC zinc finger family protein 0.0057 0.0233 0.0233
Schistosoma mansoni biogenic amine (5HT) receptor 0.164 0.8795 1
Brugia malayi Melatonin receptor type 1A 0.0298 0.1534 0.1534
Leishmania major clathrin coat assembly protein AP17, putative 0.0165 0.0813 0.0809
Loa Loa (eye worm) cyclin C 0.0028 0.0076 0.0075
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0022 0.0019
Giardia lamblia Hypothetical protein 0.0117 0.0557 0.5203
Brugia malayi hypothetical protein 0.0162 0.0801 0.0801
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0256 0.0291
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0298 0.1534 0.1534
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0062 0.0256 0.0256
Echinococcus granulosus axis inhibition protein axin 0.002 0.0029 0.0033
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0298 0.1534 0.1534
Schistosoma mansoni cyclin G 0.0028 0.0076 0.0086
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0319 0.0357
Loa Loa (eye worm) G-protein coupled receptor 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0162 0.0801 0.08
Trichomonas vaginalis cyclin B3, putative 0.0028 0.0076 0.0606
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0062 0.0256 0.0256
Trichomonas vaginalis cyclin A, putative 0.0028 0.0076 0.0606
Echinococcus granulosus cyclin k 0.0028 0.0076 0.0085
Onchocerca volvulus 0.0298 0.1534 1
Schistosoma mansoni polycystin 1-related 0.002 0.0029 0.0033
Brugia malayi Serotonin receptor 0.0298 0.1534 0.1534
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Echinococcus granulosus tm gpcr rhodopsin 0.0298 0.1534 0.1719
Brugia malayi cytochrome P450 0.0018 0.0019 0.0019
Schistosoma mansoni alpha-1 adrenergic receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis cyclin G2 0.0028 0.0076 0.0086
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0121 0.0138
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0062 0.0256 0.0256
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0298 0.1534 0.1744
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0024 0.0051 0.0057
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0215
Echinococcus multilocularis serotonin receptor 0.164 0.8795 1
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0066 0.0063
Onchocerca volvulus 0.0298 0.1534 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0298 0.1534 0.1719
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0085 0.0683
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Brugia malayi hypothetical protein 0.0024 0.0051 0.0051
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0164 0.0161
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0164 0.139
Schistosoma mansoni adenoreceptor 0.0298 0.1534 0.1744
Echinococcus multilocularis neuropeptides capa receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0068 0.0067
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0029 0.0029
Schistosoma mansoni acetylcholine receptor subunit beta 0.0024 0.0051 0.0058
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0029 0.0081
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0029 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0067 0.0534
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0121 0.0136
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0108 0.0878
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0029 0.0033
Echinococcus granulosus neuropeptide receptor A26 0.0298 0.1534 0.1719
Echinococcus granulosus microtubule associated protein 2 0.071 0.3763 0.4217
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0088 0.0873
Echinococcus granulosus cyclin b3 0.0117 0.0557 0.0624
Onchocerca volvulus 0.0298 0.1534 1
Brugia malayi larval opioid receptor 0.0298 0.1534 0.1534
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0029 0.0033
Loa Loa (eye worm) cyclin domain-containing protein 0.0028 0.0076 0.0075
Plasmodium vivax AP-2 complex subunit sigma, putative 0.0165 0.0813 1
Trypanosoma cruzi CYC2-like cyclin, putative 0.0199 0.1001 0.0998
Onchocerca volvulus 0.0298 0.1534 1
Onchocerca volvulus 0.0038 0.0128 0.0661
Brugia malayi hypothetical protein 0.0121 0.0578 0.0578
Plasmodium vivax cyclin 4, putative 0.0028 0.0076 0.0676
Schistosoma mansoni neuropeptide F-like receptor 0.0298 0.1534 0.1744
Trichomonas vaginalis cyclins, putative 0.0199 0.1001 0.8396
Schistosoma mansoni lipoxygenase 0.0082 0.0366 0.0416
Onchocerca volvulus Protein CNPPD1 homolog 0.0028 0.0076 0.0312
Echinococcus multilocularis clathrin coat assembly protein ap17 0.0165 0.0813 0.0924
Echinococcus multilocularis cyclin B3 1 0.0117 0.0557 0.0633
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0029 0.0033
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0256 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0067 0.0534
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0088 0.0101
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.017 0.0194
Trichomonas vaginalis cyclin D, putative 0.0117 0.0557 0.4659
Brugia malayi Cyclin, N-terminal domain containing protein 0.0485 0.2546 0.2546
Echinococcus granulosus GPCR family 2 0.0037 0.0122 0.0136
Schistosoma mansoni hypothetical protein 0.0037 0.0122 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0164 0.1353
Schistosoma mansoni hypothetical protein 0.002 0.0029 0.0033
Brugia malayi putative neuropeptide receptor NPR1 0.0298 0.1534 0.1534
Schistosoma mansoni cyclins 0.0117 0.0557 0.0633
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0029 0.0032
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0019 0.0015
Echinococcus granulosus cyclins 0.0117 0.0557 0.0624
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0195 0.0191
Loa Loa (eye worm) cyclin domain-containing protein 0.0028 0.0076 0.0075
Loa Loa (eye worm) cyclin domain-containing protein 0.0028 0.0076 0.0075
Schistosoma mansoni hypothetical protein 0.0037 0.0122 0.0138
Loa Loa (eye worm) TYRA-2 protein 0.0298 0.1534 0.1534
Echinococcus granulosus cyclin y 0.0028 0.0076 0.0085
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0019 0.0015
Giardia lamblia Cyclin A 0.0117 0.0557 0.5203
Entamoeba histolytica clathrin adaptor complex small chain, putative 0.0165 0.0813 0.8062
Schistosoma mansoni neurotransmitter gated ion channel 0.0038 0.0128 0.0146
Schistosoma mansoni hypothetical protein 0.0037 0.0122 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0027 0.0068 0.0067
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0029 0.0032
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0298 0.1534 0.1534
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0045 0.005
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0256 0.0291
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0088 0.0101
Loa Loa (eye worm) melatonin receptor type 1A 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.1001 0.1001
Echinococcus multilocularis neuropeptide receptor 0.0298 0.1534 0.1744
Schistosoma mansoni amine GPCR 0.0953 0.5081 0.5777
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0256 0.0256
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0022 0.0025
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0122 0.0121
Brugia malayi Cyclin C 0.0028 0.0076 0.0076
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0062 0.0256 0.0287
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0038 0.0128 0.0146
Brugia malayi isocitrate dehydrogenase 0.0018 0.0022 0.0022
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0029 0.0033
Echinococcus multilocularis cyclin b3 0.0117 0.0557 0.0633
Schistosoma mansoni biogenic amine receptor 0.0298 0.1534 0.1744
Trichomonas vaginalis cyclins, putative 0.011 0.052 0.4343
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0029 0.0033
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0029 0.0029
Trichomonas vaginalis cyclin B, putative 0.0028 0.0076 0.0606
Onchocerca volvulus Putative nachr subunit 0.0062 0.0256 0.1511
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0298 0.1534 0.1744
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0029 0.0032
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0028
Brugia malayi hypothetical protein 0.0024 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Echinococcus granulosus cyclins 0.0028 0.0076 0.0085
Leishmania major cyclin 9, putative 0.0028 0.0076 0.0072
Leishmania major mitotic cyclin, putative 0.0028 0.0076 0.0072
Brugia malayi follicle stimulating hormone receptor 0.0527 0.2772 0.2772
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0115 0.0111
Loa Loa (eye worm) hypothetical protein 0.0028 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1863 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) CYL-1 protein 0.0028 0.0076 0.0075
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Schistosoma mansoni histamine h1 receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0028 0.0076 0.0086
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Echinococcus multilocularis cyclin t1 0.0028 0.0076 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Trypanosoma cruzi mitotic cyclin, putative 0.0028 0.0076 0.0072
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0298 0.1534 0.1719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0417
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0215
Brugia malayi G protein-coupled receptor F59B2.13 0.0298 0.1534 0.1534
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0102 0.105
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0298 0.1534 0.1744
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0029 0.0029
Onchocerca volvulus 0.0049 0.0189 0.1063
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0298 0.1534 0.1744
Schistosoma mansoni rab6-interacting 0.002 0.0029 0.0033
Echinococcus granulosus cyclin t1 0.0028 0.0076 0.0085
Trypanosoma cruzi cyclin 9, putative 0.0028 0.0076 0.0072
Echinococcus granulosus clathrin coat assembly protein ap17 0.0165 0.0813 0.0911
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0019 0.0015
Trypanosoma cruzi mitotic cyclin, putative 0.0028 0.0076 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Echinococcus granulosus hypothetical protein 0.1664 0.8924 1
Schistosoma mansoni nAChR subunit 0.0024 0.0051 0.0058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Leishmania major cytochrome p450-like protein 0.0027 0.0066 0.0063
Onchocerca volvulus 0.0298 0.1534 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0164 0.0161
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0256 0.0256
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.1239 0.1388
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) acetylcholine receptor protein 0.0024 0.0051 0.005
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis neuropeptide s receptor 0.0298 0.1534 0.1744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0068 0.0068
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0195 0.2181
Mycobacterium leprae putative cytochrome p450 0.0018 0.0019 0.5
Onchocerca volvulus 0.0298 0.1534 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0088 0.0101
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0298 0.1534 0.1744
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0037 0.0033
Brugia malayi hypothetical protein 0.002 0.0029 0.0029
Echinococcus granulosus lamin dm0 0.0027 0.0068 0.0076
Echinococcus granulosus somatostatin receptor 0.0298 0.1534 0.1719
Trichomonas vaginalis cyclin D, putative 0.0028 0.0076 0.0606
Echinococcus granulosus Ankyrin 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Brugia malayi PXA domain containing protein 0.002 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.008 0.0353 0.0401
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0029 0.0033
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0298 0.1534 0.1744
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0004 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.017 0.0191
Brugia malayi Cytochrome P450 family protein 0.0027 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0066 0.0522
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0164 0.0164
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0298 0.1534 0.1744
Brugia malayi hypothetical protein 0.0028 0.0076 0.0076
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0062 0.0256 0.0256
Echinococcus granulosus glycine receptor subunit beta 0.0062 0.0256 0.0287
Onchocerca volvulus 0.0298 0.1534 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0191 0.0191
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0019 0.5
Echinococcus granulosus g protein coupled receptor 0.0298 0.1534 0.1719
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Brugia malayi hypothetical protein 0.0024 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.1863 1 1
Echinococcus granulosus cyclin B 0.0199 0.1001 0.1122
Echinococcus multilocularis fmrfamide receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis musashi 0.0027 0.0068 0.0077
Loa Loa (eye worm) hypothetical protein 0.164 0.8795 0.8795
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Schistosoma mansoni loxhd1 0.002 0.0029 0.0033
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Echinococcus multilocularis g protein coupled receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.1239 0.1408
Onchocerca volvulus 0.0298 0.1534 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0164 0.0187
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0062 0.0256 0.0287
Trichomonas vaginalis cyclin A, putative 0.0199 0.1001 0.8396
Echinococcus multilocularis neuropeptide FF receptor 2 0.0298 0.1534 0.1744
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0088 0.0101
Leishmania major cytochrome p450-like protein 0.0018 0.0019 0.0015
Echinococcus multilocularis neuropeptide Y receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Entamoeba histolytica cyclin, putative 0.0117 0.0557 0.5432
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Brugia malayi hypothetical protein 0.002 0.0029 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.017 0.0194
Echinococcus multilocularis nAChR subunit 0.0038 0.0128 0.0146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.017 0.0191
Brugia malayi hypothetical protein 0.0032 0.0098 0.0098
Echinococcus granulosus cpg binding protein 0.0061 0.025 0.0281
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0024 0.0028
Schistosoma mansoni hypothetical protein 0.0298 0.1534 0.1744
Onchocerca volvulus 0.0298 0.1534 1
Brugia malayi neuropeptide F receptor 0.0298 0.1534 0.1534
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Schistosoma mansoni opsin-like receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0062 0.0256 0.0291
Echinococcus granulosus neuropeptide Y receptor 0.0298 0.1534 0.1719
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0024 0.0051 0.005
Echinococcus granulosus dnaJ subfamily B 0.0816 0.4338 0.4861
Echinococcus granulosus neuropeptide receptor 0.0298 0.1534 0.1719
Schistosoma mansoni lamin 0.0027 0.0068 0.0077
Echinococcus multilocularis serotonin receptor 0.164 0.8795 1
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0062 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Loa Loa (eye worm) neuropeptide F receptor 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0031 0.0088 0.0088
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0051 0.0051
Echinococcus multilocularis lamin dm0 0.0027 0.0068 0.0077
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Onchocerca volvulus 0.0027 0.0068 0.0259
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0004 0.0004
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0232 0.0231
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0128 0.0128
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Echinococcus granulosus nAChR subunit 0.0062 0.0256 0.0287
Schistosoma mansoni cyclin k 0.0028 0.0076 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0029 0.0033
Onchocerca volvulus 0.0057 0.0233 0.1355
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0029 0.0033
Brugia malayi latrophilin 2 splice variant baaae 0.008 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0243 0.1239 0.1238
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1191 1
Echinococcus multilocularis cpg binding protein 0.0061 0.025 0.0285
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0033
Echinococcus multilocularis dro:myosuppressin receptor 0.0298 0.1534 0.1744
Onchocerca volvulus 0.0199 0.1001 0.6459
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0233 0.0232
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0088 0.0101
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0066 0.0063
Schistosoma mansoni hypothetical protein 0.005 0.0191 0.0217
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0164 0.0161
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0028 0.0076 0.0676
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0116 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Echinococcus granulosus neuropeptides capa receptor 0.0298 0.1534 0.1719
Toxoplasma gondii hypothetical protein 0.0028 0.0076 0.0713
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0195 0.2213
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0195 0.2181
Schistosoma mansoni Cyclin fold protein 0.0028 0.0076 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0115 0.0936
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0417
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0076 0.0085
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0128 0.0128
Echinococcus multilocularis cyclin y 0.0028 0.0076 0.0086
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Echinococcus granulosus G1:S specific cyclin D1 0.0028 0.0076 0.0085
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0029 0.0029
Echinococcus granulosus intermediate filament protein 0.0027 0.0068 0.0076
Echinococcus multilocularis tumor protein p63 0.0336 0.1741 0.1979
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0116 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0298 0.1534 0.1744
Echinococcus granulosus alpha 1A adrenergic receptor 0.0298 0.1534 0.1719
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0062 0.0256 0.0291
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0062 0.0256 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Echinococcus multilocularis lamin 0.0027 0.0068 0.0077
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0062 0.0256 0.0256
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0062 0.0256 0.0291
Loa Loa (eye worm) LGC-31 protein 0.0062 0.0256 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0115 0.0936
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0028 0.0076 0.0086
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0062 0.0256 0.0256
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0029 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Brugia malayi AKH receptor 0.0298 0.1534 0.1534
Brugia malayi Doublecortin family protein 0.002 0.0029 0.0029
Schistosoma mansoni g1/s-specific cyclin C 0.0028 0.0076 0.0086
Echinococcus multilocularis sex peptide receptor 0.0298 0.1534 0.1744
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0022 0.0025
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0121 0.0121
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0586 0.0666
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) ACC-1 protein 0.0062 0.0256 0.0256
Onchocerca volvulus 0.0298 0.1534 1
Schistosoma mansoni microtubule-associated protein tau 0.071 0.3763 0.4279
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0068 0.0067
Brugia malayi Cation transporter family protein 0.0062 0.0256 0.0256
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0062 0.0256 0.0287
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0076 0.0072
Echinococcus multilocularis Ankyrin 0.0014 0.0001 0.0001
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0022 0.0022
Onchocerca volvulus 0.0062 0.0256 0.1511
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0006 0.0006
Loa Loa (eye worm) GABA receptor subunit 0.0038 0.0128 0.0128
Echinococcus granulosus cyclins 0.0117 0.0557 0.0624
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0066 0.0066
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0256 0.0256
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Schistosoma mansoni hypothetical protein 0.0816 0.4338 0.4933
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Echinococcus multilocularis g protein coupled receptor 0.0298 0.1534 0.1744
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0062 0.0256 0.0287
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0062 0.0256 0.0256
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Trichomonas vaginalis cyclin B3, putative 0.0117 0.0557 0.4659
Brugia malayi G protein-coupled receptor 0.0298 0.1534 0.1534
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0028 0.0076 0.0713
Brugia malayi Tachykinin-like peptides receptor 99D 0.0298 0.1534 0.1534
Echinococcus granulosus 7tm_1 domain containing protein 0.0298 0.1534 0.1719
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0004 0.0003
Leishmania major C-8 sterol isomerase-like protein 0.1863 1 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0028 0.0076 0.0075
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0022 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0115 0.0936
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.017 0.0194
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0045 0.0051
Brugia malayi hypothetical protein 0.002 0.0029 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Echinococcus granulosus expressed protein 0.0384 0.2 0.2241
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0215
Trypanosoma brucei cyclin 3 0.0028 0.0076 0.0072
Onchocerca volvulus 0.0235 0.1192 0.7729
Onchocerca volvulus Cyclin L homolog 0.0028 0.0076 0.0312
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0298 0.1534 0.1744
Schistosoma mansoni cpg binding protein 0.0061 0.025 0.0285
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Echinococcus multilocularis expressed protein 0.0384 0.2 0.2274
Echinococcus granulosus tumor protein p63 0.0336 0.1741 0.1951
Loa Loa (eye worm) RGS-3 protein 0.002 0.0029 0.0029
Onchocerca volvulus 0.0036 0.0116 0.0582
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0062 0.0256 0.0256
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Onchocerca volvulus 0.0024 0.0051 0.0146
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0298 0.1534 0.1744
Toxoplasma gondii cyclin dependent kinase binding protein 0.0028 0.0076 0.0713
Trypanosoma brucei cyclin 9 0.0028 0.0076 0.0072
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0038 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0029 0.0215
Entamoeba histolytica cyclin family protein 0.0117 0.0557 0.5432
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0164 0.0187
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0298 0.1534 0.1744
Echinococcus granulosus nAChR subunit 0.0038 0.0128 0.0144
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1038 0.1038
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0028
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0028 0.0076 0.0075
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0062 0.0256 0.0256
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0022 0.0025
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0029 0.0033
Onchocerca volvulus 0.0062 0.0256 0.1511
Echinococcus multilocularis cyclin B 0.0199 0.1001 0.1138
Brugia malayi ORL1-like opioid receptor 0.0298 0.1534 0.1534
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Trichomonas vaginalis cyclin B, putative 0.0028 0.0076 0.0606
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis g protein coupled receptor 0.0298 0.1534 0.1744
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0122 0.0136
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Loa Loa (eye worm) cyclin domain-containing protein 0.0485 0.2546 0.2546
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0029 0.0029
Trypanosoma brucei mitotic cyclin 6 0.0199 0.1001 0.0998
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0051 0.0058
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis neuropeptide Y receptor 0.0298 0.1534 0.1744
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0164 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0028 0.0076 0.0676
Toxoplasma gondii AP-2 complex subunit sigma-1, putative 0.0165 0.0813 1
Brugia malayi Dopamine receptor protein 1 0.071 0.3762 0.3762
Entamoeba histolytica cyclin, putative 0.0199 0.1001 1
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Brugia malayi hypoxia-induced factor 1 0.015 0.0733 0.0733
Brugia malayi hypothetical protein 0.0243 0.1239 0.1239
Trichomonas vaginalis cyclin B, putative 0.0199 0.1001 0.8396
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis nAChR subunit 0.0062 0.0256 0.0291
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0028 0.0076 0.0085
Echinococcus multilocularis GPCR, family 2 0.0037 0.0122 0.0138
Echinococcus granulosus cyclin 0.0028 0.0076 0.0085
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.0557 0.0624
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0298 0.1534 0.1719
Schistosoma mansoni opsin-like receptor 0.0298 0.1534 0.1744
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0029 0.0033
Schistosoma mansoni hypothetical protein 0.0023 0.0045 0.0051
Brugia malayi intermediate filament protein 0.0027 0.0068 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Trypanosoma cruzi cyclin 6, putative 0.0199 0.1001 0.0998
Echinococcus granulosus glycine receptor subunit beta 0.0062 0.0256 0.0287
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0952 0.5073 0.5073
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0298 0.1534 0.1744
Brugia malayi Dopamine receptor protein 2 0.0298 0.1534 0.1534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Echinococcus multilocularis neuropeptides capa receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Trichomonas vaginalis cyclins, putative 0.0199 0.1001 0.8396
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Echinococcus multilocularis cyclin 0.0028 0.0076 0.0086
Echinococcus granulosus serotonin receptor 0.0298 0.1534 0.1719
Loa Loa (eye worm) hypothetical protein 0.0199 0.1001 0.1001
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0298 0.1534 0.1534
Echinococcus granulosus cyclins 0.0117 0.0557 0.0624
Echinococcus granulosus neuropeptides capa receptor 0.0298 0.1534 0.1719
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0022 0.0019
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0033
Brugia malayi PAS domain containing protein 0.0048 0.0184 0.0184
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Trichomonas vaginalis cyclins, putative 0.0028 0.0076 0.0606
Brugia malayi Dopamine receptor 0.0298 0.1534 0.1534
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0116 0.0552 0.0552
Trichomonas vaginalis clathrin coat assembly protein ap17, putative 0.0165 0.0813 0.6811
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Schistosoma mansoni survival motor neuron protein 0.005 0.0191 0.0217
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.017 0.017
Echinococcus multilocularis dnaJ subfamily B 0.0816 0.4338 0.4933
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0062 0.0256 0.0291
Echinococcus multilocularis cyclin A3 4 0.0028 0.0076 0.0086
Trichomonas vaginalis cyclin B, putative 0.0199 0.1001 0.8396
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0006 0.0006
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Echinococcus multilocularis glycine receptor subunit beta 0.0062 0.0256 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0215
Schistosoma mansoni hypothetical protein 0.0028 0.0076 0.0086
Echinococcus multilocularis g-protein coupled receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0122 0.0138
Brugia malayi Cation transporter family protein 0.0062 0.0256 0.0256
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0029 0.0033
Brugia malayi excitatory GABA receptor EXP-1A 0.0062 0.0256 0.0256
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0029 0.0033
Schistosoma mansoni hypothetical protein 0.0018 0.0019 0.0022
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0062 0.0256 0.0291
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0022 0.0025
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0298 0.1534 0.1744
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0164 0.0161
Plasmodium falciparum AP-2 complex subunit sigma, putative 0.0165 0.0813 1
Onchocerca volvulus 0.0062 0.0256 0.1511
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Entamoeba histolytica cyclin family protein 0.0117 0.0557 0.5432
Schistosoma mansoni acetylcholine receptor-related 0.0024 0.0051 0.0058
Entamoeba histolytica hypothetical protein 0.0028 0.0076 0.0478
Loa Loa (eye worm) neuropeptide F receptor 0.0298 0.1534 0.1534
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0256 0.0287
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Onchocerca volvulus 0.0027 0.0068 0.0259
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0065
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0062 0.0256 0.0291
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0485 0.2546 0.2895
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0088 0.0101
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0076 0.0606
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0029 0.0033
Brugia malayi Calcitonin receptor-like protein seb-1 0.0116 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Schistosoma mansoni rab6-interacting 0.002 0.0029 0.0033
Echinococcus multilocularis orexin receptor type 2 0.0298 0.1534 0.1744
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Echinococcus multilocularis somatostatin receptor 0.0298 0.1534 0.1744
Brugia malayi GnHR receptor homolog 0.0298 0.1534 0.1534
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0019 0.0015
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0024 0.0051 0.0051
Echinococcus granulosus cyclin G2 0.0028 0.0076 0.0085

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 26.5 nM In vitro inhibitory activity against Factor Xa ChEMBL. 15225723

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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