Detailed information for compound 323348

Basic information

Technical information
  • TDR Targets ID: 323348
  • Name: N-[4-[(5-bromopyridin-2-yl)amino]-1,4-dioxo-1 -piperazin-1-ylbutan-2-yl]-4-(2-sulfamoylphen yl)benzamide
  • MW: 615.499 | Formula: C26H27BrN6O5S
  • H donors: 4 H acceptors: 6 LogP: 1.06 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(CC(C(=O)N1CCNCC1)NC(=O)c1ccc(cc1)c1ccccc1S(=O)(=O)N)Nc1ccc(cn1)Br
  • InChi: 1S/C26H27BrN6O5S/c27-19-9-10-23(30-16-19)32-24(34)15-21(26(36)33-13-11-29-12-14-33)31-25(35)18-7-5-17(6-8-18)20-3-1-2-4-22(20)39(28,37)38/h1-10,16,21,29H,11-15H2,(H,31,35)(H2,28,37,38)(H,30,32,34)
  • InChiKey: CSDFUNUUWSRLKF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-[(5-bromo-2-pyridyl)amino]-3-oxo-1-(piperazine-1-carbonyl)propyl]-4-(2-sulfamoylphenyl)benzamide
  • N-[3-[(5-bromo-2-pyridyl)amino]-3-oxo-1-[oxo(1-piperazinyl)methyl]propyl]-4-(2-sulfamoylphenyl)benzamide
  • N-[4-[(5-bromopyridin-2-yl)amino]-1,4-dioxo-1-piperazin-1-yl-butan-2-yl]-4-(2-sulfamoylphenyl)benzamide
  • N-[3-[(5-bromo-2-pyridyl)amino]-3-keto-1-(piperazine-1-carbonyl)propyl]-4-(2-sulfamoylphenyl)benzamide
  • N-[3-[(5-bromo-2-pyridyl)amino]-3-oxo-1-[oxo-(1-piperazinyl)methyl]propyl]-4-(2-sulfamoylphenyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypoxia-induced factor 1 0.015 0.0733 0.0732
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0298 0.1534 0.1534
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Echinococcus granulosus cyclin A3 4 0.0028 0.0076 0.0085
Brugia malayi G-protein coupled receptor 0.0298 0.1534 0.1534
Brugia malayi Dopamine receptor protein 2 0.0298 0.1534 0.1534
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.0557 0.0634
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0088 0.0099
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.1001 0.1001
Brugia malayi hypothetical protein 0.0162 0.0801 0.0801
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0022 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Onchocerca volvulus 0.0031 0.0088 0.0397
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0139 0.0158
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0256 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0065
Echinococcus multilocularis serotonin receptor 0.164 0.8795 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0115 0.0936
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0019 0.0015
Schistosoma mansoni intermediate filament proteins 0.0027 0.0068 0.0077
Echinococcus multilocularis cyclin y 0.0028 0.0076 0.0086
Echinococcus granulosus biogenic amine 5HT receptor 0.164 0.8795 0.9856
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Loa Loa (eye worm) cyclin domain-containing protein 0.0028 0.0076 0.0075
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0033
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0319 0.0357
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus granulosus sex peptide receptor 0.0298 0.1534 0.1719
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0586 0.0666
Echinococcus multilocularis G1:S specific cyclin D1 0.0028 0.0076 0.0086
Trypanosoma brucei mitotic cyclin 6 0.0199 0.1001 0.0998
Schistosoma mansoni polycystin 1-related 0.002 0.0029 0.0033
Echinococcus granulosus neuropeptide s receptor 0.0298 0.1534 0.1719
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0088 0.0873
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0029 0.0033
Echinococcus multilocularis clathrin coat assembly protein ap17 0.0165 0.0813 0.0924
Echinococcus multilocularis cyclin t1 0.0028 0.0076 0.0086
Plasmodium vivax SET domain protein, putative 0.0031 0.0088 0.0836
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0062 0.0256 0.0287
Brugia malayi putative neuropeptide receptor NPR1 0.0298 0.1534 0.1534
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Trypanosoma cruzi CYC2-like cyclin, putative 0.0199 0.1001 0.0998
Echinococcus multilocularis serotonin receptor 0.164 0.8795 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0088 0.0101
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0162 0.0801 0.08
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0122 0.0138
Trypanosoma cruzi cyclin 9, putative 0.0028 0.0076 0.0072
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0128 0.0146
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0062 0.0256 0.0287
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0066 0.0063
Schistosoma mansoni cyclin B3 0.0485 0.2546 0.2895
Loa Loa (eye worm) cyclin C 0.0028 0.0076 0.0075
Echinococcus granulosus alpha 1A adrenergic receptor 0.0298 0.1534 0.1719
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Schistosoma mansoni cyclin d 0.0028 0.0076 0.0086
Onchocerca volvulus 0.0062 0.0256 0.1511
Loa Loa (eye worm) hypothetical protein 0.008 0.0353 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0076 0.0606
Echinococcus granulosus Ankyrin 0.0014 0.0001 0.0001
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0033
Loa Loa (eye worm) cyclin domain-containing protein 0.0028 0.0076 0.0075
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0298 0.1534 0.1534
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0256 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0088 0.0101
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0024 0.0051 0.005
Brugia malayi Melatonin receptor type 1A 0.0298 0.1534 0.1534
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0195 0.0191
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0116 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.017 0.0194
Trichomonas vaginalis cyclin B, putative 0.0199 0.1001 0.8396
Echinococcus multilocularis sex peptide receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.0516 0.626
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0243 0.1239 0.1238
Schistosoma mansoni biogenic amine (5HT) receptor 0.0298 0.1534 0.1744
Echinococcus granulosus RUN 0.002 0.0029 0.0032
Schistosoma mansoni lipoxygenase 0.0082 0.0366 0.0416
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis somatostatin receptor 0.0298 0.1534 0.1744
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0215
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1038 0.1038
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0022 0.0025
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0062 0.0256 0.0256
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0022 0.0019
Echinococcus granulosus microtubule associated protein 2 0.071 0.3763 0.4217
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0029 0.0032
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0022 0.0019
Schistosoma mansoni biogenic amine receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis neuropeptide Y receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Echinococcus multilocularis RUN 0.002 0.0029 0.0033
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0122 0.0122
Leishmania major protein kinase, putative 0.0017 0.0017 0.0013
Brugia malayi sulfakinin receptor protein 0.0298 0.1534 0.1534
Trichomonas vaginalis cyclin D, putative 0.0117 0.0557 0.4659
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0164 0.0161
Schistosoma mansoni lamin 0.0027 0.0068 0.0077
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0195 0.2213
Echinococcus granulosus neuropeptides capa receptor 0.0298 0.1534 0.1719
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Trypanosoma cruzi cyclin 6, putative 0.0199 0.1001 0.0998
Echinococcus granulosus 7tm_1 domain containing protein 0.0298 0.1534 0.1719
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0028 0.0076 0.0086
Loa Loa (eye worm) CYL-1 protein 0.0028 0.0076 0.0075
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0232 0.0231
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0298 0.1534 0.1744
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0062 0.0256 0.0256
Schistosoma mansoni cpg binding protein 0.0057 0.0233 0.0265
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0028 0.0076 0.0072
Brugia malayi G protein-coupled receptor F59B2.13 0.0298 0.1534 0.1534
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0066 0.0063
Schistosoma mansoni neuropeptide receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Echinococcus granulosus cyclins 0.0117 0.0557 0.0624
Trypanosoma cruzi cyclin, putative 0.0199 0.1001 0.0998
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0116 1
Echinococcus multilocularis cyclin b3 0.0117 0.0557 0.0633
Loa Loa (eye worm) hypothetical protein 0.1863 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.017 0.017
Leishmania major C-8 sterol isomerase-like protein 0.1863 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0298 0.1534 0.1744
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0019 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Schistosoma mansoni Cyclin fold protein 0.0028 0.0076 0.0086
Schistosoma mansoni cyclin k 0.0028 0.0076 0.0086
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0062 0.0256 0.0256
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0029 0.0033
Onchocerca volvulus 0.0298 0.1534 1
Loa Loa (eye worm) GABA receptor subunit 0.0038 0.0128 0.0128
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0298 0.1534 0.1534
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0557 0.4659
Brugia malayi Cytochrome P450 family protein 0.0057 0.0232 0.0232
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0029 0.0033
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0022 0.0019
Brugia malayi Cyclin, N-terminal domain containing protein 0.0485 0.2546 0.2546
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Leishmania major cytochrome p450-like protein 0.0018 0.0019 0.0015
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0029 0.0033
Brugia malayi isocitrate dehydrogenase 0.0018 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Echinococcus granulosus Cyclin L1 0.0028 0.0076 0.0085
Leishmania major mitotic cyclin, putative 0.0028 0.0076 0.0072
Schistosoma mansoni microtubule-associated protein tau 0.071 0.3763 0.4279
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0122 0.0136
Schistosoma mansoni hypothetical protein 0.0298 0.1534 0.1744
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0184 0.021
Echinococcus granulosus fmrfamide receptor 0.0298 0.1534 0.1719
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0029 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0076 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Echinococcus granulosus cyclin y 0.0028 0.0076 0.0085
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0051 0.0058
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0298 0.1534 0.1534
Onchocerca volvulus 0.0298 0.1534 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0215
Echinococcus granulosus peptide allatostatin:somatostatin 0.0298 0.1534 0.1719
Schistosoma mansoni alpha-1 adrenergic receptor 0.0298 0.1534 0.1744
Toxoplasma gondii hypothetical protein 0.0028 0.0076 0.0713
Brugia malayi GnHR receptor homolog 0.0298 0.1534 0.1534
Onchocerca volvulus Cyclin L homolog 0.0028 0.0076 0.0312
Leishmania major cytochrome p450-like protein 0.0027 0.0066 0.0063
Echinococcus granulosus tm gpcr rhodopsin 0.0298 0.1534 0.1719
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0122 0.0122
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0029 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Loa Loa (eye worm) cytochrome P450 0.0018 0.0019 0.0019
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0256 0.0287
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.017 0.017
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0199 0.1001 0.1001
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Schistosoma mansoni histamine h1 receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Echinococcus multilocularis allatostatin A receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0298 0.1534 0.1534
Schistosoma mansoni neurotransmitter gated ion channel 0.0038 0.0128 0.0146
Schistosoma mansoni nAChR subunit 0.0024 0.0051 0.0058
Schistosoma mansoni amine GPCR 0.0298 0.1534 0.1744
Trichomonas vaginalis cyclin B, putative 0.0028 0.0076 0.0606
Echinococcus granulosus g protein coupled receptor 0.0298 0.1534 0.1719
Brugia malayi G-protein coupled receptor 0.0298 0.1534 0.1534
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0062 0.0256 0.0287
Schistosoma mansoni cyclin G2 0.0028 0.0076 0.0086
Entamoeba histolytica cyclin, domain containing protein 0.0028 0.0076 0.0478
Loa Loa (eye worm) hypothetical protein 0.0116 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0022 0.0022
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0029 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.017 0.0191
Onchocerca volvulus 0.0062 0.0256 0.1511
Schistosoma mansoni adenoreceptor 0.0298 0.1534 0.1744
Echinococcus multilocularis tumor protein p63 0.0336 0.1741 0.1979
Schistosoma mansoni amine GPCR 0.0953 0.5081 0.5777
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Schistosoma mansoni hypothetical protein 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Mycobacterium leprae putative cytochrome p450 0.0018 0.0019 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0121 0.0136
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0028 0.0076 0.0713
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0298 0.1534 0.1744
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0122 0.0138
Trichomonas vaginalis cyclin D, putative 0.0117 0.0557 0.4659
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0029 0.0033
Brugia malayi hypoxia-induced factor 1 0.015 0.0733 0.0733
Brugia malayi hypothetical protein 0.0024 0.0051 0.0051
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0298 0.1534 0.1719
Loa Loa (eye worm) cyclin domain-containing protein 0.0028 0.0076 0.0075
Brugia malayi PXA domain containing protein 0.002 0.0029 0.0029
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0062 0.0256 0.0291
Echinococcus multilocularis nAChR subunit 0.0062 0.0256 0.0291
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Loa Loa (eye worm) hypothetical protein 0.0031 0.0088 0.0088
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0024 0.0024
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0164 0.0161
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0022 0.0025
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0066 0.485
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0076 0.0606
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Echinococcus granulosus tumor protein p63 0.0336 0.1741 0.1951
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0085 0.0683
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Schistosoma mansoni single-minded 0.0048 0.0184 0.021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.017 0.0194
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0116 0.0552 0.0552
Onchocerca volvulus 0.0062 0.0256 0.1511
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0028 0.0076 0.0676
Echinococcus granulosus cyclin k 0.0028 0.0076 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0415
Echinococcus multilocularis g protein coupled receptor 0.0298 0.1534 0.1744
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Trichomonas vaginalis cyclins, putative 0.0199 0.1001 0.8396
Loa Loa (eye worm) neuropeptide F receptor 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Brugia malayi Cytochrome P450 family protein 0.0027 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0028 0.0076 0.0086
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Echinococcus multilocularis glycine receptor subunit beta 0.0062 0.0256 0.0291
Trypanosoma cruzi cyclin, putative 0.0199 0.1001 0.0998
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Leishmania major cyclin 9, putative 0.0028 0.0076 0.0072
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0298 0.1534 0.1744
Schistosoma mansoni acetylcholine receptor-related 0.0024 0.0051 0.0058
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0019 0.0015
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0024 0.0051 0.0057
Echinococcus granulosus cyclin t1 0.0028 0.0076 0.0085
Echinococcus multilocularis nAChR subunit 0.0038 0.0128 0.0146
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0029 0.0029
Schistosoma mansoni cyclin G 0.0028 0.0076 0.0086
Brugia malayi hypothetical protein 0.002 0.0029 0.0029
Brugia malayi hypothetical protein 0.0028 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Echinococcus granulosus allatostatin A receptor 0.0298 0.1534 0.1719
Loa Loa (eye worm) ACC-1 protein 0.0062 0.0256 0.0256
Echinococcus multilocularis neuropeptide s receptor 0.0298 0.1534 0.1744
Echinococcus granulosus somatostatin receptor 0.0298 0.1534 0.1719
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0076 0.0606
Schistosoma mansoni biogenic amine receptor 0.0298 0.1534 0.1744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0067 0.0534
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0033
Toxoplasma gondii AP-2 complex subunit sigma-1, putative 0.0165 0.0813 1
Echinococcus granulosus nAChR subunit 0.0062 0.0256 0.0287
Echinococcus granulosus G1:S specific cyclin D1 0.0028 0.0076 0.0085
Onchocerca volvulus 0.0298 0.1534 1
Onchocerca volvulus 0.0298 0.1534 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0256 0.0256
Onchocerca volvulus 0.0298 0.1534 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0164 0.139
Loa Loa (eye worm) doublecortin family protein 0.002 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0082 0.0366 0.0366
Brugia malayi excitatory GABA receptor EXP-1A 0.0062 0.0256 0.0256
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0233 0.0232
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0068 0.0067
Echinococcus granulosus single minded 2 0.0039 0.0135 0.0151
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0029 0.0029
Echinococcus granulosus neuropeptide receptor A26 0.0298 0.1534 0.1719
Plasmodium falciparum AP-2 complex subunit sigma, putative 0.0165 0.0813 1
Echinococcus granulosus neuropeptide receptor 0.0298 0.1534 0.1719
Onchocerca volvulus 0.0298 0.1534 1
Brugia malayi AKH receptor 0.0298 0.1534 0.1534
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0121 0.0121
Toxoplasma gondii cyclin dependent kinase binding protein 0.0028 0.0076 0.0713
Schistosoma mansoni loxhd1 0.002 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Giardia lamblia Hypothetical protein 0.0117 0.0557 0.5203
Trichomonas vaginalis cyclin B, putative 0.0117 0.0557 0.4659
Entamoeba histolytica cyclin family protein 0.0117 0.0557 0.5432
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0115 0.0111
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0004 0.0004
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0062 0.0256 0.0291
Schistosoma mansoni hypothetical protein 0.008 0.0353 0.0401
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0164 0.0184
Schistosoma mansoni neuropeptide receptor 0.0298 0.1534 0.1744
Echinococcus granulosus cyclins 0.0028 0.0076 0.0085
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0062 0.0256 0.0291
Echinococcus multilocularis G-protein coupled receptor, putative 0.0298 0.1534 0.1744
Echinococcus multilocularis microtubule associated protein 2 0.071 0.3763 0.4279
Trichomonas vaginalis clathrin coat assembly protein ap19, putative 0.0165 0.0813 0.6811
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Echinococcus granulosus axis inhibition protein axin 0.002 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0006 0.0006
Echinococcus granulosus serotonin receptor 0.0298 0.1534 0.1719
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0029 0.0033
Schistosoma mansoni opsin-like receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) cyclin domain-containing protein 0.0028 0.0076 0.0075
Schistosoma mansoni hypothetical protein 0.0037 0.0122 0.0138
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0068 0.0067
Echinococcus multilocularis fmrfamide receptor 0.0298 0.1534 0.1744
Schistosoma mansoni hypothetical protein 0.0298 0.1534 0.1744
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.164 0.8795 0.8795
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Schistosoma mansoni cytochrome P450 0.0018 0.0019 0.0022
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0037 0.0033
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0045 0.005
Echinococcus multilocularis cyclin 0.0028 0.0076 0.0086
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0062 0.0256 0.0291
Echinococcus granulosus dro:myosuppressin receptor 0.0298 0.1534 0.1719
Schistosoma mansoni hypothetical protein 0.0037 0.0122 0.0138
Trichomonas vaginalis cyclins, putative 0.0199 0.1001 0.8396
Loa Loa (eye worm) cyclin domain-containing protein 0.0485 0.2546 0.2546
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0298 0.1534 0.1719
Schistosoma mansoni hypothetical protein 0.0298 0.1534 0.1744
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0029 0.0032
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0066 0.0066
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0256 0.0256
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1863 1 1
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0029 0.0033
Onchocerca volvulus 0.0062 0.0256 0.1511
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0029 0.0033
Echinococcus multilocularis cyclin G2 0.0028 0.0076 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0298 0.1534 0.1744
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.1239 0.1408
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0298 0.1534 0.1744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.008 0.0639
Echinococcus multilocularis cyclin k 0.0028 0.0076 0.0086
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0024 0.0051 0.0057
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0062 0.0256 0.0287
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0215
Schistosoma mansoni hypothetical protein 0.0023 0.0045 0.0051
Echinococcus granulosus neuropeptide Y receptor 0.0298 0.1534 0.1719
Echinococcus granulosus cyclins 0.0117 0.0557 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0066 0.0522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0115 0.0936
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0102 0.105
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0028 0.0076 0.0075
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0191 0.0191
Loa Loa (eye worm) ACC-1 protein 0.0062 0.0256 0.0256
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0033
Trichomonas vaginalis cyclins, putative 0.0199 0.1001 0.8396
Trichomonas vaginalis cyclin B, putative 0.0028 0.0076 0.0606
Schistosoma mansoni amine GPCR 0.0298 0.1534 0.1744
Onchocerca volvulus 0.0057 0.0233 0.1355
Trichomonas vaginalis cyclins, putative 0.0028 0.0076 0.0606
Trypanosoma cruzi mitotic cyclin, putative 0.0028 0.0076 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Echinococcus granulosus tm gpcr rhodopsin 0.0298 0.1534 0.1719
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Schistosoma mansoni cpg binding protein 0.0061 0.025 0.0285
Onchocerca volvulus 0.0024 0.0051 0.0146
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0049 0.0189 0.0188
Schistosoma mansoni amine GPCR 0.0298 0.1534 0.1744
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0164 0.0161
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0195 0.2181
Trichomonas vaginalis clathrin coat assembly protein ap17, putative 0.0165 0.0813 0.6811
Brugia malayi Serotonin receptor 0.0298 0.1534 0.1534
Onchocerca volvulus 0.0298 0.1534 1
Echinococcus granulosus cyclin b3 0.0117 0.0557 0.0624
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0199 0.1001 0.0998
Onchocerca volvulus 0.0062 0.0256 0.1511
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0028
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0256 0.0287
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Onchocerca volvulus 0.0024 0.0051 0.0146
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0195 0.2181
Trichomonas vaginalis cyclin B3, putative 0.0117 0.0557 0.4659
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0298 0.1534 0.1719
Loa Loa (eye worm) hypothetical protein 0.0037 0.0122 0.0121
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0062 0.0256 0.0256
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0024 0.0051 0.005
Trypanosoma brucei cyclin 3 0.0028 0.0076 0.0072
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0115 0.0111
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Brugia malayi Pre-SET motif family protein 0.0206 0.1038 0.1038
Entamoeba histolytica cyclin family protein 0.0117 0.0557 0.5432
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0122 0.0136
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Onchocerca volvulus 0.0036 0.0116 0.0582
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0051 0.0051
Brugia malayi hypothetical protein 0.0121 0.0578 0.0578
Plasmodium vivax cyclin homologue, putative 0.0028 0.0076 0.0676
Brugia malayi hypothetical protein 0.002 0.0029 0.0029
Echinococcus granulosus cpg binding protein 0.0061 0.025 0.0281
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Echinococcus multilocularis cyclin B 0.0199 0.1001 0.1138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0115 0.0936
Schistosoma mansoni cyclins 0.0117 0.0557 0.0633
Trichomonas vaginalis cyclin B3, putative 0.0028 0.0076 0.0606
Toxoplasma gondii cyclin 4, putative 0.0028 0.0076 0.0713
Echinococcus granulosus cyclins 0.0117 0.0557 0.0624
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0038 0.0128 0.0128
Brugia malayi intermediate filament protein 0.0027 0.0068 0.0068
Entamoeba histolytica cyclin C, putative 0.0028 0.0076 0.0478
Onchocerca volvulus 0.0298 0.1534 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0298 0.1534 0.1534
Trichomonas vaginalis cyclins, putative 0.0028 0.0076 0.0606
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0062 0.0256 0.0256
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0139 0.0158
Leishmania major cytochrome p450-like protein 0.0018 0.0019 0.0015
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0116 0.0132
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0298 0.1534 0.1744
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0024 0.0051 0.0051
Echinococcus granulosus clathrin coat assembly protein ap17 0.0165 0.0813 0.0911
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0116 0.0116
Trypanosoma cruzi mitotic cyclin, putative 0.0028 0.0076 0.0072
Echinococcus multilocularis fmrfamide receptor 0.0298 0.1534 0.1744
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0051 0.0051
Onchocerca volvulus 0.0298 0.1534 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0298 0.1534 0.1719
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0038 0.0128 0.0146
Onchocerca volvulus 0.0038 0.0128 0.0661
Echinococcus granulosus dnaJ subfamily B 0.0816 0.4338 0.4861
Schistosoma mansoni clathrin coat assembly protein AP17 0.0165 0.0813 0.0924
Trypanosoma brucei cyclin 9 0.0028 0.0076 0.0072
Brugia malayi hypothetical protein 0.0032 0.0098 0.0098
Onchocerca volvulus 0.0298 0.1534 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0164 0.0187
Toxoplasma gondii hypothetical protein 0.0089 0.0404 0.485
Onchocerca volvulus 0.005 0.0191 0.1079
Loa Loa (eye worm) hypothetical protein 0.164 0.8795 0.8795
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0215
Schistosoma mansoni neuropeptide F-like receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Brugia malayi hypothetical protein 0.002 0.0029 0.0029
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0029 0.0081
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.1239 0.1388
Schistosoma mansoni opsin-like receptor 0.0298 0.1534 0.1744
Echinococcus granulosus G protein coupled receptor 139 0.0298 0.1534 0.1719
Giardia lamblia G2/mitotic-specific cyclin B 0.0199 0.1001 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0066 0.0066
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0032 0.0095 0.0095
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.017 0.0194
Onchocerca volvulus Cyclin L homolog 0.0028 0.0076 0.0312
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Loa Loa (eye worm) acetylcholine receptor protein 0.0024 0.0051 0.005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0006 0.0006
Schistosoma mansoni myosin xvIII 0.0298 0.1534 0.1744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0164 0.1353
Brugia malayi Dopamine receptor protein 1 0.071 0.3762 0.3762
Brugia malayi larval opioid receptor 0.0298 0.1534 0.1534
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0088 0.0101
Echinococcus granulosus intermediate filament protein 0.0027 0.0068 0.0076
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0062 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Echinococcus granulosus biogenic amine 5HT receptor 0.0298 0.1534 0.1719
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0062 0.0256 0.0287
Brugia malayi Cytochrome P450 family protein 0.0018 0.0019 0.0019
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0019 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Trypanosoma cruzi clathrin coat assembly protein AP17, putative 0.0165 0.0813 0.0809
Echinococcus granulosus GPCR family 2 0.0037 0.0122 0.0136
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.0557 0.0624
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0121 0.0138
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0122 0.0121
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Brugia malayi Cyclin C 0.0028 0.0076 0.0076
Entamoeba histolytica hypothetical protein 0.0038 0.0128 0.1018
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Schistosoma mansoni lamin 0.0027 0.0068 0.0077
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Brugia malayi Dopamine receptor 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0417
Onchocerca volvulus 0.0298 0.1534 1
Echinococcus multilocularis glycine receptor subunit beta 0.0062 0.0256 0.0291
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis g-protein coupled receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0006 0.0006
Echinococcus multilocularis dnaJ subfamily B 0.0816 0.4338 0.4933
Schistosoma mansoni hypothetical protein 0.0018 0.0019 0.0022
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0028 0.0076 0.0086
Trichomonas vaginalis cyclin B, putative 0.0199 0.1001 0.8396
Echinococcus granulosus lamin 0.0027 0.0068 0.0076
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0298 0.1534 0.1744
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0066 0.0522
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0088 0.0101
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0029 0.0029
Brugia malayi PAS domain containing protein 0.0048 0.0184 0.0184
Loa Loa (eye worm) cyclin domain-containing protein 0.0028 0.0076 0.0075
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0298 0.1534 0.1744
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0062 0.0256 0.0256
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0028 0.0076 0.0713
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0062 0.0256 0.0256
Schistosoma mansoni cyclin l 0.0028 0.0076 0.0086
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0028 0.0076 0.0075
Schistosoma mansoni cyclin B 0.0199 0.1001 0.1138
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Loa Loa (eye worm) clathrin adaptor complex small chain 0.0165 0.0813 0.0812
Echinococcus multilocularis cyclin y 0.0028 0.0076 0.0086
Echinococcus multilocularis G protein coupled receptor 139 0.0298 0.1534 0.1744
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0298 0.1534 0.1744
Echinococcus multilocularis conserved hypothetical protein 0.1366 0.7312 0.8314
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Leishmania major mitotic cyclin, putative 0.0028 0.0076 0.0072
Schistosoma mansoni nAChR subunit 0.0024 0.0051 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0067 0.0534
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0298 0.1534 0.1744
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0164 0.0187
Echinococcus granulosus orexin receptor type 2 0.0298 0.1534 0.1719
Schistosoma mansoni survival motor neuron protein 0.005 0.0191 0.0217
Onchocerca volvulus Neuropeptide F receptor homolog 0.0298 0.1534 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0062 0.0256 0.0287
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0298 0.1534 0.1744
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Onchocerca volvulus 0.0298 0.1534 1
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0062 0.0256 0.0291
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.017 0.0194
Schistosoma mansoni biogenic amine (5HT) receptor 0.164 0.8795 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.1001 0.1001
Loa Loa (eye worm) hypothetical protein 0.0315 0.1629 0.1629
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Brugia malayi PXA domain containing protein 0.002 0.0029 0.0029
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0298 0.1534 0.1719
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0319 0.0363
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Schistosoma mansoni hypothetical protein 0.0816 0.4338 0.4933
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.017 0.0194
Schistosoma mansoni opsin-like receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0029 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.017 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0417
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0029
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0022 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0256 0.0291
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0024 0.0051 0.0051
Brugia malayi CXXC zinc finger family protein 0.0057 0.0233 0.0233
Brugia malayi hypothetical protein 0.0243 0.1239 0.1239
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0121 0.0121
Onchocerca volvulus 0.0235 0.1192 0.7729
Schistosoma mansoni biogenic amine receptor 0.0298 0.1534 0.1744
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0066 0.0063
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0022 1
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0195 0.0191
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0062 0.0256 0.0256
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0029 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0415
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0088 0.0101
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0256 0.0256
Brugia malayi Doublecortin family protein 0.002 0.0029 0.0029
Onchocerca volvulus Protein CNPPD1 homolog 0.0028 0.0076 0.0312
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0115 0.0111
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0108 0.0878
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0029 0.0029
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0024 0.0051 0.0051
Echinococcus multilocularis dro:myosuppressin receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) cyclin domain-containing protein 0.0028 0.0076 0.0075
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0029 0.0033
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0029 0.0081
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0024 0.0051 0.0058
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0062 0.0256 0.0256
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0029 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0199 0.1001 0.1001
Brugia malayi cytochrome P450 0.0018 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0028
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0062 0.0256 0.0291
Giardia lamblia GTOR 0.0045 0.0164 0.0958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0129 0.1055
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0298 0.1534 0.1534
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Loa Loa (eye worm) melatonin receptor type 1A 0.0298 0.1534 0.1534
Brugia malayi Pre-SET motif family protein 0.0031 0.0088 0.0088
Onchocerca volvulus 0.0298 0.1534 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0019 0.0015
Schistosoma mansoni neuropeptide F-like receptor 0.0298 0.1534 0.1744
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0215
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0062 0.0256 0.0287
Echinococcus granulosus glycine receptor subunit beta 0.0062 0.0256 0.0287
Echinococcus multilocularis lamin dm0 0.0027 0.0068 0.0077
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0298 0.1534 0.1744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0102 0.0831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0038 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0028 0.0076 0.0075
Entamoeba histolytica cyclin, domain containing protein 0.0028 0.0076 0.0478
Echinococcus granulosus cyclin y 0.0028 0.0076 0.0085
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0004 0.0003
Brugia malayi Tachykinin-like peptides receptor 99D 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis rhodopsin orphan GPCR 0.0298 0.1534 0.1744
Giardia lamblia Cyclin A 0.0117 0.0557 0.5203
Echinococcus multilocularis g protein coupled receptor 0.0298 0.1534 0.1744
Brugia malayi hypothetical protein 0.0024 0.0051 0.0051
Leishmania major cyclin 0.0199 0.1001 0.0998
Echinococcus multilocularis GPCR, family 2 0.0037 0.0122 0.0138
Echinococcus granulosus neuropeptide receptor 0.0298 0.1534 0.1719
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0029 0.0033
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0298 0.1534 0.1534
Echinococcus multilocularis g protein coupled receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis cyclin B3 1 0.0117 0.0557 0.0633
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Loa Loa (eye worm) TYRA-2 protein 0.0298 0.1534 0.1534
Echinococcus multilocularis cyclin A3 4 0.0028 0.0076 0.0086
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0004 0.0004
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0164 0.0164
Trichomonas vaginalis cyclin B, putative 0.0199 0.1001 0.8396
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0029 0.0215
Echinococcus multilocularis neuropeptide receptor 0.0298 0.1534 0.1744
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0485 0.2546 0.2853
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Echinococcus granulosus cyclin B 0.0199 0.1001 0.1122
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0164 0.0161
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0029 0.0029
Echinococcus multilocularis neuropeptides capa receptor 0.0298 0.1534 0.1744
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0189 0.0215
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0076 0.0085
Echinococcus granulosus tm gpcr rhodopsin 0.0298 0.1534 0.1719
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0062 0.0256 0.0256
Echinococcus multilocularis neuropeptide receptor A26 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0022 0.004
Brugia malayi hypothetical protein 0.0024 0.0051 0.0051
Schistosoma mansoni axis inhibition protein axin 0.002 0.0029 0.0033
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Schistosoma mansoni hypothetical protein 0.0037 0.0122 0.0138
Echinococcus granulosus cyclin G2 0.0028 0.0076 0.0085
Onchocerca volvulus 0.0049 0.0189 0.1063
Trichomonas vaginalis cyclin B3, putative 0.0028 0.0076 0.0606
Brugia malayi neuropeptide F receptor 0.0298 0.1534 0.1534
Leishmania major hypothetical protein, conserved 0.005 0.0195 0.0191
Trichomonas vaginalis cyclins, putative 0.0117 0.0557 0.4659
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0045 0.0051
Entamoeba histolytica cyclin, putative 0.0117 0.0557 0.5432
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0108 0.0878
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0028 0.0076 0.0676
Schistosoma mansoni lipoxygenase 0.0117 0.0557 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0164 0.1353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0415
Echinococcus granulosus cyclin B3 1 0.0117 0.0557 0.0624
Onchocerca volvulus 0.0027 0.0068 0.0259
Trypanosoma brucei C-8 sterol isomerase, putative 0.1863 1 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0029 0.0033
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0256 0.0256
Echinococcus multilocularis lamin 0.0027 0.0068 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0164 0.1353
Brugia malayi neuropeptide F receptor 0.0298 0.1534 0.1534
Trichomonas vaginalis clathrin coat assembly protein ap19, putative 0.0165 0.0813 0.6811
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0164 0.0161
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0029 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0195 0.2181
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0029 0.0033
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0022 0.0025
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0028 0.0076 0.0676
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0298 0.1534 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0023 0.0019
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0164 0.0161
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0298 0.1534 0.1744
Onchocerca volvulus Putative nachr subunit 0.0062 0.0256 0.1511
Brugia malayi putative neuropeptide receptor 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0128
Onchocerca volvulus 0.0199 0.1001 0.6459
Echinococcus granulosus axis inhibition protein axin 0.002 0.0029 0.0033
Schistosoma mansoni neuropeptide f receptor 76f 0.0298 0.1534 0.1744
Echinococcus granulosus rhodopsin orphan GPCR 0.0298 0.1534 0.1719
Echinococcus multilocularis cyclin G2 0.0028 0.0076 0.0086
Plasmodium vivax AP-2 complex subunit sigma, putative 0.0165 0.0813 1
Echinococcus granulosus neuropeptide Y receptor 0.0298 0.1534 0.1719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0417
Trichomonas vaginalis cyclin B, putative 0.0199 0.1001 0.8396
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0256 0.0291
Brugia malayi ORL1-like opioid receptor 0.0298 0.1534 0.1534
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0256 0.0291
Loa Loa (eye worm) G-protein coupled receptor 0.0298 0.1534 0.1534
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0076 0.0676
Brugia malayi Cation transporter family protein 0.0062 0.0256 0.0256
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus granulosus g protein coupled receptor 0.0298 0.1534 0.1719
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0066 0.0066
Onchocerca volvulus 0.0027 0.0068 0.0259
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0029 0.0033
Plasmodium falciparum cyclin 0.0117 0.0557 0.6767
Brugia malayi Serotonin receptor 0.1208 0.646 0.646
Echinococcus multilocularis neuropeptide receptor 0.0298 0.1534 0.1744
Echinococcus granulosus lamin dm0 0.0027 0.0068 0.0076
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0062 0.0256 0.0256
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0128 0.0128
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0256 0.0256
Brugia malayi hypothetical protein 0.005 0.0195 0.0195
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0062 0.0256 0.0287
Echinococcus multilocularis cpg binding protein 0.0061 0.025 0.0285
Brugia malayi hypothetical protein 0.0298 0.1534 0.1534
Onchocerca volvulus 0.0028 0.0076 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0067 0.0534
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0051 0.0058
Echinococcus granulosus neuropeptides capa receptor 0.0298 0.1534 0.1719
Echinococcus multilocularis musashi 0.0027 0.0068 0.0077
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1191 1
Echinococcus multilocularis neuropeptides capa receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0022 0.0022
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0062 0.0256 0.0291
Echinococcus granulosus nAChR subunit 0.0038 0.0128 0.0144
Loa Loa (eye worm) hypothetical protein 0.0027 0.0068 0.0067
Brugia malayi hypothetical protein 0.002 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0298 0.1534 0.1744
Brugia malayi hypothetical protein 0.0028 0.0076 0.0076
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0022 0.0025
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0115 0.0936
Brugia malayi Cation transporter family protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0019 0.0021
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0256 0.0291
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0029 0.0029
Brugia malayi RE15519p 0.0298 0.1534 0.1534
Echinococcus granulosus cyclins 0.0117 0.0557 0.0624
Echinococcus granulosus cyclin 0.0028 0.0076 0.0085
Echinococcus granulosus neuropeptide FF receptor 2 0.0298 0.1534 0.1719
Trichomonas vaginalis cyclin A, putative 0.0199 0.1001 0.8396
Loa Loa (eye worm) LGC-31 protein 0.0062 0.0256 0.0256
Brugia malayi Cation transporter family protein 0.0062 0.0256 0.0256
Echinococcus granulosus cyclins 0.0117 0.0557 0.0624
Schistosoma mansoni neuropeptide receptor 0.0298 0.1534 0.1744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0115 0.0936
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0028 0.0076 0.0085
Brugia malayi follicle stimulating hormone receptor 0.0527 0.2772 0.2772
Trichomonas vaginalis cyclins, putative 0.011 0.052 0.4343
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Brugia malayi clathrin adaptor complex small chain 0.0165 0.0813 0.0813
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.071 0.3762 0.3761
Echinococcus granulosus g-protein coupled receptor 0.0298 0.1534 0.1719
Onchocerca volvulus 0.0298 0.1534 1
Loa Loa (eye worm) neuropeptide F receptor 0.0298 0.1534 0.1534
Trypanosoma brucei mitotic cyclin 0.0028 0.0076 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0298 0.1534 0.1744
Schistosoma mansoni hypothetical protein 0.0037 0.0122 0.0138
Echinococcus granulosus hypothetical protein 0.1664 0.8924 1
Onchocerca volvulus 0.0038 0.0128 0.0661
Schistosoma mansoni hypothetical protein 0.002 0.0029 0.0033
Echinococcus granulosus cyclin G2 0.0028 0.0076 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0029 0.0033
Trichomonas vaginalis cyclin A, putative 0.0028 0.0076 0.0606
Entamoeba histolytica clathrin adaptor complex small chain, putative 0.0165 0.0813 0.8062
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0298 0.1534 0.1744
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0062 0.0256 0.0291
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0062 0.0256 0.0256
Plasmodium vivax cyclin 4, putative 0.0028 0.0076 0.0676
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0298 0.1534 0.1744
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0527 0.2772 0.2771
Echinococcus multilocularis Ankyrin 0.0014 0.0001 0.0001
Echinococcus multilocularis neuropeptide FF receptor 2 0.0298 0.1534 0.1744
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0298 0.1534 0.1719
Loa Loa (eye worm) hypothetical protein 0.0952 0.5073 0.5073
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.005
Brugia malayi hypothetical protein 0.0024 0.0051 0.0051
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0062 0.0256 0.0256
Entamoeba histolytica cyclin, putative 0.0199 0.1001 1
Schistosoma mansoni amine GPCR 0.0298 0.1534 0.1744
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0164 0.139
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0024 0.0051 0.0058
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Echinococcus granulosus g protein coupled receptor 0.0298 0.1534 0.1719
Schistosoma mansoni acetylcholine receptor subunit beta 0.0024 0.0051 0.0058
Loa Loa (eye worm) G-protein coupled receptor 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Onchocerca volvulus 0.0024 0.0051 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0076 0.0072
Echinococcus multilocularis 0.0018 0.0019 0.0022
Giardia lamblia Sigma adaptin 0.0165 0.0813 0.7965
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0028 0.0076 0.0086
Schistosoma mansoni hypothetical protein 0.005 0.0191 0.0217
Leishmania major clathrin coat assembly protein AP17, putative 0.0165 0.0813 0.0809
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0029 0.0033
Schistosoma mansoni g1/s-specific cyclin C 0.0028 0.0076 0.0086
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Loa Loa (eye worm) hypothetical protein 0.0062 0.0256 0.0256
Onchocerca volvulus 0.0298 0.1534 1
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0028 0.0076 0.0085
Loa Loa (eye worm) RGS-3 protein 0.002 0.0029 0.0029
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0062 0.0256 0.0291
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0029 0.0033
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0022 0.0025
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0029 0.0033
Schistosoma mansoni neuropeptide receptor 0.0298 0.1534 0.1744
Echinococcus granulosus tachykinin peptides receptor 99D 0.0298 0.1534 0.1719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0417
Schistosoma mansoni rab6-interacting 0.002 0.0029 0.0033
Schistosoma mansoni regulator of G protein signaling 0.002 0.0029 0.0033
Echinococcus multilocularis neuropeptide Y receptor 0.0298 0.1534 0.1744
Brugia malayi cyclin fold protein 1 variant b 0.0028 0.0076 0.0076
Onchocerca volvulus 0.0298 0.1534 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0024 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0215
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0062 0.0256 0.0291
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0022 0.0025
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0062 0.0256 0.0256
Echinococcus granulosus expressed protein 0.0384 0.2 0.2241
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0022 0.0019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0298 0.1534 0.1744
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0485 0.2546 0.2895
Entamoeba histolytica hypothetical protein 0.0028 0.0076 0.0478
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0019 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0298 0.1534 0.1744
Onchocerca volvulus 0.0062 0.0256 0.1511
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0029 0.0033
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0062 0.0256 0.0256
Plasmodium falciparum cyclin 1 0.0028 0.0076 0.0676
Echinococcus granulosus glycine receptor subunit beta 0.0062 0.0256 0.0287
Brugia malayi hypothetical protein 0.0024 0.0051 0.0051
Schistosoma mansoni growth hormone secretagogue receptor 0.0298 0.1534 0.1744
Schistosoma mansoni axis inhibition protein axin 0.002 0.0029 0.0033
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0022 0.004
Trichomonas vaginalis cyclins, putative 0.0199 0.1001 0.8396
Brugia malayi G protein-coupled receptor 0.0298 0.1534 0.1534
Brugia malayi Cytochrome P450 family protein 0.0027 0.0066 0.0066
Schistosoma mansoni rab6-interacting 0.002 0.0029 0.0033
Echinococcus multilocularis expressed protein 0.0384 0.2 0.2274
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0024 0.0051 0.0058
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0028 0.0076 0.0086
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0256 0.0291
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Schistosoma mansoni nAChR subunit 0.0062 0.0256 0.0291
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0004 0.0004
Echinococcus multilocularis Cyclin L1 0.0028 0.0076 0.0086
Schistosoma mansoni cpg binding protein 0.0061 0.025 0.0285
Brugia malayi Calcitonin receptor-like protein seb-1 0.0116 0.0552 0.0552
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0195 0.0191
Echinococcus multilocularis cyclins 0.0117 0.0557 0.0633
Brugia malayi latrophilin 2 splice variant baaae 0.008 0.0353 0.0353
Onchocerca volvulus 0.0298 0.1534 1
Loa Loa (eye worm) hypothetical protein 0.0298 0.1534 0.1534
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0298 0.1534 0.1744
Echinococcus multilocularis orexin receptor type 2 0.0298 0.1534 0.1744
Echinococcus granulosus 7TM GPCR rhodopsin 0.0298 0.1534 0.1719
Brugia malayi Cyclin, N-terminal domain containing protein 0.0028 0.0076 0.0076
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0029 0.0033
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0068 0.0068
Trichomonas vaginalis cyclin D, putative 0.0028 0.0076 0.0606
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0088 0.0101

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 90.9 nM In vitro inhibitory activity against Factor Xa ChEMBL. 15225723

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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