Detailed information for compound 330493

Basic information

Technical information
  • TDR Targets ID: 330493
  • Name: 1-cyclopentyl-3-[4-[methyl-[2-[3-(methylsulfo nylmethyl)anilino]pyrimidin-4-yl]amino]phenyl ]urea
  • MW: 494.609 | Formula: C25H30N6O3S
  • H donors: 3 H acceptors: 5 LogP: 3.54 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)N(c1ccnc(n1)Nc1cccc(c1)CS(=O)(=O)C)C)NC1CCCC1
  • InChi: 1S/C25H30N6O3S/c1-31(22-12-10-20(11-13-22)29-25(32)28-19-7-3-4-8-19)23-14-15-26-24(30-23)27-21-9-5-6-18(16-21)17-35(2,33)34/h5-6,9-16,19H,3-4,7-8,17H2,1-2H3,(H,26,27,30)(H2,28,29,32)
  • InChiKey: RSSJHZLDWXRKKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-cyclopentyl-3-[4-[methyl-[2-[3-(methylsulfonylmethyl)anilino]-4-pyrimidinyl]amino]phenyl]urea
  • 1-cyclopentyl-3-[4-[methyl-[2-[[3-(methylsulfonylmethyl)phenyl]amino]pyrimidin-4-yl]amino]phenyl]urea
  • 1-cyclopentyl-3-[4-[[2-[3-(mesylmethyl)anilino]pyrimidin-4-yl]-methyl-amino]phenyl]urea
  • 1-cyclopentyl-3-[4-[methyl-[2-[[3-(methylsulfonylmethyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]urea
  • 1-cyclopentyl-3-[4-[[2-[[3-(mesylmethyl)phenyl]amino]pyrimidin-4-yl]-methyl-amino]phenyl]urea
  • urea deriv. 30

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0006 0.0026 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0061
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.009 0.2844
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0014 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0079 0.0355
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0006 0.0026 0.0116
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0106 0.0108
Loa Loa (eye worm) hypothetical protein 0.0041 0.0456 0.2042
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0075 0.0885 0.1047
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0009 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.009 0.0401
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0035 0.0158
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0011 0.009 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0041 0.0456 0.2042
Entamoeba histolytica hypothetical protein 0.0032 0.035 0.4785
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0079 0.0355
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0148 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.007 0.0694
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0011 0.009 0.009
Schistosoma mansoni thyroid hormone receptor 0.001 0.0079 0.0094
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0061
Schistosoma mansoni tyrosine kinase 0.0077 0.0904 0.107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0075 0.0885 0.3964
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.009 0.101
Echinococcus multilocularis discoidin domain containing receptor 2 0.0011 0.0092 0.0092
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0075 0.0885 0.0885
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0014 0.0061
Echinococcus multilocularis liprin alpha 2 0.0006 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0041 0.0456 0.2042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0075 0.0885 0.0885
Schistosoma mansoni fkbp-rapamycin associated protein 0.0032 0.035 0.0414
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0079 0.0355
Echinococcus granulosus roundabout 2 0.0018 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0075 0.0885 0.0885
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0011 0.009 0.0058
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0148 0.0663
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0079 0.0079
Schistosoma mansoni nuclear receptor 0.0005 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0138 0.062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0456 0.2042
Brugia malayi Cytochrome P450 family protein 0.0012 0.0106 0.0476
Echinococcus granulosus tyrosine protein kinase otk 0.0007 0.0035 0.0035
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0655 0.2933
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0061
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0057 0.0655 0.0775
Schistosoma mansoni septate junction protein 0.0007 0.0035 0.0042
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Loa Loa (eye worm) hypothetical protein 0.0009 0.0063 0.0281
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0011 0.009 0.009
Schistosoma mansoni cell adhesion molecule 0.0007 0.0035 0.0042
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0148 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.0355
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0057 0.0655 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.009 0.0401
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0011 0.009 0.2844
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0011 0.009 0.0106
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0148 0.0148
Entamoeba histolytica hypothetical protein 0.0011 0.009 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.035 0.5147
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0011 0.009 0.2844
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0079 0.0094
Entamoeba histolytica hypothetical protein 0.0011 0.009 0.034
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0005 0.0014 0.0014
Schistosoma mansoni tyrosine kinase 0.0077 0.0904 0.107
Brugia malayi hypothetical protein 0.0006 0.0026 0.0116
Onchocerca volvulus Tyrosine kinase homolog 0.0173 0.2084 1
Schistosoma mansoni titin 0.0007 0.0035 0.0042
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0106 0.0626
Brugia malayi excitatory GABA receptor EXP-1A 0.0075 0.0885 0.3964
Echinococcus granulosus defective proboscis extension response 0.0011 0.0093 0.0093
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0035 0.0158
Echinococcus multilocularis nAChR subunit 0.0075 0.0885 0.0885
Onchocerca volvulus 0.0006 0.0026 0.006
Brugia malayi nuclear receptor NHR-88 0.0005 0.0014 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0395 0.5864
Echinococcus multilocularis tyrosine protein kinase otk 0.0007 0.0035 0.0035
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0075 0.0885 0.0885
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0007 0.0035 0.0042
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.0355
Plasmodium vivax LCCL domain-containing protein 0.0011 0.0092 0.3198
Echinococcus multilocularis neuroglian 0.0014 0.0129 0.0129
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0011 0.0093 0.0093
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.009 0.0058
Echinococcus granulosus epidermal growth factor receptor 0.0147 0.177 0.177
Loa Loa (eye worm) hypothetical protein 0.0007 0.0035 0.0158
Onchocerca volvulus 0.0075 0.0885 0.4208
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0032 0.035 0.0414
Brugia malayi Cytochrome P450 family protein 0.0012 0.0106 0.0476
Echinococcus multilocularis roundabout 2 0.0007 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0061
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0011 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0036 0.0395 0.1768
Echinococcus granulosus peroxidasin 0.0007 0.0035 0.0035
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0011 0.009 0.009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.035 0.1566
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0815 1 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0049 0.0556 0.0556
Schistosoma mansoni tyrosine kinase 0.001 0.0076 0.009
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0035 0.0384 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0395 0.5864
Loa Loa (eye worm) hypothetical protein 0.0011 0.0092 0.0414
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0011 0.009 0.0058
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0057 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.0005 0.0021 0.0092
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0007 0.0035 0.0158
Echinococcus multilocularis nuclear receptor nhr 48 0.0005 0.0014 0.0014
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0079 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0079 0.0355
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0075 0.0885 0.3964
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0079 0.0079
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0057 0.0655 0.1609
Loa Loa (eye worm) TK/DDR protein kinase 0.0081 0.0955 0.428
Loa Loa (eye worm) phosphatidylinositol 3 0.0057 0.0655 0.2933
Brugia malayi hypothetical protein 0.0035 0.0384 0.172
Brugia malayi jmjC domain containing protein 0.0016 0.0148 0.0663
Loa Loa (eye worm) hypothetical protein 0.0041 0.0456 0.2042
Plasmodium falciparum LCCL domain-containing protein 0.0011 0.0092 0.3198
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0032 0.035 0.4785
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0679 0.0679
Loa Loa (eye worm) hypothetical protein 0.0081 0.0955 0.428
Loa Loa (eye worm) hypothetical protein 0.0011 0.009 0.0401
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0011 0.009 0.034
Schistosoma mansoni nAChR subunit 0.0035 0.0384 0.0454
Onchocerca volvulus 0.0075 0.0885 0.4208
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0061
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0007 0.0035 0.0035
Toxoplasma gondii PA14 domain-containing protein 0.0011 0.0092 0.1056
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0011 0.009 0.009
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0014 0.0061
Schistosoma mansoni nephrin 0.0014 0.0129 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.007 0.0694
Echinococcus granulosus contactin 0.0007 0.0035 0.0035
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0075 0.0885 0.3964
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0011 0.009 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.035 0.5147
Schistosoma mansoni tankyrase 0.0065 0.076 0.0899
Brugia malayi nuclear receptor NHR-88 0.001 0.0079 0.0355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Echinococcus multilocularis Immunoglobulin 0.0011 0.0093 0.0093
Echinococcus multilocularis tumor protein p63 0.0338 0.4113 0.4113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Brugia malayi ecdysteroid receptor 0.001 0.0079 0.0355
Onchocerca volvulus 0.0049 0.0564 0.2656
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0032 0.035 0.035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0079 0.0355
Schistosoma mansoni thyroid hormone receptor 0.001 0.0079 0.0094
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0011 0.009 0.0106
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0061
Schistosoma mansoni dock 0.0011 0.0092 0.0109
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0148 0.1939
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0011 0.009 0.101
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0057 0.0655 0.2933
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0035 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0079 0.0355
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0011 0.009 0.101
Loa Loa (eye worm) hypothetical protein 0.0011 0.0093 0.0418
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0011 0.009 0.0106
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0075 0.0885 0.0885
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0011 0.009 0.009
Leishmania major hypothetical protein, conserved 0.0296 0.3603 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0035 0.0158
Onchocerca volvulus Tankyrase homolog 0.0059 0.0676 0.3201
Echinococcus granulosus Sterile alpha motif SAM 0.0006 0.0026 0.0026
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0011 0.0092 0.0092
Schistosoma mansoni btb and poz domain-containing protein 0.0011 0.0092 0.0109
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0021 0.0092
Loa Loa (eye worm) hypothetical protein 0.0007 0.0035 0.0158
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0075 0.0885 0.0885
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Brugia malayi jmjC domain containing protein 0.0016 0.0148 0.0663
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0011 0.009 0.009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0079 0.0079
Toxoplasma gondii F5/8 type C domain-containing protein 0.0011 0.0092 0.1056
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0011 0.0092 0.1056
Echinococcus multilocularis hemicentin 1 0.0007 0.0035 0.0035
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0075 0.0885 0.1047
Schistosoma mansoni coup transcription factor 0.001 0.0079 0.0094
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0075 0.0885 0.3964
Onchocerca volvulus 0.0167 0.2008 0.9634
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0679 0.0803
Echinococcus multilocularis roundabout 2 0.0018 0.0174 0.0174
Schistosoma mansoni neurotransmitter gated ion channel 0.0041 0.0456 0.054
Plasmodium vivax LCCL domain-containing protein 0.0011 0.0092 0.3198
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.007 0.0694
Echinococcus granulosus nuclear receptor nhr 48 0.0005 0.0014 0.0014
Schistosoma mansoni sarm1 0.0006 0.0026 0.0031
Loa Loa (eye worm) hypothetical protein 0.0011 0.0093 0.0418
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0079 0.0079
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0011 0.0092 1
Entamoeba histolytica protein kinase rad3, putative 0.0032 0.035 0.4785
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0041 0.0456 0.2042
Brugia malayi WGR domain containing protein 0.0009 0.007 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.007 0.0694
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0148 0.0175
Trypanosoma cruzi hypothetical protein, conserved 0.0285 0.3468 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.009 0.0401
Brugia malayi hypothetical protein 0.0005 0.0014 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.035 0.5147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0011 0.009 0.101
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0079 0.0079
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0148 0.0148
Echinococcus granulosus twitchin 0.0014 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0032 0.035 0.1566
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0014 0.0061
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0035 0.0158
Brugia malayi Liprin-alpha 2 0.0006 0.0026 0.0116
Loa Loa (eye worm) hypothetical protein 0.0011 0.0092 0.0414
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0011 0.009 0.034
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0011 0.0093 0.011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.009 0.0401
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.009 0.0401
Brugia malayi hypothetical protein 0.0005 0.0014 0.0061
Echinococcus multilocularis epidermal growth factor receptor 0.0147 0.177 0.177
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0011 0.009 0.034
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0148 0.0175
Loa Loa (eye worm) hypothetical protein 0.0041 0.0456 0.2042
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0106 0.0476
Echinococcus multilocularis stromal interaction molecule 1 0.0006 0.0026 0.0026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0014 0.0014
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0025 0.026 0.026
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.009 0.101
Plasmodium falciparum LCCL domain-containing protein 0.0011 0.0092 0.3198
Echinococcus multilocularis discoidin domain containing receptor 2 0.0011 0.0092 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0007 0.0035 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0079 0.0355
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0011 0.009 0.101
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.008 0.0944 0.0944
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0011 0.009 0.009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0035 0.0158
Loa Loa (eye worm) hypothetical protein 0.0009 0.007 0.0312
Schistosoma mansoni nephrin 0.0007 0.0035 0.0042
Brugia malayi hypothetical protein 0.0005 0.0021 0.0092
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.009 0.0401
Echinococcus granulosus glycine receptor subunit beta 0.0075 0.0885 0.0885
Loa Loa (eye worm) hypothetical protein 0.0007 0.0035 0.0158
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0679 0.0803
Echinococcus granulosus roundabout 2 0.0007 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0079 0.0355
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0075 0.0885 0.3964
Leishmania major hypothetical protein, conserved 0.0016 0.0148 0.0166
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0215 0.3005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Echinococcus multilocularis Zinc finger, PHD finger 0.0011 0.009 0.009
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0011 0.009 0.2844
Schistosoma mansoni nAChR subunit 0.0075 0.0885 0.1047
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0148 0.0175
Echinococcus granulosus poly adp ribose polymerase 2 0.0009 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0075 0.0885 0.3964
Schistosoma mansoni hypothetical protein 0.0011 0.009 0.0106
Schistosoma mansoni zinc finger protein 0.0005 0.0014 0.0016
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0014 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Loa Loa (eye worm) hypothetical protein 0.0041 0.0456 0.2042
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0093 0.0418
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0014 0.0016
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0075 0.0885 0.3964
Loa Loa (eye worm) acetylcholine receptor protein 0.0035 0.0384 0.172
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0036 0.0395 0.5864
Schistosoma mansoni septate junction protein 0.0011 0.0092 0.0109
Loa Loa (eye worm) hypothetical protein 0.0007 0.0035 0.0158
Onchocerca volvulus 0.0035 0.0384 0.1789
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0041 0.0456 0.2042
Brugia malayi Cation transporter family protein 0.0075 0.0885 0.3964
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0057 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0035 0.0158
Entamoeba histolytica hypothetical protein 0.0011 0.009 0.034
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0215 0.0427
Trichomonas vaginalis hypothetical protein 0.0011 0.0092 0.1056
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Brugia malayi Prion-like- 0.0007 0.0035 0.0158
Schistosoma mansoni discoidin domain receptor 0.0011 0.0092 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.035 0.5147
Trypanosoma cruzi target of rapamycin kinase 3 0.0057 0.0655 0.1721
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Brugia malayi conserved hypotetical protein 0.0005 0.0014 0.0061
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0032 0.035 0.0824
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0079 0.0079
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0106 0.0476
Echinococcus multilocularis microtubule associated protein 2 0.0689 0.8447 0.8447
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0079 0.0355
Loa Loa (eye worm) ACC-1 protein 0.0075 0.0885 0.3964
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0075 0.0885 0.3964
Echinococcus granulosus glycine receptor subunit beta 0.0075 0.0885 0.0885
Schistosoma mansoni neuroglian 0.0007 0.0035 0.0042
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0075 0.0885 0.1047
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0075 0.0885 0.0885
Brugia malayi jmjC domain containing protein 0.0016 0.0148 0.0663
Toxoplasma gondii FATC domain-containing protein 0.0032 0.035 0.5147
Echinococcus multilocularis insulin receptor 0.0049 0.0556 0.0556
Brugia malayi hypothetical protein 0.0035 0.0384 0.172
Loa Loa (eye worm) TK/EGFR protein kinase 0.0147 0.177 0.7931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Brugia malayi hypothetical protein 0.0011 0.0093 0.0418
Loa Loa (eye worm) hypothetical protein 0.0011 0.0093 0.0418
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0035 0.0384 0.0384
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0006 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.009 0.0401
Schistosoma mansoni nAChR subunit 0.0075 0.0885 0.1047
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0148 0.023
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0106 0.0108
Loa Loa (eye worm) tnks protein 0.006 0.0688 0.3083
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0005 0.0014 0.0014
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0011 0.0092 0.1056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0079 0.0094
Onchocerca volvulus 0.001 0.0079 0.0317
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0041 0.0456 0.2042
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0075 0.0885 0.0885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0075 0.0885 0.3964
Onchocerca volvulus 0.0041 0.0456 0.2136
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.009 0.034
Echinococcus granulosus thyroid hormone receptor alpha 0.0005 0.0014 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Echinococcus multilocularis glycine receptor subunit beta 0.0075 0.0885 0.0885
Brugia malayi Neurabin protein 1 0.0006 0.0026 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Brugia malayi Peroxidasin 0.0007 0.0035 0.0158
Loa Loa (eye worm) hypothetical protein 0.0018 0.0174 0.0779
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.009 0.101
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Brugia malayi jmjC domain containing protein 0.0059 0.0679 0.304
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0011 0.009 0.034
Schistosoma mansoni tyrosine kinase 0.0147 0.177 0.2096
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0011 0.009 0.009
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0041 0.0456 0.2042
Schistosoma mansoni cell adhesion molecule 0.0015 0.0138 0.0164
Onchocerca volvulus 0.0006 0.0026 0.006
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0009 0.007 0.007
Giardia lamblia GTOR 0.0057 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0021 0.0092
Echinococcus granulosus discoidin domain receptor 0.0089 0.1052 0.1052
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0011 0.009 0.101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0049 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0007 0.0035 0.0158
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Loa Loa (eye worm) hypothetical protein 0.0006 0.0026 0.0116
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0075 0.0885 0.3964
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0075 0.0885 0.3964
Echinococcus granulosus epidermal growth factor receptor 0.008 0.0944 0.0944
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0011 0.009 0.034
Brugia malayi hypothetical protein 0.0035 0.0384 0.172
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Onchocerca volvulus 0.0075 0.0885 0.4208
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.0355
Onchocerca volvulus 0.0075 0.0885 0.4208
Brugia malayi nuclear receptor RXR 0.0005 0.0021 0.0092
Brugia malayi hypothetical protein 0.0035 0.0384 0.172
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.009 0.101
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0041 0.0456 0.054
Leishmania major cytochrome p450-like protein 0.0012 0.0106 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.035 0.5147
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0148 0.0148
Echinococcus granulosus roundabout 2 0.0007 0.0035 0.0035
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0011 0.009 0.101
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0035 0.0384 0.0384
Loa Loa (eye worm) TK/ROR protein kinase 0.0006 0.0031 0.0137
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0075 0.0885 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.035 0.5147
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0079 0.0355
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0009 0.007 0.007
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0011 0.009 0.0058
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0032 0.035 0.0824
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0035 0.0384 0.172
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0009 0.007 0.0082
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.009 0.0401
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0011 0.009 0.009
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0075 0.0885 0.3964
Echinococcus multilocularis liprin beta 1 0.0006 0.0026 0.0026
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0011 0.009 0.101
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0106 0.0476
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0079 0.0094
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0148 0.023
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0079 0.0355
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0007 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0079 0.0355
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0079 0.0355
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0011 0.0092 0.0092
Schistosoma mansoni vesicular amine transporter 0.0011 0.0093 0.011
Echinococcus granulosus Immunoglobulin 0.0011 0.0093 0.0093
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0006 0.0026 0.0031
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0057 0.0655 1
Echinococcus multilocularis SAM domain containing protein 0.0006 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.007 0.0694
Brugia malayi jmjC domain containing protein 0.0016 0.0148 0.0663
Echinococcus granulosus phd:f box containing protein 0.0016 0.0148 0.0148
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0679 0.0803
Loa Loa (eye worm) hypothetical protein 0.0006 0.0026 0.0116
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0075 0.0885 0.1047
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0075 0.0885 0.3964
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0041 0.0456 0.054
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0075 0.0885 0.3964
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0035 0.0384 0.172
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0079 0.0079
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0057 0.0655 0.1721
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.026 0.3722
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0011 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0006 0.0026 0.0031
Toxoplasma gondii F5/8 type C domain-containing protein 0.0011 0.0092 0.1056
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0079 0.0079
Echinococcus granulosus neuroglian 0.0007 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Brugia malayi tailless protein 0.0005 0.0014 0.0061
Echinococcus multilocularis epidermal growth factor receptor 0.008 0.0944 0.0944
Brugia malayi nuclear receptor RXR 0.0005 0.0014 0.0061
Schistosoma mansoni hypothetical protein 0.0025 0.026 0.0308
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.009 0.034
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0079 0.0355
Brugia malayi WGR domain containing protein 0.0009 0.007 0.0312
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.2232 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0026 0.0116
Loa Loa (eye worm) hypothetical protein 0.0025 0.026 0.1165
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0035 0.0384 0.172
Loa Loa (eye worm) ACC-1 protein 0.0075 0.0885 0.3964
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0079 0.0079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0021 0.0024
Brugia malayi nuclear receptor NHR-67 0.0005 0.0014 0.0061
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0011 0.009 0.0058
Schistosoma mansoni nAChR subunit 0.0075 0.0885 0.1047
Onchocerca volvulus 0.0075 0.0885 0.4208
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Loa Loa (eye worm) hypothetical protein 0.0006 0.0026 0.0116
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0057 0.0655 0.0655
Schistosoma mansoni nAChR subunit 0.0075 0.0885 0.1047
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Loa Loa (eye worm) hypothetical protein 0.0049 0.0563 0.252
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Onchocerca volvulus 0.0041 0.0456 0.2136
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Entamoeba histolytica hypothetical protein 0.0011 0.009 0.034
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0011 0.009 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0079 0.0355
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0011 0.009 0.0401
Schistosoma mansoni tyrosine kinase 0.008 0.0944 0.1118
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0057 0.0655 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0021 0.0092
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0075 0.0885 0.3964
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Schistosoma mansoni tyrosine kinase 0.0049 0.0556 0.0658
Loa Loa (eye worm) TK protein kinase 0.0006 0.0031 0.0137
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0057 0.0655 0.1721
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0011 0.009 0.0058
Echinococcus granulosus SAM domain containing protein 0.0006 0.0026 0.0026
Schistosoma mansoni nuclear receptor 0.0005 0.0014 0.0016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0035 0.0158
Loa Loa (eye worm) hypothetical protein 0.0011 0.0093 0.0418
Echinococcus multilocularis 0.0011 0.009 0.009
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0007 0.0035 0.0158
Echinococcus granulosus nAChR subunit 0.0041 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.0355
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0011 0.009 0.0058
Brugia malayi nuclear hormone receptor 0.0005 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0215 0.3005
Plasmodium vivax hypothetical protein 0.0011 0.009 0.2844
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0057 0.0655 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0035 0.0384 0.0454
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0564 0.0667
Echinococcus multilocularis 0.0045 0.0507 0.0507
Echinococcus granulosus discoidin domain containing receptor 2 0.0011 0.0092 0.0092
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0148 0.0148
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0075 0.0885 0.0885
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0079 0.0355
Brugia malayi Tnks protein 0.0065 0.0755 0.3382
Onchocerca volvulus 0.0011 0.009 0.0367
Toxoplasma gondii F5/8 type C domain-containing protein 0.0011 0.0092 0.1056
Echinococcus multilocularis hemicentin 1 0.0007 0.0035 0.0035
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0009 0.007 0.0082
Echinococcus multilocularis tankyrase 0.0065 0.0758 0.0758
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0006 0.0031 0.0031
Brugia malayi Immunoglobulin I-set domain containing protein 0.0006 0.0031 0.0137
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0035 0.0384 0.172
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.009 0.0401
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.009 0.034
Loa Loa (eye worm) phosphatidylinositol 3 0.0057 0.0655 0.2933
Brugia malayi Cation transporter family protein 0.0075 0.0885 0.3964
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0075 0.0885 0.0885
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0079 0.0079
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0075 0.0885 0.3964
Schistosoma mansoni lip-related protein (liprin) alpha 0.0006 0.0026 0.0031
Loa Loa (eye worm) LGC-31 protein 0.0075 0.0885 0.3964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.009 0.101
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0011 0.009 0.2844
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0079 0.0355
Schistosoma mansoni tyrosine kinase 0.008 0.0944 0.1118
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.0355
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0007 0.0035 0.0158
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0035 0.0384 0.172
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0079 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0035 0.0158
Brugia malayi jmjC domain containing protein 0.0059 0.0679 0.304
Echinococcus multilocularis nAChR subunit 0.0041 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0007 0.0035 0.0158
Schistosoma mansoni nAChR subunit 0.0075 0.0885 0.1047
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0148 0.0175
Echinococcus multilocularis roundabout 2 0.0007 0.0035 0.0035
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0011 0.009 0.101
Loa Loa (eye worm) hypothetical protein 0.0089 0.1052 0.4715
Onchocerca volvulus 0.0035 0.0384 0.1789
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0079 0.0317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Loa Loa (eye worm) DR-78 0.0005 0.0014 0.0061
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0075 0.0885 0.3964
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0007 0.0035 0.0042
Schistosoma mansoni acetylcholine receptor-related 0.0035 0.0384 0.0454
Schistosoma mansoni neurotransmitter gated ion channel 0.0035 0.0384 0.0454
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0011 0.009 0.101
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0079 0.0094
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0035 0.0384 0.172
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0075 0.0885 0.0885
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0014 0.0061
Schistosoma mansoni nuclear hormone receptor 0.001 0.0079 0.0094
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0057 0.0655 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0075 0.0885 0.1047
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0148 0.0663
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0679 0.0679
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0057 0.0655 1
Echinococcus granulosus tankyrase 0.0065 0.0758 0.0758
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0057 0.0655 0.1609
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Echinococcus granulosus glycine receptor subunit alpha 1 0.0075 0.0885 0.0885
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0011 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0061
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0011 0.009 0.0106
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.009 0.2844
Schistosoma mansoni microtubule-associated protein tau 0.0689 0.8447 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0148 0.0663
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0061
Loa Loa (eye worm) hypothetical protein 0.0005 0.0021 0.0092
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0079 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.009 0.101
Onchocerca volvulus 0.0011 0.009 0.0367
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0061
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0014 0.0016
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0011 0.0093 0.011
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0007 0.0035 0.0035
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0075 0.0885 0.3964
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0035 0.0384 0.0384
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0035 0.0384 0.172
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0079 0.0317
Onchocerca volvulus 0.0011 0.0092 0.0381
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0079 0.0355
Echinococcus granulosus microtubule associated protein 2 0.0689 0.8447 0.8447
Schistosoma mansoni acetylcholine receptor subunit beta 0.0035 0.0384 0.0454
Toxoplasma gondii target of rapamycin (TOR), putative 0.0057 0.0655 1
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0035 0.0384 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.007 0.0694
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0079 0.0094
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0057 0.0655 0.1721
Schistosoma mansoni nAChR subunit 0.0075 0.0885 0.1047
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0011 0.009 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.035 0.1566
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0014 0.0061
Echinococcus multilocularis serine protein kinase ATM 0.0032 0.035 0.035
Schistosoma mansoni hypothetical protein 0.0011 0.0092 0.0109
Loa Loa (eye worm) hypothetical protein 0.0041 0.0456 0.2042
Leishmania major phosphatidylinositol 3-kinase, putative 0.0057 0.0655 0.1609
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0148 0.0148
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0011 0.009 0.009
Loa Loa (eye worm) phosphatidylinositol kinase 0.0011 0.009 0.0401
Echinococcus granulosus liprin beta 1 0.0006 0.0026 0.0026
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0148 0.1939
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.035 0.5147
Schistosoma mansoni nAChR subunit 0.0035 0.0384 0.0454
Brugia malayi hypothetical protein 0.0035 0.0384 0.172
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0007 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Echinococcus granulosus discoidin domain containing receptor 2 0.0011 0.0092 0.0092
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0148 0.0148
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.001 0.0079 0.0355
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0014 0.0014
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0011 0.009 0.101
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Echinococcus multilocularis peroxidasin 0.0007 0.0035 0.0035
Echinococcus granulosus discoidin domain containing receptor 2 0.0011 0.0092 0.0092
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0075 0.0885 0.3964
Brugia malayi Protein kinase domain containing protein 0.0049 0.0556 0.2489
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0079 0.0094
Schistosoma mansoni nAChR subunit 0.0075 0.0885 0.1047
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0075 0.0885 0.3964
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0011 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0057 0.0655 0.0655
Schistosoma mansoni hypothetical protein 0.0006 0.0026 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0079 0.0094
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0057 0.0655 0.1721
Brugia malayi hypothetical protein 0.0006 0.0026 0.0116
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0075 0.0885 0.0885
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0057 0.0655 0.1609
Loa Loa (eye worm) hypothetical protein 0.0016 0.0148 0.0663
Onchocerca volvulus Putative nachr subunit 0.0075 0.0885 0.4208
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0032 0.035 0.4785
Echinococcus granulosus FTZ F1 alpha 0.001 0.0079 0.0079
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0185 0.2232 1
Brugia malayi steroid hormone receptor 0.001 0.0079 0.0355
Loa Loa (eye worm) hypothetical protein 0.0018 0.0174 0.0779
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0011 0.009 0.034
Loa Loa (eye worm) hypothetical protein 0.0005 0.0021 0.0092
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0006 0.0026 0.0116
Loa Loa (eye worm) GABA receptor subunit 0.0041 0.0456 0.2042
Brugia malayi Protein kinase domain containing protein 0.0092 0.1093 0.4896
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0009 0.007 0.0694
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0079 0.0355
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0148 0.0148
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.009 0.0401
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0075 0.0885 0.3964
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0093 0.0418
Schistosoma mansoni tyrosine kinase 0.0049 0.0556 0.0658
Plasmodium vivax JmjC domain containing protein 0.0016 0.0148 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0005 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0006 0.0026 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0215 0.0963
Brugia malayi Furin-like cysteine rich region family protein 0.0147 0.177 0.7931
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0679 0.304
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0011 0.009 0.101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Brugia malayi FAT domain containing protein 0.0025 0.026 0.1165
Echinococcus granulosus glycine receptor subunit alpha 1 0.0075 0.0885 0.0885
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0079 0.0355
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0057 0.0655 0.0775
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.009 0.034
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0014 0.0016
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0106 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0079 0.0355
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0079 0.0094
Entamoeba histolytica hypothetical protein 0.0041 0.0456 0.6602
Onchocerca volvulus 0.0092 0.1093 0.5213
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0011 0.009 0.101
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0057 0.0655 0.1609
Loa Loa (eye worm) hypothetical protein 0.0016 0.0148 0.0663
Echinococcus multilocularis Immunoglobulin 0.0011 0.0093 0.0093
Echinococcus granulosus hemicentin 1 0.0007 0.0035 0.0035
Echinococcus granulosus liprin alpha 2 0.0006 0.0026 0.0026
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0075 0.0885 0.0885
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0079 0.0355
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0014 0.0016
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0035 0.0384 0.172
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0075 0.0885 0.0885
Brugia malayi nuclear hormone receptor 0.001 0.0079 0.0355
Onchocerca volvulus 0.0035 0.0384 0.1789
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0079 0.0355
Echinococcus granulosus neuroglian 0.0014 0.0129 0.0129
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0021 0.0021
Brugia malayi ecdysone receptor 0.0005 0.0014 0.0061
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0007 0.0035 0.0158
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0011 0.009 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.007 0.0694
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0075 0.0885 0.0885
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0011 0.009 0.101
Echinococcus granulosus poly ADP ribose polymerase 1 0.0009 0.007 0.007
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0011 0.009 0.0106
Loa Loa (eye worm) hypothetical protein 0.0041 0.0456 0.2042
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0014 0.0014
Echinococcus multilocularis neuroglian 0.0007 0.0035 0.0035
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0011 0.009 0.034
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0057 0.0655 0.0655
Schistosoma mansoni roundabout 0.0007 0.0035 0.0042
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0148 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0079 0.0317
Brugia malayi coiled-coil like protein 1 0.0006 0.0026 0.0116
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0014 0.0014
Echinococcus granulosus glycine receptor subunit alpha 1 0.0075 0.0885 0.0885
Echinococcus granulosus stromal interaction molecule 1 0.0006 0.0026 0.0026
Schistosoma mansoni tyrosine kinase 0.0077 0.0904 0.107
Plasmodium vivax hypothetical protein, conserved 0.0011 0.009 0.2844
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0007 0.0035 0.0105
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0075 0.0885 0.0885
Onchocerca volvulus 0.0075 0.0885 0.4208
Loa Loa (eye worm) phosphatidylinositol 3 0.0011 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0035 0.0384 0.172
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0036 0.0395 0.5555
Echinococcus granulosus insulin receptor 0.0049 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Schistosoma mansoni hypothetical protein 0.0006 0.0026 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Echinococcus granulosus serine protein kinase ATM 0.0032 0.035 0.035
Echinococcus multilocularis glycine receptor subunit beta 0.0075 0.0885 0.0885
Echinococcus multilocularis lachesin 0.0007 0.0035 0.0035
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0021 0.0024
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0011 0.0092 0.1056
Brugia malayi Cation transporter family protein 0.0075 0.0885 0.3964
Loa Loa (eye worm) hypothetical protein 0.0049 0.0564 0.2525
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0075 0.0885 0.0885
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0011 0.009 0.101
Loa Loa (eye worm) hypothetical protein 0.0005 0.0021 0.0092
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0006 0.0026 0.0026
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0079 0.0094
Echinococcus granulosus tumor protein p63 0.0338 0.4113 0.4113
Echinococcus granulosus lachesin 0.0007 0.0035 0.0035
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0075 0.0885 0.0885
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0679 0.0679
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0035 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.007 0.0694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0006 0.0026 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0655 1
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0007 0.0035 0.0035
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0011 0.009 0.0058
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0148 0.0663
Schistosoma mansoni septate junction protein 0.0007 0.0035 0.0042
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0148 0.0175
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0079 0.0079
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0014 0.0014
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0011 0.009 0.034
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0025 0.026 0.026
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0092 0.1056
Schistosoma mansoni cell adhesion molecule 0.0007 0.0035 0.0042
Loa Loa (eye worm) hypothetical protein 0.0075 0.0885 0.3964
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0009 0.007 0.0312
Loa Loa (eye worm) TK/INSR protein kinase 0.0049 0.0556 0.2489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.035 0.5147
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0032 0.035 0.035
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0075 0.0885 0.3964
Echinococcus multilocularis discoidin domain containing receptor 2 0.0011 0.0092 0.0092
Brugia malayi Fibronectin type III domain containing protein 0.0011 0.0093 0.0418
Echinococcus granulosus nAChR subunit 0.0075 0.0885 0.0885
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0079 0.0355
Schistosoma mansoni cell adhesion molecule 0.0007 0.0035 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0093 0.0418
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0148 0.1337
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0021 0.0092
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0138 0.0138
Brugia malayi hypothetical protein 0.0005 0.0021 0.0092
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0021 0.0021
Echinococcus multilocularis discoidin domain receptor 0.0011 0.0092 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.007 0.0694
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0679 0.0679
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0011 0.0092 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0035 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.009 0.101
Schistosoma mansoni discoidin domain receptor 0.0011 0.0092 0.0109
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0011 0.009 0.2844

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1 nM Inhibitory concentration against human umbilical vein endothelial cells (HUVECs) induced by VEGF ChEMBL. 15990302
IC50 (functional) = 1 nM Inhibitory concentration against human umbilical vein endothelial cells (HUVECs) induced by VEGF ChEMBL. 15990302
IC50 (binding) = 31 nM Inhibitory concentration against human VEGFR2 kinase ChEMBL. 15990302
IC50 (binding) = 31 nM Inhibitory concentration against human VEGFR2 kinase ChEMBL. 15990302

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15990302

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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