Detailed information for compound 342277

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 198.196 | Formula: C8H6O4S
  • H donors: 2 H acceptors: 4 LogP: 1.42 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=O)/C=C(/c1cscc1)\O
  • InChi: 1S/C8H6O4S/c9-6(3-7(10)8(11)12)5-1-2-13-4-5/h1-4,9H,(H,11,12)/b6-3-
  • InChiKey: YWKAVKPASGNJCY-UTCJRWHESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Hepatitis C virus Hepatitis C virus NS5B RNA-dependent RNA polymerase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia Rrm3p helicase Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania infantum PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Candida albicans similar to putative DNA helicase involved in repair and recombination of mitochondrial DNA that also plays a role in (nuclear) c Get druggable targets OG5_128192 All targets in OG5_128192
Echinococcus granulosus ATP dependent DNA helicase PIF1 Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative Get druggable targets OG5_128192 All targets in OG5_128192
Echinococcus multilocularis ATP dependent DNA helicase PIF1 Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania braziliensis PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania infantum PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma congolense DNA repair and recombination helicase protein PIF6 Get druggable targets OG5_128192 All targets in OG5_128192
Entamoeba histolytica DNA repair and recombination protein, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania braziliensis PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Schistosoma mansoni hypothetical protein Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei gambiense DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania donovani PIF1 helicase-like protein, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania mexicana PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma congolense DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania mexicana PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Candida albicans similar to PIF1 DNA helicase Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania donovani PIF1 helicase-like protein, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 Get druggable targets OG5_128192 All targets in OG5_128192
Candida albicans DNA helicase Get druggable targets OG5_128192 All targets in OG5_128192
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128192 All targets in OG5_128192
Schistosoma japonicum ko:K01529 PIF1 5'-to-3' DNA helicase [EC:3.6.1.-], putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei gambiense DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta Get druggable targets OG5_128192 All targets in OG5_128192
Entamoeba histolytica hypothetical protein, conserved Get druggable targets OG5_128192 All targets in OG5_128192
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Kinase, PLK 0.0091 0.0111 0.038
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0001 0.001
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0021 0.0028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.0069 0.0226
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.002 0.0166
Brugia malayi MH1 domain containing protein 0.0014 0.0004 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0149 0.0521
Schistosoma mansoni hypothetical protein 0.0289 0.0382 0.3198
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0429 0.0575 1
Echinococcus granulosus lamin 0.0026 0.0021 0.0173
Brugia malayi MH2 domain containing protein 0.0025 0.002 0.0027
Mycobacterium ulcerans hypothetical protein 0.0023 0.0016 0.0189
Schistosoma mansoni hypothetical protein 0.0029 0.0024 0.0201
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0048 0.0404
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0111 0.011
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.004 0.141
Brugia malayi MH1 domain containing protein 0.0025 0.002 0.0027
Brugia malayi MH2 domain containing protein 0.0025 0.002 0.0027
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0025 0.0063
Entamoeba histolytica hypothetical protein 0.0078 0.0092 0.0571
Schistosoma mansoni helicase 0.0013 0.0002 0.0018
Schistosoma mansoni lamin 0.0026 0.0021 0.0173
Echinococcus granulosus smad 0.0025 0.002 0.0166
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0011 0.0011
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.002 0.0166
Giardia lamblia DINP protein human, muc B family 0.01 0.0122 0.0422
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0119 0.0149 0.3405
Echinococcus granulosus dnaJ subfamily B 0.088 0.1195 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0025 0.0386
Toxoplasma gondii hypothetical protein 0.01 0.0122 0.0424
Trichomonas vaginalis ap endonuclease, putative 0.004 0.004 0.0855
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0022 0.0016 0.005
Schistosoma mansoni hypothetical protein 0.0066 0.0076 0.0636
Schistosoma mansoni smad 0.0011 0 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0001 0.0001
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.007 0.0096
Plasmodium vivax exonuclease I, putative 0.0017 0.0008 0.002
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0011 0.0014
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0111 0.2503
Echinococcus granulosus muscleblind protein 0.0321 0.0427 0.3571
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0032 0.0089
Echinococcus multilocularis cpg binding protein 0.0105 0.0129 0.1081
Echinococcus multilocularis lamin dm0 0.0026 0.0021 0.0173
Toxoplasma gondii exonuclease III APE 0.004 0.004 0.0121
Schistosoma mansoni tar DNA-binding protein 0.0062 0.007 0.0585
Schistosoma mansoni smad1 5 8 and 0.0025 0.002 0.0166
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0019 0.0041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.0166 0.1393
Echinococcus granulosus tar DNA binding protein 0.0062 0.007 0.0585
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0017 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0046 0.0382
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0004 0.0063
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.004 0.0121
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0001 0.0014
Schistosoma mansoni hypothetical protein 0.0031 0.0027 0.0226
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0138
Giardia lamblia DNA damage repair protein 0.0029 0.0025 0.0063
Plasmodium vivax telomerase reverse transcriptase, putative 0.199 0.272 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0118 0.0147 0.2561
Loa Loa (eye worm) Smad1 0.0025 0.002 0.0337
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0017 0.0008 0.0063
Schistosoma mansoni DNA helicase recq5 0.0046 0.0048 0.0402
Echinococcus granulosus importin subunit beta 1 0.0034 0.0032 0.0265
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0138
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0021 0.0353
Schistosoma mansoni helicase 0.0145 0.0183 0.1536
Echinococcus multilocularis snurportin 1 0.0364 0.0486 0.4064
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0019 0.0161
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.0149 0.0521
Loa Loa (eye worm) helicase DNA-binding protein 0.0025 0.0019 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0001 0.0001
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0016 0.006
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.0246 0.2061
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.004 0.5
Echinococcus granulosus geminin 0.0201 0.0261 0.218
Schistosoma mansoni tar DNA-binding protein 0.0062 0.007 0.0585
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0118 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0001 0.0014
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0059 0.0189
Brugia malayi nuclear receptor NHR-88 0.0012 0.0001 0.0001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0016 0.5
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0016 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0001 0.0014
Entamoeba histolytica hypothetical protein 0.0028 0.0023 0.0104
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0011 0.0088
Onchocerca volvulus 0.0026 0.0021 0.002
Trypanosoma brucei chrX additional, unordered contigs 0.0029 0.0025 0.0063
Onchocerca volvulus 0.0046 0.0047 0.0047
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0081 0.0097 0.0329
Entamoeba histolytica deoxycytidyl transferase, putative 0.0093 0.0113 0.0717
Schistosoma mansoni tar DNA-binding protein 0.0062 0.007 0.0585
Leishmania major hypothetical protein, conserved 0.0025 0.0019 0.0041
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0093 0.0113 0.1965
Brugia malayi MH2 domain containing protein 0.0374 0.0498 0.0686
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.007 0.1211
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0016 0.006
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0 0.0004
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0047 0.0049 0.0408
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0019 0.0041
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0353
Schistosoma mansoni hypothetical protein 0.0364 0.0486 0.4064
Brugia malayi mbt repeat family protein 0.0046 0.0048 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0149 0.0521
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0025 0.0019 0.0161
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0016 0.0022
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0034 0.0031 0.0259
Loa Loa (eye worm) glutaminase 0.0324 0.043 0.7476
Echinococcus granulosus helicase 0.0013 0.0002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0046 0.0048 0.0834
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0081 0.0097 0.0329
Brugia malayi XPG I-region family protein 0.0017 0.0008 0.001
Echinococcus granulosus bloom syndrome protein 0.0084 0.0101 0.0841
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0019 0.0061
Brugia malayi N-terminal motif family protein 0.0175 0.0225 0.031
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0023 0.0016 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0082 0.0275
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0011 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0031 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0001 0.0001
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0034 0.0031 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0149 0.0521
Brugia malayi SNF2 family N-terminal domain containing protein 0.0013 0.0002 0.0003
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0007 0.0062
Giardia lamblia Telomerase catalytic subunit 0.199 0.272 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0032 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0111 0.0925
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0048 0.0066
Schistosoma mansoni hypothetical protein 0.0025 0.0019 0.0161
Onchocerca volvulus 0.0023 0.0016 0.0016
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0032 0.0265
Echinococcus granulosus neuropeptide receptor A26 0.0448 0.06 0.5025
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0082 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0122 0.0422
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0046 0.0063
Brugia malayi glutaminase DH11.1 0.0324 0.043 0.0591
Echinococcus multilocularis Protein lozenge 0.0054 0.0059 0.0492
Brugia malayi RNA, U transporter 1 0.0097 0.0118 0.0162
Echinococcus granulosus microtubule associated protein 2 0.0668 0.0904 0.7562
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0277
Toxoplasma gondii hypothetical protein 0.0058 0.0064 0.0208
Onchocerca volvulus 0.0429 0.0575 0.0574
Echinococcus multilocularis BRK domain 0.0025 0.0019 0.0161
Plasmodium falciparum exonuclease I, putative 0.0017 0.0008 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0019 0.0041
Toxoplasma gondii RNA-directed DNA polymerase 0.199 0.272 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.004 0.0697
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0357 0.0476 0.1727
Trypanosoma brucei DNA polymerase IV, putative 0.0113 0.014 0.0489
Brugia malayi polk-prov protein 0.0055 0.006 0.0083
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0011 0.0088
Echinococcus multilocularis smad 0.0025 0.002 0.0166
Brugia malayi Muscleblind-like protein 0.0321 0.0427 0.0587
Echinococcus multilocularis flap endonuclease 1 0.0081 0.0097 0.0811
Loa Loa (eye worm) hypothetical protein 0.0175 0.0225 0.3914
Trypanosoma brucei DNA polymerase eta, putative 0.0118 0.0147 0.0516
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0046 0.0048 0.0402
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0149 0.0521
Brugia malayi Bloom's syndrome protein homolog 0.0084 0.0101 0.0138
Echinococcus multilocularis flap endonuclease GEN 1 0.0017 0.0008 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.006 0.0195
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.0225 0.0225
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0093 0.0113 0.0948
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0026 0.0021 0.0049
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0008 0.0054
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.0904 0.7562
Echinococcus granulosus disco interacting protein 2 0.0047 0.0049 0.0408
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.004 0.0141
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0031 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0001 0.0014
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0057 0.0478
Echinococcus granulosus global transcription activator snf2l2 0.0145 0.0183 0.1536
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.0149 0.0521
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0001 0.0001
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0011 0.0144
Trypanosoma brucei polo-like protein kinase 0.0091 0.0111 0.038
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.002 0.0337
Entamoeba histolytica recQ family DNA helicase 0.0023 0.0017 0.0064
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.031 0.041 0.2735
Echinococcus granulosus flap endonuclease GEN 1 0.0017 0.0008 0.0063
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0054 0.0059 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0149 0.0521
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0014
Echinococcus multilocularis dna polymerase kappa 0.0119 0.0149 0.1247
Schistosoma mansoni hypothetical protein 0.088 0.1195 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0027 0.0037
Schistosoma mansoni DNA polymerase eta 0.0118 0.0147 0.1234
Schistosoma mansoni lozenge 0.0054 0.0059 0.0492
Loa Loa (eye worm) SNF2 family domain-containing protein 0.0013 0.0002 0.0029
Schistosoma mansoni hypothetical protein 0.0013 0.0002 0.0018
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0016 0.006
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0016 0.0189
Echinococcus granulosus cpg binding protein 0.0105 0.0129 0.1081
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0016 0.5
Schistosoma mansoni hypothetical protein 0.0201 0.0261 0.218
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0001 0.001
Plasmodium vivax importin-beta 2, putative 0.0034 0.0032 0.0109
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.002 0.0166
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0076 0.0104
Loa Loa (eye worm) MBCTL1 0.0053 0.0057 0.0987
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.006 0.0195
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.0904 0.7562
Schistosoma mansoni Smad4 0.0011 0 0.0004
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0035 0.0034 0.0096
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0111 0.0925
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0007 0.0062
Schistosoma mansoni phd finger protein 0.0013 0.0003 0.0024
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0001 0.001
Echinococcus granulosus flap endonuclease 1 0.0081 0.0097 0.0811
Echinococcus granulosus dna polymerase kappa 0.0119 0.0149 0.1247
Mycobacterium ulcerans DNA polymerase IV 0.0119 0.0149 0.3338
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0046 0.0382
Trypanosoma cruzi DNA polymerase eta, putative 0.0118 0.0147 0.0516
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0111 0.1918
Schistosoma mansoni importin beta-1 0.0034 0.0032 0.0265
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0048 0.0048
Brugia malayi intermediate filament protein 0.0026 0.0021 0.0028
Trichomonas vaginalis exonuclease%2C+putative 0.0017 0.0008 0.0083
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0011 0.0088
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1088 0.1481 1
Schistosoma mansoni exonuclease 0.0017 0.0008 0.0063
Mycobacterium tuberculosis Conserved hypothetical protein 0.0188 0.0244 1
Echinococcus granulosus peregrin 0.0013 0.0003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0429 0.0575 1
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0017 0.0008 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0001 0.0001
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0048 0.0404
Loa Loa (eye worm) hypothetical protein 0.0053 0.0057 0.0987
Plasmodium vivax DNA repair protein RAD2, putative 0.0017 0.0008 0.002
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0001 0.001
Schistosoma mansoni hypothetical protein 0.0078 0.0092 0.0767
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0008 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0111 0.2503
Mycobacterium ulcerans hypothetical protein 0.0188 0.0244 0.5585
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0016 0.0032
Brugia malayi BRM protein 0.0145 0.0183 0.0252
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0001 0.001
Schistosoma mansoni hypothetical protein 0.0201 0.0261 0.218
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0011 0.0088
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.004 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0008 0.0023
Loa Loa (eye worm) BRM protein 0.0075 0.0088 0.1517
Brugia malayi isocitrate dehydrogenase 0.0019 0.0011 0.0014
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.01 0.0122 0.0443
Mycobacterium ulcerans glutaminase 0.0324 0.043 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0019 0.0061
Loa Loa (eye worm) TAR-binding protein 0.0062 0.007 0.1211
Brugia malayi ecdysteroid receptor 0.0012 0.0001 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0016 0.0032
Entamoeba histolytica Flap nuclease, putative 0.0081 0.0097 0.0606
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0011 0.0175
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0027 0.0226
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0025 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0149 0.0521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0046 0.0382
Loa Loa (eye worm) hypothetical protein 0.0055 0.006 0.1044
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0149 0.0521
Echinococcus multilocularis tar DNA binding protein 0.0062 0.007 0.0585
Echinococcus multilocularis geminin 0.0201 0.0261 0.218
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0001 0.0001
Trichomonas vaginalis glutaminase, putative 0.0324 0.043 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0007 0.0062
Schistosoma mansoni kinase 0.0046 0.0049 0.0408
Trichomonas vaginalis flap endonuclease-1, putative 0.0017 0.0008 0.0083
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0034 0.0031 0.0086
Echinococcus granulosus snurportin 1 0.0364 0.0486 0.4064
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0076 0.009 0.0322
Leishmania major modification methylase-like protein 0.0023 0.0017 0.0035
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0054 0.0059 0.0208
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0025 0.0063
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.004 0.0338
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0118 0.0162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0001 0.001
Schistosoma mansoni smad 0.0025 0.002 0.0166
Trichomonas vaginalis DNA polymerase eta, putative 0.0119 0.0149 0.3405
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.0054 0.0171
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0025 0.0063
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0046 0.0048 0.083
Echinococcus granulosus dna polymerase eta 0.0118 0.0147 0.1234
Trichomonas vaginalis lymphoid specific helicase, putative 0.0026 0.0021 0.0398
Trichomonas vaginalis flap endonuclease-1, putative 0.0017 0.0008 0.0083
Echinococcus granulosus exonuclease 1 0.0017 0.0008 0.0063
Brugia malayi Smad1 0.0025 0.002 0.0027
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.0246 0.2061
Mycobacterium ulcerans DNA polymerase IV 0.0119 0.0149 0.3338
Schistosoma mansoni blooms syndrome DNA helicase 0.0061 0.0068 0.0572
Schistosoma mansoni hypothetical protein 0.0034 0.0031 0.0259
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0023 0.0017 0.0064
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.002 0.0166
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0001 0.001
Brugia malayi TAR-binding protein 0.0062 0.007 0.0096
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0111 0.0152
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0011 0.0011
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0016 0.0189
Plasmodium falciparum flap endonuclease 1 0.0081 0.0097 0.0349
Schistosoma mansoni lamin 0.0026 0.0021 0.0173
Plasmodium vivax DEAD/DEAH helicase, putative 0.0022 0.0016 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0046 0.0382
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0029
Brugia malayi hypothetical protein 0.0025 0.0019 0.0025
Schistosoma mansoni ap endonuclease 0.004 0.004 0.0338
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0111 0.2503
Brugia malayi ImpB/MucB/SamB family protein 0.0093 0.0113 0.0156
Entamoeba histolytica hypothetical protein 0.0078 0.0092 0.0571
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0023 0.0017 0.0035
Echinococcus multilocularis Chromo domain 0.0025 0.0019 0.0161
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0001 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.0149 0.0521
Trypanosoma brucei DNA polymerase IV, putative 0.0119 0.0149 0.0521
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0001 0.0001
Onchocerca volvulus 0.0026 0.0021 0.002
Loa Loa (eye worm) XPG I-region family protein 0.0017 0.0008 0.0124
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0111 0.038
Schistosoma mansoni intermediate filament proteins 0.0026 0.0021 0.0173
Loa Loa (eye worm) hypothetical protein 0.0161 0.0206 0.3584
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0001 0.001
Schistosoma mansoni hypothetical protein 0.0031 0.0027 0.0226
Plasmodium vivax DNA repair protein REV1, putative 0.0029 0.0025 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0025 0.0063
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0001 0.001
Brugia malayi MH1 domain containing protein 0.0014 0.0004 0.0005
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.002 0.0166
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.01 0.0122 0.4861
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0012 0.0001 0.0008
Schistosoma mansoni glutaminase 0.0324 0.043 0.3595
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0001 0.001
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0048 0.0404
Schistosoma mansoni terminal deoxycytidyl transferase 0.0093 0.0113 0.0948
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0048 0.0404
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0149 0.0521
Giardia lamblia DNA repair protein RAD52 0.1088 0.1481 0.543
Toxoplasma gondii DNA methyltransferase 2, putative 0.0023 0.0017 0.0035
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0054 0.0059 0.0189
Entamoeba histolytica DNA repair and recombination protein, putative 0.0034 0.0031 0.0159
Brugia malayi hypothetical protein 0.0429 0.0575 0.0791
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0027 0.0226
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0277
Brugia malayi Importin beta-1 subunit 0.0034 0.0032 0.0043
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0017 0.0035
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0016 0.0189
Mycobacterium tuberculosis Conserved hypothetical protein 0.0093 0.0113 0.4487
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0057 0.0478
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0111 0.0925
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0138
Plasmodium vivax flap endonuclease 1, putative 0.0081 0.0097 0.0349
Loa Loa (eye worm) hypothetical protein 0.0034 0.0032 0.0545
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0092 0.0767
Trichomonas vaginalis DNA helicase recq, putative 0.0084 0.0101 0.2267
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0048 0.0149
Loa Loa (eye worm) RNA binding protein 0.0062 0.007 0.1211
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0019 0.0161
Schistosoma mansoni flap endonuclease-1 0.0074 0.0086 0.072
Trichomonas vaginalis flap endonuclease-1, putative 0.0017 0.0008 0.0083
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0019 0.0161
Echinococcus multilocularis lamin 0.0026 0.0021 0.0173
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0013 0.0105
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0034 0.0031 0.0086
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0048 0.0066
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0048 0.0404
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0023 0.0442
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0048 0.0404
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0289
Schistosoma mansoni tar DNA-binding protein 0.0062 0.007 0.0585
Echinococcus granulosus Smad4 0.0025 0.002 0.0166
Echinococcus granulosus Helicase SANT associated DNA binding 0.0013 0.0002 0.0018
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0001 0.001
Schistosoma mansoni cpg binding protein 0.0101 0.0124 0.104
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0016 0.0032
Schistosoma mansoni ap endonuclease 0.004 0.004 0.0338
Brugia malayi MH1 domain containing protein 0.0025 0.002 0.0027
Echinococcus multilocularis muscleblind protein 1 0.0321 0.0427 0.3571
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0046 0.0382
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0046 0.0048 0.0402
Plasmodium falciparum DNA repair protein REV1, putative 0.0029 0.0025 0.0083
Echinococcus granulosus BRK domain containing protein 0.0025 0.0019 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0001 0.0014
Trichomonas vaginalis flap endonuclease-1, putative 0.0017 0.0008 0.0083
Plasmodium vivax helicase, putative 0.0013 0.0002 0.0000028749
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0027 0.0037
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0033 0.0031 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0001 0.0001
Echinococcus multilocularis bloom syndrome protein 0.0084 0.0101 0.0841
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0019 0.0041
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0017 0.0035
Leishmania major mitochondrial DNA polymerase beta 0.0357 0.0476 0.1727
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0138
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0011 0.0088
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0017 0.0008 0.0063
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0023 0.0017 0.0142
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0014
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0048 0.0834
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0034 0.0031 0.0086
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0029 0.0025 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0065
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0053 0.0057 0.0184
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0092 0.0767
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0007 0.0062
Echinococcus multilocularis neuropeptide receptor A26 0.0448 0.06 0.5025
Plasmodium falciparum importin beta, putative 0.0034 0.0032 0.0109
Schistosoma mansoni coup transcription factor 0.0012 0.0001 0.001
Brugia malayi RNA binding protein 0.0062 0.007 0.0096
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0001 0.001
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0001 0.001
Trypanosoma brucei unspecified product 0.0064 0.0073 0.0243
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0001 0.001
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0081 0.0097 0.0329
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0002 0.0018
Leishmania major DNA polymerase eta, putative 0.0118 0.0147 0.0516
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0023 0.0442
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0002 0.0018
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0017 0.0035
Brugia malayi steroid hormone receptor 0.0012 0.0001 0.0001
Echinococcus multilocularis GPCR, family 2 0.0031 0.0027 0.0226
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0034 0.0031 0.0259
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0016 0.0392
Echinococcus granulosus Chromo domain 0.0025 0.0019 0.0161
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0277
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0011 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0016 0.0022
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0011 0.0031
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0001 0.001
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0032 0.0089
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0023 0.0056
Brugia malayi nuclear hormone receptor 0.0012 0.0001 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.002 0.0337
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0001 0.0001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.004 0.0338
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0025 0.0063
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0001 0.001
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0048 0.0404
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0001 0.001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0027 0.0463
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0016 0.0189
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0011 0.0011
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.004 0.0121
Brugia malayi CXXC zinc finger family protein 0.0101 0.0124 0.0171
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0013 0.0105
Trichomonas vaginalis flap endonuclease-1, putative 0.0081 0.0097 0.2181
Schistosoma mansoni DNA polymerase IV / kappa 0.0029 0.0025 0.0206
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0001 0.001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0001 0.0001
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0023 0.0017 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0082 0.0275
Loa Loa (eye worm) hypothetical protein 0.0321 0.0427 0.7426
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0011 0.0011
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0017 0.0008 0.0063
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0011 0.0011
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0034 0.0031 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0047 0.1011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.0149 0.0521
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0118 0.2051
Trichomonas vaginalis DNA helicase recq1, putative 0.0084 0.0101 0.2267
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0019 0.0061
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.199 0.272 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0016 0.0189
Schistosoma mansoni Smad4 0.0011 0 0.0004
Schistosoma mansoni cpg binding protein 0.0105 0.0129 0.1081
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0019 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0001 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.004 0.0121
Loa Loa (eye worm) transcription factor SMAD2 0.0374 0.0498 0.8675
Loa Loa (eye worm) hypothetical protein 0.0321 0.0427 0.7426
Echinococcus multilocularis dna polymerase eta 0.0118 0.0147 0.1234
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0001 0.0001
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0025 0.0063
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0016 0.0189
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0007 0.0062
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0062 0.007 0.0585
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0046 0.0382
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0111 0.2503
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0001 0.0001
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0057 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0047 0.1011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0124
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0357 0.0476 0.1727
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0016 0.0022
Echinococcus multilocularis peregrin 0.0013 0.0003 0.0024
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0054 0.0171
Loa Loa (eye worm) hypothetical protein 0.0031 0.0027 0.0463
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0046 0.0048 0.0169
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.004 0.0223
Leishmania major DNA polymerase kappa, putative 0.01 0.0122 0.0422
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0022 0.0016 0.003
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0011 0.0011
Loa Loa (eye worm) RecQ helicase 0.0084 0.0101 0.1744
Loa Loa (eye worm) nuclear factor I 0.0014 0.0004 0.0065
Loa Loa (eye worm) CXXC zinc finger family protein 0.0101 0.0124 0.2157
Echinococcus granulosus intermediate filament protein 0.0026 0.0021 0.0173
Brugia malayi hypothetical protein 0.0078 0.0092 0.0126
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0054 0.0171
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.004 0.0055
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0124
Entamoeba histolytica recQ family helicase, putative 0.0054 0.0059 0.0349
Schistosoma mansoni smad1 5 8 and 0.0025 0.002 0.0166
Echinococcus granulosus lamin dm0 0.0026 0.0021 0.0173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0046 0.0382
Onchocerca volvulus 0.0101 0.0124 0.0124
Giardia lamblia Sgs1 DNA helicase, putative 0.0046 0.0048 0.0149
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0092 0.0767
Trichomonas vaginalis ap endonuclease, putative 0.004 0.004 0.0855
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0016 0.0392
Echinococcus granulosus neuropeptide s receptor 0.0448 0.06 0.5025
Brugia malayi hypothetical protein 0.0016 0.0007 0.0009
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0081 0.0097 0.0329
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0016 0.0189
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0034 0.0031 0.0086
Echinococcus multilocularis helicase 0.0013 0.0002 0.0018
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0001 0.0014
Schistosoma mansoni helicase 0.0013 0.0002 0.0018
Schistosoma mansoni smad1 5 8 and 0.0025 0.002 0.0166
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0364 0.0486 0.8452
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0001 0.001
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0111 0.038
Giardia lamblia Rrm3p helicase 0.0034 0.0031 0.0086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0001 0.001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0001 0.001
Echinococcus multilocularis musashi 0.0026 0.0021 0.0173
Trypanosoma brucei DNA polymerase IV, putative 0.0119 0.0149 0.0521
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0025 0.0063
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.004 0.0761
Trypanosoma brucei telomerase reverse transcriptase 0.199 0.272 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0014
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0169 0.0217 0.0773
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0011 0.0011
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0046 0.0048 0.0402
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0023 0.0442
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0054 0.0171
Entamoeba histolytica hypothetical protein 0.031 0.041 0.2735
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0023 0.0017 0.0142
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0021 0.0353
Loa Loa (eye worm) hypothetical protein 0.0046 0.0047 0.0819
Brugia malayi Associated with TFs and helicases family protein 0.0025 0.0019 0.0026
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0033 0.0031 0.0257
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0034 0.0031 0.0086
Giardia lamblia Flap structure-specific endonuclease 0.0081 0.0097 0.0329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0138
Loa Loa (eye worm) hypothetical protein 0.0025 0.0019 0.0318
Leishmania major telomerase reverse transcriptase, putative 0.199 0.272 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0001 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0001 0.001
Schistosoma mansoni SET domain protein 0.0033 0.0031 0.0257
Loa Loa (eye worm) hypothetical protein 0.0066 0.0076 0.1316
Loa Loa (eye worm) flap endonuclease-1 0.0081 0.0097 0.1679
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0057 0.0478
Entamoeba histolytica hypothetical protein 0.0078 0.0092 0.0571
Echinococcus multilocularis disco interacting protein 2 0.0047 0.0049 0.0408
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0027 0.0226
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0001 0.001
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0169 0.0217 0.0773
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0342
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0111 0.2503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0001 0.0014
Echinococcus granulosus GPCR family 2 0.0031 0.0027 0.0226
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.004 0.0121
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.01 0.0122 0.0422
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0014
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0057 0.0478
Plasmodium falciparum telomerase reverse transcriptase 0.199 0.272 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0111 0.2503
Onchocerca volvulus 0.0012 0.0001 0.0001
Echinococcus multilocularis exonuclease 1 0.0017 0.0008 0.0063
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0023 0.0017 0.0055
Schistosoma mansoni cpg binding protein 0.0105 0.0129 0.1081
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0357 0.0476 0.1727
Echinococcus multilocularis dnaJ subfamily B 0.088 0.1195 1
Echinococcus granulosus DNA methyltransferase 2, putative 0.0023 0.0017 0.0142
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0093 0.0113 0.0948
Loa Loa (eye worm) BRM protein 0.0092 0.0112 0.1938
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0054 0.0059 0.0189
Schistosoma mansoni Smad4 0.0025 0.002 0.0166
Leishmania major importin beta-1 subunit, putative 0.0028 0.0023 0.0056
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0046 0.0048 0.0402
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0001 0.001
Onchocerca volvulus 0.0046 0.0048 0.0048
Leishmania major DNA polymerase eta, putative 0.0054 0.0059 0.0189
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0057 0.0478
Brugia malayi Flap endonuclease-1 0.0081 0.0097 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0149 0.0521
Brugia malayi ImpB/MucB/SamB family protein 0.0118 0.0147 0.0203
Toxoplasma gondii histone lysine methyltransferase SET1 0.0122 0.0153 0.0534
Echinococcus multilocularis muscleblind protein 0.0321 0.0427 0.3571
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0001 0.0001
Trypanosoma brucei unspecified product 0.0113 0.014 0.0489
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0169 0.0217 0.0773
Loa Loa (eye worm) glutaminase 2 0.0324 0.043 0.7476
Brugia malayi mbt repeat family protein 0.0046 0.0048 0.0066
Trypanosoma brucei unspecified product 0.0064 0.0073 0.0243
Echinococcus multilocularis global transcription activator snf2l2 0.0145 0.0183 0.1536
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0008 0.0023
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.004 0.0141
Leishmania major DNA polymerase kappa, putative 0.0029 0.0025 0.0063
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0046 0.0788
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0054 0.0059 0.0189
Schistosoma mansoni SET domain protein 0.0015 0.0006 0.0048
Leishmania major DNA damage repair protein, putative 0.0029 0.0025 0.0063
Brugia malayi Disco-interacting protein 2 homolog 0.0046 0.0047 0.0065
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0004 0.0005
Echinococcus multilocularis Helicase SANT associated, DNA binding 0.0013 0.0002 0.0018
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0019 0.0161
Loa Loa (eye worm) hypothetical protein 0.0097 0.0118 0.2051
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0023 0.0017 0.0055
Loa Loa (eye worm) runx1 0.0054 0.0059 0.1016
Schistosoma mansoni hypothetical protein 0.0031 0.0027 0.0226
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0012 0.0017
Loa Loa (eye worm) MH2 domain-containing protein 0.0374 0.0498 0.8675
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0011 0.0031
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0093 0.0113 0.0948
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0001 0.001
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0012 0.0001 0.0008
Echinococcus multilocularis neuropeptide s receptor 0.0448 0.06 0.5025
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0001 0.001
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0111 0.038
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0048 0.0149
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0111 0.0699
Schistosoma mansoni hypothetical protein 0.0031 0.0027 0.0226
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0111 0.2503
Loa Loa (eye worm) hypothetical protein 0.0046 0.0048 0.083
Loa Loa (eye worm) histone methyltransferase 0.002 0.0013 0.0211
Echinococcus multilocularis Smad4 0.0025 0.002 0.0166
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0019 0.0161
Entamoeba histolytica hypothetical protein 0.0078 0.0092 0.0571
Onchocerca volvulus 0.0013 0.0002 0.0002
Schistosoma mansoni DNA helicase recq1 0.0046 0.0048 0.0402
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0018
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.004 0.0121
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.199 0.272 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0027 0.0226
Plasmodium falciparum DNA repair protein RAD2, putative 0.0017 0.0008 0.002
Brugia malayi Telomerase reverse transcriptase 0.5295 0.7264 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0001 0.001
Trichomonas vaginalis DNA helicase recq, putative 0.0054 0.0059 0.1289

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4 uM Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer) ChEMBL. 16190757
IC50 (binding) = 4 uM Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer) ChEMBL. 16190757

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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