Detailed information for compound 354266

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 446.073 | Formula: C12H12Cl4N6O4--
  • H donors: 4 H acceptors: 8 LogP: 3.64 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc(O)c(c(n1)N1CCN(CC1)c1nc(O)nc(c1Cl)O)Cl.[Cl-].[Cl-]
  • InChi: 1S/C12H12Cl2N6O4.2ClH/c13-5-7(15-11(23)17-9(5)21)19-1-2-20(4-3-19)8-6(14)10(22)18-12(24)16-8;;/h1-4H2,(H2,15,17,21,23)(H2,16,18,22,24);2*1H/p-2
  • InChiKey: TUHIAPQCWPLLFY-UHFFFAOYSA-L  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.024 0.2213
Leishmania major basic transcription factor 3a, putative 0.0038 0.0185 0.1673
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0012 0.0014 0.0109
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0236 0.0222
Echinococcus multilocularis inositol monophosphatase 1 0.0032 0.0141 0.0127
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0118 0.082
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.024 0.2213
Toxoplasma gondii aldehyde dehydrogenase 0.0049 0.0253 0.2959
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0853 0.8216
Brugia malayi jmjC domain containing protein 0.0034 0.0157 0.1226
Leishmania major DNA polymerase eta, putative 0.0089 0.0519 0.4944
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0148 0.0927
Echinococcus granulosus expressed protein 0.0033 0.0148 0.0135
Echinococcus granulosus dna polymerase eta 0.0168 0.1036 0.1023
Treponema pallidum NADH oxidase 0.0047 0.024 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0109 0.0852
Schistosoma mansoni glutamate synthase 0.0012 0.0014 0.0028
Echinococcus multilocularis expressed protein 0.0033 0.0148 0.0135
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0109 0.0095
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0931 0.6053 0.6048
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0012 0.0014 0.0000023137
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0012 0.0014 0.0000023137
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0047 0.024 0.2803
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1531 1 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0491 0.377
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0853 0.8216
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0174 0.016
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0014 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0253 0.0239
Plasmodium vivax glutathione reductase, putative 0.0135 0.082 1
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0185 0.2119
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.082
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0047 0.024 0.0226
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0047 0.024 0.2213
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0236 0.0222
Trichomonas vaginalis glutamate synthase, putative 0.0012 0.0014 0.0001
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0012 0.0014 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.024 0.2213
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0012 0.0014 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0492 0.4675
Schistosoma mansoni transcription factor btf3 0.0038 0.0185 0.0376
Plasmodium vivax thioredoxin reductase, putative 0.0135 0.082 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0012 0.0014 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0168 0.1036 0.8099
Trichomonas vaginalis DNA polymerase eta, putative 0.014 0.0853 0.5786
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0278 0.0264
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.024 0.2213
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0148 0.116
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0028 0.0119 0.0105
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0012 0.0014 0.0000023137
Leishmania major trypanothione reductase 0.0135 0.082 0.7893
Trypanosoma cruzi NADH dehydrogenase, putative 0.0012 0.0014 0.0001
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0012 0.0014 0.0002
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0014 0.0001
Schistosoma mansoni inositol monophosphatase 0.0032 0.0141 0.0286
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0185 0.2561
Trypanosoma cruzi DNA polymerase kappa, putative 0.014 0.0853 0.8216
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0165 0.187
Giardia lamblia PHD finger protein 15 0.0028 0.0118 0.1461
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0089 0.0519 0.6264
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0047 0.024 0.0226
Trypanosoma brucei DNA polymerase IV, putative 0.0134 0.0811 0.7798
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0143 0.1267
Trypanosoma brucei NADH dehydrogenase 0.0012 0.0014 0.0001
Toxoplasma gondii thioredoxin reductase 0.0135 0.082 1
Mycobacterium ulcerans thymidine phosphorylase 0.1531 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0114 0.0983
Echinococcus multilocularis dna polymerase eta 0.0168 0.1036 0.1023
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0157 0.0319
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0012 0.0014 0.0001
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0047 0.024 0.2803
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0125 0.0255
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0118 0.1287
Giardia lamblia DNA damage repair protein 0.0035 0.0165 0.2124
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0014 0.0001
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0014 0.0001
Plasmodium falciparum glutathione reductase 0.0047 0.024 0.2803
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0185 0.1673
Schistosoma mansoni DNA polymerase IV / kappa 0.0035 0.0165 0.0335
Onchocerca volvulus 0.0029 0.0125 0.0768
Onchocerca volvulus Alhambra homolog 0.0028 0.0118 0.0715
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0359 0.5176
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0085 0.0665
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0047 0.024 0.0488
Loa Loa (eye worm) hypothetical protein 0.0062 0.0337 0.2553
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0047 0.024 0.0226
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0278 0.0264
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0047 0.024 0.1877
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0143 0.1267
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0032 0.0141 0.19
Echinococcus multilocularis geminin 0.0381 0.2435 0.2425
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0359 0.0346
Echinococcus multilocularis glutamate synthase 0.0012 0.0014 0.0000023137
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0047 0.024 0.2803
Entamoeba histolytica hypothetical protein 0.0038 0.0185 0.2561
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0085 0.0491 0.377
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0047 0.024 0.2213
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0157 0.1129
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0032 0.0141 0.0874
Loa Loa (eye worm) hypothetical protein 0.0053 0.0278 0.2085
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0012 0.0014 0.0000023137
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0028 0.0119 0.038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0253 0.0239
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0047 0.024 0.0226
Schistosoma mansoni sulfide quinone reductase 0.0012 0.0014 0.0028
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.024 0.2213
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0143 0.1267
Mycobacterium ulcerans DNA polymerase IV 0.014 0.0853 0.0841
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.024 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0165 0.1477
Schistosoma mansoni rotamase 0.0033 0.0148 0.0302
Trypanosoma brucei trypanothione reductase 0.0135 0.082 0.7893
Brugia malayi beta-NAC-like protein 0.0038 0.0185 0.1445
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0014 0.0001
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0012 0.0014 0.0001
Schistosoma mansoni sulfide quinone reductase 0.0012 0.0014 0.0028
Trichomonas vaginalis glutathione reductase, putative 0.0047 0.024 0.1559
Trypanosoma cruzi DNA polymerase kappa, putative 0.014 0.0853 0.8216
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0315 0.2382
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0114 0.1245
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.024 0.2213
Schistosoma mansoni glutamate synthase 0.0012 0.0014 0.0028
Loa Loa (eye worm) hypothetical protein 0.0029 0.0125 0.0881
Leishmania major hypothetical protein, conserved 0.0012 0.0014 0.0001
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0278 0.2172
Schistosoma mansoni hypothetical protein 0.0027 0.0109 0.0222
Schistosoma mansoni hypothetical protein 0.028 0.1777 0.3614
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0143 0.1604
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0012 0.0014 0.0000023137
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0236 0.0222
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0053 0.0107
Brugia malayi latrophilin 2 splice variant baaae 0.0058 0.0314 0.2456
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0359 0.2731
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0342 0.2184 0.7863
Brugia malayi MH2 domain containing protein 0.0137 0.0833 0.6518
Echinococcus granulosus glutamate synthase 0.0012 0.0014 0.0000023137
Echinococcus multilocularis dna polymerase kappa 0.014 0.0853 0.0841
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0012 0.0014 0.0109
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0359 0.0346
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0165 0.1477
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0047 0.024 0.2803
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0012 0.0014 0.0001
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0012 0.0014 0.0000023137
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0012 0.0014 0.0000023137
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0853 0.8216
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0185 0.1351
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.054 0.0526
Mycobacterium ulcerans aldehyde dehydrogenase 0.0049 0.0253 0.0239
Schistosoma mansoni hypothetical protein 0.0058 0.0314 0.0639
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0114 0.0681 0.0668
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0012 0.0014 0.0001
Echinococcus multilocularis peregrin 0.0028 0.0118 0.0104
Mycobacterium tuberculosis Conserved hypothetical protein 0.0114 0.0681 0.0668
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.012 0.0724 0.695
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0125 0.0255
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.024 0.2213
Loa Loa (eye worm) hypothetical protein 0.0046 0.0236 0.1753
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0165 0.1477
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0185 0.2119
Plasmodium falciparum thioredoxin reductase 0.0135 0.082 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.014 0.0853 0.8216
Entamoeba histolytica thioredoxin reductase, putative 0.0012 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0168 0.1036 0.8078
Plasmodium vivax DNA repair protein REV1, putative 0.0035 0.0165 0.187
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0148 0.1063
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0118 0.1287
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0342 0.2184 0.2173
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0114 0.1245
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0278 0.0264
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0143 0.1267
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0141 0.1241
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0085 0.049
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0114 0.0983
Trichomonas vaginalis apoptosis inducing factor, putative 0.0012 0.0014 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.014 0.0853 0.0841
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0853 0.8216
Plasmodium vivax SET domain protein, putative 0.0029 0.0125 0.1382
Schistosoma mansoni DNA polymerase eta 0.0168 0.1036 0.2106
Trypanosoma brucei DNA polymerase kappa, putative 0.012 0.0724 0.695
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.024 0.2213
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0118 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0853 0.8216
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0174 0.016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0125 0.0255
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0236 0.1753
Trypanosoma cruzi DNA polymerase eta, putative 0.0089 0.0519 0.4944
Schistosoma mansoni aldehyde dehydrogenase 0.0049 0.0253 0.0514
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0236 0.0479
Trypanosoma brucei DNA polymerase IV, putative 0.014 0.0853 0.8216
Entamoeba histolytica disulphide oxidoreductase, putative 0.0012 0.0014 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0337 0.316
Leishmania major DNA polymerase kappa, putative 0.0035 0.0165 0.1477
Trichomonas vaginalis rotamase, putative 0.0032 0.0143 0.0892
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0125 0.0255
Trichomonas vaginalis glutamate synthase, putative 0.0012 0.0014 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0165 0.1477
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0125 0.0112
Leishmania major DNA damage repair protein, putative 0.0035 0.0165 0.1477
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.054 0.0526
Loa Loa (eye worm) MBCTL1 0.0053 0.0278 0.2085
Leishmania major hypothetical protein, conserved 0.0012 0.0014 0.0001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0049 0.0253 0.0239
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0047 0.024 1
Giardia lamblia DINP protein human, muc B family 0.012 0.0724 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0308 0.1958 0.1947
Trypanosoma brucei DNA damage repair protein, putative 0.0035 0.0165 0.1477
Echinococcus granulosus geminin 0.0381 0.2435 0.2425
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0135 0.082 0.0808
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0118 0.0104
Echinococcus granulosus dna polymerase kappa 0.014 0.0853 0.0841
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.1128 0.1116
Schistosoma mansoni inositol monophosphatase 0.0032 0.0141 0.0286
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0012 0.0014 0.0002
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0034 0.0158 0.1238
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0185 0.1178
Echinococcus multilocularis microtubule associated protein 2 0.0758 0.4917 0.491
Giardia lamblia NADH oxidase lateral transfer candidate 0.0047 0.024 0.3184
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0185 0.1673
Echinococcus granulosus GPCR family 2 0.0027 0.0109 0.0095
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.1128 0.1116
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0118 0.0104
Schistosoma mansoni hypothetical protein 0.0027 0.0109 0.0222
Trypanosoma brucei DNA polymerase eta, putative 0.0168 0.1036 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0125 0.0112
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0114 0.0983
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0012 0.0014 0.0000023137
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0085 0.0071
Echinococcus granulosus bloom syndrome protein 0.0023 0.0085 0.0071
Brugia malayi Bromodomain containing protein 0.0028 0.0118 0.0921
Trypanosoma cruzi DNA damage repair protein, putative 0.0035 0.0165 0.1477
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0034 0.0158 0.1238
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0432 0.2774 0.2764
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0014 0.0001
Echinococcus granulosus thioredoxin glutathione reductase 0.0136 0.0824 0.0811
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0012 0.0014 0.0002
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0114 0.1245
Schistosoma mansoni aldehyde dehydrogenase 0.0049 0.0253 0.0514
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0114 0.0681 0.0668
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0012 0.0014 0.0001
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0236 0.1528
Loa Loa (eye worm) hypothetical protein 0.0058 0.0314 0.2373
Schistosoma mansoni hypothetical protein 0.0381 0.2435 0.4953
Plasmodium falciparum phd finger protein, putative 0.0028 0.0118 0.1287
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0359 0.3381
Toxoplasma gondii NADPH-glutathione reductase 0.0047 0.024 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0492 0.4675
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0157 0.0143
Schistosoma mansoni glutamate synthase 0.0012 0.0014 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0114 0.0794
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0032 0.0141 0.0874
Trypanosoma brucei unspecified product 0.0079 0.0449 0.4257
Loa Loa (eye worm) hypothetical protein 0.0048 0.025 0.1868
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0047 0.024 0.2803
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0143 0.1939
Loa Loa (eye worm) RecQ helicase 0.0023 0.0085 0.0561
Echinococcus multilocularis thymidine phosphorylase 0.1531 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0027 0.0109 0.0751
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0012 0.0014 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0114 0.0681 0.5328
Loa Loa (eye worm) hypothetical protein 0.0117 0.0701 0.5431
Brugia malayi Thioredoxin reductase 0.0135 0.082 0.6415
Plasmodium falciparum glutathione reductase 0.0135 0.082 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0141 0.1241
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0157 0.0143
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0109 0.0852
Trichomonas vaginalis set domain proteins, putative 0.0233 0.1465 1
Leishmania major NADH dehydrogenase, putative 0.0012 0.0014 0.0001
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0359 0.281
Schistosoma mansoni hypothetical protein 0.0027 0.0109 0.0222
Brugia malayi Pre-SET motif family protein 0.0205 0.1279 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.014 0.0853 0.5786
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0141 0.1241
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0236 0.0222
Trypanosoma cruzi NADH dehydrogenase, putative 0.0012 0.0014 0.0001
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0012 0.0014 0.0000023137
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.012 0.0724 0.0711
Trypanosoma brucei DNA damage repair protein, putative 0.0035 0.0165 0.1477
Schistosoma mansoni microtubule-associated protein tau 0.0758 0.4917 1
Brugia malayi mbt repeat family protein 0.0046 0.0236 0.1843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0174 0.0353
Trichomonas vaginalis rotamase, putative 0.0033 0.0148 0.0927
Brugia malayi mbt repeat family protein 0.0046 0.0236 0.1843
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0278 0.0565
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0236 0.0479
Trypanosoma brucei DNA polymerase IV, putative 0.014 0.0853 0.8216
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0359 0.3381
Schistosoma mansoni disulfide oxidoreductase 0.0012 0.0014 0.0028
Loa Loa (eye worm) glutathione reductase 0.0135 0.082 0.6376
Trichomonas vaginalis mercuric reductase, putative 0.0047 0.024 0.1559
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.019 0.0177
Trypanosoma cruzi DNA polymerase kappa, putative 0.014 0.0853 0.8216
Schistosoma mansoni hypothetical protein 0.0027 0.0109 0.0222
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.0833 0.6479
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0014 0.0001
Mycobacterium tuberculosis Probable reductase 0.0308 0.1958 0.1947
Brugia malayi Calcitonin receptor-like protein seb-1 0.0085 0.0491 0.3838
Echinococcus granulosus jumonji domain containing protein 0.0039 0.019 0.0177
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.024 0.2213
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0114 0.1245
Trypanosoma cruzi DNA damage repair protein, putative 0.0035 0.0165 0.1477
Onchocerca volvulus 0.0233 0.1465 1
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2774 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0047 0.024 0.0226
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0032 0.0141 0.1572
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0174 0.016
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0047 0.024 0.2213
Trypanosoma brucei unspecified product 0.0134 0.0811 0.7798
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0308 0.1958 0.7044
Brugia malayi jmjC domain containing protein 0.0092 0.054 0.422
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0141 0.1241
Loa Loa (eye worm) hypothetical protein 0.0027 0.0109 0.0751
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0853 0.8216
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0853 0.8216
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0109 0.0095
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0012 0.0014 0.0109
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0012 0.0014 0.0001
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2774 0.2764
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0114 0.0681 0.1386
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0032 0.0141 0.5606
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0049 0.0253 0.0239
Loa Loa (eye worm) thioredoxin reductase 0.0135 0.082 0.6376
Mycobacterium ulcerans hypothetical protein 0.0035 0.0165 0.0151
Echinococcus granulosus microtubule associated protein 2 0.0758 0.4917 0.491
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0185 0.1178
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0012 0.0014 0.0000023137
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0032 0.0141 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0853 0.8216
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0342 0.2184 0.2173
Brugia malayi polk-prov protein 0.0062 0.0337 0.2634
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0359 0.3381
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0109 0.0095
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.024 0.2213
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0337 0.316
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0308 0.1958 0.1947
Trichomonas vaginalis inositol monophosphatase, putative 0.0032 0.0141 0.0874
Trypanosoma cruzi DNA polymerase eta, putative 0.0168 0.1036 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0136 0.0824 0.0811
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0012 0.0014 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0014 0.0001
Brugia malayi hypothetical protein 0.0018 0.005 0.039
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0042 0.0207 0.2399
Leishmania major DNA polymerase kappa, putative 0.012 0.0724 0.695
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0308 0.1958 0.1947
Echinococcus granulosus inositol monophosphatase 1 0.0032 0.0141 0.0127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0174 0.0353
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0174 0.0353
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0085 0.049
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0118 0.0239
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0012 0.0014 0.0002
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0012 0.0014 0.0000023137
Plasmodium falciparum DNA repair protein REV1, putative 0.0035 0.0165 0.187
Plasmodium falciparum thioredoxin reductase 0.0047 0.024 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.024 0.2213
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0853 0.8216
Onchocerca volvulus 0.0046 0.0236 0.1528
Leishmania major DNA polymerase eta, putative 0.0168 0.1036 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0037 0.0174 0.1262
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0109 0.0095
Leishmania major hypothetical protein, conserved 0.0028 0.0114 0.0983
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0036 0.0267
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0037 0.0174 0.1357
Brugia malayi glutathione reductase 0.0135 0.082 0.6415
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0066 0.0651
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.024 0.2213
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0174 0.016
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.024 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1279 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0125 0.1382
Brugia malayi hypothetical protein 0.0028 0.0114 0.0894
Loa Loa (eye worm) inositol-1 0.0032 0.0141 0.1002
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0308 0.1958 0.1947
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0012 0.0014 0.0001
Trypanosoma cruzi trypanothione reductase, putative 0.0135 0.082 0.7893
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0012 0.0014 0.0001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0114 0.0681 0.5277
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0492 0.4675
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0185 0.1178
Brugia malayi Pre-SET motif family protein 0.0029 0.0125 0.0981
Leishmania major hypothetical protein, conserved 0.0012 0.0014 0.0001
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0179 0.0166
Mycobacterium tuberculosis Probable oxidoreductase 0.0342 0.2184 0.2173
Schistosoma mansoni hypothetical protein 0.0012 0.0014 0.0028
Echinococcus multilocularis GPCR, family 2 0.0027 0.0109 0.0095
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0179 0.0166
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0012 0.0014 0.0000023137
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.0833 0.6479
Trypanosoma brucei chrX additional, unordered contigs 0.0035 0.0165 0.1477
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0049 0.0253 0.2336
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0185 0.1673
Schistosoma mansoni hypothetical protein 0.0028 0.0118 0.0239
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0157 0.0319
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0308 0.1958 0.1947
Brugia malayi PHD-finger family protein 0.0028 0.0118 0.0921
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0278 0.0264
Echinococcus granulosus peregrin 0.0028 0.0118 0.0104
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0012 0.0014 0.0001
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0034 0.0252
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0047 0.024 0.0226
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0125 0.0112
Schistosoma mansoni hypothetical protein 0.0012 0.0014 0.0028
Echinococcus granulosus transcription factor btf3 0.0038 0.0185 0.0171
Entamoeba histolytica deoxycytidyl transferase, putative 0.0114 0.0681 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0118 0.1287
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0185 0.2119
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0415 0.0844
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0012 0.0014 0.0002
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0049 0.0253 0.0239
Trypanosoma brucei unspecified product 0.0079 0.0449 0.4257
Brugia malayi Inositol-1 0.0032 0.0141 0.11
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0085 0.0491 0.3838
Schistosoma mansoni terminal deoxycytidyl transferase 0.0114 0.0681 0.1386
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0359 0.3381
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0236 0.0479
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0014 0.0001
Schistosoma mansoni hypothetical protein 0.0381 0.2435 0.4953
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0359 0.0731
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.024 0.2213
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0012 0.0014 0.0001
Echinococcus multilocularis transcription factor btf3 0.0038 0.0185 0.0171
Brugia malayi glutamate synthase 0.0012 0.0014 0.0109
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0047 0.024 0.2213

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.8 uM Inhibition of human TP purified from placenta ChEMBL. 16337119
IC50 (binding) = 7.2 uM Inhibition of human TP expressed in V79 cells ChEMBL. 16337119
IC50 (binding) = 8.7 uM Inhibition of Escherichia coli TP ChEMBL. 16337119

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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