Detailed information for compound 373471

Basic information

Technical information
  • TDR Targets ID: 373471
  • Name: 6-(4-chlorophenyl)-3-[2-[(N-methylanilino)met hyl]quinolin-6-yl]thieno[3,2-d]pyrimidin-4-on e
  • MW: 509.021 | Formula: C29H21ClN4OS
  • H donors: 0 H acceptors: 2 LogP: 6.67 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)c1cc2c(s1)c(=O)n(cn2)c1ccc2c(c1)ccc(n2)CN(c1ccccc1)C
  • InChi: 1S/C29H21ClN4OS/c1-33(23-5-3-2-4-6-23)17-22-12-9-20-15-24(13-14-25(20)32-22)34-18-31-26-16-27(36-28(26)29(34)35)19-7-10-21(30)11-8-19/h2-16,18H,17H2,1H3
  • InChiKey: CUOBJGYPCXQATM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(4-chlorophenyl)-3-[2-[(N-methylanilino)methyl]-6-quinolyl]thieno[3,2-d]pyrimidin-4-one
  • 6-(4-chlorophenyl)-3-[2-[(N-methylanilino)methyl]-6-quinolyl]-4-thieno[3,2-d]pyrimidinone
  • 6-(4-chlorophenyl)-3-[2-[[methyl(phenyl)amino]methyl]quinolin-6-yl]thieno[3,2-d]pyrimidin-4-one
  • 6-(4-chlorophenyl)-3-[2-[(methyl-phenylamino)methyl]quinolin-6-yl]thieno[2,3-e]pyrimidin-4-one
  • 6-(4-chlorophenyl)-3-[2-[(methyl-phenyl-amino)methyl]-6-quinolyl]thieno[2,3-e]pyrimidin-4-one
  • 6-(4-chlorophenyl)-3-[2-[(methyl-phenylamino)methyl]-6-quinolyl]-4-thieno[2,3-e]pyrimidinone
  • 6-(4-chlorophenyl)-3-[2-[(methyl-phenyl-amino)methyl]quinolin-6-yl]thieno[2,3-e]pyrimidin-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanin-concentrating hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tubulin alpha chain 0.0096 0.0188 0.0188
Plasmodium falciparum tubulin epsilon chain, putative 0.0096 0.0188 1
Onchocerca volvulus 0.0079 0.0129 0.928
Echinococcus granulosus tubulin alpha chain 0.0096 0.0188 0.0188
Leishmania major epsilon tubulin, putative 0.0096 0.0188 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0005 0.0282
Echinococcus granulosus anosmin 1 0.0043 0.0005 0.0005
Schistosoma mansoni myosin-binding protein-related 0.0079 0.0129 0.6857
Brugia malayi Tubulin alpha-2 chain 0.0096 0.0188 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0129 0.6857
Schistosoma mansoni tubulin subunit gamma 0.0096 0.0188 1
Leishmania major beta tubulin 0.0096 0.0188 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0096 0.0188 1
Trypanosoma brucei beta tubulin 0.0096 0.0188 1
Brugia malayi Lethal protein 805 0.0043 0.0005 0.0282
Echinococcus granulosus EG95 0.0043 0.0005 0.0005
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0043 0.0005 0.0005
Toxoplasma gondii beta-1 tubulin, putative 0.0096 0.0188 1
Trypanosoma brucei alpha tubulin 0.0096 0.0188 1
Loa Loa (eye worm) tubulin beta chain 0.0096 0.0188 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0096 0.0188 0.0188
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0043 0.0005 0.0005
Brugia malayi beta-tubulin, identical 0.0096 0.0188 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0129 0.6857
Echinococcus granulosus Netrin receptor DCC 0.0043 0.0005 0.0005
Brugia malayi tubulin alpha-2 chain 0.0096 0.0188 1
Schistosoma mansoni tubulin subunit beta 0.0096 0.0188 1
Brugia malayi Tubulin alpha-2 chain 0.0096 0.0188 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0129 0.6857
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0129 0.6857
Echinococcus granulosus tubulin alpha chain 0.0096 0.0188 0.0188
Schistosoma mansoni hypothetical protein 0.0043 0.0005 0.0282
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0079 0.0129 0.0129
Echinococcus multilocularis tubulin alpha 0.0096 0.0188 0.0188
Echinococcus granulosus tubulin beta 4A class IVa 0.0096 0.0188 0.0188
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0079 0.0129 0.6857
Brugia malayi Fibronectin type III domain containing protein 0.0043 0.0005 0.0282
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.0188 1
Loa Loa (eye worm) tubulin alpha 2 0.0055 0.0044 0.2326
Mycobacterium leprae cell division protein FtsZ 0.0042 0 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0129 0.6857
Plasmodium falciparum alpha tubulin 2 0.0096 0.0188 1
Echinococcus multilocularis beta tubulin 0.0096 0.0188 0.0188
Schistosoma mansoni tubulin subunit epsilon 0.0096 0.0188 1
Schistosoma mansoni nephrin 0.0079 0.0129 0.6857
Giardia lamblia Beta tubulin 0.0096 0.0188 1
Echinococcus granulosus tubulin alpha 1C chain 0.0096 0.0188 0.0188
Echinococcus granulosus G1Y162 protein 0.0043 0.0005 0.0005
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.0188 1
Schistosoma mansoni tripartite motif protein trim9 0.0043 0.0005 0.0282
Loa Loa (eye worm) hypothetical protein 0.0079 0.0129 0.6857
Leishmania major beta tubulin 0.0096 0.0188 1
Schistosoma mansoni alpha tubulin 0.0096 0.0188 1
Echinococcus granulosus tubulin epsilon chain 0.0096 0.0188 0.0188
Toxoplasma gondii beta tubulin 0.0096 0.0188 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Schistosoma mansoni tubulin subunit beta 0.0096 0.0188 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0005 0.0282
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Echinococcus granulosus usherin 0.0043 0.0005 0.0005
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0096 0.0188 1
Schistosoma mansoni tubulin subunit beta 0.0096 0.0188 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0055 0.0044 0.2326
Echinococcus multilocularis Tubulin beta 2C chain 0.0096 0.0188 0.0188
Brugia malayi hypothetical protein 0.0043 0.0005 0.0282
Schistosoma mansoni alpha tubulin 0.0096 0.0188 1
Echinococcus granulosus tubulin alpha 3 chain 0.0096 0.0188 0.0188
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0079 0.0129 0.6857
Loa Loa (eye worm) alpha-tubulin 0.0096 0.0188 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0096 0.0188 1
Echinococcus multilocularis tubulin alpha chain 0.0096 0.0188 0.0188
Schistosoma mansoni cell adhesion molecule 0.0079 0.0129 0.6857
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0043 0.0005 0.0005
Echinococcus multilocularis Tubulin beta 2C chain 0.0096 0.0188 0.0188
Leishmania major alpha tubulin 0.0096 0.0188 1
Schistosoma mansoni ephrin receptor 0.0043 0.0005 0.0282
Entamoeba histolytica tubulin gamma chain 0.0096 0.0188 0.5
Schistosoma mansoni cell adhesion molecule 0.0079 0.0129 0.6857
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0079 0.0129 0.0129
Giardia lamblia Gamma tubulin 0.0096 0.0188 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0129 0.6857
Leishmania major hypothetical protein, conserved 0.0043 0.0005 0.0282
Treponema pallidum cell division protein FtsZ 0.0042 0 0.5
Trypanosoma brucei alpha tubulin 0.0096 0.0188 1
Schistosoma mansoni protein tyrosine phosphatase 0.0043 0.0005 0.0282
Leishmania major alpha tubulin 0.0096 0.0188 1
Trypanosoma brucei beta tubulin 0.0096 0.0188 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0055 0.0044 0.2326
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0043 0.0005 0.0282
Leishmania major alpha tubulin 0.0096 0.0188 1
Echinococcus multilocularis transfer RNA-Phe 0.0079 0.0129 0.0129
Echinococcus granulosus Tubulin beta 2C chain 0.0096 0.0188 0.0188
Leishmania major beta tubulin 0.0096 0.0188 1
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.0188 1
Leishmania major beta tubulin 0.0096 0.0188 1
Brugia malayi myotactin form A 0.0043 0.0005 0.0282
Echinococcus multilocularis tubulin alpha chain 0.0096 0.0188 0.0188
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0043 0.0005 0.0282
Plasmodium vivax tubulin gamma chain, putative 0.0096 0.0188 1
Plasmodium vivax tubulin alpha chain, putative 0.0096 0.0188 1
Echinococcus granulosus tubulin subunit beta 0.0096 0.0188 0.0188
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0079 0.0129 0.0129
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.0188 1
Schistosoma mansoni cell adhesion molecule 0.0043 0.0005 0.0282
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0079 0.0129 0.6857
Echinococcus granulosus Tubulin alpha 1 chain 0.0096 0.0188 0.0188
Brugia malayi Tubulin beta chain 0.0055 0.0044 0.2326
Brugia malayi alpha-tubulin 0.0096 0.0188 1
Schistosoma mansoni tubulin subunit alpha 0.0096 0.0188 1
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.0188 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0096 0.0188 0.0188
Echinococcus multilocularis tubulin subunit TubB 0.0096 0.0188 0.0188
Schistosoma mansoni nephrin 0.0079 0.0129 0.6857
Echinococcus granulosus Fibronectin type III 0.0043 0.0005 0.0005
Echinococcus multilocularis myosin light chain kinase, smooth muscle 0.2938 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0005 0.0282
Echinococcus granulosus Tubulin beta 2C chain 0.0096 0.0188 0.0188
Echinococcus multilocularis serine:threonine protein kinase 0.2938 1 1
Echinococcus granulosus tubulin alpha chain 0.0096 0.0188 0.0188
Echinococcus multilocularis roundabout 2 0.0079 0.0129 0.0129
Loa Loa (eye worm) tubulin alpha 2 0.0055 0.0044 0.2326
Trypanosoma brucei alpha tubulin 0.0096 0.0188 1
Echinococcus granulosus Fibronectin type III domain containing protein 0.0043 0.0005 0.0005
Brugia malayi Tubulin beta-1 chain 0.0096 0.0188 1
Leishmania major beta tubulin 0.0096 0.0188 1
Echinococcus multilocularis anosmin 1 0.0043 0.0005 0.0005
Schistosoma mansoni hemicentin 0.0079 0.0129 0.6857
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0043 0.0005 0.0005
Leishmania major beta tubulin 0.0096 0.0188 1
Trypanosoma brucei beta tubulin 0.0096 0.0188 1
Leishmania major alpha tubulin 0.0096 0.0188 1
Echinococcus granulosus beta tubulin 0.0096 0.0188 0.0188
Echinococcus granulosus titin 0.0082 0.0139 0.0139
Leishmania major beta tubulin 0.0096 0.0188 1
Trypanosoma brucei beta tubulin 0.0096 0.0188 1
Schistosoma mansoni hypothetical protein 0.0079 0.0129 0.6857
Echinococcus granulosus peroxisome assembly protein 26 0.0096 0.0188 0.0188
Trichomonas vaginalis tubulin epsilon chain, putative 0.0096 0.0188 1
Schistosoma mansoni titin 0.0043 0.0005 0.0282
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0079 0.0129 0.0129
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0043 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0096 0.0188 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0043 0.0005 0.0005
Echinococcus granulosus nephrin 0.0079 0.0129 0.0129
Entamoeba histolytica tubulin alpha chain, putative 0.0096 0.0188 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Echinococcus multilocularis Tubulin alpha 1 chain 0.0096 0.0188 0.0188
Echinococcus multilocularis tubulin alpha 1C chain 0.0096 0.0188 0.0188
Brugia malayi Fibronectin type III domain containing protein 0.0043 0.0005 0.0282
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0043 0.0005 0.0282
Loa Loa (eye worm) projectin 0.0079 0.0129 0.6857
Brugia malayi SPRY domain containing protein 0.0043 0.0005 0.0282
Schistosoma mansoni factor for adipocyte differentiation 0.0043 0.0005 0.0282
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0043 0.0005 0.0282
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0079 0.0129 0.0129
Trypanosoma cruzi epsilon tubulin, putative 0.0096 0.0188 1
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0043 0.0005 0.0282
Trypanosoma cruzi epsilon tubulin, putative 0.0096 0.0188 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0129 0.6857
Trichomonas vaginalis tubulin gamma chain, putative 0.0096 0.0188 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.0188 1
Schistosoma mansoni neuroglian 0.0079 0.0129 0.6857
Trichomonas vaginalis tubulin epsilon chain, putative 0.0096 0.0188 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0096 0.0188 1
Entamoeba histolytica tubulin alpha-1 chain 0.0096 0.0188 0.5
Giardia lamblia Beta tubulin 0.0096 0.0188 1
Echinococcus granulosus tubulin beta 1 chain 0.0096 0.0188 0.0188
Onchocerca volvulus 0.0079 0.0129 0.928
Echinococcus granulosus Tubulin beta 2C chain 0.0096 0.0188 0.0188
Echinococcus multilocularis Fibronectin, type III 0.0043 0.0005 0.0005
Loa Loa (eye worm) CAMK protein kinase 0.0082 0.0139 0.7367
Echinococcus granulosus Tubulin beta 2C chain 0.0096 0.0188 0.0188
Echinococcus multilocularis Tubulin beta 2C chain 0.0096 0.0188 0.0188
Echinococcus multilocularis beta tubulin 0.0096 0.0188 0.0188
Trichomonas vaginalis tubulin alpha chain, putative 0.0055 0.0044 0.2326
Giardia lamblia Beta tubulin 0.0096 0.0188 1
Echinococcus multilocularis tubulin epsilon chain 0.0096 0.0188 0.0188
Brugia malayi Fibronectin type III domain containing protein 0.0043 0.0005 0.0282
Schistosoma mansoni cell adhesion molecule 0.0079 0.0129 0.6857
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0129 0.6857
Echinococcus multilocularis tubulin alpha 3 chain 0.0096 0.0188 0.0188
Echinococcus multilocularis tubulin alpha chain 0.0096 0.0188 0.0188
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0043 0.0005 0.0005
Echinococcus granulosus tubulin alpha 1C chain 0.0096 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Leishmania major beta tubulin 0.0096 0.0188 1
Giardia lamblia Alpha-tubulin 0.0096 0.0188 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0096 0.0188 1
Plasmodium vivax tubulin beta chain, putative 0.0096 0.0188 1
Echinococcus granulosus tubulin gamma 1 chain 0.0096 0.0188 0.0188
Leishmania major alpha tubulin 0.0096 0.0188 1
Leishmania major gamma-tubulin 0.0096 0.0188 1
Brugia malayi myotactin form B 0.0043 0.0005 0.0282
Echinococcus multilocularis Tubulin alpha 1 chain 0.0096 0.0188 0.0188
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0079 0.0129 0.6857
Echinococcus multilocularis tubulin subunit beta 0.0096 0.0188 0.0188
Mycobacterium tuberculosis Cell division protein FtsZ 0.0042 0 0.5
Leishmania major beta tubulin 0.0096 0.0188 1
Trichomonas vaginalis tubulin, putative 0.0055 0.0044 0.2326
Brugia malayi protein unc-22 0.0082 0.0139 0.7367
Plasmodium vivax tubulin alpha chain, putative 0.0096 0.0188 1
Echinococcus granulosus neuroglian 0.0079 0.0129 0.0129
Echinococcus granulosus Netrin receptor DCC 0.0043 0.0005 0.0005
Echinococcus granulosus cell adhesion molecule 0.0043 0.0005 0.0005
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0043 0.0005 0.0282
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0043 0.0005 0.0282
Loa Loa (eye worm) tubulin beta-2A chain 0.0096 0.0188 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0096 0.0188 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0043 0.0005 0.0005
Trypanosoma brucei tubulin gamma chain 0.0096 0.0188 1
Trypanosoma brucei alpha tubulin 0.0096 0.0188 1
Schistosoma mansoni tubulin subunit beta 0.0096 0.0188 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0043 0.0005 0.0282
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0043 0.0005 0.0282
Leishmania major beta tubulin 0.0096 0.0188 1
Leishmania major beta tubulin 0.0096 0.0188 1
Entamoeba histolytica tubulin family protein 0.0096 0.0188 0.5
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0082 0.0139 0.7367
Echinococcus multilocularis titin 0.0082 0.0139 0.0139
Brugia malayi Fibronectin type III domain containing protein 0.0043 0.0005 0.0282
Echinococcus multilocularis usherin 0.0043 0.0005 0.0005
Schistosoma mansoni tubulin subunit beta 0.0096 0.0188 1
Echinococcus multilocularis titin 0.0043 0.0005 0.0005
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0043 0.0005 0.0282
Trichomonas vaginalis tubulin alpha chain, putative 0.0055 0.0044 0.2326
Brugia malayi Fibronectin type III domain containing protein 0.0043 0.0005 0.0282
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0055 0.0044 0.2326
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0055 0.0044 0.2326
Brugia malayi Immunoglobulin I-set domain containing protein 0.0082 0.0139 0.7367
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0042 0 0.5
Echinococcus granulosus roundabout 2 0.0079 0.0129 0.0129
Schistosoma mansoni titin 0.0082 0.0139 0.7367
Echinococcus multilocularis peroxisome assembly protein 26 0.0096 0.0188 0.0188
Leishmania major alpha tubulin 0.0096 0.0188 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Echinococcus multilocularis anosmin 1 0.0043 0.0005 0.0005
Echinococcus multilocularis Tubulin alpha 1 chain 0.0096 0.0188 0.0188
Leishmania major alpha tubulin 0.0096 0.0188 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0082 0.0139 0.7367
Leishmania major beta tubulin 0.0096 0.0188 1
Trichomonas vaginalis tubulin beta chain, putative 0.0055 0.0044 0.2326
Echinococcus multilocularis tubulin alpha chain 0.0096 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Brugia malayi Tubulin gamma chain 0.0096 0.0188 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0129 0.6857
Leishmania major beta tubulin 0.0096 0.0188 1
Leishmania major beta tubulin 0.0096 0.0188 1
Echinococcus granulosus tubulin alpha 0.0096 0.0188 0.0188
Schistosoma mansoni tubulin subunit alpha 0.0096 0.0188 1
Schistosoma mansoni factor for adipocyte differentiation 0.0043 0.0005 0.0282
Trypanosoma brucei epsilon tubulin 0.0096 0.0188 1
Loa Loa (eye worm) BEN-1 protein 0.0096 0.0188 1
Leishmania major alpha tubulin 0.0096 0.0188 1
Loa Loa (eye worm) tubulin alpha chain 0.0096 0.0188 1
Trypanosoma brucei epsilon tubulin 0.0096 0.0188 1
Echinococcus granulosus roundabout 2 0.0079 0.0129 0.0129
Brugia malayi Fibronectin type III domain containing protein 0.0043 0.0005 0.0282
Leishmania major beta tubulin 0.0096 0.0188 1
Mycobacterium ulcerans cell division protein FtsZ 0.0042 0 0.5
Loa Loa (eye worm) BEN-1 protein 0.0096 0.0188 1
Echinococcus granulosus alpha tubulin 0.0096 0.0188 0.0188
Echinococcus multilocularis roundabout 2 0.0079 0.0129 0.0129
Leishmania major beta tubulin 0.0096 0.0188 1
Loa Loa (eye worm) lethal protein 805 0.0043 0.0005 0.0282
Trichomonas vaginalis tubulin, putative 0.0055 0.0044 0.2326
Echinococcus multilocularis cell adhesion molecule 0.0043 0.0005 0.0005
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0043 0.0005 0.0282
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Loa Loa (eye worm) UNCoordinated family member 0.0043 0.0005 0.0282
Loa Loa (eye worm) tubulin gamma chain 0.0096 0.0188 1
Leishmania major alpha tubulin 0.0096 0.0188 1
Plasmodium falciparum alpha tubulin 1 0.0096 0.0188 1
Giardia lamblia Alpha-tubulin 0.0096 0.0188 1
Echinococcus multilocularis roundabout 2 0.0079 0.0129 0.0129
Echinococcus granulosus anosmin 1 0.0043 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Echinococcus granulosus tubulin alpha 3 chain 0.0096 0.0188 0.0188
Schistosoma mansoni hypothetical protein 0.0043 0.0005 0.0282
Trypanosoma cruzi beta tubulin, putative 0.0096 0.0188 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0079 0.0129 0.6857
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Loa Loa (eye worm) alpha-tubulin 0.0096 0.0188 1
Echinococcus multilocularis neuroglian 0.0079 0.0129 0.0129
Echinococcus granulosus tubulin subunit TubB 0.0096 0.0188 0.0188
Echinococcus multilocularis tubulin gamma 1 chain 0.0096 0.0188 0.0188
Plasmodium falciparum tubulin beta chain 0.0096 0.0188 1
Brugia malayi Protein-tyrosine phosphatase 0.0043 0.0005 0.0282
Schistosoma mansoni titin 0.0079 0.0129 0.6857
Loa Loa (eye worm) tubulin alpha-2 chain 0.0096 0.0188 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0043 0.0005 0.0005
Echinococcus granulosus serine:threonine protein kinase 0.2938 1 1
Trypanosoma brucei epsilon tubulin 0.0096 0.0188 1
Onchocerca volvulus 0.0055 0.0044 0.2885
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Trypanosoma cruzi alpha tubulin, putative 0.0096 0.0188 1
Loa Loa (eye worm) tubulin alpha chain 0.0096 0.0188 1
Brugia malayi hypothetical protein 0.0043 0.0005 0.0282
Echinococcus multilocularis tubulin alpha 1C chain 0.0096 0.0188 0.0188
Leishmania major beta tubulin 0.0096 0.0188 1
Toxoplasma gondii alpha tubulin TUBA1 0.0096 0.0188 1
Schistosoma mansoni tubulin subunit beta 0.0096 0.0188 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0043 0.0005 0.0282
Schistosoma mansoni alpha tubulin 0.0096 0.0188 1
Trichomonas vaginalis tubulin, putative 0.0096 0.0188 1
Toxoplasma gondii alpha-tubulin I, putative 0.0096 0.0188 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0096 0.0188 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0096 0.0188 0.0188
Loa Loa (eye worm) beta-tubulin 0.0096 0.0188 1
Brugia malayi Lethal protein 805 0.0043 0.0005 0.0282
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.0188 1
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0043 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0043 0.0005 0.0282
Trypanosoma cruzi tubulin gamma chain 0.0096 0.0188 1
Leishmania major beta tubulin 0.0096 0.0188 1
Echinococcus granulosus Tubulin beta 2C chain 0.0096 0.0188 0.0188
Echinococcus granulosus Tubulin alpha 1 chain 0.0096 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0055 0.0044 0.2326
Echinococcus multilocularis anosmin 1 0.0043 0.0005 0.0005
Leishmania major alpha tubulin 0.0096 0.0188 1
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0043 0.0005 0.0282
Echinococcus multilocularis Tubulin beta 2C chain 0.0096 0.0188 0.0188
Echinococcus multilocularis Netrin receptor DCC 0.0043 0.0005 0.0005
Toxoplasma gondii beta-tubulin, putative 0.0096 0.0188 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Echinococcus multilocularis tubulin alpha chain 0.0096 0.0188 0.0188
Plasmodium falciparum tubulin gamma chain 0.0096 0.0188 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0096 0.0188 1
Leishmania major alpha tubulin 0.0096 0.0188 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0079 0.0129 0.0129
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0043 0.0005 0.0005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0079 0.0129 0.6857
Schistosoma mansoni factor for adipocyte differentiation 0.0043 0.0005 0.0282
Echinococcus multilocularis Netrin receptor DCC 0.0043 0.0005 0.0005
Echinococcus granulosus contactin 0.0079 0.0129 0.0129
Echinococcus granulosus anosmin 1 0.0043 0.0005 0.0005
Plasmodium vivax tubulin epsilon chain, putative 0.0096 0.0188 1
Echinococcus granulosus beta tubulin 0.0096 0.0188 0.0188
Loa Loa (eye worm) myotactin form A 0.0043 0.0005 0.0282
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0096 0.0188 0.0188
Leishmania major alpha tubulin 0.0096 0.0188 1
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0139 0.7367
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0043 0.0005 0.0005
Echinococcus granulosus titin 0.0082 0.0139 0.0139
Trypanosoma brucei beta tubulin 0.0096 0.0188 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0096 0.0188 1
Echinococcus granulosus fibronectin type III domain-containing protein 0.0043 0.0005 0.0005
Echinococcus multilocularis tubulin beta 1 chain 0.0096 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0079 0.0129 0.6857
Brugia malayi tubulin alpha chain - mouse 0.0096 0.0188 1
Onchocerca volvulus 0.0082 0.0139 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0043 0.0005 0.0282
Echinococcus multilocularis hypothetical protein 0.0096 0.0188 0.0188
Echinococcus granulosus roundabout 2 0.0079 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Entamoeba histolytica tubulin family protein 0.0096 0.0188 0.5
Schistosoma mansoni tubulin subunit alpha 0.0096 0.0188 1
Trypanosoma brucei alpha tubulin, putative 0.0055 0.0044 0.2326
Echinococcus granulosus tubulin alpha chain 0.0096 0.0188 0.0188
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0043 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0005 0.0282
Trichomonas vaginalis tubulin alpha chain, putative 0.0096 0.0188 1
Brugia malayi Tubulin alpha chain 0.0096 0.0188 1
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0043 0.0005 0.0005
Schistosoma mansoni cell adhesion molecule 0.0079 0.0129 0.6857

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 87 nM Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay ChEMBL. 17125262
IC50 (functional) = 87 nM Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay ChEMBL. 17125262

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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