Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0368 | 0.4788 | 1 |
Mycobacterium tuberculosis | Probable peptidase | 0.0031 | 0.016 | 0.0227 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0287 | 0.0287 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.0046 | 0.009 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0454 | 0.0895 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0591 | 0.1166 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0052 | 0.0054 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0591 | 0.0591 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.0046 | 0.009 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.0532 | 0.0532 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0031 | 0.016 | 0.016 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0031 | 0.016 | 0.0886 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0056 | 0.1423 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0388 | 0.5067 | 0.5067 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0368 | 0.4788 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0346 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.016 | 0.0315 |
Echinococcus multilocularis | snurportin 1 | 0.0305 | 0.3934 | 0.3934 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0387 | 0.0387 |
Loa Loa (eye worm) | glutamate receptor | 0.008 | 0.0837 | 0.1651 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.013 | 0.013 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0048 | 0.0393 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0037 | 0.0037 |
Brugia malayi | Inositol-1 | 0.004 | 0.0287 | 0.0565 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0031 | 0.016 | 0.1044 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0591 | 0.0591 |
Brugia malayi | follicle stimulating hormone receptor | 0.0232 | 0.2931 | 0.5784 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0346 | 0.0346 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.0229 | 0.0373 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.3178 | 0.6272 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0144 | 0.0783 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0082 | 0.0857 | 0.0857 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0027 | 0.0027 |
Schistosoma mansoni | hypothetical protein | 0.0281 | 0.3598 | 0.3598 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0203 | 0.2532 | 0.4997 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0056 | 0.01 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.013 | 0.0218 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0591 | 0.1166 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.013 | 0.0257 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0368 | 0.4788 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0388 | 0.5067 | 1 |
Onchocerca volvulus | 0.0235 | 0.2966 | 0.5855 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0591 | 0.1166 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0368 | 0.4788 | 1 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0368 | 0.4788 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0046 | 0.0372 | 0.0735 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0082 | 0.0857 | 0.0857 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0368 | 0.4788 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0144 | 0.0144 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0046 | 0.0372 | 0.0372 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.013 | 0.1529 | 0.1529 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0182 | 0.224 | 0.224 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0388 | 0.5067 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0031 | 0.016 | 0.0453 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0056 | 0.01 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0031 | 0.016 | 0.406 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0031 | 0.016 | 0.016 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0368 | 0.4788 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0679 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.028 | 0.0552 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0182 | 0.224 | 0.224 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0216 | 0.0216 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.013 | 0.0691 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0184 | 0.2269 | 0.4479 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0031 | 0.016 | 0.1044 |
Leishmania major | hypothetical protein, conserved | 0.0091 | 0.0991 | 0.6481 |
Echinococcus multilocularis | geminin | 0.0168 | 0.2047 | 0.2047 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.013 | 0.0218 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0591 | 0.0591 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0082 | 0.0857 | 0.1692 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0232 | 0.2931 | 0.5784 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0046 | 0.0372 | 0.0372 |
Echinococcus granulosus | geminin | 0.0168 | 0.2047 | 0.2047 |
Echinococcus granulosus | prolyl endopeptidase | 0.0031 | 0.016 | 0.016 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.0052 | 0.0171 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0287 | 0.0884 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0591 | 0.1166 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0052 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0346 | 0.0346 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0033 | 0.0191 | 0.0191 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0048 | 0.0393 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0346 | 0.0346 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0033 | 0.0191 | 0.0377 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.013 | 0.1529 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0046 | 0.0372 | 0.0735 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0388 | 0.5067 | 0.5067 |
Brugia malayi | Pre-SET motif family protein | 0.0206 | 0.2574 | 0.5081 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0031 | 0.016 | 0.1044 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0287 | 0.1874 |
Toxoplasma gondii | hypothetical protein | 0.0031 | 0.016 | 0.0886 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0591 | 0.1166 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0387 | 0.0387 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.046 | 0.0908 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0053 | 0.046 | 0.046 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0052 | 0.0454 | 0.0895 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.0287 | 0.0495 |
Schistosoma mansoni | ran | 0.0021 | 0.0027 | 0.0027 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0591 | 0.0591 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0216 | 0.0216 |
Schistosoma mansoni | ran | 0.0021 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0305 | 0.3934 | 0.7764 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0052 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0305 | 0.3934 | 0.3934 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0012 | 0.0024 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0027 | 0.0173 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.017 | 0.2078 | 0.2078 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0052 | 0.0454 | 0.0895 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0591 | 0.0591 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0591 | 0.0591 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0031 | 0.016 | 0.0227 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0747 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0031 | 0.016 | 0.0315 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0031 | 0.016 | 0.016 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.017 | 0.2078 | 0.2078 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0046 | 0.0372 | 0.0372 |
Trypanosoma cruzi | oligopeptidase b | 0.0031 | 0.016 | 0.1044 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0.016 | 0.0453 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0048 | 0.0393 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0857 | 0.1692 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0591 | 0.1166 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.0229 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0371 | 0.0733 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0287 | 0.0884 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2923 | 0.5769 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0031 | 0.016 | 0.016 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.0287 | 0.0495 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0346 | 0.0346 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0023 | 0.0052 | 0.0171 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0046 | 0.0372 | 0.0372 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0231 | 0.2915 | 0.2915 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0031 | 0.016 | 0.406 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0052 | 0.1328 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0099 | 0.1099 | 0.217 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0027 | 0.0027 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.0855 | 0.1688 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0129 | 0.0129 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.0247 | 0.0488 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0031 | 0.016 | 0.0227 |
Onchocerca volvulus | 0.003 | 0.0144 | 0.0285 | |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0388 | 0.5067 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0388 | 0.5067 | 0.5067 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.0372 | 0.0372 |
Onchocerca volvulus | 0.0047 | 0.0387 | 0.0764 | |
Trypanosoma cruzi | prolyl endopeptidase | 0.0031 | 0.016 | 0.1044 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0053 | 0.046 | 0.0908 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0027 | 0.0052 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0027 | 0.0173 |
Plasmodium falciparum | peptidase, putative | 0.0031 | 0.016 | 0.028 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0031 | 0.016 | 0.0315 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0031 | 0.016 | 0.406 |
Leishmania major | oligopeptidase b | 0.0031 | 0.016 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0191 | 0.0377 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.0031 | 0.016 | 0.0886 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0046 | 0.0371 | 0.0371 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0046 | 0.0372 | 0.0372 |
Trypanosoma brucei | oligopeptidase b | 0.0031 | 0.016 | 0.0886 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0056 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0305 | 0.0602 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0027 | 0.0674 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.0287 | 0.0287 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0099 | 0.1099 | 0.1099 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0387 | 0.0764 |
Echinococcus multilocularis | DNA dependent protein kinase catalytic subunit | 0.0251 | 0.319 | 0.319 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0027 | 0.0173 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 0.2923 | 0.2923 |
Brugia malayi | hypothetical protein | 0.01 | 0.1107 | 0.2184 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0287 | 0.1874 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0046 | 0.0371 | 0.0371 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0046 | 0.0371 | 0.0371 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0144 | 0.0144 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.0287 | 0.0287 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0023 | 0.0052 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0248 | 0.049 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.013 | 0.1529 | 0.1529 |
Loa Loa (eye worm) | glutamate receptor | 0.0203 | 0.2532 | 0.4997 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0037 | 0.0037 |
Brugia malayi | prolyl oligopeptidase family protein | 0.013 | 0.1529 | 0.3018 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0012 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0191 | 0.0191 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0031 | 0.016 | 0.1044 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.2047 | 0.2047 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0037 | 0.0037 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0144 | 0.0247 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0287 | 0.1874 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0144 | 0.0144 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0046 | 0.0371 | 0.0371 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0287 | 0.0287 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0053 | 0.046 | 0.046 |
Trichomonas vaginalis | set domain proteins, putative | 0.0235 | 0.2966 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.013 | 0.0257 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.0287 | 0.173 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.016 | 0.0315 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0082 | 0.0857 | 0.0857 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0031 | 0.016 | 0.0315 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.013 | 0.1529 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0031 | 0.016 | 0.0315 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0591 | 0.0591 |
Echinococcus granulosus | snurportin 1 | 0.0305 | 0.3934 | 0.3934 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.013 | 0.1529 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0031 | 0.016 | 0.0886 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0056 | 0.01 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0053 | 0.046 | 0.046 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0031 | 0.016 | 0.406 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 0.2923 | 0.2923 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.0532 | 0.0532 |
Onchocerca volvulus | 0.0046 | 0.0372 | 0.0735 | |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0031 | 0.016 | 1 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0033 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0372 | 0.0735 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0031 | 0.016 | 0.1044 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0033 | 0.0191 | 0.0377 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0031 | 0.016 | 0.6077 |
Toxoplasma gondii | prolyl endopeptidase | 0.0031 | 0.016 | 0.0886 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0372 | 0.0735 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0056 | 0.0366 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0053 | 0.046 | 0.046 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0031 | 0.016 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.016 | 0.0315 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0048 | 0.0393 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0031 | 0.016 | 0.406 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.0287 | 0.0884 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0346 | 0.0346 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.0069 | 0.0136 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.2047 | 0.2047 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0206 | 0.2574 | 0.5081 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.0287 | 0.7287 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.0372 | 0.0372 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.0736 | 0.1452 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0031 | 0.016 | 0.0886 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0747 | 1 | 1 |
Onchocerca volvulus | 0.0082 | 0.0857 | 0.1692 | |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0031 | 0.016 | 0.016 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0088 | 0.0945 | 0.6179 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0052 | 0.0454 | 0.0895 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.017 | 0.2078 | 0.2078 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0027 | 0.0052 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.025 | 0.3178 | 0.3178 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0346 | 0.0683 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0031 | 0.016 | 0.406 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0053 | 0.046 | 0.046 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.1107 | 0.2184 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0048 | 0.0393 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0031 | 0.016 | 0.016 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.013 | 0.0691 |
Trypanosoma cruzi | oligopeptidase b | 0.0031 | 0.016 | 0.1044 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0031 | 0.016 | 0.0315 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0287 | 0.173 |
Echinococcus granulosus | DNA dependent protein kinase catalytic subunit | 0.0251 | 0.319 | 0.319 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0031 | 0.016 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0144 | 0.0285 |
Brugia malayi | hypothetical protein | 0.0232 | 0.2923 | 0.5769 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.013 | 0.013 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.0287 | 0.0565 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0033 | 0.0191 | 0.0377 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0023 | 0.0052 | 0.0171 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.013 | 0.1529 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0346 | 0.0346 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0372 | 0.0735 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0346 | 0.0683 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0031 | 0.016 | 0.016 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.058 | 0.058 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.013 | 0.1529 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.016 | 0.028 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0368 | 0.4788 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.013 | 0.013 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0031 | 0.016 | 0.1044 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.013 | 0.0691 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0031 | 0.016 | 0.0886 |
Loa Loa (eye worm) | MBCTL1 | 0.0053 | 0.046 | 0.0908 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.025 | 0.3178 | 0.3178 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.013 | 0.1529 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.013 | 0.1529 | 0.1529 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.95 mg kg-1 | Subcutaneously administration into mice infected with Streptococcus pyogenes C 203 | ChEMBL. | 2530352 |
ED50 (functional) | = 0.95 mg kg-1 | Efficacy of compound administered subcutaneously against Streptococcus pyogenes L 49 Septicemia in mouse | ChEMBL. | 1433211 |
ED50 (functional) | = 0.95 mg kg-1 | Minmum inhibitory concentration of the compound administered intravenously against Streptococcus pyogenes C203 in mouse | ChEMBL. | 2522992 |
Ka (binding) | = 0.0003 M-1 | Association constant with Ac2-L-Lys-D-Ala-D-Ala | ChEMBL. | 2530352 |
Ka (ADMET) | = 30000 M-1 | Association constant of compound was evaluated at pH 9 | ChEMBL. | 2522992 |
KA (ADMET) | = 180000 M-1 | Association constant for compound at 31 degree C was determined | ChEMBL. | 2521516 |
Ka (ADMET) | = 250000 M-1 | Association constant of compound was evaluated at pH 5 | ChEMBL. | 2522992 |
logD (ADMET) | = 0.3 | Partition coefficient (logD6.0) (1-butanol) | ChEMBL. | 2530352 |
MIC (functional) | <= 0.125 mg ml-1 | Minimum inhibitory concentration against 559 Enterococcus faecalis (isogenic of L 560) | ChEMBL. | 16099650 |
MIC (functional) | <= 0.125 mg ml-1 | Minimum inhibitory concentration against 568 Enterococcus faecium (isogenic of L569) | ChEMBL. | 16099650 |
MIC (functional) | <= 0.125 mg ml-1 | Minimum inhibitory concentration against 49 Streptococcus pyogenes C203 | ChEMBL. | 16099650 |
MIC (functional) | <= 0.125 mg ml-1 | Minimum inhibitory concentration against 1139 Enterococcus faecalis teico-vanco-sensitive | ChEMBL. | 16099650 |
MIC (functional) | = 1 mg ml-1 | Minimum inhibitory concentration against 819 Staphylococcus aureus Smith MSSA | ChEMBL. | 16099650 |
MIC (functional) | = 1 mg ml-1 | Minimum inhibitory concentration against 613 Staphylococcus aureus Clin. isolate Met-R | ChEMBL. | 16099650 |
MIC (functional) | = 1 mg ml-1 | Minimum inhibitory concentration against 1400 Staphylococcus aureus Clin. isolate Met-R | ChEMBL. | 16099650 |
MIC (functional) | = 2 mg ml-1 | Minimum inhibitory concentration against 147 Staphylococcus epidermidis ATCC 12228 | ChEMBL. | 16099650 |
MIC (functional) | = 4 mg ml-1 | Minimum inhibitory concentration against 3798 Staphylococcus aureus Clin. isolate VISA | ChEMBL. | 16099650 |
MIC (functional) | = 16 mg ml-1 | Minimum inhibitory concentration against 3797 Staphylococcus aureus Clin. isolate VISA | ChEMBL. | 16099650 |
MIC (functional) | = 128 mg ml-1 | Minimum inhibitory concentration against 559 Enterococcus faecalis Van-A | ChEMBL. | 16099650 |
MIC (functional) | > 128 mg ml-1 | Minimum inhibitory concentration against 569 Enterococcus faecium clin. isolate Van-A | ChEMBL. | 16099650 |
MIC (functional) | > 128 mg ml-1 | Minimum inhibitory concentration against 2215 Enterococcus faecium clin. isolate Van-A | ChEMBL. | 16099650 |
MIC (functional) | > 128 mg ml-1 | Minimum inhibitory concentration against 2981 Enterococcus faecalis clin. Isolate Van-A | ChEMBL. | 16099650 |
MIC (functional) | = 0.016 ug ml-1 | In vitro minimum inhibitory concentration against Staphylococcus epidermis ATCC 12228 | ChEMBL. | 2530352 |
MIC (functional) | = 0.016 ug ml-1 | Minimal inhibitory concentration of compound against Streptococcus epidermidis ATCC12228 | ChEMBL. | 2521516 |
MIC (functional) | = 0.016 ug ml-1 | Minimum inhibitory concentration against Staphylococcus epidermidis ATCC 12228 | ChEMBL. | 1433211 |
MIC (functional) | = 0.016 ug ml-1 | Minmum inhibitory concentration of the compound against Staphylococcus epidermis ATCC12228 evaluated in vitro | ChEMBL. | 2522992 |
MIC (functional) | = 0.06 ug ml-1 | In vitro minimum inhibitory concentration against Staphylococcus aureus Tour | ChEMBL. | 2530352 |
MIC (functional) | = 0.06 ug ml-1 | Minimal inhibitory concentration of compound against Staphylococcus aureus Tour | ChEMBL. | 2521516 |
MIC (functional) | = 0.063 ug ml-1 | Minimum inhibitory concentration against Staphylococcus aureus L 165 | ChEMBL. | 1433211 |
MIC (functional) | = 0.063 ug ml-1 | Minmum inhibitory concentration of the compound against Staphylococcus aureus Tour evaluated in vitro | ChEMBL. | 2522992 |
MIC (functional) | = 0.063 ug ml-1 | Minmum inhibitory concentration of the compound against Staphylococcus epidermis L1378 evaluated in vitro | ChEMBL. | 2522992 |
MIC (functional) | = 0.063 ug ml-1 | Minmum inhibitory concentration of the compound against Staphylococcus simulans L785 evaluated in vitro | ChEMBL. | 2522992 |
MIC (functional) | = 0.063 ug ml-1 | Minmum inhibitory concentration of the compound against Staphylococcus simulans L1142 evaluated in vitro | ChEMBL. | 2522992 |
MIC (functional) | = 0.063 ug ml-1 | Minmum inhibitory concentration of the compound against Staphylococcus hominis L1070 evaluated in vitro | ChEMBL. | 2522992 |
MIC (functional) | = 0.12 ug ml-1 | In vitro minimum inhibitory concentration against Streptococcus pyogenes C 203 | ChEMBL. | 2530352 |
MIC (functional) | = 0.12 ug ml-1 | In vitro minimum inhibitory concentration against Streptococcus pneumoniae UC41 | ChEMBL. | 2530352 |
MIC (functional) | = 0.12 ug ml-1 | In vitro minimum inhibitory concentration against Streptococcus faecalis ATCC 7080 | ChEMBL. | 2530352 |
MIC (functional) | = 0.12 ug ml-1 | Minimal inhibitory concentration of compound against Staphylococcus aureus Tour in an inoculum of 10e6 cfu/mL | ChEMBL. | 2521516 |
MIC (functional) | = 0.12 ug ml-1 | Minimal inhibitory concentration of compound against Streptococcus pyogenes C203 | ChEMBL. | 2521516 |
MIC (functional) | = 0.12 ug ml-1 | Minimal inhibitory concentration of compound against Streptococcus pnemoniae UC41 | ChEMBL. | 2521516 |
MIC (functional) | = 0.12 ug ml-1 | Minimal inhibitory concentration of compound against Streptococcus faecalis AACC7080 | ChEMBL. | 2521516 |
MIC (functional) | = 0.125 ug ml-1 | Minimum inhibitory concentration against Streptococcus pyogenes L 49 | ChEMBL. | 1433211 |
MIC (functional) | = 0.125 ug ml-1 | Minimum inhibitory concentration against Streptococcus pneumoniae L 44 | ChEMBL. | 1433211 |
MIC (functional) | = 0.125 ug ml-1 | Minimum inhibitory concentration against Enterococcus faecalis ATCC 7080 | ChEMBL. | 1433211 |
MIC (functional) | = 0.125 ug ml-1 | Minmum inhibitory concentration of the compound against Streptococcus pyogenes C 203 evaluated in vitro | ChEMBL. | 2522992 |
MIC (functional) | = 0.125 ug ml-1 | Minmum inhibitory concentration of the compound against Streptococcus pneumoniae UC 41 evaluated in vitro | ChEMBL. | 2522992 |
MIC (functional) | = 0.125 ug ml-1 | Minmum inhibitory concentration of the compound against Streptococcus faecalis ATCC 7080 evaluated in vitro | ChEMBL. | 2522992 |
MIC (functional) | = 0.125 ug ml-1 | Minmum inhibitory concentration of the compound against Staphylococcus haemolyticus L1520 evaluated in vitro | ChEMBL. | 2522992 |
MIC (functional) | = 0.13 ug ml-1 | Minimum inhibitory concentration of compound was determined against Streptococcus pyogenes L 49 in mouse | ChEMBL. | 1433211 |
MIC (functional) | = 0.13 ug ml-1 | Antibacterial activity against glycopeptide susceptible Enterococcus faecium 568 strain | ChEMBL. | 12646030 |
MIC (functional) | = 0.13 ug ml-1 | Antibacterial activity against glycopeptide susceptible Enterococcus faecalis 559 strain | ChEMBL. | 12646030 |
MIC (functional) | = 0.25 ug ml-1 | In vitro minimum inhibitory concentration against Staphylococcus hemolyticus 602 cell line | ChEMBL. | 2530352 |
MIC (functional) | = 0.25 ug ml-1 | Minimal inhibitory concentration of compound against Staphylococcus aureus Tour determined in iso-sensitest broth with an inoculum of 10e4 cfu/mL | ChEMBL. | 2521516 |
MIC (functional) | = 0.25 ug ml-1 | Minimum inhibitory concentration against Staphylococcus haemolyticus L 602 | ChEMBL. | 1433211 |
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against Staphylococcus epidermis 533 strain | ChEMBL. | 12646030 |
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against Streptococcus haemolyticus 602 strain | ChEMBL. | 12646030 |
MIC (functional) | = 0.25 ug ml-1 | Minmum inhibitory concentration of the compound against Staphylococcus warneri L1375 evaluated in vitro | ChEMBL. | 2522992 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against glycopeptide intermediate resistant Staphylococcus aureus 3797 strain | ChEMBL. | 12646030 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against glycopeptide intermediate resistant Staphylococcus aureus 3798 strain | ChEMBL. | 12646030 |
MIC (functional) | = 64 ug ml-1 | In vitro minimum inhibitory concentration against E. coli SKF 12140 | ChEMBL. | 2530352 |
MIC (functional) | = 64 ug ml-1 | Minimum inhibitory concentration against Escherichia coli L 47 | ChEMBL. | 1433211 |
MIC (functional) | = 128 ug ml-1 | In vitro minimum inhibitory concentration against Proteus vulgaris X 19 ATCC 881 | ChEMBL. | 2530352 |
MIC (functional) | > 128 ug ml-1 | In vitro minimum inhibitory concentration against P. aeruginosa ATCC 10145 | ChEMBL. | 2530352 |
MIC (functional) | = 128 ug ml-1 | Minimum inhibitory concentration against Proteus vulgaris ATCC 881 | ChEMBL. | 1433211 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory concentration against Pseudomonas aeruginosa ATCC 10145 | ChEMBL. | 1433211 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against glycopeptide resistant Enterococcus faecium 569 strain | ChEMBL. | 12646030 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against glycopeptide resistant Enterococcus faecalis 560 strain | ChEMBL. | 12646030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
6 literature references were collected for this gene.