Detailed information for compound 42691

Basic information

Technical information
  • TDR Targets ID: 42691
  • Name: 2-(dibutylamino)-N-(1-methyl-2,3-dihydropyrro lo[2,3-b]quinolin-4-yl)acetamide
  • MW: 368.516 | Formula: C22H32N4O
  • H donors: 1 H acceptors: 2 LogP: 4.43 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(CC(=O)Nc1c2CCN(c2nc2c1cccc2)C)CCCC
  • InChi: 1S/C22H32N4O/c1-4-6-13-26(14-7-5-2)16-20(27)24-21-17-10-8-9-11-19(17)23-22-18(21)12-15-25(22)3/h8-11H,4-7,12-16H2,1-3H3,(H,23,24,27)
  • InChiKey: OPQOYUFUFWQEFT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(dibutylamino)-N-(1-methyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-yl)ethanamide
  • CBDivE_006355
  • BAS 00232122

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis voltage dependent calcium channel subunit 0.013 0.1448 0.1445
Onchocerca volvulus 0.0049 0.0475 0.1606
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0218 0.0431
Onchocerca volvulus 0.0021 0.0135 0.0403
Echinococcus multilocularis musashi 0.0054 0.0529 0.0526
Loa Loa (eye worm) hypothetical protein 0.0026 0.0193 0.0494
Brugia malayi Cytochrome P450 family protein 0.0022 0.0142 0.0565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0218 0.056
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0023 0.0159 0.0632
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0118 0.0115
Onchocerca volvulus 0.0014 0.0045 0.0081
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0286 0.8121
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0218 0.0871
Brugia malayi hypothetical protein 0.0013 0.0039 0.0148
Loa Loa (eye worm) hypothetical protein 0.0032 0.0259 0.0667
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0022 0.0079
Echinococcus granulosus voltage dependent calcium channel subunit 0.013 0.1448 0.29
Schistosoma mansoni laminin gamma-3 chain 0.0023 0.0159 0.0319
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0126 0.3505
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0193 0.019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0218 0.0871
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0135 0.0652
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0039 0.0148
Schistosoma mansoni hypothetical protein 0.0175 0.1994 0.4
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0296 0.0762
Schistosoma mansoni loxhd1 0.002 0.0125 0.025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0238 0.047
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0118 0.0115
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0045 0.0108
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0351 1
Schistosoma mansoni ap endonuclease 0.0039 0.0351 0.0704
Schistosoma mansoni hypothetical protein 0.0256 0.2967 0.5953
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0286 0.3329 0.3326
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0351 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0022 0.0037
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0218 0.0431
Trypanosoma cruzi UDP-galactopyranose mutase 0.0022 0.0148 0.4146
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0022 0.0148 0.5
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0286 0.1354
Toxoplasma gondii aminopeptidase N protein 0.0012 0.0022 0.0104
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.2484 0.6469
Brugia malayi nuclear receptor NHR-88 0.0013 0.0039 0.0148
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0218 0.0431
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0118 0.0237
Echinococcus granulosus pikachurin 0.0023 0.0159 0.0312
Brugia malayi hypothetical protein 0.002 0.0125 0.0495
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0126 0.3594
Echinococcus granulosus axis inhibition protein axin 0.002 0.0118 0.023
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.4984 0.4982
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0022 0.0486
Toxoplasma gondii microneme protein MIC17B 0.0014 0.0045 0.0215
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0351 0.1167
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0118 0.023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0218 0.0871
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0653 0.131
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0118 0.0299
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0022 0.0078
Loa Loa (eye worm) hypothetical protein 0.0328 0.3838 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0182 0.5126
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0022 0.0148 0.0145
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0022 0.0486
Schistosoma mansoni aldehyde dehydrogenase 0.0182 0.2076 0.4165
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0126 0.0123
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0.0039 0.0078
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0045 0.0215
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0259 0.0514
Loa Loa (eye worm) hypothetical protein 0.0025 0.0181 0.0463
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0022 0.0486
Brugia malayi hypothetical protein 0.0022 0.0148 0.059
Echinococcus granulosus neurogenic locus notch protein 0.0023 0.0159 0.0312
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0039 0.0148
Brugia malayi nuclear hormone receptor 0.0028 0.0218 0.0871
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0012 0.0022 0.0043
Schistosoma mansoni hypothetical protein 0.002 0.0125 0.025
Schistosoma mansoni polycystin 1-related 0.002 0.0125 0.025
Loa Loa (eye worm) hypothetical protein 0.0022 0.0148 0.0378
Mycobacterium ulcerans monoamine oxidase 0.0022 0.0148 0.0616
Brugia malayi Doublecortin family protein 0.002 0.0125 0.0495
Loa Loa (eye worm) hypothetical protein 0.002 0.0125 0.0317
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0118 0.0115
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0092
Entamoeba histolytica aminopeptidase, putative 0.0012 0.0022 0.0617
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0022 0.0468
Schistosoma mansoni nuclear receptor 0.0013 0.0039 0.0078
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0022 0.0078
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0092
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0182 0.5135
Brugia malayi hypothetical protein 0.0013 0.0039 0.0148
Brugia malayi Protein kinase domain containing protein 0.0021 0.0135 0.0537
Brugia malayi TATA binding protein associated factor 0.0012 0.0022 0.0079
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0218 0.0696
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0118 0.023
Schistosoma mansoni lipoxygenase 0.002 0.0125 0.025
Onchocerca volvulus 0.0054 0.0529 0.18
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0125 0.0244
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0092
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0259 0.0256
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0351 0.0348
Echinococcus granulosus expressed protein 0.0035 0.0296 0.0587
Schistosoma mansoni ap endonuclease 0.0039 0.0351 0.0704
Brugia malayi hypothetical protein 0.0015 0.0058 0.0226
Mycobacterium ulcerans aldehyde dehydrogenase 0.0182 0.2076 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0022 0.0486
Brugia malayi hypothetical protein 0.0103 0.1115 0.4486
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0118 0.0341
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0039 0.0148
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0182 0.5202
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0039 0.0035
Brugia malayi hypothetical protein 0.0016 0.0075 0.0294
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0118 0.0115
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0182 0.4887
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0218 0.0215
Schistosoma mansoni slit 0.0023 0.0159 0.0319
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0265 0.3074 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.0142
Onchocerca volvulus 0.0013 0.0039 0.0061
Echinococcus granulosus bloom syndrome protein 0.0021 0.0126 0.0246
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0022 0.0148 0.0297
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0148 0.4226
Brugia malayi Cache domain containing protein 0.0058 0.0573 0.2302
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0125 0.0244
Schistosoma mansoni hypothetical protein 0.0423 0.4984 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0475 0.1229
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.0142
Brugia malayi nuclear receptor NHR-67 0.0013 0.0039 0.0148
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0022 0.0078
Entamoeba histolytica hypothetical protein 0.0036 0.0312 0.8902
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0259 0.052
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0118 0.0299
Brugia malayi PXA domain containing protein 0.002 0.0118 0.0468
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0126 0.0583
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0126 0.0123
Schistosoma mansoni amine oxidase 0.0022 0.0148 0.0297
Brugia malayi conserved hypotetical protein 0.0013 0.0039 0.0148
Onchocerca volvulus 0.0246 0.2843 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0296 0.1183
Schistosoma mansoni hypothetical protein 0.0067 0.0689 0.1383
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0022 0.0148 0.3846
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0256 0.2967 0.2965
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0039 0.0071
Toxoplasma gondii microneme protein MIC17C 0.0014 0.0045 0.0215
Loa Loa (eye worm) hypothetical protein 0.0053 0.0518 0.1341
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0182 0.2076 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0022 0.0148 0.4226
Loa Loa (eye worm) hypothetical protein 0.0022 0.0148 0.0378
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0092
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0218 0.056
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0039 0.0071
Entamoeba histolytica hypothetical protein 0.002 0.0118 0.3363
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0039 0.0071
Brugia malayi nuclear receptor NHR-88 0.0028 0.0218 0.0871
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0039 0.0035
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0.0039 0.0078
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0256 0.2967 0.5951
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0118 0.0115
Brugia malayi nuclear receptor RXR 0.0013 0.0039 0.0148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0218 0.0215
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0182 0.4887
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0218 0.0431
Onchocerca volvulus 0.0014 0.0045 0.0081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.0142
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0351 0.1603
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0118 0.0468
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0218 0.0437
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0218 0.0215
Leishmania major UDP-galactopyranose mutase 0.0022 0.0148 0.069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0182 0.2076 1
Brugia malayi hypothetical protein 0.0012 0.0022 0.0079
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0572 0.2753
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0118 0.0468
Brugia malayi PAN domain containing protein 0.0014 0.0045 0.0172
Brugia malayi PAN domain containing protein 0.0014 0.0045 0.0172
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0048
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0182 0.2076 1
Brugia malayi PAN domain containing protein 0.0014 0.0045 0.0172
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0039 0.0035
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0058 0.0142
Echinococcus granulosus intermediate filament protein 0.0054 0.0529 0.1056
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0118 0.0115
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0286 0.1377
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0118 0.0299
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0005 0.0137
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.0142
Onchocerca volvulus 0.0032 0.0259 0.0842
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0048
Echinococcus multilocularis tumor protein p63 0.0338 0.3951 0.3949
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0108
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0182 0.5135
Echinococcus multilocularis expressed protein 0.0386 0.4538 0.4536
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0045 0.0108
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0299
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0118 0.0299
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0045 0.0215
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0092
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0126 0.0607
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0022 0.0079
Brugia malayi hypothetical protein 0.002 0.0125 0.0495
Brugia malayi ecdysone receptor 0.0013 0.0039 0.0148
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0529 0.1372
Loa Loa (eye worm) hypothetical protein 0.002 0.0125 0.0317
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0126 0.032
Schistosoma mansoni hypothetical protein 0.0036 0.0312 0.0627
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0529 0.1372
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0014 0.0045 0.0215
Schistosoma mansoni rotamase 0.0035 0.0296 0.0593
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0223 0.2569 0.5154
Echinococcus multilocularis protoporphyrinogen oxidase 0.0022 0.0148 0.0145
Loa Loa (eye worm) aminopeptidase N 0.0012 0.0022 0.0048
Brugia malayi Pre-SET motif family protein 0.0216 0.2484 1
Schistosoma mansoni coup transcription factor 0.0028 0.0218 0.0437
Trypanosoma cruzi Aminopeptidase M1, putative 0.0012 0.0022 0.0486
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0039 0.0078
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0227 0.0584
Echinococcus multilocularis thyroid hormone receptor alpha 0.0284 0.3306 0.3304
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0.0039 0.0078
Loa Loa (eye worm) peptidase family M1 containing protein 0.0012 0.0022 0.0048
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0118 0.023
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0045 0.0215
Schistosoma mansoni regulator of G protein signaling 0.002 0.0118 0.0237
Loa Loa (eye worm) abnormal epIthelia family member 0.0023 0.0159 0.0406
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0039 0.0092
Onchocerca volvulus 0.0014 0.0045 0.0081
Echinococcus granulosus expressed protein 0.0386 0.4538 0.9104
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0045 0.0215
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0351 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0022 0.0148 0.0291
Loa Loa (eye worm) RecQ helicase 0.0021 0.0126 0.032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0092
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0218 0.0437
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0039 0.0071
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0218 0.0431
Schistosoma mansoni nuclear receptor 0.0013 0.0039 0.0078
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0118 0.0237
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0125 0.0244
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0118 0.0468
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0218 0.0437
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0039 0.0092
Toxoplasma gondii microneme protein MIC17A 0.0014 0.0045 0.0215
Echinococcus multilocularis aminopeptidase N 0.0012 0.0022 0.0018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0218 0.0431
Schistosoma mansoni intermediate filament proteins 0.0054 0.0529 0.1062
Onchocerca volvulus 0.0054 0.0529 0.18
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0259 0.052
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0135 0.0265
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0218 0.0696
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0118 0.023
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0351 1
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0125 0.1384 0.2776
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0351 0.0698
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.056
Toxoplasma gondii subtilisin SUB12 0.0014 0.0045 0.0215
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0218 0.0437
Trypanosoma cruzi UDP-galactopyranose mutase 0.0022 0.0148 0.4146
Plasmodium vivax SET domain protein, putative 0.0032 0.0259 0.7387
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0126 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0118 0.0341
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0351 0.1127
Echinococcus multilocularis 0.0022 0.0148 0.0145
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0118 0.0115
Schistosoma mansoni thyroid hormone receptor 0.0284 0.3306 0.6634
Echinococcus granulosus leukotriene A 4 hydrolase 0.0223 0.2569 0.5151
Toxoplasma gondii exonuclease III APE 0.0039 0.0351 0.169
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0475 0.0953
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0126 0.0246
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0126 0.0123
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0286 0.8147
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0135 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0259 0.052
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0092
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0022 0.0148 0.0616
Toxoplasma gondii aminopeptidase N, putative 0.0012 0.0022 0.0104
Echinococcus multilocularis expressed protein 0.0035 0.0296 0.0292
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0351 0.1406
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0218 0.0437
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0218 0.0437
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0218 0.0871
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0022 0.0037
Onchocerca volvulus 0.0028 0.0218 0.0696
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0135 0.0344
Echinococcus granulosus slit 2 protein 0.0023 0.0159 0.0312
Brugia malayi laminin alpha chain 0.0023 0.0159 0.0632
Onchocerca volvulus 0.0014 0.0045 0.0081
Echinococcus granulosus lamin 0.0054 0.0529 0.1056
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0218 0.0431
Brugia malayi laminin-like protein K08C7.3 precursor 0.0023 0.0159 0.0632
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0406
Echinococcus granulosus lysine specific histone demethylase 1A 0.0022 0.0148 0.0291
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0193 0.038
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0299
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0351 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0118 0.0237
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0218 0.056
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0108
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0223 0.2569 0.669
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0218 0.0871
Toxoplasma gondii hypothetical protein 0.0014 0.0045 0.0215
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0039 0.0078
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0022 0.0486
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0218 0.0437
Brugia malayi PXA domain containing protein 0.002 0.0118 0.0468
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0005 0.0019
Onchocerca volvulus 0.0014 0.0045 0.0081
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0108
Schistosoma mansoni cell polarity protein 0.0023 0.0159 0.0319
Onchocerca volvulus 0.0013 0.0039 0.0061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0218 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0218 0.0871
Schistosoma mansoni hypothetical protein 0.0011 0.0015 0.003
Onchocerca volvulus 0.002 0.0125 0.0366
Brugia malayi PAN domain containing protein 0.0014 0.0045 0.0172
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0092
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0223 0.2569 0.2566
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0118 0.0237
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0118 0.0468
Schistosoma mansoni regulator of G protein signaling 0.002 0.0118 0.0237
Entamoeba histolytica hypothetical protein 0.0036 0.0312 0.8902
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.056
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0218 0.0871
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0108
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0039 0.0035
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0022 0.0048
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0125 0.3558
Schistosoma mansoni regulator of G protein signaling 0.002 0.0118 0.0237
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0312 0.062
Schistosoma mansoni cpg binding protein 0.0031 0.0258 0.0517
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0148 0.3846
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0039 0.0071
Brugia malayi EGF-like domain containing protein 0.0023 0.0159 0.0632
Onchocerca volvulus 0.0022 0.0148 0.0449
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0237 0.061
Brugia malayi nuclear hormone receptor 0.0013 0.0039 0.0148
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0005 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0218 0.0871
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0063 0.0637 0.1279
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0182 0.0467
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0218 0.0437
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0022 0.0037
Schistosoma mansoni cpg binding protein 0.0031 0.0258 0.0517
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0118 0.0237
Brugia malayi ecdysteroid receptor 0.0028 0.0218 0.0871
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0259 0.052
Schistosoma mansoni regulator of G protein signaling 0.002 0.0118 0.0237
Brugia malayi hypothetical protein 0.0025 0.0182 0.0727
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0022 0.0486
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0015 0.0023
Brugia malayi hypothetical protein 0.0126 0.1398 0.5624
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0022 0.0037
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0351 1
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0118 0.0115
Brugia malayi PAN domain containing protein 0.0014 0.0045 0.0172
Loa Loa (eye worm) hypothetical protein 0.0022 0.0148 0.0378
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0135 0.3771
Brugia malayi CXXC zinc finger family protein 0.003 0.0237 0.0948
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0039 0.0148
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0092
Loa Loa (eye worm) doublecortin family protein 0.002 0.0125 0.0317
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0039 0.0061
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0126 0.037
Brugia malayi steroid hormone receptor 0.0028 0.0218 0.0871
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0022 0.0148 0.4226
Trichomonas vaginalis rotamase, putative 0.0035 0.0296 0.0971
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0406
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0126 0.3173
Mycobacterium ulcerans dehydrogenase 0.0022 0.0148 0.0616
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0022 0.0148 0.0297
Schistosoma mansoni hypothetical protein 0.0175 0.1994 0.4
Loa Loa (eye worm) hypothetical protein 0.0058 0.0573 0.1486
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0529 0.2125
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0148 0.4226
Echinococcus granulosus dnaJ subfamily B 0.0423 0.4984 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0218 0.0215
Toxoplasma gondii aldehyde dehydrogenase 0.0182 0.2076 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0108
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0039 0.0148
Onchocerca volvulus 0.0014 0.0045 0.0081
Echinococcus granulosus aminopeptidase N 0.0012 0.0022 0.0037
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0022 0.0486
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.0142
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0351 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0039 0.0071
Schistosoma mansoni axis inhibition protein axin 0.002 0.0118 0.0237
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0351 0.1167
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0182 0.0879
Echinococcus multilocularis RUN 0.002 0.0125 0.0122
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0135 0.3856
Entamoeba histolytica hypothetical protein 0.0036 0.0312 0.8902
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0218 0.0871
Onchocerca volvulus 0.0014 0.0045 0.0081
Schistosoma mansoni rab6-interacting 0.002 0.0125 0.025
Onchocerca volvulus 0.0014 0.0045 0.0081
Brugia malayi PAN domain containing protein 0.0014 0.0045 0.0172
Onchocerca volvulus 0.0014 0.0045 0.0081
Schistosoma mansoni axis inhibition protein axin 0.002 0.0118 0.0237
Onchocerca volvulus 0.002 0.0125 0.0366
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0218 0.056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0039 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0284 0.3306 0.6634
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0058 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0118 0.0341
Brugia malayi intermediate filament protein 0.0054 0.0529 0.2125
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0351 0.1668
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0022 0.0037
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0023 0.0159 0.0319
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0022 0.0018
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0118 0.023
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0118 0.0341
Echinococcus granulosus tumor protein p63 0.0338 0.3951 0.7926
Loa Loa (eye worm) hypothetical protein 0.0021 0.0126 0.032
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0022 0.0037
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0126 0.05
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0218 0.056
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0092
Echinococcus multilocularis lamin dm0 0.0054 0.0529 0.0526
Leishmania major hypothetical protein, conserved 0.0021 0.0135 0.0627
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0039 0.0061
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0218 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0218 0.0871
Brugia malayi PAN domain containing protein 0.0014 0.0045 0.0172
Loa Loa (eye worm) DR-78 0.0013 0.0039 0.0092
Echinococcus multilocularis cpg binding protein 0.0031 0.0258 0.0254
Brugia malayi hypothetical protein 0.0012 0.0022 0.0079
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0039 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0218 0.056
Echinococcus multilocularis lamin 0.0054 0.0529 0.0526
Echinococcus granulosus RUN 0.002 0.0125 0.0244
Schistosoma mansoni lipoxygenase 0.0057 0.0568 0.1139
Echinococcus granulosus lamin dm0 0.0054 0.0529 0.1056
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0218 0.0871
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0286 0.8121
Entamoeba histolytica hypothetical protein 0.0036 0.0312 0.8902
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0126 0.3493
Brugia malayi tailless protein 0.0013 0.0039 0.0148
Onchocerca volvulus 0.003 0.0237 0.0764
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0022 0.0148 0.0616
Echinococcus multilocularis neurogenic locus notch protein 0.0023 0.0159 0.0156
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0182 0.2076 0.2073
Schistosoma mansoni lamin 0.0054 0.0529 0.1062
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0045 0.0215
Schistosoma mansoni cpg binding protein 0.003 0.0237 0.0476
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0108
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0351 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0148 0.0378
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0039 0.0035
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0218 0.0437
Loa Loa (eye worm) hypothetical protein 0.0054 0.0529 0.1372
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0118 0.0115
Loa Loa (eye worm) hypothetical protein 0.0025 0.0181 0.0463
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0142 0.0362
Loa Loa (eye worm) hypothetical protein 0.0022 0.0148 0.0378
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0005 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0218 0.0431
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0045 0.0215
Toxoplasma gondii hypothetical protein 0.0014 0.0045 0.0215
Schistosoma mansoni serine-rich repeat protein 0.0067 0.0689 0.1383
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0126 0.05
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.056
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0039 0.0092
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.056
Brugia malayi amine oxidase, flavin-containing family protein 0.0022 0.0148 0.059
Schistosoma mansoni lamin 0.0054 0.0529 0.1062
Onchocerca volvulus 0.0014 0.0045 0.0081
Brugia malayi hypothetical protein 0.002 0.0118 0.0468
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0022 0.0468
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0045 0.0108
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0022 0.0148 0.0616
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0218 0.056
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0022 0.0018
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0118 0.023
Toxoplasma gondii PAN/Apple domain-containing protein 0.0014 0.0045 0.0215
Loa Loa (eye worm) RGS-3 protein 0.002 0.0118 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0118 0.0341
Echinococcus granulosus cpg binding protein 0.0031 0.0258 0.0511
Entamoeba histolytica recQ family DNA helicase 0.001 0.0005 0.0137
Echinococcus granulosus voltage dependent calcium channel subunit 0.0286 0.3329 0.6676
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0022 0.0617
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0118 0.0341
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0126 0.0246
Echinococcus granulosus axis inhibition protein axin 0.002 0.0118 0.023
Leishmania major hypothetical protein, conserved 0.0025 0.0182 0.0855
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0057 0.0115
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0218 0.0871
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0218 0.0431
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0299
Loa Loa (eye worm) hypothetical protein 0.0022 0.0148 0.0378
Schistosoma mansoni regulator of G protein signaling 0.002 0.0118 0.0237
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0126 0.05
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0125 0.0122
Echinococcus granulosus geminin 0.0175 0.1994 0.3996
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0126 0.037
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0022 0.0468
Chlamydia trachomatis protoporphyrinogen oxidase 0.0022 0.0148 0.5
Trichomonas vaginalis set domain proteins, putative 0.0246 0.2843 1
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0005 0.0026
Toxoplasma gondii aminopeptidase n, putative 0.0012 0.0022 0.0104
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0092
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0218 0.0696
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0296 0.0971
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0218 0.0871
Onchocerca volvulus 0.0014 0.0045 0.0081
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0227 0.0908
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0118 0.0341
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.056
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0058 0.0116
Echinococcus multilocularis pikachurin 0.0023 0.0159 0.0156
Brugia malayi Kringle domain containing protein 0.0021 0.0135 0.0537
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0022 0.0018
Brugia malayi nuclear receptor RXR 0.0015 0.0058 0.0226
Mycobacterium ulcerans aldehyde dehydrogenase 0.0182 0.2076 1
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0045 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0218 0.056
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.056
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0218 0.0215
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0012 0.0022 0.0043
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0299
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0048
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0118 0.0115
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0218 0.0871
Schistosoma mansoni aminopeptidase A (M01 family) 0.0012 0.0022 0.0043
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0118 0.023
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0286 0.8118
Mycobacterium ulcerans oxidoreductase 0.0022 0.0148 0.0616
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0312 0.0309
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0218 0.0215
Schistosoma mansoni rab6-interacting 0.002 0.0125 0.025
Brugia malayi Pre-SET motif family protein 0.0032 0.0259 0.1036
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0058 0.011
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0125 0.0122
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.056
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0126 0.3173
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0218 0.0437
Trypanosoma brucei aminopeptidase, putative 0.0012 0.0022 0.0468
Toxoplasma gondii microneme protein, putative 0.0014 0.0045 0.0215
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0182 0.2076 0.4161
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0118 0.0237
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0118 0.0468
Schistosoma mansoni DNA helicase recq5 0.0021 0.0126 0.0253
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0118 0.0468
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0299
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0058 0.0226
Brugia malayi hypothetical protein 0.0036 0.0312 0.125
Entamoeba histolytica hypothetical protein 0.002 0.0118 0.3363
Brugia malayi hypothetical protein 0.002 0.0118 0.0468
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0351 0.1051
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0126 0.037
Toxoplasma gondii microneme protein MIC4 0.0014 0.0045 0.0215
Loa Loa (eye worm) hypothetical protein 0.0023 0.0159 0.0406
Schistosoma mansoni hypothetical protein 0.0021 0.0135 0.0271
Schistosoma mansoni DNA helicase recq1 0.0021 0.0126 0.0253
Plasmodium falciparum protoporphyrinogen oxidase 0.0022 0.0148 0.3846
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0022 0.0078
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0344
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0045 0.0108
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0568 0.0565
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0351 0.0906
Brugia malayi PAN domain containing protein 0.0014 0.0045 0.0172
Schistosoma mansoni amine oxidase 0.0022 0.0148 0.0297
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0259 0.1248
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0125 0.3134
Schistosoma mansoni aldehyde dehydrogenase 0.0182 0.2076 0.4165
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0568 0.1133
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0259 0.0256
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0312 0.0627
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0012 0.0022 0.0018
Echinococcus multilocularis geminin 0.0175 0.1994 0.1991
Trichomonas vaginalis rotamase, putative 0.0034 0.0286 0.0936
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0024 0.017 0.0819
Toxoplasma gondii histone lysine-specific demethylase 0.0022 0.0148 0.0714
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0058 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0218 0.0871
Echinococcus multilocularis slit 2 protein 0.0023 0.0159 0.0156
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0299
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.056
Brugia malayi hypothetical protein 0.0015 0.0058 0.0226
Brugia malayi PAN domain containing protein 0.0014 0.0045 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0218 0.0871
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0058 0.0055
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0022 0.0617
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0108
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0125 0.0122
Brugia malayi SWIRM domain containing protein 0.0022 0.0148 0.059
Entamoeba histolytica hypothetical protein 0.002 0.0118 0.3363
Brugia malayi PAN domain containing protein 0.0014 0.0045 0.0172
Schistosoma mansoni zinc finger protein 0.0013 0.0039 0.0078
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0118 0.0237
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0022 0.0018
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0135 0.3453

Activities

Activity type Activity value Assay description Source Reference
Ratio (functional) 1.3 MRP1 antagonism was determined percentage of MCF-7/VP cells surviving in the absence of vincristine/percentage of MCF-7/VP cells survivingin the presence of vincristine ChEMBL. 14998330
Ratio (functional) = 4.2 Pgp antagonism was determined percentage of NCI/ADR cells surviving in the absence of vinblastine/percentage of NCI/ADR cells surviving in the presence of vinblastine ChEMBL. 14998330
Ratio (functional) 1.3 MRP1 antagonism was determined percentage of MCF-7/VP cells surviving in the absence of vincristine/percentage of MCF-7/VP cells survivingin the presence of vincristine ChEMBL. 14998330
Ratio (functional) 3.2 Ratio of the Pgp to that of MRP1 was determined ChEMBL. 14998330
Ratio (functional) = 4.2 Pgp antagonism was determined percentage of NCI/ADR cells surviving in the absence of vinblastine/percentage of NCI/ADR cells surviving in the presence of vinblastine ChEMBL. 14998330
Toxicity (ADMET) = 50 % Toxicity was determined against of MCF-7 cells at a dose of 10 ug/mL ChEMBL. 14998330
Toxicity (ADMET) = 50 % Toxicity was determined against of MCF-7 cells at a dose of 10 ug/mL ChEMBL. 14998330

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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