Detailed information for compound 429755

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 629.724 | Formula: C34H40FN7O4
  • H donors: 2 H acceptors: 2 LogP: 3.96 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(OC)ccc1N(C(c1nc2ccccc2c(=O)n1N1CCN(CC1)C[C@@H]1CCCN1)C)C(=O)Nc1ccc(cc1)F
  • InChi: 1S/C34H40FN7O4/c1-23(41(30-15-14-27(45-2)21-31(30)46-3)34(44)37-25-12-10-24(35)11-13-25)32-38-29-9-5-4-8-28(29)33(43)42(32)40-19-17-39(18-20-40)22-26-7-6-16-36-26/h4-5,8-15,21,23,26,36H,6-7,16-20,22H2,1-3H3,(H,37,44)/t23?,26-/m0/s1
  • InChiKey: YNDGWPZAPRMASI-NASUQTAISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0026 0.0201 0.0727
Echinococcus granulosus tar DNA binding protein 0.0062 0.0742 0.0723
Onchocerca volvulus 0.0431 0.6349 1
Echinococcus multilocularis methionine synthase reductase 0.0016 0.005 0.003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0247 0.0228
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0068 0.0076
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0048 0.0039
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0031 0.0271 0.1609
Trypanosoma cruzi p450 reductase, putative 0.0026 0.0201 0.3599
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0068 0.0048
Plasmodium falciparum geranylgeranyltransferase, putative 0.0031 0.0271 0.104
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0335 0.5841
Schistosoma mansoni NADPH flavin oxidoreductase 0.0013 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0076
Trichomonas vaginalis pc-MYB2, putative 0.0019 0.0092 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0068 0.0076
Toxoplasma gondii hypothetical protein 0.0042 0.0443 0.0716
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0052 0.0032
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0068 0.0065
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0271 0.0738
Leishmania major DNA polymerase kappa, putative 0.002 0.0118 0.1673
Echinococcus multilocularis Ankyrin 0.0032 0.0287 0.0267
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0042 0.0443 0.1262
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0443 0.7838
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.14 0.8858
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0052 0.0032
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0195 0.0276
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Loa Loa (eye worm) RNA binding protein 0.0062 0.0742 0.1141
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Giardia lamblia Rab geranylgeranyltransferase 0.0031 0.0271 0.1005
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0031 0.0271 0.0436
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0559 0.0557
Loa Loa (eye worm) hypothetical protein 0.0161 0.226 0.354
Brugia malayi Smad1 0.0016 0.0052 0.0051
Echinococcus granulosus nuclear factor of activated T cells 5 0.0301 0.4375 0.4364
Brugia malayi polk-prov protein 0.003 0.0266 0.0388
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0703 0.7357
Brugia malayi hypothetical protein 0.0099 0.1315 0.2047
Brugia malayi Peroxidasin 0.0026 0.0195 0.0276
Brugia malayi Cytochrome P450 family protein 0.0019 0.0092 0.0115
Schistosoma mansoni lamin 0.0026 0.0205 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0203 0.0531
Trypanosoma cruzi metacaspase 5, putative 0.0017 0.0068 0.1213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.047 0.1347
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.002 0.0362
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0048 0.0524
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.047 0.0451
Brugia malayi Cytochrome P450 family protein 0.0019 0.0092 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.03 0.0827
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0703 0.1139
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0087 0.1134 0.1116
Trypanosoma cruzi metacaspase, putative 0.0017 0.0068 0.1213
Schistosoma mansoni hypothetical protein 0.0015 0.0039 0.0037
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0443 0.7916
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0195 0.0276
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.004 0.0061
Echinococcus granulosus smad 0.0016 0.0052 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0068 0.0118
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0026 0.0201 0.2861
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0559 0.1618
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0026 0.0201 0.3359
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0031 0.0271 0.104
Leishmania major p450 reductase, putative 0.0026 0.0201 0.2861
Schistosoma mansoni intermediate filament proteins 0.0026 0.0205 0.0203
Loa Loa (eye worm) hypothetical protein 0.0029 0.0247 0.036
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0335 0.4763
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0048 0.0046
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0543 0.0826
Echinococcus multilocularis lamin dm0 0.0026 0.0205 0.0185
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0026 0.0201 0.3599
Loa Loa (eye worm) hypothetical protein 0.0026 0.0205 0.0292
Schistosoma mansoni hypothetical protein 0.0015 0.0039 0.0037
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0201 0.2863 0.2849
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0068 0.0126
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0161 0.226 0.2245
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.031 0.0458
Toxoplasma gondii hypothetical protein 0.0163 0.2288 0.3714
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0867
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.047 0.0451
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0703 0.7357
Brugia malayi follicle stimulating hormone receptor 0.0225 0.3228 0.5068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0165 0.0415
Plasmodium vivax geranylgeranyltransferase, putative 0.0031 0.0271 0.104
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0559 1
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0338 0.0319
Schistosoma mansoni cytochrome P450 reductase 0.0026 0.0201 0.0199
Brugia malayi Death domain containing protein 0.0031 0.0274 0.0401
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.004 0.0566
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0048 0.0039
Loa Loa (eye worm) hypothetical protein 0.0431 0.6349 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0068 0.0076
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0068 0.0065
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0201 0.2863 0.2862
Loa Loa (eye worm) hypothetical protein 0.0026 0.0198 0.0281
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0048 0.0028
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0042 0.0443 0.1814
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.341 0.5357
Echinococcus multilocularis caspase 2 0.0057 0.0676 0.0657
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0042 0.0443 0.0668
Loa Loa (eye worm) FAD binding domain-containing protein 0.0026 0.0201 0.0287
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0537 0.0535
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0505 0.0486
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0017 0.0068 0.0048
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0163 0.2288 0.3583
Trypanosoma brucei unspecified product 0.0034 0.0316 0.5481
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0104 0.0133
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0031 0.0271 0.0738
Brugia malayi MH2 domain containing protein 0.0016 0.0052 0.0051
Echinococcus granulosus lamin dm0 0.0026 0.0205 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0334 0.0932
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.1134 0.1132
Schistosoma mansoni smad1 5 8 and 0.0016 0.0052 0.005
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0087 0.1134 0.1116
Brugia malayi Protein kinase domain containing protein 0.0031 0.028 0.0412
Brugia malayi Uncoordinated protein 44 0.0031 0.0274 0.0401
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0092 0.0191
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0048 0.0867
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.012 0.1624 0.4868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0165 0.0415
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.047 0.0712
Echinococcus multilocularis lamin 0.0026 0.0205 0.0185
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0029 0.0164
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0042 0.0443 0.0423
Loa Loa (eye worm) runx1 0.0054 0.0627 0.096
Schistosoma mansoni single-minded 0.0047 0.0525 0.0523
Echinococcus granulosus geminin 0.0165 0.2309 0.2294
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0048 0.0524
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0415 0.0396
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0443 0.7916
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0104 0.0539
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.004 0.0712
Onchocerca volvulus Cell death protein 3 homolog 0.0057 0.0676 0.0969
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0201 0.2863 0.2849
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0274 0.0254
Brugia malayi hypoxia-induced factor 1 0.0146 0.203 0.3177
Echinococcus multilocularis smad 0.0016 0.0052 0.0032
Plasmodium falciparum nitric oxide synthase, putative 0.0026 0.0201 0.0727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0164 0.0413
Echinococcus granulosus intermediate filament protein 0.0026 0.0205 0.0185
Toxoplasma gondii endonuclease IV APN 0.0074 0.0939 0.1522
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0201 0.2863 0.4492
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0048 0.0059
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0039 0.0031
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1578 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0266 0.4553
Onchocerca volvulus 0.0026 0.0195 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0334 0.0932
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0092 0.1652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0203 0.0531
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.012 0.1858
Trypanosoma cruzi metacaspase, putative 0.0017 0.0068 0.1213
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0092 0.0252
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0029 0.0015
Treponema pallidum NADH oxidase 0.0016 0.0048 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0068 0.0048
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0048 0.0045
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0703 0.0701
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0413 0.7289
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0161 0.226 0.681
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.047 0.8411
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0068 0.0065
Loa Loa (eye worm) STAT protein 0.0128 0.1749 0.2732
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0092 0.1652
Brugia malayi Zinc finger, C2H2 type family protein 0.0344 0.5037 0.7927
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0017 0.0068 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0413 0.7387
Brugia malayi Blistered cuticle protein 3 0.0026 0.0195 0.0276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0068 0.0076
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0271 0.0738
Brugia malayi RNA binding protein 0.0062 0.0742 0.1141
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0559 0.054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.03 0.0827
Brugia malayi STAT protein, DNA binding domain containing protein 0.0128 0.1749 0.2732
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0559 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0505 0.903
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0048 0.0181
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0068 0.0076
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.004 0.002
Trypanosoma brucei Metacaspase-4 0.0017 0.0068 0.0883
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0413 0.7289
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.002 0.0001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0068 0.0118
Entamoeba histolytica hypothetical protein 0.0035 0.0338 0.1117
Echinococcus multilocularis caspase 0.0017 0.0068 0.0048
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2881 0.452
Brugia malayi hypothetical protein 0.0159 0.2217 0.3472
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0031 0.0271 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0068 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0118 0.1808
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0195 0.0276
Brugia malayi FAD binding domain containing protein 0.0026 0.0201 0.0287
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0742 0.074
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0048 0.5
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0042 0.0443 0.1486
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0068 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0068 0.0076
Leishmania major geranylgeranyltransferase, putative 0.0031 0.0271 0.385
Loa Loa (eye worm) hypothetical protein 0.0074 0.0939 0.1452
Loa Loa (eye worm) hypothetical protein 0.0098 0.1302 0.2026
Mycobacterium tuberculosis Probable reductase 0.0105 0.14 0.8858
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0029 0.0015
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0689
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0068 0.0065
Schistosoma mansoni caspase-3 (C14 family) 0.0017 0.0068 0.0065
Plasmodium vivax glutathione reductase, putative 0.0046 0.0505 0.2095
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.004 0.002
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0559 1
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0271 0.0738
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0048 0.0524
Giardia lamblia Rab geranylgeranyltransferase 0.0042 0.0443 0.1782
Brugia malayi MH2 domain containing protein 0.0237 0.341 0.5357
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.047 0.6686
Onchocerca volvulus Peroxidase homolog 0.0026 0.0195 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0413 0.7289
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0048 0.0059
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0026 0.0201 0.3599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0164 0.0413
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.004 0.0126
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0092 0.0191
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.004 0.0061
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0559 0.0905
Echinococcus granulosus caspase 0.0017 0.0068 0.0048
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.14 0.8793
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0413 0.7289
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1578 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0274 0.0401
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0048 0.0689
Loa Loa (eye worm) hypothetical protein 0.0031 0.0274 0.0401
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0413 0.4095
Schistosoma mansoni smad 0.0016 0.0052 0.005
Chlamydia trachomatis endonuclease IV 0.0074 0.0939 1
Echinococcus multilocularis tumor protein p63 0.0328 0.4798 0.4787
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0867
Onchocerca volvulus 0.0098 0.1302 0.1966
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0443 0.7916
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0068 0.0048
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0161 0.226 0.681
Onchocerca volvulus 0.0098 0.1302 0.1966
Trichomonas vaginalis sulfite reductase, putative 0.0026 0.0201 0.0526
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0161 0.226 0.2245
Plasmodium falciparum thioredoxin reductase 0.0046 0.0505 0.2095
Toxoplasma gondii hypothetical protein 0.012 0.1624 0.2636
Entamoeba histolytica hypothetical protein 0.0035 0.0338 0.1117
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0074 0.0939 0.1452
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0093 0.0196
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0443 0.7838
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0742 0.074
Schistosoma mansoni hypothetical protein 0.0165 0.2309 0.2308
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0031 0.0271 0.104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0068 0.0076
Onchocerca volvulus Transcription factor Sp5 homolog 0.0344 0.5037 0.7911
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0026 0.0201 0.3359
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0076
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.341 0.5357
Echinococcus multilocularis Protein lozenge 0.0054 0.0627 0.0608
Loa Loa (eye worm) hypothetical protein 0.0119 0.1616 0.2522
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0042 0.0443 0.0668
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0068 0.0076
Loa Loa (eye worm) hypothetical protein 0.0048 0.0537 0.0817
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0559 0.0852
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.002 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0559 0.1618
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0068 0.0076
Schistosoma mansoni peroxidasin 0.0026 0.0195 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.03 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.03 0.0827
Loa Loa (eye worm) glutathione reductase 0.0046 0.0505 0.0766
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0195 0.0202
Trichomonas vaginalis MYB72, putative 0.0019 0.0092 0.0191
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0026 0.0201 0.0181
Trichomonas vaginalis pc-MYB2, putative 0.0019 0.0092 0.0191
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.14 0.8858
Trypanosoma cruzi metacaspase, putative 0.0017 0.0068 0.1213
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0068 0.0118
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.1134 0.1132
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0048 0.0075
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0195 0.0202
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0068 0.0048
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0118 0.1673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.047 0.1347
Loa Loa (eye worm) FAD binding domain-containing protein 0.0016 0.005 0.0048
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0031 0.0271 0.0269
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0042 0.0443 0.1814
Brugia malayi M-phase phosphoprotein, mpp8 0.0098 0.1302 0.2026
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0068 0.0065
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0068 0.0048
Brugia malayi flavodoxin family protein 0.0026 0.0201 0.0287
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.203 0.3177
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0026 0.0201 0.0181
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0559 0.1618
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.0443 0.7916
Leishmania major metacaspase, putative 0.0017 0.0068 0.0964
Giardia lamblia DINP protein human, muc B family 0.002 0.0118 0.0313
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0195 0.0202
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0163 0.2288 0.3583
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0068 0.0065
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0161 0.226 0.2258
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0068 0.0076
Mycobacterium ulcerans endonuclease IV 0.0074 0.0939 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.002 0.0018
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0042 0.0443 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.03 0.0827
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0042 0.0443 0.0423
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0051 0.0577
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.14 0.8858
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0029 0.052
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0039 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0742 0.074
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0413 0.4095
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0247 0.0398
Onchocerca volvulus 0.004 0.0415 0.0553
Loa Loa (eye worm) hypothetical protein 0.0099 0.1315 0.2047
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0031 0.0271 0.0251
Loa Loa (eye worm) hypothetical protein 0.0057 0.0676 0.1037
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0017 0.0068 0.0076
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0237 0.0636
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0413 0.7387
Giardia lamblia Nitric oxide synthase, inducible 0.0023 0.0156 0.0488
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0031 0.0271 0.0738
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0201 0.2863 0.865
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.047 0.8351
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0052 0.0051
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0068 0.0048
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0338 0.0336
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0195 0.0276
Onchocerca volvulus 0.0042 0.0443 0.0597
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0029 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0703 0.7357
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0161 0.226 0.354
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.047 0.8411
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0092 0.0191
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0031 0.0271 0.0881
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0068 0.0048
Loa Loa (eye worm) hypothetical protein 0.0159 0.2217 0.3472
Schistosoma mansoni caspase-7 (C14 family) 0.0017 0.0068 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0051 0.0577
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0092 0.0252
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1578 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0247 0.0245
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0092 0.0493
Trypanosoma brucei lanosterol synthase 0.0031 0.0271 0.465
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0029 0.0164
Brugia malayi glutathione reductase 0.0046 0.0505 0.0766
Plasmodium vivax flavodoxin domain containing protein 0.0023 0.0156 0.0525
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0068 0.0118
Loa Loa (eye worm) hypothetical protein 0.0048 0.0543 0.0826
Brugia malayi MH1 domain containing protein 0.0016 0.0052 0.0051
Echinococcus granulosus lamin 0.0026 0.0205 0.0185
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0271 0.4843
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0031 0.0271 0.465
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0068 0.0076
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0076
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Loa Loa (eye worm) hypothetical protein 0.003 0.0266 0.0388
Trypanosoma brucei metacaspase 0.0017 0.0068 0.0883
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0029 0.0413
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.004 0.0037
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0068 0.0048
Leishmania major cytochrome p450-like protein 0.0019 0.0092 0.1313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0068 0.0076
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0076
Echinococcus multilocularis geminin 0.0165 0.2309 0.2294
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0026 0.0201 0.3359
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0205 0.0292
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.004 0.002
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0052 0.0032
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.0443 0.7916
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0195 0.0276
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0338 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0165 0.0415
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0052 0.005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0338 0.0318
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0335 0.5991
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0274 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0334 0.0932
Schistosoma mansoni peroxidasin 0.0026 0.0195 0.0192
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0031 0.0271 0.0738
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0161 0.226 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0032 0.0287 0.0284
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0048 0.0524
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0104 0.0626
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0703 0.0685
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0039 0.0019
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0689
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0039 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0068 0.0076
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.004 0.0712
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0559 0.054
Schistosoma mansoni hypothetical protein 0.0015 0.0039 0.0037
Giardia lamblia Hypothetical protein 0.0023 0.0156 0.0488
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0413 0.7289
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0559 0.2309
Echinococcus multilocularis GPCR, family 2 0.0015 0.0039 0.0019
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0023 0.0156 0.0389
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0274 0.0254
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0104 0.0058
Onchocerca volvulus 0.0026 0.0195 0.0202
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0195 0.0276
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.002 0.0001
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0092 0.0191
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.047 0.0712
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0068 0.0048
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Brugia malayi hypothetical protein 0.0035 0.0338 0.0502
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0042 0.0443 0.6293
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0505 0.3112
Onchocerca volvulus 0.0048 0.0537 0.0747
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0031 0.0271 0.104
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0505 0.0766
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0068 0.0076
Trypanosoma cruzi metacaspase 5, putative 0.0017 0.0068 0.1213
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0068 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0247 0.0245
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0205 0.0292
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0031 0.0271 0.0251
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0231 0.0211
Brugia malayi steroid hormone receptor 0.0017 0.0068 0.0076
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0048 0.0039
Onchocerca volvulus Huntingtin homolog 0.0119 0.1616 0.2465
Brugia malayi Isocitrate dehydrogenase 0.0015 0.004 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0203 0.0531
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0559 0.054
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0068 0.0048
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0195 0.0276
Brugia malayi Pre-SET motif family protein 0.0202 0.2881 0.452
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0274 0.0254
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0031 0.0271 0.0397
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0042 0.0443 0.7838
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.0939 0.4048
Echinococcus granulosus tumor protein p63 0.0328 0.4798 0.4787
Onchocerca volvulus 0.0026 0.0205 0.0218
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0056 0.0656 0.0654
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0316 0.5481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0373 0.105
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0161 0.226 0.354
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0068 0.0065
Plasmodium falciparum metacaspase-like protein 0.0017 0.0068 0.0126
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.004 0.002
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0703 1
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0201 0.2863 0.2862
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0074 0.0939 0.5664
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0161 0.226 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0068 0.0106
Giardia lamblia Prenyltransferase 0.0031 0.0271 0.1005
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0742 0.074
Echinococcus multilocularis musashi 0.0026 0.0205 0.0185
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0867
Loa Loa (eye worm) hypothetical protein 0.0026 0.0201 0.0287
Brugia malayi hypothetical protein 0.0431 0.6349 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.004 0.0415 0.0624
Plasmodium falciparum metacaspase 1 0.0017 0.0068 0.0126
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.047 0.0468
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0559 0.7949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.03 0.0827
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0017 0.0068 0.0065
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0068 0.0118
Brugia malayi Pre-SET motif family protein 0.0029 0.0247 0.036
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0195 0.0276
Brugia malayi FAD binding domain containing protein 0.0016 0.005 0.0048
Schistosoma mansoni Smad4 0.0016 0.0052 0.005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0039 0.0031
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0068 0.0118
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0068 0.0118
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0247 0.0228
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0505 0.2095
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.004 0.0363
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0092 0.0115
Loa Loa (eye worm) Smad1 0.0016 0.0052 0.0051
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0703 0.0685
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0274 0.0401
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0195 0.0276
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0093 0.0196
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0543 0.0826
Schistosoma mansoni caspase-7 (C14 family) 0.0057 0.0676 0.0674
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0016 0.005 0.0048
Leishmania major farnesyltransferase beta subunit 0.0031 0.0271 0.385
Loa Loa (eye worm) hypothetical protein 0.0033 0.031 0.0458
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.0939 0.4048
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0161 0.226 0.7879
Trichomonas vaginalis C-MYB, putative 0.0019 0.0092 0.0191
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0076
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0092 0.0191
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.047 0.6686
Trichomonas vaginalis MYB, putative 0.0019 0.0093 0.0196
Mycobacterium ulcerans epimerase 0.002 0.0104 0.0626
Onchocerca volvulus 0.0026 0.0195 0.0202
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0092 0.0252
Schistosoma mansoni netrin receptor unc5 0.0031 0.0274 0.0271
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0195 0.0202
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0031 0.0271 0.0251
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0052 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0165 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0068 0.0076
Brugia malayi TAR-binding protein 0.0062 0.0742 0.1141
Onchocerca volvulus Peroxidase homolog 0.0026 0.0195 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0068 0.0076
Trypanosoma cruzi lanosterol synthase, putative 0.0031 0.0271 0.4843
Brugia malayi hypothetical protein 0.004 0.0415 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.03 0.0827
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0247 0.0228
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0068 0.0076
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0205 0.0292
Plasmodium vivax metacaspase 1, putative 0.0017 0.0068 0.0126
Trypanosoma brucei metacaspase MCA2 0.0017 0.0068 0.0883
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0031 0.0271 0.0738
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0026 0.0201 0.3599
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0068 0.0106
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0092 0.0252
Trichomonas vaginalis C-MYB, putative 0.0019 0.0092 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0051 0.0577
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0413 0.1172
Echinococcus granulosus GPCR family 2 0.0015 0.0039 0.0019
Plasmodium falciparum glutathione reductase 0.0046 0.0505 0.2095
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.004 0.002
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0068 0.0048
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0029 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0252 0.068
Schistosoma mansoni smad1 5 8 and 0.0016 0.0052 0.005
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0271 0.0436
Schistosoma mansoni hypothetical protein 0.0035 0.0338 0.0336
Brugia malayi nuclear receptor NHR-88 0.0017 0.0068 0.0076
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0118 0.0626
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0076
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0068 0.0065
Brugia malayi PAS domain containing protein 0.0047 0.0525 0.0798
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0068 0.0048
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0068 0.0118
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0042 0.0443 0.0423
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0048 0.0867
Giardia lamblia GTOR 0.0044 0.047 0.1907
Chlamydia trachomatis sulfite reductase 0.0016 0.005 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0068 0.0118
Trypanosoma cruzi protein farnesyltransferase, putative 0.0031 0.0271 0.4843
Brugia malayi ecdysteroid receptor 0.0017 0.0068 0.0076
Onchocerca volvulus 0.0231 0.3318 0.5175
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0274 0.0328
Echinococcus granulosus caspase 8 0.0017 0.0068 0.0048
Echinococcus multilocularis dna polymerase kappa 0.004 0.0413 0.0394
Loa Loa (eye worm) hypothetical protein 0.0015 0.0039 0.0031
Schistosoma mansoni hypothetical protein 0.004 0.0415 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.047 0.1347
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0031 0.0271 0.0269
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.047 0.1583
Toxoplasma gondii thioredoxin reductase 0.0046 0.0505 0.0817
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0068 0.0118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0867
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.004 0.0032
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0026 0.0201 0.1716
Echinococcus multilocularis caspase 8 0.0017 0.0068 0.0048
Loa Loa (eye worm) SPTF-3 protein 0.0344 0.5037 0.7927
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0525 0.0523
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0068 0.0118
Trypanosoma cruzi protein farnesyltransferase, putative 0.0031 0.0271 0.4843
Echinococcus granulosus death domain containing protein 0.0031 0.0274 0.0254
Trypanosoma brucei protein kinase, putative 0.005 0.0559 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0413 0.7289
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0418 0.6155 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0068 0.0048
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0048 0.0867
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0031 0.0271 0.0397
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.0397
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0703 0.0701
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Onchocerca volvulus Huntingtin homolog 0.0119 0.1616 0.2465
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0559 0.054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0867
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0068 0.0118
Plasmodium vivax SET domain protein, putative 0.0029 0.0247 0.0935
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0274 0.0254
Loa Loa (eye worm) hypothetical protein 0.0431 0.6349 1
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0031 0.0271 0.104
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0068 0.0048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0048 0.0867
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0199 0.0519
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.14 0.8858
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0201 0.2863 0.4492
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0559 0.7949
Echinococcus multilocularis Smad4 0.0016 0.0052 0.0032
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Schistosoma mansoni DNA polymerase eta 0.0014 0.002 0.0018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0068 0.0048
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0068 0.0076
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0031 0.0271 0.0397
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0026 0.0201 0.0181
Schistosoma mansoni hypothetical protein 0.0015 0.0039 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0413 0.7387
Plasmodium falciparum glutathione reductase 0.0016 0.0048 0.0039
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0161 0.226 0.681
Brugia malayi isocitrate dehydrogenase 0.0015 0.004 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0164 0.0413
Echinococcus granulosus peroxidasin 0.0026 0.0195 0.0175
Giardia lamblia Myb 1-like protein 0.0019 0.0093 0.0202
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0026 0.0201 0.3359
Echinococcus granulosus dna polymerase kappa 0.004 0.0413 0.0394
Entamoeba histolytica hypothetical protein 0.0035 0.0338 0.1117
Loa Loa (eye worm) hypothetical protein 0.0119 0.1616 0.2522
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0068 0.0048
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0742 0.1141
Loa Loa (eye worm) hypothetical protein 0.0032 0.0287 0.0422
Onchocerca volvulus 0.0026 0.0205 0.0218
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0076
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.0397
Brugia malayi intermediate filament protein 0.0026 0.0205 0.0292
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0443 0.7838
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0413 0.7289
Loa Loa (eye worm) hypothetical protein 0.0026 0.0195 0.0276
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0742 0.074
Leishmania major trypanothione reductase 0.0046 0.0505 0.7178
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0505 0.0486
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0068 0.0065
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.3228 0.5068
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.03 0.0484
Leishmania major cytochrome P450 reductase, putative 0.0023 0.0156 0.2223
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.047 0.8351
Onchocerca volvulus 0.0035 0.0338 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0068 0.0076
Trypanosoma cruzi lanosterol synthase, putative 0.0031 0.0271 0.4843
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0416 0.0414
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.0092 0.0252
Leishmania major DNA polymerase eta, putative 0.0014 0.002 0.0288
Loa Loa (eye worm) hypothetical protein 0.0163 0.2288 0.3583
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0076
Schistosoma mansoni hypothetical protein 0.0033 0.031 0.0308
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0543 0.0826
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0068 0.0065
Trichomonas vaginalis MYB3r3, putative 0.0019 0.0092 0.0191
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0039 0.0019
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0092 0.0115
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0052 0.0051
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0703 0.4387
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0031 0.0271 0.0738
Echinococcus granulosus single minded 2 0.0035 0.0338 0.0319
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0048 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0199 0.0519
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0019 0.0093 0.0147
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0415 0.0396
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0559 1
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0271 0.465
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0559 0.1618
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.004 0.002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0338 0.0318
Trypanosoma brucei metacaspase 5, putative 0.0017 0.0068 0.0883
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0413 0.7289
Echinococcus multilocularis microtubule associated protein 2 0.0671 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0068 0.0048
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0031 0.0271 0.0881
Trypanosoma brucei metacaspase MCA3 0.0017 0.0068 0.0883
Schistosoma mansoni microtubule-associated protein tau 0.0671 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0271 0.4843
Schistosoma mansoni coup transcription factor 0.0017 0.0068 0.0065
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0413 0.7387
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0048 0.0689
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0195 0.0276
Echinococcus granulosus Smad4 0.0016 0.0052 0.0032
Trypanosoma brucei trypanothione reductase 0.0046 0.0505 0.8994
Brugia malayi MH1 domain containing protein 0.0016 0.0052 0.0051
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0201 0.2863 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0092 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0271 0.4843
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0413 0.7289
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0559 1
Brugia malayi nuclear hormone receptor 0.0017 0.0068 0.0076
Trichomonas vaginalis set domain proteins, putative 0.023 0.3305 1
Brugia malayi MH2 domain containing protein 0.0016 0.0052 0.0051
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0048 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0068 0.0118
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0048 0.0075
Schistosoma mansoni smad1 5 8 and 0.0016 0.0052 0.005
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0092 0.1338
Schistosoma mansoni lozenge 0.0054 0.0627 0.0625
Entamoeba histolytica hypothetical protein 0.0035 0.0338 0.1117
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.047 0.1583
Loa Loa (eye worm) hypothetical protein 0.0163 0.2288 0.3583
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.004 0.0363
Brugia malayi hypothetical protein 0.0119 0.1616 0.2522
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0742 0.1141
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0029 0.0009
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0068 0.0118
Giardia lamblia Rab geranylgeranyltransferase 0.0161 0.226 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0048 0.0039
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.14 0.8858
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0742 0.0723
Mycobacterium ulcerans hypothetical protein 0.002 0.0104 0.0626
Brugia malayi Cell death protein 3 precursor 0.0057 0.0676 0.1037
Brugia malayi hypothetical protein 0.0026 0.0195 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0068 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0413 0.7289
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0068 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0247 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0334 0.0932
Trypanosoma cruzi metacaspase, putative 0.0017 0.0068 0.1213
Echinococcus granulosus Ankyrin 0.0032 0.0287 0.0267
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0266 0.4553
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0082 0.1149
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1578 1
Schistosoma mansoni hypothetical protein 0.0031 0.0274 0.0271
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0338 0.3256
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0029 0.052
Echinococcus multilocularis peroxidasin 0.0026 0.0195 0.0175
Schistosoma mansoni lamin 0.0026 0.0205 0.0203
Onchocerca volvulus 0.004 0.0416 0.0554
Echinococcus granulosus methionine synthase reductase 0.0016 0.005 0.003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0039 0.0019
Echinococcus granulosus caspase 2 0.0057 0.0676 0.0657
Brugia malayi MAP kinase sur-1 0.005 0.0559 0.0852
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0092 0.0115
Schistosoma mansoni hypothetical protein 0.0165 0.2309 0.2308
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0301 0.4375 0.4364
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0068 0.0048
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0742 0.1141
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0026 0.0201 0.0181
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0017 0.0068 0.0118
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0074 0.0939 0.5898
Brugia malayi Thioredoxin reductase 0.0046 0.0505 0.0766
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0413 0.7289
Plasmodium falciparum thioredoxin reductase 0.0016 0.0048 0.0039
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0413 0.1172
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0068 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0334 0.0932

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 2 ug ml-1 In vitro potentiation of fluconazole antifungal activity in Candida glabrata YEM19 assessed as 8 fold reduction in fluconazole MIC ChEMBL. 17350259
Activity (functional) = 32 ug ml-1 In vitro potentiation of fluconazole antifungal activity in Candida albicans YEM15 assessed as 8 fold reduction in fluconazole MIC ChEMBL. 17350259
Activity (functional) = 32 ug ml-1 In vitro potentiation of fluconazole antifungal activity in Candida albicans YEM15 assessed as 8 fold reduction in fluconazole MIC ChEMBL. 17350259

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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