Detailed information for compound 439869

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 952.857 | Formula: C40H56O26
  • H donors: 0 H acceptors: 10 LogP: -0.79 Rotable bonds: 29
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCO[C@@H]1O[C@H](CO[C@H]2O[C@H](CO[C@H]3O[C@H](COC(=O)C)[C@@H]([C@@H]([C@H]3OC(=O)C)OC(=O)C)OC(=O)C)[C@@H]([C@@H]([C@H]2OC(=O)C)OC(=O)C)OC(=O)C)[C@H]([C@@H]([C@H]1OC(=O)C)OC(=O)C)OC(=O)C
  • InChi: 1S/C40H56O26/c1-12-51-38-35(61-23(9)48)32(58-20(6)45)30(56-18(4)43)27(64-38)14-53-40-37(63-25(11)50)34(60-22(8)47)31(57-19(5)44)28(66-40)15-54-39-36(62-24(10)49)33(59-21(7)46)29(55-17(3)42)26(65-39)13-52-16(2)41/h26-40H,12-15H2,1-11H3/t26-,27-,28-,29+,30-,31+,32+,33+,34+,35-,36-,37-,38-,39+,40+/m1/s1
  • InChiKey: SSUDUTGGWALTEO-CVQXLSMLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0099 0.0098
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0042 0.0213
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0127 0.015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0031 0.003
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0045 0.0175
Brugia malayi Trypsin family protein 0.0039 0.0107 0.0424
Schistosoma mansoni DNA polymerase eta 0.0019 0.0024 0.0015
Echinococcus granulosus dnaJ subfamily B 0.0464 0.1838 0.2182
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0031 0.0119
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0204 0.0203
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0021 0.0031 0.003
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0036 0.0042
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0044 0.0126 0.3321
Echinococcus granulosus neuropeptide receptor 0.0119 0.0429 0.0509
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0107 0.0113
Echinococcus granulosus metabotropic glutamate receptor 5 0.0691 0.2764 0.3282
Loa Loa (eye worm) steroid hormone receptor 0.0044 0.0126 0.0453
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0115 0.0114
Schistosoma mansoni rab6-interacting 0.0022 0.0036 0.0029
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0035 0.004
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0014 0.0064
Schistosoma mansoni lipoxygenase 0.0132 0.0485 0.0563
Brugia malayi PAN domain containing protein 0.0035 0.0091 0.036
Echinococcus multilocularis tyrosine kinase 0.0053 0.0161 0.016
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0049 0.0148 0.0531
Onchocerca volvulus 0.0039 0.0107 0.2634
Entamoeba histolytica hypothetical protein 0.0145 0.0538 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0107 0.0113
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0099 0.0116
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0024 0.0399
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0925
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0022 0.0309
Brugia malayi Guanylyl cyclase protein 23 0.0053 0.0161 0.0646
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0107 0.0113
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0044 0.0126 0.0125
Loa Loa (eye worm) hypothetical protein 0.0044 0.0126 0.0453
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0204 0.0229
Schistosoma mansoni loxhd1 0.0022 0.0036 0.0029
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0107 0.0113
Echinococcus granulosus intermediate filament protein 0.0028 0.006 0.007
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0024 0.0023
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0691 0.2764 0.2763
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0036 0.0887
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0109
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0022 0.0309
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0198 0.7947
Plasmodium falciparum glutathione reductase 0.0054 0.0165 0.6084
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0126 0.0125
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0053 0.0161 0.019
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0022 0.0128
Onchocerca volvulus 0.0061 0.0195 0.5735
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0053 0.0161 0.016
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0115 0.4267
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0035 0.0027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0031 0.0036
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0014 0.0009
Echinococcus multilocularis transmembrane protease serine 3 0.0039 0.0107 0.0106
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0132 0.0485 0.0575
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0247 0.939
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0127 0.0137
Brugia malayi nuclear receptor NHR-88 0.0021 0.0031 0.0119
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0014 0.0009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0044 0.0126 0.0149
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0247 0.9423
Onchocerca volvulus 0.0022 0.0036 0.0179
Loa Loa (eye worm) hypothetical protein 0.0691 0.2764 1
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0053 0.0161 0.016
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0017 0.0109
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0247 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0044 0.0126 0.0504
Echinococcus granulosus cpg binding protein 0.0034 0.0087 0.0102
Echinococcus granulosus dna polymerase kappa 0.0019 0.0024 0.0027
Brugia malayi photoreceptor-specific nuclear receptor 0.0294 0.1144 0.4628
Onchocerca volvulus 0.0035 0.0091 0.2084
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0024 0.0316
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0014 0.0048
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0045 0.0229
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0053 0.0161 0.016
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0115 1
Brugia malayi Cytochrome P450 family protein 0.0049 0.0147 0.0586
Schistosoma mansoni retinoic acid receptor RXR 0.0044 0.0126 0.0136
Mycobacterium tuberculosis Conserved protein 0.0074 0.0247 0.1311
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0022 0.084
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0026 0.029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0325
Brugia malayi PAN domain containing protein 0.0035 0.0091 0.036
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0204 0.0818
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0051 0.0811
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0247 0.1311
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0039 0.0107 0.0125
Brugia malayi Kringle domain containing protein 0.0061 0.0195 0.0784
Echinococcus multilocularis receptor type guanylyl cyclase 0.0053 0.0161 0.016
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0035 0.0091 0.0191
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0126 0.0136
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0101 0.0531
Loa Loa (eye worm) hypothetical protein 0.0053 0.0161 0.058
Onchocerca volvulus 0.0039 0.0107 0.2634
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0044 0.0126 0.0136
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0247 0.1311
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0022 0.0021
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0049 0.0148 0.0147
Echinococcus granulosus tissue type plasminogen activator 0.0061 0.0195 0.0231
Loa Loa (eye worm) hypothetical protein 0.0044 0.0126 0.0453
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0095 0.339
Schistosoma mansoni hypothetical protein 0.0505 0.2006 0.2372
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0205
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0198 0.0447
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0053 0.0161 0.019
Schistosoma mansoni apoferritin-2 0.0017 0.0017 0.0006
Brugia malayi isocitrate dehydrogenase 0.0017 0.0014 0.0051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0126 0.0504
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0325
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0012 0.0011
Echinococcus multilocularis dnaJ subfamily B 0.0464 0.1838 0.1837
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0091 0.0191
Loa Loa (eye worm) beta-lactamase 0.0074 0.0247 0.0889
Schistosoma mansoni zinc finger protein 0.0021 0.0031 0.0023
Schistosoma mansoni ferritin light chain 0.0017 0.0017 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0022 0.0309
Echinococcus granulosus RUN 0.0022 0.0036 0.0042
Mycobacterium ulcerans thioesterase TesA 0.002 0.0029 0.0724
Schistosoma mansoni nuclear receptor 0.0021 0.0031 0.0023
Echinococcus multilocularis geminin 0.0505 0.2006 0.2005
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0074 0.0247 0.0889
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.0134 0.0534
Leishmania major hypothetical protein, conserved 0.0074 0.0247 0.3887
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0024 0.0165
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0044 0.0126 0.0149
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0204 0.0734
Echinococcus multilocularis glutamate receptor 2 0.0053 0.0161 0.016
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0325
Brugia malayi Trypsin family protein 0.0039 0.0107 0.0424
Echinococcus granulosus nuclear receptor nhr 48 0.0021 0.0031 0.0036
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0024 0.0925
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0109
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0101 0.352
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0061 0.0195 0.7321
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0051 0.0811
Onchocerca volvulus 0.0053 0.0161 0.4546
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0031 0.0023
Schistosoma mansoni RAR-like nuclear receptor 0.0044 0.0126 0.0136
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0036 0.0035
Echinococcus multilocularis microtubule associated protein 2 0.2079 0.8418 0.8418
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0126 0.0136
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0091 0.0191
Schistosoma mansoni microtubule-associated protein tau 0.2079 0.8418 1
Brugia malayi Doublecortin family protein 0.0022 0.0036 0.0139
Loa Loa (eye worm) hypothetical protein 0.0053 0.0161 0.058
Schistosoma mansoni polycystin 1-related 0.0022 0.0036 0.0029
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0012 0.0038
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0091 0.0191
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0099 0.9671
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0247 0.028
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.1812 0.2151
Echinococcus multilocularis muscleblind protein 1 0.0619 0.2471 0.247
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0088 0.0087
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0024 0.0399
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0247 0.1311
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0247 0.939
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0109
Echinococcus granulosus atrial natriuretic peptide receptor 0.0053 0.0161 0.019
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0101 0.3678
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0022 0.0105
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0382
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0127 0.0137
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0041 0.0035
Brugia malayi nuclear receptor NHR-88 0.0044 0.0126 0.0504
Entamoeba histolytica hypothetical protein 0.0053 0.0161 0.2669
Echinococcus granulosus nmda type glutamate receptor 0.0053 0.0161 0.019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0109
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0198 0.0222
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0262 1
Loa Loa (eye worm) DR-78 0.0021 0.0031 0.0109
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0247 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0027 0.0132
Echinococcus granulosus sodium channel protein 0.0163 0.0612 0.0726
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.0445 0.2375
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0024 0.0399
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0247 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0132 0.0485 0.0484
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0022 0.0309
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0014 0.0013
Schistosoma mansoni metabotropic glutamate receptor 0.0274 0.1062 0.1249
Toxoplasma gondii thioredoxin reductase 0.0054 0.0165 0.0367
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0126 0.0504
Toxoplasma gondii subtilisin SUB12 0.0035 0.0091 0.0191
Brugia malayi MH2 domain containing protein 0.0126 0.0461 0.186
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0044 0.0126 0.0149
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0115 0.4267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0044 0.0126 0.0453
Loa Loa (eye worm) hypothetical protein 0.0044 0.0127 0.0455
Schistosoma mansoni tyrosine kinase 0.0053 0.0161 0.0178
Mycobacterium ulcerans polyketide synthase 0.0026 0.0051 0.1687
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0115 0.0249
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0051 0.0097
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0024 0.0091
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0045 0.1426
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0017 0.0226
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0017 0.0017 0.008
Onchocerca volvulus 0.0074 0.0247 0.7522
Brugia malayi Trypsin-like protease protein 5 0.0039 0.0107 0.0424
Onchocerca volvulus 0.0035 0.0091 0.2084
Brugia malayi steroid hormone receptor 0.0044 0.0126 0.0504
Brugia malayi nuclear hormone receptor 0.0044 0.0126 0.0504
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0126 0.0136
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0084
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.0029 0.0348
Onchocerca volvulus 0.0039 0.0107 0.2634
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0153 0.0551
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0099 0.3564
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0925
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0018 0.002 0.0019
Schistosoma mansoni protein kinase 0.0053 0.0161 0.0178
Brugia malayi Trypsin family protein 0.0039 0.0107 0.0424
Echinococcus multilocularis expressed protein 0.0017 0.0017 0.0016
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0022 0.0309
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0018 0.002 0.0019
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0045 0.0229
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0022 0.084
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.0031 0.0119
Loa Loa (eye worm) hypothetical protein 0.0074 0.0247 0.0889
Onchocerca volvulus 0.0035 0.0091 0.2084
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0107 0.0113
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0044 0.0126 0.0136
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0018 0.002 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0127 0.0126
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0145 0.0538 0.0537
Loa Loa (eye worm) nuclear hormone receptor 0.0021 0.0031 0.0109
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0049 0.0148 0.0591
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0115 0.4397
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0101 0.8619
Brugia malayi hypothetical protein 0.0022 0.0036 0.0139
Schistosoma mansoni lamin 0.0028 0.006 0.0057
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0045 0.1426
Onchocerca volvulus 0.0042 0.0118 0.3045
Schistosoma mansoni steroid hormone receptor ad4bp 0.0044 0.0126 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0109
Loa Loa (eye worm) RNA binding protein 0.0063 0.0204 0.0734
Echinococcus granulosus ferritin 0.0017 0.0017 0.0019
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0101 0.1502
Brugia malayi Cyclic-nucleotide gated cation channel 0.0018 0.002 0.0074
Toxoplasma gondii PAN domain-containing protein 0.033 0.1293 0.3048
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0099 0.1451
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0036 0.0042
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0122
Toxoplasma gondii PAN/Apple domain-containing protein 0.0035 0.0091 0.0191
Brugia malayi PAN domain containing protein 0.0035 0.0091 0.036
Echinococcus granulosus dna polymerase eta 0.0019 0.0024 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0022 0.0309
Echinococcus multilocularis musashi 0.0028 0.006 0.0059
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0107 0.0113
Loa Loa (eye worm) hypothetical protein 0.0074 0.0247 0.0889
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0925
Echinococcus multilocularis Mastin 0.0039 0.0107 0.0106
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0461 0.1665
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0039 0.0136
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0026 0.0603
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0382
Echinococcus multilocularis ecdysone induced protein 78C 0.0044 0.0126 0.0125
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0041 0.0048
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0051 0.0262
Onchocerca volvulus 0.0039 0.0107 0.2634
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0039 0.0107 0.0424
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0247 0.939
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0041 0.0035
Brugia malayi nuclear receptor NHR-67 0.0021 0.0031 0.0119
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0022 0.5
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0163 0.0612 1
Mycobacterium ulcerans beta-lactamase 0.0074 0.0247 1
Echinococcus granulosus FTZ F1 alpha 0.0044 0.0126 0.0149
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0053 0.0161 0.0646
Echinococcus granulosus muscleblind protein 0.0619 0.2471 0.2934
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0262 0.0598
Loa Loa (eye worm) hypothetical protein 0.0037 0.0099 0.0354
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.0162 0.0179
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0471 0.1866 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0127 0.0508
Schistosoma mansoni inositol monophosphatase 0.0041 0.0115 0.0123
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0018 0.002 0.0069
Schistosoma mansoni ferritin 0.0017 0.0017 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0126 0.0504
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0012 0.0013
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0091 0.0325
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0099 0.3564
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0022 0.0513
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0036 0.0094 0.0492
Loa Loa (eye worm) hypothetical protein 0.0053 0.0161 0.058
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0247 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0247 0.0992
Leishmania major DNA polymerase kappa, putative 0.0019 0.0024 0.0165
Treponema pallidum NADH oxidase 0.0019 0.0022 0.0595
Echinococcus granulosus lamin 0.0028 0.006 0.007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0198 0.1052
Onchocerca volvulus Protein ultraspiracle homolog 0.0044 0.0126 0.3321
Loa Loa (eye worm) TK/ROR protein kinase 0.0061 0.0195 0.0704
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0204 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0126 0.0504
Trypanosoma brucei trypanothione reductase 0.0054 0.0165 0.6299
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0101 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0061 0.0195 0.7321
Loa Loa (eye worm) intermediate filament protein 0.0028 0.006 0.0213
Echinococcus granulosus transmembrane protease serine 3 0.0039 0.0107 0.0125
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0107 0.0113
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0022 0.0012
Toxoplasma gondii hypothetical protein 0.0035 0.0091 0.0191
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0099 0.0104
Schistosoma mansoni hypothetical protein 0.0035 0.0088 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0044 0.0126 0.0453
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0109
Loa Loa (eye worm) hypothetical protein 0.0074 0.0247 0.0889
Leishmania major DNA polymerase eta, putative 0.0019 0.0024 0.0165
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0325
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0198 0.7947
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0115 0.4392
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0022 0.0025
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0035 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0024 0.0399
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0036 0.0035
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0018 0.002 0.001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0088 0.0314
Echinococcus granulosus hyperpolarization activated cyclic 0.0018 0.002 0.0023
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0165 0.6084
Entamoeba histolytica hypothetical protein 0.0145 0.0538 1
Schistosoma mansoni hypothetical protein 0.0035 0.0088 0.009
Brugia malayi PAN domain containing protein 0.0035 0.0091 0.036
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.006 0.0235
Onchocerca volvulus 0.0044 0.0126 0.3321
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0262 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0044 0.0126 0.0136
Echinococcus multilocularis nuclear receptor nhr 48 0.0021 0.0031 0.003
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0247 1
Echinococcus granulosus tar DNA binding protein 0.0063 0.0204 0.0241
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0018 0.002 0.001
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0017 0.0078
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0012 0.004
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0101 0.352
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0022 0.044
Echinococcus granulosus microtubule associated protein 2 0.2079 0.8418 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0012 0.0013
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0099 0.3775
Schistosoma mansoni ferritin 0.0017 0.0017 0.0006
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0014 0.0002
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0021 0.0031 0.0023
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0014 0.0548
Mycobacterium tuberculosis Conserved protein 0.0074 0.0247 0.1311
Onchocerca volvulus 0.0039 0.0107 0.2634
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0044 0.0126 0.0453
Loa Loa (eye worm) hypothetical protein 0.0023 0.0041 0.0146
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0163 0.0612 0.0726
Echinococcus granulosus metabotropic glutamate receptor 2 0.047 0.1864 0.2213
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0109
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0018 0.002 0.0023
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0021 0.0031 0.0109
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0115 0.0135
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0099 0.0098
Schistosoma mansoni apoferritin-2 0.0017 0.0017 0.0006
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0051 0.1687
Brugia malayi conserved hypotetical protein 0.0021 0.0031 0.0119
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0247 0.1311
Loa Loa (eye worm) hypothetical protein 0.0044 0.0126 0.0453
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0165 0.6084
Leishmania major extracellular receptor, putative 0.0053 0.0161 0.2461
Echinococcus multilocularis RUN 0.0022 0.0036 0.0035
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.006 0.0213
Onchocerca volvulus 0.0035 0.0091 0.2084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0041 0.0146
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0044 0.0126 0.0453
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0125 0.326
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0018 0.002 0.0069
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0022 0.0128
Brugia malayi Inositol-1 0.0041 0.0115 0.0458
Mycobacterium ulcerans thioesterase 0.002 0.0029 0.0724
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0051 0.1687
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0022 0.0309
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0022 0.0309
Echinococcus multilocularis nmda type glutamate receptor 0.0053 0.0161 0.016
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0024 0.0117
Brugia malayi Protein kinase domain containing protein 0.0061 0.0195 0.0784
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0051 0.0262
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0509 0.202 0.8174
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0044 0.0126 0.0149
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0031 0.0036
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0036 0.0035
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0017 0.0226
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0165 0.0593
Loa Loa (eye worm) hypothetical protein 0.0023 0.0041 0.0146
Brugia malayi nuclear receptor RXR 0.0021 0.0031 0.0119
Brugia malayi Thioredoxin reductase 0.0054 0.0165 0.066
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0198 0.0446
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0036 0.0887
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0045 0.0685
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0382
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0262 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0045 0.1426
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0097 0.0509
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0022 0.0219
Brugia malayi hypothetical protein 0.0021 0.0031 0.0119
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0115 0.1766
Echinococcus multilocularis FTZ F1 alpha 0.0044 0.0126 0.0125
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0099 0.0116
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0101 0.0363
Onchocerca volvulus 0.0035 0.0091 0.2084
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0018 0.002 0.001
Toxoplasma gondii hypothetical protein 0.0035 0.0091 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0925
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0091 0.0325
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0088 0.0103
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0044 0.0126 0.0504
Loa Loa (eye worm) hypothetical protein 0.0023 0.0041 0.0146
Echinococcus multilocularis glycoprotein Antigen 5 0.0039 0.0107 0.0106
Brugia malayi hypothetical protein 0.0023 0.0041 0.016
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0107 0.0113
Echinococcus multilocularis thyroid hormone receptor alpha 0.0044 0.0126 0.0125
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0115 0.4067
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0041 0.016
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0053 0.0161 0.016
Brugia malayi hypothetical protein 0.0023 0.0041 0.016
Echinococcus granulosus hyperpolarization activated cyclic 0.0018 0.002 0.0023
Echinococcus granulosus ecdysone induced protein 78C 0.0044 0.0126 0.0149
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0115 0.4067
Loa Loa (eye worm) hypothetical protein 0.0077 0.0262 0.0944
Loa Loa (eye worm) RGC/RGC protein kinase 0.0053 0.0161 0.058
Mycobacterium ulcerans polyketide synthase 0.0024 0.0045 0.1426
Brugia malayi nuclear receptor RXR 0.0023 0.0041 0.016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0109
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0099 0.1414
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0099 0.3415
Brugia malayi beta-lactamase 0.0074 0.0247 0.0992
Mycobacterium ulcerans polyketide synthase Pks13 0.0036 0.0094 0.3508
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0144 0.0533 0.1925
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0039 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0044 0.0126 0.0504
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.002 0.001
Plasmodium falciparum thioredoxin reductase 0.0054 0.0165 0.6084
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0101 0.3678
Brugia malayi Receptor family ligand binding region containing protein 0.0053 0.0161 0.0646
Loa Loa (eye worm) hypothetical protein 0.0053 0.0161 0.058
Loa Loa (eye worm) glutamate receptor 0.0562 0.2235 0.8086
Schistosoma mansoni nuclear receptor nhr-48 0.0021 0.0031 0.0023
Loa Loa (eye worm) hypothetical protein 0.0044 0.0126 0.0453
Mycobacterium ulcerans hypothetical protein 0.0074 0.0247 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0024 0.0535
Onchocerca volvulus 0.0028 0.006 0.1005
Brugia malayi nuclear hormone receptor 0.0021 0.0031 0.0119
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0045 0.1426
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0198 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0925
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0018 0.002 0.0023
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.0445 0.2375
Schistosoma mansoni lipoxygenase 0.0092 0.0323 0.037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0127 0.0137
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0247 1
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0247 0.4806
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0044 0.0126 0.0125
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0053 0.0161 0.4546
Echinococcus granulosus glycoprotein Antigen 5 0.0039 0.0107 0.0125
Echinococcus multilocularis lamin 0.0028 0.006 0.0059
Brugia malayi PAN domain containing protein 0.0035 0.0091 0.036
Onchocerca volvulus 0.0028 0.006 0.1005
Loa Loa (eye worm) hypothetical protein 0.0619 0.2471 0.8938
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0144 0.0533 0.1925
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0045 0.0229
Toxoplasma gondii microneme protein MIC17B 0.0035 0.0091 0.0191
Schistosoma mansoni hypothetical protein 0.0505 0.2006 0.2372
Schistosoma mansoni hypothetical protein 0.0022 0.0036 0.0029
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0153 0.0613
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0022 0.044
Trypanosoma cruzi extracellular receptor, putative 0.0053 0.0161 0.5944
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0079 0.0282
Trypanosoma brucei unspecified product 0.0019 0.0024 0.0925
Brugia malayi hypothetical protein 0.0022 0.0036 0.0139
Echinococcus multilocularis tissue type plasminogen activator 0.0061 0.0195 0.0194
Toxoplasma gondii microneme protein MIC17A 0.0035 0.0091 0.0191
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.0031 0.0119
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0204 0.0734
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0024 0.0023
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.0501 0.2674
Brugia malayi Trypsin family protein 0.0039 0.0107 0.0424
Toxoplasma gondii microneme protein, putative 0.0035 0.0091 0.0191
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0101 1
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0639 0.2549 0.3018
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0044 0.0126 0.0136
Toxoplasma gondii PAN domain-containing protein 0.033 0.1293 0.3048
Mycobacterium tuberculosis Conserved protein 0.0074 0.0247 0.1311
Brugia malayi PAN domain containing protein 0.0035 0.0091 0.036
Loa Loa (eye worm) hypothetical protein 0.0053 0.0161 0.058
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0101 0.1457
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0145 0.0538 0.0638
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.0501 0.2674
Loa Loa (eye worm) hypothetical protein 0.0044 0.0126 0.0453
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0262 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0198 0.308
Schistosoma mansoni hypothetical protein 0.0091 0.0318 0.0364
Brugia malayi RNA binding protein 0.0063 0.0204 0.0818
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0018 0.002 0.0023
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0091 0.0191
Schistosoma mansoni glutamate receptor NMDA 0.0053 0.0161 0.0178
Mycobacterium ulcerans lipase LipD 0.0074 0.0247 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.0501 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0107 0.0113
Brugia malayi Metabotropic glutamate receptor precursor. 0.0562 0.2235 0.9046
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0022 0.0081
Toxoplasma gondii microneme protein MIC4 0.0035 0.0091 0.0191
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0109
Echinococcus multilocularis glutamate receptor 2 0.0053 0.0161 0.016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0044 0.0126 0.0453
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0024 0.0316
Brugia malayi tailless protein 0.0021 0.0031 0.0119
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0127 0.0456
Schistosoma mansoni tyrosine kinase 0.0053 0.0161 0.0178
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.0445 0.2375
Echinococcus multilocularis GPCR, family 2 0.0016 0.0012 0.0011
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.0445 0.2375
Giardia lamblia DINP protein human, muc B family 0.0019 0.0024 0.0281
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0035 0.0034
Toxoplasma gondii microneme protein MIC17C 0.0035 0.0091 0.0191
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0022 0.0513
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0247 1
Brugia malayi hypothetical protein 0.0039 0.0107 0.0424
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0022 0.0309
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0024 0.0925
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0099 0.0116
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0014 0.0016
Plasmodium falciparum thioredoxin reductase 0.0019 0.0022 0.0309
Schistosoma mansoni hypothetical protein 0.0145 0.0538 0.0626
Schistosoma mansoni cpg binding protein 0.0034 0.0087 0.0089
Loa Loa (eye worm) hypothetical protein 0.0091 0.0318 0.1146
Echinococcus granulosus receptor type guanylyl cyclase 0.0053 0.0161 0.019
Echinococcus granulosus thyroid hormone receptor alpha 0.0021 0.0031 0.0036
Brugia malayi hypothetical protein 0.0077 0.0262 0.1053
Loa Loa (eye worm) hypothetical protein 0.0619 0.2471 0.8938
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0107 0.0113
Schistosoma mansoni lamin 0.0028 0.006 0.0057
Echinococcus granulosus lamin dm0 0.0028 0.006 0.007
Brugia malayi Receptor family ligand binding region containing protein 0.0144 0.0533 0.2151
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0101 0.352
Echinococcus multilocularis GPCR, family 3, C terminal 0.0091 0.0318 0.0317
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0053 0.0161 0.019
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0126 0.0504
Onchocerca volvulus 0.0035 0.0091 0.2084
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0101 0.352
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0035 0.0027
Plasmodium vivax glutathione reductase, putative 0.0054 0.0165 0.6084
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0228 0.0257
Brugia malayi PAN domain containing protein 0.0035 0.0091 0.036
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0099 0.0104
Schistosoma mansoni ferritin light chain 0.0017 0.0017 0.0006
Echinococcus multilocularis ferritin 0.0017 0.0017 0.0016
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0198 0.0222
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0107 0.0113
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0018 0.002 0.0136
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0091 0.0325
Brugia malayi ecdysteroid receptor 0.0044 0.0126 0.0504
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0107 0.0113
Onchocerca volvulus 0.0023 0.0039 0.0261
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0044 0.0126 0.0125
Loa Loa (eye worm) hypothetical protein 0.0074 0.0247 0.0889
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0247 0.1311
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0022 0.0309
Leishmania major hypothetical protein, conserved 0.0061 0.0195 0.3031
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0031 0.0023
Schistosoma mansoni ferritin 0.0017 0.0017 0.0006
Onchocerca volvulus 0.0035 0.0091 0.2084
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0014 0.0013
Loa Loa (eye worm) trypsin family protein 0.0039 0.0107 0.0382
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0035 0.0034
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.0031 0.0119
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0041 0.0146
Echinococcus multilocularis G protein coupled receptor 139 0.0119 0.0429 0.0428
Onchocerca volvulus 0.0022 0.0036 0.0179
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0091 0.0318 0.1279
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0017 0.0078
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0091 0.0325
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0461 0.1665
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0014 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0041 0.016
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0024 0.0925
Entamoeba histolytica hypothetical protein 0.0145 0.0538 1
Brugia malayi PAN domain containing protein 0.0035 0.0091 0.036
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0044 0.0126 0.0136
Schistosoma mansoni cpg binding protein 0.0033 0.0079 0.008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0325
Toxoplasma gondii kringle domain-containing protein 0.0061 0.0195 0.044
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0022 0.084
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0247 0.1311
Loa Loa (eye worm) glutamate receptor 0.0221 0.0847 0.306
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0107 0.0113
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0053 0.0161 0.058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0127
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0036 0.0094 0.0492
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0024 0.0399
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0198 0.0234
Onchocerca volvulus 0.0035 0.0091 0.2084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0127 0.015
Schistosoma mansoni 60S ribosomal protein L21 0.0017 0.0014 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0115 0.4267
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0024 0.0117
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0022 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0925
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.0445 0.2375
Loa Loa (eye worm) hypothetical protein 0.0044 0.0126 0.0453
Loa Loa (eye worm) RGC/RGC protein kinase 0.0053 0.0161 0.058
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0024 0.0015
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0161 0.058
Schistosoma mansoni transcription factor LCR-F1 0.0145 0.0538 0.0626
Schistosoma mansoni rab6-interacting 0.0022 0.0036 0.0029
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0223 0.0853 0.1001
Brugia malayi intermediate filament protein 0.0028 0.006 0.0235
Loa Loa (eye worm) hypothetical protein 0.0051 0.0153 0.0551
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0031 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0213
Loa Loa (eye worm) hypothetical protein 0.0044 0.0126 0.0453
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0195 0.7321
Echinococcus granulosus neuropeptide s receptor 0.0458 0.1812 0.2151
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0095 0.339
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0382
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0053 0.0161 0.019
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0022 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0044 0.0126 0.0453
Loa Loa (eye worm) hypothetical protein 0.0074 0.0247 0.0889
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0039 0.0194
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0014 0.0548
Schistosoma mansoni ap endonuclease 0.0038 0.0101 0.0107
Brugia malayi hypothetical protein 0.0053 0.0161 0.0646
Echinococcus multilocularis neuropeptide receptor 0.0119 0.0429 0.0428
Onchocerca volvulus 0.0053 0.0161 0.4546
Brugia malayi beta-lactamase family protein 0.0074 0.0247 0.0992
Loa Loa (eye worm) hypothetical protein 0.0041 0.0112 0.0403
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0031 0.0119
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0165 0.0164
Onchocerca volvulus 0.0033 0.0079 0.167
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0038
Brugia malayi PAN domain containing protein 0.0035 0.0091 0.036
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0247 0.0292
Schistosoma mansoni nuclear receptor 0.0021 0.0031 0.0023
Echinococcus multilocularis sodium channel protein 0.0163 0.0612 0.0611
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0044 0.0126 0.0504
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0247 1
Echinococcus granulosus expressed protein 0.0017 0.0017 0.0019
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0107 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0044 0.0126 0.0504
Loa Loa (eye worm) glutathione reductase 0.0054 0.0165 0.0593
Mycobacterium tuberculosis Probable reductase 0.0122 0.0445 0.2375
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0021 0.0031 0.003
Echinococcus multilocularis enteropeptidase 0.0039 0.0107 0.0106
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0101 0.3875
Brugia malayi glutathione reductase 0.0054 0.0165 0.066
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0325
Schistosoma mansoni coup transcription factor 0.0044 0.0126 0.0136
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0051 0.0262
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0126 0.0125
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0012 0.0011
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0031 0.003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0044 0.0126 0.0149
Echinococcus multilocularis cpg binding protein 0.0034 0.0087 0.0086
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0022 0.0028
Echinococcus granulosus Mastin 0.0039 0.0107 0.0125
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0024 0.0091
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1224 0.4935 0.5856
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0021 0.0031 0.0023
Onchocerca volvulus 0.0074 0.0247 0.7522
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0382
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0022 0.0028
Schistosoma mansoni cpg binding protein 0.0034 0.0087 0.0089
Brugia malayi hypothetical protein 0.005 0.015 0.06
Brugia malayi CXXC zinc finger family protein 0.0033 0.0079 0.0313
Brugia malayi Steroid receptor seven-up type 2 0.0044 0.0126 0.0504
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0107 0.0113
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0204 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0925
Loa Loa (eye worm) nuclear receptor NHR-67 0.0021 0.0031 0.0109
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0107 0.0113
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0035 0.0133
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0014 0.0013
Echinococcus granulosus glutamate receptor 2 0.0053 0.0161 0.019
Schistosoma mansoni hypothetical protein 0.0039 0.0107 0.0113
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0051 0.0811
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0024 0.0535
Echinococcus granulosus GPCR family 3 C terminal 0.0091 0.0318 0.0376
Brugia malayi hypothetical protein 0.0145 0.0538 0.2173
Loa Loa (eye worm) hypothetical protein 0.0023 0.0041 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0022 0.0309
Echinococcus multilocularis metabotropic glutamate receptor 2 0.047 0.1864 0.1863
Onchocerca volvulus 0.0039 0.0107 0.2634
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0039 0.0107 0.0113
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0099 0.3564
Loa Loa (eye worm) inositol-1 0.0041 0.0115 0.0412
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0126 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0204 0.0229
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.0029 0.0141
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0044 0.0126 0.0125
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0107 0.0113
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0107 0.0113
Echinococcus granulosus enteropeptidase 0.0039 0.0107 0.0125
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0024 0.0084
Schistosoma mansoni hypothetical protein 0.0061 0.0195 0.0219
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0042 0.0213
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0039 0.0107 0.0106
Onchocerca volvulus 0.0035 0.0091 0.2084
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0101 0.0119
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0101 0.01
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0247 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0925
Schistosoma mansoni neuropeptide receptor 0.0119 0.0429 0.0497
Schistosoma mansoni ferritin 0.0017 0.0017 0.0006
Echinococcus multilocularis dna polymerase eta 0.0019 0.0024 0.0023
Schistosoma mansoni inositol monophosphatase 0.0041 0.0115 0.0123
Brugia malayi Muscleblind-like protein 0.0619 0.2471 1
Toxoplasma gondii ABC1 family protein 0.0074 0.0247 0.0562
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0018 0.002 0.0019
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0024 0.0925
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0126 0.0136
Leishmania major trypanothione reductase 0.0054 0.0165 0.2519
Onchocerca volvulus 0.0035 0.0091 0.2084
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0109
Plasmodium falciparum glutathione reductase 0.0019 0.0022 0.0309
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0147 0.0527
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0069
Onchocerca volvulus Poor gastrulation protein homolog 0.0091 0.0318 1
Schistosoma mansoni ap endonuclease 0.0038 0.0101 0.0107
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0018 0.002 0.0136
Brugia malayi ecdysone receptor 0.0021 0.0031 0.0119
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0091 0.0325
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0024 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0044 0.0126 0.0504
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0044 0.0155
Loa Loa (eye worm) hypothetical protein 0.0294 0.1144 0.4138
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0044 0.0126 0.0504
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0198 0.7947
Schistosoma mansoni intermediate filament proteins 0.0028 0.006 0.0057
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0101 0.0403
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0204 0.0229
Echinococcus multilocularis hyperpolarization activated cyclic 0.0018 0.002 0.0019
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.0501 0.2674
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0099 0.3415
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0165 0.0195
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0127 0.0126
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0109
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0088 0.0348
Onchocerca volvulus Bile acid receptor homolog 0.0044 0.0126 0.3321
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0007 0.0021
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0031 0.003
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0091 0.0318 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0045 0.0685
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.1048 0.4217 1
Echinococcus multilocularis lamin dm0 0.0028 0.006 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0044 0.0126 0.0453
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0925
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0007 0.0022
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0022 0.0128
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0049 0.0148 0.0174
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0247 0.0889
Toxoplasma gondii exonuclease III APE 0.0038 0.0101 0.0216
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0126 0.0149
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0097 0.1752
Echinococcus granulosus geminin 0.0505 0.2006 0.2382
Onchocerca volvulus 0.0074 0.0247 0.7522
Loa Loa (eye worm) hypothetical protein 0.0061 0.0195 0.0704
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0126 0.0504
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0021 0.0031 0.0036
Brugia malayi metabotropic glutamate receptor type 2 0.0274 0.1062 0.4294
Echinococcus granulosus glutamate receptor 2 0.0053 0.0161 0.019
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0247 0.1311
Echinococcus multilocularis muscleblind protein 0.0619 0.2471 0.247
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0018 0.002 0.0023
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0026 0.0603
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0099 0.0393
Loa Loa (eye worm) hypothetical protein 0.0053 0.0161 0.058
Schistosoma mansoni metabotropic glutamate receptor 0.047 0.1864 0.2203
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.0445 0.8862
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0024 0.0015
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0014 0.0051
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.1812 0.1811
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0022 0.084
Leishmania major hypothetical protein, conserved 0.0077 0.0262 0.414
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0101 0.3821
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.0031 0.0119
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0014 0.0003
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0107 0.0106
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0144 0.0533 0.1925
Echinococcus multilocularis hyperpolarization activated cyclic 0.0018 0.002 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0126 0.0504
Entamoeba histolytica hypothetical protein 0.0145 0.0538 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0165 0.0872
Echinococcus granulosus tyrosine kinase 0.0053 0.0161 0.019
Trichomonas vaginalis esterase, putative 0.0074 0.0247 1
Brugia malayi hypothetical protein 0.0021 0.0031 0.0119
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0012 0.004
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0022 0.044
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0022 0.0309
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0036 0.0042
Mycobacterium leprae Polyketide synthase Pks13 0.0036 0.0094 0.1686
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0325
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0036 0.0127
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0039 0.0107 0.0125
Brugia malayi PAN domain containing protein 0.0035 0.0091 0.036
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0115 0.1684
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0382
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0153 0.0613
Echinococcus granulosus GPCR family 2 0.0016 0.0012 0.0013
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0014 0.0013
Brugia malayi TAR-binding protein 0.0063 0.0204 0.0818
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0018 0.002 0.001
Brugia malayi beta-lactamase family protein 0.0074 0.0247 0.0992
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.0162 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0925
Schistosoma mansoni hypothetical protein 0.0039 0.0107 0.0113
Mycobacterium leprae Probable lipase LipE 0.0074 0.0247 0.4806
Schistosoma mansoni hypothetical protein 0.0464 0.1838 0.2172
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0022 0.0128
Loa Loa (eye worm) RGC/RGC protein kinase 0.0053 0.0161 0.058
Onchocerca volvulus 0.0035 0.0091 0.2084
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0053 0.0161 0.016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0109
Mycobacterium ulcerans hypothetical protein 0.0039 0.0107 0.4042
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0382
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.1812 0.1811

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) 0 Antibacterial activity against Mycobacterium avium 724S after 2 weeks by broth dilution method ChEMBL. 17331717
MIC (functional) 0 Antibacterial activity against methicillin-resistant Staphylococcus aureus 873 after 2 weeks by broth dilution method ChEMBL. 17331717
MIC (functional) 0 Antibacterial activity against methicillin-resistant Staphylococcus aureus 906 after 2 weeks by broth dilution method ChEMBL. 17331717
MIC (functional) 0 Antibacterial activity against methicillin-resistant Staphylococcus aureus 908 after 2 weeks by broth dilution method ChEMBL. 17331717
MIC (functional) 0 Antibacterial activity against methicillin-resistant Staphylococcus aureus 910 after 2 weeks by broth dilution method ChEMBL. 17331717
MIC (functional) > 800 ug ml-1 Antibacterial activity against Mycobacterium tuberculosis H37Rv after 2 weeks by broth dilution method ChEMBL. 17331717
MIC (functional) > 800 ug ml-1 Antibacterial activity against Staphylococcus aureus after 2 weeks by broth dilution method ChEMBL. 17331717
MIC (functional) > 800 ug ml-1 Antibacterial activity against Mycobacterium tuberculosis H37Rv after 2 weeks by broth dilution method ChEMBL. 17331717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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