Detailed information for compound 454643

Basic information

Technical information
  • TDR Targets ID: 454643
  • Name: [(2S,4S)-4-[4-(5-nitropyridin-2-yl)piperazin- 1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)m ethanone
  • MW: 392.476 | Formula: C17H24N6O3S
  • H donors: 1 H acceptors: 4 LogP: 0.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CSCC1)[C@H]1NC[C@H](C1)N1CCN(CC1)c1ccc(cn1)[N+](=O)[O-]
  • InChi: 1S/C17H24N6O3S/c24-17(22-7-8-27-12-22)15-9-14(11-18-15)20-3-5-21(6-4-20)16-2-1-13(10-19-16)23(25)26/h1-2,10,14-15,18H,3-9,11-12H2/t14-,15-/m0/s1
  • InChiKey: MAZMJZPWHREVQB-GJZGRUSLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2S,4S)-4-[4-(5-nitro-2-pyridyl)piperazin-1-yl]pyrrolidin-2-yl]-thiazolidin-3-yl-methanone
  • [(2S,4S)-4-[4-(5-nitro-2-pyridyl)-1-piperazinyl]-2-pyrrolidinyl]-(3-thiazolidinyl)methanone
  • [(2S,4S)-4-[4-(5-nitro-2-pyridyl)piperazino]pyrrolidin-2-yl]-thiazolidin-3-yl-methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References
Rattus norvegicus Dipeptidyl peptidase IV Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor Dipeptidyl peptidase IV   767 aa 814 aa 25.6 %
Candida albicans dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor Dipeptidyl peptidase IV   767 aa 814 aa 25.6 %
Onchocerca volvulus Dipeptidyl peptidase IV   767 aa 637 aa 27.0 %
Onchocerca volvulus Dipeptidyl peptidase IV   767 aa 789 aa 30.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ecdysteroid receptor 0.0371 0.4227 0.8835
Schistosoma mansoni nuclear hormone receptor 0.0371 0.4227 0.8835
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0181 0.0352
Schistosoma mansoni intermediate filament proteins 0.0055 0.0513 0.1072
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.026 0.0544
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0049 0.0049
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0392 0.447 0.9344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0317 0.1559
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0341 0.0663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0371 0.4227 0.8835
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0026 0.0172 0.0256
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0033 0.026 0.0456
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.026 0.1279
Schistosoma mansoni hypothetical protein 0.0015 0.0049 0.0103
Echinococcus multilocularis prolyl endopeptidase 0.0033 0.026 0.026
Echinococcus granulosus Ankyrin 0.0015 0.0052 0.0101
Schistosoma mansoni nuclear receptor 0.0175 0.1926 0.4025
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0432 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0371 0.4227 0.8835
Echinococcus granulosus neuropeptide receptor A26 0.0448 0.5137 1
Toxoplasma gondii prolyl endopeptidase 0.0033 0.026 0.1709
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0371 0.4227 0.8229
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0033 0.026 0.1709
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.026 0.6023
Brugia malayi hypothetical protein 0.0024 0.0156 0.0327
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0033 0.026 0.0544
Loa Loa (eye worm) hypothetical protein 0.0026 0.0181 0.0378
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0561 0.1172
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0033 0.026 0.0456
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0371 0.4227 0.4227
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0432 0.0903
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0371 0.4227 0.8229
Toxoplasma gondii hypothetical protein 0.0033 0.026 0.1709
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.004 0.0194
Brugia malayi conserved hypotetical protein 0.0175 0.1926 0.4025
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0392 0.447 0.9344
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0011 0.0005 0.0005
Brugia malayi CHD4 protein 0.0013 0.0019 0.0039
Loa Loa (eye worm) hypothetical protein 0.0175 0.1926 0.4025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0371 0.4227 0.4227
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0371 0.4227 0.8835
Echinococcus granulosus prolyl endopeptidase 0.0033 0.026 0.0507
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0196 0.2172 0.454
Brugia malayi M-phase phosphoprotein, mpp8 0.0098 0.1018 0.2127
Brugia malayi cytochrome P450 0.0026 0.0172 0.036
Loa Loa (eye worm) hypothetical protein 0.0098 0.1019 0.213
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0432 0.0846
Loa Loa (eye worm) hypothetical protein 0.0033 0.0257 0.0537
Leishmania major cytochrome p450-like protein 0.0043 0.0381 0.0729
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0341 0.0341
Schistosoma mansoni hypothetical protein 0.0394 0.4502 0.9411
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0005 0.0027
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0379 0.0792
Brugia malayi hypothetical protein 0.0175 0.1926 0.4025
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0432 0.0841
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0059 0.0124
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0184 0.2035 1
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0087 0.0889 0.0889
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0035 0.0284 0.099
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0371 0.4227 0.8229
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0035 0.0284 0.099
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0015 0.0044 0.0085
Loa Loa (eye worm) hypothetical protein 0.0371 0.4227 0.8835
Echinococcus granulosus Dipeptidyl peptidase 9 0.0141 0.1523 0.2965
Loa Loa (eye worm) hypothetical protein 0.0018 0.008 0.0166
Treponema pallidum hypothetical protein 0.003 0.0223 1
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0087 0.0891 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0317 0.1559
Onchocerca volvulus 0.0055 0.0513 0.1072
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0172 0.0256
Echinococcus granulosus RUN 0.0021 0.0117 0.0228
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0141 0.1523 0.3318
Leishmania major hypothetical protein, conserved 0.0024 0.0156 0.022
Loa Loa (eye worm) cytochrome P450 family protein 0.0085 0.0865 0.1807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0174 0.0855
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0049 0.0103
Echinococcus multilocularis voltage gated potassium channel 0.0015 0.0044 0.0044
Brugia malayi hypothetical protein 0.0016 0.0055 0.0115
Onchocerca volvulus Protein ultraspiracle homolog 0.0371 0.4227 0.8835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0174 0.0853
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0104 0.0102
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0122 0.1305 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.2172 0.454
Schistosoma mansoni thyroid hormone receptor 0.0371 0.4227 0.8835
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0196 0.2172 0.454
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0371 0.4227 0.8835
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0074 0.0362
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0156 0.6004
Leishmania major oligopeptidase b 0.0033 0.026 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0059 0.0291
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0005 0.0011
Schistosoma mansoni nuclear hormone receptor 0.0175 0.1926 0.4025
Echinococcus multilocularis RUN 0.0021 0.0117 0.0117
Schistosoma mansoni lipoxygenase 0.0125 0.1344 0.2809
Schistosoma mansoni cpg binding protein 0.0029 0.0215 0.0449
Schistosoma mansoni thyroid hormone receptor 0.0371 0.4227 0.8835
Schistosoma mansoni cpg binding protein 0.0028 0.0196 0.041
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0196 0.2172 0.4229
Echinococcus granulosus dnaJ subfamily B 0.0394 0.4502 0.8765
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0791 0.1539
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0288 0.1417
Brugia malayi tailless protein 0.0175 0.1926 0.4025
Toxoplasma gondii cytochrome p450 superfamily protein 0.0026 0.0172 0.113
Onchocerca volvulus 0.0021 0.0117 0.0245
Loa Loa (eye worm) hypothetical protein 0.0175 0.1926 0.4025
Brugia malayi hypothetical protein 0.0108 0.1133 0.2369
Echinococcus multilocularis sodium channel protein 0.0071 0.0701 0.0701
Loa Loa (eye worm) prolyl oligopeptidase 0.0418 0.4784 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0175 0.1926 0.1926
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0011 0.0005 0.0011
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0059 0.0059
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0172 0.0256
Echinococcus multilocularis ecdysone induced protein 78C 0.0371 0.4227 0.4227
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0184 0.2035 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.1926 0.4025
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0087 0.0891 0.6351
Loa Loa (eye worm) hypothetical protein 0.0033 0.026 0.0544
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0074 0.0362
Echinococcus granulosus Chromobox protein 3 0.0011 0.00000002929 0.000000057021
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0175 0.1926 0.4025
Schistosoma mansoni hypothetical protein 0.0033 0.0257 0.0537
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0371 0.4227 0.8835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0021 0.0106
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0062 0.0602 0.3793
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0341 0.0712
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0033 0.026 0.1279
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.026 0.0544
Brugia malayi nuclear receptor RXR 0.0175 0.1926 0.4025
Schistosoma mansoni cytochrome P450 0.0026 0.0172 0.036
Loa Loa (eye worm) steroid hormone receptor 0.0371 0.4227 0.8835
Schistosoma mansoni hypothetical protein 0.0021 0.0117 0.0245
Loa Loa (eye worm) hypothetical protein 0.0025 0.0169 0.0353
Schistosoma mansoni rab6-interacting 0.0021 0.0117 0.0245
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0261 0.1283
Loa Loa (eye worm) hypothetical protein 0.0371 0.4227 0.8835
Loa Loa (eye worm) hypothetical protein 0.0033 0.026 0.0544
Echinococcus multilocularis neuropeptide s receptor 0.0448 0.5137 0.5137
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0175 0.1926 0.1926
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0206 0.1014
Brugia malayi prolyl oligopeptidase family protein 0.0418 0.4784 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.1133 0.2369
Loa Loa (eye worm) hypothetical protein 0.0371 0.4227 0.8835
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0175 0.1926 0.4025
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0156 0.6004
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0175 0.1926 0.3749
Schistosoma mansoni netrin receptor unc5 0.0015 0.005 0.0105
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0381 0.0796
Brugia malayi nuclear receptor NHR-67 0.0175 0.1926 0.4025
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0371 0.4227 0.8835
Loa Loa (eye worm) cytochrome P450 0.0026 0.0172 0.036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0203 0.0997
Loa Loa (eye worm) hypothetical protein 0.0337 0.3834 0.8013
Onchocerca volvulus 0.0175 0.1926 0.4025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0206 0.1014
Loa Loa (eye worm) hypothetical protein 0.0033 0.026 0.0544
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.026 0.6023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0196 0.041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0288 0.1417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0371 0.4227 0.8835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0371 0.4227 0.8835
Onchocerca volvulus Prolyl endopeptidase homolog 0.0033 0.026 0.0544
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0432 0.0846
Onchocerca volvulus Bile acid receptor homolog 0.0371 0.4227 0.8835
Brugia malayi hypothetical protein 0.0021 0.0117 0.0245
Loa Loa (eye worm) hypothetical protein 0.0175 0.1926 0.4025
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0318 0.0586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0174 0.0855
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.005 0.0105
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0117 0.0228
Brugia malayi Nuclear hormone receptor E75 0.0175 0.1926 0.4025
Loa Loa (eye worm) hypothetical protein 0.0175 0.1926 0.4025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0059 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0059 0.0291
Echinococcus granulosus ecdysone induced protein 78C 0.0371 0.4227 0.8229
Echinococcus granulosus death domain containing protein 0.0015 0.005 0.0098
Schistosoma mansoni nuclear hormone receptor 0.0175 0.1926 0.4025
Loa Loa (eye worm) hypothetical protein 0.0371 0.4227 0.8835
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0156 0.1026
Schistosoma mansoni hypothetical protein 0.0015 0.0049 0.0103
Plasmodium vivax hypothetical protein, conserved 0.0033 0.026 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0033 0.026 0.1279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0288 0.1417
Plasmodium falciparum peptidase, putative 0.0033 0.026 1
Onchocerca volvulus 0.0098 0.1018 0.2127
Echinococcus multilocularis 0.0026 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0025 0.0169 0.0353
Onchocerca volvulus 0.0055 0.0513 0.1072
Schistosoma mansoni lamin 0.0055 0.0513 0.1072
Loa Loa (eye worm) hypothetical protein 0.0055 0.0513 0.1072
Brugia malayi nuclear receptor RXR 0.0196 0.2172 0.454
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0055 0.0512 0.3006
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0141 0.1523 0.3318
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0889 0.1857
Brugia malayi intermediate filament protein 0.0055 0.0513 0.1072
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.026 0.0456
Loa Loa (eye worm) DR-78 0.0175 0.1926 0.4025
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0141 0.1523 0.3318
Loa Loa (eye worm) nuclear receptor NHR-67 0.0175 0.1926 0.4025
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0435 0.091
Echinococcus granulosus FTZ F1 alpha 0.0371 0.4227 0.8229
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0136 0.0175
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.026 0.0544
Leishmania major cytochrome p450-like protein 0.0026 0.0172 0.0256
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0371 0.4227 0.8229
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0215 0.0449
Schistosoma mansoni steroid hormone receptor ad4bp 0.0371 0.4227 0.8835
Brugia malayi SET domain containing protein 0.0012 0.0007 0.0015
Onchocerca volvulus Netrin receptor homolog 0.0015 0.005 0.0105
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0033 0.026 0.0779
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0381 0.0796
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0019 0.0039
Schistosoma mansoni lipoxygenase 0.0088 0.0901 0.1883
Loa Loa (eye worm) CYP4Cod1 0.0043 0.0381 0.0796
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0049 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0174 0.0853
Echinococcus granulosus voltage gated potassium channel 0.0015 0.0044 0.0085
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0049 0.0096
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0432 0.0903
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0318 0.0586
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0033 0.026 0.0456
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.026 0.6023
Loa Loa (eye worm) hypothetical protein 0.0175 0.1926 0.4025
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0371 0.4227 0.8835
Echinococcus granulosus Nuclear hormone receptor HR96 0.0175 0.1926 0.3749
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0513 0.1072
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0117 0.0117
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0435 0.091
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0098 0.1018 0.2127
Leishmania major cytochrome p450-like protein 0.0026 0.0172 0.0256
Loa Loa (eye worm) hypothetical protein 0.0196 0.2172 0.454
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0889 0.1857
Brugia malayi hypothetical protein 0.0098 0.1019 0.213
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0371 0.4227 0.4227
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0371 0.4227 0.8835
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0245
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0418 0.4784 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0049 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.004 0.0194
Toxoplasma gondii histone lysine methyltransferase SET1 0.0052 0.0487 0.3198
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0074 0.0362
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0074 0.0362
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0059 0.0115
Brugia malayi nuclear receptor NHR-88 0.0371 0.4227 0.8835
Brugia malayi prolyl oligopeptidase family protein 0.0141 0.1523 0.3183
Schistosoma mansoni rab6-interacting 0.0021 0.0117 0.0245
Brugia malayi nuclear hormone receptor 0.0175 0.1926 0.4025
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0105
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0005 0.0011
Echinococcus granulosus lamin dm0 0.0055 0.0513 0.0999
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0125 0.1344 0.1344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0174 0.0853
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0175 0.1926 0.4025
Brugia malayi nuclear hormone receptor family member odr-7 0.0175 0.1926 0.4025
Echinococcus granulosus cpg binding protein 0.0029 0.0215 0.0418
Brugia malayi Cytochrome P450 family protein 0.0043 0.0381 0.0796
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0288 0.1417
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0059 0.0124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0074 0.0362
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0117 0.4501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0317 0.1559
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0059 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.0371 0.4227 0.8835
Schistosoma mansoni lamin 0.0055 0.0513 0.1072
Echinococcus granulosus sodium channel protein 0.0071 0.0701 0.1365
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0392 0.447 1
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0379 0.0792
Echinococcus multilocularis acylamino acid releasing enzyme 0.0033 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0175 0.1926 0.4025
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.026 0.0456
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.026 0.0544
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0196 0.2172 0.454
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0156 0.022
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0175 0.1926 0.4025
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0432 0.0903
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0033 0.026 0.1227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0432 0.2124
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0513 0.1072
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0033 0.026 0.0456
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0371 0.4227 0.4227
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.005 0.005
Trypanosoma cruzi prolyl endopeptidase 0.0033 0.026 0.0456
Loa Loa (eye worm) nuclear hormone receptor 0.0175 0.1926 0.4025
Schistosoma mansoni loxhd1 0.0021 0.0117 0.0245
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0432 0.0846
Schistosoma mansoni coup transcription factor 0.0371 0.4227 0.8835
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0044 0.0092
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0418 0.4784 1
Schistosoma mansoni nuclear receptor nhr-48 0.0175 0.1926 0.4025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0285 0.0596
Brugia malayi steroid hormone receptor 0.0371 0.4227 0.8835
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0288 0.1894
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.026 0.0544
Loa Loa (eye worm) hypothetical protein 0.0175 0.1926 0.4025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0175 0.1926 0.3749
Echinococcus granulosus netrin receptor unc 5 0.0015 0.005 0.0098
Onchocerca volvulus 0.0175 0.1926 0.4025
Echinococcus multilocularis nuclear receptor nhr 48 0.0175 0.1926 0.1926
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.005 0.005
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.026 0.6023
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0196 0.2172 0.2172
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0371 0.4227 0.8835
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0318 0.0586
Onchocerca volvulus 0.0028 0.0196 0.041
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0005 0.0027
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0005 0.0011
Brugia malayi nuclear hormone receptor 0.0371 0.4227 0.8835
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0156 0.022
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0005 0.0011
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0432 1
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0117 0.0228
Echinococcus multilocularis cpg binding protein 0.0029 0.0215 0.0215
Echinococcus granulosus Nuclear hormone receptor HR96 0.0175 0.1926 0.3749
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0371 0.4227 0.8229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0288 0.1417
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0087 0.0889 0.173
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0071 0.0701 0.1456
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0418 0.4784 0.9314
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0141 0.1523 0.3318
Brugia malayi Nuclear hormone receptor-like 1 0.0196 0.2172 0.454
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0371 0.4227 0.8835
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.0105
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0019 0.0019
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0215 0.0449
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0371 0.4227 0.8835
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0371 0.4227 0.8835
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0005 0.0011
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0141 0.1523 1
Trypanosoma cruzi oligopeptidase b 0.0033 0.026 0.0456
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.005 0.0105
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0117 0.0245
Treponema pallidum quinoline 2-oxidoreductase 0.0029 0.0215 0.8682
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0257 0.0537
Loa Loa (eye worm) hypothetical protein 0.0175 0.1926 0.4025
Onchocerca volvulus 0.0012 0.0007 0.0015
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.026 0.6023
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0175 0.1926 0.1926
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0141 0.1523 0.1523
Echinococcus granulosus cytochrome P450 2K1 0.0026 0.0172 0.0335
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0168
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0175 0.1926 0.1926
Schistosoma mansoni hypothetical protein 0.0015 0.0049 0.0103
Echinococcus granulosus acylamino acid releasing enzyme 0.0033 0.026 0.0507
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0026 0.0172 0.0256
Trichomonas vaginalis aldehyde oxidase, putative 0.0184 0.2035 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0019 0.0039
Onchocerca volvulus 0.0021 0.0117 0.0245
Brugia malayi Death domain containing protein 0.0015 0.005 0.0105
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0019 0.0036
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0435 0.091
Schistosoma mansoni cpg binding protein 0.0029 0.0215 0.0449
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0044 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0203 0.0997
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0196 0.2172 0.454
Loa Loa (eye worm) hypothetical protein 0.0371 0.4227 0.8835
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0071 0.0701 0.1365
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0371 0.4227 0.8835
Loa Loa (eye worm) hypothetical protein 0.02 0.2222 0.4644
Trypanosoma cruzi oligopeptidase b 0.0033 0.026 0.0456
Brugia malayi hypothetical protein 0.0196 0.2172 0.454
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0791 0.0791
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0371 0.4227 0.8835
Brugia malayi nuclear hormone receptor family member nhr-6 0.0175 0.1926 0.4025
Brugia malayi hypothetical protein 0.0175 0.1926 0.4025
Echinococcus granulosus neuropeptide s receptor 0.0448 0.5137 1
Echinococcus granulosus GPCR family 2 0.0015 0.0049 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0371 0.4227 0.8835
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0175 0.1926 0.4025
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0371 0.4227 0.4227
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.026 0.0544
Echinococcus multilocularis musashi 0.0055 0.0513 0.0513
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0371 0.4227 0.8835
Brugia malayi Cyclic-nucleotide gated cation channel 0.0011 0.0005 0.0011
Brugia malayi Cytochrome P450 family protein 0.0043 0.0381 0.0796
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0141 0.1523 0.3183
Echinococcus granulosus intermediate filament protein 0.0055 0.0513 0.0999
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.005 0.0098
Loa Loa (eye worm) hypothetical protein 0.0175 0.1926 0.4025
Giardia lamblia GTOR 0.0048 0.0432 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0059 0.0291
Brugia malayi Steroid receptor seven-up type 2 0.0371 0.4227 0.8835
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0432 0.0432
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0513 0.1072
Loa Loa (eye worm) hypothetical protein 0.0054 0.0501 0.1048
Echinococcus multilocularis neuropeptide receptor A26 0.0448 0.5137 0.5137
Brugia malayi hypothetical protein 0.0129 0.1391 0.2908
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0261 0.1283
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.005 0.0105
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0074 0.0362
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0175 0.1926 0.1926
Mycobacterium ulcerans hypothetical protein 0.003 0.0223 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0317 0.1559
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0371 0.4227 0.8229
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0033 0.026 0.0456
Brugia malayi Doublecortin family protein 0.0021 0.0117 0.0245
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0035 0.0284 0.1558
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0005 0.0011
Echinococcus granulosus lamin 0.0055 0.0513 0.0999
Mycobacterium tuberculosis Probable peptidase 0.0033 0.026 0.1227
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0432 0.0846
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0074 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0371 0.4227 0.8835
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0043 0.0381 0.1842
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0432 0.2124
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0381 0.0729
Brugia malayi photoreceptor-specific nuclear receptor 0.0371 0.4227 0.8835
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0175 0.1926 0.4025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0371 0.4227 0.8835
Echinococcus multilocularis GPCR, family 2 0.0015 0.0049 0.0049
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0371 0.4227 0.4227
Schistosoma mansoni hypothetical protein 0.0015 0.0049 0.0103
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0432 0.0846
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0432 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0005 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0174 0.0855
Loa Loa (eye worm) hypothetical protein 0.0175 0.1926 0.4025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0247 0.1216
Onchocerca volvulus 0.0371 0.4227 0.8835
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0371 0.4227 0.8835
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0175 0.1926 0.4025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0206 0.1014
Schistosoma mansoni nuclear receptor 0.0175 0.1926 0.4025
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0141 0.1523 0.3318
Echinococcus multilocularis Ankyrin 0.0015 0.0052 0.0052
Brugia malayi hypothetical protein 0.0196 0.2172 0.454
Trypanosoma brucei oligopeptidase b 0.0033 0.026 0.0456
Trypanosoma brucei prolyl oligopeptidase, putative 0.0033 0.026 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.035 0.172
Trypanosoma brucei C-8 sterol isomerase, putative 0.0392 0.447 1
Brugia malayi ecdysone receptor 0.0175 0.1926 0.4025
Loa Loa (eye worm) hypothetical protein 0.0196 0.2172 0.454
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0371 0.4227 0.8835
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0418 0.4784 0.4784
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0005 0.0011
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0052 0.0109
Echinococcus granulosus nuclear receptor nhr 48 0.0175 0.1926 0.3749
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0371 0.4227 0.8835
Brugia malayi hypothetical protein 0.0021 0.0117 0.0245
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0005 0.0011
Schistosoma mansoni zinc finger protein 0.0175 0.1926 0.4025
Echinococcus multilocularis thyroid hormone receptor alpha 0.0371 0.4227 0.4227
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0117 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0432 0.2124
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0117 0.0117
Brugia malayi Nuclear hormone receptor E75 0.0175 0.1926 0.4025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0174 0.0855
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0381 0.0729
Brugia malayi Uncoordinated protein 44 0.0015 0.005 0.0105
Brugia malayi CXXC zinc finger family protein 0.0028 0.0196 0.041
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0117 0.4501
Loa Loa (eye worm) hypothetical protein 0.0024 0.0156 0.0327
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0011 0.0005 0.0011
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0015 0.0044 0.0092
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0005 0.0005
Echinococcus multilocularis Chromobox protein 3 0.0011 0.00000002929 0.00000002929
Brugia malayi nuclear receptor NHR-88 0.0175 0.1926 0.4025
Schistosoma mansoni polycystin 1-related 0.0021 0.0117 0.0245
Leishmania major C-8 sterol isomerase-like protein 0.0392 0.447 1
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0062 0.0602 0.5972
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0156 0.6004
Echinococcus multilocularis FTZ F1 alpha 0.0371 0.4227 0.4227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0059 0.0291
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0033 0.026 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0103
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.026 0.6023
Loa Loa (eye worm) hypothetical protein 0.0371 0.4227 0.8835
Schistosoma mansoni hypothetical protein 0.0026 0.0172 0.036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0074 0.0362
Brugia malayi Cytochrome P450 family protein 0.0085 0.0865 0.1807
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0371 0.4227 0.8229
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0371 0.4227 0.8835
Brugia malayi orphan nuclear receptor NR2E1 0.0175 0.1926 0.4025
Echinococcus granulosus thyroid hormone receptor alpha 0.0175 0.1926 0.3749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0288 0.1417
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0341 0.0712
Echinococcus multilocularis lamin dm0 0.0055 0.0513 0.0513
Brugia malayi Protein kinase domain containing protein 0.0015 0.005 0.0105
Onchocerca volvulus 0.0098 0.1018 0.2127
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0125 0.1344 0.2617
Loa Loa (eye worm) hypothetical protein 0.0175 0.1926 0.4025
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0015 0.0044 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0156 0.022
Echinococcus multilocularis dnaJ subfamily B 0.0394 0.4502 0.4502
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0371 0.4227 0.8835
Loa Loa (eye worm) hypothetical protein 0.0015 0.0052 0.0109
Trypanosoma brucei cytochrome P450, putative 0.0043 0.0381 0.0729
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0117 0.0228
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0062 0.0602 0.3793
Loa Loa (eye worm) hypothetical protein 0.0196 0.2172 0.454
Loa Loa (eye worm) hypothetical protein 0.0371 0.4227 0.8835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0235 0.1156
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0011
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0005 0.0011
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0087 0.0891 0.6351
Echinococcus multilocularis lamin 0.0055 0.0513 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0288 0.1417
Schistosoma mansoni retinoic acid receptor RXR 0.0371 0.4227 0.8835
Brugia malayi Cytochrome P450 family protein 0.0026 0.0172 0.036
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0026 0.0172 0.0256
Trypanosoma brucei prolyl endopeptidase 0.0033 0.026 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0317 0.1559
Loa Loa (eye worm) hypothetical protein 0.0371 0.4227 0.8835
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0371 0.4227 0.8835
Loa Loa (eye worm) hypothetical protein 0.0048 0.0435 0.091
Loa Loa (eye worm) prolyl oligopeptidase 0.0033 0.026 0.0544
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0049 0.0049
Schistosoma mansoni RAR-like nuclear receptor 0.0371 0.4227 0.8835
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0371 0.4227 0.8835
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0033 0.026 0.0456
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0049 0.0103
Brugia malayi Nuclear hormone receptor-like 1 0.0196 0.2172 0.454

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.92 nmol/L Inhibition of DPP4 in human plasma by fluorescence assay ChEMBL. 17317162
IC50 (binding) = 0.92 nmol/L Inhibition of DPP4 in human plasma by fluorescence assay ChEMBL. 17317162
IC50 (binding) = 0.92 nmol/L Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry ChEMBL. 22824762
IC50 (binding) = 1.1 nmol/L Inhibition of DPP4 in rat plasma by fluorescence assay ChEMBL. 17317162
IC50 (binding) = 1.1 nmol/L Inhibition of DPP4 in rat plasma by fluorescence assay ChEMBL. 17317162
IC50 (binding) = 1.1 nmol/L Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry ChEMBL. 22824762
Inhibition (functional) = 60 % Inhibition of DPP4 in Wistar rat plasma at 10 umol/kg, po after 9 hrs ChEMBL. 17317162
Inhibition (functional) = 95 % Inhibition of DPP4 in Wistar rat plasma at 10 umol/kg, po within 30 mins ChEMBL. 17317162

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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