Detailed information for compound 455144

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 473.607 | Formula: C29H35N3O3
  • H donors: 1 H acceptors: 4 LogP: 6.07 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cnc(nc1N(CCCOc1ccc2c(c1)CC[C@H]2CC(=O)O)C)c1ccc(cc1)CC
  • InChi: 1S/C29H35N3O3/c1-4-20-7-9-22(10-8-20)28-30-19-21(5-2)29(31-28)32(3)15-6-16-35-25-13-14-26-23(17-25)11-12-24(26)18-27(33)34/h7-10,13-14,17,19,24H,4-6,11-12,15-16,18H2,1-3H3,(H,33,34)/t24-/m0/s1
  • InChiKey: NVYFLRDURLXFRQ-DEOSSOPVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peroxisome proliferator-activated receptor delta Starlite/ChEMBL References
Homo sapiens peroxisome proliferator-activated receptor alpha Starlite/ChEMBL References
Mus musculus peroxisome proliferator activated receptor gamma Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative Get druggable targets OG5_137778 All targets in OG5_137778
Schistosoma japonicum IPR008946,Nuclear receptor, ligand-binding,domain-containing Get druggable targets OG5_137778 All targets in OG5_137778
Schistosoma mansoni nuclear hormone receptor superfamily protein-related Get druggable targets OG5_137778 All targets in OG5_137778
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor peroxisome proliferator activated receptor gamma 475 aa 395 aa 26.3 %
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor alpha 468 aa 397 aa 25.4 %
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor delta 441 aa 369 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0035 0.0272
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0074 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0227 0.3343
Brugia malayi nuclear receptor RXR 0.0029 0.0072 0.1048
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0373 0.0371
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0336 1
Schistosoma mansoni microtubule-associated protein tau 0.0726 0.4264 0.4264
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0026 0.0054 0.0054
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0336 0.1297
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.016 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0027 0.0098
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0017 0.0002 0.0008
Entamoeba histolytica hypothetical protein 0.0075 0.0351 0.1358
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0035 0.0128
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0059 0.4526
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0029
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0011 0.0038
Loa Loa (eye worm) hypothetical protein 0.0073 0.0336 0.1301
Echinococcus multilocularis tar DNA binding protein 0.0037 0.0118 0.0117
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0127 0.3269
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0127 0.0126
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0011 0.071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0227 0.3343
Brugia malayi mbt repeat family protein 0.0051 0.0206 0.3024
Loa Loa (eye worm) steroid hormone receptor 0.0055 0.0227 0.088
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0026 0.0054 0.0052
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0054 0.0845
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.004 0.0039
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0385 0.0385
Brugia malayi jmjC domain containing protein 0.007 0.0318 0.4681
Schistosoma mansoni DNA polymerase eta 0.0044 0.016 0.016
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0227 0.0227
Echinococcus granulosus Diacylglycerol kinase theta 0.0017 0.0002 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0227 0.0226
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0385 0.0384
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.016 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0227 0.3343
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0017 0.0002 0.0008
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0203
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0442 0.256 0.256
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0059 0.4526
Toxoplasma gondii exonuclease III APE 0.0038 0.0127 0.1015
Brugia malayi mbt repeat family protein 0.0051 0.0206 0.3024
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0336 0.1297
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0248 0.0247
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0127 0.0486
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0027 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0055 0.0227 0.3343
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0027 0.0376
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0206 0.0206
Echinococcus multilocularis FTZ F1 alpha 0.0055 0.0227 0.0226
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0054 0.0773
Schistosoma mansoni hypothetical protein 0.0184 0.1005 0.1005
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0278 0.0276
Loa Loa (eye worm) hypothetical protein 0.0081 0.0385 0.1493
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0678 0.2632
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0336 0.8987
Loa Loa (eye worm) hypothetical protein 0.0055 0.0227 0.088
Toxoplasma gondii hypothetical protein 0.0027 0.0062 0.0486
Loa Loa (eye worm) hypothetical protein 0.0055 0.0227 0.088
Schistosoma mansoni ferritin 0.0018 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0227 0.3343
Schistosoma mansoni mixed-lineage leukemia protein mll 0.025 0.1403 0.1403
Schistosoma mansoni apoferritin-2 0.0018 0.0008 0.0008
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0055 0.0227 0.0226
Echinococcus granulosus dna polymerase eta 0.0044 0.016 0.0159
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0026 0.0054 0.0052
Onchocerca volvulus 0.0021 0.0027 0.0402
Onchocerca volvulus Protein ultraspiracle homolog 0.0055 0.0227 0.3719
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0011 0.0619
Echinococcus granulosus Diacylglycerol kinase zeta 0.0017 0.0002 0.0001
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0026 0.0054 0.0773
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0074 0.0073
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0336 0.4944
Brugia malayi hypothetical protein 0.0029 0.0072 0.1048
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0072 0.1048
Schistosoma mansoni nuclear receptor 0.0026 0.0054 0.0054
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0035 0.0739
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0055 0.0227 0.088
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0336 0.4944
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0248 0.0247
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0127 0.0486
Echinococcus granulosus expressed protein 0.0018 0.0008 0.0007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0074 0.0073
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0011 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0194 0.0194
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0027 0.0095
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0011 0.071
Brugia malayi ecdysone receptor 0.0026 0.0054 0.0773
Loa Loa (eye worm) nuclear receptor NHR-67 0.0026 0.0054 0.0203
Echinococcus granulosus sphingosine kinase 1 0.0444 0.2572 0.2571
Entamoeba histolytica hypothetical protein 0.0075 0.0351 0.1358
Onchocerca volvulus 0.0055 0.0227 0.3719
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0278 0.0276
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0011 0.0035
Echinococcus granulosus FTZ F1 alpha 0.0055 0.0227 0.0226
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0027 0.0095
Loa Loa (eye worm) RNA binding protein 0.0037 0.0118 0.0456
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0373 0.1441
Brugia malayi isocitrate dehydrogenase 0.0017 0.0001 0.0002
Onchocerca volvulus 0.0021 0.0027 0.0402
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0203
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0027 0.159
Schistosoma mansoni sphingosine kinase A B 0.0444 0.2572 0.2572
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0055 0.0227 0.3343
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.0072 0.0276
Echinococcus granulosus ferritin 0.0018 0.0008 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0027 0.0376
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0059 0.4526
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0017 0.0002 0.0002
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0027 0.0505
Loa Loa (eye worm) nuclear hormone receptor 0.0026 0.0054 0.0203
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0194 0.0748
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0011 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0194 0.0194
Brugia malayi nuclear hormone receptor 0.0026 0.0054 0.0773
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0209 0.0808
Brugia malayi hypothetical protein 0.0029 0.0072 0.1048
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0027 0.0098
Schistosoma mansoni hypothetical protein 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0121 0.0465
Loa Loa (eye worm) TAR-binding protein 0.0037 0.0118 0.0456
Loa Loa (eye worm) hypothetical protein 0.0054 0.0225 0.0871
Echinococcus multilocularis cpg binding protein 0.0125 0.0648 0.0647
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0095
Echinococcus multilocularis ferritin 0.0018 0.0008 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0027 0.0376
Echinococcus multilocularis sphingosine kinase 1 0.0444 0.2572 0.2571
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0008 0.0027
Brugia malayi TAR-binding protein 0.0037 0.0118 0.1732
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0027 0.0376
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0027 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0059 0.4526
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0035 0.0272
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0009 0.0029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0099
Brugia malayi tailless protein 0.0026 0.0054 0.0773
Brugia malayi nuclear receptor NHR-88 0.0026 0.0054 0.0773
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0194 0.0192
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0027 0.0098
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0127 0.3393
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0059 0.4526
Loa Loa (eye worm) hypothetical protein 0.0073 0.0336 0.1301
Trypanosoma brucei Sphingosine kinase 0.0017 0.0002 0.0061
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0278 0.0276
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0054 0.0052
Leishmania major DNA polymerase kappa, putative 0.0019 0.0011 0.0295
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0373 0.1441
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0055 0.0227 0.0226
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0026 0.0054 0.0052
Leishmania major diacylglycerol kinase, putative 0.0017 0.0002 0.0029
Onchocerca volvulus 0.0081 0.0385 0.6325
Brugia malayi diacylglycerol kinase 0.0017 0.0002 0.0017
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0373 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0027 0.0098
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0083 0.0654
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0017 0.0002 0.0061
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0127 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0037 0.0118 0.0456
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0227 0.3343
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.0319 0.1814 0.1814
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0017 0.0002 0.0061
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0027 0.0095
Brugia malayi nuclear receptor RXR 0.0026 0.0054 0.0773
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0385 0.5674
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0095
Schistosoma mansoni hypothetical protein 0.1679 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0207 0.0801
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0059 0.4526
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0001 0.0001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0127 1
Brugia malayi Steroid receptor seven-up type 2 0.0055 0.0227 0.3343
Schistosoma mansoni zinc finger protein 0.0026 0.0054 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0059 0.4526
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0054 0.0052
Brugia malayi RNA binding protein 0.0037 0.0118 0.1732
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0017 0.0002 0.0001
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0027 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0059 0.4526
Loa Loa (eye worm) hypothetical protein 0.0051 0.0206 0.0796
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0017 0.0002 0.0004
Schistosoma mansoni steroid hormone receptor ad4bp 0.0055 0.0227 0.0227
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0002 0.0061
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0225 0.6026
Schistosoma mansoni hypothetical protein 0.0184 0.1005 0.1005
Brugia malayi ecdysteroid receptor 0.0055 0.0227 0.3343
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0055 0.0227 0.3343
Entamoeba histolytica hypothetical protein 0.0075 0.0351 0.1358
Loa Loa (eye worm) diacylglycerol kinase 2 0.0017 0.0002 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0072 0.0072
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0027 0.0095
Echinococcus multilocularis microtubule associated protein 2 0.0726 0.4264 0.4264
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0055 0.0227 0.3343
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0001 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0227 0.0226
Echinococcus granulosus tar DNA binding protein 0.0037 0.0118 0.0117
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0055 0.0227 0.0227
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0027 0.159
Schistosoma mansoni apoferritin-2 0.0018 0.0008 0.0008
Echinococcus multilocularis geminin 0.0184 0.1005 0.1004
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0011 0.0619
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0054 0.0052
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0027 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0027 0.0681
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0121 0.1767
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0095
Loa Loa (eye worm) hypothetical protein 0.0444 0.2572 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0055 0.0227 0.088
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0027 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0203
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0062 0.1466
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0127 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0206 0.0206
Schistosoma mansoni retinoic acid receptor RXR 0.0055 0.0227 0.0227
Brugia malayi Ceramide kinase 0.0017 0.0002 0.0017
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0027 0.1945
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0055 0.0227 0.0227
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0035 0.091
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0206 0.0205
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0203
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0027 0.0376
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0083 0.5099
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Echinococcus multilocularis dna polymerase eta 0.0044 0.016 0.0159
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0276
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0127 0.0126
Plasmodium vivax diacylglycerol kinase, putative 0.0017 0.0002 0.0026
Echinococcus multilocularis ecdysone induced protein 78C 0.0055 0.0227 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0027 0.159
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0336 0.1297
Loa Loa (eye worm) hypothetical protein 0.0044 0.016 0.0619
Brugia malayi nuclear hormone receptor family member odr-7 0.0026 0.0054 0.0773
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0059 0.4526
Loa Loa (eye worm) hypothetical protein 0.0079 0.0373 0.1445
Loa Loa (eye worm) hypothetical protein 0.0054 0.0225 0.0871
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0194 0.0192
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0373 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0351 0.035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0336 0.1301
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0059 0.4526
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0017 0.0002 0.0001
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0248 0.3653
Schistosoma mansoni cpg binding protein 0.0125 0.0648 0.0648
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0035 0.0739
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0027 0.0204
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0027 0.0756
Onchocerca volvulus 0.0026 0.0054 0.0845
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0318 0.1232
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0035 0.2124
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0027 0.0099
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0209 0.0208
Echinococcus granulosus dna polymerase kappa 0.0019 0.0011 0.001
Schistosoma mansoni ferritin 0.0018 0.0008 0.0008
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.004 0.0039
Brugia malayi Diacylglycerol kinase protein 2 0.0017 0.0002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0203
Schistosoma mansoni hypothetical protein 0.0017 0.0001 0.0001
Echinococcus multilocularis nuclear receptor nhr 48 0.0026 0.0054 0.0052
Schistosoma mansoni hypothetical protein 0.0017 0.0001 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.016 0.2353
Echinococcus granulosus thyroid hormone receptor alpha 0.0026 0.0054 0.0052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0227 0.3343
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0099
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0224 0.3289
Brugia malayi nuclear receptor NHR-67 0.0026 0.0054 0.0773
Mycobacterium tuberculosis Conserved protein 0.0444 0.2572 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0227 0.0226
Schistosoma mansoni ap endonuclease 0.0038 0.0127 0.0127
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0248 0.0248
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0027 0.0025
Plasmodium vivax diacylglycerol kinase, putative 0.0017 0.0002 0.0026
Plasmodium falciparum diacylglycerol kinase, putative 0.0017 0.0002 0.0026
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.0072 0.0071
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0225 0.6026
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0054 0.0054
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0011 0.0011
Trypanosoma brucei diacylglycerol kinase, putative 0.0017 0.0002 0.0061
Schistosoma mansoni cpg binding protein 0.0125 0.0648 0.0648
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0318 0.0318
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0035 0.0739
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0224 0.0866
Echinococcus multilocularis expressed protein 0.0018 0.0008 0.0007
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0054 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0127 0.049
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0336 0.8987
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0127 0.1864
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0373 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0004
Brugia malayi nuclear hormone receptor family member nhr-6 0.0026 0.0054 0.0773
Schistosoma mansoni tar DNA-binding protein 0.0037 0.0118 0.0118
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0002 0.0061
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0072 0.1048
Echinococcus granulosus ecdysone induced protein 78C 0.0055 0.0227 0.0226
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0318 0.0318
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0035 0.091
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0055 0.0227 0.0226
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0207 0.0801
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0373 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0248 0.0961
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0017 0.0002 0.0061
Echinococcus granulosus cpg binding protein 0.0125 0.0648 0.0647
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0373 0.2992
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0248 0.0247
Loa Loa (eye worm) hypothetical protein 0.0055 0.0227 0.088
Schistosoma mansoni ap endonuclease 0.0038 0.0127 0.0127
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0206 0.0796
Brugia malayi RNA recognition motif domain containing protein 0.0037 0.0118 0.1732
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0027 0.0095
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0011 0.0039
Brugia malayi orphan nuclear receptor NR2E1 0.0026 0.0054 0.0773
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0336 1
Onchocerca volvulus 0.0026 0.0054 0.0845
Trypanosoma cruzi Sphingosine kinase 0.0017 0.0002 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0095
Onchocerca volvulus 0.0021 0.0027 0.0402
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0062 0.1466
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0095
Brugia malayi diacylglycerol kinase 0.0017 0.0002 0.0017
Onchocerca volvulus 0.0021 0.0027 0.0402
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0055 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0054 0.0225 0.0871
Echinococcus granulosus microtubule associated protein 2 0.0726 0.4264 0.4264
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0055 0.0227 0.0226
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0373 0.2992
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0027 0.0098
Brugia malayi conserved hypotetical protein 0.0026 0.0054 0.0773
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0055 0.0227 0.0226
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0027 0.159
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0027 0.1945
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0027 0.0095
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0276
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0206 0.0205
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0278 0.0278
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0054 0.0054
Loa Loa (eye worm) ceramide kinase 0.0017 0.0002 0.0004
Entamoeba histolytica hypothetical protein 0.0075 0.0351 0.1358
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0054 0.0845
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0276
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0027 0.0098
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0385 0.0384
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0127 0.3393
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0055 0.0227 0.3343
Loa Loa (eye worm) DR-78 0.0026 0.0054 0.0203
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0062 0.1624
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0011 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0059 0.4526
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0074 0.0074
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0127 0.3269
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0203
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0027 0.159
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0276
Echinococcus multilocularis dnaJ subfamily B 0.1679 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0118 0.0116
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0055 0.0227 0.0226
Trypanosoma cruzi Sphingosine kinase 0.0017 0.0002 0.0061
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0035 0.101
Schistosoma mansoni RAR-like nuclear receptor 0.0055 0.0227 0.0227
Brugia malayi hypothetical protein 0.0075 0.0351 0.5176
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0008 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0055 0.0227 0.088
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.0072 0.0072
Brugia malayi jmjC domain containing protein 0.0063 0.0278 0.4083
Trypanosoma cruzi diacylglycerol kinase, putative 0.0017 0.0002 0.0061
Loa Loa (eye worm) hypothetical protein 0.0054 0.0225 0.0871
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0209 0.0208
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0336 0.1297
Schistosoma mansoni hypothetical protein 0.0075 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0054 0.0224 0.0866
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0027 0.0505
Schistosoma mansoni nuclear receptor nhr-48 0.0026 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0276
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0227 0.0227
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0207 0.0801
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0248 0.0247
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0035 0.0131
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0336 0.1301
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0027 0.0756
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0203
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0027 0.0095
Toxoplasma gondii histone lysine methyltransferase SET1 0.0223 0.1242 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0194 0.2843
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0203
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0206 0.3362
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0027 0.0098
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.0072 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0055 0.0227 0.3343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0055 0.0227 0.088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0203
Loa Loa (eye worm) hypothetical protein 0.0055 0.0227 0.088
Loa Loa (eye worm) hypothetical protein 0.0055 0.0227 0.088
Schistosoma mansoni ferritin 0.0018 0.0008 0.0008
Schistosoma mansoni sphingoid long chain base kinase 0.0444 0.2572 0.2572
Echinococcus granulosus ceramide kinase 0.0017 0.0002 0.0001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0062 0.1624
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.1157 0.1155
Echinococcus multilocularis Diacylglycerol kinase theta 0.0017 0.0002 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0194 0.0192
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0027 0.0025
Brugia malayi steroid hormone receptor 0.0055 0.0227 0.3343
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0011 0.0011
Echinococcus granulosus nuclear receptor nhr 48 0.0026 0.0054 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0059 0.4526
Schistosoma mansoni ferritin 0.0018 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0055 0.0227 0.3343
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0055 0.0227 0.3719
Entamoeba histolytica hypothetical protein, conserved 0.0444 0.2572 1
Schistosoma mansoni hypothetical protein 0.0017 0.0001 0.0001
Onchocerca volvulus 0.0073 0.0336 0.5508
Trichomonas vaginalis helicase, putative 0.0027 0.0059 0.4526
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Brugia malayi nuclear hormone receptor 0.0055 0.0227 0.3343
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0026 0.0054 0.0203
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0373 0.0373
Schistosoma mansoni diacylglycerol kinase theta 0.0017 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0055 0.0227 0.088
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0373 0.0371
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0227 0.0227
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0011 0.0148
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0351 0.035
Brugia malayi MH2 domain containing protein 0.013 0.0678 1
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0017 0.0002 0.0001
Trichomonas vaginalis ferritin, putative 0.0018 0.0008 0.0471
Echinococcus multilocularis ceramide kinase 0.0017 0.0002 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0055 0.0227 0.088
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0055 0.0227 0.0226
Loa Loa (eye worm) oxidoreductase 0.0021 0.0027 0.0099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0027 0.0098
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0206 0.0205
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0373 1
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0054 0.0773
Mycobacterium tuberculosis Diacylglycerol kinase 0.0017 0.0002 0.0004
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0027 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0037 0.0118 0.0118
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0054 0.0052
Plasmodium falciparum diacylglycerol kinase, putative 0.0017 0.0002 0.0026
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.1157 0.1155
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0055 0.0227 0.0227
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0029
Leishmania major DNA polymerase eta, putative 0.0031 0.0083 0.2425
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0225 0.0867
Schistosoma mansoni coup transcription factor 0.0055 0.0227 0.0227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0194 0.0194
Schistosoma mansoni tar DNA-binding protein 0.0037 0.0118 0.0118
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0209 0.5514
Brugia malayi hypothetical protein 0.0017 0.0002 0.0017
Mycobacterium ulcerans hypothetical protein 0.0073 0.0336 0.1297
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0336 0.1297
Brugia malayi Probable ClpP-like protease 0.0079 0.0373 0.5489
Schistosoma mansoni hypothetical protein 0.0037 0.0121 0.0121
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0224 0.3289
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0336 0.1297
Brugia malayi hypothetical protein 0.0026 0.0054 0.0773
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0227 0.0227
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0055 0.0227 0.0226
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0227 0.0226
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0336 0.1297
Leishmania major sphingosine kinase A, B, putative 0.0017 0.0002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0055 0.0227 0.088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0127 0.7921
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0373 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0027 0.0756
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0118 0.0453
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0027 0.159
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0203
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0853 0.5029 0.5028
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0118 0.0116
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0373 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0011 0.0619
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0127 0.3768
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0351 0.0351
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0115 0.168
Schistosoma mansoni ferritin light chain 0.0018 0.0008 0.0008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0118 0.0608 0.2359
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0227 0.3343
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0008 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0027 0.0027
Brugia malayi Eye-specific diacylglycerol kinase 0.0017 0.0002 0.0017
Leishmania major diacylglycerol kinase-like protein 0.0017 0.0002 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Brugia malayi photoreceptor-specific nuclear receptor 0.0055 0.0227 0.3343
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0017 0.0002 0.0061
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0127 0.7921
Toxoplasma gondii diacylglycerol kinase, putative 0.0017 0.0002 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0059 0.4526
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0203
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0318 0.0317
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0027 0.0098
Brugia malayi hypothetical protein 0.0026 0.0054 0.0773
Entamoeba histolytica hypothetical protein 0.0023 0.0035 0.0128
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0027 0.0204
Loa Loa (eye worm) hypothetical protein 0.0055 0.0227 0.088
Loa Loa (eye worm) hypothetical protein 0.0054 0.0225 0.0871
Echinococcus granulosus geminin 0.0184 0.1005 0.1004
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0059 0.4526
Loa Loa (eye worm) hypothetical protein 0.0055 0.0227 0.088
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0027 0.0095
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0011 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0059 0.4526
Schistosoma mansoni nuclear receptor 0.0026 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0203
Onchocerca volvulus Bile acid receptor homolog 0.0055 0.0227 0.3719
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0336 0.1297
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0194 0.0192
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0055 0.0227 0.0226
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0127 0.7921
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0055 0.0227 0.088
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0336 0.4944
Brugia malayi CXXC zinc finger family protein 0.0118 0.0608 0.8961
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0206 0.0205
Onchocerca volvulus 0.0118 0.0608 1
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0206 0.0206
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0027 0.0505
Mycobacterium ulcerans hypothetical protein 0.0444 0.2572 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0027 0.0681
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0225 0.5629
Schistosoma mansoni ferritin light chain 0.0018 0.0008 0.0008
Loa Loa (eye worm) MBCTL1 0.0058 0.0248 0.0961
Loa Loa (eye worm) hypothetical protein 0.0073 0.0336 0.1301
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0004
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0336 0.1297
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0074 0.0073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0059 0.4526
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0336 1
Schistosoma mansoni diacylglycerol kinase theta 0.0017 0.0002 0.0002
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0336 0.1297
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0008 0.0023
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0027 0.0098
Leishmania major DNA polymerase eta, putative 0.0044 0.016 0.4757
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0027 0.0098
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0207 0.0801
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0209 0.0808
Schistosoma mansoni tar DNA-binding protein 0.0037 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0059 0.4526
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0127 0.0491
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0011 0.0035
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0678 0.2632
Brugia malayi nuclear receptor NHR-88 0.0055 0.0227 0.3343
Trypanosoma brucei unspecified product 0.0019 0.0011 0.0619
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0011 0.0035
Echinococcus multilocularis thyroid hormone receptor alpha 0.0055 0.0227 0.0226
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0055 0.0227 0.0227
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0035 0.0128
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0225 0.087
Trypanosoma cruzi diacylglycerol kinase, putative 0.0017 0.0002 0.0061
Schistosoma mansoni cpg binding protein 0.0118 0.0608 0.0608
Schistosoma mansoni tar DNA-binding protein 0.0037 0.0118 0.0118
Onchocerca volvulus 0.0051 0.0206 0.3362

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2 nM Agonist activity at human PPARdelta by FRET assay ChEMBL. 17157013
EC50 (functional) = 2 nM Agonist activity at human PPARdelta by FRET assay ChEMBL. 17157013
EC50 (functional) = 120 nM Agonist activity at human PPARalpha by FRET assay ChEMBL. 17157013
EC50 (functional) = 120 nM Agonist activity at human PPARalpha by FRET assay ChEMBL. 17157013
EC50 (functional) = 950 nM Agonist activity at PPARgamma in mouse 3T3-L1 cells by IRBA ChEMBL. 17157013
EC50 (functional) = 950 nM Agonist activity at PPARgamma in mouse 3T3-L1 cells by IRBA ChEMBL. 17157013

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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