Detailed information for compound 459338

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 532.579 | Formula: C29H34FN2NaO5
  • H donors: 2 H acceptors: 5 LogP: 4.43 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@@H](C[C@H](CC(=O)[O-])O)CCc1c(c2ccc(cc2)F)c(c(n1C(C)C)C(=O)N(C)C)c1ccccc1.[Na+]
  • InChi: 1S/C29H35FN2O5.Na/c1-18(2)32-24(15-14-22(33)16-23(34)17-25(35)36)26(20-10-12-21(30)13-11-20)27(19-8-6-5-7-9-19)28(32)29(37)31(3)4;/h5-13,18,22-23,33-34H,14-17H2,1-4H3,(H,35,36);/q;+1/p-1/t22-,23-;/m1./s1
  • InChiKey: UOHYEMZAMVUFMN-OHIDFYLOSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 3-hydroxy-3-methylglutaryl-CoA reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00021 3-hydroxy-3-methylglutaryl-CoA reductase [EC1.1.1.34], putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania mexicana 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania braziliensis 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase Get druggable targets OG5_127955 All targets in OG5_127955
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania infantum 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Candida albicans hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase Get druggable targets OG5_127955 All targets in OG5_127955
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma brucei gambiense 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein Get druggable targets OG5_127955 All targets in OG5_127955
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania donovani 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Candida albicans hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) Get druggable targets OG5_127955 All targets in OG5_127955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma congolense 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase Get druggable targets OG5_127955 All targets in OG5_127955
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0052 0.0055
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0048 0.0036
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0068 0.0414 0.0599
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Schistosoma mansoni alpha-glucosidase 0.0144 0.0964 0.0962
Brugia malayi Pre-SET motif family protein 0.0216 0.1486 0.2237
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0049 0.0052
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0074 0.0089
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0161 0.0148
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0341 0.1158
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0041 0.0093
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0341 0.0496
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0165 0.1119 0.1118
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0946 0.1416
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0052 0.0055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0011
Echinococcus multilocularis sterol regulatory element binding protein 0.0068 0.0414 0.0402
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.054 0.1863
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0062 0.006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0192 0.0629
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0192 0.0261
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0372 0.0543
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0021 0.0009
Mycobacterium ulcerans hypothetical protein 0.0023 0.0091 0.027
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0049 0.0043
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0025 0.0103 0.009
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0372 0.1268
Trichomonas vaginalis set domain proteins, putative 0.0245 0.17 0.2562
Trichomonas vaginalis helicase, putative 0.0014 0.0022 0.0011
Loa Loa (eye worm) DEAH box polypeptide 35 0.0166 0.1128 0.1685
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0052 0.0055
Brugia malayi hypothetical protein 0.002 0.0069 0.0082
Entamoeba histolytica deoxycytidyl transferase, putative 0.0058 0.0341 0.0494
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0599 0.0887
Schistosoma mansoni hypothetical protein 0.0297 0.2077 0.2075
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0058 0.0341 0.0496
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.019 0.0266
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0046
Brugia malayi Pre-SET motif family protein 0.0033 0.0161 0.0222
Echinococcus granulosus geminin 0.0365 0.2567 0.2557
Trichomonas vaginalis DNA polymerase eta, putative 0.0058 0.0341 0.0496
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0211 0.0298
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0226 0.032
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0609 0.6065
Trichomonas vaginalis dullard protein, putative 0.0025 0.0103 0.0134
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1062 0.3716
Brugia malayi mbt repeat family protein 0.0049 0.0276 0.0396
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0036 0.0185 0.0172
Echinococcus multilocularis GPCR, family 2 0.0018 0.0049 0.0036
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0091 0.027
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0325 0.0471
Trypanosoma brucei trypanothione reductase 0.0037 0.0192 0.027
Schistosoma mansoni lipoxygenase 0.0057 0.0335 0.0333
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.1119 0.1679
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.2087 0.3151
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Leishmania major DNA polymerase eta, putative 0.0109 0.0713 0.1062
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0068 0.0414 0.0413
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0176 0.0245
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0335 0.0322
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.092 0.659 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0041
Giardia lamblia DINP protein human, muc B family 0.0058 0.0341 0.0496
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0276 0.0387
Schistosoma mansoni alpha-glucosidase 0.0144 0.0964 0.0962
Loa Loa (eye worm) hypothetical protein 0.0165 0.1119 0.1672
Onchocerca volvulus 0.0062 0.0368 0.2164
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0325 0.0312
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0103 0.0134
Brugia malayi ImpB/MucB/SamB family protein 0.0109 0.0713 0.1062
Onchocerca volvulus 0.0245 0.17 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0126 0.0168
Leishmania major DNA polymerase kappa, putative 0.0018 0.0052 0.0055
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0048 0.0036
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0048 0.0036
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0599 0.0887
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0276 0.0274
Trypanosoma brucei unspecified product 0.004 0.0211 0.0298
Echinococcus granulosus dnaJ subfamily B 0.0877 0.6283 0.6278
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0015 0.5
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.1318 0.1307
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0414 0.0607
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0015 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0161 0.0159
Onchocerca volvulus 0.0097 0.0622 0.3657
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0483 0.0712
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.019 0.0266
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.1318 0.1307
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0009
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.092 0.659 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0226 0.032
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0091 0.027
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0013 0.0019 0.0006
Echinococcus multilocularis cpg binding protein 0.0065 0.0393 0.0381
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0016 0.0002
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.092 0.659 0.6586
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.1132 0.1121
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.054 0.1863
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0091 0.0116
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0326 0.0473
Schistosoma mansoni glutaminase 0.0306 0.2141 0.214
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.019 0.0266
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0015 0.0002
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.092 0.659 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0048 0.005
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0069 0.0082
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0945 0.3301
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0052 0.0055
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.2017 0.3044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0372 0.1268
Toxoplasma gondii thioredoxin reductase 0.0037 0.0192 0.027
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.1132 0.1121
Trypanosoma cruzi DNA polymerase eta, putative 0.0109 0.0713 0.1062
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0335 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0609 0.2108
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0013 0.0019 0.0006
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.2017 0.3045
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.092 0.659 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.0784 0.1169
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0946 0.1416
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0325 0.0312
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0276 0.0263
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0165 0.1119 0.1108
Brugia malayi hypothetical protein 0.0028 0.0126 0.0168
Brugia malayi Augmenter of liver regeneration 0.0035 0.0176 0.0245
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0257 0.0367
Brugia malayi Doublecortin family protein 0.002 0.0069 0.0082
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0052 0.0055
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0009
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0483 0.0712
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0165 0.1119 0.1679
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0048 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.1132 0.1699
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0058 0.0341 0.034
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0945 0.3301
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0126 0.0168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0161 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0052 0.0055
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0196 0.0183
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0945 1
Brugia malayi polk-prov protein 0.0018 0.0052 0.0055
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0372 0.1268
Brugia malayi CXXC zinc finger family protein 0.0062 0.0368 0.0536
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.2087 0.3151
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0192 0.027
Schistosoma mansoni SET domain protein 0.0017 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0213
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.092 0.659 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0325 0.0312
Trypanosoma brucei polo-like protein kinase 0.0093 0.0599 0.0887
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0802 0.5737 0.5731
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0052 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0483 0.0712
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.019 0.0266
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0043
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0161 0.0222
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.092 0.659 1
Leishmania major trypanothione reductase 0.0037 0.0192 0.027
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.2087 0.3151
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0058 0.0341 0.0487
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.092 0.659 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0161 0.0159
Schistosoma mansoni hypothetical protein 0.0018 0.0049 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0325 0.0323
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0341 0.0496
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0103 0.0134
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0091 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0211 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.0106
Giardia lamblia DNA damage repair protein 0.0018 0.0052 0.0055
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0021 0.0009
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0049 0.0052
Loa Loa (eye worm) hypothetical protein 0.0124 0.0819 0.1215
Loa Loa (eye worm) glutaminase 2 0.0306 0.2141 0.3227
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.1119 0.1679
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0176 0.0163
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.1486 0.223
Echinococcus multilocularis RUN 0.002 0.0069 0.0056
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0048 0.005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0041
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.054 0.5256
Echinococcus multilocularis geminin 0.0365 0.2567 0.2557
Trichomonas vaginalis glutaminase, putative 0.0306 0.2141 0.3233
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0076 0.0063
Schistosoma mansoni polycystin 1-related 0.002 0.0069 0.0067
Schistosoma mansoni kinase 0.0047 0.0265 0.0264
Schistosoma mansoni terminal deoxycytidyl transferase 0.0058 0.0341 0.034
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.054 0.1863
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0368 0.0528
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0069 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0048 0.0117
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0069 0.0056
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.1119 0.1679
Giardia lamblia Kinase, PLK 0.0093 0.0599 0.0887
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0176 0.0245
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0091 0.0116
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0126 0.0168
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Leishmania major DNA polymerase eta, putative 0.0069 0.0424 0.0621
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0176 0.0163
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0042 0.0041
Loa Loa (eye worm) glutathione reductase 0.0037 0.0192 0.0261
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0341 0.1158
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0058 0.0341 0.0496
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0135 0.0122
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0196 0.0183
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0091 0.027
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.092 0.659 1
Echinococcus multilocularis 0.0025 0.0103 0.009
Schistosoma mansoni hypothetical protein 0.0013 0.0013 0.0011
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0103 0.0102
Onchocerca volvulus 0.002 0.0069 0.0405
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0609 0.2108
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0091 0.027
Schistosoma mansoni loxhd1 0.002 0.0069 0.0067
Mycobacterium ulcerans hypothetical protein 0.0402 0.2833 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0091 0.027
Leishmania major hypothetical protein, conserved 0.0035 0.0176 0.0245
Brugia malayi hypothetical protein 0.002 0.0069 0.0082
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0069 0.0056
Plasmodium vivax glutathione reductase, putative 0.0037 0.0192 0.027
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0025 0.0103 0.0132
Echinococcus multilocularis Niemann Pick C1 protein 0.0068 0.0414 0.0402
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0049 0.0036
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0091 0.027
Loa Loa (eye worm) hypothetical protein 0.0068 0.0414 0.0599
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0946 0.1416
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Loa Loa (eye worm) doublecortin family protein 0.002 0.0069 0.0073
Plasmodium falciparum glutathione reductase 0.0037 0.0192 0.027
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0021 0.0007
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.0341 0.1158
Brugia malayi hypothetical protein 0.0018 0.0053 0.0058
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0009
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0048 0.0036
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0078 0.0095
Echinococcus multilocularis dna polymerase kappa 0.0058 0.0341 0.0329
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0025 0.0103 0.0134
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.092 0.659 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Mycobacterium ulcerans hypothetical protein 0.0157 0.1062 0.3716
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0011
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.054 0.1863
Echinococcus granulosus Protein patched homolog 1 0.0068 0.0414 0.0402
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.092 0.659 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0292 0.0422
Schistosoma mansoni hypothetical protein 0.0365 0.2567 0.2565
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Echinococcus granulosus CTD small phosphatase protein like 0.0025 0.0103 0.009
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0257 0.0367
Mycobacterium ulcerans hypothetical protein 0.0018 0.0052 0.0129
Brugia malayi ImpB/MucB/SamB family protein 0.0058 0.0341 0.0496
Loa Loa (eye worm) hypothetical protein 0.0056 0.0325 0.0462
Echinococcus multilocularis microtubule associated protein 2 0.139 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0016 0.0002
Schistosoma mansoni SET domain protein 0.0036 0.0185 0.0183
Schistosoma mansoni microtubule-associated protein tau 0.139 1 1
Trichomonas vaginalis dullard protein, putative 0.0025 0.0103 0.0134
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0103 0.0134
Trypanosoma cruzi DNA polymerase eta, putative 0.0069 0.0424 0.0621
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.019 0.0266
Schistosoma mansoni hypothetical protein 0.002 0.0069 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Trypanosoma brucei unspecified product 0.004 0.0211 0.0298
Echinococcus multilocularis protein dispatched 1 0.0068 0.0414 0.0402
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0326 0.0464
Loa Loa (eye worm) hypothetical protein 0.0049 0.0276 0.0387
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.019 0.0266
Trypanosoma brucei DNA polymerase eta, putative 0.0109 0.0713 0.1062
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0372 0.0371
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0021 0.0009
Loa Loa (eye worm) glutaminase 0.0306 0.2141 0.3227
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.092 0.659 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0016 0.0002
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0599 0.0886
Schistosoma mansoni hypothetical protein 0.0018 0.0049 0.0048
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.019 0.0266
Onchocerca volvulus 0.0023 0.0091 0.0536
Loa Loa (eye worm) hypothetical protein 0.0056 0.0326 0.0464
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0049 0.0036
Mycobacterium tuberculosis Probable reductase 0.0085 0.054 0.1863
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.054 0.0796
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.01 0.0128
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0326 0.0473
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.019 0.0266
Trypanosoma brucei glucosidase, putative 0.0037 0.019 0.0266
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0025 0.0103 0.0134
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0165 0.1119 0.1108
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0176 0.0245
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0041 0.0093
Loa Loa (eye worm) hypothetical protein 0.0085 0.054 0.079
Schistosoma mansoni rab6-interacting 0.002 0.0069 0.0067
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.1132 0.1691
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0609 0.2108
Echinococcus multilocularis dna polymerase eta 0.0109 0.0713 0.0701
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.1119 0.1679
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.019 0.0264
Trypanosoma brucei unspecified product 0.0058 0.0341 0.0496
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.2087 0.3151
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0011
Brugia malayi Thioredoxin reductase 0.0037 0.0192 0.027
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0276 0.0263
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0091 0.027
Brugia malayi Probable ATP-dependent helicase DHX35 0.0166 0.1128 0.1693
Onchocerca volvulus 0.002 0.0069 0.0405
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0226 0.032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0052 0.0055
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0091 0.0114
Schistosoma mansoni hypothetical protein 0.0365 0.2567 0.2565
Brugia malayi CHE-14 protein 0.0068 0.0414 0.0607
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0069 0.0082
Schistosoma mansoni hypothetical protein 0.0018 0.0049 0.0048
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0126 0.0168
Loa Loa (eye worm) RecQ helicase 0.0025 0.01 0.0119
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.092 0.659 1
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0036 0.0185 0.0172
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0126 0.0168
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0076 0.0063
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0165 0.1119 0.3919
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0025 0.0103 0.0134
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0599 0.0586
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0176 0.0245
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0091 0.0114
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.1132 0.1121
Schistosoma mansoni patched 1 0.0068 0.0414 0.0413
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0078 0.0483 0.0712
Echinococcus multilocularis 0.092 0.659 0.6586
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0276 0.0274
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0069 0.0056
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.092 0.659 0.659
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0372 0.036
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0176 0.0245
Loa Loa (eye worm) hypothetical protein 0.0025 0.0101 0.0121
Trichomonas vaginalis dullard protein, putative 0.0025 0.0103 0.0134
Toxoplasma gondii hypothetical protein 0.0048 0.027 0.0388
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0276 0.0263
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0372 0.1268
Leishmania major DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0103 0.0102
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0021 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.019 0.0266
Schistosoma mansoni hypothetical protein 0.0038 0.0198 0.0196
Schistosoma mansoni cpg binding protein 0.0065 0.0393 0.0392
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0009
Mycobacterium ulcerans glutaminase 0.0306 0.2141 0.7544
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0016 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0192 0.027
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0276 0.0274
Echinococcus granulosus bloom syndrome protein 0.0025 0.01 0.0087
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0021 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.019 0.0266
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0372 0.0543
Schistosoma mansoni hypothetical protein 0.0877 0.6283 0.6282
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.019 0.0266
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0052 0.0055
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0276 0.0263
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0599 0.0887
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0091 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0599 0.3521
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.019 0.0177
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0091 0.027
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0015 0.0002
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0176 0.0245
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0052 0.0055
Loa Loa (eye worm) MBCTL1 0.0056 0.0325 0.0462
Loa Loa (eye worm) hypothetical protein 0.0028 0.0126 0.0159
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.019 0.0177
Loa Loa (eye worm) hypothetical protein 0.0109 0.0713 0.1054
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0021 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0011
Echinococcus granulosus dna polymerase kappa 0.0058 0.0341 0.0329
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0021 0.0009
Echinococcus granulosus cpg binding protein 0.0065 0.0393 0.0381
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0599 0.0887
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0009
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0599 0.0879
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0176 0.0236
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0011
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0052 0.0055
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.01 0.0128
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0372 0.0371
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0049 0.0036
Schistosoma mansoni hypothetical protein 0.0025 0.0101 0.0099
Onchocerca volvulus 0.0049 0.0276 0.1622
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0058 0.0341 0.1158
Echinococcus granulosus sterol regulatory element binding protein 0.0068 0.0414 0.0402
Plasmodium falciparum thioredoxin reductase 0.0037 0.0192 0.027
Echinococcus granulosus GPCR family 2 0.0018 0.0049 0.0036
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.092 0.659 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0049 0.0036
Schistosoma mansoni DNA polymerase eta 0.0109 0.0713 0.0712
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0402 0.2833 1
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.2017 1
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0176 0.0245
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Onchocerca volvulus 0.0033 0.0161 0.0947
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.092 0.659 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0372 0.036
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0058 0.0341 0.0329
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0126 0.0168
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.019 0.0266
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0041 0.0093
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0276 0.1622
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0025 0.0103 0.0134
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0161 0.0148
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0091 0.0116
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0021 0.0009
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0021 0.0009
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0025 0.0103 0.009
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0226 0.032
Schistosoma mansoni alpha glucosidase 0.0037 0.019 0.0188
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0103 0.0134
Schistosoma mansoni lipoxygenase 0.002 0.0069 0.0067
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0052 0.0055
Echinococcus granulosus dna polymerase eta 0.0109 0.0713 0.0701
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.0106
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0048 0.0047
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.004 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Plasmodium vivax SET domain protein, putative 0.0033 0.0161 0.0222
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0052 0.005
Echinococcus multilocularis bloom syndrome protein 0.0025 0.01 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0599 0.0597
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0198 0.0278
Schistosoma mansoni rab6-interacting 0.002 0.0069 0.0067
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0176 0.0245
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.019 0.0257
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.2017 0.3044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0041 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.019 0.0266
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.019 0.0264
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0161 0.0148
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0069 0.0056
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0058 0.0341 0.0329
Loa Loa (eye worm) hypothetical protein 0.0038 0.0198 0.0269
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0048 0.0117
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.0106
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0015 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Brugia malayi glutaminase DH11.1 0.0306 0.2141 0.3233
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0052 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0103 0.0134
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0041
Schistosoma mansoni cpg binding protein 0.0065 0.0393 0.0392
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0052 0.0055
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0025 0.0103 0.0134
Leishmania major hypothetical protein, conserved 0.0025 0.0103 0.0134
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.0885 0.0884
Brugia malayi protein-S isoprenylcysteine O-methyltransferase, putative 0.092 0.659 1
Schistosoma mansoni hypothetical protein 0.0018 0.0049 0.0048
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.054 0.1863
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.019 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0211 0.0298
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0599 0.0586
Echinococcus multilocularis dnaJ subfamily B 0.0877 0.6283 0.6278
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0126 0.0168
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0103 0.0134
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0325 0.0312
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0076 0.0083
Echinococcus granulosus Niemann Pick C1 protein 0.0068 0.0414 0.0402
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0091 0.0114
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.01 0.0128
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0069 0.0056
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0103 0.0134
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0091 0.0116
Loa Loa (eye worm) hypothetical protein 0.0166 0.1128 0.1685
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Echinococcus multilocularis protein patched 0.0068 0.0414 0.0402
Leishmania major hypothetical protein, conserved 0.0028 0.0126 0.0168
Schistosoma mansoni cpg binding protein 0.0062 0.0368 0.0366
Echinococcus granulosus RUN 0.002 0.0069 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0091 0.0116
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Leishmania major DNA damage repair protein, putative 0.0018 0.0052 0.0055
Brugia malayi glutathione reductase 0.0037 0.0192 0.027
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0341 0.0496
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0052 0.0055
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0161 0.0159
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0069 0.0424 0.0621
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0041
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.054 0.0796
Brugia malayi mbt repeat family protein 0.0049 0.0276 0.0396

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.9 nM Inhibition of cholesterol synthesis in rat hepatocyte ChEMBL. 17574412
IC50 (binding) = 20 nM Inhibition of HMG-CoA reductase ChEMBL. 17574412
IC50 (binding) = 20 nM Inhibition of HMG-CoA reductase ChEMBL. 17574412
IC50 (functional) = 1580 nM Inhibition of cholesterol synthesis in rat myocyte ChEMBL. 17574412
Inhibition (functional) = -85 % Inhibition of acute cholesterol synthesis in mouse at 1 mg/kg ChEMBL. 17574412
Inhibition (functional) = -85 % Inhibition of acute cholesterol synthesis in mouse at 1 mg/kg ChEMBL. 17574412

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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