Detailed information for compound 459338

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 532.579 | Formula: C29H34FN2NaO5
  • H donors: 2 H acceptors: 5 LogP: 4.43 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@@H](C[C@H](CC(=O)[O-])O)CCc1c(c2ccc(cc2)F)c(c(n1C(C)C)C(=O)N(C)C)c1ccccc1.[Na+]
  • InChi: 1S/C29H35FN2O5.Na/c1-18(2)32-24(15-14-22(33)16-23(34)17-25(35)36)26(20-10-12-21(30)13-11-20)27(19-8-6-5-7-9-19)28(32)29(37)31(3)4;/h5-13,18,22-23,33-34H,14-17H2,1-4H3,(H,35,36);/q;+1/p-1/t22-,23-;/m1./s1
  • InChiKey: UOHYEMZAMVUFMN-OHIDFYLOSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 3-hydroxy-3-methylglutaryl-CoA reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Schistosoma japonicum ko:K00021 3-hydroxy-3-methylglutaryl-CoA reductase [EC1.1.1.34], putative Get druggable targets OG5_127955 All targets in OG5_127955
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase Get druggable targets OG5_127955 All targets in OG5_127955
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma congolense 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania infantum 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania braziliensis 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Candida albicans hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) Get druggable targets OG5_127955 All targets in OG5_127955
Candida albicans hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania donovani 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania mexicana 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma brucei gambiense 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase Get druggable targets OG5_127955 All targets in OG5_127955
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein Get druggable targets OG5_127955 All targets in OG5_127955
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0091 0.027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0041
Schistosoma mansoni terminal deoxycytidyl transferase 0.0058 0.0341 0.034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0041 0.0093
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.1119 0.1679
Brugia malayi hypothetical protein 0.002 0.0069 0.0082
Brugia malayi ImpB/MucB/SamB family protein 0.0058 0.0341 0.0496
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0341 0.1158
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.0885 0.0884
Schistosoma mansoni SET domain protein 0.0017 0.0044 0.0042
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0021 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.2087 0.3151
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.092 0.659 1
Schistosoma mansoni rab6-interacting 0.002 0.0069 0.0067
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.054 0.1863
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0011
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0372 0.0543
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0196 0.0183
Echinococcus multilocularis geminin 0.0365 0.2567 0.2557
Leishmania major DNA polymerase kappa, putative 0.0018 0.0052 0.0055
Loa Loa (eye worm) glutaminase 2 0.0306 0.2141 0.3227
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.054 0.1863
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.2017 0.3044
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0036 0.0185 0.0172
Echinococcus granulosus cpg binding protein 0.0065 0.0393 0.0381
Loa Loa (eye worm) hypothetical protein 0.0025 0.0101 0.0121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0011
Schistosoma mansoni hypothetical protein 0.002 0.0069 0.0067
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0076 0.0063
Schistosoma mansoni SET domain protein 0.0036 0.0185 0.0183
Plasmodium falciparum thioredoxin reductase 0.0037 0.0192 0.027
Brugia malayi hypothetical protein 0.0028 0.0126 0.0168
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0103 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.019 0.0266
Onchocerca volvulus 0.0097 0.0622 0.3657
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0041 0.0093
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0946 0.1416
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.1318 0.1307
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.0341 0.1158
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0048 0.0036
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.019 0.0177
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.1318 0.1307
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0372 0.1268
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0025 0.0103 0.0134
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0016 0.0002
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0021 0.0125
Echinococcus multilocularis sterol regulatory element binding protein 0.0068 0.0414 0.0402
Loa Loa (eye worm) RecQ helicase 0.0025 0.01 0.0119
Giardia lamblia DINP protein human, muc B family 0.0058 0.0341 0.0496
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0198 0.0278
Loa Loa (eye worm) hypothetical protein 0.0109 0.0713 0.1054
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.092 0.659 1
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.092 0.659 1
Leishmania major DNA polymerase eta, putative 0.0069 0.0424 0.0621
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0021 0.0009
Echinococcus multilocularis 0.0025 0.0103 0.009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.0106
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0372 0.1268
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0176 0.0245
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0058 0.0341 0.1158
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0276 0.0274
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0021 0.0009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0049 0.0036
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0049 0.0052
Giardia lamblia Kinase, PLK 0.0093 0.0599 0.0887
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0049 0.0052
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0069 0.0056
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0052 0.0055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.1119 0.1679
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0176 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0211 0.0298
Trypanosoma brucei DNA polymerase eta, putative 0.0109 0.0713 0.1062
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.01 0.0128
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.054 0.0796
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0326 0.0464
Echinococcus multilocularis bloom syndrome protein 0.0025 0.01 0.0087
Loa Loa (eye worm) hypothetical protein 0.0085 0.054 0.079
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0091 0.0116
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0052 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0052 0.0055
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.092 0.659 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0048 1
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0076 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0211 0.0298
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0226 0.032
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0052 0.0055
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.1132 0.1121
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0073
Schistosoma mansoni cpg binding protein 0.0065 0.0393 0.0392
Schistosoma mansoni hypothetical protein 0.0365 0.2567 0.2565
Trypanosoma cruzi DNA polymerase eta, putative 0.0109 0.0713 0.1062
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.019 0.0266
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0599 0.0887
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0946 0.1416
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0091 0.027
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Loa Loa (eye worm) hypothetical protein 0.0038 0.0198 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.2017 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0609 0.2108
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0161 0.0148
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0165 0.1119 0.1108
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0372 0.1268
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0599 0.0586
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0103 0.0134
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0483 0.0712
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0325 0.0312
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0091 0.0116
Leishmania major DNA damage repair protein, putative 0.0018 0.0052 0.0055
Schistosoma mansoni hypothetical protein 0.0013 0.0013 0.0011
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.1119 0.1679
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0126 0.0168
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0226 0.032
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0103 0.0134
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.1132 0.1699
Schistosoma mansoni hypothetical protein 0.0018 0.0049 0.0048
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.019 0.0266
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0599 0.0887
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.0784 0.1169
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0058 0.0341 0.034
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0048 0.005
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0341 0.1158
Trypanosoma brucei unspecified product 0.004 0.0211 0.0298
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0091 0.027
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0091 0.0116
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0025 0.0103 0.0134
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0165 0.1119 0.1679
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0058 0.0341 0.0329
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0335 0.0322
Echinococcus granulosus dna polymerase kappa 0.0058 0.0341 0.0329
Toxoplasma gondii thioredoxin reductase 0.0037 0.0192 0.027
Trypanosoma cruzi DNA polymerase eta, putative 0.0069 0.0424 0.0621
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Schistosoma mansoni alpha glucosidase 0.0037 0.019 0.0188
Echinococcus multilocularis microtubule associated protein 2 0.139 1 1
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0165 0.1119 0.3919
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0276 0.0263
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0049 0.0036
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.019 0.0266
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0048 0.0117
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0161 0.0148
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0103 0.0102
Schistosoma mansoni polycystin 1-related 0.002 0.0069 0.0067
Loa Loa (eye worm) hypothetical protein 0.0049 0.0276 0.0387
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.054 0.1863
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0325 0.0312
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.019 0.0257
Brugia malayi glutathione reductase 0.0037 0.0192 0.027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0091 0.0114
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.092 0.659 1
Echinococcus multilocularis RUN 0.002 0.0069 0.0056
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.019 0.0264
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.01 0.0128
Echinococcus granulosus CTD small phosphatase protein like 0.0025 0.0103 0.009
Echinococcus granulosus geminin 0.0365 0.2567 0.2557
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0009
Leishmania major trypanothione reductase 0.0037 0.0192 0.027
Schistosoma mansoni hypothetical protein 0.0025 0.0101 0.0099
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0341 0.0496
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.092 0.659 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0015 0.5
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0103 0.0134
Brugia malayi protein-S isoprenylcysteine O-methyltransferase, putative 0.092 0.659 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Echinococcus granulosus bloom syndrome protein 0.0025 0.01 0.0087
Mycobacterium ulcerans glutaminase 0.0306 0.2141 0.7544
Schistosoma mansoni loxhd1 0.002 0.0069 0.0067
Schistosoma mansoni rab6-interacting 0.002 0.0069 0.0067
Trypanosoma brucei glucosidase, putative 0.0037 0.019 0.0266
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0015 0.0002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0372 0.036
Schistosoma mansoni hypothetical protein 0.0018 0.0049 0.0048
Schistosoma mansoni hypothetical protein 0.0877 0.6283 0.6282
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0091 0.0116
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0257 0.0367
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0609 0.6065
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0052 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0599 0.0886
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0325 0.0312
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.092 0.659 1
Giardia lamblia DNA damage repair protein 0.0018 0.0052 0.0055
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0052 0.0055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.1132 0.1691
Loa Loa (eye worm) doublecortin family protein 0.002 0.0069 0.0073
Brugia malayi CXXC zinc finger family protein 0.0062 0.0368 0.0536
Brugia malayi Pre-SET motif family protein 0.0216 0.1486 0.2237
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0372 0.0371
Brugia malayi glutaminase DH11.1 0.0306 0.2141 0.3233
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0076 0.0063
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0483 0.0712
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0016 0.0002
Loa Loa (eye worm) glutaminase 0.0306 0.2141 0.3227
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0276 0.0263
Echinococcus granulosus Protein patched homolog 1 0.0068 0.0414 0.0402
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0048 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0211 0.0298
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.019 0.0266
Echinococcus granulosus Niemann Pick C1 protein 0.0068 0.0414 0.0402
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.092 0.659 0.659
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0276 0.0263
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0192 0.027
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.1119 0.1679
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0326 0.0473
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0011
Echinococcus multilocularis cpg binding protein 0.0065 0.0393 0.0381
Trypanosoma brucei polo-like protein kinase 0.0093 0.0599 0.0887
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0015 0.0014
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.092 0.659 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0091 0.0116
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0325 0.0312
Brugia malayi polk-prov protein 0.0018 0.0052 0.0055
Trichomonas vaginalis set domain proteins, putative 0.0245 0.17 0.2562
Trichomonas vaginalis helicase, putative 0.0014 0.0022 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0041 0.0093
Schistosoma mansoni hypothetical protein 0.0365 0.2567 0.2565
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0946 0.1416
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0048 0.0036
Schistosoma mansoni glutaminase 0.0306 0.2141 0.214
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0103 0.0134
Schistosoma mansoni hypothetical protein 0.0018 0.0049 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Leishmania major DNA polymerase eta, putative 0.0109 0.0713 0.1062
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0021 0.0009
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0176 0.0245
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.054 0.1863
Brugia malayi hypothetical protein 0.0018 0.0053 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.019 0.0266
Loa Loa (eye worm) hypothetical protein 0.002 0.0069 0.0073
Onchocerca volvulus 0.0033 0.0161 0.0947
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0599 0.3521
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.019 0.0266
Echinococcus granulosus dna polymerase eta 0.0109 0.0713 0.0701
Schistosoma mansoni hypothetical protein 0.0018 0.0049 0.0048
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0091 0.0114
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0069 0.0082
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0058 0.0341 0.0496
Schistosoma mansoni patched 1 0.0068 0.0414 0.0413
Schistosoma mansoni lipoxygenase 0.0057 0.0335 0.0333
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0483 0.0712
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.092 0.659 0.6586
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0011
Trypanosoma brucei unspecified product 0.0058 0.0341 0.0496
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0126 0.0168
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0058 0.0341 0.0329
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.1132 0.1121
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0103 0.0134
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0609 0.2108
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0078 0.0095
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0161 0.0159
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0802 0.5737 0.5731
Trichomonas vaginalis dullard protein, putative 0.0025 0.0103 0.0134
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0372 0.0543
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0091 0.027
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.092 0.659 1
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0341 0.0496
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0052 0.0055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0022 0.0011
Trichomonas vaginalis dullard protein, putative 0.0025 0.0103 0.0134
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0062 0.006
Onchocerca volvulus 0.002 0.0069 0.0405
Loa Loa (eye worm) hypothetical protein 0.0124 0.0819 0.1215
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Brugia malayi mbt repeat family protein 0.0049 0.0276 0.0396
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.2087 0.3151
Loa Loa (eye worm) DEAH box polypeptide 35 0.0166 0.1128 0.1685
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0011
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0025 0.0103 0.0134
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0161 0.0222
Onchocerca volvulus 0.0023 0.0091 0.0536
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0069 0.0056
Leishmania major hypothetical protein, conserved 0.0028 0.0126 0.0168
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0048 0.005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0372 0.1268
Plasmodium falciparum glutathione reductase 0.0037 0.0192 0.027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1062 0.3716
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0025 0.0103 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0052 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Mycobacterium tuberculosis Probable reductase 0.0085 0.054 0.1863
Echinococcus multilocularis GPCR, family 2 0.0018 0.0049 0.0036
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0368 0.0528
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.054 0.1863
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0041 0.0093
Echinococcus granulosus RUN 0.002 0.0069 0.0056
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0078 0.0483 0.0712
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0058 0.0341 0.0496
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0025 0.0103 0.009
Schistosoma mansoni cpg binding protein 0.0065 0.0393 0.0392
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0074 0.0089
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0068 0.0414 0.0413
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.2087 0.3151
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0052 0.0055
Schistosoma mansoni hypothetical protein 0.0297 0.2077 0.2075
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0341 0.0496
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0292 0.0422
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0176 0.0163
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0091 0.027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0041
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0069 0.0056
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.2017 0.3044
Onchocerca volvulus 0.0049 0.0276 0.1622
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0213
Loa Loa (eye worm) hypothetical protein 0.0056 0.0325 0.0462
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0049 0.0036
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.092 0.659 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0196 0.0183
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0192 0.027
Loa Loa (eye worm) hypothetical protein 0.0166 0.1128 0.1685
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0058 0.0341 0.0487
Echinococcus granulosus GPCR family 2 0.0018 0.0049 0.0036
Mycobacterium ulcerans hypothetical protein 0.0402 0.2833 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Echinococcus multilocularis dnaJ subfamily B 0.0877 0.6283 0.6278
Leishmania major hypothetical protein, conserved 0.0025 0.0103 0.0134
Schistosoma mansoni alpha-glucosidase 0.0144 0.0964 0.0962
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0015 0.0002
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0025 0.0103 0.0132
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0103 0.0134
Echinococcus multilocularis protein patched 0.0068 0.0414 0.0402
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0192 0.0261
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.019 0.0266
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0176 0.0163
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0276 0.1622
Plasmodium vivax SET domain protein, putative 0.0033 0.0161 0.0222
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0176 0.0245
Schistosoma mansoni kinase 0.0047 0.0265 0.0264
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0069 0.0056
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0945 0.3301
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0091 0.027
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0021 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0257 0.0367
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0126 0.0168
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0372 0.0371
Mycobacterium ulcerans hypothetical protein 0.0023 0.0091 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0599 0.0879
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0068 0.0414 0.0599
Leishmania major hypothetical protein, conserved 0.0035 0.0176 0.0245
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0052 0.005
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0052 0.0055
Schistosoma mansoni DNA polymerase eta 0.0109 0.0713 0.0712
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0165 0.1119 0.1108
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.092 0.659 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0048 0.0036
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0161 0.0148
Brugia malayi mbt repeat family protein 0.0049 0.0276 0.0396
Onchocerca volvulus 0.0062 0.0368 0.2164
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0165 0.1119 0.1118
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0009
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.054 0.0796
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0013 0.0019 0.0006
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.2017 0.3045
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.019 0.0177
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0326 0.0473
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0052 0.0055
Loa Loa (eye worm) hypothetical protein 0.0056 0.0326 0.0464
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0126 0.0168
Trichomonas vaginalis glutaminase, putative 0.0306 0.2141 0.3233
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0276 0.0387
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0016 0.0002
Mycobacterium ulcerans hypothetical protein 0.0157 0.1062 0.3716
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0126 0.0168
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.092 0.659 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0048 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Trichomonas vaginalis dullard protein, putative 0.0025 0.0103 0.0134
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0126 0.0168
Echinococcus multilocularis protein dispatched 1 0.0068 0.0414 0.0402
Loa Loa (eye worm) MBCTL1 0.0056 0.0325 0.0462
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.019 0.0266
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0945 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Plasmodium vivax glutathione reductase, putative 0.0037 0.0192 0.027
Mycobacterium ulcerans hypothetical protein 0.0018 0.0052 0.0129
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0025 0.0103 0.0134
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0091 0.027
Schistosoma mansoni hypothetical protein 0.0038 0.0198 0.0196
Trichomonas vaginalis DNA polymerase eta, putative 0.0058 0.0341 0.0496
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0069 0.0082
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0052 0.0055
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0046
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0013 0.0019 0.0006
Brugia malayi Pre-SET motif family protein 0.0033 0.0161 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.019 0.0266
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0325 0.0471
Toxoplasma gondii hypothetical protein 0.0048 0.027 0.0388
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.1486 0.223
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.019 0.0266
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0036 0.0185 0.0172
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.019 0.0266
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0176 0.0245
Onchocerca volvulus 0.0245 0.17 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0069 0.0056
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0176 0.0245
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.019 0.0264
Brugia malayi ImpB/MucB/SamB family protein 0.0109 0.0713 0.1062
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0021 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0091 0.027
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.2087 0.3151
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0599 0.0887
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0042 0.0041
Echinococcus multilocularis 0.092 0.659 0.6586
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0161 0.0159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0103 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0176 0.0245
Echinococcus granulosus sterol regulatory element binding protein 0.0068 0.0414 0.0402
Brugia malayi Augmenter of liver regeneration 0.0035 0.0176 0.0245
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.1132 0.1121
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0402 0.2833 1
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0276 0.0274
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0016 0.0002
Echinococcus granulosus dnaJ subfamily B 0.0877 0.6283 0.6278
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0176 0.0245
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0015 0.5
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.019 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0052 0.0055
Trypanosoma brucei trypanothione reductase 0.0037 0.0192 0.027
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.054 0.5256
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0325 0.0323
Schistosoma mansoni microtubule-associated protein tau 0.139 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0052 0.0055
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0945 0.3301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0161 0.0159
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0048 0.0117
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0049 0.0036
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0276 0.0263
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0192 0.0629
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0041
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0009
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0372 0.036
Echinococcus multilocularis dna polymerase eta 0.0109 0.0713 0.0701
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.092 0.659 1
Schistosoma mansoni alpha-glucosidase 0.0144 0.0964 0.0962
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Loa Loa (eye worm) hypothetical protein 0.0028 0.0126 0.0159
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0599 0.0887
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.0106
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.0106
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0021 0.0009
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0335 0.0322
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.092 0.659 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0011
Brugia malayi Probable ATP-dependent helicase DHX35 0.0166 0.1128 0.1693
Leishmania major DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0609 0.2108
Brugia malayi CHE-14 protein 0.0068 0.0414 0.0607
Loa Loa (eye worm) hypothetical protein 0.0068 0.0414 0.0599
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.01 0.0128
Loa Loa (eye worm) glutathione reductase 0.0037 0.0192 0.0261
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0091 0.0114
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.019 0.0266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.2017 0.3045
Echinococcus multilocularis Niemann Pick C1 protein 0.0068 0.0414 0.0402
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0091 0.0116
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0025 0.0103 0.009
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0126 0.0168
Entamoeba histolytica deoxycytidyl transferase, putative 0.0058 0.0341 0.0494
Brugia malayi hypothetical protein 0.002 0.0069 0.0082
Echinococcus multilocularis dna polymerase kappa 0.0058 0.0341 0.0329
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0226 0.032
Trypanosoma brucei unspecified product 0.004 0.0211 0.0298
Loa Loa (eye worm) hypothetical protein 0.0165 0.1119 0.1672
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0052 0.0055
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0043
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0069 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0161 0.0159
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0021 0.0007
Brugia malayi Doublecortin family protein 0.002 0.0069 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0414 0.0607
Schistosoma mansoni lipoxygenase 0.002 0.0069 0.0067
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0041
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0135 0.0122
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0599 0.0887
Onchocerca volvulus 0.002 0.0069 0.0405
Brugia malayi Thioredoxin reductase 0.0037 0.0192 0.027
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0009
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0226 0.032
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0049 0.0043
Schistosoma mansoni cpg binding protein 0.0062 0.0368 0.0366
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0069 0.0424 0.0621
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0176 0.0245
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0091 0.027
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0599 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0341 0.0496
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0599 0.0597
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0276 0.0274
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.004 0.0038

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.9 nM Inhibition of cholesterol synthesis in rat hepatocyte ChEMBL. 17574412
IC50 (binding) = 20 nM Inhibition of HMG-CoA reductase ChEMBL. 17574412
IC50 (binding) = 20 nM Inhibition of HMG-CoA reductase ChEMBL. 17574412
IC50 (functional) = 1580 nM Inhibition of cholesterol synthesis in rat myocyte ChEMBL. 17574412
Inhibition (functional) = -85 % Inhibition of acute cholesterol synthesis in mouse at 1 mg/kg ChEMBL. 17574412
Inhibition (functional) = -85 % Inhibition of acute cholesterol synthesis in mouse at 1 mg/kg ChEMBL. 17574412

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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