Detailed information for compound 48199

Basic information

Technical information
  • TDR Targets ID: 48199
  • Name: 3-(3,4-dimethoxyphenyl)piperidine
  • MW: 221.295 | Formula: C13H19NO2
  • H donors: 1 H acceptors: 0 LogP: 1.98 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C1CCCNC1
  • InChi: 1S/C13H19NO2/c1-15-12-6-5-10(8-13(12)16-2)11-4-3-7-14-9-11/h5-6,8,11,14H,3-4,7,9H2,1-2H3
  • InChiKey: GFRXXGINNMABOS-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cytidine deaminase, putative 0.0057 0.0375 0.036
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0093 0.0283
Onchocerca volvulus 0.0098 0.0775 0.1718
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0123 0.0136
Onchocerca volvulus 0.0069 0.0496 0.1073
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0529 0.0514
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0251 0.0278
Trichomonas vaginalis set domain proteins, putative 0.0463 0.4364 0.4355
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0162 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0139 0.0124
Brugia malayi steroid hormone receptor 0.0036 0.0166 0.0184
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0161 0.1394 0.138
Trypanosoma brucei thymidylate kinase, putative 0.0298 0.2743 0.2732
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.2736 0.3029
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0166 0.0184
Schistosoma mansoni thymidylate kinase 0.0298 0.2743 0.3349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0251 0.0236
Entamoeba histolytica Thymidylate kinase, putative 0.0298 0.2743 0.2732
Plasmodium vivax importin-beta 2, putative 0.0028 0.0088 0.0265
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0076 0.0566 0.0551
Echinococcus multilocularis tar DNA binding protein 0.0129 0.1084 0.12
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0075 0.0553 0.0676
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0376 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0162 0.0146
Onchocerca volvulus 0.0463 0.4364 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0162 0.0146
Loa Loa (eye worm) intermediate filament protein 0.008 0.0603 0.0668
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0033 0.0037
Echinococcus granulosus flap endonuclease 1 0.0025 0.0061 0.0068
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0093 0.0283
Brugia malayi ecdysteroid receptor 0.0036 0.0166 0.0184
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0376 0.0361
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0846 0.0937
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0562 0.2003
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1422 0.1409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0073 0.0057
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0166 0.0311
Echinococcus multilocularis musashi 0.008 0.0603 0.0668
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0529 0.0514
Echinococcus multilocularis lamin 0.008 0.0603 0.0668
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0061 0.0046
Trichomonas vaginalis glycogen phosphorylase, putative 0.0108 0.0872 0.0858
Echinococcus granulosus transcription factor btf3 0.0035 0.0157 0.0174
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0075 0.0553 0.0613
Trypanosoma cruzi thymidylate kinase, putative 0.0298 0.2743 0.2732
Trichomonas vaginalis cytidine deaminase, putative 0.0057 0.0375 0.036
Brugia malayi hypothetical protein 0.045 0.4232 0.4685
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.2265 0.2508
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0123 0.0107
Leishmania major cytidine deaminase-like protein 0.0057 0.0375 0.036
Trypanosoma brucei unspecified product 0.0027 0.008 0.0065
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0251 0.0278
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0166 0.0203
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0529 0.0514
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0123 0.0136
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0251 0.0236
Brugia malayi RNase H family protein 0.0022 0.0031 0.0034
Onchocerca volvulus 0.0057 0.0375 0.0794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0162 0.0146
Onchocerca volvulus 0.0191 0.1694 0.3839
Schistosoma mansoni lozenge 0.0056 0.0368 0.045
Echinococcus granulosus thymidylate synthase 0.0161 0.1394 0.1543
Schistosoma mansoni flap endonuclease-1 0.0023 0.0038 0.0046
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0529 0.0514
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0166 0.0184
Schistosoma mansoni hypothetical protein 0.0298 0.2743 0.3349
Brugia malayi Flap endonuclease-1 0.0025 0.0061 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0166 0.0184
Trypanosoma brucei thymidine kinase 0.1037 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1509 0.1496
Schistosoma mansoni survival motor neuron protein 0.0191 0.1694 0.2069
Schistosoma mansoni zinc finger protein 0.0019 0.0004 0.0005
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.2265 0.2508
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0166 0.0184
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0069 0.0496 0.0605
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0161 0.1394 0.4851
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0117 0.0964 0.095
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0161 0.1394 0.5053
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0057 0.0375 0.036
Schistosoma mansoni ap endonuclease 0.0057 0.0376 0.0459
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0166 0.0203
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0166 0.0184
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1422 0.1409
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.008 0.0065
Onchocerca volvulus 0.008 0.0603 0.1321
Echinococcus multilocularis thymidine kinase 0.0739 0.707 0.7828
Echinococcus multilocularis cytidine deaminase 0.0057 0.0375 0.0415
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0036 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1084 0.1323
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0251 0.0236
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0166 0.0184
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0166 0.0311
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0166 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0566 0.0551
Echinococcus multilocularis zinc finger protein 0.0019 0.0004 0.0005
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0846 0.1988
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0376 0.0416
Brugia malayi Intermediate filament tail domain containing protein 0.008 0.0603 0.0668
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0166 0.0184
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0093 0.0077
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0166 0.0203
Loa Loa (eye worm) thymidylate synthase 0.0161 0.1394 0.1543
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0846 0.0832
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0846 0.0832
Brugia malayi MH2 domain containing protein 0.0119 0.0984 0.109
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0166 0.0203
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0161 0.1394 0.5053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0162 0.0146
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0161 0.1394 0.5053
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.1177 0.1303
Loa Loa (eye worm) hypothetical protein 0.0079 0.0589 0.0652
Giardia lamblia Thymidine kinase 0.1037 1 1
Plasmodium vivax SET domain protein, putative 0.0058 0.0388 0.1364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0166 0.0184
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0123 0.0136
Echinococcus multilocularis geminin 0.0853 0.819 0.9068
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0093 0.0077
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0061 0.0046
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0376 0.1272
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0191 0.1694 0.1876
Brugia malayi RNA binding protein 0.0129 0.1084 0.12
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0075 0.0553 0.0676
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0031 0.0015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.1177 0.1303
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0166 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1177 0.1437
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0251 0.0236
Mycobacterium tuberculosis Hypothetical protein 0.0076 0.0566 0.1691
Loa Loa (eye worm) hypothetical protein 0.004 0.021 0.0233
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0166 0.0203
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0195 0.0216
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0061 0.0168
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.6364 0.777
Brugia malayi Bromodomain containing protein 0.0038 0.0186 0.0206
Trichomonas vaginalis thymidylate kinase, putative 0.0298 0.2743 0.2732
Brugia malayi hypothetical protein 0.0076 0.0566 0.0626
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0846 0.2323
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0195 0.0216
Leishmania major hypothetical protein, conserved 0.0076 0.0562 0.0547
Schistosoma mansoni glycogen phosphorylase 0.0108 0.0872 0.1065
Entamoeba histolytica glycogen phosphorylase, putative 0.0108 0.0872 0.0858
Brugia malayi M-phase phosphoprotein, mpp8 0.0098 0.0775 0.0859
Giardia lamblia Deoxynucleoside kinase 0.0393 0.3671 0.3661
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0157 0.0141
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0061 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.2265 0.2253
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0157 0.0141
Mycobacterium ulcerans cytidine deaminase 0.0057 0.0375 0.0418
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0061 0.0168
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0166 0.0184
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.2265 0.2253
Schistosoma mansoni hypothetical protein 0.0297 0.2736 0.334
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0376 0.0361
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0407 0.3812 0.422
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0529 0.0514
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0157 0.0518
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0057 0.0375 0.1317
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1422 0.1409
Echinococcus granulosus glycogen phosphorylase 0.0108 0.0872 0.0966
Schistosoma mansoni ap endonuclease 0.0057 0.0376 0.0459
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0529 0.0586
Brugia malayi nuclear hormone receptor 0.0036 0.0166 0.0184
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0163 0.0181
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0846 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0075 0.006
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0388 0.1364
Echinococcus multilocularis survival motor neuron protein 1 0.0938 0.9032 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1177 0.1303
Giardia lamblia Glycogen phosphorylase 0.0108 0.0872 0.0858
Echinococcus granulosus glycogen phosphorylase 0.0108 0.0872 0.0966
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1177 0.1437
Echinococcus granulosus ribonuclease H1 0.0022 0.0031 0.0034
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0376 0.0421
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0846 0.1033
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1084 0.1323
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0667 0.0815
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0123 0.0136
Schistosoma mansoni glycogen phosphorylase 0.0108 0.0872 0.1065
Leishmania major basic transcription factor 3a, putative 0.0035 0.0157 0.0141
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0036 0.0021
Trichomonas vaginalis thymidylate kinase, putative 0.0298 0.2743 0.2732
Entamoeba histolytica hypothetical protein 0.0071 0.0516 0.0502
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1422 0.1409
Brugia malayi hypothetical protein 0.0071 0.0516 0.0572
Entamoeba histolytica hypothetical protein 0.0071 0.0516 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0139 0.0124
Leishmania major hypothetical protein, conserved 0.0117 0.0964 0.095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0162 0.0146
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0562 0.2003
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0166 0.0184
Trichomonas vaginalis thymidine kinase, putative 0.1037 1 1
Echinococcus multilocularis glycogen phosphorylase 0.0108 0.0872 0.0966
Trichomonas vaginalis thymidine kinase, putative 0.1037 1 1
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0161 0.1394 0.1702
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0298 0.2743 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0562 0.0622
Leishmania major thymidylate kinase-like protein 0.0298 0.2743 0.2732
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0166 0.0203
Leishmania major importin beta-1 subunit, putative 0.0023 0.0036 0.0021
Loa Loa (eye worm) hypothetical protein 0.0306 0.2825 0.3128
Brugia malayi RNase H family protein 0.0022 0.0031 0.0034
Echinococcus granulosus tar DNA binding protein 0.0129 0.1084 0.12
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0093 0.0077
Entamoeba histolytica glycogen phosphorylase, putative 0.0108 0.0872 0.0858
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0166 0.0184
Loa Loa (eye worm) hypothetical protein 0.0037 0.0181 0.02
Toxoplasma gondii ribonuclease HI protein 0.0022 0.0031 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0166 0.0184
Echinococcus multilocularis ribonuclease H1 0.0022 0.0031 0.0034
Schistosoma mansoni hypothetical protein 0.0221 0.1982 0.2419
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0846 0.0832
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0667 0.0815
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1422 0.1409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1177 0.1437
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1509 0.1496
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0166 0.0203
Echinococcus multilocularis thyroid hormone receptor alpha 0.0167 0.1456 0.1612
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0088 0.0072
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0123 0.0107
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0376 0.0361
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0016 0.0017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0303 0.0336
Trypanosoma brucei ingi protein (ORF1) 0.0027 0.008 0.0065
Brugia malayi hypothetical protein 0.0076 0.0562 0.0622
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0166 0.0184
Entamoeba histolytica hypothetical protein 0.0071 0.0516 0.0502
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1084 0.1323
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0166 0.0203
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1177 0.1303
Entamoeba histolytica glycogenphosphorylase, putative 0.0047 0.0272 0.0256
Trichomonas vaginalis cytidine deaminase, putative 0.0057 0.0375 0.036
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0529 0.0514
Brugia malayi Inositol-1 0.0073 0.0529 0.0586
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0376 0.0361
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.1422 0.3211
Loa Loa (eye worm) RNA binding protein 0.0129 0.1084 0.12
Brugia malayi nuclear receptor NHR-88 0.0036 0.0166 0.0184
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0157 0.0174
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0139 0.0452
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0984 0.109
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0088 0.0097
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0394 0.0437
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0376 0.0361
Loa Loa (eye worm) inositol-1 0.0073 0.0529 0.0586
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0394 0.0437
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.1084 0.12
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0162 0.0146
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0161 0.1394 0.4302
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0365 0.3405 0.377
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0516 0.0572
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0157 0.0141
Chlamydia trachomatis glycogen phosphorylase 0.0108 0.0872 0.2941
Plasmodium falciparum flap endonuclease 1 0.0025 0.0061 0.0168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0388 0.0473
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0123 0.0136
Trypanosoma brucei thymidylate kinase, putative 0.0298 0.2743 0.2732
Schistosoma mansoni coup transcription factor 0.0036 0.0166 0.0203
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0376 0.0416
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1084 0.1323
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0036 0.0021
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0166 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0166 0.0184
Echinococcus granulosus importin subunit beta 1 0.0028 0.0088 0.0097
Trichomonas vaginalis ribonuclease H1, putative 0.0022 0.0031 0.0015
Giardia lamblia Ribonuclease H 0.0022 0.0031 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0075 0.006
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0093 0.0283
Schistosoma mansoni importin beta-1 0.0028 0.0088 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0166 0.0184
Brugia malayi RNA, U transporter 1 0.0079 0.0592 0.0656
Chlamydia trachomatis thymidylate kinase 0.0298 0.2743 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0166 0.0184
Loa Loa (eye worm) hypothetical protein 0.0098 0.0775 0.0859
Toxoplasma gondii thymidylate kinase 0.0298 0.2743 1
Schistosoma mansoni thymidine kinase 0.0739 0.707 0.8632
Plasmodium vivax thymidylate kinase, putative 0.0298 0.2743 1
Brugia malayi follicle stimulating hormone receptor 0.0457 0.4308 0.477
Schistosoma mansoni hypothetical protein 0.0191 0.1694 0.2069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0166 0.0184
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0098 0.0082
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.0529 0.1837
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0093 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0139 0.0124
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0251 0.0236
Onchocerca volvulus 0.0098 0.0775 0.1718
Brugia malayi PHD-finger family protein 0.0025 0.0056 0.0062
Mycobacterium ulcerans thymidylate synthase 0.0161 0.1394 0.454
Echinococcus multilocularis lamin dm0 0.008 0.0603 0.0668
Echinococcus granulosus Glycosyl transferase family 35 0.0108 0.0872 0.0966
Entamoeba histolytica hypothetical protein 0.0035 0.0157 0.0141
Trypanosoma cruzi thymidine kinase, putative 0.1037 1 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0016 0.0017
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0087 0.0667 0.0739
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0516 0.0572
Brugia malayi hypothetical protein 0.0098 0.0775 0.0859
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0123 0.0136
Brugia malayi hypothetical protein 0.0938 0.9032 1
Schistosoma mansoni phosphoglucomutase 0.0022 0.0031 0.0038
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0093 0.0283
Schistosoma mansoni hypothetical protein 0.002 0.0015 0.0018
Echinococcus granulosus thymidine kinase 0.0739 0.707 0.7828
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0184
Brugia malayi thymidylate synthase 0.0161 0.1394 0.1543
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0123 0.0392
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0846 0.0832
Onchocerca volvulus Putative thymidylate kinase 0.0298 0.2743 0.626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0251 0.0236
Schistosoma mansoni thymidylate kinase 0.0298 0.2743 0.3349
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0123 0.0392
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0251 0.0236
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0166 0.0184
Echinococcus multilocularis Glycosyl transferase, family 35 0.0108 0.0872 0.0966
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.2265 0.2253
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.6364 0.7046
Schistosoma mansoni bromodomain containing protein 0.0063 0.0429 0.0524
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0093 0.0077
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0376 0.1321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.005 0.0034
Leishmania major thymidine kinase, putative 0.1037 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0139 0.0124
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0117 0.0964 0.095
Onchocerca volvulus 0.045 0.4232 0.9696
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0251 0.0236
Schistosoma mansoni hypothetical protein 0.0209 0.1869 0.2282
Schistosoma mansoni phosphoglucomutase 0.0022 0.0031 0.0038
Echinococcus granulosus thymidine kinase 0.0739 0.707 0.7828
Schistosoma mansoni hypothetical protein 0.0853 0.819 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0149 0.0165
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0237 0.0262
Loa Loa (eye worm) hypothetical protein 0.005 0.0303 0.0336
Brugia malayi isocitrate dehydrogenase 0.0031 0.0123 0.0136
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0093 0.0077
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0027 0.008 0.0065
Giardia lamblia GTOR 0.0044 0.0251 0.0236
Brugia malayi beta-NAC-like protein 0.0035 0.0157 0.0174
Echinococcus granulosus solute carrier family 28 0.0365 0.3405 0.377
Schistosoma mansoni hypothetical protein 0.0034 0.0149 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0139 0.0124
Schistosoma mansoni hypothetical protein 0.0131 0.1104 0.1348
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0846 0.0832
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0166 0.0203
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0015 0.0016
Echinococcus granulosus geminin 0.0853 0.819 0.9068
Loa Loa (eye worm) glycogen phosphorylase 0.0108 0.0872 0.0966
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0161 0.1394 0.138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0139 0.0124
Trypanosoma cruzi thymidine kinase, putative 0.1037 1 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0529 0.1042
Echinococcus multilocularis transcription factor btf3 0.0035 0.0157 0.0174
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0061 0.0068
Onchocerca volvulus 0.0036 0.0166 0.0311
Trypanosoma brucei ingi protein (ORF1) 0.0027 0.008 0.0065
Echinococcus multilocularis Protein lozenge 0.0056 0.0368 0.0408
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0166 0.0184
Loa Loa (eye worm) TAR-binding protein 0.0129 0.1084 0.12
Loa Loa (eye worm) hypothetical protein 0.0042 0.0229 0.0253
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0251 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0166 0.0184
Echinococcus granulosus snurportin 1 0.0297 0.2736 0.3029
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0016 0.0017
Trypanosoma brucei ribonuclease H1 0.0022 0.0031 0.0015
Brugia malayi Importin beta-1 subunit 0.0028 0.0088 0.0097
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0376 0.0361
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0093 0.0283
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0016 0.0017
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0846 0.1033
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0061 0.0046
Toxoplasma gondii exonuclease III APE 0.0057 0.0376 0.1321
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0123 0.0107
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.015 0.0166
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0123 0.0107
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0166 0.0184
Loa Loa (eye worm) hypothetical protein 0.008 0.0603 0.0668
Schistosoma mansoni intermediate filament proteins 0.008 0.0603 0.0737
Echinococcus multilocularis thymidine kinase 0.0739 0.707 0.7828
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0457 0.4308 0.477
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0047 0.0272 0.0569
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.0454 0.1266
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0739 0.707 0.7828
Echinococcus multilocularis snurportin 1 0.0297 0.2736 0.3029
Schistosoma mansoni tar DNA-binding protein 0.0129 0.1084 0.1323
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0529 0.0514
Schistosoma mansoni glycogen phosphorylase 0.0047 0.0272 0.0332
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0516 0.063
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0123 0.0392
Echinococcus granulosus lamin 0.008 0.0603 0.0668
Giardia lamblia CDC8 0.0298 0.2743 0.2732
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0061 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0139 0.0124
Echinococcus multilocularis thymidylate synthase 0.0161 0.1394 0.1543
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0166 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0187 0.0172
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0272 0.0256
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0376 0.0361
Schistosoma mansoni thyroid hormone receptor 0.0167 0.1456 0.1777
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0093 0.0283
Brugia malayi RNase H family protein 0.0022 0.0031 0.0034
Schistosoma mansoni lamin 0.008 0.0603 0.0737
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0061 0.0046
Loa Loa (eye worm) hypothetical protein 0.0938 0.9032 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0184
Schistosoma mansoni lamin 0.008 0.0603 0.0737
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0166 0.0184
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0157 0.0518
Trypanosoma cruzi cytidine deaminase-like protein 0.0057 0.0375 0.036
Schistosoma mansoni thyroid hormone receptor 0.0167 0.1456 0.1777
Echinococcus multilocularis thymidylate kinase 0.0298 0.2743 0.3037
Echinococcus granulosus survival motor neuron protein 1 0.0938 0.9032 1
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.2265 0.2253
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0846 0.0937
Echinococcus multilocularis transfer RNA-Ile 0.0739 0.707 0.7828
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0388 0.0429
Plasmodium falciparum thymidylate kinase 0.0298 0.2743 1
Echinococcus multilocularis solute carrier family 28 0.0365 0.3405 0.377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0166 0.0184
Schistosoma mansoni phosphoglucomutase 0.0022 0.0031 0.0038
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0033 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1177 0.1303
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0036 0.0021
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0562 0.2003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0303 0.0336
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0107 0.0092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0184
Echinococcus granulosus histone lysine methyltransferase setb 0.0075 0.0553 0.0613
Brugia malayi intermediate filament protein 0.008 0.0603 0.0668
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0123 0.015
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0238 0.2156 0.2387
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0057 0.0375 0.0963
Loa Loa (eye worm) runx1 0.0056 0.0368 0.0408
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0123 0.0136
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0846 0.0937
Treponema pallidum thymidylate kinase (tmk) 0.0298 0.2743 1
Schistosoma mansoni hypothetical protein 0.0034 0.015 0.0183
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0562 0.2003
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0251 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0073 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0166 0.0184
Schistosoma mansoni transcription factor btf3 0.0035 0.0157 0.0192
Schistosoma mansoni hypothetical protein 0.0071 0.0516 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.005 0.0034
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0065 0.0454 0.0335
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0166 0.0184
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.015 0.0166
Trichomonas vaginalis thymidine kinase, putative 0.1037 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0021 0.0005
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0157 0.0141
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0846 0.0832
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0166 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0166 0.0184
Onchocerca volvulus 0.0057 0.0375 0.0794
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.008 0.0603 0.0668
Echinococcus granulosus thymidylate kinase 0.0298 0.2743 0.3037
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0529 0.1883
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.005 0.0034
Entamoeba histolytica glycogen phosphorylase, putative 0.0047 0.0272 0.0256
Trichomonas vaginalis glycogen phosphorylase, putative 0.0108 0.0872 0.0858
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0562 0.0547
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0529 0.0514
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0376 0.1321
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0123 0.0136
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0093 0.0077
Schistosoma mansoni ran 0.0021 0.0016 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.005 0.0034
Brugia malayi Pre-SET motif family protein 0.0058 0.0388 0.0429
Schistosoma mansoni ran 0.0021 0.0016 0.0019
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0161 0.1394 0.138
Echinococcus granulosus cytidine deaminase 0.0057 0.0375 0.0415
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0251 0.0278
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0093 0.0283
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.1084 0.12
Giardia lamblia Cytidine deaminase 0.0057 0.0375 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0157 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.005 0.0034
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0123 0.0392
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0157 0.0141
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0846 0.0832
Echinococcus granulosus lamin dm0 0.008 0.0603 0.0668
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.0207
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0251 0.0236
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0093 0.0077
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0093 0.0077
Brugia malayi Pre-SET motif family protein 0.0407 0.3812 0.422
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0162 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.005 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0166 0.0184
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0298 0.2743 1
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0031 0.0015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0165
Entamoeba histolytica hypothetical protein 0.0071 0.0516 0.0502
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0251 0.0278
Loa Loa (eye worm) hypothetical protein 0.0037 0.0181 0.02
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0166 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0075 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0562 0.0547
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0166 0.0184
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0365 0.3405 0.377
Brugia malayi 6-phosphofructokinase 0.0105 0.0846 0.0937
Trypanosoma brucei cytidine deaminase 0.0057 0.0375 0.036
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0846 0.276
Loa Loa (eye worm) hypothetical protein 0.0098 0.0775 0.0859
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0846 0.0832
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0123 0.0107
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1422 0.1409
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0376 0.1272
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0984 0.109
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0303 0.0336
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0166 0.0184
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0093 0.0077
Brugia malayi TAR-binding protein 0.0129 0.1084 0.12
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0088 0.0265
Loa Loa (eye worm) hypothetical protein 0.007 0.0501 0.0555
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0237 0.0262
Mycobacterium ulcerans thymidylate kinase 0.0298 0.2743 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0166 0.0184
Trypanosoma cruzi thymidylate kinase, putative 0.0298 0.2743 0.2732
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0376 0.0416
Loa Loa (eye worm) hypothetical protein 0.0075 0.0553 0.0613
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0365 0.3405 0.377
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.2265 0.2253
Loa Loa (eye worm) hypothetical protein 0.045 0.4232 0.4685
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0529 0.0586
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0376 0.0361
Schistosoma mansoni hypothetical protein 0.0853 0.819 1
Brugia malayi hypothetical protein 0.0049 0.0297 0.0329
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1422 0.1409
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0846 0.0937
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0157 0.0518
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0087 0.0667 0.0739
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0298 0.2743 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0061 0.0046
Loa Loa (eye worm) hypothetical protein 0.045 0.4232 0.4685
Echinococcus multilocularis glycogen phosphorylase 0.0108 0.0872 0.0966
Trypanosoma brucei RNA helicase, putative 0.0221 0.1982 0.1969
Plasmodium falciparum importin beta, putative 0.0028 0.0088 0.0265
Loa Loa (eye worm) thymidylate kinase 0.0298 0.2743 0.3037
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0562 0.0547
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.005 0.0034
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0157 0.0141
Schistosoma mansoni inositol monophosphatase 0.0073 0.0529 0.0646
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0166 0.0184
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0184
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0366 0.0406
Brugia malayi hypothetical protein 0.0118 0.097 0.1073
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0166 0.0184
Echinococcus granulosus intermediate filament protein 0.008 0.0603 0.0668
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0846 0.0832
Loa Loa (eye worm) hypothetical protein 0.0028 0.0088 0.0097
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0846 0.3004
Brugia malayi 6-phosphofructokinase 0.0105 0.0846 0.0937
Leishmania major ribonuclease H1, putative 0.0022 0.0031 0.0015
Brugia malayi Bromodomain containing protein 0.0074 0.0543 0.0601
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.2265 0.2253
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0166 0.0184
Brugia malayi phosphofructokinase 0.0105 0.0846 0.0937
Onchocerca volvulus Glycogen phosphorylase homolog 0.0108 0.0872 0.1942
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.1104 0.1222
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0376 0.0967
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0846 0.0937
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0088 0.0072
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0251 0.0306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0166 0.0184
Onchocerca volvulus 0.008 0.0603 0.1321
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0166 0.0184
Entamoeba histolytica hypothetical protein 0.0023 0.0036 0.0021
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0184
Brugia malayi thymidylate kinase 0.0298 0.2743 0.3037
Onchocerca volvulus 0.0161 0.1394 0.3145
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0166 0.0203
Brugia malayi carbohydrate phosphorylase 0.0108 0.0872 0.0966
Schistosoma mansoni inositol monophosphatase 0.0073 0.0529 0.0646
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0163 0.0181
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0033 0.0037
Echinococcus granulosus microtubule associated protein 2 0.0667 0.6364 0.7046
Brugia malayi cytidine deaminase, identical 0.0057 0.0375 0.0415
Loa Loa (eye worm) hypothetical protein 0.0039 0.0195 0.0216
Echinococcus granulosus zinc finger protein 0.0019 0.0004 0.0005
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.1104 0.1222
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1177 0.1303
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0166 0.0184

Activities

Activity type Activity value Assay description Source Reference
ED50 (binding) 0 uM kg-1 Dopamine receptor activation in limbic system of reserpinized rat ChEMBL. 6796690
ED50 (binding) 0 uM kg-1 Dopamine receptor activation in striatum of reserpinized rat ChEMBL. 6796690

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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