Detailed information for compound 500119

Basic information

Technical information
  • TDR Targets ID: 500119
  • Name: (3R,5R)-7-[2-(4-fluorophenyl)-5-[(4-methylphe nyl)methylcarbamoyl]-4-propan-2-ylpyrazol-3-y l]-3,5-dihydroxyheptanoic acid
  • MW: 511.585 | Formula: C28H34FN3O5
  • H donors: 4 H acceptors: 6 LogP: 3.86 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@@H](C[C@H](CC(=O)O)O)CCc1c(C(C)C)c(nn1c1ccc(cc1)F)C(=O)NCc1ccc(cc1)C
  • InChi: 1S/C28H34FN3O5/c1-17(2)26-24(13-12-22(33)14-23(34)15-25(35)36)32(21-10-8-20(29)9-11-21)31-27(26)28(37)30-16-19-6-4-18(3)5-7-19/h4-11,17,22-23,33-34H,12-16H2,1-3H3,(H,30,37)(H,35,36)/t22-,23-/m1/s1
  • InChiKey: LRVVTOGAGAXSRZ-DHIUTWEWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3R,5R)-7-[2-(4-fluorophenyl)-4-isopropyl-5-(p-tolylmethylcarbamoyl)pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid
  • (3R,5R)-7-[2-(4-fluorophenyl)-4-isopropyl-5-[oxo-(p-tolylmethylamino)methyl]-3-pyrazolyl]-3,5-dihydroxyheptanoic acid
  • (3R,5R)-7-[2-(4-fluorophenyl)-5-[(4-methylphenyl)methylcarbamoyl]-4-propan-2-yl-pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid
  • (3R,5R)-7-[2-(4-fluorophenyl)-4-isopropyl-5-[(4-methylbenzyl)carbamoyl]pyrazol-3-yl]-3,5-dihydroxy-enanthic acid
  • (3R,5R)-7-[2-(4-fluorophenyl)-4-isopropyl-5-[(4-methylphenyl)methylcarbamoyl]pyrazol-3-yl]-3,5-dihydroxy-heptanoic acid
  • (3R,5R)-7-[2-(4-fluorophenyl)-4-isopropyl-5-[[(4-methylphenyl)methylamino]-oxomethyl]-3-pyrazolyl]-3,5-dihydroxyheptanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus HMG-CoA reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00021 3-hydroxy-3-methylglutaryl-CoA reductase [EC1.1.1.34], putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania braziliensis 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase Get druggable targets OG5_127955 All targets in OG5_127955
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase Get druggable targets OG5_127955 All targets in OG5_127955
Candida albicans hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) Get druggable targets OG5_127955 All targets in OG5_127955
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase Get druggable targets OG5_127955 All targets in OG5_127955
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma brucei gambiense 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania mexicana 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127955 All targets in OG5_127955
Candida albicans hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania infantum 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma congolense 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Leishmania donovani 3-hydroxy-3-methylglutaryl-CoA reductase, putative Get druggable targets OG5_127955 All targets in OG5_127955
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase Get druggable targets OG5_127955 All targets in OG5_127955
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0407 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0304 0.0578
Echinococcus granulosus nuclear receptor nhr 48 0.0028 0.0313 0.0322
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0824 0.0802
Brugia malayi Sugar transporter family protein 0.0015 0.0037 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Plasmodium falciparum protein kinase 7 0.0296 0.573 0.655
Loa Loa (eye worm) beta-lactamase 0.0039 0.0522 0.0522
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.006 0.0955 0.1069
Plasmodium vivax SET domain protein, putative 0.0033 0.0407 0.0425
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1853 0.2115
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0165 0.3089 0.3554
Loa Loa (eye worm) histone methyltransferase 0.002 0.0153 0.0153
Brugia malayi hypothetical protein 0.0015 0.0037 0.0014
Trypanosoma cruzi hexose transporter 0.0032 0.0395 0.0522
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.1334 0.151
Mycobacterium tuberculosis Conserved protein 0.0039 0.0522 0.1032
Onchocerca volvulus 0.0023 0.0211 0.0199
Loa Loa (eye worm) runx1 0.0056 0.0873 0.0873
Schistosoma mansoni polycystin 1-related 0.0023 0.0211 0.0203
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0028 0.0313 0.0322
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0165 0.3089 0.3554
Schistosoma mansoni lipoxygenase 0.0065 0.1059 0.1191
Loa Loa (eye worm) hypothetical protein 0.0025 0.0255 0.0255
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0522 0.0565
Schistosoma mansoni cpg binding protein 0.0068 0.1113 0.1253
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0408 0.0427
Brugia malayi Augmenter of liver regeneration 0.0036 0.0474 0.0452
Plasmodium falciparum mitogen-activated protein kinase 2 0.0169 0.3174 0.361
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0105 0.0079
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0474 0.0769
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0955 0.1069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0258 0.0483
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0211 0.0387
Brugia malayi Nuclear hormone receptor family member nhr-49 0.006 0.0955 0.0934
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Schistosoma mansoni glucose transport protein 0.0104 0.1853 0.2115
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.3128 0.4505
Mycobacterium ulcerans beta-lactamase 0.0039 0.0522 0.1396
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.4736 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.006 0.0955 0.1069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0824 0.0917
Loa Loa (eye worm) hypothetical protein 0.0032 0.0382 0.0382
Schistosoma mansoni RAR-like nuclear receptor 0.006 0.0955 0.1069
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0037 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0304 0.0578
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0374 0.0392
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0068 0.1118 0.1118
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0098 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0037 0.0024
Onchocerca volvulus 0.0039 0.0522 0.0555
Echinococcus granulosus retinoic acid receptor rxr beta a 0.006 0.0955 0.1069
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0313 0.0322
Schistosoma mansoni rab6-interacting 0.0023 0.0211 0.0203
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Brugia malayi Cytochrome P450 family protein 0.0027 0.0285 0.0262
Schistosoma mansoni rab6-interacting 0.0023 0.0211 0.0203
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0474 0.0638
Leishmania major protein kinase, putative 0.0033 0.0407 0.054
Onchocerca volvulus 0.0446 0.8773 1
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0211 0.0203
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.3089 0.4448
Schistosoma mansoni hypothetical protein 0.0022 0.0182 0.0169
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313
Brugia malayi steroid hormone receptor 0.006 0.0955 0.0934
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0597 0.0641
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.1 0.1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0169 0.3174 0.361
Entamoeba histolytica hypothetical protein 0.0079 0.1334 1
Brugia malayi Steroid receptor seven-up type 2 0.006 0.0955 0.0934
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0522 0.1032
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0169 0.3174 0.5511
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0085 0.0056
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.0622 0.06
Toxoplasma gondii facilitative glucose transporter GT1 0.0104 0.1853 0.319
Loa Loa (eye worm) DR-78 0.0028 0.0313 0.0313
Leishmania major glucose transporter, lmgt1 0.0032 0.0395 0.0522
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0105 0.0079
Brugia malayi Bromodomain containing protein 0.0083 0.1418 0.1398
Schistosoma mansoni chromobox protein 0.007 0.1161 0.1309
Trypanosoma brucei ISWI complex protein 0.0016 0.0067 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0037 0.0024
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0294 0.03
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0037 0.0037
Brugia malayi nuclear hormone receptor 0.006 0.0955 0.0934
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0211 0.0254
Brugia malayi nuclear receptor RXR 0.0032 0.0382 0.0359
Schistosoma mansoni hypothetical protein 0.0023 0.0211 0.0203
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0374 0.0392
Onchocerca volvulus 0.0028 0.0313 0.0316
Echinococcus multilocularis Niemann Pick C1 protein 0.0068 0.1118 0.126
Echinococcus multilocularis chromobox protein 1 0.007 0.1161 0.1309
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.1334 0.151
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0522 0.1032
Trypanosoma brucei glucose transporter, putative 0.0032 0.0395 0.0522
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0407 0.0385
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0407 0.0431
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313
Brugia malayi major facilitator superfamily protein 0.0015 0.0037 0.0014
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0408 0.0427
Schistosoma mansoni patched 1 0.0068 0.1118 0.126
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0955 0.0934
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0211 0.1864
Mycobacterium tuberculosis Conserved protein 0.0039 0.0522 0.1032
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.2037 0.4179
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0113 0.2037 0.3514
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0522 0.1031
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0211 0.0502
Brugia malayi nuclear receptor NHR-67 0.0028 0.0313 0.029
Echinococcus granulosus chromobox protein 1 0.007 0.1161 0.1309
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0382 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0037 0.0024
Brugia malayi tailless protein 0.0028 0.0313 0.029
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0126 0.0208
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0522 0.1031
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.006 0.0955 0.0955
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0037 0.5
Echinococcus multilocularis tumor protein p63 0.0357 0.6976 0.8081
Leishmania major glucose transporter, lmgt3 0.0032 0.0395 0.0522
Brugia malayi MAP kinase sur-1 0.0113 0.2037 0.2019
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0395 0.0522
Schistosoma mansoni nuclear receptor nhr-48 0.0028 0.0313 0.0322
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0824 0.0917
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.006 0.0955 0.0955
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0167 0.3128 0.4505
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0622 0.0681
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0313 0.029
Brugia malayi hypothetical protein 0.0023 0.0211 0.0188
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0479 0.0644
Loa Loa (eye worm) hypothetical protein 0.0032 0.0382 0.0382
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0153 0.0135
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0639 0.0701
Brugia malayi hypothetical protein 0.0032 0.0382 0.0359
Echinococcus multilocularis mitogen activated protein kinase 0.0113 0.2037 0.233
Schistosoma mansoni glucose transport protein 0.0104 0.1853 0.2115
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0037 0.0014
Entamoeba histolytica hypothetical protein 0.0079 0.1334 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0505 0.0505
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0522 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.006 0.0955 0.1069
Loa Loa (eye worm) hypothetical protein 0.0052 0.0799 0.0799
Plasmodium falciparum protein kinase 6 0.0443 0.8728 1
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0211 0.0211
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0407 0.0431
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0313 0.0322
Brugia malayi nuclear receptor NHR-88 0.006 0.0955 0.0934
Schistosoma mansoni coup transcription factor 0.006 0.0955 0.1069
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0407 0.054
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0408 0.0427
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0382 0.0402
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0597 0.1187
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0407 0.0431
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0408 0.0427
Leishmania major cytochrome p450-like protein 0.0027 0.0285 0.0361
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.2436 0.2794
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Plasmodium vivax CDK-related protein kinase 6, putative 0.0443 0.8728 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0258 0.0483
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0522 0.0707
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0128
Brugia malayi hypothetical protein 0.0015 0.0037 0.0014
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0509 0.055
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0479 0.0508
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0068 0.1118 0.126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.006 0.0955 0.0955
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0113 0.2037 0.2916
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0479 0.0644
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0374 0.0392
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0622 0.0681
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.006 0.0955 0.1069
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0522 0.1396
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.3089 0.4448
Loa Loa (eye worm) hypothetical protein 0.0049 0.0725 0.0725
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0407 0.0431
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0955 0.1069
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.4224 0.4224
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0474 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.1853 0.3796
Loa Loa (eye worm) hypothetical protein 0.0033 0.0407 0.0407
Echinococcus granulosus General substrate transporter 0.009 0.1556 0.1769
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0105 0.0165
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.1311 0.267
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0395 0.0768
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0037 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0118 0.0118
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.1311 0.267
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.3128 0.4505
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.2037 0.4179
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0076 0.0046
Echinococcus multilocularis nuclear receptor nhr 48 0.0028 0.0313 0.0322
Echinococcus multilocularis sterol regulatory element binding protein 0.0068 0.1118 0.126
Loa Loa (eye worm) hepatopoietin HPO2 0.0036 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0408 0.0651
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0522 0.0707
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0165 0.3089 0.3554
Loa Loa (eye worm) hypothetical protein 0.006 0.0955 0.0955
Trichomonas vaginalis esterase, putative 0.0039 0.0522 0.1031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.006 0.0955 0.0955
Entamoeba histolytica protein kinase, putative 0.0033 0.0407 0.1745
Brugia malayi nuclear receptor NHR-88 0.0028 0.0313 0.029
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.2201 0.3802
Echinococcus multilocularis mitogen activated protein kinase 3 0.0113 0.2037 0.233
Giardia lamblia Kinase, CMGC MAPK 0.0113 0.2037 1
Loa Loa (eye worm) hypothetical protein 0.0446 0.8773 0.8773
Echinococcus multilocularis dnaJ subfamily B 0.0438 0.8623 1
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0037 0.0024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Echinococcus granulosus thyroid hormone receptor alpha 0.0028 0.0313 0.0322
Echinococcus granulosus chromobox protein 1 0.007 0.1161 0.1309
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0113 0.2037 0.2916
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0036 0.0474 0.051
Brugia malayi Doublecortin family protein 0.0023 0.0211 0.0188
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0028 0.0313 0.029
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0037 0.0024
Brugia malayi CXXC zinc finger family protein 0.0062 0.1 0.0979
Schistosoma mansoni nuclear receptor 0.0028 0.0313 0.0322
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0258 0.0483
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0374 0.1446
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0211 0.0203
Onchocerca volvulus 0.006 0.0955 0.1051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0772 0.0856
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.1853 0.2115
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0294 0.03
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.109 0.1227
Brugia malayi PHD-finger family protein 0.003 0.0345 0.0322
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.006 0.0955 0.1069
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1853 0.2115
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0211 0.0203
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0374 0.0724
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313
Echinococcus granulosus zinc finger protein 0.0024 0.0231 0.0226
Schistosoma mansoni lozenge 0.0056 0.0873 0.0974
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0258 0.0483
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0104 0.1853 0.2115
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0703 0.0775
Schistosoma mansoni thyroid hormone receptor 0.006 0.0955 0.1069
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Schistosoma mansoni loxhd1 0.0023 0.0211 0.0203
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0407 0.0431
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0522 0.1032
Loa Loa (eye worm) hypothetical protein 0.0031 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0474 0.0638
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0824 0.0917
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0564 0.1118
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0285 0.0361
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0395 0.0522
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0211 0.0502
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.006 0.0955 0.0955
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0028 0.0313 0.0313
Schistosoma mansoni chromobox protein 0.007 0.1161 0.1309
Mycobacterium tuberculosis Conserved protein 0.0039 0.0522 0.1032
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0285 0.0713
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.006 0.0955 0.1069
Brugia malayi conserved hypotetical protein 0.0028 0.0313 0.029
Toxoplasma gondii protein kinase, putative 0.0296 0.573 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.1853 0.2115
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0313 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.006 0.0955 0.0955
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0085 0.0056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0522 0.0522
Trypanosoma brucei glucose transporter, putative 0.0032 0.0395 0.0522
Echinococcus multilocularis thyroid hormone receptor alpha 0.006 0.0955 0.1069
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0036 0.0474 0.051
Trypanosoma brucei protein kinase, putative 0.0113 0.2037 0.2916
Leishmania major hypothetical protein, conserved 0.0039 0.0522 0.0707
Echinococcus granulosus ecdysone induced protein 78C 0.006 0.0955 0.1069
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0522 0.1031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.0955 0.0934
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0824 0.0917
Onchocerca volvulus 0.0023 0.0211 0.0199
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Onchocerca volvulus 0.0039 0.0522 0.0555
Brugia malayi Heterochromatin protein 1 0.007 0.1161 0.114
Echinococcus granulosus Niemann Pick C1 protein 0.0068 0.1118 0.126
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0258 0.0483
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0313 0.0322
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0479 0.0644
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0474 0.0638
Schistosoma mansoni cpg binding protein 0.0068 0.1113 0.1253
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.3089 0.4448
Schistosoma mansoni zinc finger protein 0.0016 0.0067 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-1 0.006 0.0955 0.0934
Onchocerca volvulus 0.0152 0.2822 0.3188
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0597 0.1187
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0474 0.0503
Onchocerca volvulus 0.0044 0.0639 0.0689
Echinococcus granulosus Protein patched homolog 1 0.0068 0.1118 0.126
Plasmodium vivax hexose transporter 0.0104 0.1853 0.2089
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313
Plasmodium falciparum hexose transporter 0.0104 0.1853 0.2089
Loa Loa (eye worm) hypothetical protein 0.0051 0.0772 0.0772
Toxoplasma gondii ABC1 family protein 0.0039 0.0522 0.0852
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0407 0.0793
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0955 0.1069
Echinococcus granulosus FTZ F1 alpha 0.006 0.0955 0.1069
Mycobacterium ulcerans hypothetical protein 0.0186 0.351 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0407 0.0431
Brugia malayi major facilitator superfamily protein 0.0015 0.0037 0.0014
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0113 0.2037 0.2916
Brugia malayi ecdysteroid receptor 0.006 0.0955 0.0934
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0746 0.1034
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.2037 0.233
Loa Loa (eye worm) nuclear hormone receptor 0.0028 0.0313 0.0313
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0285 0.0285
Mycobacterium leprae Probable lipase LipE 0.0039 0.0522 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Brugia malayi hypothetical protein 0.0028 0.0313 0.029
Schistosoma mansoni Tr4/Tr2 (homologue) 0.006 0.0955 0.1069
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0522 0.0522
Schistosoma mansoni zinc finger protein 0.0024 0.0231 0.0226
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0211 0.5
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0113 0.2037 0.2916
Mycobacterium ulcerans hypothetical protein 0.0039 0.0522 0.1396
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0313 0.0316
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0536 0.0572
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0522 0.1031
Brugia malayi ecdysone receptor 0.0028 0.0313 0.029
Brugia malayi Sugar transporter family protein 0.0104 0.1853 0.1834
Brugia malayi Sugar transporter family protein 0.0015 0.0037 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0211 0.0201
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0407 0.0431
Brugia malayi Cam kinase protein 1 0.0033 0.0407 0.0385
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Brugia malayi hypothetical protein 0.0446 0.8773 0.877
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0211 0.0203
Toxoplasma gondii hypothetical protein 0.0057 0.0894 0.1506
Echinococcus granulosus mitogen activated protein kinase 3 0.0113 0.2037 0.233
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0536 0.1061
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0211 0.0307
Onchocerca volvulus 0.0062 0.1 0.1102
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0285 0.0361
Schistosoma mansoni thyroid hormone receptor 0.006 0.0955 0.1069
Schistosoma mansoni glucose transport protein 0.0104 0.1853 0.2115
Leishmania major glucose transporter, lmgt2 0.0032 0.0395 0.0522
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0153 0.0135
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0407 0.0431
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0165 0.3089 0.3072
Brugia malayi beta-lactamase family protein 0.0039 0.0522 0.05
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0356 0.0371
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0395 0.0522
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.006 0.0955 0.1069
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.006 0.0955 0.1069
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0113 0.2037 0.2916
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0165 0.3089 0.8786
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0105 0.0079
Loa Loa (eye worm) hypothetical protein 0.0068 0.1118 0.1118
Loa Loa (eye worm) hypothetical protein 0.0031 0.0364 0.0364
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0285 0.0285
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.006 0.0955 0.1069
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0085 0.0056
Echinococcus granulosus dnaJ subfamily B 0.0438 0.8623 1
Schistosoma mansoni hypothetical protein 0.0079 0.1334 0.151
Loa Loa (eye worm) hypothetical protein 0.0446 0.8773 0.8773
Loa Loa (eye worm) hypothetical protein 0.0039 0.0522 0.0522
Onchocerca volvulus Protein ultraspiracle homolog 0.006 0.0955 0.1051
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0407 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-31 0.006 0.0955 0.0934
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0105 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0395 0.0768
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0211 0.0188
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0407 0.0407
Trypanosoma brucei glucose transporter, putative 0.0032 0.0395 0.0522
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0211 0.02
Brugia malayi beta-lactamase 0.0039 0.0522 0.05
Brugia malayi CHE-14 protein 0.0068 0.1118 0.1098
Trypanosoma brucei glucose transporter, putative 0.0032 0.0395 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.0955 0.0934
Onchocerca volvulus 0.0039 0.0522 0.0555
Trypanosoma brucei glucose transporter, putative 0.0032 0.0395 0.0522
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0408 0.0427
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0028 0.0313 0.0322
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.1853 0.2115
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0076 0.0046
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0211 0.0203
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1853 0.2115
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0408 0.0427
Brugia malayi Pre-SET motif family protein 0.0033 0.0407 0.0384
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0211 0.0254
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0258 0.0483
Loa Loa (eye worm) hypothetical protein 0.006 0.0955 0.0955
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0028 0.0313 0.0322
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0374 0.1684
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0085 0.0085
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0028 0.0313 0.0322
Loa Loa (eye worm) hypothetical protein 0.0031 0.0374 0.0374
Schistosoma mansoni protein kinase 0.0033 0.0407 0.0431
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0824 0.0917
Loa Loa (eye worm) hypothetical protein 0.0039 0.0522 0.0522
Brugia malayi hypothetical protein 0.0015 0.0037 0.0014
Loa Loa (eye worm) hypothetical protein 0.006 0.0955 0.0955
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Echinococcus multilocularis ecdysone induced protein 78C 0.006 0.0955 0.1069
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0522 0.0707
Echinococcus multilocularis RUN 0.0023 0.0211 0.0203
Schistosoma mansoni retinoic acid receptor RXR 0.006 0.0955 0.1069
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0076 0.0046
Brugia malayi hypothetical protein 0.0079 0.1334 0.1313
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0824 0.0917
Entamoeba histolytica hypothetical protein 0.0079 0.1334 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0955 0.0955
Schistosoma mansoni nuclear receptor 0.0028 0.0313 0.0322
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0799 0.0887
Schistosoma mansoni hypothetical protein 0.0104 0.1853 0.2115
Leishmania major hypothetical protein, conserved 0.0016 0.0067 0.0044
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0395 0.0522
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.0967 0.1355
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.0746 0.1034
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0479 0.0776
Loa Loa (eye worm) hypothetical protein 0.006 0.0955 0.0955
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.006 0.0955 0.1051
Echinococcus multilocularis FTZ F1 alpha 0.006 0.0955 0.1069
Loa Loa (eye worm) hypothetical protein 0.0032 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.006 0.0955 0.1069
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0113 0.2037 0.2916
Echinococcus multilocularis cpg binding protein 0.0068 0.1113 0.1253
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0043 0.0612 0.0612
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0522 0.1031
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.0622 0.0622
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Schistosoma mansoni protein kinase 0.0033 0.0407 0.0431
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0407 0.0407
Brugia malayi CHD4 protein 0.0017 0.0085 0.0062
Mycobacterium tuberculosis Conserved hypothetical protein 0.0186 0.351 0.7392
Brugia malayi Nuclear hormone receptor family member nhr-3 0.006 0.0955 0.0934
Brugia malayi nuclear hormone receptor family member nhr-6 0.0028 0.0313 0.029
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0506 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0955 0.0955
Trypanosoma brucei glucose transporter, putative 0.0032 0.0395 0.0522
Echinococcus granulosus tumor protein p63 0.0357 0.6976 0.8081
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0746 0.1034
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0374 0.6118
Loa Loa (eye worm) hypothetical protein 0.0039 0.0522 0.0522
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0703 0.0775
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0258 0.0483
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0211 0.0872
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0479 0.0644
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0353 0.6898 1
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0037 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0955 0.1069
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0408 0.0651
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0522 0.05
Loa Loa (eye worm) sugar transporter 0.0104 0.1853 0.1853
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.006 0.0955 0.1069
Brugia malayi hypothetical protein 0.0028 0.0313 0.029
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0028 0.0313 0.0316
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.006 0.0955 0.1069
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0474 0.0638
Schistosoma mansoni protein kinase 0.0033 0.0407 0.0431
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0824 0.0917
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0772 0.0856
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.006 0.0955 0.1069
Brugia malayi hypothetical protein 0.0032 0.0382 0.0359
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0037 0.0014
Loa Loa (eye worm) hypothetical protein 0.0039 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.0075 0.1254 0.1254
Loa Loa (eye worm) hypothetical protein 0.0023 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0039 0.0522 0.0522
Brugia malayi Pre-SET motif family protein 0.0221 0.4224 0.4211
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0522 0.1032
Onchocerca volvulus 0.0252 0.484 0.5498
Echinococcus granulosus cpg binding protein 0.0068 0.1113 0.1253
Trichomonas vaginalis chromobox protein, putative 0.007 0.1161 0.2358
Echinococcus granulosus RUN 0.0023 0.0211 0.0203
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0408 0.0427
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0395 0.0768
Trypanosoma brucei glucose transporter, putative 0.0032 0.0395 0.0522
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0408 0.0427
Echinococcus multilocularis Protein lozenge 0.0056 0.0873 0.0974
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0522 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-41 0.006 0.0955 0.0934
Brugia malayi nuclear hormone receptor 0.0028 0.0313 0.029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0032 0.0382 0.0402
Entamoeba histolytica protein kinase, putative 0.0033 0.0407 0.1745
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.1334 0.151
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0395 0.0768
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0395 0.0522
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0211 0.0203
Schistosoma mansoni lipoxygenase 0.0023 0.0211 0.0203
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.1161 0.1161
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0211 0.0201
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.1311 0.267
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1853 0.2115
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0408 0.0651
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0313 0.0322
Leishmania major hypothetical protein, conserved 0.0036 0.0474 0.0638
Schistosoma mansoni hypothetical protein 0.0438 0.8623 1
Trichomonas vaginalis set domain proteins, putative 0.0252 0.484 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.3089 0.3089
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0509 0.055
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0113 0.2037 0.2037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.006 0.0955 0.0934
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0408 0.0427
Onchocerca volvulus 0.0031 0.0364 0.0375
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0028 0.0313 0.0322
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0564 0.1118
Trypanosoma brucei glucose transporter 1E 0.0032 0.0395 0.0522
Leishmania major mitochondrial DNA polymerase beta 0.0353 0.6898 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0211 0.0211
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0407 0.0649
Brugia malayi photoreceptor-specific nuclear receptor 0.006 0.0955 0.0934
Onchocerca volvulus 0.0028 0.0313 0.0316
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Brugia malayi chromobox protein homolog 3 0.0039 0.0536 0.0514
Brugia malayi nuclear hormone receptor family member odr-7 0.0028 0.0313 0.029
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0522 0.1032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0772 0.0856
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0407 0.0431
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.3089 0.4448
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0153 0.0266
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0313 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.006 0.0955 0.0955
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0353 0.6898 1
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0382 0.0359
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0211 0.02
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0078 0.1311 0.6368
Brugia malayi hypothetical protein 0.0023 0.0211 0.0188
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0113 0.2037 0.2916
Loa Loa (eye worm) hypothetical protein 0.0032 0.0382 0.0382
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.0382 0.0402
Brugia malayi Bromodomain containing protein 0.004 0.056 0.0538
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.0382 0.0402
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0353 0.6898 1
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.2037 0.4179
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0479 0.0508
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0211 0.0203
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0395 0.0768
Loa Loa (eye worm) steroid hormone receptor 0.006 0.0955 0.0955
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0189 0.0166
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0522 0.0558
Echinococcus multilocularis protein dispatched 1 0.0068 0.1118 0.126
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0772 0.0856
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0076 0.0046
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0347 0.0361
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0474 0.0769
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.014 0.022
Trypanosoma brucei glucose transporter, putative 0.0032 0.0395 0.0522
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0374 0.0351
Echinococcus granulosus sterol regulatory element binding protein 0.0068 0.1118 0.126
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0065 0.1059 0.1191
Schistosoma mansoni cpg binding protein 0.0062 0.1 0.1122
Trichomonas vaginalis chromobox protein, putative 0.007 0.1161 0.2358
Echinococcus multilocularis chromobox protein 1 0.007 0.1161 0.1309
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.0955 0.0934
Brugia malayi Cytochrome P450 family protein 0.0027 0.0285 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0395 0.0768
Entamoeba histolytica hypothetical protein 0.0079 0.1334 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0037 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0126 0.0208
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.0382 0.0382
Brugia malayi beta-lactamase family protein 0.0039 0.0522 0.05
Schistosoma mansoni bromodomain containing protein 0.007 0.1167 0.1316
Onchocerca volvulus 0.0052 0.0799 0.0872
Schistosoma mansoni steroid hormone receptor ad4bp 0.006 0.0955 0.1069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.006 0.0955 0.0934
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0028 0.0313 0.0322
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0374 0.0351
Loa Loa (eye worm) hypothetical protein 0.006 0.0955 0.0955
Echinococcus multilocularis General substrate transporter 0.009 0.1556 0.1769
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0258 0.0483
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0746 0.1034
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0182 0.0182
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0211 0.0254
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0211 0.0203
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0479 0.0644
Loa Loa (eye worm) hypothetical protein 0.0032 0.0382 0.0382
Brugia malayi hypothetical protein 0.0152 0.2822 0.2805
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0294 0.03
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0395 0.0768
Trypanosoma cruzi ISWI complex protein 0.0016 0.0067 0.0044
Schistosoma mansoni hypothetical protein 0.0016 0.0067 0.0036
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0211 0.0203
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0347 0.0361
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0374 0.0392
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0285 0.0361
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0395 0.0522
Loa Loa (eye worm) hypothetical protein 0.0039 0.0536 0.0536
Loa Loa (eye worm) sugar transporter 0.0015 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0536 0.1061
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.014 0.022
Schistosoma mansoni zinc finger protein 0.0028 0.0313 0.0322
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0824 0.0824
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0522 0.0565
Onchocerca volvulus Bile acid receptor homolog 0.006 0.0955 0.1051
Echinococcus multilocularis protein patched 0.0068 0.1118 0.126
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0211 0.0203
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0076 0.0046
Trypanosoma brucei glucose transporter 2A 0.0032 0.0395 0.0522
Loa Loa (eye worm) nuclear receptor NHR-67 0.0028 0.0313 0.0313
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0522 0.1032
Echinococcus granulosus Nuclear hormone receptor HR96 0.0028 0.0313 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-40 0.006 0.0955 0.0934
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.2037 0.4179
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.006 0.0955 0.0934
Schistosoma mansoni nuclear hormone receptor 0.006 0.0955 0.1069
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0065 0.1059 0.1191
Brugia malayi Nuclear hormone receptor E75 0.0028 0.0313 0.029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0152 0.2822 0.2822
Echinococcus granulosus mitogen activated protein kinase 0.0113 0.2037 0.233
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0522 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.1118 0.2271
Loa Loa (eye worm) hypothetical protein 0.006 0.0955 0.0955
Trypanosoma cruzi ISWI complex protein 0.0016 0.0067 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0037 0.0014
Echinococcus multilocularis zinc finger protein 0.0024 0.0231 0.0226
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0522 0.1032
Brugia malayi Nuclear hormone receptor family member nhr-14 0.006 0.0955 0.0934
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0522 0.1396
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0395 0.0522
Brugia malayi orphan nuclear receptor NR2E1 0.0028 0.0313 0.029
Brugia malayi nuclear receptor RXR 0.0028 0.0313 0.029
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.109 0.1227
Loa Loa (eye worm) hypothetical protein 0.0041 0.0561 0.0561
Mycobacterium ulcerans lipase LipD 0.0039 0.0522 0.1396

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = -74 % Inhibition of cholesterol synthesis in hamster at 10 mg/kg, po after 2 to 4 hrs relative to control ChEMBL. 17764936
Activity (functional) = -15 % Inhibition of cholesterol synthesis in hamster at 10 mg/kg, po after 4 to 6 hrs relative to control ChEMBL. 17764936
AUC (ADMET) = 78.5 ng.hr/ml AUC (0 to infinity) in human plasma at 1 mg administered as single dose ChEMBL. 21183342
AUC (ADMET) = 434 ng.hr/ml AUC (0 to infinity) in human plasma at 5 mg administered as single dose ChEMBL. 21183342
AUC (ADMET) = 1930 ng.hr/ml AUC (0 to infinity) in human plasma at 20 mg administered as single dose ChEMBL. 21183342
AUC (ADMET) = 5110 ng.hr/ml AUC (0 to infinity) in human plasma at 40 mg administered as single dose ChEMBL. 21183342
AUC (ADMET) = 11800 ng.hr/ml AUC (0 to infinity) in human plasma at 80 mg administered as single dose ChEMBL. 21183342
AUC (ADMET) = 25000 ng.hr/ml AUC (0 to infinity) in human plasma at 160 mg administered as single dose ChEMBL. 21183342
Cmax (ADMET) = 33.5 ng/ml Cmax in human plasma at 1 mg administered as single dose ChEMBL. 21183342
Cmax (ADMET) = 196 ng/ml Cmax in human plasma at 5 mg administered as single dose ChEMBL. 21183342
Cmax (ADMET) = 740 ng/ml Cmax in human plasma at 20 mg administered as single dose ChEMBL. 21183342
Cmax (ADMET) = 1770 ng/ml Cmax in human plasma at 40 mg administered as single dose ChEMBL. 21183342
Cmax (ADMET) = 4480 ng/ml Cmax in human plasma at 80 mg administered as single dose ChEMBL. 21183342
Cmax (ADMET) = 6810 ng/ml Cmax in human plasma at 160 mg administered as single dose ChEMBL. 21183342
Drug uptake (ADMET) = 78 % Drug uptake in sandwich-cultured human hepatocytes assessed per mg of protein at 1 uM in presence of rifamycin SV ChEMBL. 21183342
Drug uptake (ADMET) = 7.8 pmol/min/mg Drug uptake in sandwich-cultured human hepatocytes assessed per mg of protein at 1 uM ChEMBL. 21183342
fAUC (ADMET) = 4 ng.hr/ml fAUC (0 to infinity) in human plasma at 1 mg administered as single dose ChEMBL. 21183342
fAUC (ADMET) = 22.1 ng.hr/ml fAUC (0 to infinity) in human plasma at 5 mg administered as single dose ChEMBL. 21183342
fAUC (ADMET) = 98.4 ng.hr/ml fAUC (0 to infinity) in human plasma at 20 mg administered as single dose ChEMBL. 21183342
fAUC (ADMET) = 261 ng.hr/ml fAUC (0 to infinity) in human plasma at 40 mg administered as single dose ChEMBL. 21183342
fAUC (ADMET) = 602 ng.hr/ml fAUC (0 to infinity) in human plasma at 80 mg administered as single dose ChEMBL. 21183342
fAUC (ADMET) = 1280 ng.hr/ml fAUC (0 to infinity) in human plasma at 160 mg administered as single dose ChEMBL. 21183342
FC (ADMET) = 1.4 Drug uptake by human hepatic OATP2B1 transporter expressed in HEK293 cells at 10 uM relative to wild-type HEK293 cells ChEMBL. 21183342
FC (ADMET) = 2.1 Drug uptake by human hepatic OATP2B1 transporter expressed in HEK293 cells at 1 uM relative to wild-type HEK293 cells ChEMBL. 21183342
FC (ADMET) = 2.6 Drug uptake by rat hepatic OATP1B2 transporters expressed in CHO cells at 10 uM relative to wild type CHO cells ChEMBL. 21183342
FC (ADMET) = 2.7 Drug uptake by rat hepatic OATP1A4 transporters expressed in CHO cells at 1 uM relative to wild type CHO cells ChEMBL. 21183342
FC (ADMET) = 2.9 Drug uptake by rat hepatic OATP1B2 transporters expressed in CHO cells at 1 uM relative to wild type CHO cells ChEMBL. 21183342
FC (ADMET) = 3 Drug uptake by rat hepatic OATP1A4 transporters expressed in CHO cells at 10 uM relative to wild type CHO cells ChEMBL. 21183342
FC (ADMET) = 3.6 Drug uptake by rat hepatic OATP1A1 transporters expressed in CHO cells at 1 uM relative to wild type CHO cells ChEMBL. 21183342
FC (ADMET) = 4.2 Drug uptake by rat hepatic OATP1A1 transporters expressed in CHO cells at 10 uM relative to wild type CHO cells ChEMBL. 21183342
FC (ADMET) = 5 Drug uptake by human hepatic OATP1B3 transporter expressed in HEK293 cells at 10 uM relative to wild-type HEK293 cells ChEMBL. 21183342
FC (ADMET) = 11.1 Drug uptake by human hepatic OATP1B3 transporter expressed in HEK293 cells at 1 uM relative to wild-type HEK293 cells ChEMBL. 21183342
FC (ADMET) = 18.4 Drug uptake by human hepatic OATP1B1 transporter expressed in HEK293 cells at 10 uM relative to wild type HEK293 cells ChEMBL. 21183342
FC (ADMET) = 21.6 Drug uptake by human hepatic OATP1B1 transporter expressed in HEK293 cells at 1 uM relative to wild type HEK293 cells ChEMBL. 21183342
fCmax (ADMET) = 1.71 ng/ml fCmax in human plasma at 1 mg administered as single dose ChEMBL. 21183342
fCmax (ADMET) = 10 ng/ml fCmax in human plasma at 5 mg administered as single dose ChEMBL. 21183342
fCmax (ADMET) = 37.7 ng/ml fCmax in human plasma at 20 mg administered as single dose ChEMBL. 21183342
fCmax (ADMET) = 90.3 ng/ml fCmax in human plasma at 40 mg administered as single dose ChEMBL. 21183342
fCmax (ADMET) = 228 ng/ml fCmax in human plasma at 80 mg administered as single dose ChEMBL. 21183342
fCmax (ADMET) = 347 ng/ml fCmax in human plasma at 160 mg administered as single dose ChEMBL. 21183342
IC50 (binding) = 1 nM Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addition measured after 0.75 hrs by beta scintillation counting ChEMBL. 21183342
IC50 (functional) = 1.1 nM Inhibition of cholesterol synthesis in rat hepatocytes ChEMBL. 17764936
IC50 (binding) = 2.5 nM Inhibition of HMG-CoA reductase in rat liver microsomes ChEMBL. 17764936
IC50 (binding) = 2.5 nM Inhibition of HMG-CoA reductase in rat liver microsomes ChEMBL. 17764936
IC50 (functional) = 800 nM Inhibition of cholesterol synthesis in L6 myocytes ChEMBL. 17764936
Inhibition (functional) = -65 % Inhibition of HMG-CoA reductase in human assessed as decrease in AUC (0 to 24 hrs) of mevalonate level in plasma at 80 mg administered as single dose relative to control ChEMBL. 21183342
Inhibition (functional) = -55 % Inhibition of HMG-CoA reductase in human assessed as decrease in AUC (0 to 24 hrs) of mevalonate level in plasma at 160 mg administered as single dose relative to control ChEMBL. 21183342
Inhibition (functional) = -41 % Inhibition of HMG-CoA reductase in human assessed as decrease in AUC (0 to 24 hrs) of mevalonate level in plasma at 40 mg administered as single dose relative to control ChEMBL. 21183342
Inhibition (functional) = -34 % Inhibition of HMG-CoA reductase in human assessed as decrease in AUC (0 to 24 hrs) of mevalonate level in plasma at 20 mg administered as single dose relative to control ChEMBL. 21183342
Inhibition (functional) = -29 % Inhibition of HMG-CoA reductase in human assessed as decrease in AUC (0 to 72 hrs) of mevalonate level in plasma at 80 mg administered as single dose relative to control ChEMBL. 21183342
Inhibition (functional) = -24 % Inhibition of HMG-CoA reductase in human assessed as decrease in AUC (0 to 72 hrs) of mevalonate level in plasma at 160 mg administered as single dose relative to control ChEMBL. 21183342
Inhibition (functional) = -17 % Inhibition of HMG-CoA reductase in human assessed as decrease in AUC (0 to 72 hrs) of mevalonate level in plasma at 20 mg administered as single dose relative to control ChEMBL. 21183342
Inhibition (functional) = -16 % Inhibition of HMG-CoA reductase in human assessed as decrease in AUC (0 to 24 hrs) of mevalonate level in plasma at 1 mg administered as single dose relative to control ChEMBL. 21183342
Inhibition (functional) = -13 % Inhibition of HMG-CoA reductase in human assessed as decrease in AUC (0 to 24 hrs) of mevalonate level in plasma at 5 mg administered as single dose relative to control ChEMBL. 21183342
Inhibition (functional) = -8 % Inhibition of HMG-CoA reductase in human assessed as decrease in AUC (0 to 72 hrs) of mevalonate level in plasma at 1 mg administered as single dose relative to control ChEMBL. 21183342
Inhibition (functional) = -3 % Inhibition of HMG-CoA reductase in human assessed as decrease in AUC (0 to 72 hrs) of mevalonate level in plasma at 40 mg administered as single dose relative to control ChEMBL. 21183342
Inhibition (functional) = 3 % Inhibition of HMG-CoA reductase in human assessed as decrease in AUC (0 to 72 hrs) of mevalonate level in plasma at 5 mg administered as single dose relative to control ChEMBL. 21183342
T1/2 (ADMET) = 2.55 hr Terminal half life in human plasma at 1 mg administered as single dose ChEMBL. 21183342
T1/2 (ADMET) = 4.54 hr Terminal half life in human plasma at 5 mg administered as single dose ChEMBL. 21183342
T1/2 (ADMET) = 5.27 hr Terminal half life in human plasma at 20 mg administered as single dose ChEMBL. 21183342
T1/2 (ADMET) = 6.28 hr Terminal half life in human plasma at 80 mg administered as single dose ChEMBL. 21183342
T1/2 (ADMET) = 8.57 hr Terminal half life in human plasma at 40 mg administered as single dose ChEMBL. 21183342
T1/2 (ADMET) = 8.87 hr Terminal half life in human plasma at 160 mg administered as single dose ChEMBL. 21183342

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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