Detailed information for compound 513837

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.36 | Formula: C21H14N4O4
  • H donors: 0 H acceptors: 4 LogP: 2.53 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cnn2c1n[n+]([O-])c1c2cc(cc1)OCc1ccccc1)c1ccco1
  • InChi: 1S/C21H14N4O4/c26-20(19-7-4-10-28-19)16-12-22-24-18-11-15(29-13-14-5-2-1-3-6-14)8-9-17(18)25(27)23-21(16)24/h1-12H,13H2
  • InChiKey: DDYPSLHKAAFIKL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0039 0.0094 0.0247
Loa Loa (eye worm) doublecortin family protein 0.002 0.0013 0.0026
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0007
Echinococcus granulosus metabotropic glutamate receptor 2 0.0138 0.0535 0.0534
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0682 0.2958 0.7753
Echinococcus multilocularis receptor type guanylyl cyclase 0.0027 0.0044 0.0043
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0019 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0039 0.0098 0.0097
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0083 0.0188
Schistosoma mansoni phospholipase A-2-activating protein 0.0024 0.0028 0.0062
Toxoplasma gondii cathepsin CPL 0.0018 0.0003 0.0017
Loa Loa (eye worm) CUTiclin-Like family member 0.0042 0.0109 0.028
Toxoplasma gondii aldehyde dehydrogenase 0.0249 0.1031 1
Echinococcus granulosus voltage dependent calcium channel subunit 0.103 0.4506 0.4505
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0189 0.0433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0039 0.0098 0.3331
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0043 0.0867
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0228 0.2499
Plasmodium vivax glutathione reductase, putative 0.0051 0.0149 0.3076
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0053 0.0139
Plasmodium falciparum cysteine repeat modular protein 1 0.0023 0.0024 0.0785
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0018 0.0004 0.0004
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0057 0.0176 0.0405
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0072 0.0759
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0007
Schistosoma mansoni regulator of G protein signaling 0.0057 0.0176 0.0405
Schistosoma mansoni hypothetical protein 0.0047 0.013 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0053 0.0139
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0039 0.0098 0.0097
Schistosoma mansoni DNA helicase recq5 0.0039 0.0098 0.0224
Schistosoma mansoni axis inhibition protein axin 0.0057 0.0176 0.0405
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0483 0.1117
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0003 0.0059
Onchocerca volvulus 0.0135 0.0522 0.1194
Brugia malayi PXA domain containing protein 0.0057 0.0176 0.0461
Schistosoma mansoni DNA helicase recq1 0.0039 0.0098 0.0224
Echinococcus granulosus alkaline phosphatase 0.0317 0.1334 0.1333
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0005
Schistosoma mansoni lamin 0.0135 0.0522 0.1207
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0317 0.1334 0.1333
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Onchocerca volvulus 0.0126 0.0483 0.1105
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0081 0.078
Leishmania major hypothetical protein, conserved 0.0035 0.0079 0.0755
Schistosoma mansoni hypothetical protein 0.0174 0.0698 0.1615
Brugia malayi hypothetical protein 0.002 0.0013 0.0033
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0202 0.2207
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0179 0.1962
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0053 0.0139
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0249 0.1031 1
Echinococcus granulosus lamin 0.0135 0.0522 0.0521
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0126 0.0483 0.0482
Toxoplasma gondii microneme protein MIC2 0.0042 0.0109 0.1053
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0023 0.0024 0.0474
Mycobacterium ulcerans aldehyde dehydrogenase 0.0249 0.1031 1
Echinococcus granulosus excitatory amino acid transporter 3 0.037 0.157 0.1569
Brugia malayi Protein kinase domain containing protein 0.0023 0.0024 0.0062
Echinococcus granulosus geminin 0.0174 0.0698 0.0697
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0057 0.0176 0.0405
Echinococcus granulosus glutamate receptor 2 0.0085 0.0299 0.0298
Echinococcus granulosus axis inhibition protein axin 0.0057 0.0176 0.0175
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0003 0.0002
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0258 0.1072 0.248
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0057 0.0177 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0249 0.1031 0.2386
Brugia malayi Cache domain containing protein 0.0456 0.1951 0.5115
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0176 0.0402
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0834 0.3635 0.3635
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0189 0.1202
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0176 0.0402
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0258 0.1072 0.1071
Schistosoma mansoni loxhd1 0.002 0.0013 0.0027
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0249 0.1031 0.6568
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0483 0.1117
Brugia malayi Kringle domain containing protein 0.0023 0.0024 0.0062
Echinococcus granulosus glutamate receptor subunit protein glur 0.0026 0.0039 0.0038
Loa Loa (eye worm) 6-phosphofructokinase 0.0222 0.0911 0.2384
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0075 0.0171
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0189 0.0433
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0053 0.0121
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0083 0.0188
Brugia malayi Regulator of G protein signaling domain containing protein 0.0057 0.0176 0.0461
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.0911 0.2092
Schistosoma mansoni tyrosine kinase 0.0027 0.0044 0.01
Schistosoma mansoni rab6-interacting 0.002 0.0013 0.0027
Treponema pallidum glutamate/aspartate transporter 0.0164 0.0652 0.1406
Brugia malayi ecdysteroid receptor 0.0029 0.0053 0.0139
Brugia malayi Regulator of G protein signaling domain containing protein 0.0057 0.0176 0.0461
Brugia malayi Receptor family ligand binding region containing protein 0.0027 0.0044 0.0116
Mycobacterium ulcerans epimerase 0.0022 0.0019 0.018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0228 0.2499
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0228 0.2499
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0053 0.0052
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.044 0.4715
Trypanosoma brucei WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0024 0.0028 0.0294
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0083 0.0898
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0134 0.052 0.1364
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0179 0.1139
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.044 0.2799
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0053 0.0139
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0135 0.0522 0.1363
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0053 0.0052
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0039 0.0098 0.0097
Leishmania major cathepsin L-like protease 0.0018 0.0003 0.0017
Trypanosoma brucei trypanothione reductase 0.0051 0.0149 0.1629
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0101 0.1094
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0003 0.0004
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0053 0.0121
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0179 0.0179
Schistosoma mansoni ap endonuclease 0.0058 0.0179 0.0414
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0.0004 0.0022
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0265 0.11 0.1099
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.0044 0.0043
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.1795 0.1794
Schistosoma mansoni tyrosine kinase 0.0027 0.0044 0.01
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0498 0.2138 0.4951
Giardia lamblia DINP protein human, muc B family 0.0021 0.0014 0.0681
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0101 0.0967
Brugia malayi Cytochrome P450 family protein 0.0074 0.0252 0.0661
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0098 0.0256
Plasmodium vivax vivapain-2 0.0018 0.0003 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0081 0.0185
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0026 0.0039 0.0038
Echinococcus granulosus RUN 0.002 0.0013 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0053 0.0052
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0252 0.0655
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.0498 0.3167
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0454
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0123 0.1337
Brugia malayi hypothetical protein 0.0228 0.0939 0.2462
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0044 0.0109
Schistosoma mansoni lamin 0.0135 0.0522 0.1207
Onchocerca volvulus 0.003 0.0054 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0228 0.2499
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0.0004 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0101 0.1094
Schistosoma mansoni glutamate receptor NMDA 0.0085 0.0299 0.069
Echinococcus multilocularis regulator of G protein signaling 7 0.0057 0.0176 0.0175
Leishmania major hypothetical protein, conserved 0.0027 0.0043 0.0406
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0109 0.0287
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0035 0.0079 0.0855
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0042 0.0107 0.2207
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0053 0.0121
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0019 0.0051
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.0024 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0014 0.0141
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0021 0.0014 0.0081
Echinococcus granulosus Excitatory amino acid transporter 0.037 0.157 0.1569
Echinococcus multilocularis axis inhibition protein axin 0.0057 0.0176 0.0175
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0189 0.0433
Toxoplasma gondii PUL domain-containing protein 0.0035 0.0079 0.0755
Echinococcus granulosus neutral amino acid transporter A 0.037 0.157 0.1569
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0109 0.0287
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0054 0.0134
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0021 0.0014 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0053 0.0132
Echinococcus granulosus intestinal type alkaline phosphatase 0.0317 0.1334 0.1333
Brugia malayi Glutamate receptor 1 precursor 0.0057 0.0177 0.0464
Echinococcus granulosus metabotropic glutamate receptor 5 0.0196 0.0795 0.0794
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0176 0.0405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0053 0.0121
Entamoeba histolytica recQ family helicase, putative 0.0045 0.0123 0.1321
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0132
Echinococcus multilocularis Excitatory amino acid transporter 0.037 0.157 0.1569
Onchocerca volvulus 0.0042 0.0109 0.0246
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0026 0.0039 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0101 0.1094
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1058 0.4633 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0228 0.2499
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0018 0.0004 0.0008
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0109 0.0287
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0042 0.0109 0.0287
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0035 0.0079 0.0179
Echinococcus multilocularis voltage dependent calcium channel subunit 0.103 0.4506 0.4505
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Treponema pallidum glutamate transporter 0.0164 0.0652 0.1406
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0043 0.1438
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Schistosoma mansoni rotamase 0.0034 0.0075 0.0172
Echinococcus multilocularis RUN 0.002 0.0013 0.0012
Giardia lamblia Sgs1 DNA helicase, putative 0.0039 0.0098 0.5135
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Echinococcus granulosus regulator of G protein signaling 7 0.0057 0.0176 0.0175
Echinococcus multilocularis regulator of G protein signaling 3 0.0057 0.0176 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0053 0.0132
Schistosoma mansoni lipoxygenase 0.0057 0.0175 0.0403
Brugia malayi steroid hormone receptor 0.0029 0.0053 0.0139
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0072 0.078
Brugia malayi Pre-SET motif family protein 0.0126 0.0483 0.1266
Echinococcus granulosus dnaJ subfamily B 0.0421 0.1795 0.1794
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0109 0.1175
Schistosoma mansoni thyroid hormone receptor 0.0294 0.1231 0.2849
Leishmania major ATP-dependent phosphofructokinase 0.0222 0.0911 0.8836
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0179 0.0471
Brugia malayi hypothetical protein 0.0478 0.2048 0.5369
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0222 0.0911 1
Schistosoma mansoni ap endonuclease 0.0058 0.0179 0.0414
Loa Loa (eye worm) glutamate receptor 1 0.0057 0.0177 0.0458
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0317 0.1334 0.1333
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0454
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0101 0.1094
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0021 0.0014 0.0027
Entamoeba histolytica hypothetical protein 0.0057 0.0176 0.1904
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0053 0.0121
Echinococcus granulosus regulator of G protein signaling 3 0.0057 0.0176 0.0175
Toxoplasma gondii phosphofructokinase PFKII 0.006 0.0189 0.183
Loa Loa (eye worm) glutamate receptor 0.0058 0.0182 0.047
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0057 0.0176 0.0454
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0044 0.0109
Mycobacterium ulcerans hydrolase 0.0018 0.0004 0.0034
Echinococcus multilocularis regulator of G protein signaling 7 0.0057 0.0176 0.0175
Echinococcus multilocularis expressed protein 0.0034 0.0075 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0003 0.0004
Onchocerca volvulus 0.0053 0.0159 0.0359
Brugia malayi Sulfatase family protein 0.0018 0.0004 0.0012
Mycobacterium ulcerans arylsulfatase, AslA 0.0018 0.0004 0.0034
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0083 0.0292 0.0764
Trypanosoma brucei unspecified product 0.0034 0.0072 0.078
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.024 0.263
Entamoeba histolytica hypothetical protein 0.0039 0.0094 0.1007
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0081 0.0213
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0003 0.0019
Echinococcus granulosus glutamate receptor 2 0.0058 0.0182 0.0181
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0003 0.0002
Echinococcus granulosus GPCR family 3 C terminal 0.0024 0.0029 0.0029
Loa Loa (eye worm) WD domain-containing protein 0.0024 0.0028 0.0066
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0094 0.0216
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0081 0.4263
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0081 0.008
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0053 0.0116
Echinococcus multilocularis cysteine protease 0.0018 0.0003 0.0002
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0081 0.0883
Loa Loa (eye worm) hypothetical protein 0.0036 0.0081 0.0206
Treponema pallidum ATP-dependent DNA helicase 0.002 0.0012 0.0023
Echinococcus multilocularis cpg binding protein 0.0031 0.0061 0.006
Schistosoma mansoni cpg binding protein 0.0031 0.0061 0.014
Entamoeba histolytica hypothetical protein 0.0039 0.0094 0.1007
Mycobacterium tuberculosis Probable sulfatase 0.0018 0.0004 0.0022
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0317 0.1334 0.1333
Plasmodium falciparum glutathione reductase 0.0051 0.0149 0.5101
Loa Loa (eye worm) hypothetical protein 0.0053 0.0159 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0053 0.0121
Leishmania major extracellular receptor, putative 0.0027 0.0044 0.042
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0177 0.0408
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.024 0.2324
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0101 0.1094
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0101 0.0967
Echinococcus granulosus neutral amino acid transporter A 0.037 0.157 0.1569
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0123 0.1337
Echinococcus granulosus axis inhibition protein axin 0.0057 0.0176 0.0175
Echinococcus granulosus excitatory amino acid transporter 2 0.037 0.157 0.1569
Schistosoma mansoni inositol monophosphatase 0.0036 0.0083 0.0189
Plasmodium vivax vivapain-2 0.0018 0.0003 0.0036
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.0939 0.0938
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0013 0.0012
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0222 0.0911 0.5804
Entamoeba histolytica phosphofructokinase, putative 0.0222 0.0911 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0164 0.0652 0.0652
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0003 0.0004
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0123 0.028
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0098 0.094
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0179 0.1962
Onchocerca volvulus 0.0029 0.0053 0.0116
Echinococcus granulosus beta-adrenergic receptor kinase 0.0057 0.0176 0.0175
Schistosoma mansoni glutamate receptor kainate 0.0118 0.0447 0.1033
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.024 0.0239
Schistosoma mansoni hypothetical protein 0.0532 0.229 0.5301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0228 0.2499
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0003 0.0004
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0013 0.04
Schistosoma mansoni blooms syndrome DNA helicase 0.0046 0.0129 0.0296
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0053 0.0052
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0053 0.0132
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0053 0.0121
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0258 0.1072 0.2804
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0104 0.1
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0042 0.0109 0.2251
Chlamydia trachomatis glutamate symporter 0.037 0.157 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0057 0.0176 0.0405
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0053 0.0052
Echinococcus multilocularis expressed protein 0.1109 0.4857 0.4856
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0061 0.0193 0.6619
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0189 0.6486
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0454
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0053 0.0139
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0179 0.041
Schistosoma mansoni hypothetical protein 0.0026 0.0039 0.0088
Echinococcus multilocularis axis inhibition protein axin 0.0057 0.0176 0.0175
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0176 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Schistosoma mansoni hypothetical protein 0.0174 0.0698 0.1615
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0083 0.088
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0003 0.0059
Schistosoma mansoni 6-phosphofructokinase 0.0222 0.0911 0.2109
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0039 0.0098 0.0249
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0109 0.0287
Schistosoma mansoni serine-rich repeat protein 0.0532 0.229 0.5301
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0055
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0026 0.0039 0.0038
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0192 0.1854
Onchocerca volvulus Excitatory amino acid transporter homolog 0.037 0.157 0.3603
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.0911 0.2092
Brugia malayi follicle stimulating hormone receptor 0.0481 0.2064 0.541
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.006 0.0189 1
Onchocerca volvulus 0.0042 0.0109 0.0246
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0317 0.1334 0.1333
Onchocerca volvulus 0.002 0.0013 0.0023
Brugia malayi Doublecortin family protein 0.002 0.0013 0.0033
Loa Loa (eye worm) hypothetical protein 0.0065 0.0212 0.0549
Brugia malayi cytoplasmic intermediate filament protein 0.0072 0.0244 0.0639
Brugia malayi hypothetical protein 0.0027 0.0043 0.0112
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0057 0.0176 0.0402
Onchocerca volvulus 0.0135 0.0522 0.1194
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0026
Brugia malayi hypothetical protein 0.0262 0.1087 0.285
Echinococcus multilocularis neutral amino acid transporter A 0.037 0.157 0.1569
Echinococcus multilocularis 6 phosphofructokinase 0.0222 0.0911 0.091
Schistosoma mansoni glutamate receptor kainate 0.0118 0.0447 0.1033
Entamoeba histolytica hypothetical protein 0.0039 0.0094 0.1007
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0003 0.0002
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0057 0.0176 0.0454
Loa Loa (eye worm) CUTiclin family member 0.0042 0.0109 0.028
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0126 0.0483 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0228 0.2499
Echinococcus multilocularis regulator of G protein signaling 3 0.0057 0.0176 0.0175
Mycobacterium ulcerans 6-phosphofructokinase 0.0222 0.0911 0.8836
Echinococcus multilocularis excitatory amino acid transporter 2 0.037 0.157 0.1569
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0145 0.0569 0.0568
Echinococcus multilocularis regulator of G protein signaling 0.0057 0.0176 0.0175
Leishmania major cathepsin L-like protease 0.0069 0.0228 0.2208
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.037 0.157 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.024 0.063
Toxoplasma gondii exonuclease III APE 0.0058 0.0179 0.1733
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0101 0.1094
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0179 0.3704
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.044 0.2799
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0013 0.0012
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0169 0.0673 0.1556
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0081 0.008
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0027 0.0044 0.0096
Loa Loa (eye worm) hypothetical protein 0.0126 0.0483 0.126
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0249 0.1031 0.103
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0072 0.0686
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Brugia malayi 6-phosphofructokinase 0.0222 0.0911 0.2389
Brugia malayi nuclear receptor NHR-88 0.0029 0.0053 0.0139
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0988 0.4319 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0481 0.2064 0.5407
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0003 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0249 0.1031 1
Entamoeba histolytica hypothetical protein 0.0042 0.0109 0.1175
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0003 0.0002
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0012 0.0105
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0454
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0454
Echinococcus multilocularis musashi 0.0135 0.0522 0.0521
Brugia malayi regulator of G-protein signaling rgs-7 0.0057 0.0176 0.0461
Echinococcus multilocularis GPCR, family 3, C terminal 0.0024 0.0029 0.0029
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0228 0.2499
Trichomonas vaginalis rotamase, putative 0.0034 0.0075 0.0171
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0456 0.1951 0.5112
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0024
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0179 0.6143
Brugia malayi 6-phosphofructokinase 0.0222 0.0911 0.2389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.052
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0083 0.0793
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0053 0.0139
Echinococcus granulosus excitatory amino acid transporter 2 0.037 0.157 0.1569
Schistosoma mansoni regulator of G protein signaling 0.0057 0.0176 0.0405
Leishmania major cathepsin L-like protease 0.0018 0.0003 0.0017
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0012 0.0119
Brugia malayi hypothetical protein 0.0042 0.0109 0.0287
Echinococcus granulosus leukotriene A 4 hydrolase 0.0258 0.1072 0.1071
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.044 0.2799
Schistosoma mansoni survival motor neuron protein 0.0047 0.013 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0053 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0024 0.0251
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0051 0.0151 0.039
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0083 0.0793
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2264 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0094 0.0093
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0053 0.0052
Echinococcus multilocularis neutral amino acid transporter A 0.037 0.157 0.1569
Brugia malayi nuclear hormone receptor 0.0029 0.0053 0.0139
Schistosoma mansoni regulator of G protein signaling 0.0057 0.0176 0.0405
Schistosoma mansoni polycystin 1-related 0.002 0.0013 0.0027
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.006 0.0189 0.2056
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0081 0.008
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0044 0.0109
Trichomonas vaginalis set domain proteins, putative 0.0995 0.4352 1
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0008 0.0062
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.024 0.0624
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0013 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0101 0.1094
Schistosoma mansoni metabotropic glutamate receptor 0.0086 0.0304 0.0702
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0189 0.3911
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0024 0.0029 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0228 0.2499
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0083 0.0793
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.024 0.263
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0007
Echinococcus multilocularis cysteine protease 0.0018 0.0003 0.0002
Chlamydia trachomatis neutral amino acid transporter 0.0164 0.0652 0.4153
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0053 0.0139
Brugia malayi Glutamate receptor 2 precursor 0.0057 0.0177 0.0464
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0072 0.0777
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0222 0.0511
Brugia malayi PXA domain containing protein 0.0057 0.0176 0.0461
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0292 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Echinococcus granulosus expressed protein 0.0034 0.0075 0.0074
Echinococcus multilocularis beta adrenergic receptor kinase 0.0057 0.0176 0.0175
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0072 0.0777
Echinococcus multilocularis geminin 0.0174 0.0698 0.0697
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0149 0.0945
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0189 0.0433
Brugia malayi hypothetical protein 0.0119 0.0451 0.1181
Schistosoma mansoni inositol monophosphatase 0.0036 0.0083 0.0189
Entamoeba histolytica hypothetical protein 0.0057 0.0176 0.1904
Brugia malayi metabotropic glutamate receptor type 2 0.0086 0.0304 0.0796
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0042 0.0109 0.1053
Brugia malayi Guanylyl cyclase protein 23 0.0027 0.0044 0.0116
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.0498 0.5362
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0043 0.1438
Schistosoma mansoni hypothetical protein 0.0023 0.0024 0.0053
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.0498 0.3167
Mycobacterium ulcerans sulfatase 0.0018 0.0004 0.0034
Echinococcus multilocularis Excitatory amino acid transporter 0.037 0.157 0.1569
Treponema pallidum hypothetical protein 0.0042 0.0109 0.0234
Entamoeba histolytica recQ family DNA helicase 0.002 0.0012 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.037 0.157 0.1569
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0043 0.0459
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0053 0.0132
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0179 0.0179
Entamoeba histolytica elongation factor-2 kinase, putative 0.0042 0.0109 0.1175
Echinococcus granulosus lamin dm0 0.0135 0.0522 0.0521
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0083 0.0082
Echinococcus granulosus histone lysine methyltransferase setb 0.0126 0.0483 0.0482
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0066 0.0414
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0003 0.0004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0053 0.0052
Schistosoma mansoni protein kinase 0.0027 0.0044 0.01
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0164 0.0652 0.1509
Echinococcus multilocularis nmda type glutamate receptor 0.0047 0.013 0.0129
Echinococcus multilocularis glutamate receptor 2 0.0057 0.0177 0.0176
Toxoplasma gondii kringle domain-containing protein 0.0023 0.0024 0.0222
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0042 0.0109 0.028
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0001 0.0002
Echinococcus granulosus 6 phosphofructokinase 0.0222 0.0911 0.091
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0085 0.0299 0.0298
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0003 0.0017
Loa Loa (eye worm) phosphofructokinase 0.0222 0.0911 0.2384
Echinococcus granulosus atrial natriuretic peptide receptor 0.0027 0.0044 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Treponema pallidum 76K protein 0.0042 0.0109 0.0234
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0053 0.0116
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0066
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0149 0.0148
Brugia malayi regulator of G-protein signaling egl-10 0.0057 0.0176 0.0461
Brugia malayi Receptor family ligand binding region containing protein 0.0051 0.0151 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0053 0.0139
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0053 0.0139
Loa Loa (eye worm) PXA domain-containing protein 0.0057 0.0176 0.0454
Brugia malayi Thioredoxin reductase 0.0051 0.0149 0.0391
Schistosoma mansoni hypothetical protein 0.002 0.0013 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0053 0.0121
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0042 0.0109 0.028
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0177 0.0408
Echinococcus multilocularis sodium:dicarboxylate symporter 0.037 0.157 0.1569
Echinococcus granulosus bloom syndrome protein 0.0066 0.0218 0.0217
Giardia lamblia Hypothetical protein 0.0018 0.0004 0.0186
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0081 0.0186
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0179 0.9471
Echinococcus granulosus collagen alpha 1VII chain 0.0042 0.0109 0.0109
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0249 0.1031 0.103
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0179 0.1733
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0179 0.041
Leishmania major cathepsin L-like protease 0.0069 0.0228 0.2208
Mycobacterium tuberculosis Possible hydrolase 0.0018 0.0004 0.0022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0109
Toxoplasma gondii thioredoxin reductase 0.0051 0.0149 0.1439
Plasmodium falciparum thioredoxin reductase 0.0051 0.0149 0.5101
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0035 0.0079 0.0855
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.037 0.157 0.3633
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.0911 0.2092
Loa Loa (eye worm) hypothetical protein 0.0196 0.0795 0.2078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0228 0.2499
Schistosoma mansoni rab6-interacting 0.002 0.0013 0.0027
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0164 0.0652 0.0652
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0053 0.0116
Chlamydia trachomatis glutamine binding protein 0.0021 0.0014 0.0081
Onchocerca volvulus 0.0042 0.0109 0.0246
Toxoplasma gondii 6-phosphofructokinase 0.006 0.0189 0.183
Echinococcus multilocularis excitatory amino acid transporter 3 0.037 0.157 0.1569
Echinococcus multilocularis excitatory amino acid transporter 2 0.037 0.157 0.1569
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0164 0.0652 0.1509
Loa Loa (eye worm) hypothetical protein 0.0051 0.0151 0.039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0249 0.1031 1
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0109
Brugia malayi Bloom's syndrome protein homolog 0.0066 0.0218 0.0572
Brugia malayi hypothetical protein 0.0057 0.0176 0.0461
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0042 0.0109 0.3733
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0072 0.0777
Plasmodium vivax thrombospondin-related anonymous protein 0.0042 0.0109 0.2251
Loa Loa (eye worm) glutathione reductase 0.0051 0.0149 0.0384
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0019 0.018
Trichomonas vaginalis DNA helicase recq, putative 0.0066 0.0218 0.05
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0109 0.2251
Echinococcus multilocularis glutamate receptor 2 0.0085 0.0299 0.0298
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0057 0.0176 0.0175
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.0498 0.3167
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0087 0.0309 0.0308
Schistosoma mansoni hypothetical protein 0.0042 0.0109 0.0251
Trichomonas vaginalis 6-phosphofructokinase, putative 0.006 0.0189 0.0433
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0123 0.1182
Echinococcus multilocularis glutamate receptor 2 0.0058 0.0182 0.0181
Schistosoma mansoni axis inhibition protein axin 0.0057 0.0176 0.0405
Brugia malayi WD domain containing protein 0.0035 0.0079 0.0206
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0109
Leishmania major cathepsin L-like protease 0.0018 0.0003 0.0017
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0101 0.0229
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Schistosoma mansoni metabotropic glutamate receptor 0.0138 0.0535 0.1237
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0109 0.0287
Echinococcus granulosus phospholipase A 2 activating protein 0.0035 0.0079 0.0078
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0042 0.0109 0.0249
Schistosoma mansoni thyroid hormone receptor 0.0294 0.1231 0.2849
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Schistosoma mansoni hypothetical protein 0.0421 0.1795 0.4155
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0019 0.0118
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0021 0.0014 0.0027
Entamoeba histolytica hypothetical protein 0.0027 0.0044 0.0457
Trichomonas vaginalis DNA helicase recq1, putative 0.0066 0.0218 0.05
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0189 0.6486
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Echinococcus multilocularis lamin dm0 0.0135 0.0522 0.0521
Leishmania major DNA polymerase kappa, putative 0.0021 0.0014 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0101 0.1094
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0065 0.0212 0.0211
Leishmania major cathepsin L-like protease 0.0018 0.0003 0.0017
Schistosoma mansoni aldehyde dehydrogenase 0.0249 0.1031 0.2386
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0132
Echinococcus granulosus tyrosine kinase 0.0027 0.0044 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0003 0.0004
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0042 0.0109 0.0109
Echinococcus multilocularis lamin 0.0135 0.0522 0.0521
Echinococcus granulosus cpg binding protein 0.0031 0.0061 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.006 0.0189 0.0407
Echinococcus granulosus receptor type guanylyl cyclase 0.0027 0.0044 0.0043
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.024 0.2616
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0053 0.0052
Loa Loa (eye worm) RGS-3 protein 0.0057 0.0176 0.0454
Echinococcus multilocularis thyroid hormone receptor alpha 0.0294 0.1231 0.123
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0053 0.0121
Loa Loa (eye worm) runx1 0.006 0.0189 0.0489
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Mycobacterium ulcerans arylsulfatase AtsD 0.0018 0.0004 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0053 0.0139
Onchocerca volvulus 0.0042 0.0109 0.0246
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0149 0.1629
Schistosoma mansoni lozenge 0.006 0.0189 0.0435
Echinococcus granulosus intermediate filament protein 0.0135 0.0522 0.0521
Brugia malayi hypothetical protein 0.002 0.0013 0.0033
Echinococcus granulosus tumor protein p63 0.0363 0.1537 0.1536
Echinococcus granulosus neutral amino acid transporter 0.037 0.157 0.1569
Schistosoma mansoni regulator of G protein signaling 0.0057 0.0176 0.0405
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0109 0.1175
Brugia malayi Intermediate filament tail domain containing protein 0.0135 0.0522 0.1369
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0083 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0053 0.0052
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0189 0.3911
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0013 0.0241
Loa Loa (eye worm) hypothetical protein 0.0135 0.0522 0.1363
Schistosoma mansoni hypothetical protein 0.0024 0.0029 0.0066
Echinococcus granulosus cathepsin l1 0.0018 0.0003 0.0002
Onchocerca volvulus 0.0042 0.0109 0.0246
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0081 0.0185
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0098 0.094
Onchocerca volvulus 0.002 0.0013 0.0023
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0075 0.0197
Schistosoma mansoni ATP-binding cassette transporter 0.0057 0.0177 0.0408
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0179 0.1947
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0228 0.2499
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0027 0.0044 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0176 0.0402
Onchocerca volvulus 0.0042 0.0109 0.0246
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0003 0.0004
Schistosoma mansoni cpg binding protein 0.003 0.0054 0.0122
Onchocerca volvulus 0.0027 0.0044 0.0096
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0874 0.3815 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0145 0.0569 0.0568
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0057 0.0176 0.0454
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0175 0.0174
Brugia malayi Inositol-1 0.0036 0.0083 0.0217
Leishmania major trypanothione reductase 0.0051 0.0149 0.1439
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0057 0.0143
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0043 0.0459
Loa Loa (eye worm) hypothetical protein 0.0057 0.0176 0.0454
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0083 0.0521
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0176 0.0402
Echinococcus granulosus sodium:dicarboxylate symporter 0.037 0.157 0.1569
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0026
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0013 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0053 0.0052
Echinococcus granulosus Regulator of G protein signaling 20 0.0057 0.0176 0.0175
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0159 0.0365
Loa Loa (eye worm) intermediate filament protein 0.0135 0.0522 0.1363
Onchocerca volvulus 0.0023 0.0024 0.0049
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.044 0.2799
Echinococcus multilocularis Protein lozenge 0.006 0.0189 0.0188
Echinococcus granulosus regulator of G protein signaling 3 0.0057 0.0176 0.0175
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0109 0.0287
Loa Loa (eye worm) hypothetical protein 0.0083 0.0292 0.0758
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0003 0.0059
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0138 0.0535 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0057 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Schistosoma mansoni hypothetical protein 0.0039 0.0094 0.0216
Echinococcus multilocularis phospholipase A 2 activating protein 0.0035 0.0079 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.0911 0.2092
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0053 0.0139
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0083 0.0292 0.1853
Loa Loa (eye worm) hypothetical protein 0.0478 0.2048 0.5365
Trichomonas vaginalis rotamase, putative 0.0034 0.0072 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0065 0.0212 0.0211
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0053 0.0139
Leishmania major hypothetical protein, conserved 0.0023 0.0024 0.0222
Toxoplasma gondii phosphofructokinase domain-containing protein 0.006 0.0189 0.183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0053 0.0132
Loa Loa (eye worm) excitatory amino acid transporter 0.037 0.157 0.411
Toxoplasma gondii endonuclease IV APN 0.0083 0.0292 0.2822
Echinococcus granulosus expressed protein 0.1109 0.4857 0.4856
Schistosoma mansoni alkaline phosphatase 0.0317 0.1334 0.3088
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0189 0.1202
Brugia malayi Excitatory amino acid transporter 0.037 0.157 0.4115
Echinococcus granulosus Excitatory amino acid transporter 0.037 0.157 0.1569
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0179 0.1139
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0228 0.2499
Brugia malayi hypothetical protein 0.0057 0.0176 0.0461
Echinococcus granulosus regulator of G protein signaling 7 0.0057 0.0176 0.0175
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.024 0.0555
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0012 0.0025
Schistosoma mansoni z-protein (S1r protein) 0.0057 0.0176 0.0405
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0149 0.0148
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0003 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0053 0.0139
Loa Loa (eye worm) hypothetical protein 0.0228 0.0939 0.2457
Entamoeba histolytica phosphofructokinase, putative 0.0222 0.0911 1
Brugia malayi Zona pellucida-like domain containing protein 0.0042 0.0109 0.0287
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0083 0.0188
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0081 0.0883
Brugia malayi Zona pellucida-like domain containing protein 0.0042 0.0109 0.0287
Echinococcus granulosus dna polymerase kappa 0.004 0.0101 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Loa Loa (eye worm) inositol-1 0.0036 0.0083 0.021
Schistosoma mansoni lipoxygenase 0.002 0.0013 0.0027
Brugia malayi von Willebrand Factor 0.0042 0.0109 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0176 0.0402
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Echinococcus granulosus nmda type glutamate receptor 0.0047 0.013 0.0129
Plasmodium falciparum thrombospondin-related anonymous protein 0.0042 0.0109 0.3733
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0042 0.0109 0.3733
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0163 0.1779
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0003 0.0007
Mycobacterium ulcerans endonuclease IV 0.0083 0.0292 0.2822
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0222 0.0911 0.1965
Brugia malayi hypothetical protein 0.0027 0.0044 0.0116
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0317 0.1334 0.1333
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0019 0.0008 0.0153
Brugia malayi Pre-SET motif family protein 0.0874 0.3815 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0057 0.0176 0.0461
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0109 0.0287
Schistosoma mansoni intermediate filament proteins 0.0135 0.0522 0.1207
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0101 0.1094
Onchocerca volvulus Poor gastrulation protein homolog 0.0024 0.0029 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0057 0.0618
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0098 0.0256
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0024 0.0055
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0083 0.0898
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0126 0.0483 0.4679
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0179 0.0464
Trypanosoma cruzi extracellular receptor, putative 0.0027 0.0044 0.0475
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0053 0.0132
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0132
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0132
Onchocerca volvulus 0.0995 0.4352 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0057 0.0176 0.0461
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0175 0.0174
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0081 0.008
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0083 0.0898
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0003 0.0004
Entamoeba histolytica phosphofructokinase, putative 0.0222 0.0911 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0081 0.0186
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0228 0.2499
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0014 0.0125
Onchocerca volvulus 0.0047 0.013 0.0292
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0292 0.603
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0087 0.0309 0.0308
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0053 0.0121
Mycobacterium ulcerans arylsulfatase AtsB 0.0018 0.0004 0.0034
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0003 0.0004
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0101 0.0229
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0179 0.1962
Schistosoma mansoni hypothetical protein 0.0265 0.11 0.2546
Plasmodium vivax SET domain protein, putative 0.0126 0.0483 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0109
Schistosoma mansoni alkaline phosphatase 0.0317 0.1334 0.3088
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0101 0.1094
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0027 0.0044 0.0043
Plasmodium falciparum polyubiquitin binding protein, putative 0.0035 0.0079 0.2676
Onchocerca volvulus 0.0027 0.0044 0.0096
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0145 0.0569 0.0568
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0043 0.0406
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0039 0.0098 0.0097
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0101 0.1094
Giardia lamblia Hypothetical protein 0.0018 0.0004 0.0186
Loa Loa (eye worm) glutamate receptor 2 0.0057 0.0177 0.0458
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0053 0.0052
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0145 0.0569 0.0568
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0222 0.0911 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0109
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0196 0.0795 0.0794
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0043 0.0459
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0132
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0014 0.0082
Schistosoma mansoni glutamate receptor NMDA 0.0057 0.0177 0.0408
Echinococcus multilocularis NMDA receptor 0.0087 0.0309 0.0308
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0109
Echinococcus multilocularis alkaline phosphatase 0.0317 0.1334 0.1333
Echinococcus multilocularis tumor protein p63 0.0363 0.1537 0.1536
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0483 0.1117
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0007
Schistosoma mansoni glutamate receptor kainate 0.0057 0.0177 0.0408
Onchocerca volvulus 0.0478 0.2048 0.4703
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0042 0.0109 0.2251
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0107 0.04 0.0399
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0132
Echinococcus multilocularis bloom syndrome protein 0.0066 0.0218 0.0217
Echinococcus granulosus glutamate NMDA receptor subunit 0.0057 0.0177 0.0176
Echinococcus multilocularis tyrosine kinase 0.0027 0.0044 0.0043
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0072 0.0244 0.0632
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0228 0.2499
Brugia malayi phosphofructokinase 0.0222 0.0911 0.2389
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.0024 0.0023
Loa Loa (eye worm) RecQ helicase 0.0066 0.0218 0.0566
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.028
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0265 0.11 0.1099
Brugia malayi intermediate filament protein 0.0135 0.0522 0.1369
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0021 0.0014 0.0081
Entamoeba histolytica hypothetical protein 0.0023 0.0024 0.024
Schistosoma mansoni cpg binding protein 0.0031 0.0061 0.014
Loa Loa (eye worm) hypothetical protein 0.0047 0.0132 0.034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0228 0.2499
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0101 0.1094
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0109 0.0287
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0042 0.0109 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Brugia malayi Cathepsin L-like precursor 0.0018 0.0003 0.0007
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0024 0.0029 0.0077
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0081 0.0883
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0003 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0126 0.0483 0.1117
Entamoeba histolytica hypothetical protein 0.0039 0.0094 0.1007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.013 0.034
Loa Loa (eye worm) hypothetical protein 0.0478 0.2048 0.5365
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0101 0.1094
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0109 0.0287
Leishmania major cathepsin L-like protease 0.0018 0.0003 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0176 0.0405
Schistosoma mansoni regulator of G protein signaling 0.0057 0.0176 0.0405
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0072 0.0686
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0053 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0176 0.0402
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0003 0.0004
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.044 0.2799
Mycobacterium tuberculosis Probable reductase 0.0116 0.044 0.2799
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0051 0.0151 0.039
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0053 0.0052
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0149 0.0384
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.0105
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0012 0.0119
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0013 0.0012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0053 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0101 0.1094
Chlamydia trachomatis endonuclease IV 0.0083 0.0292 0.1853
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0042 0.0109 0.2251
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0121 0.046 0.0459
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0222 0.0911 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0081 0.008
Brugia malayi CXXC zinc finger family protein 0.003 0.0054 0.0141
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0083 0.0292 0.3052
Leishmania major cathepsin L-like protease 0.0069 0.0228 0.2208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0053 0.0132
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0101 0.1094
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0145 0.0569 0.0568
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0027 0.0044 0.0109
Loa Loa (eye worm) hypothetical protein 0.0063 0.0201 0.052
Schistosoma mansoni 6-phosphofructokinase 0.0222 0.0911 0.2109
Loa Loa (eye worm) hypothetical protein 0.0039 0.0098 0.0249
Loa Loa (eye worm) glutamate receptor 0.0162 0.0642 0.1678
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0189 0.0433
Mycobacterium ulcerans hypothetical protein 0.0022 0.0019 0.018
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.024 0.0239
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0066 0.052
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0081 0.0866
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0053 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0003 0.0004
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0149 0.3076
Brugia malayi glutathione reductase 0.0051 0.0149 0.0391
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Schistosoma mansoni hypothetical protein 0.0165 0.0656 0.1517
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0087 0.0309 0.0308
Brugia malayi Metabotropic glutamate receptor precursor. 0.0162 0.0642 0.1683
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0081 0.0185
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.037 0.157 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.024 0.263
Loa Loa (eye worm) hypothetical protein 0.0132 0.0511 0.1334
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0075 0.019
Echinococcus multilocularis dna polymerase kappa 0.004 0.0101 0.01
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0145 0.0569 0.0568
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0179 0.0386
Mycobacterium ulcerans arylsulfatase AtsD 0.0018 0.0004 0.0034
Onchocerca volvulus 0.0042 0.0109 0.0246
Schistosoma mansoni coup transcription factor 0.0029 0.0053 0.0121
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0189 0.0433
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0005
Brugia malayi hypothetical protein 0.0018 0.0004 0.0012
Echinococcus multilocularis neutral amino acid transporter A 0.037 0.157 0.1569
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0024 0.0028 0.0061
Entamoeba histolytica hypothetical protein 0.0057 0.0176 0.1904
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0081 0.008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0053 0.0139
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.0939 0.0938
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0013 0.0012
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0018 0.0004 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0008
Loa Loa (eye worm) 6-phosphofructokinase 0.0222 0.0911 0.2384
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0179 0.1733
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0053 0.0052
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0085 0.0299 0.0298
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0053 0.0139
Echinococcus multilocularis Regulator of G protein signaling 20 0.0057 0.0176 0.0175
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0106 0.0106
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0057 0.0176 0.0175
Brugia malayi polk-prov protein 0.003 0.0057 0.015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0094 0.0093

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.4 nM Displacement of [3H]flumazenil from GABAA/BzR complex in bovine cerebral cortex membrane ChEMBL. 18325771

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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