Detailed information for compound 517141

Basic information

Technical information
  • TDR Targets ID: 517141
  • Name: (2S)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyace tyl]amino]-N-[(2S)-5-(diaminomethylideneamino )-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-3-me thylbutanamide
  • MW: 509.021 | Formula: C22H29ClN6O4S
  • H donors: 5 H acceptors: 5 LogP: 2.28 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC(=N)NCCC[C@@H](C(=O)c1nccs1)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](c1cccc(c1)Cl)O
  • InChi: 1S/C22H29ClN6O4S/c1-12(2)16(29-20(33)17(30)13-5-3-6-14(23)11-13)19(32)28-15(7-4-8-27-22(24)25)18(31)21-26-9-10-34-21/h3,5-6,9-12,15-17,30H,4,7-8H2,1-2H3,(H,28,32)(H,29,33)(H4,24,25,27)/t15-,16-,17+/m0/s1
  • InChiKey: MVCIZAJAEQZGMJ-YESZJQIVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxy-acetyl]amino]-N-[(1S)-4-guanidino-1-(thiazole-2-carbonyl)butyl]-3-methyl-butanamide
  • (2S)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxy-1-oxoethyl]amino]-N-[(1S)-4-guanidino-1-[oxo(2-thiazolyl)methyl]butyl]-3-methylbutanamide
  • (2S)-N-[(2S)-5-[bis(azanyl)methylideneamino]-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxy-ethanoyl]amino]-3-methyl-butanamide
  • (2S)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxy-acetyl]amino]-N-[(1S)-4-guanidino-1-(thiazole-2-carbonyl)butyl]-3-methyl-butyramide
  • (2S)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxy-1-oxoethyl]amino]-N-[(1S)-4-guanidino-1-[oxo-(2-thiazolyl)methyl]butyl]-3-methylbutanamide
  • (2S)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxy-ethanoyl]amino]-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-3-methyl-butanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor XI Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii PAN domain-containing protein Get druggable targets OG5_134971 All targets in OG5_134971
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
Toxoplasma gondii PAN domain-containing protein Get druggable targets OG5_134971 All targets in OG5_134971
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0125
Trypanosoma cruzi rho-like GTP binding protein, putative 0.0012 0.0039 0.0145
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0915 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0091 0.015
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.5727
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0068 0.0473 0.078
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0021 0.0114 0.0513
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0091 0.0091
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0011 0.0019
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0068 0.0473 0.5115
Treponema pallidum phosphoribosylpyrophosphate synthetase 0.0021 0.0114 0.0633
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0366 0.0603
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0915 0.4447
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0068 0.0473 0.2276
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0382 0.183
Treponema pallidum NADH oxidase 0.0019 0.0092 0.0377
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0915 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0025 0.0236
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0008 0.0011 0.0019
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0048 0.0188
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0142 0.105 0.5111
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0092 0.0405
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0048 0.0188
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0915 0.4447
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0091 0.015
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0074 0.0362
Loa Loa (eye worm) glutathione reductase 0.0054 0.0366 0.0366
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0056 0.0382 0.063
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.0865 0.1426
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.0865 0.9411
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1727 0.2848
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0091 0.04
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0008 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0125
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Schistosoma mansoni sensor histidine kinase/response regulator 0.0015 0.006 0.0098
Schistosoma mansoni survival motor neuron protein 0.0047 0.031 0.0511
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0124 0.0915 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0098
Loa Loa (eye worm) small GTPase 0.0012 0.0039 0.0039
Plasmodium vivax glutathione reductase, putative 0.0054 0.0366 0.3425
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0382 0.183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.0865 0.9411
Plasmodium falciparum thioredoxin reductase 0.0054 0.0366 0.5475
Loa Loa (eye worm) GTP-binding protein 0.0135 0.0996 0.0996
Mycobacterium tuberculosis Probable reductase 0.0123 0.0903 0.8877
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0382 0.063
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0074 0.0122
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0056 0.0382 0.063
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0068 0.0473 0.2274
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0059 0.0404 0.1455
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0125 0.0125
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0142 0.105 0.384
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.0382 0.063
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0366 0.3425
Brugia malayi PXA domain containing protein 0.0019 0.0091 0.0091
Leishmania major ATP-dependent phosphofructokinase 0.0124 0.0915 0.4449
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0091 0.015
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0091 0.0091
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0041 0.0068
Brugia malayi PAN domain containing protein 0.0023 0.0125 0.0125
Echinococcus multilocularis microtubule associated protein 2 0.0786 0.6065 1
Mycobacterium leprae PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) 0.0021 0.0114 0.057
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0021 0.0114 0.0188
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.0382 0.5727
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0915 0.0915
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0092 0.1268
Echinococcus multilocularis ras C3 botulinum toxin substrate 2 0.0012 0.0039 0.0064
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0366 0.0603
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0211 0.0349
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0075
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0011 0.0019
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0041 0.0068
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0011 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0382 0.1831
Loa Loa (eye worm) hypothetical protein 0.0019 0.0091 0.0091
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0504 0.4681
Brugia malayi Adenine phosphoribosyltransferase 0.0021 0.0114 0.0114
Trichomonas vaginalis rho4, putative 0.0012 0.0039 0.0145
Toxoplasma gondii hypothetical protein 0.0023 0.0125 0.0427
Entamoeba histolytica Rho family GTPase 0.0012 0.0039 0.0326
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0092 0.0661 0.3198
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0125 0.0427
Wolbachia endosymbiont of Brugia malayi amidophosphoribosyltransferase 0.0021 0.0114 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0091 0.0091
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0092 0.217
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0073 0.0235
Brugia malayi Protein kinase domain containing protein 0.0016 0.0074 0.0074
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0091 0.04
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0382 0.063
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0118 0.0865 0.8477
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0059 0.0404 0.1455
Onchocerca volvulus 0.0023 0.0125 0.0611
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0136 0.0136
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0011 0.0019
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0123 0.0903 0.8877
Echinococcus granulosus ras C3 botulinum toxin substrate 2 0.0012 0.0039 0.0064
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0056 0.0382 0.0382
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0068 0.0473 0.2274
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.1831
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.007 0.0493 0.4565
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0091 0.015
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0092 0.0152
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0211 0.0349
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0142 0.105 0.1732
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Entamoeba histolytica Rho family GTPase 0.0012 0.0039 0.0326
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0208 0.0734
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0041
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0091 0.0091
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.027 0.2046 1
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0661 0.3196
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0092 0.0305
Brugia malayi Uncoordinated protein 44 0.0016 0.0074 0.0074
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0304 0.0501
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0208 0.0734
Mycobacterium ulcerans 6-phosphofructokinase 0.0124 0.0915 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0123 0.0903 0.8877
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0092 0.0661 0.1089
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0091 0.0091
Giardia lamblia Hypothetical protein 0.0056 0.0382 0.5727
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0142 0.105 0.105
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0142 0.105 0.1732
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.0382 0.063
Loa Loa (eye worm) hypothetical protein 0.0019 0.0091 0.0091
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0021 0.0114 0.0513
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0092 0.0405
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.183
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0091 0.015
Loa Loa (eye worm) hypothetical protein 0.0056 0.0382 0.0382
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.3583
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0142 0.105 0.384
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0091 0.015
Entamoeba histolytica Rho family GTPase 0.0012 0.0039 0.0326
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0366 0.1751
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0142 0.105 0.5111
Echinococcus multilocularis Ankyrin 0.0017 0.0075 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0382 0.183
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0021 0.0114 0.0513
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0021 0.0114 0.0513
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0915 0.1509
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0091 0.04
Schistosoma mansoni rac gtpase 0.0012 0.0039 0.0064
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.5727
Toxoplasma gondii thioredoxin reductase 0.0054 0.0366 0.1315
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0092 0.0377
Brugia malayi Pre-SET motif family protein 0.0034 0.0211 0.0211
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Trichomonas vaginalis receptor histidine kinase, putative 0.0015 0.006 0.0247
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.0915 0.0915
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0118 0.0865 0.1426
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0048 0.0188
Brugia malayi PAN domain containing protein 0.0023 0.0125 0.0125
Brugia malayi glutathione reductase 0.0054 0.0366 0.0366
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0025 0.0236
Plasmodium falciparum thioredoxin reductase 0.0019 0.0092 0.1268
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0008 0.0011 0.0019
Trichomonas vaginalis Ribose-phosphate pyrophosphokinase, putative 0.0021 0.0114 0.0512
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0661 0.6256
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0011 0.0019
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0008 0.0009 0.0009
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.1831
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0091 0.015
Entamoeba histolytica Rho family GTPase 0.0012 0.0039 0.0326
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0136 0.0621
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0091 0.015
Schistosoma mansoni cell polarity protein 0.0135 0.0996 0.1643
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0142 0.105 0.5111
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0091 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0382 0.183
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0382 0.1831
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0091 0.015
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0366 0.0366
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0092 0.0661 0.1089
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0068 0.0473 0.078
Mycobacterium ulcerans bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 0.0021 0.0114 0.0633
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0056 0.0382 0.063
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0661 0.3198
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0092 0.0661 0.1089
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0211 0.0745
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0091 0.04
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0092 0.0661 0.3198
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Echinococcus multilocularis ras gtpase 0.0135 0.0996 0.1643
Schistosoma mansoni netrin receptor unc5 0.0016 0.0074 0.0122
Onchocerca volvulus Adenine phosphoribosyltransferase homolog 0.0021 0.0114 0.0556
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0068 0.0473 0.2276
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.0915 1
Echinococcus multilocularis expressed protein 0.0361 0.2757 0.4546
Loa Loa (eye worm) hypothetical protein 0.0056 0.0382 0.0382
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Onchocerca volvulus Putative eukaryotic translation initiation factor 4e 0.0008 0.0009 0.0046
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0011 0.001
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.0021 0.0114 0.1003
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0125 0.0125
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0092 0.0152
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0011 0.0019
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0092 0.0661 0.0661
Brugia malayi PAN domain containing protein 0.0023 0.0125 0.0125
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0208 0.3056
Mycobacterium ulcerans amidophosphoribosyltransferase 0.0021 0.0114 0.0633
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0025 0.0041
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0092 0.0305
Brugia malayi Ras-related protein Rac1 0.0012 0.0039 0.0039
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0092 0.0661 0.3198
Schistosoma mansoni DNA helicase recq5 0.001 0.0025 0.0041
Plasmodium vivax SET domain protein, putative 0.0034 0.0211 0.194
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.183
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0113 0.1589
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0137 0.101 1
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0041 0.0068
Brugia malayi hypothetical protein 0.0019 0.0091 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0211 0.0349
Brugia malayi phosphofructokinase 0.0124 0.0915 0.0915
Mycobacterium ulcerans orotate phosphoribosyltransferase 0.0021 0.0114 0.0633
Onchocerca volvulus 0.0023 0.0125 0.0611
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0025 0.0041
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0068 0.0473 0.171
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0021 0.0114 0.0513
Toxoplasma gondii microneme protein MIC4 0.0023 0.0125 0.0427
Loa Loa (eye worm) adenine phosphoribosyltransferase 0.0021 0.0114 0.0114
Echinococcus granulosus adenine phosphoribosyltransferase 0.0021 0.0114 0.0188
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0008 0.0009 0.0016
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0091 0.0091
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0092 0.0793
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0021 0.0114 0.0513
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0048 0.0188
Plasmodium falciparum glutathione reductase 0.0054 0.0366 0.5475
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0025 0.0057
Loa Loa (eye worm) hypothetical protein 0.0056 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.1236 0.9564 0.9564
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0274 0.0274
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0056 0.0382 0.063
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0025 0.0041
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Echinococcus multilocularis 6 phosphofructokinase 0.0124 0.0915 0.1509
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0092 0.5962
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0092 0.034
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0208 0.0977
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0208 0.3056
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0114 0.057
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0382 0.063
Loa Loa (eye worm) RecQ helicase 0.0024 0.0136 0.0136
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0382 0.1831
Mycobacterium tuberculosis Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase) 0.0021 0.0114 0.057
Brugia malayi PAN domain containing protein 0.0023 0.0125 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0382 0.1831
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0211 0.0349
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0091 0.015
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0011 0.0019
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0274 0.0274
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.183
Echinococcus granulosus death domain containing protein 0.0016 0.0074 0.0122
Trichomonas vaginalis rho5 protein, putative 0.0012 0.0039 0.0145
Onchocerca volvulus 0.0023 0.0125 0.0611
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0021 0.0114 0.0114
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0092 0.0152
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0661 0.3198
Treponema pallidum hypothetical protein 0.0021 0.0114 0.0633
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0053 0.0053
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0304 0.0501
Onchocerca volvulus 0.0092 0.0661 0.3226
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0091 0.0091
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0124 0.0915 0.9007
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.183
Entamoeba histolytica Rho family GTPase 0.0012 0.0039 0.0326
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.0865 0.9411
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0125
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.007 0.0493 0.4565
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0382 0.063
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0068 0.0473 0.5115
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0231
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0208 1
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0015 0.006 0.0247
Toxoplasma gondii PAN domain-containing protein 0.0356 0.2719 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0091 0.04
Brugia malayi Cyclic-nucleotide gated cation channel 0.0008 0.0011 0.0011
Brugia malayi Pre-SET motif family protein 0.0237 0.1792 0.1792
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0091 0.015
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0118 0.0865 0.4202
Brugia malayi orotate phosphoribosyltransferase family protein 0.0021 0.0114 0.0114
Onchocerca volvulus 0.0023 0.0125 0.0611
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0053 0.0053
Leishmania major adenine phosphoribosyltransferase 0.0021 0.0114 0.0513
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0125
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0056 0.0382 0.063
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0208 0.0977
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0015 0.006 0.0247
Giardia lamblia Guanine phosphoribosyltransferase 0.0092 0.0661 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0208 0.0977
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.027 0.2046 1
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0068 0.0473 0.2276
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0092 0.0405
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0382 0.063
Toxoplasma gondii microneme protein, putative 0.0023 0.0125 0.0427
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.0382 0.063
Brugia malayi hypothetical protein 0.0019 0.0091 0.0091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Giardia lamblia Rac/Rho-like protein 0.0012 0.0039 0.0454
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0229 0.1727 0.1727
Brugia malayi PAN domain containing protein 0.0023 0.0125 0.0125
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0091 0.015
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0091 0.015
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0137 0.101 1
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0092 0.0405
Brugia malayi follicle stimulating hormone receptor 0.0269 0.2039 0.2039
Mycobacterium tuberculosis Probable pyrimidine operon regulatory protein PyrR 0.0021 0.0114 0.057
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0125 0.0427
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0091 0.0091
Onchocerca volvulus 0.0012 0.0039 0.019
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0208 0.1912
Toxoplasma gondii subtilisin SUB12 0.0023 0.0125 0.0427
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0504 0.4681
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0008 0.0011 0.0019
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0211 0.0349
Loa Loa (eye worm) hypothetical protein 0.1292 1 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0092 0.0405
Leishmania major hypothetical protein, conserved 0.0056 0.0382 0.1831
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0091 0.015
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0382 0.5727
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Loa Loa (eye worm) rac GTPase 0.0012 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0047 0.031 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0091 0.04
Mycobacterium tuberculosis Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase) 0.0021 0.0114 0.057
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0056 0.0382 0.063
Trichomonas vaginalis rho4, putative 0.0012 0.0039 0.0145
Trichomonas vaginalis sensor histidine kinase, putative 0.0015 0.006 0.0247
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0074 0.0122
Echinococcus granulosus nuclear factor of activated T cells 5 0.0084 0.06 0.0989
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.183
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Brugia malayi hypothetical protein 0.0229 0.1727 0.1727
Trypanosoma brucei trypanothione reductase 0.0054 0.0366 0.1751
Onchocerca volvulus 0.0023 0.0125 0.0611
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0056 0.0382 0.5727
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0208 0.3056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0092 0.0405
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0092 0.0405
Entamoeba histolytica hypothetical protein 0.0019 0.0091 0.0901
Mycobacterium tuberculosis Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) 0.0021 0.0114 0.057
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0142 0.105 0.1732
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0495 0.2385
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0125 0.0427
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0092 0.0405
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0091 0.015
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0011 0.0019
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0025 0.0057
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0274 0.0451
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0092 0.0405
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0915 0.4449
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0068 0.0473 0.078
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.0382 0.3583
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0075 0.0124
Echinococcus granulosus microtubule associated protein 2 0.0786 0.6065 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0096 0.0158
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0091 0.015
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0025 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0208 0.0977
Trichomonas vaginalis GTPase_rho, putative 0.0012 0.0039 0.0145
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0382 0.1831
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0074 0.0122
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.183
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.0382 0.0382
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0125 0.0125
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0091 0.015
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.183
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0011 0.0019
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.0382 0.063
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0021 0.0114 0.0513
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0382 0.1831
Giardia lamblia Adenine phosphoribosyltransferase 0.0021 0.0114 0.1603
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0021 0.0114 0.0188
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0041 0.0068
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0091 0.015
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0092 0.0793
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0068 0.0473 0.2274
Echinococcus granulosus expressed protein 0.0361 0.2757 0.4546
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0092 0.0405
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0025 0.0025
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.0382 0.063
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0015 0.006 0.0247
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Brugia malayi PAN domain containing protein 0.0023 0.0125 0.0125
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0008 0.0009 0.0009
Mycobacterium tuberculosis Conserved protein 0.0021 0.0114 0.057
Brugia malayi 6-phosphofructokinase 0.0124 0.0915 0.0915
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0008 0.0009 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Entamoeba histolytica Rho family GTPase 0.0012 0.0039 0.0326
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0208 0.0734
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.031 0.031
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0091 0.0091
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0092 0.0405
Schistosoma mansoni DNA helicase recq1 0.001 0.0025 0.0041
Onchocerca volvulus 0.0023 0.0125 0.0611
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Brugia malayi small GTPase 0.0012 0.0039 0.0039
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0142 0.105 0.1732
Leishmania major xanthine phosphoribosyltransferase 0.0092 0.0661 0.3198
Trypanosoma cruzi rho-like GTP binding protein, putative 0.0012 0.0039 0.0145
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0021 0.0114 0.0188
Schistosoma mansoni uracil phosphoribosyltransferase 0.0021 0.0114 0.0188
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0092 0.1268
Brugia malayi GTP-binding protein 0.0135 0.0996 0.0996
Echinococcus granulosus ras gtpase 0.0135 0.0996 0.1643
Loa Loa (eye worm) hypothetical protein 0.0034 0.0211 0.0211
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0382 0.183
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0202 0.0332
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0048 0.0423
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0915 0.4447
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0118 0.0865 0.1426
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0382 0.0382
Brugia malayi PAN domain containing protein 0.0023 0.0125 0.0125
Trichomonas vaginalis sensor histidine kinase, putative 0.0015 0.006 0.0247
Brugia malayi PAN domain containing protein 0.0023 0.0125 0.0125
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0092 0.0092
Toxoplasma gondii hypothetical protein 0.0023 0.0125 0.0427
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0092 0.0405
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0011 0.0019
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0382 0.063
Trichomonas vaginalis ribose-phosphate pyrophosphokinase, putative 0.0021 0.0114 0.0512
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0025
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0661 0.3198
Brugia malayi PAN domain containing protein 0.0023 0.0125 0.0125
Brugia malayi Death domain containing protein 0.0016 0.0074 0.0074
Mycobacterium ulcerans adenine phosphoribosyltransferase 0.0021 0.0114 0.0633
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0092 0.0405
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0092 0.0405
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0091 0.015
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.183
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0091 0.015
Plasmodium falciparum glutathione reductase 0.0019 0.0092 0.1268
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.183
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0208 0.1738
Onchocerca volvulus 0.0023 0.0125 0.0611
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0075 0.0626
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0142 0.105 0.1732
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0091 0.0091
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0125 0.0427
Trichomonas vaginalis set domain proteins, putative 0.027 0.2047 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0091 0.0091
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0092 0.0661 0.1089
Leishmania major hypothetical protein, conserved 0.0056 0.0382 0.1831
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0011 0.001
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0092 0.0661 0.1089
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.0915 0.4449
Echinococcus granulosus Ankyrin 0.0017 0.0075 0.0124
Echinococcus multilocularis adenine phosphoribosyltransferase 0.0021 0.0114 0.0188
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0382 0.1831
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.3583
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0382 0.5727
Leishmania major eukaryotic translation initiation factor-like 0.0068 0.0473 0.2276
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0366 0.3223
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0382 0.1831
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0091 0.015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0092 0.0405
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0008 0.0009 0.0009
Brugia malayi 6-phosphofructokinase 0.0124 0.0915 0.0915
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0021 0.0114 0.0513
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0208 1
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0091 0.015
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0252 0.1192
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0208 0.2196
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0021 0.0114 0.0188
Schistosoma mansoni gtpase_rho 0.0012 0.0039 0.0064
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0123 0.0903 0.8877
Toxoplasma gondii microneme protein MIC17A 0.0023 0.0125 0.0427
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0041 0.0041
Schistosoma mansoni microtubule-associated protein tau 0.0786 0.6065 1
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.0865 0.1426
Echinococcus granulosus 6 phosphofructokinase 0.0124 0.0915 0.1509
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0661 0.3198
Toxoplasma gondii aldehyde dehydrogenase 0.0118 0.0865 0.3157
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0269 0.2039 0.2039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0211 0.0349
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0056 0.0382 0.063
Onchocerca volvulus 0.0023 0.0125 0.0611
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0091 0.015
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.183
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0382 0.1831
Treponema pallidum adenine phosphoribosyltransferase 0.0021 0.0114 0.0633
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0092 0.0661 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0137 0.101 1
Mycobacterium ulcerans hypothetical protein 0.0021 0.0114 0.0633
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0023 0.0125 0.0427
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0125
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.0382 0.1831
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0382 0.183
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0137 0.101 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0074
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0074 0.0122
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0092 0.5962
Loa Loa (eye worm) translation initiation factor 4E 0.0068 0.0473 0.0473
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.0382 0.0382
Mycobacterium tuberculosis Conserved hypothetical protein 0.0072 0.0504 0.4681
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0056 0.0382 0.063
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0091 0.015
Echinococcus granulosus bloom syndrome protein 0.0024 0.0136 0.0224
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0382 0.063
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0084 0.06 0.0989
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0091 0.015
Toxoplasma gondii orotate phosphoribosyltransferase 0.0021 0.0114 0.0385
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0068 0.0473 0.2276
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0091 0.015
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0382 0.063
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0025 0.0041
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0382 0.1831
Onchocerca volvulus 0.0023 0.0125 0.0611
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.1792 0.1792
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0091 0.015
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.183
Toxoplasma gondii PAN/Apple domain-containing protein 0.0023 0.0125 0.0427
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1727 0.2848
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0123 0.0903 0.8877
Brugia malayi GTP-binding protein, identical 0.0135 0.0996 0.0996
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0092 0.0661 0.7022
Loa Loa (eye worm) PDE1B protein 0.0142 0.105 0.105
Echinococcus multilocularis Ras C3 botulinum toxin substrate 1 0.0012 0.0039 0.0064
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0092 0.0661 0.2403
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.0915 0.1509
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0382 0.1831
Brugia malayi PXA domain containing protein 0.0019 0.0091 0.0091
Mycobacterium tuberculosis Conserved hypothetical protein 0.0072 0.0504 0.4681
Onchocerca volvulus 0.0047 0.031 0.1513
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.0382 0.5727
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0091 0.015
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0211 0.0349
Toxoplasma gondii microneme protein MIC17B 0.0023 0.0125 0.0427
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0021 0.0114 0.0188
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0136 0.0224
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0208 0.0977
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0123 0.0903 0.8877
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0274 0.0451
Loa Loa (eye worm) hypothetical protein 0.0019 0.0091 0.0091
Brugia malayi translation initiation factor 4E 0.0068 0.0473 0.0473
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0092 0.0405
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0124 0.0915 0.9007
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0382 0.1831
Mycobacterium leprae AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE) 0.0021 0.0114 0.057
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0125 0.0125
Plasmodium falciparum orotate phosphoribosyltransferase 0.0021 0.0114 0.1603
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0092 0.0405
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0041 0.0068
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0092 0.0661 0.1089
Leishmania major eukaryotic translation initiation factor-like protein 0.0068 0.0473 0.2276
Onchocerca volvulus 0.027 0.2048 1
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0041 0.0068
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.0915 0.4447
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0011 0.0019
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0092 0.1268
Giardia lamblia hypothetical protein 0.0056 0.0382 0.5727
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0136 0.0621
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0091 0.0091
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0021 0.0114 0.0513
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0208 0.1912
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0125
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0008 0.0011 0.0019
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.183
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0382 0.0382
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0011 0.0011
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0382 0.063
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0252 0.1192
Toxoplasma gondii PAN domain-containing protein 0.0356 0.2719 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0092 0.0377
Brugia malayi PAN domain containing protein 0.0023 0.0125 0.0125
Onchocerca volvulus 0.0023 0.0125 0.0611
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0074 0.0074
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0021 0.0114 0.0188
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0208 0.0977
Wolbachia endosymbiont of Brugia malayi orotate phosphoribosyltransferase 0.0021 0.0114 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0091 0.0091
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0091 0.015
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0091 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0382 0.1831
Leishmania major cAMP-specific phosphodiesterase, putative 0.027 0.2046 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0091 0.04
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0091 0.015
Loa Loa (eye worm) hypothetical protein 0.0023 0.0125 0.0125
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0382 0.183
Toxoplasma gondii microneme protein MIC17C 0.0023 0.0125 0.0427
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0021 0.0114 0.0513
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0091 0.0091
Entamoeba histolytica hypothetical protein 0.0019 0.0091 0.0901
Onchocerca volvulus 0.0034 0.0211 0.1032
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0382 0.183
Leishmania major trypanothione reductase 0.0054 0.0366 0.1751
Brugia malayi Thioredoxin reductase 0.0054 0.0366 0.0366
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0015 0.006 0.0247
Mycobacterium tuberculosis Conserved protein 0.0021 0.0114 0.057
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0142 0.105 0.5111
Entamoeba histolytica hypothetical protein 0.0019 0.0091 0.0901
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0011 0.0011
Loa Loa (eye worm) phosphofructokinase 0.0124 0.0915 0.0915
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0068 0.0473 0.2274
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0092 0.0405
Schistosoma mansoni cell polarity protein 0.0135 0.0996 0.1643
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0142 0.105 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0074 0.0122
Trichomonas vaginalis receptor histidine kinase, putative 0.0015 0.006 0.0247
Onchocerca volvulus 0.0023 0.0125 0.0611
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0382 0.1376
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0208 0.0977
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0091 0.015
Echinococcus granulosus uridine 5' monophosphate synthase 0.0021 0.0114 0.0188
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0092 0.0377
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0092 0.0405
Loa Loa (eye worm) hypothetical protein 0.0008 0.0011 0.0011
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0123 0.0903 0.8877
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0092 0.0661 0.3198
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0125 0.0125

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 116 nM Binding affinity to human factor 11a assessed as release of p-nitroaniline after 10 to 120 mins by spectrophotometric analysis ChEMBL. 24405333
IC50 (binding) = 120 nM Inhibition of human factor 11a ChEMBL. 18053726
IC50 (binding) = 120 nM Inhibition of human factor 11a ChEMBL. 18053726
IC50 (binding) = 0.116 uM Inhibition of F11a ChEMBL. 16524727
IC50 (binding) = 0.116 uM Inhibition of F11a ChEMBL. 16524727

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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