Detailed information for compound 517942

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 365.859 | Formula: C20H20ClN5
  • H donors: 2 H acceptors: 2 LogP: 3.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)Nc1nccc(n1)c1cccc(c1)N1CCNCC1
  • InChi: 1S/C20H20ClN5/c21-16-4-2-5-17(14-16)24-20-23-8-7-19(25-20)15-3-1-6-18(13-15)26-11-9-22-10-12-26/h1-8,13-14,22H,9-12H2,(H,23,24,25)
  • InChiKey: UGXVRWRXHWTSCU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcium/calmodulin-dependent protein kinase II delta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major glucose transporter/membrane transporter D2, putative 0.001 0.0024 0.0179
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0292 0.2032 1
Schistosoma mansoni steroid dehydrogenase 0.0008 0.001 0.001
Echinococcus granulosus Sugar transporter ERD6 protein 0.001 0.0024 0.0014
Echinococcus granulosus solute carrier family 22 0.001 0.0024 0.0014
Trypanosoma brucei glucose transporter, putative 0.001 0.0024 0.0187
Loa Loa (eye worm) hypothetical protein 0.0027 0.0147 0.046
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0134 0.1663
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Toxoplasma gondii transporter, major facilitator family protein 0.001 0.0024 0.0203
Plasmodium vivax sugar transporter, putative 0.001 0.0024 0.0364
Brugia malayi intermediate filament protein 0.0027 0.0147 0.046
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0403 0.5708
Giardia lamblia Hexose transporter 0.001 0.0024 0.0033
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0121 0.1428
Schistosoma mansoni carbonyl reductase 0.0008 0.001 0.001
Plasmodium falciparum calcium-dependent protein kinase 1 0.0019 0.0092 0.4233
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0024 0.0014
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0019 0.0092 0.1195
Brugia malayi hypothetical protein 0.0016 0.007 0.0203
Brugia malayi POT family protein 0.0082 0.0538 0.1773
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0292 0.2032 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0143 0.0448
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0029
Trypanosoma cruzi hexose transporter 0.001 0.0024 0.0187
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.001 0.0024 0.0069
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0134 0.6401
Schistosoma mansoni DNA helicase recq5 0.0009 0.0019 0.0019
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0104 0.0698 0.9205
Schistosoma mansoni cpg binding protein 0.003 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0018 0.0079 0.0234
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0024 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0021 0.0145
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0019 0.0009
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0019 0.0092 0.0082
Schistosoma mansoni steroid dehydrogenase 0.0008 0.001 0.001
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0147 0.046
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0052
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0204 0.2822
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.001 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0757 0.1796
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0698 0.9205
Echinococcus multilocularis solute carrier family 22 0.001 0.0024 0.0014
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0121 0.055
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0024 0.0014
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0403 0.1942
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Echinococcus multilocularis solute carrier family 22 0.001 0.0024 0.0014
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0019 0.0092 0.0276
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0045 0.0465
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0204 0.0463
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.001 0.0019
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0121 0.1617
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0403 0.1942
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0204 0.0481
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.001 0.0024 0.0024
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0019 0.0092 0.11
Brugia malayi 6-phosphofructokinase 0.0113 0.0757 0.251
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0171 0.0402
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0092 0.4244
Schistosoma mansoni transcription factor btf3 0.0035 0.0204 0.0204
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0134 0.1663
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0024 0.0047
Echinococcus multilocularis transcription factor btf3 0.0035 0.0204 0.0194
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0019 0.0009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0019 0.013
Brugia malayi hypothetical protein 0.001 0.0024 0.0047
Echinococcus granulosus solute carrier family 22 0.001 0.0024 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.042 0.042
Entamoeba histolytica hypothetical protein 0.0024 0.0121 0.0265
Schistosoma mansoni DNA helicase recq1 0.0009 0.0019 0.0019
Schistosoma mansoni glucose transport protein 0.001 0.0024 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4209 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0024 0.0187
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0757 0.1557
Schistosoma mansoni carbonyl reductase 0.0008 0.001 0.001
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.001 0.0019
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0171 1
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0757 0.1796
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0034 0.0083
Echinococcus granulosus bloom syndrome protein 0.0022 0.0111 0.0102
Echinococcus granulosus Solute carrier family 22 5 0.1041 0.7368 0.7366
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0133 0.0904 0.3001
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0019 0.0092 0.0276
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0038 0.036
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0117 0.0789 0.3852
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0757 0.251
Brugia malayi Sugar transporter family protein 0.001 0.0024 0.0047
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0549 0.1811
Leishmania major protein kinase, putative 0.0019 0.0092 0.1055
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Onchocerca volvulus 0.001 0.0024 0.0041
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0019 0.003
Schistosoma mansoni steroid dehydrogenase 0.0008 0.001 0.001
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0019 0.0009
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Loa Loa (eye worm) POT family protein 0.0082 0.0538 0.1773
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.001 0.0019
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0171 0.4202
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0757 1
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.000000000063849
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0204 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0403 0.0393
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.001 0.0019
Echinococcus granulosus cpg binding protein 0.0032 0.0178 0.0168
Trypanosoma brucei glucose transporter, putative 0.001 0.0024 0.0187
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0757 0.1796
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0757 0.1781
Brugia malayi hypothetical protein 0.0025 0.0134 0.0417
Onchocerca volvulus 0.0062 0.0393 0.1127
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0147 0.046
Onchocerca volvulus 0.001 0.0024 0.0041
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0549 0.054
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0019 0.0092 0.2147
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0024 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4209 1
Onchocerca volvulus 0.001 0.0024 0.0041
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0134 0.1806
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0121 0.055
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0698 0.9205
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0171 0.0383
Leishmania major hypothetical protein, conserved 0.001 0.0024 0.0179
Trypanosoma cruzi sugar transporter, putative 0.001 0.0024 0.0187
Echinococcus multilocularis mitogen activated protein kinase 0.0104 0.0698 0.0689
Entamoeba histolytica protein kinase, putative 0.0019 0.0092 0.0196
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0038 0.0376
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0124
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Toxoplasma gondii facilitative glucose transporter GT1 0.001 0.0024 0.0203
Trichomonas vaginalis myo-inositol transporter, putative 0.001 0.0024 0.0052
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0757 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0024 0.0014
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0171 1
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0038 0.0067
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0171 0.0402
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0757 0.1796
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0109 0.0732 0.2427
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Schistosoma mansoni cpg binding protein 0.0032 0.0178 0.0178
Giardia lamblia Sugar-proton symporter 0.001 0.0024 0.0033
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0011 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.017 0.1167 0.1167
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0047 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0171 0.0402
Trichomonas vaginalis steroid dehydrogenase, putative 0.0008 0.001 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0698 0.1655
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0117 0.0789 0.078
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0022 0.0013
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Echinococcus multilocularis lamin dm0 0.0027 0.0147 0.0137
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0171 0.0402
Onchocerca volvulus 0.001 0.0024 0.0041
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0045 0.0117
Toxoplasma gondii sugar transporter ST3 0.001 0.0024 0.0203
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Schistosoma mansoni steroid dehydrogenase 0.0008 0.001 0.001
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0111 0.0261
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0393 0.0393
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0111 0.0261
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0019 0.0459
Echinococcus multilocularis cpg binding protein 0.0032 0.0178 0.0168
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0057 0.0159
Brugia malayi Pre-SET motif family protein 0.0426 0.2988 1
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0171 0.2339
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Echinococcus granulosus solute carrier family 22 0.001 0.0024 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0019 0.0092 0.0215
Onchocerca volvulus 0.001 0.0024 0.0041
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0024 0.0047
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Leishmania major basic transcription factor 3a, putative 0.0035 0.0204 0.2493
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Onchocerca volvulus 0.001 0.0024 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4209 1
Onchocerca volvulus 0.0027 0.0147 0.0403
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0171 0.8287
Leishmania major glucose transporter, lmgt1 0.001 0.0024 0.0179
Schistosoma mansoni protein kinase 0.0153 0.1042 0.1042
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0403 0.0403
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0121 0.055
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.001 0.0024 0.0187
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0204 0.0652
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Echinococcus multilocularis Sugar transporter ERD6 protein 0.001 0.0024 0.0014
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0403 0.0393
Plasmodium vivax hexose transporter 0.001 0.0024 0.0364
Echinococcus multilocularis solute carrier family 22 0.001 0.0024 0.0014
Toxoplasma gondii sugar transporter ST1 0.001 0.0024 0.0203
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0022 0.0022
Trypanosoma brucei glucose transporter, putative 0.001 0.0024 0.0187
Trichomonas vaginalis sugar transport protein, putative 0.001 0.0024 0.0052
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.001 0.0024 0.0069
Leishmania major myo-inositol/proton symporter (MIT) 0.001 0.0024 0.0179
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0111 0.0341
Echinococcus granulosus calcium dependent protein kinase 0.0018 0.0083 0.0073
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0121 0.1488
Onchocerca volvulus 0.001 0.0024 0.0041
Echinococcus multilocularis musashi 0.0027 0.0147 0.0137
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Brugia malayi hypothetical protein 0.001 0.0024 0.0047
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0393 0.0383
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0045 0.0117
Trichomonas vaginalis glucose transporter, putative 0.001 0.0024 0.0052
Schistosoma mansoni protein kinase 0.0153 0.1042 0.1042
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0021 0.0145
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0171 0.0402
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0171 0.0402
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.001 0.0024 0.0718
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0171 0.4202
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0121 0.5729
Echinococcus multilocularis calcium dependent protein kinase 0.0018 0.0083 0.0073
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0052
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0134 0.6401
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Trypanosoma brucei sugar transporter, putative 0.001 0.0024 0.0187
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.006 0.1318
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0019 0.003
Brugia malayi Sugar transporter family protein 0.001 0.0024 0.0047
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0045 0.0117
Trypanosoma brucei glucose transporter, putative 0.001 0.0024 0.0187
Trypanosoma brucei glucose transporter, putative 0.001 0.0024 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0052
Schistosoma mansoni retinal dehydrogenase 0.0008 0.001 0.001
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0057 0.0159
Onchocerca volvulus 0.001 0.0024 0.0041
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0019 0.0009
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0757 0.0757
Schistosoma mansoni hypothetical protein 0.001 0.0024 0.0024
Toxoplasma gondii sugar transporter ST2 0.001 0.0024 0.0203
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.001 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0698 0.1655
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0019 0.0092 0.1195
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0204 0.5071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0403 0.1942
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0117 0.0789 0.3852
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0019 0.0092 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0393 0.0393
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0104 0.0698 0.8835
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0019 0.003
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0035 0.0086
Brugia malayi Sugar transporter family protein 0.001 0.0024 0.0047
Brugia malayi beta-NAC-like protein 0.0035 0.0204 0.0652
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0757 0.0748
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0117 0.0789 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0117 0.0789 0.0789
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0393 0.5565
Trypanosoma brucei glucose transporter, putative 0.001 0.0024 0.0187
Entamoeba histolytica hypothetical protein 0.0035 0.0204 0.0463
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0024 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0204 0.0481
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0117 0.0789 0.2615
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0019 0.0092 0.0082
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0019 0.0092 0.1195
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Onchocerca volvulus 0.001 0.0024 0.0041
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0134 0.1663
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0104 0.0698 0.8835
Schistosoma mansoni intermediate filament proteins 0.0027 0.0147 0.0147
Leishmania major glucose transporter, lmgt3 0.001 0.0024 0.0179
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0549 0.054
Brugia malayi MAP kinase sur-1 0.0104 0.0698 0.2311
Trichomonas vaginalis set domain proteins, putative 0.0485 0.3407 0.8094
Treponema pallidum fructose-bisphosphate aldolase 0.0597 0.4209 1
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0171 0.2339
Onchocerca volvulus 0.001 0.0024 0.0041
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0757 0.251
Entamoeba histolytica protein kinase, putative 0.0019 0.0092 0.0196
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0059 0.0715
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0117 0.0789 0.078
Echinococcus multilocularis mitogen activated protein kinase 3 0.0104 0.0698 0.0689
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0393 0.0383
Echinococcus granulosus lamin dm0 0.0027 0.0147 0.0137
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.000000000063849
Schistosoma mansoni lamin 0.0027 0.0147 0.0147
Brugia malayi Cam kinase protein 1 0.0019 0.0092 0.0276
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0024 0.0187
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0019 0.0021
Schistosoma mansoni protein kinase 0.0153 0.1042 0.1042
Onchocerca volvulus 0.001 0.0024 0.0041
Schistosoma mansoni steroid dehydrogenase 0.0008 0.001 0.001
Giardia lamblia Fructose-bisphosphate aldolase 0.0597 0.4209 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0019 0.0092 0.0276
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0038 0.0376
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0035 0.0025
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0019 0.0092 0.0082
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0008 0.001 0.0019
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0121 0.2905
Leishmania major glucose transporter, lmgt2 0.001 0.0024 0.0179
Echinococcus granulosus transcription factor btf3 0.0035 0.0204 0.0194
Plasmodium falciparum calcium-dependent protein kinase 4 0.0019 0.0092 0.4233
Onchocerca volvulus 0.003 0.0166 0.046
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0024 0.0014
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0019 0.0092 0.0082
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0022 0.0013
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0024 0.0014
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0047 0.0037
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0393 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0052
Echinococcus multilocularis geminin 0.017 0.1167 0.1159
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Trypanosoma cruzi hexose transporter, putative 0.001 0.0024 0.0187
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0757 0.3697
Plasmodium falciparum hexose transporter 0.001 0.0024 0.0718
Schistosoma mansoni microtubule-associated protein tau 0.141 1 1
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0008 0.001 0.0019
Echinococcus granulosus mitogen activated protein kinase 3 0.0104 0.0698 0.0689
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0134 0.3246
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0757 0.1781
Schistosoma mansoni sugar transporter 0.001 0.0024 0.0024
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.001 0.001
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0022 0.0013
Schistosoma mansoni glucose transport protein 0.001 0.0024 0.0024
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0133 0.0904 0.3001
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0757 0.3697
Loa Loa (eye worm) sugar transporter 0.001 0.0024 0.0047
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.001 0.0019
Plasmodium falciparum calcium-dependent protein kinase 5 0.0019 0.0092 0.4233
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0204 0.2598
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0549 0.0549
Onchocerca volvulus 0.0084 0.0549 0.1588
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0393 0.0393
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0035 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Brugia malayi hypothetical protein 0.001 0.0024 0.0047
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Schistosoma mansoni sugar transporter 0.001 0.0024 0.0024
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0024 0.0014
Schistosoma mansoni steroid dehydrogenase 0.0008 0.001 0.001
Plasmodium falciparum calcium-dependent protein kinase 3 0.0019 0.0092 0.4233
Onchocerca volvulus 0.001 0.0024 0.0041
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0121 0.055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.000000000063849
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Brugia malayi major facilitator superfamily protein 0.001 0.0024 0.0047
Loa Loa (eye worm) sugar transporter 0.001 0.0024 0.0047
Onchocerca volvulus 0.001 0.0024 0.0041
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0403 0.0403
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0204 0.2598
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0045 0.0465
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0757 0.3697
Schistosoma mansoni steroid dehydrogenase 0.0008 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4209 1
Brugia malayi Cytochrome P450 family protein 0.0013 0.0045 0.0117
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0426 0.2988 1
Plasmodium vivax SET domain protein, putative 0.0062 0.0393 1
Mycobacterium ulcerans integral membrane transport protein 0.001 0.0024 0.0069
Echinococcus granulosus intermediate filament protein 0.0027 0.0147 0.0137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0092 0.0276
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0019 0.0092 0.2147
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4209 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0024 0.0187
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.000000000063849
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Brugia malayi 6-phosphofructokinase 0.0113 0.0757 0.251
Schistosoma mansoni sugar transporter 0.001 0.0024 0.0024
Echinococcus multilocularis microtubule associated protein 2 0.141 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0698 0.1655
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0052
Schistosoma mansoni steroid dehydrogenase 0.0008 0.001 0.001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0035 0.0025
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0045 0.0465
Trichomonas vaginalis glucose transporter, putative 0.001 0.0024 0.0052
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0019 0.013
Loa Loa (eye worm) hypothetical protein 0.0084 0.0549 0.1811
Echinococcus granulosus synaptic vesicle 2 protein 0.001 0.0024 0.0014
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0171 0.8287
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0111 0.0102
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0121 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0166 0.0524
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0019 0.0092 0.0082
Loa Loa (eye worm) hypothetical protein 0.0009 0.0019 0.003
Trichomonas vaginalis glucose transporter, putative 0.001 0.0024 0.0052
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0112
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0153 0.1042 0.1033
Brugia malayi phosphofructokinase 0.0113 0.0757 0.251
Trypanosoma brucei glucose transporter, putative 0.001 0.0024 0.0187
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.000000000063849
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0171 0.0402
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Schistosoma mansoni glucose transporter 0.001 0.0024 0.0024
Trypanosoma brucei protein kinase, putative 0.0104 0.0698 0.9205
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0153 0.1042 0.1033
Onchocerca volvulus 0.001 0.0024 0.0041
Echinococcus multilocularis synaptic vesicle 2 protein 0.001 0.0024 0.0014
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Loa Loa (eye worm) RecQ helicase 0.0022 0.0111 0.0341
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.001 0.0019
Onchocerca volvulus 0.0485 0.3407 1
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.000000000063849
Onchocerca volvulus Putative transporter 0.001 0.0024 0.0041
Echinococcus granulosus solute carrier family 22 0.001 0.0024 0.0014
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Giardia lamblia Kinase, CMGC MAPK 0.0104 0.0698 0.1639
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Onchocerca volvulus 0.001 0.0024 0.0041
Loa Loa (eye worm) hypothetical protein 0.0062 0.0393 0.1286
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0292 0.2032 1
Schistosoma mansoni hypothetical protein 0.017 0.1167 0.1167
Echinococcus multilocularis lamin 0.0027 0.0147 0.0137
Trypanosoma brucei glucose transporter 2A 0.001 0.0024 0.0187
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0757 0.251
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.001 0.0019
Trypanosoma brucei glucose transporter, putative 0.001 0.0024 0.0187
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0403 0.1942
Onchocerca volvulus 0.001 0.0024 0.0041
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0757 0.0748
Trypanosoma brucei glucose transporter 1E 0.001 0.0024 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0393 0.0393
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.001 0.0024 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0052
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.001 0.0024 0.0069
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0117 0.0789 0.3852
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0008 0.001 0.0019
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4209 1
Trypanosoma cruzi hexose transporter, putative 0.001 0.0024 0.0187
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0597 0.4209 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0019 0.0092 0.4233
Schistosoma mansoni steroid dehydrogenase 0.0008 0.001 0.001
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0204 0.2598
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.000000000063849
Onchocerca volvulus 0.0027 0.0147 0.0403
Schistosoma mansoni carbonyl reductase 0.0008 0.001 0.001
Schistosoma mansoni sugar transporter 0.001 0.0024 0.0024
Trypanosoma cruzi glucose transporter, putative 0.001 0.0024 0.0187
Schistosoma mansoni glucose transport protein 0.001 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.001 0.001
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0171 0.0122
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0757 0.9598
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0171 0.0383
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0757 0.1781
Echinococcus granulosus lamin 0.0027 0.0147 0.0137
Trypanosoma cruzi hexose transporter, putative 0.001 0.0024 0.0187
Schistosoma mansoni cpg binding protein 0.0032 0.0178 0.0178
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4209 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.001 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.000000000063849
Schistosoma mansoni steroid dehydrogenase 0.0008 0.001 0.001
Leishmania major hypothetical protein, conserved 0.0009 0.0021 0.0139
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0597 0.4209 1
Echinococcus granulosus mitogen activated protein kinase 0.0104 0.0698 0.0689
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0024 0.0052
Leishmania major cytochrome p450-like protein 0.0013 0.0045 0.0446
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0024 0.0014
Trypanosoma cruzi hexose transporter, putative 0.001 0.0024 0.0187
Brugia malayi major facilitator superfamily protein 0.001 0.0024 0.0047
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0019 0.0092 0.2147
Brugia malayi Cytochrome P450 family protein 0.0013 0.0045 0.0117
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0403 0.5043
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0147 0.046
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0698 0.1655
Brugia malayi Pre-SET motif family protein 0.0062 0.0393 0.1286
Echinococcus multilocularis solute carrier family 22 0.001 0.0024 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0204 0.0481
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0092 0.0092
Plasmodium vivax calcium-dependent protein kinase, putative 0.0019 0.0092 0.2147
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0171 0.2339
Loa Loa (eye worm) hypothetical protein 0.0025 0.0134 0.0417
Leishmania major hypothetical protein, conserved 0.0025 0.0134 0.1596
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0047
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0104 0.0698 0.2311
Brugia malayi CXXC zinc finger family protein 0.003 0.0166 0.0524
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Schistosoma mansoni lamin 0.0027 0.0147 0.0147
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0045 0.0172
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0372 0.5262
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.001 0.0024 0.0014
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0372 0.0363
Mycobacterium ulcerans sugar transporter 0.001 0.0024 0.0069
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.001 0.0024 0.1253
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0121 0.1617
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0104 0.0698 0.9205
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0757 0.0757
Echinococcus granulosus geminin 0.017 0.1167 0.1159
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0104 0.0698 0.9205
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0698 0.0698
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0022 0.0013
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0104 0.0698 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0035 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4209 1
Trichomonas vaginalis sugar transporter, putative 0.001 0.0024 0.0052

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.009 uM Inhibition of cloned CaMK2delta (unknown origin) ChEMBL. 18334293
IC50 (binding) = 0.009 uM Inhibition of cloned CaMK2delta (unknown origin) ChEMBL. 18334293
IC50 (binding) = 0.32 uM Inhibition of CaMK2delta-mediated vimentin phosphorylation in human HL2 cells after 1 hr by ELISA ChEMBL. 18334293
IC50 (binding) = 0.32 uM Inhibition of CaMK2delta-mediated vimentin phosphorylation in human HL2 cells after 1 hr by ELISA ChEMBL. 18334293

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.