Detailed information for compound 539960

Basic information

Technical information
  • TDR Targets ID: 539960
  • Name: (2R,3R,4S,5R)-2,3,5,6-tetrahydroxy-4-[(2R,3R, 5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetr ahydropyran-2-yl]oxy-hexanal
  • MW: 342.296 | Formula: C12H22O11
  • H donors: 8 H acceptors: 9 LogP: -5.02 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]([C@@H]([C@@H]([C@H](C=O)O)O)O[C@@H]1O[C@H](CO)[C@@H](C([C@H]1O)O)O)O
  • InChi: 1S/C12H22O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8-,9?,10+,11-,12+/m0/s1
  • InChiKey: DKXNBNKWCZZMJT-WLWMBPAKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R,3R,4S,5R)-2,3,5,6-tetrahydroxy-4-[[(2R,3R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]hexanal
  • (2R,3R,4S,5R)-2,3,5,6-tetrahydroxy-4-[(2R,3R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hexanal
  • (2R,3R,4S,5R)-2,3,5,6-tetrahydroxy-4-[(2R,3R,5R,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-hexanal
  • (2R,3R,4S,5R)-2,3,5,6-tetrahydroxy-4-[(2R,3R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanal
  • 4-O-alpha-D-galactopyranosyl-D-galactose
  • 13117-26-5
  • D-Galactose, 4-O-alpha-D-galactopyranosyl-
  • Digal
  • Gal alpha 1-4 gal beta
  • Gal-1-4-gal
  • Galabiose
  • Galactosyl-alpha1-4-galactose
  • alpha-D-Galactopyranose-(1-4)-beta-D-galactopyranose

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH2 domain-containing protein 0.0389 0.2499 0.2496
Leishmania major solanesyl-diphosphate synthase, putative 0.0667 0.4405 0.4403
Leishmania major cysteine peptidase A (CPA) 0.0037 0.0083 0.0079
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0572 0.0401
Echinococcus granulosus histone acetyltransferase KAT2B 0.0159 0.0919 0.0919
Onchocerca volvulus 0.0108 0.0572 0.897
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Entamoeba histolytica cysteine protease, putative 0.0037 0.0083 0.0007
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0062 0.0257 0.0253
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0083 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0454 0.0454
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0056 0.0215 0.0215
Trypanosoma brucei protein kinase, putative 0.0052 0.0186 0.0182
Toxoplasma gondii hypothetical protein 0.0053 0.0194 0.019
Toxoplasma gondii hypothetical protein 0.0027 0.0013 0.0009
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Brugia malayi intermediate filament protein 0.0116 0.0628 0.0624
Loa Loa (eye worm) hypothetical protein 0.0114 0.0613 0.061
Echinococcus granulosus tar DNA binding protein 0.0063 0.026 0.026
Echinococcus granulosus zinc finger protein 0.0026 0.0005 0.0005
Schistosoma mansoni smad 0.0027 0.0011 0.0011
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0498 0.3247 0.3247
Leishmania major farnesyl pyrophosphate synthase 0.1482 1 1
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0667 0.4405 0.4403
Loa Loa (eye worm) hypothetical protein 0.021 0.1273 0.1269
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0667 0.4405 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.1273 0.1269
Leishmania major cathepsin L-like protease 0.0141 0.0795 0.0791
Echinococcus multilocularis zinc finger protein 0.0026 0.0005 0.0005
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0083 0.0083
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0083 0.0079
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0177 0.0173
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0186 0.0186
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0037 0.0083 0.0079
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0361 0.0357
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0454 0.0454
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1482 1 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0166 0.0968 0.0968
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0572 0.0401
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0013 0.0009
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.09 0.0896
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0177 0.0173
Loa Loa (eye worm) acetyltransferase 0.0166 0.0968 0.0965
Echinococcus multilocularis smad 0.0027 0.0011 0.0011
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0147 0.0143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Onchocerca volvulus 0.0108 0.0572 0.897
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0186 0.0182
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0361 0.0361
Loa Loa (eye worm) transcription factor SMAD2 0.0389 0.2499 0.2496
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0056 0.0215 0.0215
Mycobacterium tuberculosis Conserved protein 0.0108 0.0572 0.0401
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0104 0.0544 0.0541
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0129 0.0711 0.0708
Loa Loa (eye worm) ctsf protein 0.0037 0.0083 0.0079
Echinococcus multilocularis microtubule associated protein 2 0.1412 0.9516 0.9516
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0083 0.0079
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0498 0.3247 0.3125
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0286 0.0286
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0572 0.0401
Brugia malayi MH2 domain containing protein 0.0027 0.0011 0.0007
Brugia malayi RNA binding protein 0.0063 0.026 0.0256
Toxoplasma gondii cathepsin CPL 0.0037 0.0083 0.0079
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0754 0.5002 0.5
Schistosoma mansoni smad1 5 8 and 0.0027 0.0011 0.0011
Loa Loa (eye worm) cysteine protease 0.0037 0.0083 0.0079
Onchocerca volvulus 0.0116 0.0628 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0309 0.0309
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0667 0.4405 0.4403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0572 0.0568
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0361 0.0699
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.026 0.0256
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0083 0.0083
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0101 0.0101
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0667 0.4405 0.4405
Echinococcus granulosus Smad4 0.0027 0.0011 0.0011
Brugia malayi MH2 domain containing protein 0.0027 0.0011 0.0007
Schistosoma mansoni microtubule-associated protein tau 0.1412 0.9516 0.9516
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0186 0.0186
Echinococcus granulosus cathepsin l1 0.0037 0.0083 0.0083
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0572 0.0493
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0078 0.0364 0.0361
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0112 0.0596 0.0592
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1482 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0177 0.0177
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0217 0.0213
Loa Loa (eye worm) intermediate filament protein 0.0116 0.0628 0.0624
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0104
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Echinococcus granulosus smad 0.0027 0.0011 0.0011
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0498 0.3247 1
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Brugia malayi MH1 domain containing protein 0.0027 0.0011 0.0007
Mycobacterium ulcerans hypothetical protein 0.0108 0.0572 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0037 0.0083 0.0079
Loa Loa (eye worm) RNA binding protein 0.0063 0.026 0.0256
Loa Loa (eye worm) hypothetical protein 0.0051 0.018 0.0176
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0498 0.3247 0.7136
Schistosoma mansoni intermediate filament proteins 0.0116 0.0628 0.0628
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0178 0.0377
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0572 0.0493
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1482 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.0795 0.0791
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0083 0.0083
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0572 0.0218
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0177 0.0173
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.2091 0.2088
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.09 0.0896
Trypanosoma cruzi polyprenyl synthase, putative 0.0754 0.5002 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.026 0.0256
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0572 0.0572
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.0795 0.0791
Brugia malayi beta-lactamase 0.0108 0.0572 0.0568
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.2091 0.2088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0186 0.0182
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0147 0.0143
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0454 0.045
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0498 0.3247 0.3247
Echinococcus multilocularis tar DNA binding protein 0.0063 0.026 0.026
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0572 0.0568
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.0795 0.0791
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0083 0.0083
Echinococcus multilocularis cysteine protease 0.0037 0.0083 0.0083
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0186 0.0182
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0132 0.012
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0667 0.4405 0.4405
Giardia lamblia Farnesyl diphosphate synthase 0.1482 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.008 0.008
Brugia malayi Bromodomain containing protein 0.0087 0.0424 0.042
Mycobacterium ulcerans beta-lactamase 0.0108 0.0572 0.0218
Brugia malayi acetyltransferase, GNAT family protein 0.0166 0.0968 0.0965
Brugia malayi beta-lactamase family protein 0.0108 0.0572 0.0568
Brugia malayi Polyprenyl synthetase family protein 0.0667 0.4405 0.4403
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase) 0.0169 0.0988 0.0824
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0011 0.0011
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0754 0.5002 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0037 0.0083 0.0083
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0454 0.0454
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0011 0.0011
Mycobacterium ulcerans hypothetical protein 0.0174 0.1021 0.0684
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1482 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Loa Loa (eye worm) hypothetical protein 0.0054 0.02 0.0196
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0083 0.0007
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0754 0.5002 0.5002
Schistosoma mansoni hypothetical protein 0.0067 0.0286 0.0286
Echinococcus granulosus intermediate filament protein 0.0116 0.0628 0.0628
Trypanosoma brucei mitochondrial DNA polymerase beta 0.033 0.2091 0.2088
Loa Loa (eye worm) hypothetical protein 0.0144 0.0816 0.0813
Brugia malayi hypothetical protein 0.0036 0.008 0.0076
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0572 0.0568
Loa Loa (eye worm) hypothetical protein 0.0042 0.012 0.0116
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0186 0.0182
Plasmodium vivax vivapain-2 0.0037 0.0083 0.0079
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0498 0.3247 0.3125
Loa Loa (eye worm) Smad1 0.0027 0.0011 0.0007
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0147 0.0143
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0572 0.0568
Loa Loa (eye worm) hypothetical protein 0.0056 0.0215 0.0211
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1482 1 1
Loa Loa (eye worm) polyprenyl synthetase 0.0667 0.4405 0.4403
Trypanosoma cruzi cruzipain precursor, putative 0.0141 0.0795 0.0791
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0572 0.0572
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0667 0.4405 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0037 0.0083 0.0079
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0286 0.0282
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0083 0.0083
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0112 0.0596 0.0596
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0667 0.4405 0.4196
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0186 0.0182
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0286 0.0286
Mycobacterium ulcerans lipase LipD 0.0108 0.0572 0.0218
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0186 0.0055
Schistosoma mansoni Smad4 0.0027 0.0011 0.0011
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1482 1 1
Brugia malayi Smad1 0.0027 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0177 0.0095
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0186 0.0186
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0186 0.0182
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0011 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0104
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0178 0.0178
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0454 0.0454
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0037 0.0083 0.0079
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0361 0.0361
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0186 0.0182
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0572 0.0218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0691 0.4573 0.4475
Toxoplasma gondii ABC1 family protein 0.0108 0.0572 0.0568
Echinococcus multilocularis lamin 0.0116 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0067 0.0286 0.0282
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0572 0.0568
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1482 1 1
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0667 0.4405 0.4403
Loa Loa (eye worm) hypothetical protein 0.0049 0.0165 0.0161
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0036 0.008 0.008
Brugia malayi cytoplasmic intermediate filament protein 0.0062 0.0257 0.0253
Echinococcus granulosus cathepsin l cysteine peptidase 0.0037 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0144 0.0816 0.0816
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0572 0.0572
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0112 0.0596 0.0425
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0361 0.0357
Brugia malayi Intermediate filament tail domain containing protein 0.0116 0.0628 0.0624
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0286 0.0282
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0454 0.045
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.1273 0.1269
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1482 1 1
Brugia malayi MH1 domain containing protein 0.0027 0.0011 0.0007
Loa Loa (eye worm) fibroinase 0.0037 0.0083 0.0079
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1482 1 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0186 0.0182
Schistosoma mansoni hypothetical protein 0.0067 0.0286 0.0286
Brugia malayi PHD-finger family protein 0.0031 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.0054 0.02 0.0196
Mycobacterium leprae Probable lipase LipE 0.0108 0.0572 0.1273
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0498 0.3247 0.3125
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0572 0.0493
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0101 0.0101
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Schistosoma mansoni zinc finger protein 0.0026 0.0005 0.0005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0116 0.0628 0.0624
Echinococcus multilocularis musashi 0.0116 0.0628 0.0628
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0572 0.1273
Trypanosoma cruzi polyprenyl synthase, putative 0.0754 0.5002 0.5
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0177 0.0095
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0011 0.0011
Echinococcus multilocularis lamin dm0 0.0116 0.0628 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1482 1 1
Leishmania major cathepsin L-like protease 0.0141 0.0795 0.0791
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0286 0.0286
Loa Loa (eye worm) TAR-binding protein 0.0063 0.026 0.0256
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0572 0.0493
Echinococcus granulosus GPCR family 2 0.0067 0.0286 0.0286
Onchocerca volvulus 0.0108 0.0572 0.897
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0286 0.0282
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0309 0.0309
Schistosoma mansoni hypothetical protein 0.0067 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0754 0.5002 0.5002
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1482 1 1
Schistosoma mansoni bromodomain containing protein 0.0074 0.0336 0.0336
Brugia malayi MH2 domain containing protein 0.0389 0.2499 0.2496
Schistosoma mansoni smad1 5 8 and 0.0027 0.0011 0.0011
Trypanosoma cruzi major cysteine proteinase, putative 0.0111 0.0588 0.0585
Echinococcus multilocularis Smad4 0.0027 0.0011 0.0011
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0178 0.0178
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1482 1 1
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1482 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Schistosoma mansoni smad1 5 8 and 0.0027 0.0011 0.0011
Schistosoma mansoni lamin 0.0116 0.0628 0.0628
Plasmodium vivax vivapain-2 0.0037 0.0083 0.0079
Schistosoma mansoni glutathione synthetase 0.0498 0.3247 0.3247
Brugia malayi beta-lactamase family protein 0.0108 0.0572 0.0568
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Brugia malayi Probable ClpP-like protease 0.0078 0.0361 0.0357
Leishmania major cathepsin L-like protease 0.0141 0.0795 0.0791
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.0624
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1482 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0112 0.0596 0.0243
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0132 0.0128
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0357
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0572 0.0572
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0083 0.0007
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0013 0.0009
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0186 0.0182
Brugia malayi Bromodomain containing protein 0.0046 0.0147 0.0143
Brugia malayi MAP kinase sur-1 0.0052 0.0186 0.0182
Echinococcus granulosus lamin 0.0116 0.0628 0.0628
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0112 0.0596 0.0592
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0112 0.0596 0.0596
Brugia malayi latrophilin 2 splice variant baaae 0.0144 0.0816 0.0813
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0667 0.4405 1
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0667 0.4405 0.4403
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0083 0.0079
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0498 0.3247 0.7323
Leishmania major polyprenyl synthase, putative 0.0754 0.5002 0.5
Loa Loa (eye worm) beta-lactamase 0.0108 0.0572 0.0568
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0011 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0011 0.0007
Leishmania major mitochondrial DNA polymerase beta 0.033 0.2091 0.2088
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0572 0.0401
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Loa Loa (eye worm) polyprenyl synthetase 0.1482 1 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0361 0.0361
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0667 0.4405 0.4403
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0147 0.0143
Leishmania major hypothetical protein, conserved 0.0108 0.0572 0.0568
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.1273 0.1269
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0361 0.0357
Schistosoma mansoni trans-prenyltransferase 0.0667 0.4405 0.4405
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0454 0.0454
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0361 0.0357
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1482 1 1
Trichomonas vaginalis esterase, putative 0.0108 0.0572 0.0493
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0166 0.0968 0.0968
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0112 0.0596 0.0596
Echinococcus multilocularis cysteine protease 0.0037 0.0083 0.0083
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0667 0.4405 0.4403
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0079
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0572 0.0401
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0667 0.4405 0.4403
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0498 0.3247 0.2994
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0754 0.5002 0.5002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0572 0.0401
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0112 0.0596 0.0243
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.1021 0.0858
Treponema pallidum octaprenyl-diphosphate synthase 0.0754 0.5002 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0104
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0104
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0572 0.0568
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0156 0.09 0.0896
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Echinococcus granulosus microtubule associated protein 2 0.1412 0.9516 0.9516
Schistosoma mansoni lamin 0.0116 0.0628 0.0628
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0572 0.0493
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0186 0.0186
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0572 0.0401
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0361 0.0794
Mycobacterium tuberculosis Conserved protein 0.0108 0.0572 0.0401
Onchocerca volvulus 0.0116 0.0628 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.008 0.008
Echinococcus granulosus lamin dm0 0.0116 0.0628 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Echinococcus multilocularis GPCR, family 2 0.0067 0.0286 0.0286
Schistosoma mansoni hypothetical protein 0.0067 0.0286 0.0286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0454 0.0454
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0667 0.4405 1
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0186 0.0186
Mycobacterium tuberculosis Conserved protein 0.0108 0.0572 0.0401
Brugia malayi TAR-binding protein 0.0063 0.026 0.0256
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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