Detailed information for compound 546523

Basic information

Technical information
  • TDR Targets ID: 546523
  • Name: [(7S)-7-acetamido-1,3-dimethoxy-10-methylsulf anyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-2- yl] 2-chloroacetate
  • MW: 477.958 | Formula: C23H24ClNO6S
  • H donors: 1 H acceptors: 3 LogP: 2.9 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCC(=O)Oc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)SC
  • InChi: 1S/C23H24ClNO6S/c1-12(26)25-16-7-5-13-9-18(29-2)22(31-20(28)11-24)23(30-3)21(13)14-6-8-19(32-4)17(27)10-15(14)16/h6,8-10,16H,5,7,11H2,1-4H3,(H,25,26)/t16-/m0/s1
  • InChiKey: WEFSQURXCINXNO-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloroacetic acid [(7S)-7-acetamido-1,3-dimethoxy-10-(methylthio)-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-2-yl] ester
  • [(7S)-7-acetamido-1,3-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-2-yl] 2-chloroethanoate
  • 2-chloroacetic acid [(7S)-7-acetamido-9-keto-1,3-dimethoxy-10-(methylthio)-6,7-dihydro-5H-benzo[a]heptalen-2-yl] ester
  • 2-chloroacetyl-2-demethylthiocolchicine
  • [(7S)-7-acetamido-1,3-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-2-yl] 2-chloroacetate
  • 2-chloroacetic acid [(7S)-7-acetamido-1,3-dimethoxy-10-(methylthio)-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-2-yl] ester
  • 2-chloroacetic acid [(7S)-7-acetamido-9-keto-1,3-dimethoxy-10-(methylthio)-6,7-dihydro-5H-benzo[d]heptalen-2-yl] ester
  • [(7S)-7-acetamido-1,3-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-2-yl] 2-chloroethanoate
  • 148731-67-3
  • (S)-7-(Acetylamino)-5,6,7,9-tetrahydro-1,3-dimethoxy-10-(methylthio)-9-oxobenzo(a)heptalen-2-yl chloroacetate
  • 2-Catc
  • Acetic acid, chloro-, 7-(acetylamino)-5,6,7,9-tetrahydro-1,3-dimethoxy-10-(methylthio)-9-oxobenzo(a)heptalen-2-yl ester, (S)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0473 0.1342
Trichomonas vaginalis helicase, putative 0.0027 0.0058 0.0128
Schistosoma mansoni sterol O-acyltransferase 1 0.0169 0.0788 0.0788
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0058 0.0128
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0439 0.1152
Loa Loa (eye worm) glutathione reductase 0.0193 0.0909 0.0899
Brugia malayi hypothetical protein 0.0235 0.1125 0.1115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0067 0.0263 0.2803
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0088 0.0372 0.1049
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0182 0.0855 0.0845
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.044 0.2176 0.7005
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0411 0.0401
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0411 0.0401
Schistosoma mansoni hypothetical protein 0.1266 0.6418 0.6418
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0473 0.1244
Mycobacterium ulcerans hypothetical protein 0.062 0.3102 1
Echinococcus multilocularis mitogen activated protein kinase 0.0101 0.0439 0.0428
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.002 0.0107
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0016 0.0065
Schistosoma mansoni disulfide oxidoreductase 0.0018 0.0011 0.0011
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0169 0.0788 0.0779
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0218 0.0207
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0411 0.0411
Mycobacterium ulcerans DNA polymerase IV 0.002 0.002 0.0031
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0052 0.0188 0.0178
Schistosoma mansoni lipoxygenase 0.0021 0.0026 0.0026
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0067 0.0263 0.2318
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0473 0.1244
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0034 0.0023
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.1125 0.1115
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0174 0.1821
Brugia malayi MBOAT family protein 0.0169 0.0788 0.0779
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.0526 0.0526
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0058 0.0128
Trypanosoma cruzi glycerol uptake protein, putative 0.0169 0.0788 0.8659
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0182 0.0855 0.0845
Mycobacterium tuberculosis Probable aminotransferase 0.062 0.3102 0.8975
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Leishmania major trypanothione reductase 0.0193 0.0909 1
Onchocerca volvulus 0.0108 0.0473 0.1244
Echinococcus granulosus dna polymerase kappa 0.002 0.002 0.001
Loa Loa (eye worm) hypothetical protein 0.0119 0.0529 0.0518
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0182 0.0855 0.9401
Brugia malayi hypothetical protein 0.0142 0.0649 0.0639
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0067 0.0263 0.2803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0067 0.0263 0.6967
Loa Loa (eye worm) hypothetical protein 0.0096 0.0411 0.0401
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0169 0.0788 0.0779
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.002 0.001
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0528 0.5754
Onchocerca volvulus 0.0119 0.0532 0.1402
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0297 0.0925
Loa Loa (eye worm) hypothetical protein 0.0119 0.0529 0.0518
Leishmania major DNA polymerase eta, putative 0.002 0.002 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0058 0.0128
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0169 0.0788 0.921
Brugia malayi glutathione reductase 0.0193 0.0909 0.0899
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0297 0.0286
Brugia malayi Inositol-1 0.0073 0.0297 0.0286
Schistosoma mansoni sulfide quinone reductase 0.0018 0.0011 0.0011
Mycobacterium ulcerans lipase LipD 0.0108 0.0473 0.1496
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0067 0.0263 0.0263
Trypanosoma cruzi glycerol uptake protein, putative 0.0169 0.0788 0.8659
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0453 0.119
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.002 0.002
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.3365 0.3365
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0081 0.0334 0.3598
Echinococcus granulosus o acyltransferase membrane bound domain 0.0169 0.0788 0.0779
Brugia malayi MBOAT family protein 0.0169 0.0788 0.0779
Loa Loa (eye worm) hypothetical protein 0.0083 0.0344 0.0333
Giardia lamblia DINP protein human, muc B family 0.002 0.002 0.0114
Entamoeba histolytica hypothetical protein 0.0142 0.0649 0.7556
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0416 0.0406
Leishmania major glycerol uptake protein, putative 0.0169 0.0788 0.8659
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0169 0.0788 0.0779
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.002 0.001
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0088 0.0372 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0056 0.0046
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0067 0.0263 0.0252
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0118 0.0526 0.0516
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0026 0.0015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0297 0.3185
Echinococcus granulosus dna polymerase eta 0.002 0.002 0.001
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.1964 1 1
Plasmodium falciparum thioredoxin reductase 0.0067 0.0263 0.2803
Mycobacterium tuberculosis Conserved protein 0.0108 0.0473 0.1342
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0038 0.0113 0.0298
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0174 0.1821
Loa Loa (eye worm) CXXC zinc finger family protein 0.0119 0.0532 0.0522
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0257 0.0798
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.1125 0.1115
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0528 0.5754
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0473 0.5148
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0067 0.0263 0.0731
Loa Loa (eye worm) hypothetical protein 0.0169 0.0788 0.0779
Mycobacterium ulcerans acetylornithine aminotransferase 0.0088 0.0372 0.1169
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0026 0.0172
Mycobacterium ulcerans DNA polymerase IV 0.002 0.002 0.0031
Mycobacterium tuberculosis Conserved protein 0.0108 0.0473 0.1342
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0039 0.0363
Onchocerca volvulus 0.0048 0.0166 0.0417
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0067 0.0263 0.2803
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0473 0.1244
Echinococcus multilocularis RUN 0.0021 0.0026 0.0015
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0026 0.0015
Echinococcus granulosus sterol O acyltransferase 1 0.0169 0.0788 0.0779
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.002 0.001
Brugia malayi beta-lactamase 0.0108 0.0473 0.0463
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0088 0.0372 0.1049
Echinococcus granulosus mitogen activated protein kinase 0.0101 0.0439 0.0428
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0169 0.0788 0.0779
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0016 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0058 0.0128
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0528 0.1391
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0058 0.0128
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0077 0.0066
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0101 0.0439 0.394
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0473 0.1342
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0107
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0107
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0016 0.0005
Echinococcus multilocularis ornithine aminotransferase 0.0088 0.0372 0.0362
Echinococcus multilocularis lamin dm0 0.0027 0.0056 0.0046
Mycobacterium tuberculosis Probable oxidoreductase 0.0489 0.2428 0.7018
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0058 0.0128
Schistosoma mansoni survival motor neuron protein 0.0048 0.0166 0.0166
Toxoplasma gondii hypothetical protein 0.0104 0.0453 0.407
Schistosoma mansoni rab6-interacting 0.0021 0.0026 0.0026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0142 0.0649 0.0639
Echinococcus granulosus mixed lineage leukemia protein mll 0.0033 0.0089 0.0079
Leishmania major hypothetical protein, conserved 0.005 0.0174 0.1821
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0118 0.0526 0.5736
Onchocerca volvulus 0.0083 0.0344 0.0896
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Onchocerca volvulus Huntingtin homolog 0.0119 0.0529 0.1394
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0489 0.2428 0.782
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0052 0.0188 0.0188
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0118 0.0528 0.0528
Giardia lamblia Kinase, CMGC MAPK 0.0101 0.0439 0.5067
Entamoeba histolytica hypothetical protein 0.0142 0.0649 0.7556
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0169 0.0788 0.921
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0077 0.0066
Schistosoma mansoni cpg binding protein 0.0126 0.0567 0.0567
Schistosoma mansoni glutamate synthase 0.0018 0.0011 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0182 0.0855 0.0855
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0067 0.0263 0.0815
Brugia malayi F/Y-rich N-terminus family protein 0.004 0.0124 0.0114
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0025 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0107
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0081 0.0334 0.087
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0088 0.0372 0.0372
Loa Loa (eye worm) histone methyltransferase 0.004 0.0127 0.0116
Loa Loa (eye worm) hypothetical protein 0.0108 0.0473 0.0463
Echinococcus granulosus lamin dm0 0.0027 0.0056 0.0046
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0297 0.3185
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.002 0.0107
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0088 0.0372 0.1169
Onchocerca volvulus 0.0108 0.0473 0.1244
Onchocerca volvulus 0.0169 0.0788 0.2093
Loa Loa (eye worm) hypothetical protein 0.0108 0.0473 0.0463
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0118 0.0528 0.0517
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0033 0.0089 0.0079
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0193 0.0909 0.2608
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0113 0.0276
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0033 0.0089 0.0079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0077 0.0066
Echinococcus multilocularis dnaJ subfamily B 0.1266 0.6418 0.6414
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0118 0.0528 0.5754
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0259 0.0249
Toxoplasma gondii ABC1 family protein 0.0108 0.0473 0.4257
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0088 0.0372 0.1169
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0652 0.3266 0.3259
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0182 0.0855 1
Trichomonas vaginalis set domain proteins, putative 0.0742 0.3726 1
Echinococcus multilocularis zinc finger protein 0.1795 0.9131 0.913
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0528 0.1391
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0039 0.0781
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0081 0.0334 0.087
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0016 0.0061
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0118 0.0528 0.5754
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0067 0.0263 0.2803
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0101 0.0439 0.4764
Schistosoma mansoni hypothetical protein 0.0048 0.0166 0.0166
Echinococcus multilocularis dna polymerase kappa 0.002 0.002 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0181 0.0848 0.0838
Brugia malayi MBOAT family protein 0.0169 0.0788 0.0779
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0039 0.026
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0038 0.0113 0.0298
Trypanosoma brucei unspecified product 0.002 0.002 0.0107
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0344 0.0333
Loa Loa (eye worm) hypothetical protein 0.0066 0.0259 0.0249
Onchocerca volvulus 0.0096 0.0411 0.1078
Brugia malayi hypothetical protein 0.0021 0.0026 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0848 0.0848
Echinococcus multilocularis lamin 0.0027 0.0056 0.0046
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0416 0.0406
Echinococcus granulosus neuropeptide s receptor 0.0944 0.4762 0.4757
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0473 0.1342
Schistosoma mansoni sulfide quinone reductase 0.0018 0.0011 0.0011
Echinococcus multilocularis cpg binding protein 0.0126 0.0567 0.0557
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0016 0.0005
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0067 0.0263 0.0815
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0016 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0107
Mycobacterium tuberculosis Putative ferredoxin reductase 0.044 0.2176 0.6287
Trypanosoma brucei trypanothione reductase 0.0193 0.0909 1
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0169 0.0788 0.0779
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0026 0.0172
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0015
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0016
Echinococcus multilocularis dna polymerase eta 0.002 0.002 0.001
Trypanosoma cruzi trypanothione reductase, putative 0.0193 0.0909 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0182 0.0855 0.2272
Echinococcus multilocularis muscleblind protein 1 0.181 0.9207 0.9206
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0077
Plasmodium vivax SET domain protein, putative 0.0096 0.0411 0.4458
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0107
Plasmodium vivax thioredoxin reductase, putative 0.0193 0.0909 1
Echinococcus granulosus cpg binding protein 0.0126 0.0567 0.0557
Echinococcus multilocularis Aminotransferase class III 0.0088 0.0372 0.0362
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Toxoplasma gondii hypothetical protein 0.0038 0.0113 0.0945
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0528 0.1391
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0297 0.2634
Mycobacterium ulcerans hypothetical protein 0.0108 0.0473 0.1496
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0077 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0411 0.0411
Brugia malayi hypothetical protein 0.0032 0.0084 0.0073
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0473 0.5148
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0182 0.0855 0.0845
Trichomonas vaginalis porcupine, putative 0.0169 0.0788 0.2093
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0039 0.0091
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0528 0.5754
Leishmania major glycerol uptake protein, putative 0.0169 0.0788 0.8659
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.002 0.0028
Echinococcus granulosus muscleblind protein 0.181 0.9207 0.9206
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0016 0.0152
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0052 0.0188 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0107
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0118 0.0526 0.1496
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0473 0.0463
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0118 0.0528 0.1391
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.044 0.2176 0.6287
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.062 0.3102 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0107
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0473 0.1496
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0182 0.0855 0.2272
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.0297 0.7915
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0067 0.0263 0.2803
Echinococcus multilocularis musashi 0.0027 0.0056 0.0046
Toxoplasma gondii hypothetical protein 0.0038 0.0113 0.0945
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0058 0.0128
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0061
Plasmodium vivax ornithine aminotransferase, putative 0.0088 0.0372 0.4024
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0077 0.0066
Toxoplasma gondii histone lysine methyltransferase SET1 0.0229 0.1097 1
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0088 0.0372 0.0362
Echinococcus granulosus thioredoxin glutathione reductase 0.0193 0.0909 0.0899
Loa Loa (eye worm) inositol-1 0.0073 0.0297 0.0286
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.0015
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0088 0.0372 0.1049
Echinococcus multilocularis ubiquitin specific protease 41 0.0182 0.0855 0.0845
Trypanosoma brucei glycerol uptake protein, putative 0.0169 0.0788 0.8659
Leishmania major hypothetical protein, conserved 0.0108 0.0473 0.5148
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0056 0.0046
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.3365 0.3358
Loa Loa (eye worm) hypothetical protein 0.181 0.9207 0.9206
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0089 0.0089
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0016 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0058 0.0128
Schistosoma mansoni DNA polymerase eta 0.002 0.002 0.002
Echinococcus granulosus neuropeptide receptor A26 0.0944 0.4762 0.4757
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0067 0.0263 0.2803
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0107
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.002 0.0026
Entamoeba histolytica hypothetical protein 0.0142 0.0649 0.7556
Echinococcus multilocularis GPCR, family 2 0.0031 0.0077 0.0066
Echinococcus granulosus o acyltransferase membrane bound domain 0.0169 0.0788 0.0779
Toxoplasma gondii GAF domain-containing protein 0.0038 0.0113 0.0945
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0077 0.0066
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0096 0.0411 0.3687
Echinococcus granulosus Aminotransferase class III 0.0088 0.0372 0.0362
Mycobacterium ulcerans L-lysine aminotransferase 0.0088 0.0372 0.1169
Echinococcus granulosus lamin 0.0027 0.0056 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0058 0.0128
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0103
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0489 0.2428 0.7018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.004 0.0127 0.0116
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0026 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0107
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0473 0.0463
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.062 0.3102 0.8975
Echinococcus multilocularis ornithine aminotransferase 0.0088 0.0372 0.0362
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0169 0.0788 0.0779
Loa Loa (eye worm) hypothetical protein 0.181 0.9207 0.9206
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0113 0.0332
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0182 0.0855 0.9401
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1424 0.7228 0.7225
Onchocerca volvulus 0.0021 0.0026 0.0041
Onchocerca volvulus 0.0742 0.3726 1
Plasmodium falciparum ornithine aminotransferase 0.0088 0.0372 0.4024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0067 0.0263 0.2803
Echinococcus granulosus ornithine aminotransferase 0.0088 0.0372 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0058 0.0128
Schistosoma mansoni polycystin 1-related 0.0021 0.0026 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.002 0.0028
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0182 0.0855 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0058 0.0128
Loa Loa (eye worm) hypothetical protein 0.0097 0.0416 0.0406
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0034 0.0023
Mycobacterium leprae Probable lipase LipE 0.0108 0.0473 0.1496
Schistosoma mansoni transcription factor LCR-F1 0.0142 0.0649 0.0649
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.002 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0107
Brugia malayi follicle stimulating hormone receptor 0.1424 0.7228 0.7225
Toxoplasma gondii NADPH-glutathione reductase 0.0067 0.0263 0.2318
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.0526 0.0526
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0107
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0169 0.0788 0.0788
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0113 0.1143
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0788 0.2093
Trypanosoma cruzi glycerol uptake protein, putative 0.0169 0.0788 0.8659
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0473 0.1244
Echinococcus multilocularis muscleblind protein 0.181 0.9207 0.9206
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0113 0.0332
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0052 0.0188 0.0178
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0016 0.007
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0169 0.0788 0.0788
Schistosoma mansoni lipoxygenase 0.0058 0.0218 0.0218
Brugia malayi Pre-SET motif family protein 0.0096 0.0411 0.0401
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0056 0.0046
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0297 0.0286
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0039 0.0091
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0473 0.1496
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0077 0.0066
Schistosoma mansoni lamin 0.0027 0.0056 0.0056
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.002 0.002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0096 0.0411 0.0411
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0067 0.0263 0.2803
Toxoplasma gondii aldehyde dehydrogenase 0.0118 0.0526 0.4744
Schistosoma mansoni intermediate filament proteins 0.0027 0.0056 0.0056
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0473 0.1496
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0182 0.0855 0.0845
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.002 0.0114
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0528 0.1391
Schistosoma mansoni hypothetical protein 0.0142 0.0649 0.0649
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0848 0.0848
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0067 0.0263 0.2803
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0169 0.0788 0.8659
Toxoplasma gondii hypothetical protein 0.0169 0.0788 0.7161
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.0848 0.0838
Brugia malayi MBOAT family protein 0.0169 0.0788 0.0779
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0016 0.0005
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0473 0.1342
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0101 0.0439 0.4764
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0473 0.0463
Trypanosoma brucei glycerol uptake protein, putative 0.0169 0.0788 0.8659
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0113 0.0332
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0052 0.0188 0.0477
Leishmania major glycerol uptake protein, putative 0.0169 0.0788 0.8659
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0067 0.0263 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0058 0.0128
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0101 0.0439 0.4764
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.002 0.0026
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0473 0.1342
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0169 0.0788 0.0788
Entamoeba histolytica hypothetical protein 0.0169 0.0788 0.921
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0067 0.0263 0.2803
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.038 0.037
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.002 0.001
Trypanosoma brucei protein kinase, putative 0.0101 0.0439 0.4764
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0473 0.1342
Mycobacterium tuberculosis Probable reductase 0.044 0.2176 0.6287
Brugia malayi hypothetical protein 0.005 0.0174 0.0164
Loa Loa (eye worm) hhat protein 0.0169 0.0788 0.0779
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0077
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0473 0.5148
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0039 0.026
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0061
Loa Loa (eye worm) hypothetical protein 0.0169 0.0788 0.0779
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0473 0.0473
Loa Loa (eye worm) beta-lactamase 0.0108 0.0473 0.0463
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0049 0.0172 0.0161
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0169 0.0788 0.0779
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0058 0.0128
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Brugia malayi Thioredoxin reductase 0.0193 0.0909 0.0899
Trichomonas vaginalis glutathione reductase, putative 0.0067 0.0263 0.0678
Echinococcus multilocularis neuropeptide receptor A26 0.0944 0.4762 0.4757
Plasmodium falciparum thioredoxin reductase 0.0193 0.0909 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0118 0.0526 0.0516
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0067 0.0263 0.0252
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0067 0.0263 0.0252
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.044 0.2176 0.6287
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0026 0.0015
Leishmania major glycerol uptake protein, putative 0.0169 0.0788 0.8659
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0439 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0058 0.0128
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0067 0.0263 0.6967
Schistosoma mansoni inositol monophosphatase 0.0073 0.0297 0.0297
Brugia malayi intermediate filament protein 0.0027 0.0056 0.0046
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0039 0.0314
Brugia malayi hypothetical protein 0.0021 0.0026 0.0015
Onchocerca volvulus 0.0021 0.0026 0.0041
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0101 0.0439 0.0428
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0182 0.0855 0.9401
Echinococcus granulosus ubiquitin specific protease 41 0.0182 0.0855 0.0845
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0101 0.0439 0.4764
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0049 0.0172 0.0161
Loa Loa (eye worm) hypothetical protein 0.0108 0.0473 0.0463
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0016
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.062 0.3102 0.8319
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0788 0.2093
Loa Loa (eye worm) hypothetical protein 0.0182 0.0855 0.0845
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0039 0.0314
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0174 0.1821
Trichomonas vaginalis mercuric reductase, putative 0.0067 0.0263 0.0678
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0101 0.0439 0.4764
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0039 0.0314
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0174 0.1821
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0067 0.0263 0.2803
Schistosoma mansoni lamin 0.0027 0.0056 0.0056
Onchocerca volvulus Huntingtin homolog 0.0119 0.0529 0.1394
Echinococcus granulosus zinc finger protein 0.1795 0.9131 0.913
Mycobacterium tuberculosis Conserved protein 0.0108 0.0473 0.1342
Loa Loa (eye worm) hypothetical protein 0.0169 0.0788 0.0779
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0169 0.0788 0.0788
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0788 0.2093
Trypanosoma cruzi GUP1, putative 0.0169 0.0788 0.8659
Loa Loa (eye worm) MBOAT family protein 0.0169 0.0788 0.0779
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0473 0.1342
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0439 0.1152
Schistosoma mansoni hypothetical protein 0.0066 0.0259 0.0259
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0067 0.0263 0.0815
Loa Loa (eye worm) hhat protein 0.0169 0.0788 0.0779
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0077
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0026 0.0015
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0174 0.1821
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0169 0.0788 0.921
Loa Loa (eye worm) hypothetical protein 0.0108 0.0473 0.0463
Mycobacterium tuberculosis Probable dehydrogenase 0.044 0.2176 0.6287
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0038 0.0113 0.0332
Loa Loa (eye worm) hypothetical protein 0.0108 0.0473 0.0463
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0473 0.0463
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0101 0.0439 0.4764
Schistosoma mansoni hypothetical protein 0.0021 0.0026 0.0026
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0169 0.0788 0.0788
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0142 0.0649 0.0639
Toxoplasma gondii exonuclease III APE 0.0019 0.0016 0.005
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0016 0.0061
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0067 0.0263 0.2803
Echinococcus granulosus RUN 0.0021 0.0026 0.0015
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0182 0.0855 0.9401
Onchocerca volvulus 0.0027 0.0056 0.0123
Leishmania major hypothetical protein, conserved 0.0169 0.0788 0.8659
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0026 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.044 0.2176 0.6287
Plasmodium falciparum glutathione reductase 0.0067 0.0263 0.2803
Leishmania major glycerol uptake protein, putative 0.0169 0.0788 0.8659
Schistosoma mansoni rab6-interacting 0.0021 0.0026 0.0026
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0344 0.0344
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0297 0.3387
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0169 0.0788 0.0779
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.004 0.0127 0.0116
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0528 0.1391
Schistosoma mansoni zinc finger protein 0.1964 1 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0297 0.077
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Plasmodium vivax glutathione reductase, putative 0.0193 0.0909 1
Treponema pallidum alginate O-acetylation protein (algI) 0.0169 0.0788 1
Loa Loa (eye worm) MBOAT family protein 0.1964 1 1
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0169 0.0788 0.0779
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0016 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.0526 0.1667
Echinococcus granulosus intermediate filament protein 0.0027 0.0056 0.0046
Loa Loa (eye worm) hypothetical protein 0.0169 0.0788 0.0779
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0015
Echinococcus multilocularis neuropeptide s receptor 0.0944 0.4762 0.4757
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0416 0.0406
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0016 0.0061
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0088 0.0372 0.1169
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0067 0.0263 0.2803
Loa Loa (eye worm) hypothetical protein 0.0052 0.0188 0.0178
Schistosoma mansoni inositol monophosphatase 0.0073 0.0297 0.0297
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0052 0.0188 0.0477
Trichomonas vaginalis transmembrane protein nessy, putative 0.0169 0.0788 0.2093
Echinococcus granulosus mitogen activated protein kinase 3 0.0101 0.0439 0.0428
Brugia malayi MAP kinase sur-1 0.0101 0.0439 0.0428
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.0848 0.0838
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0067 0.0263 0.2803
Giardia lamblia NADH oxidase lateral transfer candidate 0.0067 0.0263 0.2982
Entamoeba histolytica vacuolar protein sorting 26 0.0169 0.0788 0.921
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0067 0.0263 0.2803
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0107
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0058 0.0128
Entamoeba histolytica hypothetical protein 0.0142 0.0649 0.7556
Schistosoma mansoni cpg binding protein 0.0119 0.0532 0.0532
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.0015
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0169 0.0788 0.7161
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0174 0.1506
Brugia malayi Hhat protein 0.0169 0.0788 0.0779
Echinococcus multilocularis sterol O acyltransferase 1 0.0169 0.0788 0.0779
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0067 0.0263 0.2803
Brugia malayi diacylglycerol acyltransferase 0.0169 0.0788 0.0779
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0107
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0067 0.0263 0.2803
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.0526 0.1667
Brugia malayi CXXC zinc finger family protein 0.0119 0.0532 0.0522
Echinococcus multilocularis mitogen activated protein kinase 3 0.0101 0.0439 0.0428
Entamoeba histolytica hypothetical protein, conserved 0.0169 0.0788 0.921
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0067 0.0263 0.6967
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0169 0.0788 0.0779
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0088 0.0372 0.1169
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0297 0.3185
Brugia malayi beta-lactamase family protein 0.0108 0.0473 0.0463
Brugia malayi Muscleblind-like protein 0.181 0.9207 0.9206
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0528 0.1391
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.0046
Echinococcus granulosus dnaJ subfamily B 0.1266 0.6418 0.6414
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0066
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0473 0.0473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0848 0.0848
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0169 0.0788 0.0779
Schistosoma mansoni glutamate synthase 0.0018 0.0011 0.0011
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0039 0.0082
Brugia malayi Doublecortin family protein 0.0021 0.0026 0.0015
Onchocerca volvulus 0.0108 0.0473 0.1244
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0088 0.0372 0.3327
Schistosoma mansoni cpg binding protein 0.0126 0.0567 0.0567
Plasmodium falciparum glutathione reductase 0.0193 0.0909 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0344 0.0333
Trypanosoma cruzi GUP1, putative 0.0169 0.0788 0.8659
Leishmania major DNA polymerase kappa, putative 0.002 0.002 0.0107
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0118 0.0528 0.0517
Loa Loa (eye worm) MBOAT family protein 0.0169 0.0788 0.0779
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0107
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0489 0.2428 0.7018
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0088 0.0372 1
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0528 0.1391
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0067 0.0263 0.2803
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0039 0.0091
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0344 0.0333
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0689 0.3455 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0297 0.077
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0182 0.0855 0.0845
Loa Loa (eye worm) hypothetical protein 0.0235 0.1125 0.1115
Toxoplasma gondii thioredoxin reductase 0.0193 0.0909 0.827
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0256 0.1235 0.1235
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0088 0.0372 0.1169
Schistosoma mansoni hypothetical protein 0.0169 0.0788 0.0788
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Onchocerca volvulus 0.0027 0.0056 0.0123
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0058 0.0128
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.0526 0.1667
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0453 0.119
Echinococcus granulosus GPCR family 2 0.0031 0.0077 0.0066
Schistosoma mansoni glutamate synthase 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.005 0.0174 0.0164
Echinococcus granulosus microtubule associated protein 2 0.0671 0.3365 0.3358
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0088 0.0372 0.1169
Brugia malayi beta-lactamase family protein 0.0108 0.0473 0.0463
Loa Loa (eye worm) hypothetical protein 0.0108 0.0473 0.0463
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0169 0.0788 0.8659
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0257 0.0716
Plasmodium falciparum GAF domain-related protein, putative 0.0038 0.0113 0.1143
Schistosoma mansoni hypothetical protein 0.0022 0.0034 0.0034
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0058 0.0128
Schistosoma mansoni loxhd1 0.0021 0.0026 0.0026
Trypanosoma cruzi trypanothione reductase, putative 0.0067 0.0263 0.2803
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0528 0.1391
Brugia malayi hypothetical protein 0.0119 0.0529 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0453 0.119
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0039 0.0314
Echinococcus granulosus o acyltransferase membrane bound domain 0.0169 0.0788 0.0779
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0166 0.0155
Brugia malayi Pre-SET motif family protein 0.0652 0.3266 0.3259
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0528 0.1391
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0101 0.0439 0.4764
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0174 0.1821
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0439 0.1152
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0077
Mycobacterium ulcerans beta-lactamase 0.0108 0.0473 0.1496
Treponema pallidum NADH oxidase 0.0067 0.0263 0.3238
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0088 0.0372 0.1049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0016 0.0061
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0052 0.0188 0.0178
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0439 0.1152
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0107
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0088 0.0372 0.1169
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0473 0.1244
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0118 0.0528 0.1391
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0297 0.3185
Entamoeba histolytica hypothetical protein 0.0023 0.0039 0.0334
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0118 0.0528 0.1391
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0169 0.0788 0.0788
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0052 0.0188 0.0477
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0033 0.0089 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0411 0.0411
Loa Loa (eye worm) thioredoxin reductase 0.0193 0.0909 0.0899
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.0855 0.2272
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.062 0.3102 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0118 0.0528 0.1391
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.002 0.0107
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.0848 0.0838
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.0848 0.0838
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.1964 1 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0218 0.0207
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0182 0.0855 0.0855
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0473 0.5148
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0297 0.077
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0169 0.0788 0.0779
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0169 0.0788 0.0779
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0169 0.0788 0.7161
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0096 0.0411 0.0401
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0181 0.0848 0.0838
Trichomonas vaginalis esterase, putative 0.0108 0.0473 0.1244
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0026 0.0015
Echinococcus multilocularis thioredoxin glutathione reductase 0.0193 0.0909 0.0899
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0067 0.0263 0.2803
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0039 0.0781

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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