Detailed information for compound 549322

Basic information

Technical information
  • TDR Targets ID: 549322
  • Name: 4-[(1E,5E,7E,11R)-11-methoxytetradeca-1,5,7,1 3-tetraenyl]-2-(2-methylcyclopropyl)-4,5-dihy drothiazole
  • MW: 359.569 | Formula: C22H33NOS
  • H donors: 0 H acceptors: 0 LogP: 5.46 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CC[C@@H](CCC=CC=CCC/C=C/C1CSC(=N1)C1CC1C)OC
  • InChi: 1S/C22H33NOS/c1-4-13-20(24-3)15-12-10-8-6-5-7-9-11-14-19-17-25-22(23-19)21-16-18(21)2/h4-6,8,10-11,14,18-21H,1,7,9,12-13,15-17H2,2-3H3/b6-5+,10-8+,14-11+/t18?,19?,20-,21?/m0/s1
  • InChiKey: SSJXRCYFOOLEKV-XWJQJBALSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[(1E,5E,7E,11R)-11-methoxytetradeca-1,5,7,13-tetraenyl]-2-(2-methylcyclopropyl)-4,5-dihydro-1,3-thiazole
  • 4-[(1E,5E,7E,11R)-11-methoxytetradeca-1,5,7,13-tetraenyl]-2-(2-methylcyclopropyl)-2-thiazoline
  • curacin D
  • 164454-36-8

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tubulin subunit beta 0.0278 0.3345 1
Echinococcus granulosus single minded 2 0.0044 0.0315 0.0872
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0215 0.0217
Trypanosoma brucei epsilon tubulin 0.0151 0.1696 0.4855
Treponema pallidum cell division protein FtsZ 0.0065 0.0593 0.7612
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0171 0.0079
Plasmodium vivax tubulin epsilon chain, putative 0.0151 0.1696 0.4931
Entamoeba histolytica hypothetical protein 0.0043 0.0308 0.0506
Trypanosoma cruzi epsilon tubulin, putative 0.0151 0.1696 0.4855
Leishmania major beta tubulin 0.0278 0.3345 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0171 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0593 0.1396
Trypanosoma brucei epsilon tubulin 0.0151 0.1696 0.4855
Trichomonas vaginalis tubulin gamma chain, putative 0.0065 0.0593 0.1396
Echinococcus multilocularis transfer RNA-Lys 0.0044 0.0315 0.029
Leishmania major beta tubulin 0.0278 0.3345 1
Leishmania major alpha tubulin 0.021 0.2468 0.7264
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0026 0.0076
Schistosoma mansoni alpha-glucosidase 0.0139 0.1546 0.458
Leishmania major alpha tubulin 0.021 0.2468 0.7264
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.075 0.2181
Trypanosoma brucei alpha tubulin 0.021 0.2468 0.7264
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.021 0.02
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2468 0.7259
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.021 0.02
Trypanosoma cruzi small ubiquitin protein, putative 0.0031 0.0146 0.002
Echinococcus multilocularis tubulin alpha chain 0.021 0.2468 0.2449
Trypanosoma brucei beta tubulin 0.0278 0.3345 1
Echinococcus granulosus tubulin alpha chain 0.021 0.2468 0.7358
Leishmania major beta tubulin 0.0278 0.3345 1
Trypanosoma cruzi beta tubulin, putative 0.0278 0.3345 1
Brugia malayi hypothetical protein 0.003 0.014 0.0417
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.1837 0.5457
Loa Loa (eye worm) tubulin alpha-3 chain 0.0125 0.1365 0.4034
Trypanosoma brucei alpha tubulin 0.021 0.2468 0.7264
Loa Loa (eye worm) beta-tubulin 0.0278 0.3345 1
Schistosoma mansoni tubulin subunit beta 0.0278 0.3345 1
Echinococcus multilocularis peroxisome assembly protein 26 0.021 0.2468 0.2449
Echinococcus granulosus tubulin delta chain 0.0065 0.0593 0.1708
Echinococcus multilocularis GPCR, family 2 0.0034 0.0192 0.0167
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0555 0.1594
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.014 0.0147
Loa Loa (eye worm) BEN-1 protein 0.0278 0.3345 1
Leishmania major alpha tubulin 0.021 0.2468 0.7264
Trypanosoma cruzi zeta tubulin, putative 0.0065 0.0593 0.1413
Loa Loa (eye worm) hypothetical protein 0.0036 0.0215 0.0572
Echinococcus granulosus tubulin alpha chain 0.021 0.2468 0.7358
Schistosoma mansoni hypothetical protein 0.0034 0.0192 0.05
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.021 0.02
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0308 0.085
Trichomonas vaginalis rotamase, putative 0.0034 0.0181 0.0111
Loa Loa (eye worm) tubulin alpha 2 0.0145 0.1622 0.4807
Echinococcus granulosus Tubulin beta 2C chain 0.0278 0.3345 1
Plasmodium falciparum tubulin delta chain, putative 0.0065 0.0593 0.1539
Echinococcus multilocularis tubulin subunit beta 0.0278 0.3345 0.3328
Loa Loa (eye worm) tubulin alpha 2 0.006 0.0518 0.1484
Trypanosoma brucei glucosidase, putative 0.0036 0.021 0.0219
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0065 0.0593 0.1396
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0555 0.1594
Brugia malayi beta-lactamase 0.0036 0.0215 0.0644
Brugia malayi Tubulin alpha-2 chain 0.021 0.2468 0.7378
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0215 0.0644
Schistosoma mansoni single-minded 0.0059 0.0515 0.1474
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0065 0.0593 0.1539
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0145 0.1622 0.4612
Brugia malayi neuropeptide F receptor 0.0022 0.0026 0.0076
Echinococcus multilocularis Tubulin beta 2C chain 0.0278 0.3345 0.3328
Giardia lamblia Delta tubulin 0.0065 0.0593 0.1396
Echinococcus granulosus expressed protein 0.0034 0.0181 0.047
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.075 1
Echinococcus granulosus geminin 0.0205 0.2393 0.7131
Loa Loa (eye worm) tubulin beta-4 chain 0.0278 0.3345 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0278 0.3345 0.3328
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.075 0.5
Plasmodium vivax tubulin alpha chain, putative 0.021 0.2468 0.7304
Toxoplasma gondii beta tubulin 0.0278 0.3345 1
Schistosoma mansoni hypothetical protein 0.0034 0.0192 0.05
Loa Loa (eye worm) hypothetical protein 0.0182 0.2106 0.6268
Echinococcus granulosus muscleblind protein 0.0145 0.1617 0.4794
Plasmodium falciparum tubulin epsilon chain, putative 0.0151 0.1696 0.4931
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0215 0.0572
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0215 0.0217
Echinococcus multilocularis expressed protein 0.0034 0.0181 0.0156
Echinococcus granulosus Tubulin alpha 1 chain 0.021 0.2468 0.7358
Schistosoma mansoni tubulin subunit delta 0.0065 0.0593 0.1708
Brugia malayi beta-tubulin, identical 0.0278 0.3345 1
Schistosoma mansoni hypothetical protein 0.0043 0.0308 0.085
Entamoeba histolytica tubulin family protein 0.0278 0.3345 1
Brugia malayi Tubulin alpha chain 0.021 0.2468 0.7378
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0404 0.0379
Loa Loa (eye worm) tubulin alpha chain 0.021 0.2468 0.7358
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0145 0.1622 0.4807
Schistosoma mansoni tubulin subunit beta 0.0278 0.3345 1
Brugia malayi beta-lactamase family protein 0.0036 0.0215 0.0644
Onchocerca volvulus 0.0036 0.0215 0.0913
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.021 0.02
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0215 0.019
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0085 0.0849 0.2198
Entamoeba histolytica tubulin alpha chain, putative 0.021 0.2468 0.7259
Brugia malayi Tubulin gamma chain 0.0151 0.1696 0.507
Leishmania major hypothetical protein, conserved 0.0036 0.0215 0.0237
Brugia malayi Tubulin alpha-2 chain 0.021 0.2468 0.7378
Brugia malayi Serotonin receptor 0.0022 0.0026 0.0076
Mycobacterium leprae cell division protein FtsZ 0.0065 0.0593 0.7612
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.075 1
Trypanosoma cruzi tubulin delta chain 0.0065 0.0593 0.1413
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1617 0.1596
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.021 0.0627
Echinococcus granulosus peroxisome assembly protein 26 0.021 0.2468 0.7358
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0555 0.1594
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.091 0.2663
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0192 0.0167
Loa Loa (eye worm) beta-lactamase 0.0036 0.0215 0.0572
Echinococcus granulosus tubulin alpha chain 0.021 0.2468 0.7358
Brugia malayi hypothetical protein 0.0022 0.0026 0.0076
Leishmania major gamma-tubulin 0.0151 0.1696 0.4855
Giardia lamblia Gamma tubulin 0.0151 0.1696 0.4845
Echinococcus multilocularis Tubulin alpha 1 chain 0.021 0.2468 0.2449
Entamoeba histolytica hypothetical protein 0.0043 0.0308 0.0506
Leishmania major beta tubulin 0.0278 0.3345 1
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0026 0.0076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.091 0.0886
Echinococcus granulosus Small ubiquitin modifier 2 0.0031 0.0146 0.0363
Trypanosoma cruzi small ubiquitin protein, putative 0.0031 0.0146 0.002
Loa Loa (eye worm) tubulin gamma chain 0.0151 0.1696 0.5032
Brugia malayi G-protein coupled receptor 0.0022 0.0026 0.0076
Leishmania major small ubiquitin protein, putative 0.0031 0.0146 0.002
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.021 0.02
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0026 0.0076
Trichomonas vaginalis tubulin alpha chain, putative 0.0085 0.0849 0.2198
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.1155 0.3402
Trypanosoma brucei beta tubulin 0.0278 0.3345 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.014 0.0147
Loa Loa (eye worm) tubulin alpha-2 chain 0.021 0.2468 0.7358
Leishmania major beta tubulin 0.0278 0.3345 1
Brugia malayi G protein-coupled receptor 0.0022 0.0026 0.0076
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0192 0.05
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.075 0.2181
Trichomonas vaginalis esterase, putative 0.0036 0.0215 0.0217
Trypanosoma brucei tubulin delta chain 0.0065 0.0593 0.1413
Mycobacterium leprae Probable lipase LipE 0.0036 0.0215 0.188
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.1837 0.5492
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0026 0.0076
Echinococcus multilocularis tubulin epsilon chain 0.0151 0.1696 0.1675
Brugia malayi hypothetical protein 0.0022 0.0026 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.091 0.2663
Loa Loa (eye worm) SMO-1 protein 0.0031 0.0146 0.0363
Plasmodium falciparum tubulin beta chain 0.0278 0.3345 1
Brugia malayi hypothetical protein 0.0022 0.0026 0.0076
Schistosoma mansoni hypothetical protein 0.0034 0.0192 0.05
Brugia malayi Melatonin receptor type 1A 0.0022 0.0026 0.0076
Trypanosoma brucei beta tubulin 0.0151 0.1696 0.4855
Echinococcus multilocularis Tubulin alpha 1 chain 0.021 0.2468 0.2449
Trichomonas vaginalis tubulin, putative 0.0278 0.3345 1
Echinococcus granulosus tubulin subunit TubB 0.021 0.2468 0.7358
Schistosoma mansoni hypothetical protein 0.0205 0.2393 0.7131
Brugia malayi Cell division protein ftsZ 0.0065 0.0593 0.1771
Echinococcus multilocularis Tubulin beta 2C chain 0.0278 0.3345 0.3328
Loa Loa (eye worm) hypothetical protein 0.0125 0.1365 0.4034
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0125 0.1365 0.381
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.1837 0.1816
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0555 0.1594
Echinococcus granulosus tubulin alpha 3 chain 0.021 0.2468 0.7358
Brugia malayi GnHR receptor homolog 0.0022 0.0026 0.0076
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0181 0.047
Trypanosoma brucei zeta tubulin, putative 0.0065 0.0593 0.1413
Loa Loa (eye worm) RNA binding protein 0.0063 0.0555 0.1594
Echinococcus multilocularis tubulin gamma 1 chain 0.0151 0.1696 0.1675
Onchocerca volvulus 0.0085 0.0849 0.3959
Leishmania major alpha tubulin 0.021 0.2468 0.7264
Echinococcus multilocularis tubulin delta chain 0.0065 0.0593 0.0568
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0308 0.0283
Brugia malayi Tubulin beta chain 0.0085 0.0849 0.2539
Echinococcus multilocularis tubulin alpha 3 chain 0.021 0.2468 0.2449
Trichomonas vaginalis tubulin epsilon chain, putative 0.021 0.2468 0.7259
Echinococcus granulosus tubulin alpha chain 0.021 0.2468 0.7358
Echinococcus granulosus tubulin alpha 1C chain 0.021 0.2468 0.7358
Loa Loa (eye worm) BEN-1 protein 0.0278 0.3345 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0026 0.0076
Trypanosoma brucei beta tubulin 0.0278 0.3345 1
Echinococcus multilocularis muscleblind protein 0.0145 0.1617 0.1596
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.091 0.2719
Brugia malayi G-protein coupled receptor 0.0022 0.0026 0.0076
Trypanosoma cruzi tubulin delta chain 0.0065 0.0593 0.1413
Trypanosoma brucei small ubiquitin-related modifier 0.0031 0.0146 0.002
Echinococcus granulosus tubulin epsilon chain 0.0151 0.1696 0.5032
Loa Loa (eye worm) tubulin alpha 2 0.0145 0.1622 0.4807
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.021 0.02
Brugia malayi ORL1-like opioid receptor 0.0022 0.0026 0.0076
Echinococcus granulosus beta tubulin 0.0278 0.3345 1
Schistosoma mansoni tubulin subunit epsilon 0.0151 0.1696 0.5032
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.021 0.0185
Schistosoma mansoni tubulin subunit beta 0.0278 0.3345 1
Schistosoma mansoni tubulin subunit alpha 0.0065 0.0593 0.1708
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1611 0.4775
Trichomonas vaginalis tubulin epsilon chain, putative 0.0278 0.3345 1
Leishmania major beta tubulin 0.0278 0.3345 1
Trypanosoma brucei epsilon tubulin 0.0151 0.1696 0.4855
Echinococcus granulosus tubulin subunit beta 0.0278 0.3345 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.075 0.2022
Brugia malayi Tubulin beta-1 chain 0.0278 0.3345 1
Brugia malayi Ubiquitin-like protein SMT3 0.0031 0.0146 0.0436
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.021 0.02
Schistosoma mansoni alpha tubulin 0.021 0.2468 0.7358
Trichomonas vaginalis tubulin epsilon chain, putative 0.0065 0.0593 0.1396
Leishmania major beta tubulin 0.0278 0.3345 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0151 0.1696 0.4845
Brugia malayi hypothetical protein 0.0022 0.0026 0.0076
Schistosoma mansoni aryl hydrocarbon receptor 0.0172 0.1976 0.5875
Giardia lamblia Beta tubulin 0.0278 0.3345 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.021 0.02
Leishmania major zeta tubulin, putative 0.0065 0.0593 0.1413
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.075 0.2022
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.075 0.2022
Echinococcus multilocularis tubulin alpha 1C chain 0.021 0.2468 0.2449
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0215 0.0572
Brugia malayi Serotonin receptor 0.0022 0.0026 0.0076
Echinococcus multilocularis Tubulin alpha 1 chain 0.021 0.2468 0.2449
Loa Loa (eye worm) hypothetical protein 0.0078 0.075 0.2181
Brugia malayi hypothetical protein 0.0022 0.0026 0.0076
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.1155 0.3452
Schistosoma mansoni tubulin subunit beta 0.0278 0.3345 1
Leishmania major alpha tubulin 0.021 0.2468 0.7264
Plasmodium falciparum tubulin gamma chain 0.0151 0.1696 0.4931
Echinococcus multilocularis tubulin alpha 0.0151 0.1696 0.1675
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.014 0.0147
Toxoplasma gondii small ubiquitin family modifier, putative 0.0031 0.0146 0.0167
Loa Loa (eye worm) hypothetical protein 0.0128 0.14 0.414
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0171 0.0099
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0192 0.0573
Trypanosoma cruzi zeta tubulin, putative 0.0065 0.0593 0.1413
Giardia lamblia Epsilon tubulin 0.0065 0.0593 0.1396
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.021 0.0555
Loa Loa (eye worm) alpha-tubulin 0.021 0.2468 0.7358
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.1837 0.1816
Brugia malayi Tubulin alpha chain 0.0065 0.0593 0.1771
Toxoplasma gondii alpha tubulin TUBA1 0.021 0.2468 0.7304
Brugia malayi RNA binding protein 0.0063 0.0555 0.1658
Toxoplasma gondii beta-1 tubulin, putative 0.0278 0.3345 1
Brugia malayi Tubulin beta chain 0.0065 0.0593 0.1771
Entamoeba histolytica hypothetical protein 0.0043 0.0308 0.0506
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0215 0.0572
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.021 0.0363
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0192 0.0167
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0215 0.0237
Echinococcus granulosus tubulin alpha chain 0.021 0.2468 0.7358
Trichomonas vaginalis tubulin beta chain, putative 0.0085 0.0849 0.2198
Leishmania major alpha tubulin 0.021 0.2468 0.7264
Mycobacterium ulcerans putative regulatory protein 0.0044 0.0315 0.1863
Brugia malayi follicle stimulating hormone receptor 0.0022 0.0026 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.091 0.2663
Echinococcus multilocularis Small ubiquitin modifier 2 0.0031 0.0146 0.0121
Schistosoma mansoni hypothetical protein 0.0034 0.0192 0.05
Leishmania major beta tubulin 0.0278 0.3345 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0065 0.0593 0.1539
Brugia malayi tubulin alpha-2 chain 0.021 0.2468 0.7378
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0278 0.3345 0.3328
Trichomonas vaginalis tubulin, putative 0.0085 0.0849 0.2198
Brugia malayi tubulin alpha chain - mouse 0.021 0.2468 0.7378
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0215 0.0237
Echinococcus granulosus Tubulin beta 2C chain 0.0278 0.3345 1
Brugia malayi hypothetical protein 0.0182 0.2106 0.6296
Brugia malayi Dopamine receptor 0.0022 0.0026 0.0076
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.075 1
Trypanosoma brucei beta tubulin 0.0278 0.3345 1
Echinococcus multilocularis tubulin alpha 3 chain 0.021 0.2468 0.2449
Loa Loa (eye worm) tubulin beta chain 0.0065 0.0593 0.1708
Brugia malayi hypothetical protein 0.0022 0.0026 0.0076
Brugia malayi putative neuropeptide receptor 0.0022 0.0026 0.0076
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0171 0.0244
Mycobacterium tuberculosis Cell division protein FtsZ 0.0065 0.0593 0.149
Leishmania major alpha tubulin 0.021 0.2468 0.7264
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.021 0.2468 0.7259
Schistosoma mansoni tubulin subunit alpha 0.021 0.2468 0.7358
Leishmania major beta tubulin 0.0278 0.3345 1
Giardia lamblia Alpha-tubulin 0.021 0.2468 0.7259
Schistosoma mansoni hypothetical protein 0.0205 0.2393 0.7131
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0026 0.0076
Toxoplasma gondii ABC1 family protein 0.0036 0.0215 0.038
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0555 0.1594
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.091 0.2663
Echinococcus multilocularis tubulin alpha chain 0.021 0.2468 0.2449
Schistosoma mansoni alpha tubulin 0.021 0.2468 0.7358
Giardia lamblia Alpha-tubulin 0.021 0.2468 0.7259
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0026 0.0076
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0555 0.1658
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0151 0.1696 0.4931
Loa Loa (eye worm) tubulin alpha chain 0.021 0.2468 0.7358
Echinococcus multilocularis beta tubulin 0.0278 0.3345 0.3328
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0215 0.0237
Trichomonas vaginalis tubulin gamma chain, putative 0.0278 0.3345 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.021 0.02
Trypanosoma brucei alpha tubulin, putative 0.0085 0.0849 0.2214
Loa Loa (eye worm) hypothetical protein 0.0036 0.0215 0.0572
Entamoeba histolytica tubulin gamma chain 0.0151 0.1696 0.4845
Echinococcus granulosus Tubulin beta 2C chain 0.0278 0.3345 1
Plasmodium falciparum alpha tubulin 2 0.021 0.2468 0.7304
Entamoeba histolytica hypothetical protein 0.0043 0.0308 0.0506
Entamoeba histolytica tubulin alpha-1 chain 0.021 0.2468 0.7259
Brugia malayi RE15519p 0.0022 0.0026 0.0076
Loa Loa (eye worm) hypothetical protein 0.021 0.2468 0.7358
Leishmania major beta tubulin 0.0278 0.3345 1
Leishmania major delta tubulin, putative 0.0065 0.0593 0.1413
Onchocerca volvulus 0.0036 0.0215 0.0913
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.021 0.0219
Loa Loa (eye worm) tubulin beta-2A chain 0.0278 0.3345 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.1837 0.5457
Echinococcus multilocularis geminin 0.0205 0.2393 0.2373
Echinococcus multilocularis tubulin alpha chain 0.021 0.2468 0.2449
Brugia malayi hypothetical protein 0.0022 0.0026 0.0076
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0215 0.0217
Brugia malayi AKH receptor 0.0022 0.0026 0.0076
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0404 0.4744
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0215 0.188
Echinococcus multilocularis tubulin alpha 1C chain 0.021 0.2468 0.2449
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.091 0.0886
Trichomonas vaginalis tubulin alpha chain, putative 0.0278 0.3345 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0085 0.0849 0.2198
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0181 0.0111
Trypanosoma cruzi tubulin gamma chain 0.0151 0.1696 0.4855
Schistosoma mansoni alpha-glucosidase 0.0139 0.1546 0.458
Toxoplasma gondii alpha-tubulin I, putative 0.021 0.2468 0.7304
Brugia malayi bHLH-PAS transcription factor 0.0044 0.0315 0.0941
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.021 0.0219
Loa Loa (eye worm) tubulin beta-1 chain 0.0278 0.3345 1
Leishmania major alpha tubulin 0.021 0.2468 0.7264
Trypanosoma cruzi epsilon tubulin, putative 0.0151 0.1696 0.4855
Schistosoma mansoni hypothetical protein 0.0074 0.0709 0.2059
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.075 0.2022
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1611 0.4775
Schistosoma mansoni alpha tubulin 0.021 0.2468 0.7358
Brugia malayi Dopamine receptor protein 2 0.0022 0.0026 0.0076
Loa Loa (eye worm) hypothetical protein 0.0034 0.0192 0.05
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.021 0.02
Trypanosoma brucei alpha tubulin 0.021 0.2468 0.7264
Leishmania major beta tubulin 0.0278 0.3345 1
Brugia malayi alpha-tubulin 0.021 0.2468 0.7378
Echinococcus granulosus tubulin beta 4A class IVa 0.0278 0.3345 1
Schistosoma mansoni tubulin subunit gamma 0.0151 0.1696 0.5032
Leishmania major alpha tubulin 0.021 0.2468 0.7264
Echinococcus granulosus Tubulin beta 2C chain 0.0278 0.3345 1
Schistosoma mansoni tubulin subunit beta 0.0065 0.0593 0.1708
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0404 0.0745
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2468 0.7259
Echinococcus granulosus Tubulin beta 2C chain 0.0278 0.3345 1
Plasmodium vivax small ubiquitin-related modifier, putative 0.0031 0.0146 0.0167
Schistosoma mansoni tubulin subunit beta 0.0278 0.3345 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.1617 0.4794
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2468 0.7259
Brugia malayi Probable ClpP-like protease 0.0078 0.075 0.2241
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0709 0.212
Leishmania major beta tubulin 0.0278 0.3345 1
Echinococcus granulosus tubulin gamma 1 chain 0.0151 0.1696 0.5032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.1155 0.3452
Loa Loa (eye worm) hypothetical protein 0.0113 0.1207 0.3558
Brugia malayi hypothetical protein 0.0022 0.0026 0.0076
Leishmania major beta tubulin 0.0278 0.3345 1
Plasmodium vivax tubulin alpha chain, putative 0.021 0.2468 0.7304
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0215 0.038
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0026 0.0076
Echinococcus multilocularis Tubulin beta 2C chain 0.0278 0.3345 0.3328
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0171 0.0099
Onchocerca volvulus 0.0045 0.0322 0.1423
Loa Loa (eye worm) hypothetical protein 0.0145 0.1617 0.4794
Trypanosoma brucei tubulin gamma chain 0.0151 0.1696 0.4855
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0593 0.1396
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0192 0.05
Loa Loa (eye worm) hypothetical protein 0.0036 0.0215 0.0572
Brugia malayi sulfakinin receptor protein 0.0022 0.0026 0.0076
Echinococcus multilocularis tubulin alpha chain 0.021 0.2468 0.2449
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.075 1
Trypanosoma cruzi alpha tubulin, putative 0.021 0.2468 0.7264
Echinococcus granulosus GPCR family 2 0.0034 0.0192 0.05
Leishmania major beta tubulin 0.0278 0.3345 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.075 0.5
Onchocerca volvulus 0.0128 0.14 0.6606
Trichomonas vaginalis tubulin alpha chain, putative 0.0151 0.1696 0.4845
Trichomonas vaginalis tubulin, putative 0.0065 0.0593 0.1396
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.091 0.2663
Brugia malayi hypothetical protein 0.0022 0.0026 0.0076
Loa Loa (eye worm) hypothetical protein 0.0109 0.1155 0.3402
Loa Loa (eye worm) tubulin beta chain 0.0278 0.3345 1
Brugia malayi Muscleblind-like protein 0.0145 0.1617 0.4834
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.021 0.0219
Plasmodium falciparum alpha tubulin 1 0.021 0.2468 0.7304
Loa Loa (eye worm) hypothetical protein 0.0112 0.12 0.3538
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0555 0.1594
Leishmania major beta tubulin 0.0278 0.3345 1
Brugia malayi beta-lactamase family protein 0.0036 0.0215 0.0644
Echinococcus granulosus tubulin alpha 3 chain 0.021 0.2468 0.7358
Brugia malayi neuropeptide F receptor 0.0022 0.0026 0.0076
Echinococcus granulosus beta tubulin 0.0278 0.3345 1
Brugia malayi MH2 domain containing protein 0.0144 0.1611 0.4815
Loa Loa (eye worm) hypothetical protein 0.0145 0.1622 0.4807
Echinococcus granulosus aryl hydrocarbon receptor 0.0128 0.1407 0.416
Loa Loa (eye worm) hypothetical protein 0.0036 0.0215 0.0572
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0555 0.053
Schistosoma mansoni tubulin subunit alpha 0.021 0.2468 0.7358
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2468 0.7259
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0181 0.0542
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0192 0.05
Leishmania major beta tubulin 0.0278 0.3345 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0308 0.085
Onchocerca volvulus 0.0036 0.0215 0.0913
Plasmodium falciparum small ubiquitin-related modifier 0.0031 0.0146 0.0167
Trichomonas vaginalis tubulin, putative 0.0085 0.0849 0.2198
Entamoeba histolytica tubulin family protein 0.0278 0.3345 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.091 0.2663
Leishmania major epsilon tubulin, putative 0.0151 0.1696 0.4855
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.021 0.02
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.014 0.0147
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0031 0.0146 0.0363
Brugia malayi hypothetical protein 0.0043 0.0308 0.092
Mycobacterium ulcerans cell division protein FtsZ 0.0065 0.0593 0.7059
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0215 0.0572
Echinococcus multilocularis hypothetical protein 0.021 0.2468 0.2449
Echinococcus multilocularis tubulin beta 1 chain 0.0278 0.3345 0.3328
Giardia lamblia Beta tubulin 0.0278 0.3345 1
Toxoplasma gondii beta-tubulin, putative 0.0278 0.3345 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0215 0.0217
Loa Loa (eye worm) alpha-tubulin 0.021 0.2468 0.7358
Loa Loa (eye worm) hypothetical protein 0.0036 0.0215 0.0572
Trypanosoma brucei alpha tubulin 0.021 0.2468 0.7264
Echinococcus granulosus tubulin alpha 1C chain 0.021 0.2468 0.7358
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.075 0.0726
Trichomonas vaginalis tubulin epsilon chain, putative 0.0278 0.3345 1
Brugia malayi hypothetical protein 0.0022 0.0026 0.0076
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2468 0.7259
Echinococcus multilocularis tubulin subunit TubB 0.021 0.2468 0.2449
Plasmodium vivax tubulin gamma chain, putative 0.0151 0.1696 0.4931
Plasmodium vivax tubulin beta chain, putative 0.0278 0.3345 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0151 0.1696 0.4845
Trypanosoma brucei zeta tubulin 0.0065 0.0593 0.1413
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0404 0.0745
Echinococcus multilocularis beta tubulin 0.0278 0.3345 0.3328
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0171 0.0099
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.075 1
Schistosoma mansoni rotamase 0.0034 0.0181 0.047
Brugia malayi larval opioid receptor 0.0022 0.0026 0.0076
Brugia malayi Dopamine receptor protein 1 0.0022 0.0026 0.0076
Echinococcus multilocularis aryl hydrocarbon receptor 0.0128 0.1407 0.1385
Trichomonas vaginalis rotamase, putative 0.0033 0.0171 0.0079
Trichomonas vaginalis tubulin beta chain, putative 0.0278 0.3345 1
Plasmodium vivax delta tubulin, putative 0.0065 0.0593 0.1539
Loa Loa (eye worm) hypothetical protein 0.0074 0.0709 0.2059
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.021 0.0555
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0215 0.0217
Loa Loa (eye worm) hypothetical protein 0.0036 0.0215 0.0572
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2468 0.7259
Echinococcus granulosus alpha tubulin 0.021 0.2468 0.7358
Brugia malayi TAR-binding protein 0.0063 0.0555 0.1658
Echinococcus multilocularis tubulin alpha chain 0.021 0.2468 0.2449
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.2746 1
Echinococcus granulosus tubulin beta 1 chain 0.0278 0.3345 1
Loa Loa (eye worm) hypothetical protein 0.003 0.014 0.0343
Leishmania major alpha tubulin 0.021 0.2468 0.7264
Leishmania major alpha tubulin 0.021 0.2468 0.7264
Onchocerca volvulus 0.0094 0.0955 0.4469
Onchocerca volvulus 0.0182 0.2106 1
Giardia lamblia Beta tubulin 0.0278 0.3345 1
Brugia malayi PAS domain containing protein 0.0059 0.0515 0.1539
Trichomonas vaginalis tubulin epsilon chain, putative 0.021 0.2468 0.7259
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0112 0.12 0.3588
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0192 0.0573
Schistosoma mansoni alpha glucosidase 0.0036 0.021 0.0555
Leishmania major beta tubulin 0.0278 0.3345 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0085 0.0849 0.2198
Echinococcus granulosus Tubulin alpha 1 chain 0.021 0.2468 0.7358
Echinococcus granulosus tar DNA binding protein 0.0063 0.0555 0.1594
Echinococcus granulosus Tubulin alpha 1 chain 0.021 0.2468 0.7358
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0404 0.114
Schistosoma mansoni tubulin subunit alpha 0.021 0.2468 0.7358
Echinococcus granulosus tubulin alpha 0.0151 0.1696 0.5032
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0555 0.1594
Echinococcus multilocularis Tubulin beta 2C chain 0.0278 0.3345 0.3328
Leishmania major beta tubulin 0.0278 0.3345 1
Leishmania major alpha tubulin 0.021 0.2468 0.7264

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.