Detailed information for compound 565972

Basic information

Technical information
  • TDR Targets ID: 565972
  • Name: (2S,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R, 4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)t etrahydropyran-2-yl]oxy-hexanal
  • MW: 342.296 | Formula: C12H22O11
  • H donors: 8 H acceptors: 9 LogP: -5.02 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]([C@H]([C@@H]([C@@H](C=O)O)O)O[C@H]1O[C@H](CO)[C@@H]([C@@H]([C@H]1O)O)O)O
  • InChi: 1S/C12H22O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h1,4-12,14-21H,2-3H2/t4-,5-,6-,7-,8+,9+,10-,11-,12+/m1/s1
  • InChiKey: DKXNBNKWCZZMJT-QMRWEYQWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]hexanal
  • (2S,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hexanal
  • (2S,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-hexanal
  • (2S,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanal
  • epilactose
  • 4-O-alpha-D-galactopyranosyl-D-galactose
  • 50468-56-9
  • 4-O-beta-D-Galactopyranosyl-D-mannose
  • D-Mannose, 4-O-beta-D-galactopyranosyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax vivapain-2 0.0037 0.0083 0.0079
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0754 0.5002 0.5
Brugia malayi MH1 domain containing protein 0.0027 0.0011 0.0007
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0112 0.0596 0.0596
Trypanosoma cruzi major cysteine proteinase, putative 0.0111 0.0588 0.0585
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0112 0.0596 0.0243
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0147 0.0143
Loa Loa (eye worm) hypothetical protein 0.0144 0.0816 0.0813
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0177 0.0095
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.09 0.0896
Brugia malayi MH2 domain containing protein 0.0389 0.2499 0.2496
Echinococcus multilocularis Smad4 0.0027 0.0011 0.0011
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.09 0.0896
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0011 0.0011
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0147 0.0143
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0112 0.0596 0.0596
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0667 0.4405 1
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0667 0.4405 0.4403
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0056 0.0215 0.0215
Echinococcus multilocularis musashi 0.0116 0.0628 0.0628
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0572 0.0401
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.1273 0.1269
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0572 0.0568
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0572 0.0401
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1482 1 1
Brugia malayi beta-lactamase family protein 0.0108 0.0572 0.0568
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.008 0.008
Leishmania major cathepsin L-like protease 0.0141 0.0795 0.0791
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0572 0.0401
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0104 0.0544 0.0541
Brugia malayi beta-lactamase 0.0108 0.0572 0.0568
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0454 0.045
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0361 0.0699
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0572 0.0572
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1482 1 1
Echinococcus granulosus tar DNA binding protein 0.0063 0.026 0.026
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase) 0.0169 0.0988 0.0824
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0361 0.0361
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0498 0.3247 0.2994
Loa Loa (eye worm) fibroinase 0.0037 0.0083 0.0079
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1482 1 1
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Brugia malayi Bromodomain containing protein 0.0087 0.0424 0.042
Brugia malayi acetyltransferase, GNAT family protein 0.0166 0.0968 0.0965
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0361 0.0361
Mycobacterium leprae Probable lipase LipE 0.0108 0.0572 0.1273
Loa Loa (eye worm) polyprenyl synthetase 0.1482 1 1
Trypanosoma cruzi polyprenyl synthase, putative 0.0754 0.5002 0.5
Echinococcus multilocularis tar DNA binding protein 0.0063 0.026 0.026
Trichomonas vaginalis esterase, putative 0.0108 0.0572 0.0493
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0754 0.5002 0.5
Brugia malayi MAP kinase sur-1 0.0052 0.0186 0.0182
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0572 0.0568
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0083 0.0083
Echinococcus granulosus lamin dm0 0.0116 0.0628 0.0628
Trypanosoma cruzi cruzipain precursor, putative 0.0141 0.0795 0.0791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0083 0.0007
Echinococcus granulosus smad 0.0027 0.0011 0.0011
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0067 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0054 0.02 0.0196
Echinococcus granulosus cathepsin l1 0.0037 0.0083 0.0083
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0361 0.0361
Schistosoma mansoni microtubule-associated protein tau 0.1412 0.9516 0.9516
Schistosoma mansoni lamin 0.0116 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.0624
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0572 0.0401
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0691 0.4573 0.4475
Echinococcus granulosus microtubule associated protein 2 0.1412 0.9516 0.9516
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0186 0.0186
Loa Loa (eye worm) ctsf protein 0.0037 0.0083 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0186 0.0186
Schistosoma mansoni bromodomain containing protein 0.0074 0.0336 0.0336
Brugia malayi intermediate filament protein 0.0116 0.0628 0.0624
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1482 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.008 0.008
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0572 0.0572
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0186 0.0182
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0083 0.0083
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0454 0.0454
Onchocerca volvulus 0.0116 0.0628 1
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Plasmodium falciparum cysteine proteinase falcipain 3 0.0037 0.0083 0.0079
Mycobacterium tuberculosis Conserved protein 0.0108 0.0572 0.0401
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0572 0.1273
Loa Loa (eye worm) polyprenyl synthetase 0.0667 0.4405 0.4403
Echinococcus multilocularis lamin 0.0116 0.0628 0.0628
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0454 0.0454
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0454 0.045
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0754 0.5002 0.5002
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0104
Loa Loa (eye worm) cysteine protease 0.0037 0.0083 0.0079
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0178 0.0178
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.026 0.0256
Trypanosoma brucei mitochondrial DNA polymerase beta 0.033 0.2091 0.2088
Leishmania major cysteine peptidase A (CPA) 0.0037 0.0083 0.0079
Mycobacterium ulcerans hypothetical protein 0.0174 0.1021 0.0684
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0572 0.0401
Plasmodium vivax vivapain-2 0.0037 0.0083 0.0079
Toxoplasma gondii ABC1 family protein 0.0108 0.0572 0.0568
Onchocerca volvulus 0.0116 0.0628 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0104
Schistosoma mansoni lamin 0.0116 0.0628 0.0628
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0667 0.4405 0.4403
Schistosoma mansoni smad 0.0027 0.0011 0.0011
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0186 0.0182
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0286 0.0282
Schistosoma mansoni hypothetical protein 0.0067 0.0286 0.0286
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0498 0.3247 0.3247
Echinococcus multilocularis zinc finger protein 0.0026 0.0005 0.0005
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0049 0.0165 0.0161
Treponema pallidum octaprenyl-diphosphate synthase 0.0754 0.5002 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0013 0.0009
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0572 0.0568
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0454 0.0454
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1482 1 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0166 0.0968 0.0968
Loa Loa (eye worm) MH2 domain-containing protein 0.0389 0.2499 0.2496
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Brugia malayi latrophilin 2 splice variant baaae 0.0144 0.0816 0.0813
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0186 0.0182
Schistosoma mansoni smad1 5 8 and 0.0027 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Schistosoma mansoni trans-prenyltransferase 0.0667 0.4405 0.4405
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0083 0.0083
Mycobacterium tuberculosis Conserved protein 0.0108 0.0572 0.0401
Schistosoma mansoni smad1 5 8 and 0.0027 0.0011 0.0011
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0286 0.0282
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1482 1 1
Echinococcus multilocularis microtubule associated protein 2 0.1412 0.9516 0.9516
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0177 0.0173
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0498 0.3247 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0147 0.0143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Echinococcus granulosus GPCR family 2 0.0067 0.0286 0.0286
Mycobacterium tuberculosis Conserved protein 0.0108 0.0572 0.0401
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1482 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.0795 0.0791
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0454 0.0454
Mycobacterium ulcerans hypothetical protein 0.0108 0.0572 0.0218
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0572 0.0493
Toxoplasma gondii hypothetical protein 0.0053 0.0194 0.019
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.2091 0.2088
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0083 0.0079
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0572 0.0568
Loa Loa (eye worm) hypothetical protein 0.0042 0.012 0.0116
Leishmania major hypothetical protein, conserved 0.0108 0.0572 0.0568
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0186 0.0055
Onchocerca volvulus 0.0108 0.0572 0.897
Loa Loa (eye worm) acetyltransferase 0.0166 0.0968 0.0965
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0572 0.0568
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0104
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0361 0.0357
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0572 0.0493
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Brugia malayi MH2 domain containing protein 0.0027 0.0011 0.0007
Echinococcus multilocularis cysteine protease 0.0037 0.0083 0.0083
Leishmania major cathepsin L-like protease 0.0141 0.0795 0.0791
Brugia malayi TAR-binding protein 0.0063 0.026 0.0256
Leishmania major solanesyl-diphosphate synthase, putative 0.0667 0.4405 0.4403
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0667 0.4405 0.4403
Mycobacterium ulcerans lipase LipD 0.0108 0.0572 0.0218
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0186 0.0182
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1482 1 1
Schistosoma mansoni hypothetical protein 0.0067 0.0286 0.0286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0083 0.0083
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0217 0.0213
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0178 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Leishmania major mitochondrial DNA polymerase beta 0.033 0.2091 0.2088
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0667 0.4405 1
Schistosoma mansoni hypothetical protein 0.0144 0.0816 0.0816
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0186 0.0182
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0186 0.0186
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0083 0.0083
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0498 0.3247 0.7136
Brugia malayi hypothetical protein 0.0036 0.008 0.0076
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0754 0.5002 0.5002
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0112 0.0596 0.0592
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0572 0.0493
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0112 0.0596 0.0592
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0498 0.3247 0.3125
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0177 0.0173
Echinococcus granulosus Smad4 0.0027 0.0011 0.0011
Echinococcus multilocularis cysteine protease 0.0037 0.0083 0.0083
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0286 0.0286
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0667 0.4405 0.4403
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0357
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1482 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0572 0.0572
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1482 1 1
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1482 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0286 0.0286
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0186 0.0186
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0083 0.0083
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0572 0.0218
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.1273 0.1269
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0498 0.3247 0.3125
Echinococcus granulosus lamin 0.0116 0.0628 0.0628
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0132 0.012
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0572 0.0401
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0147 0.0143
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1482 1 1
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0667 0.4405 1
Loa Loa (eye worm) Smad1 0.0027 0.0011 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0186 0.0182
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0498 0.3247 0.3125
Echinococcus multilocularis GPCR, family 2 0.0067 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Brugia malayi MH2 domain containing protein 0.0027 0.0011 0.0007
Echinococcus granulosus cathepsin l cysteine peptidase 0.0037 0.0083 0.0083
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0056 0.0215 0.0211
Echinococcus granulosus intermediate filament protein 0.0116 0.0628 0.0628
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0078 0.0364 0.0361
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0754 0.5002 0.5002
Brugia malayi Polyprenyl synthetase family protein 0.0667 0.4405 0.4403
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0361 0.0794
Echinococcus granulosus zinc finger protein 0.0026 0.0005 0.0005
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0361 0.0357
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0572 0.0401
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0178 0.0377
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0177 0.0095
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0186 0.0182
Toxoplasma gondii hypothetical protein 0.0027 0.0013 0.0009
Echinococcus granulosus cathepsin L cysteine proteinase 0.0037 0.0083 0.0083
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0177 0.0173
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0083 0.0079
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.026 0.0256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0454 0.0454
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0667 0.4405 0.4196
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Brugia malayi Smad1 0.0027 0.0011 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0667 0.4405 0.4403
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0112 0.0596 0.0596
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Brugia malayi MH1 domain containing protein 0.0027 0.0011 0.0007
Brugia malayi Intermediate filament tail domain containing protein 0.0116 0.0628 0.0624
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0667 0.4405 0.4403
Loa Loa (eye worm) intermediate filament protein 0.0116 0.0628 0.0624
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Echinococcus multilocularis smad 0.0027 0.0011 0.0011
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0011 0.0011
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0056 0.0215 0.0215
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.0795 0.0791
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0037 0.0083 0.0079
Schistosoma mansoni smad1 5 8 and 0.0027 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.1021 0.0858
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0286 0.0282
Loa Loa (eye worm) transcription factor SMAD2 0.0389 0.2499 0.2496
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0186 0.0182
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0572 0.0572
Onchocerca volvulus 0.0108 0.0572 0.897
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0361 0.0357
Loa Loa (eye worm) beta-lactamase 0.0108 0.0572 0.0568
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0116 0.0628 0.0624
Entamoeba histolytica cysteine protease, putative 0.0037 0.0083 0.0007
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0062 0.0257 0.0253
Schistosoma mansoni zinc finger protein 0.0026 0.0005 0.0005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0011 0.0007
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0177 0.0177
Trypanosoma brucei protein kinase, putative 0.0052 0.0186 0.0182
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0572 0.0218
Brugia malayi cytoplasmic intermediate filament protein 0.0062 0.0257 0.0253
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0011 0.0007
Leishmania major polyprenyl synthase, putative 0.0754 0.5002 0.5
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0013 0.0009
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0667 0.4405 0.4405
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.008 0.008
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.1273 0.1269
Onchocerca volvulus 0.0108 0.0572 0.897
Brugia malayi Probable ClpP-like protease 0.0078 0.0361 0.0357
Leishmania major farnesyl pyrophosphate synthase 0.1482 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0083 0.0007
Loa Loa (eye worm) hypothetical protein 0.0114 0.0613 0.061
Trypanosoma cruzi polyprenyl synthase, putative 0.0754 0.5002 0.5
Echinococcus multilocularis lamin dm0 0.0116 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0067 0.0286 0.0282
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.0795 0.0791
Schistosoma mansoni glutathione synthetase 0.0498 0.3247 0.3247
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1482 1 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0156 0.09 0.0896
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0054 0.02 0.0196
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1482 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.2091 0.2088
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0667 0.4405 0.4403
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0309 0.0309
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0572 0.0493
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0454 0.0454
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0132 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Schistosoma mansoni intermediate filament proteins 0.0116 0.0628 0.0628
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0186 0.0186
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0572 0.0568
Loa Loa (eye worm) RNA binding protein 0.0063 0.026 0.0256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0083 0.0079
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0112 0.0596 0.0243
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0129 0.0711 0.0708
Schistosoma mansoni hypothetical protein 0.0067 0.0286 0.0286
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0498 0.3247 0.7323
Brugia malayi beta-lactamase family protein 0.0108 0.0572 0.0568
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0498 0.3247 0.3247
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0112 0.0596 0.0425
Echinococcus granulosus histone acetyltransferase KAT2B 0.0159 0.0919 0.0919
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0037 0.0083 0.0079
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0667 0.4405 0.4405
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1482 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.018 0.0176
Brugia malayi Bromodomain containing protein 0.0046 0.0147 0.0143
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0186 0.0182
Brugia malayi RNA binding protein 0.0063 0.026 0.0256
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0166 0.0968 0.0968
Leishmania major cathepsin L-like protease 0.0141 0.0795 0.0791
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0667 0.4405 1
Loa Loa (eye worm) TAR-binding protein 0.0063 0.026 0.0256
Loa Loa (eye worm) hypothetical protein 0.021 0.1273 0.1269
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0361 0.0357
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0101 0.0101
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0572 0.0493
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0037 0.0083 0.0079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0454 0.0454
Toxoplasma gondii cathepsin CPL 0.0037 0.0083 0.0079
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0309 0.0309
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Giardia lamblia Farnesyl diphosphate synthase 0.1482 1 1
Schistosoma mansoni Smad4 0.0027 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Brugia malayi PHD-finger family protein 0.0031 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Mycobacterium ulcerans beta-lactamase 0.0108 0.0572 0.0218

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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