Detailed information for compound 59285

Basic information

Technical information
  • TDR Targets ID: 59285
  • Name: (2S)-2-(3-oxo-1H-isoindol-2-yl)propanoic acid
  • MW: 205.21 | Formula: C11H11NO3
  • H donors: 1 H acceptors: 3 LogP: 0.95 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@@H](N1Cc2c(C1=O)cccc2)C
  • InChi: 1S/C11H11NO3/c1-7(11(14)15)12-6-8-4-2-3-5-9(8)10(12)13/h2-5,7H,6H2,1H3,(H,14,15)/t7-/m0/s1
  • InChiKey: XBPWPQBDGZFHQI-ZETCQYMHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-(1-oxoisoindolin-2-yl)propanoic acid
  • (2S)-2-(1-oxo-2-isoindolinyl)propanoic acid
  • (2S)-2-(1-ketoisoindolin-2-yl)propionic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0039 0.0009 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0009 0.002
Leishmania major beta tubulin 0.059 0.3952 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0039 0.0009 0.0023
Onchocerca volvulus 0.0039 0.0009 0.01
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0226 0.1343 0.3399
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0226 0.1343 0.3398
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.012 0.0214
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Schistosoma mansoni coup transcription factor 0.0038 0.0001 0.0002
Brugia malayi G-protein coupled receptor 0.0039 0.0009 0.0009
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0009 0.002
Mycobacterium tuberculosis Cell division protein FtsZ 0.0116 0.0558 0.0406
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0226 0.1343 0.2315
Trichomonas vaginalis tubulin alpha chain, putative 0.0267 0.164 0.3188
Toxoplasma gondii aldehyde dehydrogenase 0.0229 0.137 0.2469
Echinococcus granulosus g protein coupled receptor 0.0039 0.0009 0.002
Brugia malayi Cytochrome P450 family protein 0.0212 0.1245 0.1245
Echinococcus multilocularis tubulin beta 1 chain 0.059 0.3952 1
Schistosoma mansoni hypothetical protein 0.0122 0.0599 0.1515
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0009 0.002
Leishmania major alpha tubulin 0.032 0.2017 0.4952
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Schistosoma mansoni tubulin subunit beta 0.059 0.3952 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0009 0.002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0001 0.0001
Onchocerca volvulus 0.0039 0.0009 0.01
Brugia malayi Serotonin receptor 0.0039 0.0009 0.0009
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0226 0.1343 0.3339
Mycobacterium leprae cell division protein FtsZ 0.0116 0.0558 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0009 0.0023
Trypanosoma cruzi cytochrome P450, putative 0.0212 0.1245 0.3089
Leishmania major cytochrome p450-like protein 0.0212 0.1245 0.2938
Echinococcus granulosus tubulin alpha 3 chain 0.032 0.2017 0.5103
Loa Loa (eye worm) BEN-1 protein 0.059 0.3952 0.3951
Trypanosoma brucei tubulin delta chain 0.0116 0.0558 0.1143
Brugia malayi Tubulin alpha-2 chain 0.032 0.2017 0.2017
Leishmania major alpha tubulin 0.032 0.2017 0.4952
Mycobacterium ulcerans aldehyde dehydrogenase 0.0229 0.137 1
Trichomonas vaginalis tubulin beta chain, putative 0.032 0.2017 0.43
Loa Loa (eye worm) hypothetical protein 0.032 0.2017 0.2016
Onchocerca volvulus 0.0039 0.0009 0.01
Onchocerca volvulus 0.0039 0.0009 0.01
Trichomonas vaginalis tubulin alpha chain, putative 0.059 0.3952 1
Loa Loa (eye worm) tubulin beta-2A chain 0.059 0.3952 0.3951
Schistosoma mansoni thyroid hormone receptor 0.016 0.0872 0.2207
Loa Loa (eye worm) cytochrome P450 family protein 0.0212 0.1245 0.1245
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0009 0.002
Echinococcus granulosus neuropeptide receptor 0.0039 0.0009 0.002
Leishmania major beta tubulin 0.059 0.3952 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0212 0.1245 0.8531
Trypanosoma brucei epsilon tubulin 0.0267 0.164 0.3966
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0009 0.0023
Trichomonas vaginalis tubulin epsilon chain, putative 0.032 0.2017 0.43
Leishmania major beta tubulin 0.059 0.3952 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Schistosoma mansoni tubulin subunit beta 0.059 0.3952 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0039 0.0009 0.0023
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0226 0.1343 0.2315
Schistosoma mansoni biogenic amine receptor 0.0039 0.0009 0.0023
Brugia malayi Tubulin gamma chain 0.0267 0.164 0.164
Trypanosoma cruzi tubulin delta chain 0.0116 0.0558 0.1333
Schistosoma mansoni biogenic amine receptor 0.0039 0.0009 0.0023
Loa Loa (eye worm) tubulin beta chain 0.059 0.3952 0.3951
Brugia malayi Tubulin beta-1 chain 0.059 0.3952 0.3952
Echinococcus multilocularis peroxisome assembly protein 26 0.032 0.2017 0.5103
Echinococcus multilocularis tubulin alpha 1C chain 0.032 0.2017 0.5103
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0009 0.002
Brugia malayi putative neuropeptide receptor NPR1 0.0039 0.0009 0.0009
Entamoeba histolytica tubulin alpha-1 chain 0.032 0.2017 0.2583
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Echinococcus granulosus Tubulin beta 2C chain 0.059 0.3952 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0229 0.137 0.3262
Echinococcus multilocularis dro:myosuppressin receptor 0.0039 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Echinococcus granulosus alpha 1A adrenergic receptor 0.0039 0.0009 0.002
Echinococcus multilocularis allatostatin A receptor 0.0039 0.0009 0.002
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0267 0.164 0.3256
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0039 0.0009 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0009 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0001 0.0001
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0001 0.0001
Trypanosoma brucei alpha tubulin 0.032 0.2017 0.4952
Brugia malayi nuclear receptor NHR-88 0.0038 0.0001 0.0001
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0039 0.0009 0.002
Schistosoma mansoni amine GPCR 0.0039 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0039 0.0009 0.0009
Onchocerca volvulus 0.0039 0.0009 0.01
Leishmania major alpha tubulin 0.032 0.2017 0.4952
Echinococcus granulosus tubulin alpha 3 chain 0.032 0.2017 0.5103
Brugia malayi Cytochrome P450 family protein 0.0111 0.0523 0.0523
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0009 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Trichomonas vaginalis tubulin alpha chain, putative 0.0151 0.0809 0.0742
Leishmania major beta tubulin 0.059 0.3952 1
Brugia malayi Nuclear hormone receptor-like 1 0.0269 0.1651 0.1651
Schistosoma mansoni tubulin subunit alpha 0.032 0.2017 0.5104
Leishmania major alpha tubulin 0.032 0.2017 0.4952
Echinococcus granulosus Tubulin alpha 1 chain 0.032 0.2017 0.5103
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Onchocerca volvulus Neuropeptide F receptor homolog 0.0039 0.0009 0.01
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Schistosoma mansoni amine GPCR 0.0039 0.0009 0.0023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0001 0.0001
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0039 0.0009 0.002
Echinococcus granulosus tubulin alpha chain 0.032 0.2017 0.5103
Leishmania major beta tubulin 0.059 0.3952 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0039 0.0009 0.0023
Echinococcus granulosus tubulin alpha chain 0.032 0.2017 0.5103
Loa Loa (eye worm) tubulin alpha chain 0.032 0.2017 0.2016
Trypanosoma brucei beta tubulin 0.059 0.3952 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Schistosoma mansoni alpha tubulin 0.032 0.2017 0.5104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0226 0.1343 0.2315
Echinococcus multilocularis Tubulin alpha 1 chain 0.032 0.2017 0.5103
Echinococcus multilocularis tubulin epsilon chain 0.0267 0.164 0.4148
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0009 0.002
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0111 0.0523 0.1245
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Loa Loa (eye worm) beta-tubulin 0.059 0.3952 0.3951
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0039 0.0009 0.0023
Echinococcus multilocularis tubulin alpha chain 0.032 0.2017 0.5103
Echinococcus multilocularis tubulin subunit TubB 0.032 0.2017 0.5103
Toxoplasma gondii alpha tubulin TUBA1 0.032 0.2017 0.4357
Echinococcus granulosus beta tubulin 0.059 0.3952 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0009 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0009 0.002
Echinococcus granulosus orexin receptor type 2 0.0039 0.0009 0.002
Trypanosoma cruzi epsilon tubulin, putative 0.0267 0.164 0.4096
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0116 0.0558 0.01
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0009 0.0023
Trypanosoma brucei alpha tubulin, putative 0.0151 0.0809 0.18
Echinococcus multilocularis ubiquitin specific protease 41 0.0226 0.1343 0.3398
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0001 0.0002
Echinococcus multilocularis tubulin gamma 1 chain 0.0267 0.164 0.4148
Trypanosoma brucei alpha tubulin 0.032 0.2017 0.4952
Brugia malayi Dopamine receptor protein 2 0.0039 0.0009 0.0009
Onchocerca volvulus 0.0039 0.0009 0.01
Entamoeba histolytica tubulin family protein 0.059 0.3952 1
Echinococcus granulosus tubulin gamma 1 chain 0.0267 0.164 0.4148
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.1343 0.2315
Brugia malayi hypothetical protein 0.0183 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0001 0.0001
Plasmodium vivax tubulin epsilon chain, putative 0.0267 0.164 0.3188
Plasmodium vivax tubulin alpha chain, putative 0.032 0.2017 0.43
Schistosoma mansoni histamine h1 receptor 0.0039 0.0009 0.0023
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0039 0.0009 0.0023
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0009 0.002
Leishmania major beta tubulin 0.059 0.3952 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0009 0.002
Leishmania major alpha tubulin 0.032 0.2017 0.4952
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0039 0.0009 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0009 0.002
Echinococcus multilocularis Tubulin beta 2C chain 0.059 0.3952 1
Echinococcus granulosus tubulin alpha 1C chain 0.032 0.2017 0.5103
Loa Loa (eye worm) alpha-tubulin 0.032 0.2017 0.2016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0001 0.0001
Schistosoma mansoni adenoreceptor 0.0039 0.0009 0.0023
Echinococcus multilocularis beta tubulin 0.059 0.3952 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0039 0.0009 0.002
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0009 0.002
Trichomonas vaginalis tubulin beta chain, putative 0.032 0.2017 0.43
Brugia malayi tubulin alpha-2 chain 0.032 0.2017 0.2017
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0229 0.137 0.3465
Onchocerca volvulus 0.0039 0.0009 0.01
Brugia malayi Cell division protein ftsZ 0.0116 0.0558 0.0558
Schistosoma mansoni tubulin subunit delta 0.0116 0.0558 0.1411
Toxoplasma gondii alpha-tubulin I, putative 0.032 0.2017 0.4357
Loa Loa (eye worm) cytochrome P450 family protein 0.0213 0.1251 0.125
Loa Loa (eye worm) hypothetical protein 0.0101 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0183 0.1042 0.1041
Echinococcus granulosus g-protein coupled receptor 0.0039 0.0009 0.002
Echinococcus granulosus serotonin receptor 0.0039 0.0009 0.002
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0039 0.0009 0.0009
Echinococcus granulosus neuropeptide receptor A26 0.0039 0.0009 0.002
Brugia malayi hypothetical protein 0.0039 0.0009 0.0009
Leishmania major beta tubulin 0.059 0.3952 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0009 0.0023
Schistosoma mansoni neuropeptide receptor 0.0039 0.0009 0.0023
Loa Loa (eye worm) BEN-1 protein 0.059 0.3952 0.3951
Schistosoma mansoni tubulin subunit gamma 0.0267 0.164 0.4149
Echinococcus multilocularis neuropeptide s receptor 0.0039 0.0009 0.002
Schistosoma mansoni alpha-1 adrenergic receptor 0.0039 0.0009 0.0023
Schistosoma mansoni opsin-like receptor 0.0039 0.0009 0.0023
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0009 0.002
Schistosoma mansoni growth hormone secretagogue receptor 0.0039 0.0009 0.0023
Echinococcus multilocularis beta tubulin 0.059 0.3952 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0039 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0169 0.0935 0.0934
Brugia malayi Cytochrome P450 family protein 0.0212 0.1245 0.1245
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0009 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.0251 0.1522 0.1522
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0001 0.0002
Brugia malayi Tubulin beta chain 0.0151 0.0809 0.0809
Schistosoma mansoni amine GPCR 0.0039 0.0009 0.0023
Brugia malayi neuropeptide F receptor 0.0039 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0116 0.0558 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0009 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0001 0.0001
Trichomonas vaginalis tubulin gamma chain, putative 0.059 0.3952 1
Echinococcus granulosus tubulin alpha chain 0.032 0.2017 0.5103
Schistosoma mansoni tubulin subunit beta 0.0116 0.0558 0.1411
Schistosoma mansoni amine GPCR 0.0039 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0039 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0039 0.0009 0.0023
Loa Loa (eye worm) cytochrome P450 0.0111 0.0523 0.0522
Plasmodium falciparum tubulin beta chain 0.059 0.3952 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0226 0.1343 0.3339
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Trypanosoma brucei epsilon tubulin 0.0267 0.164 0.3966
Schistosoma mansoni hypothetical protein 0.0039 0.0009 0.0023
Echinococcus granulosus g protein coupled receptor 0.0039 0.0009 0.002
Echinococcus granulosus hypothetical protein 0.0039 0.0009 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0009 0.002
Brugia malayi neuropeptide F receptor 0.0039 0.0009 0.0009
Trypanosoma cruzi zeta tubulin, putative 0.0116 0.0558 0.1333
Schistosoma mansoni neuropeptide receptor 0.0039 0.0009 0.0023
Echinococcus granulosus dro:myosuppressin receptor 0.0039 0.0009 0.002
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0204 0.1187 0.1854
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0001 0.0001
Toxoplasma gondii beta-tubulin, putative 0.059 0.3952 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0009 0.0008
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0226 0.1343 0.1343
Leishmania major alpha tubulin 0.032 0.2017 0.4952
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Giardia lamblia Beta tubulin 0.059 0.3952 1
Schistosoma mansoni opsin-like receptor 0.0039 0.0009 0.0023
Echinococcus multilocularis tubulin alpha 3 chain 0.032 0.2017 0.5103
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0111 0.0523 0.1053
Echinococcus multilocularis sex peptide receptor 0.0039 0.0009 0.002
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0009 0.002
Trypanosoma brucei alpha tubulin 0.032 0.2017 0.4952
Toxoplasma gondii beta tubulin 0.059 0.3952 1
Brugia malayi hypothetical protein 0.0039 0.0009 0.0009
Brugia malayi Tubulin alpha-2 chain 0.032 0.2017 0.2017
Leishmania major beta tubulin 0.059 0.3952 1
Trypanosoma brucei tubulin gamma chain 0.0267 0.164 0.3966
Schistosoma mansoni opsin-like receptor 0.0039 0.0009 0.0023
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1434 1 1
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0009 0.002
Giardia lamblia Alpha-tubulin 0.032 0.2017 0.43
Echinococcus granulosus tubulin alpha 1C chain 0.032 0.2017 0.5103
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0111 0.0523 0.1245
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Schistosoma mansoni tubulin subunit beta 0.059 0.3952 1
Onchocerca volvulus 0.0039 0.0009 0.01
Plasmodium vivax tubulin beta chain, putative 0.059 0.3952 1
Brugia malayi Dopamine receptor 0.0039 0.0009 0.0009
Onchocerca volvulus 0.0039 0.0009 0.01
Trypanosoma cruzi tubulin gamma chain 0.0267 0.164 0.4096
Schistosoma mansoni myosin xvIII 0.0039 0.0009 0.0023
Onchocerca volvulus 0.0039 0.0009 0.01
Schistosoma mansoni hypothetical protein 0.0039 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Brugia malayi hypothetical protein 0.0039 0.0009 0.0009
Entamoeba histolytica tubulin gamma chain 0.0267 0.164 0.1136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0009 0.002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0001 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0009 0.002
Echinococcus multilocularis tubulin delta chain 0.0116 0.0558 0.1409
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0009 0.002
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0009 0.0008
Loa Loa (eye worm) TYRA-2 protein 0.0039 0.0009 0.0008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0009 0.0023
Echinococcus multilocularis Tubulin alpha 1 chain 0.032 0.2017 0.5103
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Trichomonas vaginalis tubulin, putative 0.059 0.3952 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Trichomonas vaginalis tubulin epsilon chain, putative 0.059 0.3952 1
Brugia malayi steroid hormone receptor 0.0038 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0039 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Echinococcus granulosus Tubulin beta 2C chain 0.059 0.3952 1
Echinococcus multilocularis g-protein coupled receptor 0.0039 0.0009 0.002
Trichomonas vaginalis tubulin gamma chain, putative 0.0267 0.164 0.3188
Leishmania major beta tubulin 0.059 0.3952 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0151 0.0809 0.0742
Echinococcus granulosus Tubulin alpha 1 chain 0.032 0.2017 0.5103
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0039 0.0009 0.0008
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Echinococcus granulosus tubulin alpha chain 0.032 0.2017 0.5103
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0226 0.1343 0.3398
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0009 0.002
Echinococcus granulosus tubulin delta chain 0.0116 0.0558 0.1409
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0151 0.0809 0.0742
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0226 0.1343 0.3193
Leishmania major beta tubulin 0.059 0.3952 1
Echinococcus multilocularis tubulin alpha chain 0.032 0.2017 0.5103
Echinococcus granulosus alpha tubulin 0.032 0.2017 0.5103
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0039 0.0009 0.002
Onchocerca volvulus 0.0039 0.0009 0.01
Echinococcus multilocularis Tubulin beta 2C chain 0.059 0.3952 1
Brugia malayi Tubulin alpha chain 0.032 0.2017 0.2017
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.012 0.0214
Loa Loa (eye worm) cytochrome P450 family protein 0.0212 0.1245 0.1245
Echinococcus multilocularis tubulin alpha 1C chain 0.032 0.2017 0.5103
Loa Loa (eye worm) hypothetical protein 0.0204 0.1187 0.1186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0009 0.0023
Brugia malayi Tachykinin-like peptides receptor 99D 0.0039 0.0009 0.0009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0009 0.002
Echinococcus granulosus peptide allatostatin:somatostatin 0.0039 0.0009 0.002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0009 0.0023
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0009 0.002
Trichomonas vaginalis tubulin beta chain, putative 0.0151 0.0809 0.0742
Loa Loa (eye worm) melatonin receptor type 1A 0.0039 0.0009 0.0008
Trichomonas vaginalis tubulin epsilon chain, putative 0.032 0.2017 0.43
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0039 0.0009 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0001 0.0001
Echinococcus multilocularis Tubulin beta 2C chain 0.059 0.3952 1
Schistosoma mansoni aldehyde dehydrogenase 0.0229 0.137 0.3466
Onchocerca volvulus 0.0039 0.0009 0.01
Leishmania major beta tubulin 0.059 0.3952 1
Echinococcus granulosus G protein coupled receptor 139 0.0039 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0226 0.1343 0.1343
Loa Loa (eye worm) tubulin beta chain 0.0116 0.0558 0.0557
Echinococcus granulosus tubulin alpha 0.0267 0.164 0.4148
Echinococcus granulosus neuropeptide s receptor 0.0039 0.0009 0.002
Echinococcus multilocularis Tubulin beta 2C chain 0.059 0.3952 1
Leishmania major beta tubulin 0.059 0.3952 1
Plasmodium falciparum alpha tubulin 1 0.032 0.2017 0.43
Loa Loa (eye worm) tubulin alpha 2 0.0053 0.0105 0.0104
Brugia malayi G protein-coupled receptor 0.0039 0.0009 0.0009
Onchocerca volvulus 0.0039 0.0009 0.01
Echinococcus granulosus tubulin subunit TubB 0.032 0.2017 0.5103
Echinococcus multilocularis somatostatin receptor 0.0039 0.0009 0.002
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0039 0.0009 0.002
Schistosoma mansoni biogenic amine receptor 0.0039 0.0009 0.0023
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0001 0.0002
Trichomonas vaginalis tubulin beta chain, putative 0.032 0.2017 0.43
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0009 0.002
Leishmania major alpha tubulin 0.032 0.2017 0.4952
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.005 0.0086 0.0127
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0009 0.002
Loa Loa (eye worm) alpha-tubulin 0.032 0.2017 0.2016
Echinococcus granulosus Tubulin alpha 1 chain 0.032 0.2017 0.5103
Loa Loa (eye worm) hypothetical protein 0.0128 0.0642 0.0641
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0009 0.002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0229 0.137 0.3465
Entamoeba histolytica tubulin family protein 0.059 0.3952 1
Schistosoma mansoni cytochrome P450 0.0111 0.0523 0.1324
Schistosoma mansoni hypothetical protein 0.0111 0.0523 0.1324
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Echinococcus multilocularis orexin receptor type 2 0.0039 0.0009 0.002
Echinococcus granulosus tubulin beta 1 chain 0.059 0.3952 1
Onchocerca volvulus 0.0151 0.0809 1
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0009 0.002
Schistosoma mansoni alpha tubulin 0.032 0.2017 0.5104
Brugia malayi Melatonin receptor type 1A 0.0039 0.0009 0.0009
Schistosoma mansoni tubulin subunit alpha 0.032 0.2017 0.5104
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0009 0.0023
Loa Loa (eye worm) tubulin alpha 2 0.0204 0.1187 0.1186
Trypanosoma brucei beta tubulin 0.059 0.3952 1
Giardia lamblia Beta tubulin 0.059 0.3952 1
Trichomonas vaginalis tubulin beta chain, putative 0.032 0.2017 0.43
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0009 0.0023
Trypanosoma cruzi tubulin delta chain 0.0116 0.0558 0.1333
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0001 0.0001
Schistosoma mansoni tubulin subunit beta 0.059 0.3952 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0001 0.0001
Echinococcus granulosus g protein coupled receptor 0.0039 0.0009 0.002
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.032 0.2017 0.43
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0001 0.0002
Loa Loa (eye worm) tubulin alpha-3 chain 0.0169 0.0935 0.0934
Loa Loa (eye worm) tubulin beta-1 chain 0.059 0.3952 0.3951
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0009 0.002
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0251 0.1522 0.1521
Brugia malayi beta-tubulin, identical 0.059 0.3952 0.3952
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0009 0.002
Loa Loa (eye worm) CYP4Cod1 0.0212 0.1245 0.1245
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0039 0.0009 0.0009
Echinococcus granulosus tubulin alpha chain 0.032 0.2017 0.5103
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0039 0.0009 0.0023
Brugia malayi hypothetical protein 0.0039 0.0009 0.0009
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0001 0.0002
Brugia malayi ORL1-like opioid receptor 0.0039 0.0009 0.0009
Echinococcus granulosus Tubulin beta 2C chain 0.059 0.3952 1
Plasmodium falciparum tubulin epsilon chain, putative 0.0267 0.164 0.3188
Loa Loa (eye worm) tubulin alpha chain 0.032 0.2017 0.2016
Echinococcus granulosus cytochrome P450 2K1 0.0111 0.0523 0.1322
Echinococcus multilocularis tubulin alpha 3 chain 0.032 0.2017 0.5103
Leishmania major beta tubulin 0.059 0.3952 1
Brugia malayi hypothetical protein 0.0039 0.0009 0.0009
Loa Loa (eye worm) tubulin alpha 2 0.0204 0.1187 0.1186
Schistosoma mansoni thyroid hormone receptor 0.016 0.0872 0.2207
Leishmania major alpha tubulin 0.032 0.2017 0.4952
Echinococcus granulosus fmrfamide receptor 0.0039 0.0009 0.002
Echinococcus multilocularis thyroid hormone receptor alpha 0.016 0.0872 0.2205
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0009 0.002
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0111 0.0523 0.1053
Trypanosoma brucei beta tubulin 0.059 0.3952 1
Brugia malayi Tubulin alpha chain 0.0116 0.0558 0.0558
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Onchocerca volvulus 0.0039 0.0009 0.01
Echinococcus granulosus neuropeptide FF receptor 2 0.0039 0.0009 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0009 0.0023
Trypanosoma cruzi zeta tubulin, putative 0.0116 0.0558 0.1333
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0009 0.002
Trypanosoma brucei zeta tubulin, putative 0.0116 0.0558 0.1143
Leishmania major beta tubulin 0.059 0.3952 1
Brugia malayi AKH receptor 0.0039 0.0009 0.0009
Leishmania major cytochrome p450-like protein 0.0111 0.0523 0.1053
Brugia malayi GnHR receptor homolog 0.0039 0.0009 0.0009
Leishmania major beta tubulin 0.059 0.3952 1
Echinococcus granulosus Tubulin beta 2C chain 0.059 0.3952 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0039 0.0009 0.002
Brugia malayi ecdysteroid receptor 0.0038 0.0001 0.0001
Loa Loa (eye worm) tubulin alpha-2 chain 0.032 0.2017 0.2016
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0001 0.0002
Leishmania major alpha tubulin 0.032 0.2017 0.4952
Schistosoma mansoni tubulin subunit alpha 0.032 0.2017 0.5104
Echinococcus granulosus neuropeptide receptor 0.0039 0.0009 0.002
Trichomonas vaginalis tubulin epsilon chain, putative 0.059 0.3952 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0009 0.002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0001 0.0002
Leishmania major alpha tubulin 0.032 0.2017 0.4952
Echinococcus granulosus survival motor neuron protein 1 0.0183 0.1042 0.2635
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0009 0.0008
Brugia malayi G protein-coupled receptor F59B2.13 0.0039 0.0009 0.0009
Giardia lamblia Gamma tubulin 0.0267 0.164 0.3188
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Leishmania major delta tubulin, putative 0.0116 0.0558 0.1143
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0039 0.0009 0.002
Trypanosoma brucei alpha tubulin 0.032 0.2017 0.4952
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0001 0.0002
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0009 0.002
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0009 0.002
Schistosoma mansoni alpha tubulin 0.032 0.2017 0.5104
Echinococcus granulosus sex peptide receptor 0.0039 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Brugia malayi Tubulin beta chain 0.0116 0.0558 0.0558
Trichomonas vaginalis tubulin, putative 0.0151 0.0809 0.0742
Trichomonas vaginalis tubulin alpha chain, putative 0.0151 0.0809 0.0742
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Echinococcus multilocularis tubulin subunit beta 0.059 0.3952 1
Schistosoma mansoni hypothetical protein 0.0039 0.0009 0.0023
Echinococcus multilocularis serotonin receptor 0.0039 0.0009 0.002
Trypanosoma brucei cytochrome P450, putative 0.0212 0.1245 0.2938
Leishmania major gamma-tubulin 0.0267 0.164 0.3966
Trichomonas vaginalis tubulin beta chain, putative 0.032 0.2017 0.43
Echinococcus multilocularis tubulin, beta 4A class IVa 0.059 0.3952 1
Echinococcus multilocularis hypothetical protein 0.032 0.2017 0.5103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0009 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.0251 0.1522 0.1522
Trypanosoma brucei beta tubulin 0.0267 0.164 0.3966
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0001 0.0002
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0039 0.0009 0.0023
Brugia malayi hypothetical protein 0.0039 0.0009 0.0009
Schistosoma mansoni amine GPCR 0.0039 0.0009 0.0023
Trypanosoma cruzi epsilon tubulin, putative 0.0267 0.164 0.4096
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0039 0.0009 0.002
Loa Loa (eye worm) hypoxia-induced factor 1 0.0118 0.0571 0.057
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0009 0.002
Brugia malayi cytochrome P450 0.0111 0.0523 0.0523
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0009 0.002
Leishmania major epsilon tubulin, putative 0.0267 0.164 0.3966
Brugia malayi putative neuropeptide receptor 0.0039 0.0009 0.0009
Schistosoma mansoni neuropeptide receptor 0.0039 0.0009 0.0023
Trypanosoma cruzi cytochrome P450, putative 0.0212 0.1245 0.3089
Echinococcus multilocularis tubulin alpha chain 0.032 0.2017 0.5103
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0039 0.0009 0.0023
Brugia malayi tubulin alpha chain - mouse 0.032 0.2017 0.2017
Toxoplasma gondii beta-1 tubulin, putative 0.059 0.3952 1
Echinococcus granulosus tubulin epsilon chain 0.0267 0.164 0.4148
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0039 0.0009 0.002
Leishmania major alpha tubulin 0.032 0.2017 0.4952
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0009 0.002
Brugia malayi larval opioid receptor 0.0039 0.0009 0.0009
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0599 0.1513
Brugia malayi hypoxia-induced factor 1 0.0118 0.0571 0.0571
Echinococcus multilocularis serotonin receptor 0.0039 0.0009 0.002
Brugia malayi alpha-tubulin 0.032 0.2017 0.2017
Brugia malayi Serotonin receptor 0.0039 0.0009 0.0009
Leishmania major beta tubulin 0.059 0.3952 1
Loa Loa (eye worm) tubulin gamma chain 0.0267 0.164 0.1639
Mycobacterium ulcerans aldehyde dehydrogenase 0.0229 0.137 1
Giardia lamblia Beta tubulin 0.059 0.3952 1
Schistosoma mansoni tubulin subunit beta 0.059 0.3952 1
Echinococcus multilocularis tubulin alpha 0.0267 0.164 0.4148
Brugia malayi hypothetical protein 0.0128 0.0642 0.0642
Loa Loa (eye worm) tubulin beta-4 chain 0.059 0.3952 0.3951
Leishmania major beta tubulin 0.059 0.3952 1
Schistosoma mansoni tubulin subunit beta 0.059 0.3952 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0229 0.137 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0226 0.1343 0.3398
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0039 0.0009 0.002
Echinococcus granulosus allatostatin A receptor 0.0039 0.0009 0.002
Brugia malayi hypothetical protein 0.0039 0.0009 0.0009
Leishmania major beta tubulin 0.059 0.3952 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0226 0.1343 0.3193
Brugia malayi G-protein coupled receptor 0.0039 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Mycobacterium ulcerans cell division protein FtsZ 0.0116 0.0558 0.0406
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Onchocerca volvulus 0.0039 0.0009 0.01
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0009 0.002
Brugia malayi Dopamine receptor protein 1 0.0039 0.0009 0.0009
Onchocerca volvulus 0.0039 0.0009 0.01
Echinococcus multilocularis neuropeptide FF receptor 2 0.0039 0.0009 0.002
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0111 0.0523 0.1245
Echinococcus granulosus tachykinin peptides receptor 99D 0.0039 0.0009 0.002
Trypanosoma cruzi beta tubulin, putative 0.059 0.3952 1
Trypanosoma cruzi cruzipain precursor, putative 0.0055 0.012 0.0214
Brugia malayi hypothetical protein 0.0039 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0116 0.0558 0.01
Brugia malayi Cytochrome P450 family protein 0.0213 0.1251 0.1251
Echinococcus granulosus beta tubulin 0.059 0.3952 1
Trichomonas vaginalis tubulin beta chain, putative 0.032 0.2017 0.43
Trichomonas vaginalis tubulin beta chain, putative 0.059 0.3952 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Schistosoma mansoni tubulin subunit alpha 0.0116 0.0558 0.1411
Leishmania major alpha tubulin 0.032 0.2017 0.4952
Echinococcus granulosus ubiquitin specific protease 41 0.0226 0.1343 0.3398
Giardia lamblia Alpha-tubulin 0.032 0.2017 0.43
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0039 0.0009 0.002
Trichomonas vaginalis tubulin gamma chain, putative 0.0267 0.164 0.3188
Leishmania major zeta tubulin, putative 0.0116 0.0558 0.1143
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0001 0.0001
Trypanosoma brucei beta tubulin 0.059 0.3952 1
Trypanosoma cruzi alpha tubulin, putative 0.032 0.2017 0.506
Brugia malayi RE15519p 0.0039 0.0009 0.0009
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0039 0.0009 0.01
Brugia malayi hypothetical protein 0.0039 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0248 0.1507 0.1506
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0009 0.002
Leishmania major cytochrome p450-like protein 0.0111 0.0523 0.1053
Schistosoma mansoni tubulin subunit epsilon 0.0267 0.164 0.4149
Plasmodium falciparum alpha tubulin 2 0.032 0.2017 0.43
Echinococcus granulosus tubulin beta 4A class IVa 0.059 0.3952 1
Brugia malayi sulfakinin receptor protein 0.0039 0.0009 0.0009
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0204 0.1187 0.1186
Entamoeba histolytica tubulin alpha chain, putative 0.032 0.2017 0.2583
Schistosoma mansoni aldehyde dehydrogenase 0.0229 0.137 0.3466
Echinococcus multilocularis tubulin alpha chain 0.032 0.2017 0.5103
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0229 0.137 1
Echinococcus multilocularis survival motor neuron protein 1 0.0183 0.1042 0.2635
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.012 0.0214
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Brugia malayi hypothetical protein 0.0039 0.0009 0.0009
Plasmodium vivax tubulin alpha chain, putative 0.032 0.2017 0.43
Echinococcus granulosus peroxisome assembly protein 26 0.032 0.2017 0.5103
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0009 0.002
Trypanosoma brucei epsilon tubulin 0.0267 0.164 0.3966
Trypanosoma brucei zeta tubulin 0.0116 0.0558 0.1143
Trichomonas vaginalis tubulin, putative 0.0151 0.0809 0.0742
Echinococcus granulosus somatostatin receptor 0.0039 0.0009 0.002
Echinococcus multilocularis neuropeptide receptor A26 0.0039 0.0009 0.002
Echinococcus multilocularis G protein coupled receptor 139 0.0039 0.0009 0.002
Echinococcus granulosus 7TM GPCR rhodopsin 0.0039 0.0009 0.002
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0169 0.0935 0.1112
Brugia malayi nuclear hormone receptor 0.0038 0.0001 0.0001
Echinococcus multilocularis tubulin alpha chain 0.032 0.2017 0.5103
Onchocerca volvulus 0.0039 0.0009 0.01
Echinococcus multilocularis Tubulin beta 2C chain 0.059 0.3952 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0226 0.1343 0.3398
Plasmodium falciparum tubulin gamma chain 0.0267 0.164 0.3188
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0226 0.1343 0.3399
Plasmodium vivax tubulin gamma chain, putative 0.0267 0.164 0.3188
Treponema pallidum cell division protein FtsZ 0.0116 0.0558 0.5
Echinococcus multilocularis Tubulin alpha 1 chain 0.032 0.2017 0.5103
Echinococcus granulosus Tubulin beta 2C chain 0.059 0.3952 1
Echinococcus granulosus tubulin subunit beta 0.059 0.3952 1
Schistosoma mansoni neuropeptide receptor 0.0039 0.0009 0.0023
Echinococcus multilocularis G-protein coupled receptor, putative 0.0039 0.0009 0.002
Echinococcus multilocularis 0.0111 0.0523 0.1322
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0599 0.1513
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0009 0.002

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Compound tested for in vitro antimicrobial activity against gram positive and gram negative bacteria; Active ChEMBL. 10937711
Activity (functional) 0 Antimicrobial activity against aspergillus sp and Candida albicans; Inactive ChEMBL. 10937711
MIC (functional) = 0.729 mg ml-1 Minimum inhibitory concentration against Bacillus subtilis ChEMBL. 10937711
MIC (functional) = 1.62 mg ml-1 Minimum inhibitory concentration against Micrococcus roseus ChEMBL. 10937711
MIC (functional) = 1.62 mg ml-1 Minimum inhibitory concentration against Staphylococcus aureus ChEMBL. 10937711
MIC (functional) = 1.62 mg ml-1 Minimum inhibitory concentration against Escherichia coli. ChEMBL. 10937711
MIC (functional) = 1.62 mg ml-1 Minimum inhibitory concentration against Escherichia coli. ChEMBL. 10937711
MIC (functional) = 3.6 mg ml-1 Minimum inhibitory concentration against Pseudomonas aeruginosa ChEMBL. 10937711

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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