TDR Targets

Basic information

Technical information

TDR Targets ID: 64789
Name: (Z)-N-(2,4,6-trimethoxyphenyl)octadec-9-eneth ioamide
MW: 463.716 | Formula: C27H45NO3S
H donors: 0 H acceptors: 0 LogP: 9.52 Rotable bonds: 19
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCC/C=C\CCCCCCC/C(=N/c1c(OC)cc(cc1OC)OC)/S
InChi: 1S/C27H45NO3S/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26(32)28-27-24(30-3)21-23(29-2)22-25(27)31-4/h12-13,21-22H,5-11,14-20H2,1-4H3,(H,28,32)/b13-12-
InChiKey: JRGHTLVAIOENFA-SEYXRHQNSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(Z)-N-(2,4,6-trimethoxyphenyl)-9-octadecenethioamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Oryctolagus cuniculus	Acyl-CoA:cholesterol acyltransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	sterol O acyltransferase 1	Get druggable targets OG5_133487	All targets in OG5_133487
Schistosoma japonicum	ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative	Get druggable targets OG5_133487	All targets in OG5_133487
Schistosoma mansoni	sterol O-acyltransferase 1	Get druggable targets OG5_133487	All targets in OG5_133487
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133487	All targets in OG5_133487
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133487	All targets in OG5_133487
Echinococcus granulosus	sterol O acyltransferase 1	Get druggable targets OG5_133487	All targets in OG5_133487

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Dictyostelium discoideum	diacylglycerol O-acyltransferase 1	Acyl-CoA:cholesterol acyltransferase	305 aa	278 aa	21.9 %
Neospora caninum	sterol O-acyltransferase, putative	Acyl-CoA:cholesterol acyltransferase	305 aa	258 aa	20.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0098	0.0098
Onchocerca volvulus		0.0241	0.1627	0.1627
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1627	0.1627
Leishmania major	glycerol uptake protein, putative	0.0026	0.0098	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0026	0.0099	0.0099
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0098	0.0098
Loa Loa (eye worm)	hhat protein	0.0026	0.0098	0.0098
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0014	0.0012	0.5
Echinococcus granulosus	sodium and chloride dependent glycine	0.0241	0.1627	0.1627
Schistosoma mansoni	nAChR subunit	0.0026	0.0099	0.0099
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0026	0.0098	0.0098
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0241	0.1627	0.1627
Schistosoma mansoni	nAChR subunit	0.0026	0.0099	0.0099
Schistosoma mansoni	hypothetical protein	0.0026	0.0098	0.0098
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0026	0.0099	0.0099
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0026	0.0099	0.0099
Onchocerca volvulus		0.0241	0.1627	0.1627
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0151	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0026	0.0098	0.0098
Schistosoma mansoni	hypothetical protein	0.0014	0.0012	0.0012
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0241	0.1627	0.1627
Brugia malayi	Cation transporter family protein	0.0026	0.0099	0.0099
Brugia malayi	cytochrome P450	0.0014	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.1422	1	1
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0026	0.0098	0.0531
Toxoplasma gondii	hypothetical protein	0.0241	0.1627	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0026	0.0099	0.0099
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0026	0.0098	0.0098
Trypanosoma cruzi	GUP1, putative	0.0026	0.0098	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0241	0.1627	0.1627
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0012	0.0012
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0026	0.0099	0.0099
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0026	0.0098	0.0098
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0098	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0241	0.1627	1
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1627	0.1627
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0098	0.0098
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0241	0.1627	0.1627
Loa Loa (eye worm)	cytochrome P450	0.0014	0.0012	0.0012
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0098	1
Loa Loa (eye worm)	CYP4Cod1	0.0022	0.0072	0.0072
Loa Loa (eye worm)	norepinephrine transporter	0.1422	1	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0014	0.0014	0.0014
Schistosoma mansoni	sodium/chloride dependent transporter	0.0241	0.1627	0.1627
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0098	1
Echinococcus granulosus	glycine receptor subunit beta	0.0026	0.0099	0.0099
Onchocerca volvulus		0.0026	0.0098	0.0098
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0098	1
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0026	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1627	0.1627
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1627	0.1627
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0026	0.0098	0.0098
Entamoeba histolytica	hypothetical protein	0.0026	0.0098	1
Echinococcus granulosus	glycine receptor subunit beta	0.0026	0.0099	0.0099
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0241	0.1627	0.1627
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0026	0.0098	0.0098
Schistosoma mansoni	nAChR subunit	0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0014	0.0014
Onchocerca volvulus		0.0026	0.0099	0.0099
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0026	0.0099	0.0099
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0241	0.1627	0.1627
Mycobacterium leprae	Conserved hypothetical protein	0.0014	0.0012	0.5
Leishmania major	glycerol uptake protein, putative	0.0026	0.0098	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0014	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0026	0.0098	0.0098
Echinococcus multilocularis		0.0014	0.0012	0.0012
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0026	0.0099	0.0099
Echinococcus granulosus	serotonin transporter	0.1422	1	1
Entamoeba histolytica	hypothetical protein, conserved	0.0026	0.0098	1
Echinococcus multilocularis	sterol O acyltransferase 1	0.0264	0.1787	0.1787
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0026	0.0099	0.0099
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0026	0.0099	0.0099
Brugia malayi	MBOAT family protein	0.0026	0.0098	0.0098
Plasmodium falciparum	amino acid transporter, putative	0.0241	0.1627	1
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0014	0.0012	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0014	0.0014	0.0014
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0026	0.0099	0.0099
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.1422	1	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0168	0.0168
Loa Loa (eye worm)	LGC-31 protein	0.0026	0.0099	0.0099
Plasmodium falciparum	transporter, putative	0.0241	0.1627	1
Loa Loa (eye worm)	ACC-1 protein	0.0026	0.0099	0.0099
Onchocerca volvulus		0.0026	0.0099	0.0099
Schistosoma mansoni	sterol O-acyltransferase 1	0.0264	0.1787	0.1787
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0241	0.1627	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Leishmania major	glycerol uptake protein, putative	0.0026	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Brugia malayi	excitatory GABA receptor EXP-1A	0.0026	0.0099	0.0099
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0014	0.0012	0.5
Echinococcus granulosus	nAChR subunit	0.0014	0.0014	0.0014
Brugia malayi	Hhat protein	0.0026	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0098	0.0098
Schistosoma mansoni	sodium/chloride dependent transporter	0.0241	0.1627	0.1627
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0026	0.0098	0.0098
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0026	0.0099	0.0099
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0026	0.0099	0.0099
Trypanosoma cruzi	cytochrome P450, putative	0.0022	0.0072	0.6996
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0072	0.0072
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0241	0.1627	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0098	0.0098
Leishmania major	hypothetical protein, conserved	0.0026	0.0098	1
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0026	0.0098	0.0098
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0241	0.1627	0.1627
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0026	0.0099	0.0099
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0026	0.0099	0.0099
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0191	0.0191
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0026	0.0099	0.0099
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.0072	0.0072
Toxoplasma gondii	hypothetical protein	0.0241	0.1627	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0241	0.1627	0.1627
Trypanosoma brucei	glycerol uptake protein, putative	0.0026	0.0098	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0026	0.0099	0.0099
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0026	0.0098	0.0098
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0098	0.0098
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0026	0.0099	0.0099
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0098	0.0098
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0134	0.0134
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0241	0.1627	0.1627
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0026	0.0099	0.0099
Echinococcus multilocularis	nAChR subunit	0.0014	0.0014	0.0014
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0026	0.0099	0.0099
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0168	0.0168
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0014	0.0012	0.5
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0241	0.1627	0.1627
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0026	0.0099	0.0099
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0014	0.0012	0.5
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0026	0.0099	0.0099
Echinococcus granulosus	sodium and chloride dependent glycine	0.0241	0.1627	0.1627
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0014	0.0014
Loa Loa (eye worm)	cytochrome P450 family protein	0.0051	0.0274	0.0274
Trypanosoma cruzi	cytochrome P450, putative	0.0022	0.0072	0.6996
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0014	0.0012	0.5
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0026	0.0099	0.0099
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0014	0.0012	0.5
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1627	0.1627
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0026	0.0098	0.0098
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0014	0.0012	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0014	0.0014
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0014	0.0014
Brugia malayi	MBOAT family protein	0.0026	0.0098	0.0098
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0026	0.0099	0.0099
Onchocerca volvulus		0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.1422	1	1
Schistosoma mansoni	nAChR subunit	0.0026	0.0099	0.0099
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0098	0.0098
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0014	0.0014	0.0014
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0026	0.0099	0.0099
Leishmania major	glycerol uptake protein, putative	0.0026	0.0098	1
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0014	0.0012	0.5
Onchocerca volvulus		0.0014	0.0014	0.0014
Mycobacterium leprae	putative cytochrome p450	0.0014	0.0012	0.5
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1627	0.1627
Schistosoma mansoni	nAChR subunit	0.0026	0.0099	0.0099
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0026	0.0098	0.0098
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0168	0.0168
Loa Loa (eye worm)	hhat protein	0.0026	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0014	0.0014
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0241	0.1627	0.1627
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0014	0.0012	0.5
Brugia malayi	hypothetical protein	0.0241	0.1627	0.1627
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0026	0.0098	0.0531
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0241	0.1627	0.1627
Loa Loa (eye worm)	hypothetical protein	0.0264	0.1787	0.1787
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0241	0.1627	0.1627
Echinococcus granulosus	nAChR subunit	0.0026	0.0099	0.0099
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0026	0.0099	0.0099
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0241	0.1627	0.5
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0098	0.0098
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0026	0.0099	0.0099
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0014	0.0012	0.5
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0022	0.0072	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1604	0.1604
Echinococcus granulosus	sterol O acyltransferase 1	0.0264	0.1787	0.1787
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0026	0.0099	0.0099
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0026	0.0099	0.0099
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0026	0.0099	0.0099
Schistosoma mansoni	neurotransmitter gated ion channel	0.0014	0.0014	0.0014
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0014	0.0012	0.5
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0098	0.0098
Echinococcus multilocularis	glycine receptor subunit beta	0.0026	0.0099	0.0099
Schistosoma mansoni	cytochrome P450	0.0014	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0014	0.0014
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0098	1
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0026	0.0099	0.0099
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0026	0.0099	0.0099
Onchocerca volvulus		0.0026	0.0099	0.0099
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0241	0.1627	0.1627
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0014	0.0014
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0098	0.0098
Plasmodium vivax	hypothetical protein, conserved	0.0241	0.1627	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Brugia malayi	MBOAT family protein	0.0026	0.0098	0.0098
Brugia malayi	Cytochrome P450 family protein	0.0051	0.0274	0.0274
Leishmania major	cytochrome p450-like protein	0.0022	0.0072	0.6996
Brugia malayi	MBOAT family protein	0.0026	0.0098	0.0098
Onchocerca volvulus		0.0026	0.0099	0.0099
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0014	0.0014	0.0014
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0241	0.1627	0.1627
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0151	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0026	0.0099	0.0099
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0241	0.1627	0.1627
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0072	0.0072
Brugia malayi	MBOAT family protein	0.0026	0.0098	0.0098
Onchocerca volvulus	Putative nachr subunit	0.0026	0.0099	0.0099
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0241	0.1627	0.1627
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0026	0.0099	0.0099
Echinococcus multilocularis	glycine receptor subunit beta	0.0026	0.0099	0.0099
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.0072	0.0072
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0098	0.0098
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0026	0.0099	0.0099
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0014	0.0012	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0014	0.0014
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0014	0.0012	0.5
Leishmania major	glycerol uptake protein, putative	0.0026	0.0098	1
Brugia malayi	Cation transporter family protein	0.0026	0.0099	0.0099
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0026	0.0099	0.0099
Trypanosoma brucei	cytochrome P450, putative	0.0022	0.0072	0.6996
Echinococcus multilocularis	nAChR subunit	0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0241	0.1627	0.1627
Trypanosoma brucei	glycerol uptake protein, putative	0.0026	0.0098	1
Echinococcus multilocularis	serotonin transporter	0.1422	1	1
Entamoeba histolytica	vacuolar protein sorting 26	0.0026	0.0098	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0241	0.1627	0.1627
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0014	0.0012	0.5
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0026	0.0098	0.0098
Schistosoma mansoni	zinc finger protein	0.0026	0.0098	0.0098
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0026	0.0099	0.0099
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0026	0.0099	0.0099
Plasmodium vivax	amine transporter, putative	0.0241	0.1627	1
Trypanosoma cruzi	GUP1, putative	0.0026	0.0098	1
Onchocerca volvulus		0.0014	0.0014	0.0014
Onchocerca volvulus		0.1422	1	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0241	0.1627	0.1627
Brugia malayi	Cation transporter family protein	0.0026	0.0099	0.0099
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0014	0.0014	0.0014
Loa Loa (eye worm)	GABA receptor subunit	0.0014	0.0014	0.0014
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0241	0.1627	0.1627
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0098	0.0098
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0014	0.0012	0.5
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0026	0.0098	0.0098
Echinococcus granulosus	cytochrome P450 2K1	0.0014	0.0012	0.0012
Schistosoma mansoni	sodium/chloride dependent transporter	0.1422	1	1
Loa Loa (eye worm)	serotonin transporter b	0.1422	1	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0026	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0014	0.0012	0.5
Schistosoma mansoni	nAChR subunit	0.0026	0.0099	0.0099
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0241	0.1627	0.1627
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0241	0.1627	0.1627
Loa Loa (eye worm)	solute carrier family 6 member 4	0.1422	1	1
Loa Loa (eye worm)	ACC-1 protein	0.0026	0.0099	0.0099
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0026	0.0099	0.0099
Schistosoma mansoni	nAChR subunit	0.0026	0.0099	0.0099
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0241	0.1627	0.1627
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1422	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0098	0.0098
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0026	0.0099	0.0099
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0014	0.0012	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0099	0.0099
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0241	0.1627	0.1627
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0014	0.0012	0.5
Toxoplasma gondii	hypothetical protein	0.0026	0.0098	0.0531
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0014	0.0012	0.5
Onchocerca volvulus		0.0241	0.1627	0.1627
Onchocerca volvulus		0.0026	0.0099	0.0099
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0026	0.0099	0.0099
Brugia malayi	diacylglycerol acyltransferase	0.0026	0.0098	0.0098
Treponema pallidum	sodium- and chloride- dependent transporter	0.1422	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Change (functional)	= -22 %	In vivo change in plasma total cholesterol in cholic acid(0.3%)-cholesterol(1.5%)-peanut oil(5.5%) fed rats dosed at 0.05% of diet.	ChEMBL.	8496932
Change (functional)	= -22 %	In vivo change in plasma total cholesterol in cholic acid(0.3%)-cholesterol(1.5%)-peanut oil(5.5%) fed rats dosed at 0.05% of diet.	ChEMBL.	8496932
IC50 (binding)	= 0.9 uM	Acyl coenzyme A:cholesterol acyltransferase (ACAT), inhibition by incubation with [1-14C]-oleolyl-CoA and intestinal microsomes isolated from intestinal mucosa of cholesterol-fed rabbits	ChEMBL.	8496932
IC50 (binding)	= 0.9 uM	Acyl coenzyme A:cholesterol acyltransferase (ACAT), inhibition by incubation with [1-14C]-oleolyl-CoA and intestinal microsomes isolated from intestinal mucosa of cholesterol-fed rabbits	ChEMBL.	8496932

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL416626
PubChem: 10027416

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 64789