Detailed information for compound 651539

Basic information

Technical information
  • TDR Targets ID: 651539
  • Name: ethyl 2-(2H-tetrazol-5-yl)acetate
  • MW: 156.143 | Formula: C5H8N4O2
  • H donors: 1 H acceptors: 4 LogP: -0.34 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)Cc1n[nH]nn1
  • InChi: 1S/C5H8N4O2/c1-2-11-5(10)3-4-6-8-9-7-4/h2-3H2,1H3,(H,6,7,8,9)
  • InChiKey: NAOHMNNTUFFTBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2H-tetrazol-5-yl)acetic acid ethyl ester
  • ethyl 2-(2H-1,2,3,4-tetrazol-5-yl)ethanoate
  • ZERO/001460
  • MLS001018103
  • SMR000354343
  • Ethyl 1H-tetrazole-5-acetate
  • 1H-Tetrazole-5-acetic acid, ethyl ester
  • Maybridge1_007787
  • SR-01000638817-1
  • EU-0067521
  • TimTec1_002720
  • 436917_ALDRICH
  • Acetic acid, 2-(5H-tetrazol-1-yl)-, ethyl ester
  • SEW 05162

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.022 0.0374
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0371 0.0404
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.0051 0.0051
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0056 0.0767 0.958
Loa Loa (eye worm) pyruvate kinase 0.0058 0.0801 0.1651
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0051 0.0073
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0447 0.4483
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0166 0.0239
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0017 0.0104 0.0104
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.0051 0.0073
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0032 0.0353 0.387
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0017 0.0104 0.0466
Echinococcus multilocularis zinc finger protein 0.0022 0.0187 0.0187
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0166 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0166 0.0342
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0015 0.0068 0.0068
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0023 0.0207 0.0207
Echinococcus granulosus pyruvate kinase 0.0058 0.0801 0.0801
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0371 0.0371
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0021 0.0177 0.0253
Brugia malayi ORL1-like opioid receptor 0.0014 0.0051 0.0106
Trypanosoma brucei glucose transporter 2A 0.0033 0.0378 0.4213
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0125 0.0075
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.005 0.0663 0.0663
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0108 0.0102
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Onchocerca volvulus 0.0015 0.007 0.0039
Plasmodium falciparum proline--tRNA ligase 0.0038 0.045 0.051
Onchocerca volvulus 0.0037 0.0447 0.0824
Entamoeba histolytica hypothetical protein 0.0024 0.022 0.1675
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0371 0.0371
Schistosoma mansoni transient receptor potential channel 0.0066 0.0939 0.1342
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0166 0.0166
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0371 0.0371
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0166 0.0237
Brugia malayi nuclear receptor NHR-88 0.0021 0.0166 0.0342
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0019 0.0143 0.0468
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0359 0.1855
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0017 0.0104 0.0104
Echinococcus granulosus sex peptide receptor 0.0014 0.0051 0.0051
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.022 0.2682
Loa Loa (eye worm) hypothetical protein 0.0046 0.0592 0.1221
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0231 0.0476
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.0051 0.0106
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0231 0.2819
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0051 0.0051
Brugia malayi isocitrate dehydrogenase 0.0016 0.0092 0.0189
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0378 0.4213
Schistosoma mansoni biogenic amine receptor 0.0014 0.0051 0.0073
Brugia malayi hypothetical protein 0.0014 0.0051 0.0106
Schistosoma mansoni transient receptor potential channel 4 0.01 0.1504 0.215
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.0051 0.0073
Echinococcus multilocularis neuropeptide receptor A26 0.0014 0.0051 0.0051
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0046 0.0596 0.7104
Trypanosoma brucei glucose transporter, putative 0.0033 0.0378 0.4213
Echinococcus granulosus pyruvate kinase 0.003 0.0321 0.0321
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0025 0.0244 1
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0336 0.0336
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0447 0.5155
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.007 0.0144
Brugia malayi hypothetical protein 0.0014 0.0051 0.0106
Schistosoma mansoni amine GPCR 0.0014 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus granulosus vesicular acetylcholine transporter 0.0297 0.4849 0.4849
Trichomonas vaginalis esterase, putative 0.0037 0.0447 0.2414
Toxoplasma gondii sugar transporter ST2 0.0015 0.007 0.0068
Onchocerca volvulus Pyruvate kinase homolog 0.0058 0.0801 0.1562
Loa Loa (eye worm) DEAH box polypeptide 35 0.0018 0.0125 0.0258
Mycobacterium tuberculosis Conserved protein 0.0037 0.0447 0.0996
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Brugia malayi Bromodomain containing protein 0.0079 0.116 0.2392
Echinococcus multilocularis pyruvate kinase 0.0046 0.0593 0.0593
Trypanosoma brucei ISWI complex protein 0.0016 0.0083 0.0181
Entamoeba histolytica hypothetical protein 0.0046 0.0596 0.7104
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.0051 0.0073
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0019 0.0143 0.0564
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0092 0.0131
Schistosoma mansoni opsin-like receptor 0.0014 0.0051 0.0073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0166 0.0166
Plasmodium falciparum pyruvate kinase 0.0058 0.0801 0.0981
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0017 0.0104 0.0466
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0173 0.2749 0.3595
Schistosoma mansoni opsin-like receptor 0.0014 0.0051 0.0073
Brugia malayi Pyruvate kinase, M2 isozyme 0.0058 0.0801 0.1651
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.004 0.0488 0.1007
Trichomonas vaginalis pyruvate kinase, putative 0.0058 0.0801 0.4683
Brugia malayi CXXC zinc finger family protein 0.003 0.0319 0.0657
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.075 0.1072
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.0051 0.0073
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0231 0.2819
Onchocerca volvulus 0.0015 0.007 0.0039
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0231 0.0425
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0092 0.0301
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0122 0.0719
Toxoplasma gondii sugar transporter ST1 0.0015 0.007 0.0068
Loa Loa (eye worm) hypothetical protein 0.0021 0.0166 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.1631 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.0051 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0447 0.2414
Brugia malayi ecdysteroid receptor 0.0021 0.0166 0.0342
Schistosoma mansoni glucose transporter 0.0015 0.007 0.01
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0371 0.0404
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0166 0.0237
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0371 0.0764
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.0051 0.0051
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.1631 0.1631
Brugia malayi AKH receptor 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0018 0.0114 0.0602
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0108 0.0102
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.075 0.1546
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0092 0.0092
Trypanosoma brucei glucose transporter, putative 0.0033 0.0378 0.4213
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.0051 0.0073
Echinococcus granulosus serotonin receptor 0.0014 0.0051 0.0051
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0092 0.003
Brugia malayi hypothetical protein 0.0014 0.0051 0.0106
Mycobacterium ulcerans sugar transporter 0.0015 0.007 0.0792
Brugia malayi neuropeptide F receptor 0.0014 0.0051 0.0106
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0447 0.0921
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.0796 0.1642
Loa Loa (eye worm) hypothetical protein 0.0032 0.0359 0.0741
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.0051 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0051 0.0073
Plasmodium falciparum protein kinase 6 0.0455 0.7523 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0166 0.0342
Brugia malayi Dopamine receptor 0.0014 0.0051 0.0106
Echinococcus granulosus voltage dependent calcium channel 0.005 0.0663 0.0663
Schistosoma mansoni protein kinase 0.0033 0.0371 0.053
Echinococcus granulosus nmda type glutamate receptor 0.011 0.168 0.168
Schistosoma mansoni neuropeptide receptor 0.0083 0.1226 0.1753
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.0051 0.0073
Loa Loa (eye worm) voltage-dependent calcium channel 0.0013 0.0036 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0125 0.0259
Loa Loa (eye worm) hypothetical protein 0.0037 0.0447 0.0921
Plasmodium falciparum mitogen-activated protein kinase 2 0.0173 0.2749 0.3595
Trypanosoma brucei glucose transporter, putative 0.0033 0.0378 0.4213
Onchocerca volvulus 0.0015 0.007 0.0039
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0092 0.003
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0378 0.4213
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0166 0.0342
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0051 0.0051
Schistosoma mansoni protein kinase 0.0033 0.0371 0.053
Loa Loa (eye worm) hypothetical protein 0.0058 0.0801 0.1651
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0019 0.0143 0.0204
Onchocerca volvulus 0.0025 0.0231 0.0374
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.1631 0.1631
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0119
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0359 0.0514
Schistosoma mansoni neuropeptide receptor 0.0014 0.0051 0.0073
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0166 0.0239
Schistosoma mansoni pyruvate kinase 0.0058 0.0801 0.1145
Plasmodium falciparum protein kinase 7 0.0303 0.4946 0.6542
Brugia malayi major facilitator superfamily protein 0.0015 0.007 0.0144
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0378 0.4213
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0015 0.0068 0.0068
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0026 0.025 0.2109
Plasmodium vivax hexose transporter 0.0107 0.1631 0.2094
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0125 0.0075
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus multilocularis transient receptor potential ion channel A 0.0095 0.1429 0.1429
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Schistosoma mansoni hypothetical protein 0.0035 0.0413 0.059
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.0051 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0371 0.053
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0371 0.0764
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0371 0.4115
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.1504 0.1504
Leishmania major glucose transporter, lmgt2 0.0033 0.0378 0.4213
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Trypanosoma cruzi ISWI complex protein 0.0016 0.0083 0.0181
Onchocerca volvulus 0.0015 0.007 0.0039
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0371 0.0404
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.0051 0.0051
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0371 0.0682
Schistosoma mansoni neuropeptide receptor 0.0014 0.0051 0.0073
Mycobacterium ulcerans lipase LipD 0.0037 0.0447 0.5539
Echinococcus granulosus solute carrier family 22 0.0015 0.007 0.007
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0092 0.0301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0092 0.0113
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Loa Loa (eye worm) hypothetical protein 0.0025 0.0231 0.0476
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0371 0.0371
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.007 0.0144
Brugia malayi G-protein coupled receptor 0.0014 0.0051 0.0106
Echinococcus multilocularis allatostatin A receptor 0.0014 0.0051 0.0051
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0177 0.0364
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0445 0.0445
Echinococcus granulosus solute carrier family 22 0.0015 0.007 0.007
Schistosoma mansoni histamine h1 receptor 0.0014 0.0051 0.0073
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0166 0.0342
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Brugia malayi pyruvate kinase, muscle isozyme 0.0012 0.0022 0.0046
Echinococcus multilocularis serotonin receptor 0.0014 0.0051 0.0051
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.007 0.0144
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0166 0.0237
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.075 0.1546
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0092 0.0113
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0447 0.2414
Onchocerca volvulus 0.0015 0.007 0.0039
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0051 0.0051
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0378 0.1973
Onchocerca volvulus Pyruvate kinase homolog 0.0058 0.0801 0.1562
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0371 0.0371
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.045 0.0842
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0051 0.0073
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.017 0.0641
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0153
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0025 0.0244 0.0461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0108 0.0102
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.0051 0.0051
Schistosoma mansoni amine GPCR 0.0014 0.0051 0.0073
Plasmodium vivax pyruvate kinase, putative 0.0058 0.0801 0.0981
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.0051 0.0106
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.0051 0.0051
Echinococcus granulosus pyruvate kinase 0.003 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0166 0.0342
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.3853 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0359 0.0741
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Schistosoma mansoni voltage-gated cation channel 0.005 0.0663 0.0948
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0131
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0017 0.0104 0.0466
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.075 0.075
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0231 0.2201
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0166 0.0166
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0447 0.5539
Mycobacterium ulcerans beta-lactamase 0.0037 0.0447 0.5539
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.1631 0.1631
Onchocerca volvulus 0.0015 0.007 0.0039
Schistosoma mansoni pyruvate kinase 0.003 0.0321 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0091 0.0091
Brugia malayi Sugar transporter family protein 0.0015 0.007 0.0144
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0051 0.0073
Onchocerca volvulus 0.0015 0.007 0.0039
Echinococcus multilocularis orexin receptor type 2 0.0014 0.0051 0.0051
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0051 0.0106
Brugia malayi beta-lactamase family protein 0.0037 0.0447 0.0921
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0104 0.0218
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0051 0.0073
Onchocerca volvulus 0.0015 0.007 0.0039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0108 0.0102
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0131
Echinococcus granulosus glutamate receptor NMDA 0.0105 0.1595 0.1595
Brugia malayi Serotonin receptor 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0051 0.0106
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0378 0.1973
Onchocerca volvulus 0.0015 0.007 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0051 0.0073
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Schistosoma mansoni hypothetical protein 0.0176 0.2789 0.3987
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.0051 0.0051
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0447 0.0996
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0038 0.045 0.045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0884 0.1264
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0359 0.0514
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0166 0.0166
Leishmania major hypothetical protein, conserved 0.0037 0.0447 0.5155
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0051 0.0679 0.1401
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0143 0.0295
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0038 0.045 0.045
Mycobacterium ulcerans pyruvate kinase 0.0058 0.0801 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.007 0.0792
Brugia malayi Cam kinase protein 1 0.0033 0.0371 0.0764
Loa Loa (eye worm) calcium channel 0.005 0.0663 0.1368
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0939 0.0939
Brugia malayi G protein-coupled receptor 0.0014 0.0051 0.0106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0166 0.0166
Trypanosoma brucei pyruvate kinase 1, putative 0.0058 0.0801 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0166 0.0166
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Schistosoma mansoni neuropeptide receptor 0.0014 0.0051 0.0073
Brugia malayi follicle stimulating hormone receptor 0.0014 0.0051 0.0106
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.045 0.5196
Brugia malayi Sugar transporter family protein 0.0015 0.007 0.0144
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.022 0.022
Echinococcus multilocularis solute carrier family 22 0.0015 0.007 0.007
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0371 0.0404
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0035 0.0412 0.0412
Leishmania major glucose transporter, lmgt1 0.0033 0.0378 0.4213
Loa Loa (eye worm) pyruvate kinase 0.0058 0.0801 0.1651
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0091 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0166 0.0342
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0159 0.0235
Schistosoma mansoni protein kinase 0.0033 0.0371 0.053
Loa Loa (eye worm) hypothetical protein 0.0025 0.0231 0.0476
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0051 0.0106
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus multilocularis pyruvate kinase 0.003 0.0321 0.0321
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0051 0.0051
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.0051 0.0051
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0125 0.1493
Leishmania major pyruvate kinase 0.0058 0.0801 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.0051 0.0106
Schistosoma mansoni sugar transporter 0.0015 0.007 0.01
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0231 0.2819
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0231 0.0476
Loa Loa (eye worm) hypothetical protein 0.0042 0.053 0.1092
Brugia malayi hypothetical protein 0.0014 0.0051 0.0106
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0371 0.0682
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0378 0.4213
Mycobacterium leprae Probable lipase LipE 0.0037 0.0447 0.4483
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0371 0.0404
Echinococcus multilocularis solute carrier family 22 0.0015 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus granulosus solute carrier family 22 0.0015 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0166 0.0342
Onchocerca volvulus 0.0037 0.0447 0.0824
Schistosoma mansoni glutamate receptor NMDA 0.012 0.1848 0.2642
Onchocerca volvulus 0.0015 0.007 0.0039
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.0051 0.0073
Brugia malayi PHD-finger family protein 0.0028 0.028 0.0578
Schistosoma mansoni glucose transport protein 0.0107 0.1631 0.2331
Echinococcus multilocularis nmda type glutamate receptor 0.014 0.2192 0.2192
Entamoeba histolytica hypothetical protein 0.0037 0.0433 0.4758
Plasmodium falciparum hexose transporter 0.0107 0.1631 0.2094
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus granulosus g protein coupled receptor 0.0014 0.0051 0.0051
Schistosoma mansoni amine GPCR 0.0014 0.0051 0.0073
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0032 0.0353 0.387
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0002 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Brugia malayi hypothetical protein 0.0037 0.0433 0.0894
Loa Loa (eye worm) hypothetical protein 0.0073 0.1056 0.2178
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0166 0.0342
Plasmodium vivax CDK-related protein kinase 6, putative 0.0455 0.7523 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0378 0.1973
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Trypanosoma brucei glucose transporter, putative 0.0033 0.0378 0.4213
Brugia malayi beta-lactamase family protein 0.0037 0.0447 0.0921
Leishmania major protein kinase, putative 0.0033 0.0371 0.4115
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0433 0.0619
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0024 0.022 0.0453
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0021 0.0166 0.0342
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.022 0.2323
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0051 0.0051
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.022 0.2053
Schistosoma mansoni biogenic amine receptor 0.0014 0.0051 0.0073
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0051 0.0051
Brugia malayi Sugar transporter family protein 0.0107 0.1631 0.3363
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.005 0.0663 0.0948
Loa Loa (eye worm) hypothetical protein 0.0016 0.0091 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0166 0.0342
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus granulosus neuropeptide receptor 0.0014 0.0051 0.0051
Onchocerca volvulus 0.0015 0.007 0.0039
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.1631 0.1631
Loa Loa (eye worm) pyruvate kinase 0.0012 0.0022 0.0046
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.007 0.0068
Schistosoma mansoni transient receptor potential channel 0.01 0.1504 0.215
Loa Loa (eye worm) hypothetical protein 0.0037 0.0447 0.0921
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.075 0.075
Brugia malayi hypothetical protein 0.0014 0.0051 0.0106
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0091 0.0188
Brugia malayi hypothetical protein 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0052 0.069 0.1422
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0166 0.0166
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.005 0.0663 0.0663
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0166 0.0237
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0092 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0166 0.0342
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.004 0.0489 0.2685
Echinococcus multilocularis pyruvate kinase 0.003 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0041 0.0502 0.1036
Mycobacterium tuberculosis Conserved protein 0.0037 0.0447 0.0996
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0359 0.0741
Schistosoma mansoni biogenic amine receptor 0.0014 0.0051 0.0073
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0166 0.0237
Trypanosoma brucei glucose transporter, putative 0.0033 0.0378 0.4213
Trypanosoma cruzi ISWI complex protein 0.0016 0.0083 0.0181
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0811 0.1579
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0051 0.0073
Echinococcus multilocularis GPCR, family 2 0.0016 0.0091 0.0091
Brugia malayi Bromodomain containing protein 0.004 0.0487 0.1004
Onchocerca volvulus 0.003 0.0319 0.0557
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0051 0.0073
Brugia malayi G-protein coupled receptor 0.0014 0.0051 0.0106
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0143 0.1
Onchocerca volvulus 0.0021 0.0166 0.0239
Schistosoma mansoni zinc finger protein 0.0022 0.0187 0.0267
Mycobacterium leprae Probable pyruvate kinase PykA 0.0058 0.0801 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0166 0.0342
Schistosoma mansoni cpg binding protein 0.003 0.0319 0.0455
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0051 0.0051
Onchocerca volvulus Putative transporter 0.0015 0.007 0.0039
Echinococcus granulosus solute carrier family 22 0.0015 0.007 0.007
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0051 0.0073
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0447 0.0921
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0125 0.0178
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0092 0.0092
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0359 0.0359
Giardia lamblia Pyruvate kinase 0.003 0.0321 0.3655
Trypanosoma brucei pyruvate kinase 1 0.0058 0.0801 1
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0025 0.0244 0.2989
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0166 0.0342
Schistosoma mansoni bromodomain containing protein 0.0067 0.0954 0.1364
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.1631 0.1631
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0114 0.0235
Loa Loa (eye worm) hypothetical protein 0.0026 0.0257 0.053
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.045 0.5196
Schistosoma mansoni hypothetical protein 0.0424 0.6995 1
Brugia malayi hypothetical protein 0.0015 0.007 0.0144
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0231 0.2819
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0074 0.0074
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0166 0.0237
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0018 0.0125 0.0257
Brugia malayi Melatonin receptor type 1A 0.0014 0.0051 0.0106
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0447 0.0996
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0051 0.0051
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0447 0.0996
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0051 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Echinococcus multilocularis pyruvate kinase 0.003 0.0321 0.0321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0051 0.0073
Echinococcus granulosus General substrate transporter 0.0092 0.1375 0.1375
Brugia malayi Pyruvate kinase, muscle isozyme 0.0058 0.0801 0.1651
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0359 0.0359
Echinococcus granulosus nmda type glutamate receptor 0.014 0.2192 0.2192
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0447 0.5539
Brugia malayi lysyl-tRNA synthetase 0.0024 0.022 0.0453
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0433 0.0433
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0447 0.2414
Echinococcus multilocularis voltage dependent calcium channel 0.005 0.0663 0.0663
Schistosoma mansoni hypothetical protein 0.0176 0.2789 0.3987
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0125 0.1493
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0447 0.0996
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.0051 0.0051
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0038 0.0079
Schistosoma mansoni sugar transporter 0.0015 0.007 0.01
Plasmodium vivax pyruvate kinase 2, putative 0.003 0.0321 0.0337
Brugia malayi Dopamine receptor protein 2 0.0014 0.0051 0.0106
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0166 0.0166
Echinococcus multilocularis pyruvate kinase 0.0058 0.0801 0.0801
Echinococcus granulosus allatostatin A receptor 0.0014 0.0051 0.0051
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.022 0.0201
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.0051 0.0106
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0166 0.0342
Brugia malayi larval opioid receptor 0.0014 0.0051 0.0106
Brugia malayi GnHR receptor homolog 0.0014 0.0051 0.0106
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0433 0.0433
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.0051 0.0051
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.005 0.0663 0.0663
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0378 0.4213
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.069 0.1422
Echinococcus granulosus g-protein coupled receptor 0.0014 0.0051 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0166 0.0342
Giardia lamblia Pyruvate kinase 0.0058 0.0801 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0159 0.0235
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.022 0.0961
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0378 0.1973
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0051 0.0051
Echinococcus granulosus GPCR family 2 0.0016 0.0091 0.0091
Brugia malayi RE15519p 0.0014 0.0051 0.0106
Schistosoma mansoni hypothetical protein 0.0014 0.0051 0.0073
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.007 0.5
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0359 0.4167
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.0051 0.0051
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0371 0.0404
Toxoplasma gondii pyruvate kinase PyK1 0.0058 0.0801 0.1557
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0051 0.0073
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0051 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0058 0.0796 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0092 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0166 0.0342
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.0051 0.0051
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0166 0.0166
Schistosoma mansoni amine GPCR 0.0014 0.0051 0.0073
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0019 0.0143 0.1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0231 0.2819
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.1631 0.1631
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0125 0.0259
Loa Loa (eye worm) beta-lactamase 0.0037 0.0447 0.0921
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.0051 0.0051
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0019 0.0143 0.0468
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.004 0.0489 0.2685
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0092 0.0301
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0231 0.2819
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0297 0.4849 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0166 0.0342
Loa Loa (eye worm) hypothetical protein 0.0037 0.0447 0.0921
Echinococcus granulosus hypothetical protein 0.0014 0.0051 0.0051
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0015 0.0068 0.0068
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0109 0.1661 0.1661
Loa Loa (eye worm) hypothetical protein 0.01 0.1504 0.3102
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0018 0.0125 0.0259
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.005 0.0663 0.0948
Toxoplasma gondii protein kinase, putative 0.0303 0.4946 1
Echinococcus granulosus fmrfamide receptor 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0447 0.0638
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0939 0.0939
Loa Loa (eye worm) hypothetical protein 0.0033 0.0371 0.0764
Entamoeba histolytica hypothetical protein 0.0037 0.0433 0.4758
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0075
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0051 0.0051
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0114 0.0163
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0068 0.0068
Giardia lamblia Sugar-proton symporter 0.0015 0.007 0.034
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.005 0.0663 0.0663
Schistosoma mansoni glucose transport protein 0.0107 0.1631 0.2331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0051 0.0073
Entamoeba histolytica hypothetical protein 0.0037 0.0433 0.4758
Schistosoma mansoni cpg binding protein 0.0033 0.0381 0.0544
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0378 0.1973
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0166 0.0342
Schistosoma mansoni adenoreceptor 0.0014 0.0051 0.0073
Echinococcus granulosus neuropeptide receptor 0.0083 0.1226 0.1226
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0166 0.0342
Echinococcus multilocularis solute carrier family 22 0.0015 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0074 0.0851
Loa Loa (eye worm) hypothetical protein 0.0038 0.045 0.0929
Echinococcus multilocularis neuropeptide s receptor 0.0014 0.0051 0.0051
Echinococcus granulosus neuropeptide s receptor 0.0014 0.0051 0.0051
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.005 0.0663 0.0663
Brugia malayi major facilitator superfamily protein 0.0015 0.007 0.0144
Loa Loa (eye worm) hypothetical protein 0.0038 0.0455 0.0939
Loa Loa (eye worm) phosphatidylinositol 3 0.0097 0.1461 0.3013
Loa Loa (eye worm) sugar transporter 0.0107 0.1631 0.3363
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0447 0.0921
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.0051 0.0106
Echinococcus multilocularis vesicular acetylcholine transporter 0.0297 0.4849 0.4849
Schistosoma mansoni pyruvate kinase 0.0058 0.0801 0.1145
Loa Loa (eye worm) hypothetical protein 0.0018 0.0125 0.0259
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0015 0.0068 0.0068
Schistosoma mansoni sugar transporter 0.0015 0.007 0.01
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0017 0.0104 0.0466
Echinococcus granulosus neuropeptide receptor A26 0.0014 0.0051 0.0051
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0166 0.0166
Schistosoma mansoni hypothetical protein 0.0014 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.0021 0.0166 0.0342
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.0051 0.0051
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.007 0.01
Echinococcus granulosus somatostatin receptor 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0021 0.0166 0.0342
Loa Loa (eye worm) hypothetical protein 0.0035 0.0413 0.0851
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0015 0.0068 0.0068
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0173 0.2749 0.5526
Loa Loa (eye worm) hypothetical protein 0.0025 0.0231 0.0476
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0114 0.0114
Echinococcus granulosus pyruvate kinase 0.0058 0.0801 0.0801
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0166 0.0166
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.0051 0.0051
Brugia malayi hypothetical protein 0.0015 0.007 0.0144
Brugia malayi vesicular acetylcholine transporter unc-17 0.0297 0.4849 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0125 0.0125
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0239 0.0239
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0107 0.1631 0.2331
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0231 0.1831
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.1504 0.1504
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0051 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0166 0.0342
Brugia malayi nuclear hormone receptor 0.0021 0.0166 0.0342
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.045 0.051
Trypanosoma brucei glucose transporter 1E 0.0033 0.0378 0.4213
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0114 0.0163
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0166 0.0166
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0297 0.4849 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0447 0.0921
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0166 0.0166
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0109 0.1661 0.1661
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0028 0.0288 0.3228
Brugia malayi Serotonin receptor 0.0014 0.0051 0.0106
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0378 0.1973
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0231 0.1831
Schistosoma mansoni zinc finger protein 0.0016 0.0083 0.0119
Echinococcus granulosus cpg binding protein 0.0033 0.0381 0.0381
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0125 0.0257
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0231 0.2201
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0447 0.0996
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0017 0.0104 0.0466
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.6995 0.6995
Brugia malayi Dopamine receptor protein 1 0.0014 0.0051 0.0106
Brugia malayi sulfakinin receptor protein 0.0014 0.0051 0.0106
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0447 0.2414
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.069 0.1422
Schistosoma mansoni hypothetical protein 0.0014 0.0051 0.0073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.045 0.0929
Onchocerca volvulus 0.0015 0.007 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0447 0.5155
Brugia malayi hypothetical protein 0.0014 0.0051 0.0106
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.022 0.2053
Trypanosoma brucei glucose transporter, putative 0.0033 0.0378 0.4213
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0131
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0378 0.1973
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.0051 0.0051
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0602 1 1
Schistosoma mansoni opsin-like receptor 0.0014 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.0062 0.0863 0.178
Giardia lamblia Rrm3p helicase 0.0017 0.0104 0.079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0166 0.0342
Trypanosoma brucei glucose transporter, putative 0.0033 0.0378 0.4213
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0413 0.0851
Brugia malayi hypothetical protein 0.0014 0.0051 0.0106
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Echinococcus granulosus glutamate receptor 2 0.0015 0.0068 0.0068
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0051 0.0051
Schistosoma mansoni coup transcription factor 0.0021 0.0166 0.0237
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0359 0.3689
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0319 0.0657
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0166 0.0342
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0891 0.0891
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0092 0.0301
Loa Loa (eye worm) hypothetical protein 0.0037 0.0447 0.0921
Onchocerca volvulus 0.0037 0.0447 0.0824
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0092 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0371 0.1927
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0447 0.0505
Brugia malayi pyruvate kinase 0.0012 0.0022 0.0046
Schistosoma mansoni hypothetical protein 0.0037 0.0433 0.0619
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.005 0.0663 0.0663
Leishmania major glucose transporter, lmgt3 0.0033 0.0378 0.4213
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.0051 0.0051
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.0051 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0447 0.5155
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0166 0.0342
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0015 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.0051 0.0073
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0371 0.0371
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.0051 0.0106
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0051 0.0051
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.0051 0.0051
Loa Loa (eye worm) sugar transporter 0.0015 0.007 0.0144
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0025 0.0244 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0231 0.0425
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0025 0.0244 0.2989
Echinococcus granulosus orexin receptor type 2 0.0014 0.0051 0.0051
Onchocerca volvulus 0.0015 0.007 0.0039
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0378 0.4213
Echinococcus granulosus pyruvate kinase 0.003 0.0321 0.0321
Echinococcus multilocularis G protein coupled receptor 139 0.0083 0.1226 0.1226
Leishmania major pyruvate kinase 0.0058 0.0801 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0166 0.0342
Entamoeba histolytica protein kinase, putative 0.0033 0.0371 0.3851
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.075 0.075
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0074 0.0074
Toxoplasma gondii ABC1 family protein 0.0037 0.0447 0.0836
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0058 0.0796 0.9941
Onchocerca volvulus 0.0015 0.007 0.0039
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0939 0.0939
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.045 0.5196
Onchocerca volvulus 0.0015 0.007 0.0039
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0058 0.0796 0.9941
Mycobacterium ulcerans hypothetical protein 0.0037 0.0447 0.5539
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.022 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0231 0.2819
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.005 0.0663 0.0663
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0166 0.0342
Schistosoma mansoni hypothetical protein 0.0017 0.0104 0.0148
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0091 0.0091
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0359 0.3125
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0091 0.0188
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0939 0.0939
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0051 0.0073
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0017 0.0104 0.0466
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.0051 0.0073
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.007 0.0144
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0058 0.0796 0.4655
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.0051 0.0073
Toxoplasma gondii sugar transporter ST3 0.0015 0.007 0.0068
Brugia malayi hypothetical protein 0.0014 0.0051 0.0106
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.007 0.007
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0231 0.1121
Schistosoma mansoni glucose transport protein 0.0107 0.1631 0.2331
Trichomonas vaginalis pyruvate kinase, putative 0.0058 0.0801 0.4683
Echinococcus multilocularis solute carrier family 22 0.0015 0.007 0.007
Brugia malayi neuropeptide F receptor 0.0014 0.0051 0.0106
Echinococcus multilocularis cpg binding protein 0.0033 0.0381 0.0381
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0058 0.0796 0.4655
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0359 0.0741
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0166 0.0237
Echinococcus multilocularis neuropeptide receptor 0.0083 0.1226 0.1226
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0109 0.1661 0.2375
Loa Loa (eye worm) pyruvate kinase 0.0058 0.0801 0.1651
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.022 0.2682
Loa Loa (eye worm) pyruvate kinase-PB 0.0041 0.0502 0.1036
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Echinococcus multilocularis sex peptide receptor 0.0014 0.0051 0.0051
Trypanosoma cruzi pyruvate kinase 2, putative 0.0058 0.0801 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0371 0.0682
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0015 0.0068 0.0068
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.005 0.0663 0.1368
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0239 0.0342
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0019 0.0143 0.0564
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0166 0.0237
Echinococcus multilocularis somatostatin receptor 0.0014 0.0051 0.0051
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0231 0.1831
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.075 0.1072
Brugia malayi beta-lactamase 0.0037 0.0447 0.0921
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0092 0.0092
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.022 0.0314
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0051 0.0073
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0239 0.0239
Echinococcus granulosus dnaJ subfamily B 0.0424 0.6995 0.6995
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0166 0.0166
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.022 0.2053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0166 0.0166
Brugia malayi Transient-receptor-potential like protein 0.0038 0.0455 0.0939
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0371 0.0764
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0051 0.0051
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Schistosoma mansoni sugar transporter 0.0015 0.007 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.0166 0.0342
Brugia malayi Probable ATP-dependent helicase DHX35 0.0018 0.0125 0.0258
Schistosoma mansoni transient receptor potential channel 0.0066 0.0939 0.1342
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0018 0.0113 0.0233
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0371 0.0371
Chlamydia trachomatis pyruvate kinase 0.0058 0.0801 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Schistosoma mansoni cpg binding protein 0.0033 0.0381 0.0544
Leishmania major hypothetical protein, conserved 0.0016 0.0083 0.0181
Brugia malayi hypothetical protein 0.0014 0.0051 0.0106
Trypanosoma cruzi pyruvate kinase 2, putative 0.0058 0.0801 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0166 0.0342
Brugia malayi steroid hormone receptor 0.0021 0.0166 0.0342
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0092 0.0301
Echinococcus granulosus zinc finger protein 0.0022 0.0187 0.0187
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.045 0.5196
Echinococcus granulosus voltage dependent calcium channel 0.0013 0.0036 0.0036
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.007 0.0144
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0447 0.0996
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0378 0.4213
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.0051 0.0106
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.007 0.0792
Brugia malayi putative neuropeptide receptor 0.0014 0.0051 0.0106
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0037 0.0433 0.4758
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0447 0.0638
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0166 0.0342
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0019 0.0143 0.0468
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0015 0.0068 0.0068
Echinococcus granulosus g protein coupled receptor 0.0014 0.0051 0.0051
Schistosoma mansoni myosin xvIII 0.0014 0.0051 0.0073
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0058 0.0801 0.1932
Mycobacterium tuberculosis Conserved protein 0.0037 0.0447 0.0996
Echinococcus granulosus geminin 0.0176 0.2789 0.2789
Echinococcus multilocularis geminin 0.0176 0.2789 0.2789
Echinococcus multilocularis voltage dependent calcium channel 0.005 0.0663 0.0663
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0331
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0144
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0051 0.0051
Chlamydia trachomatis glutamine binding protein 0.0025 0.0244 0.2989
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0231 0.0476
Schistosoma mansoni amine GPCR 0.0014 0.0051 0.0073
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0038 0.0455 0.0455
Echinococcus multilocularis serotonin receptor 0.0014 0.0051 0.0051
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0051 0.0051
Echinococcus granulosus transient receptor potential ion channel A 0.0095 0.1429 0.1429
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0371 0.0404
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0125 0.0147
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0231 0.1121
Loa Loa (eye worm) hypothetical protein 0.005 0.0663 0.1368
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0166 0.0166
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0231 0.2201
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0447 0.2414
Entamoeba histolytica protein kinase, putative 0.0033 0.0371 0.3851
Onchocerca volvulus Pyruvate kinase homolog 0.0058 0.0801 0.1562
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0051 0.0051
Onchocerca volvulus 0.0015 0.007 0.0039
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0166 0.0237
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0166 0.0342
Echinococcus multilocularis General substrate transporter 0.0092 0.1375 0.1375
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0447 0.0996
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.022 0.2682
Trypanosoma cruzi hexose transporter 0.0033 0.0378 0.4213
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0371 0.0404
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0092 0.0189
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0336 0.0336
Toxoplasma gondii pyruvate kinase PyKII 0.003 0.0321 0.0579
Trypanosoma brucei glucose transporter, putative 0.0033 0.0378 0.4213
Echinococcus multilocularis glutamate receptor NMDA 0.0105 0.1595 0.1595
Echinococcus multilocularis pyruvate kinase 0.0058 0.0801 0.0801
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.1631 0.3248
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0051 0.0051
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.1631 0.1631
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.069 0.1422
Plasmodium falciparum pyruvate kinase 2 0.003 0.0321 0.0337
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0371 0.0404
Entamoeba histolytica pyruvate kinase, putative 0.0041 0.0502 0.5753
Echinococcus multilocularis sodium channel protein 0.0023 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0125 0.0178
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.0051 0.0106
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0051 0.0073
Schistosoma mansoni hypothetical protein 0.0014 0.0051 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.0033 0.038 0.0783
Echinococcus granulosus g protein coupled receptor 0.0014 0.0051 0.0051
Echinococcus multilocularis nmda type glutamate receptor 0.011 0.168 0.168
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0017 0.0104 0.0466
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0051 0.0073
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0166 0.0239
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0051 0.0073
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0091 0.0188
Giardia lamblia Hexose transporter 0.0015 0.007 0.034
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0058 0.0796 0.4655
Loa Loa (eye worm) hypothetical protein 0.0018 0.0125 0.0259
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0166 0.0237
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.0051 0.0106
Loa Loa (eye worm) hypothetical protein 0.0018 0.0125 0.0258
Echinococcus granulosus TRP transient receptor potential channel 0.0038 0.0455 0.0455
Brugia malayi hypothetical protein 0.0015 0.007 0.0144
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.022 0.0952
Schistosoma mansoni vesicular acetylcholine transporter 0.0297 0.4849 0.6931
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.0051 0.0073
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.1631 0.1631
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.075 0.1072
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0445 0.0445
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0166 0.0166
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0231 0.2819
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0166 0.0237
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0891 0.0891
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.045 0.5196
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.022 0.0314
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0051 0.0051
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0092 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0051 0.0051
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0447 0.0447

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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