Detailed information for compound 652962

Basic information

Technical information
  • TDR Targets ID: 652962
  • Name: 4-(3-chlorophenyl)-N-(4-methoxyphenyl)-6-meth yl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxam ide
  • MW: 371.818 | Formula: C19H18ClN3O3
  • H donors: 3 H acceptors: 2 LogP: 2.59 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)C1=C(C)NC(=O)NC1c1cccc(c1)Cl
  • InChi: 1S/C19H18ClN3O3/c1-11-16(18(24)22-14-6-8-15(26-2)9-7-14)17(23-19(25)21-11)12-4-3-5-13(20)10-12/h3-10,17H,1-2H3,(H,22,24)(H2,21,23,25)
  • InChiKey: RYAPKKJVMSVQNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(3-chlorophenyl)-2-keto-N-(4-methoxyphenyl)-6-methyl-3,4-dihydro-1H-pyrimidine-5-carboxamide
  • 5983-50-6
  • T0514-7726
  • CBMicro_040163
  • Oprea1_433884
  • BIM-0039997.P001
  • BAS 01434424
  • Oprea1_722475
  • MixCom6_002147

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0146 0.1317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Onchocerca volvulus Matrilysin homolog 0.1037 0.6433 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0014 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0164
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0112 0.0123
Leishmania major alpha glucosidase II subunit, putative 0.0072 0.0376 0.298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Loa Loa (eye worm) hypothetical protein 0.0181 0.1056 0.1551
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Plasmodium falciparum mitochondrial ATP synthase F1, epsilon subunit, putative 0.0019 0.0039 0.1916
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0032
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0013 0.0074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0409 0.045
Onchocerca volvulus 0.0049 0.0229 0.0343
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0052 0.0725
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0231 0.1001
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.023 0.1363 0.3197
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0396 0.0915
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.039 0.0389
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0013 0.0042
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0012 0.0005
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0014 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0149 0.0858 0.1259
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0051 0.0318
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0091 0.1378
Schistosoma mansoni alpha-glucosidase 0.0281 0.1684 0.3954
Schistosoma mansoni ATP synthase alpha subunit mitochondrial 0.0014 0.0013 0.001
Trypanosoma brucei polo-like protein kinase 0.0097 0.053 0.424
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0011
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0073 0.0072
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0017 0.0032 0.0155
Loa Loa (eye worm) DR-78 0.0014 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0032
Schistosoma mansoni nuclear receptor 0.0014 0.0012 0.0008
Mycobacterium tuberculosis Conserved protein 0.0181 0.1056 0.1473
Schistosoma mansoni hypothetical protein 0.0299 0.1799 0.4227
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0321 0.1936 0.1935
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0014 0.0008 0.0011
Entamoeba histolytica hypothetical protein 0.0076 0.0396 0.6462
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0112 0.0246
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0685 0.1006
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0012 0.0005
Schistosoma mansoni hypothetical protein 0.0045 0.0206 0.0466
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0073 0.0095
Brugia malayi tailless protein 0.0014 0.0012 0.0005
Mycobacterium tuberculosis Conserved protein 0.0181 0.1056 0.1473
Brugia malayi Matrixin family protein 0.0341 0.2064 0.3024
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0231 0.0323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0321 0.1936 0.4549
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0231 0.372
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0216 0.0237
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0376 0.351
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.039 0.6357
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1155 0.717 1
Brugia malayi Matrixin family protein 0.0341 0.2064 0.3024
Brugia malayi conserved hypotetical protein 0.0014 0.0012 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0231 0.1794
Schistosoma mansoni alpha-glucosidase 0.0281 0.1684 0.3954
Echinococcus granulosus mitochondrial F1F0 ATP synthase subunit epsilon 0.0019 0.0039 0.0043
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0091 0.0789
Brugia malayi beta-lactamase family protein 0.0181 0.1056 0.1541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0075 0.0596
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0017 0.0032 0.0388
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0075
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0075 0.051
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0153 0.1347
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0072 0.0376 0.3482
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0112 0.0164
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0181 0.1056 0.1541
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0022 0.0022
Schistosoma mansoni coup transcription factor 0.003 0.0112 0.0246
Onchocerca volvulus 0.003 0.0112 0.0162
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0075 0.051
Loa Loa (eye worm) G protein alpha subunit 3 0.0014 0.0008 0.0011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0181 0.1056 0.1055
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.039 0.3613
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0112 0.0123
Schistosoma mansoni intermediate filament proteins 0.0026 0.0085 0.0182
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0073 0.0101
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0146 0.0203
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0073 0.0492
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0009 0.0002
Entamoeba histolytica hypothetical protein 0.0023 0.0064 0.0935
Schistosoma mansoni polycystin 1-related 0.01 0.0551 0.1281
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0074
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0245 0.1462 0.2139
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0146 0.016
Plasmodium vivax importin-beta 2, putative 0.0028 0.0098 0.0815
Echinococcus multilocularis microtubule associated protein 2 0.0689 0.4246 0.4246
Loa Loa (eye worm) runx1 0.0054 0.0261 0.0382
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0858 0.0857
Echinococcus granulosus bloom syndrome protein 0.0021 0.0052 0.0056
Mycobacterium ulcerans esterase/lipase LipP 0.0181 0.1056 0.4773
Schistosoma mansoni inositol monophosphatase 0.0075 0.039 0.09
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0022 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.029 0.1271
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0013 0.0018
Mycobacterium ulcerans hypothetical protein 0.0024 0.0073 0.0275
Brugia malayi hypothetical protein 0.0148 0.0851 0.124
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0012 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0323 0.0743
Echinococcus granulosus muscleblind protein 0.0149 0.0858 0.0943
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0032 0.0157
Loa Loa (eye worm) beta-lactamase 0.0181 0.1056 0.1551
Entamoeba histolytica hypothetical protein 0.0076 0.0396 0.6462
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0112 0.0153
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0032 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.053 0.4976
Trichomonas vaginalis maltase-glucoamylase, putative 0.0072 0.0376 0.351
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0321 0.1936 0.1935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Brugia malayi Glycosyl hydrolases family 31 protein 0.0072 0.0376 0.0541
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0112 0.0112
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0013 0.0006
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0012 0.0011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0231 0.372
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0011
Echinococcus multilocularis lamin 0.0026 0.0085 0.0085
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0017 0.0032 0.0155
Toxoplasma gondii ABC1 family protein 0.0181 0.1056 1
Onchocerca volvulus 0.0014 0.0013 0.0007
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0146 0.1096
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0008 0.0008
Echinococcus multilocularis lysosomal alpha glucosidase 0.0326 0.1969 0.1968
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0052 0.0415
Onchocerca volvulus 0.0148 0.0851 0.1312
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0216 0.0237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0073 0.0614
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0112 0.0164
Schistosoma mansoni DNA helicase recq5 0.0021 0.0052 0.0103
Brugia malayi nuclear receptor RXR 0.0016 0.0022 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.1056 0.2473
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0231 0.1001
Onchocerca volvulus 0.0014 0.0012 0.0005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.0224
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.039 0.364
Echinococcus multilocularis expressed protein 0.0014 0.0008 0.0007
Echinococcus granulosus tar DNA binding protein 0.0064 0.0323 0.0355
Echinococcus granulosus Niemann Pick C1 protein 0.0109 0.0608 0.0669
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.139 0.139
Leishmania major hypothetical protein, conserved 0.0024 0.0075 0.051
Brugia malayi hypothetical protein 0.0076 0.0396 0.057
Loa Loa (eye worm) hypothetical protein 0.0027 0.0091 0.0132
Loa Loa (eye worm) hypothetical protein 0.043 0.2624 0.3854
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0409 0.06
Schistosoma mansoni nuclear hormone receptor 0.003 0.0112 0.0246
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0073 0.0491
Mycobacterium ulcerans hypothetical protein 0.0181 0.1056 0.4773
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0323 0.0743
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0146 0.1317
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0376 0.298
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0323 0.0473
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0032
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0013 0.0042
Loa Loa (eye worm) hypothetical protein 0.0078 0.0409 0.06
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0052 0.032
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0073 0.0491
Mycobacterium ulcerans hypothetical protein 0.0024 0.0073 0.0275
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0323 0.0473
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0073 0.0275
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0017 0.0032 0.0155
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0112 0.0162
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0017
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0146 0.2303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Entamoeba histolytica hypothetical protein 0.0076 0.0396 0.6462
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0409 0.045
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0112 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0112 0.0153
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0112 0.0153
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0085 0.0124
Brugia malayi hypothetical protein 0.043 0.2624 0.3847
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0052 0.0056
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0013 0.0018
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0032 0.0155
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0181 0.1056 0.1551
Schistosoma mansoni hypothetical protein 0.0078 0.0409 0.0946
Onchocerca volvulus 0.0022 0.0061 0.0082
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.039 0.364
Echinococcus granulosus intermediate filament protein 0.0026 0.0085 0.0093
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0012 0.0011
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0112 0.0162
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0112 0.0112
Brugia malayi RNA binding protein 0.0064 0.0323 0.0463
Schistosoma mansoni hypothetical protein 0.0048 0.0221 0.0503
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0223 0.2046
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0073 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0216 0.1986
Loa Loa (eye worm) hypothetical protein 0.0181 0.1056 0.1551
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0112 0.0123
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0112 0.0246
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0008 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0321 0.1936 0.4549
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0146 0.016
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0073 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Brugia malayi TAR-binding protein 0.0064 0.0323 0.0463
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0112 0.0153
Loa Loa (eye worm) hypothetical protein 0.0168 0.0975 0.1431
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0321 0.1936 0.2835
Loa Loa (eye worm) matrix metalloproteinase 0.0341 0.2064 0.3032
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0231 0.1794
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0073 0.0152
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0012 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Mycobacterium tuberculosis Probable hydrolase 0.0181 0.1056 0.1473
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0014 0.0008 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.1056 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.0376 0.351
Trypanosoma brucei hypothetical protein, conserved 0.0181 0.1056 0.8558
Brugia malayi Matrixin family protein 0.0341 0.2064 0.3024
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0032 0.0034
Echinococcus multilocularis Niemann Pick C1 protein 0.0156 0.0903 0.0902
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0098 0.0097
Echinococcus multilocularis protein dispatched 1 0.0054 0.0258 0.0257
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0112 0.0112
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0073 0.0574
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0017 0.0032 0.0155
Leishmania major glycosyl hydrolase-like protein 0.0027 0.0091 0.0642
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0164
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0091 0.0789
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.029 0.2662
Echinococcus multilocularis lamin dm0 0.0026 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0076 0.0396 0.0915
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0323 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.053 0.4976
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0091 0.0789
Schistosoma mansoni inositol monophosphatase 0.0075 0.039 0.09
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0146 0.0326
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0052 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0223 0.2046
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0112 0.0246
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0323 0.0463
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0098 0.0814
Brugia malayi Inositol-1 0.0075 0.039 0.0561
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0146 0.0326
Onchocerca volvulus 0.0014 0.0012 0.0005
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0017 0.0032 0.0388
Schistosoma mansoni patched 1 0.0047 0.0216 0.0491
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.053 0.0767
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0017
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.053 0.424
Echinococcus granulosus expressed protein 0.0014 0.0008 0.0008
Mycobacterium tuberculosis Conserved protein 0.0024 0.0073 0.0101
Plasmodium falciparum importin beta, putative 0.0028 0.0098 0.6049
Brugia malayi Matrixin family protein 0.0341 0.2064 0.3024
Echinococcus granulosus GPCR family 2 0.0078 0.0409 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0146 0.0146
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0231 0.1794
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0112 0.0162
Loa Loa (eye worm) hypothetical protein 0.0181 0.1056 0.1551
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0032 0.0045
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0146 0.23
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0032 0.0034
Entamoeba histolytica hypothetical protein 0.0076 0.0396 0.6462
Loa Loa (eye worm) hypothetical protein 0.0028 0.0098 0.0142
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0146 0.0146
Brugia malayi steroid hormone receptor 0.003 0.0112 0.0153
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Brugia malayi nuclear receptor NHR-88 0.0014 0.0012 0.0005
Schistosoma mansoni hypothetical protein 0.0168 0.0975 0.2281
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.039 0.3092
Brugia malayi beta-lactamase family protein 0.0181 0.1056 0.1541
Mycobacterium ulcerans hydrolase 0.0363 0.2199 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0013 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.053 0.4976
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0017 0.0032 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0231 0.1001
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.053 0.0529
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0091 0.0642
Brugia malayi nuclear hormone receptor 0.0014 0.0012 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0012 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0112 0.0164
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0153 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0112 0.0153
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0112 0.0112
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0012 0.0008
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0012 0.0005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0112 0.0123
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.1056 1
Onchocerca volvulus 0.0014 0.0013 0.0007
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0098 0.0697
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0013 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.053 0.4976
Onchocerca volvulus 0.0014 0.0013 0.0007
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0231 0.1001
Echinococcus granulosus lamin dm0 0.0026 0.0085 0.0093
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0164
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0146 0.016
Brugia malayi Muscleblind-like protein 0.0149 0.0858 0.125
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0022 0.0021
Schistosoma mansoni microtubule-associated protein tau 0.0689 0.4246 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0012 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0091 0.0789
Echinococcus granulosus FTZ F1 alpha 0.003 0.0112 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0091 0.0789
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0052 0.0405
Brugia malayi nuclear receptor NHR-88 0.003 0.0112 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0112 0.0164
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0376 0.351
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0216 0.0216
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0032 0.0055
Schistosoma mansoni hypothetical protein 0.0045 0.0206 0.0466
Brugia malayi ecdysteroid receptor 0.003 0.0112 0.0153
Brugia malayi ATP synthase alpha chain, mitochondrial precursor, putative 0.0014 0.0013 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.014 0.0196
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.029 0.1271
Schistosoma mansoni hypothetical protein 0.0078 0.0409 0.0946
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.053 0.0582
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0032 0.0155
Schistosoma mansoni hypothetical protein 0.0045 0.0206 0.0466
Brugia malayi hypothetical protein 0.0016 0.0021 0.0018
Schistosoma mansoni nuclear receptor 0.0014 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0341 0.2064 0.3032
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Loa Loa (eye worm) hypothetical protein 0.043 0.2624 0.3854
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0013 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.029 0.1271
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0022 0.0021
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0685 0.1006
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.039 0.3092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0032
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.039 0.0428
Mycobacterium leprae conserved hypothetical protein 0.0181 0.1056 0.4773
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0017 0.0032 0.0155
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0052 0.0374
Mycobacterium leprae PROBABLE HYDROLASE 0.0363 0.2199 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0231 0.0339
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0323 0.0743
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0012 0.0008
Trypanosoma cruzi target of rapamycin kinase 3 0.0017 0.0032 0.0155
Onchocerca volvulus 0.0026 0.0085 0.012
Brugia malayi MH2 domain containing protein 0.0122 0.0685 0.0996
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.139 0.153
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0085 0.0124
Plasmodium vivax hypothetical protein, conserved 0.0181 0.1056 1
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0012 0.0008
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0012 0.0005
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0064 0.0424
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.053 0.123
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.029 0.2278
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0012 0.0011
Echinococcus multilocularis Protein lozenge 0.0054 0.0261 0.026
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0231 0.0328
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0008 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0112 0.0164
Brugia malayi ecdysone receptor 0.0014 0.0012 0.0005
Loa Loa (eye worm) hypothetical protein 0.0234 0.139 0.2041
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.0376 0.351
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0091 0.0642
Echinococcus multilocularis expressed conserved protein 0.0103 0.0567 0.0566
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0017 0.0032 0.0034
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0321 0.1936 0.2843
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.053 0.4976
Mycobacterium ulcerans hypothetical protein 0.0049 0.0231 0.1001
Plasmodium vivax ATP synthase epsilon chain, mitochondrial , putative 0.0019 0.0039 0.0258
Loa Loa (eye worm) hypothetical protein 0.0109 0.0608 0.0893
Schistosoma mansoni lamin 0.0026 0.0085 0.0182
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.0224
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0326 0.1969 0.2892
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0112 0.0153
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0013 0.0018
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0085 0.0114
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0013 0.0018
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0008 0.0007
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0112 0.0153
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Schistosoma mansoni survival motor neuron protein 0.0048 0.0221 0.0503
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0052 0.0064
Brugia malayi Importin beta-1 subunit 0.0028 0.0098 0.0131
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0376 0.351
Loa Loa (eye worm) hypothetical protein 0.0675 0.4156 0.6105
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0376 0.351
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0164
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0409 0.059
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.029 0.0405
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0231 0.0328
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0073 0.0072
Echinococcus granulosus importin subunit beta 1 0.0028 0.0098 0.0107
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0013 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0209 0.1232 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.146 0.9084 1
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0014 0.0008 0.0007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0112 0.0112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0321 0.1936 0.4549
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0181 0.1056 0.1473
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0181 0.1056 0.4773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0032
Loa Loa (eye worm) hypothetical protein 0.0049 0.0231 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0146 0.1317
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0112 0.0246
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.014 0.0196
Echinococcus multilocularis geminin 0.0521 0.3191 0.319
Onchocerca volvulus 0.0181 0.1056 0.1631
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0075 0.4428
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0231 0.1001
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0014 0.0008 0.0008
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0052 0.0064
Onchocerca volvulus 0.0026 0.0085 0.012
Schistosoma mansoni hypothetical protein 0.0521 0.3191 0.751
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.029 0.0666
Echinococcus multilocularis lysosomal alpha glucosidase 0.0326 0.1969 0.1968
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0112 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0112 0.0153
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0017 0.0032 0.0055
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0146 0.0146
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0013 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0112 0.0164
Brugia malayi hypothetical protein 0.0014 0.0012 0.0005
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0112 0.0246
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0231 0.1001
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0231 0.1001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0008 0.0008
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0052 0.0374
Echinococcus granulosus ATP synthase subunit alpha mitochondrial 0.0014 0.0013 0.0013
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0032 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0012 0.0016
Loa Loa (eye worm) ATP synthase subunit epsilon 0.0019 0.0039 0.0057
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0032 0.0155
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.039 0.3092
Onchocerca volvulus 0.0049 0.0231 0.0347
Brugia malayi ATP synthase epsilon chain, mitochondrial 0.0019 0.0039 0.0046
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0052 0.0415
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0376 0.298
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0013 0.0006
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0112 0.0246
Schistosoma mansoni thyroid hormone receptor 0.003 0.0112 0.0246
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0052 0.0415
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0022 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0112 0.0153
Brugia malayi Calcitonin receptor-like protein seb-1 0.0245 0.1462 0.2139
Loa Loa (eye worm) hypothetical protein 0.0181 0.1056 0.1551
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.1056 0.8558
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0181 0.1056 0.1473
Brugia malayi latrophilin 2 splice variant baaae 0.0168 0.0975 0.1422
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0109
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0073 0.0275
Trypanosoma brucei glucosidase, putative 0.0072 0.0376 0.298
Mycobacterium tuberculosis Probable ATP synthase beta chain AtpD 0.0014 0.0013 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Echinococcus granulosus lysosomal alpha glucosidase 0.0326 0.1969 0.2167
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0214
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0098 0.0697
Onchocerca volvulus 0.0341 0.2064 0.32
Brugia malayi Hemopexin family protein 0.0422 0.2573 0.3772
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.1072
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0017 0.0032 0.0155
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.029 0.029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0231 0.372
Mycobacterium ulcerans beta-lactamase 0.0181 0.1056 0.4773
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.0224
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0376 0.351
Schistosoma mansoni zinc finger protein 0.0014 0.0012 0.0008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0112 0.0246
Brugia malayi Niemann-Pick C1 protein precursor 0.0109 0.0608 0.0883
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0112 0.0112
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0012 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0112 0.0123
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0396 0.0435
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0073 0.0079
Mycobacterium tuberculosis Probable lipase LipD 0.0181 0.1056 0.1473
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.146 0.9084 0.9084
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0032 0.0155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0112 0.0112
Brugia malayi nuclear receptor RXR 0.0014 0.0012 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0112 0.0123
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0321 0.1936 0.2131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0012 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0231 0.1001
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0072 0.0376 0.0551
Onchocerca volvulus Matrix metalloproteinase homolog 0.0704 0.4341 0.6744
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0052 0.2785
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0153 0.0643
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0363 0.2199 0.323
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0013 0.0018
Trichomonas vaginalis sucrase-isomaltase, putative 0.0072 0.0376 0.351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Echinococcus multilocularis muscleblind protein 0.0149 0.0858 0.0857
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0124
Loa Loa (eye worm) inositol-1 0.0075 0.039 0.0571
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0075 0.0596
Loa Loa (eye worm) RNA binding protein 0.0064 0.0323 0.0473
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0012 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0231 0.0328
Leishmania major hypothetical protein, conserved 0.0209 0.1232 1
Echinococcus multilocularis tumor protein p63 0.0334 0.202 0.2019
Schistosoma mansoni alpha glucosidase 0.0072 0.0376 0.0868
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.029 0.0666
Loa Loa (eye worm) hypothetical protein 0.0245 0.1462 0.2147
Giardia lamblia Kinase, PLK 0.0097 0.053 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0216 0.0317
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0075 0.051
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0323 0.0743
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.053 0.424
Echinococcus multilocularis GPCR, family 2 0.0078 0.0409 0.0408
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0052 0.032
Mycobacterium tuberculosis Probable esterase LipL 0.0181 0.1056 0.1473
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0229 0.0521
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0409 0.0408
Leishmania major importin beta-1 subunit, putative 0.0023 0.0064 0.0424
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0323 0.0743
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0221 0.0313
Echinococcus granulosus tumor protein p63 0.0334 0.202 0.2223
Echinococcus granulosus neutral alpha glucosidase AB 0.0072 0.0376 0.0413
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0009 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Mycobacterium ulcerans lipase LipD 0.0181 0.1056 0.4773
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0146 0.1096
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0112 0.0246
Loa Loa (eye worm) hypothetical protein 0.0148 0.0851 0.125
Onchocerca volvulus Matrilysin homolog 0.0341 0.2064 0.32
Loa Loa (eye worm) hypothetical protein 0.0181 0.1056 0.1551
Onchocerca volvulus 0.0181 0.1056 0.1631
Echinococcus granulosus geminin 0.0521 0.3191 0.3512
Loa Loa (eye worm) matrixin family protein 0.0704 0.4341 0.6377
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0013 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.1056 1
Schistosoma mansoni lamin 0.0026 0.0085 0.0182
Brugia malayi RNA, U transporter 1 0.008 0.0422 0.0608
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0017 0.0032 0.0031
Leishmania major hypothetical protein, conserved 0.0181 0.1056 0.8558
Mycobacterium leprae Probable lipase LipE 0.0181 0.1056 0.4773
Brugia malayi Glycosyl hydrolases family 31 protein 0.0326 0.1969 0.2884
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0153 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0112 0.0153
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.039 0.0533
Loa Loa (eye worm) hypothetical protein 0.0181 0.1056 0.1551
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0216 0.0317
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.029 0.0319
Brugia malayi beta-lactamase 0.0181 0.1056 0.1541
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0027 0.0091 0.0129
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0409 0.0408
Trichomonas vaginalis esterase, putative 0.0181 0.1056 1
Echinococcus granulosus expressed conserved protein 0.0103 0.0567 0.0623
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0229 0.0335
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.014 0.0196
Echinococcus granulosus microtubule associated protein 2 0.0689 0.4246 0.4674
Onchocerca volvulus 0.0189 0.1106 0.1708
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0164
Brugia malayi CHE-14 protein 0.0047 0.0216 0.0306
Trypanosoma cruzi hypothetical protein, conserved 0.0209 0.1232 1
Onchocerca volvulus 0.0422 0.2573 0.3992
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.1056 1
Toxoplasma gondii atp synthase F1, epsilon subunit, putative 0.0019 0.0039 0.0257
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.0224
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0013 0.001
Echinococcus granulosus Niemann Pick C1 protein 0.0156 0.0903 0.0993
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0011
Echinococcus granulosus beta LACTamase domain containing family member 0.0181 0.1056 0.1162
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.0224
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0078 0.0409 0.0946
Onchocerca volvulus 0.0181 0.1056 0.1631
Echinococcus multilocularis ATP synthase subunit alpha, mitochondrial 0.0014 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0049 0.0231 0.0339
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0032 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.1056 0.8558
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0409 0.059
Echinococcus multilocularis protein patched 0.0047 0.0216 0.0216
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.053 0.8689
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0396 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0012 0.0011
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0341 0.15
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0013 0.0006
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0341 0.0475
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Loa Loa (eye worm) RecQ helicase 0.0021 0.0052 0.0075
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0675 0.4156 0.9787
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0111 0.0619 0.1441
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0012 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0112 0.0153
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.0376 0.6129
Brugia malayi nuclear receptor NHR-67 0.0014 0.0012 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0091 0.0789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0112 0.0153
Loa Loa (eye worm) hypothetical protein 0.0058 0.0283 0.0414
Brugia malayi Matrixin family protein 0.1097 0.6807 1
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.1056 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0091 0.0789
Loa Loa (eye worm) oxidoreductase 0.0014 0.0013 0.0017
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0052 0.0051
Brugia malayi hypothetical protein 0.0024 0.0075 0.0098
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.053 0.0777
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0052 0.0075
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0153 0.0214
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0011
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0112 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0112 0.0153
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.053 0.0812
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0052 0.0064
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0112 0.0112
Schistosoma mansoni DNA helicase recq1 0.0021 0.0052 0.0103
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0017 0.0032 0.0155
Schistosoma mansoni hypothetical protein 0.0019 0.0039 0.0074
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.053 0.424
Brugia malayi intermediate filament protein 0.0026 0.0085 0.0114
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0245 0.1462 0.2147
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0109 0.0608 1
Echinococcus multilocularis snurportin 1 0.0299 0.1799 0.1799
Brugia malayi nuclear hormone receptor 0.003 0.0112 0.0153
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0012 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0064 0.0535
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0341 0.2064 0.3032
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0091 0.0122
Onchocerca volvulus ATP synthase subunit alpha, mitochondrial homolog 0.0014 0.0013 0.0007
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0012 0.0005
Schistosoma mansoni importin beta-1 0.0028 0.0098 0.0211
Brugia malayi hypothetical protein 0.0016 0.0022 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0112 0.0164
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0146 0.1096
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.1056 0.2473
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.1799 0.2643
Loa Loa (eye worm) hypothetical protein 0.0149 0.0858 0.1259
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0013 0.0001
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0073 0.0079
Echinococcus granulosus lamin 0.0026 0.0085 0.0093
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.0376 0.6129
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.1141 0.7085 1
Loa Loa (eye worm) matrixin family protein 0.1097 0.6807 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0032 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.014 0.0196
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0022 0.0032
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0112 0.0164
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0032 0.0031
Schistosoma mansoni hypothetical protein 0.0045 0.0206 0.0466
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0091 0.0789
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0052 0.0051
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0181 0.1056 0.1473
Onchocerca volvulus 0.0048 0.0221 0.0332
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0164
Echinococcus granulosus snurportin 1 0.0299 0.1799 0.198
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0064 0.0535
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0422 0.2573 0.6052
Schistosoma mansoni hypothetical protein 0.0078 0.0409 0.0946
Toxoplasma gondii target of rapamycin (TOR), putative 0.0017 0.0032 0.0181
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Mycobacterium tuberculosis Conserved protein 0.0181 0.1056 0.1473
Schistosoma mansoni kinase 0.0049 0.0231 0.0525
Onchocerca volvulus 0.043 0.2624 0.4071
Brugia malayi hypothetical protein 0.0234 0.139 0.2033
Echinococcus multilocularis musashi 0.0026 0.0085 0.0085
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0231 0.1001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0231 0.0323
Brugia malayi hypothetical protein 0.0014 0.0012 0.0005
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0363 0.2199 0.3222
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0013 0.0012
Trypanosoma brucei hypothetical protein, conserved 0.0209 0.1232 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0052 0.2785
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0112 0.0153
Echinococcus multilocularis mitochondrial F1F0 ATP synthase subunit epsilon 0.0019 0.0039 0.0039
Mycobacterium tuberculosis Probable ATP synthase alpha chain AtpA 0.0014 0.0013 0.0018
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0013 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.053 0.4976
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0012 0.0012
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0013 0.0018
Schistosoma mansoni hypothetical protein 0.0521 0.3191 0.751
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0012 0.0016
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0032 0.0157
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0052 0.032
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.039 0.3092
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0064 0.0535
Echinococcus multilocularis Niemann Pick C1 protein 0.0109 0.0608 0.0608
Brugia malayi hypothetical protein 0.0016 0.0022 0.0021
Echinococcus multilocularis neutral alpha glucosidase AB 0.0072 0.0376 0.0375
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0013 0.0006
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0146 0.1096
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0073 0.0275
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.039 0.364
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.053 0.4976
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0112 0.0153
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.039 0.1725
Mycobacterium tuberculosis Probable lipase LipE 0.0181 0.1056 0.1473
Schistosoma mansoni thyroid hormone receptor 0.003 0.0112 0.0246
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0075 0.4428
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0112 0.0153
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0321 0.1936 0.2131
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0363 0.2199 0.3067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Schistosoma mansoni lozenge 0.0054 0.0261 0.0596
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.0091 0.0642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0032 0.0222
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0073 0.0492
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0013 0.0006

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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