Detailed information for compound 663520

Basic information

Technical information
  • TDR Targets ID: 663520
  • Name: 4-chloro-3-[5-[(E)-(2,4-dioxo-3-prop-2-ynyl-1 ,3-thiazolidin-5-ylidene)methyl]furan-2-yl]be nzoic acid
  • MW: 387.794 | Formula: C18H10ClNO5S
  • H donors: 1 H acceptors: 4 LogP: 3.41 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cc(c2ccc(o2)/C=C\2/SC(=O)N(C2=O)CC#C)c(cc1)Cl
  • InChi: 1S/C18H10ClNO5S/c1-2-7-20-16(21)15(26-18(20)24)9-11-4-6-14(25-11)12-8-10(17(22)23)3-5-13(12)19/h1,3-6,8-9H,7H2,(H,22,23)/b15-9+
  • InChiKey: BFEDZBITJOETJI-OQLLNIDSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-3-[5-[(E)-(2,4-dioxo-3-prop-2-ynyl-thiazolidin-5-ylidene)methyl]-2-furyl]benzoic acid
  • 4-chloro-3-[5-[(E)-(2,4-dioxo-3-prop-2-ynyl-5-thiazolidinylidene)methyl]-2-furyl]benzoic acid
  • 4-chloro-3-[5-[(E)-(2,4-diketo-3-propargyl-thiazolidin-5-ylidene)methyl]-2-furyl]benzoic acid
  • STK151915

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0117 0.0628
Schistosoma mansoni fatty acid binding protein 0.0035 0.0113 0.0185
Loa Loa (eye worm) hypothetical protein 0.0035 0.0117 0.0191
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0067 0.0319 0.6744
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0059 0.1249
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0147 0.0737
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0147 0.0794
Schistosoma mansoni fatty acid binding protein 0.0035 0.0113 0.0185
Schistosoma mansoni alpha-glucosidase 0.0137 0.0768 0.1255
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1852 0.9984
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0117 0.0791
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0012 0.0012
Treponema pallidum fructose-bisphosphate aldolase 0.0307 0.1852 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0117 0.057
Brugia malayi mbt repeat family protein 0.0054 0.0236 0.0723
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0116 0.0625
Schistosoma mansoni hypothetical protein 0.0505 0.3119 0.5099
Loa Loa (eye worm) RNA binding protein 0.0061 0.0283 0.0462
Schistosoma mansoni DNA polymerase eta 0.0019 0.0012 0.0019
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.0848 0.4539
Loa Loa (eye worm) glutaminase 2 0.0307 0.1855 0.3033
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0079 0.0129
Trichomonas vaginalis importin beta-1, putative 0.0074 0.0363 0.1955
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0086 0.0141
Loa Loa (eye worm) hypothetical protein 0.0097 0.0511 0.0836
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0074 0.0363 0.1955
Schistosoma mansoni ap endonuclease 0.004 0.0147 0.0241
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0625
Onchocerca volvulus 0.0092 0.048 0.2881
Schistosoma mansoni ran 0.0067 0.0319 0.0521
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0059 0.1249
Schistosoma mansoni alpha glucosidase 0.0035 0.0116 0.019
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0097
Schistosoma mansoni zinc finger protein 0.0021 0.0026 0.0043
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0062 0.0284 0.0464
Echinococcus multilocularis histone acetyltransferase MYST2 0.0062 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0044 0.0174 0.0284
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0012 0.0244
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0117 0.057
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0147 0.0793
Echinococcus granulosus zinc finger protein 0.0021 0.0026 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0059 0.1354
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0462
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0462
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0117 0.0357
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0117 0.057
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0116 0.0625
Echinococcus granulosus importin subunit beta 1 0.0091 0.0473 0.0773
Trypanosoma brucei importin beta-1 subunit, putative 0.0091 0.0473 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0117 0.0791
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0147 0.3861
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0462
Loa Loa (eye worm) hypothetical protein 0.0035 0.0117 0.0191
Echinococcus granulosus dna polymerase eta 0.0019 0.0012 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0472 0.0771
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0012 0.0019
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.091 0.1487
Leishmania major DNA polymerase kappa, putative 0.0019 0.0012 0.0318
Schistosoma mansoni myelin transcription factor 1 myt1 0.0062 0.0284 0.0464
Brugia malayi Bromodomain containing protein 0.0082 0.0413 0.1263
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0062 0.0284 0.0869
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0117 0.2991
Schistosoma mansoni hypothetical protein 0.0031 0.0086 0.0141
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0117 0.2465
Echinococcus granulosus dna polymerase kappa 0.0019 0.0012 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1852 0.9984
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0086 0.0264
Echinococcus granulosus snurportin 1 0.0973 0.6118 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0147 0.4057
Loa Loa (eye worm) hypothetical protein 0.0091 0.0473 0.0773
Mycobacterium ulcerans glutaminase 0.0307 0.1855 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.0848 0.6302
Brugia malayi beta-lactamase family protein 0.0035 0.0117 0.0357
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0059 0.1249
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0117 0.0191
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0472 0.0771
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0244
Brugia malayi Bromodomain containing protein 0.0042 0.0157 0.048
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0047 0.0077
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0047 0.0047
Onchocerca volvulus 0.0035 0.0117 0.0221
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0283 0.0283
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0236 0.1097
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.0848 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0117 0.0191
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0625
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0116 0.3198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0472 0.0771
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0116 0.2975
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0205 0.0336
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0236 0.0386
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.2452
Leishmania major GTP-binding protein, putative 0.0067 0.0319 0.8795
Plasmodium vivax SET domain protein, putative 0.0031 0.0086 0.1827
Echinococcus granulosus GTP binding nuclear protein Ran 0.0067 0.0319 0.0521
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0147 0.0793
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0236 0.0386
Echinococcus multilocularis fatty acid binding protein FABP2 0.0035 0.0113 0.0113
Plasmodium vivax importin-beta 2, putative 0.0091 0.0473 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0117 0.0191
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0067 0.0319 0.8756
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0117 0.2465
Schistosoma mansoni importin beta-1 0.0091 0.0473 0.0773
Brugia malayi mbt repeat family protein 0.0054 0.0236 0.0723
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0147 0.3861
Echinococcus granulosus GPCR family 2 0.0031 0.0086 0.0141
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0147 0.5
Leishmania major DNA polymerase eta, putative 0.0019 0.0012 0.0318
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0066 0.0315 0.0514
Toxoplasma gondii exonuclease III APE 0.004 0.0147 0.311
Loa Loa (eye worm) hypothetical protein 0.0035 0.0117 0.0191
Trichomonas vaginalis glutaminase, putative 0.0307 0.1855 1
Trypanosoma brucei unspecified product 0.0019 0.0012 0.0244
Schistosoma mansoni alpha-glucosidase 0.0137 0.0768 0.1255
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0062 0.0284 0.0284
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0147 0.1021
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0472 0.0472
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0525 0.1606
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0511 0.0836
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0086 0.0141
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0013 0.0021
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0012 0.0318
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0117 0.0191
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0487 0.3004 0.491
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1852 0.9984
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0009 0.0014
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0067 0.0319 0.6744
Brugia malayi hypothetical protein 0.0487 0.3004 0.9193
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0012 0.0244
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0067 0.0319 0.6744
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0306 0.05
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.1852 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0117 0.0791
Trichomonas vaginalis esterase, putative 0.0035 0.0117 0.0628
Onchocerca volvulus 0.0035 0.0117 0.0221
Schistosoma mansoni hypothetical protein 0.0022 0.0034 0.0055
Schistosoma mansoni survival motor neuron protein 0.0099 0.0525 0.0858
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0244
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0117 0.0791
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0244
Schistosoma mansoni hypothetical protein 0.0066 0.0315 0.0514
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0116 0.0625
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0205 0.0205
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0147 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0244
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0315 0.0963
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0221 0.1307 0.1307
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0283 0.0462
Echinococcus multilocularis GPCR, family 2 0.0031 0.0086 0.0086
Echinococcus multilocularis survival motor neuron protein 1 0.0487 0.3004 0.3004
Brugia malayi RNA binding protein 0.0061 0.0283 0.0866
Loa Loa (eye worm) hypothetical protein 0.0042 0.0157 0.0257
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.0626
Loa Loa (eye worm) hypothetical protein 0.0062 0.0284 0.0464
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0117 0.0628
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0147 0.045
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.1262 0.2062
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0117 0.0791
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.014 0.0229
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0012 0.0062
Echinococcus granulosus survival motor neuron protein 1 0.0487 0.3004 0.491
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0462
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0306 0.0306
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0059 0.1354
Echinococcus granulosus tar DNA binding protein 0.0061 0.0283 0.0462
Loa Loa (eye worm) MBCTL1 0.0062 0.0284 0.0464
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0147 0.0736
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0012 0.0244
Leishmania major hypothetical protein, conserved 0.0035 0.0117 0.3214
Echinococcus multilocularis dna polymerase eta 0.0019 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0244
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0086 0.0141
Brugia malayi PHD-finger family protein 0.0027 0.0063 0.0194
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0047 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0117 0.0628
Mycobacterium tuberculosis Conserved protein 0.0035 0.0117 0.0791
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0086 0.0264
Mycobacterium ulcerans lipase LipD 0.0035 0.0117 0.057
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0116 0.019
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0009 0.0009
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0116 0.019
Schistosoma mansoni ap endonuclease 0.004 0.0147 0.0241
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0086 0.0141
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1852 0.9984
Brugia malayi Pre-SET motif family protein 0.0031 0.0086 0.0265
Trypanosoma brucei importin beta-1 subunit, putative 0.0091 0.0473 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0074 0.0363 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0147 0.0147
Schistosoma mansoni glutaminase 0.0307 0.1855 0.3033
Onchocerca volvulus 0.0244 0.1451 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0973 0.6118 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0244
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.091 0.091
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0147 0.311
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1852 0.9984
Toxoplasma gondii ABC1 family protein 0.0035 0.0117 0.2465
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.0528 0.3268 0.5341
Trichomonas vaginalis set domain proteins, putative 0.0244 0.1451 0.7822
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.091 0.1487
Leishmania major importin beta-1 subunit, putative 0.0074 0.0363 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0147 0.0241
Loa Loa (eye worm) glutaminase 0.0307 0.1855 0.3033
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0283 0.0866
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0012 0.0244
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0009 0.0014
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0067 0.0319 0.6744
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0117 0.0791
Schistosoma mansoni hypothetical protein 0.0505 0.3119 0.5099
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0625
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0116 0.0116
Brugia malayi hypothetical protein 0.0026 0.0059 0.0181
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0009 0.0014
Schistosoma mansoni hypothetical protein 0.0973 0.6118 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0086 0.0086
Echinococcus granulosus geminin 0.0505 0.3119 0.5099
Echinococcus multilocularis snurportin 1 0.0973 0.6118 0.6118
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0511 0.1565
Schistosoma mansoni hypothetical protein 0.0031 0.0086 0.0141
Brugia malayi RNA, U transporter 1 0.0259 0.1549 0.474
Schistosoma mansoni hypothetical protein 0.0031 0.0086 0.0141
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0067 0.0319 0.0976
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0059 0.1249
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0117 0.0628
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0116 0.0355
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0067 0.0319 0.0521
Onchocerca volvulus 0.0035 0.0117 0.0221
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0147 0.311
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.1852 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0012 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0116 0.2975
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0012 0.0062
Plasmodium falciparum importin beta, putative 0.0091 0.0473 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0221 0.1307 0.2136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1852 0.9984
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0236 0.0236
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0117 0.0191
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.091 0.2784
Onchocerca volvulus 0.0099 0.0525 0.3213
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0059 0.1249
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1852 0.9984
Echinococcus granulosus fatty acid binding protein FABP2 0.0035 0.0113 0.0185
Loa Loa (eye worm) hypothetical protein 0.0047 0.0187 0.0306
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0086 0.1827
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0147 0.311
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.091 0.091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0472 0.0771
Echinococcus multilocularis importin subunit beta 1 0.0091 0.0473 0.0473
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0511 0.1565
Schistosoma mansoni hypothetical protein 0.0099 0.0525 0.0858
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0462
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0117 0.0791
Onchocerca volvulus 0.0054 0.0236 0.1097
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0034 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0244
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.0528 0.3268 1
Echinococcus granulosus fatty acid binding protein FABP2 0.0035 0.0113 0.0185
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0472 0.1444
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0714 0.1168
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0625
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0012 0.0035
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0116 0.0626
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 0.1852 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0067 0.0319 0.0319
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0031 0.0086 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0117 0.2991
Brugia malayi beta-lactamase family protein 0.0035 0.0117 0.0357
Brugia malayi MH2 domain containing protein 0.0129 0.0714 0.2187
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0117 0.0791
Mycobacterium ulcerans beta-lactamase 0.0035 0.0117 0.057
Brugia malayi glutaminase DH11.1 0.0307 0.1855 0.5678
Echinococcus multilocularis geminin 0.0505 0.3119 0.3119
Brugia malayi beta-lactamase 0.0035 0.0117 0.0357
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0067 0.0319 0.8756
Brugia malayi Importin beta-1 subunit 0.0091 0.0473 0.1448
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0244
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0205 0.0336
Trichomonas vaginalis ran, putative 0.0067 0.0319 0.172
Echinococcus multilocularis zinc finger protein 0.0021 0.0026 0.0026
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0086 0.0141
Brugia malayi Pre-SET motif family protein 0.0214 0.1262 0.3861
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0086 0.0086
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0236 0.0386
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0116 0.0625
Toxoplasma gondii HEAT repeat-containing protein 0.0091 0.0473 1
Brugia malayi TAR-binding protein 0.0061 0.0283 0.0866
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.1339 1
Schistosoma mansoni bromodomain containing protein 0.0069 0.0331 0.0541
Loa Loa (eye worm) hypothetical protein 0.0035 0.0117 0.0191
Leishmania major hypothetical protein, conserved 0.0026 0.0059 0.1629
Schistosoma mansoni hypothetical protein 0.0337 0.2048 0.3347
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0236 0.0386
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0386
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0244
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0472 0.0472
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0012 0.0244
Entamoeba histolytica Ran family GTPase 0.0067 0.0319 0.1722
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0074 0.0363 0.1955
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0116 0.0625
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0283 0.0462
Echinococcus multilocularis fatty acid binding protein FABP2 0.0035 0.0113 0.0113
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0205 0.0336
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0472 0.0771
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0012 0.0019
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0117 0.0117
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0086 0.0086
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0117 0.0791
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0012 0.0012
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0236 0.0386
Loa Loa (eye worm) beta-lactamase 0.0035 0.0117 0.0191
Entamoeba histolytica hypothetical protein 0.0074 0.0363 0.1958
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0117 0.0628
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0714 0.1168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0472 0.0771
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1852 0.9984
Loa Loa (eye worm) hypothetical protein 0.0049 0.0205 0.0336
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0236 0.0386
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0067 0.0319 0.167
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0012 0.0062
Echinococcus granulosus histone acetyltransferase MYST2 0.0062 0.0284 0.0464
Loa Loa (eye worm) hypothetical protein 0.0035 0.0117 0.0191
Schistosoma mansoni ran 0.0067 0.0319 0.0521
Trypanosoma brucei glucosidase, putative 0.0035 0.0116 0.2452
Loa Loa (eye worm) hypothetical protein 0.0077 0.0383 0.0626

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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