Detailed information for compound 688083

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 407.419 | Formula: C22H21N3O5
  • H donors: 1 H acceptors: 3 LogP: 3.05 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)NC(=O)c1nn(c(=O)cc1OC)c1ccccc1C
  • InChi: 1S/C22H21N3O5/c1-4-30-22(28)15-9-11-16(12-10-15)23-21(27)20-18(29-3)13-19(26)25(24-20)17-8-6-5-7-14(17)2/h5-13H,4H2,1-3H3,(H,23,27)
  • InChiKey: GHYIYJXXUWQUKP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dna polymerase eta 0.0065 0.0746 0.0716
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0281 0.0588
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0338 0.0307
Brugia malayi Bromodomain containing protein 0.0084 0.101 0.2664
Leishmania major hypothetical protein, conserved 0.0044 0.0434 0.0949
Brugia malayi jmjC domain containing protein 0.0044 0.0434 0.1144
Brugia malayi Pre-SET motif family protein 0.0212 0.2875 0.7587
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0077 0.0203
Brugia malayi beta-lactamase 0.0037 0.0331 0.0873
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0044 0.0434 0.0949
Plasmodium vivax hypothetical protein, conserved 0.003 0.023 0.5163
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0224 0.0192
Brugia malayi beta-lactamase family protein 0.0037 0.0331 0.0873
Loa Loa (eye worm) hypothetical protein 0.0068 0.0779 0.2056
Echinococcus granulosus lysine specific demethylase 5A 0.0169 0.224 0.2215
Loa Loa (eye worm) hypothetical protein 0.0093 0.1147 0.3027
Schistosoma mansoni zinc finger protein 0.0043 0.0418 0.0387
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0427 0.0932
Loa Loa (eye worm) hypothetical protein 0.0084 0.1012 0.267
Schistosoma mansoni phd/f-box containing protein 0.0044 0.0434 0.0403
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0601 0.0571
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.024 0.0209
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.024 0.0209
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0331 0.0873
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.4263 1
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0504 0.0473
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.023 0.0198
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0308 0.4263 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0775 0.2044
Schistosoma mansoni jumonji/arid domain-containing protein 0.0169 0.224 0.2215
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0331 0.03
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0276 0.379 0.377
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.2875 0.7587
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0601 0.0571
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0427 0.0932
Leishmania major hypothetical protein, conserved 0.0033 0.0282 0.0591
Loa Loa (eye worm) hypothetical protein 0.0276 0.379 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0746 0.1687
Plasmodium falciparum phd finger protein, putative 0.003 0.023 0.4919
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.4119 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0077 0.1535
Brugia malayi PHD-finger family protein 0.0054 0.0586 0.1547
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0369 0.0338
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0352 0.3099
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Brugia malayi mbt repeat family protein 0.0049 0.0504 0.133
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0331 0.0629
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0276 0.379 0.377
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0357 0.0943
Loa Loa (eye worm) PHD-finger family protein 0.003 0.023 0.0606
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0331 0.03
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.0935 0.0906
Trichomonas vaginalis set domain proteins, putative 0.0242 0.33 0.7974
Trypanosoma brucei cysteine peptidase C (CPC) 0.0091 0.1116 0.2561
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0331 0.1226
Schistosoma mansoni phosphatidylserine receptor 0.0044 0.0434 0.0403
Schistosoma mansoni zinc finger protein 0.0033 0.0282 0.0251
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1909 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0077 0.5
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.023 0.1991
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0369 0.0797
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0601 0.0571
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1909 0.8838
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0369 0.1064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.4119 1
Schistosoma mansoni ap endonuclease 0.0019 0.0077 0.0045
Mycobacterium ulcerans lipase LipD 0.0037 0.0331 0.1226
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0044 0.0434 0.0949
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0032 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0369 0.0724
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0504 0.0473
Echinococcus granulosus lysine specific demethylase 6a 0.0044 0.0434 0.0403
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0032 0.0206
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0775 0.2044
Trypanosoma cruzi ISWI complex protein 0.0033 0.0282 0.0591
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0076 0.1086
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0369 0.0974
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.023 0.1991
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0032 0.0085
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0536 0.1413
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0276 0.379 0.8881
Onchocerca volvulus 0.0242 0.33 1
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0114 0.0083
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0331 0.0943
Schistosoma mansoni hypothetical protein 0.0035 0.0303 0.0271
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0077 0.0105
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0331 0.0943
Leishmania major DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Loa Loa (eye worm) hypothetical protein 0.0037 0.0331 0.0873
Loa Loa (eye worm) beta-lactamase 0.0037 0.0331 0.0873
Onchocerca volvulus 0.003 0.024 0.0034
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0369 0.0724
Mycobacterium tuberculosis Conserved protein 0.0037 0.0331 0.0943
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0016 0.0043
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0369 0.0724
Giardia lamblia Cathepsin B precursor 0.0091 0.1116 0.257
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0746 0.1968
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.0746 0.1687
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0281 0.0505
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.0606
Onchocerca volvulus 0.0049 0.0504 0.0893
Schistosoma mansoni jumonji/arid domain-containing protein 0.0169 0.224 0.2215
Loa Loa (eye worm) hypothetical protein 0.0037 0.0331 0.0873
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0293 0.0534
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0281 0.2453
Echinococcus multilocularis lysine specific demethylase 5A 0.0164 0.218 0.2155
Brugia malayi beta-lactamase family protein 0.0037 0.0331 0.0873
Trichomonas vaginalis esterase, putative 0.0037 0.0331 0.0629
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.4263 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0032 0.0085
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0077 0.014
Echinococcus granulosus bloom syndrome protein 0.0022 0.0114 0.0083
Echinococcus multilocularis JmjC domain containing protein 4 0.0044 0.0434 0.0403
Trypanosoma brucei unspecified product 0.0027 0.0192 0.0378
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0077 0.1108
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0775 0.1754
Plasmodium vivax SET domain protein, putative 0.003 0.024 0.5407
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0331 0.0943
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0226 0.307 0.3047
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0504 0.0473
Loa Loa (eye worm) hypothetical protein 0.0044 0.0434 0.1144
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0032 0.0084
Loa Loa (eye worm) hypothetical protein 0.0085 0.1033 0.2727
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0114 0.0301
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0032 0.0481
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0091 0.1116 0.2561
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.4119 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.0935 0.0906
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0331 0.0706
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0536 0.1413
Loa Loa (eye worm) hypothetical protein 0.0037 0.0331 0.0873
Brugia malayi cathepsin B-like cysteine proteinase 0.0276 0.379 1
Brugia malayi jmjC domain containing protein 0.0169 0.224 0.5911
Loa Loa (eye worm) hypothetical protein 0.0154 0.2035 0.5368
Loa Loa (eye worm) hypothetical protein 0.0065 0.0746 0.1968
Echinococcus granulosus cathepsin b 0.0276 0.379 0.377
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.024 0.0209
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0077 0.0045
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0032 0.0206
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0281 0.0588
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0048 0.0016
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0338 0.0307
Loa Loa (eye worm) hypothetical protein 0.0044 0.0434 0.1144
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0369 0.0338
Echinococcus multilocularis phd:f box containing protein 0.0044 0.0434 0.0403
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.023 0.0198
Echinococcus granulosus fetal alzheimer antigen falz 0.0049 0.0511 0.0481
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.4119 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0077 0.0105
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0601 0.0571
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.1023 0.0994
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0364 0.0333
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.0511 0.0481
Plasmodium falciparum JmjC domain-containing protein, putative 0.0044 0.0434 1
Schistosoma mansoni jumonji domain containing protein 0.0044 0.0434 0.0403
Echinococcus granulosus peregrin 0.0035 0.0305 0.0274
Schistosoma mansoni hypothetical protein 0.003 0.023 0.0198
Loa Loa (eye worm) hypothetical protein 0.0055 0.0601 0.1587
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0044 0.0434 0.0949
Echinococcus multilocularis zinc finger protein 0.0043 0.0418 0.0387
Toxoplasma gondii ABC1 family protein 0.0037 0.0331 0.2906
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0399 0.0368
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0369 0.0974
Schistosoma mansoni hypothetical protein 0.0085 0.1023 0.0994
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1909 0.5927
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0369 0.0338
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0276 0.379 0.377
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.024 0.2084
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0369 0.0797
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0077 0.0203
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0536 0.1413
Loa Loa (eye worm) hypothetical protein 0.0049 0.0504 0.133
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0048 0.0494 0.0464
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.4119 1
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0114 0.0093
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0504 0.0473
Mycobacterium tuberculosis Conserved protein 0.0037 0.0331 0.0943
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0048 0.0494 0.0464
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0504 0.0473
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0303 0.0798
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0331 0.0943
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0331 0.0706
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0434 0.1144
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0451 0.119
Mycobacterium ulcerans beta-lactamase 0.0037 0.0331 0.1226
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0044 0.0434 0.3834
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0427 0.0932
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0369 0.1411
Schistosoma mansoni apoptosis regulator bax 0.0085 0.1023 0.0994
Schistosoma mansoni microtubule-associated protein tau 0.0705 1 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1023 0.2699
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0293 0.0772
Loa Loa (eye worm) RecQ helicase 0.0022 0.0114 0.0301
Echinococcus multilocularis microtubule associated protein 2 0.0705 1 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1912 0.4442
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.3199 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.4119 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0091 0.1116 0.2561
Echinococcus multilocularis dna polymerase eta 0.0065 0.0746 0.0716
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0369 0.0797
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0331 0.0629
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.2634 0.261
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0689 0.1817
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Echinococcus granulosus zinc finger protein 0.0043 0.0418 0.0387
Brugia malayi Bromodomain containing protein 0.0035 0.0305 0.0804
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0049 0.0511 0.0481
Loa Loa (eye worm) hypothetical protein 0.0051 0.0536 0.1413
Echinococcus granulosus dna polymerase kappa 0.0039 0.0369 0.0338
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0331 0.7564
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0032 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0779 0.075
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0114 0.0093
Echinococcus granulosus phd:f box containing protein 0.0044 0.0434 0.0403
Brugia malayi jmjC domain containing protein 0.0044 0.0434 0.1144
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0091 0.1116 0.257
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0331 0.0873
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.1023 0.0994
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0775 0.1754
Loa Loa (eye worm) jmjC domain-containing protein 0.0169 0.224 0.5911
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0775 0.0745
Loa Loa (eye worm) hypothetical protein 0.0089 0.1087 0.2867
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.2634 0.261
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.1912 0.4442
Schistosoma mansoni jumonji domain containing protein 0.0206 0.278 0.2756
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0331 0.0629
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0779 0.075
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0077 0.0105
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0331 0.03
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0331 0.0629
Trichomonas vaginalis rotamase, putative 0.0033 0.0281 0.0505
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0276 0.379 0.377
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0427 0.0932
Schistosoma mansoni ap endonuclease 0.0019 0.0077 0.0045
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0091 0.1116 0.1087
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0331 0.0943
Trypanosoma cruzi ISWI complex protein 0.0033 0.0282 0.0591
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0133
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0775 0.1726
Loa Loa (eye worm) hypothetical protein 0.0037 0.0331 0.0873
Schistosoma mansoni hypothetical protein 0.0085 0.1023 0.0994
Mycobacterium ulcerans hypothetical protein 0.0037 0.0331 0.1226
Echinococcus granulosus expressed protein 0.0034 0.0293 0.0261
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0564 0.1256
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0601 0.1587
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0369 0.1411
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0084
Echinococcus multilocularis cathepsin b 0.0276 0.379 0.377
Schistosoma mansoni hypothetical protein 0.0045 0.0451 0.042
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0369 0.0797
Toxoplasma gondii exonuclease III APE 0.0019 0.0077 0.0608
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0775 0.0745
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0192 0.0378
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1912 0.4442
Giardia lamblia PHD finger protein 15 0.003 0.023 0.0378
Leishmania major mitochondrial DNA polymerase beta 0.0308 0.4263 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0032 0.0084
Echinococcus multilocularis expressed protein 0.0034 0.0293 0.0261
Brugia malayi Pre-SET motif family protein 0.003 0.024 0.0633
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.1023 0.2699
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0775 0.1754
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0504 0.0473
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0331 0.03
Loa Loa (eye worm) hypothetical protein 0.0037 0.0331 0.0873
Giardia lamblia Cathepsin B precursor 0.0091 0.1116 0.257
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0281 0.0588
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0369 0.1064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.4119 1
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0399 0.0368
Leishmania major DNA polymerase eta, putative 0.0038 0.0352 0.0757
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.1023 0.0994
Schistosoma mansoni hypothetical protein 0.0085 0.1023 0.0994
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0338 0.0307
Mycobacterium ulcerans hypothetical protein 0.0162 0.215 1
Plasmodium vivax JmjC domain containing protein 0.0044 0.0434 1
Brugia malayi PHD-finger family protein 0.003 0.023 0.0606
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0775 0.0745
Brugia malayi mbt repeat family protein 0.0049 0.0504 0.133
Giardia lamblia Fructose-bisphosphate aldolase 0.0298 0.4119 1
Echinococcus granulosus jumonji domain containing 1A 0.0044 0.0434 0.0403
Echinococcus multilocularis peregrin 0.0035 0.0305 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0192 0.0378
Schistosoma mansoni hypothetical protein 0.0033 0.0282 0.0251
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0077 0.0045
Schistosoma mansoni bromodomain containing protein 0.0138 0.1799 0.1773
Onchocerca volvulus 0.0037 0.0331 0.033
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0369 0.0338
Schistosoma mansoni protein phosphatase 2C 0.0044 0.0434 0.0403
Treponema pallidum fructose-bisphosphate aldolase 0.0298 0.4119 1
Giardia lamblia DINP protein human, muc B family 0.0039 0.0369 0.0724
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0331 0.1226
Trypanosoma brucei unspecified product 0.0027 0.0192 0.0378
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0044 0.0434 0.0403
Loa Loa (eye worm) hypothetical protein 0.0037 0.0331 0.0873
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0192 0.0378
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0601 0.0571
Trypanosoma brucei ISWI complex protein 0.0033 0.0282 0.0591
Giardia lamblia Cathepsin B precursor 0.0091 0.1116 0.257
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0504 0.0893
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0331 0.0943
Echinococcus multilocularis cathepsin b 0.0276 0.379 0.377
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0504 0.133
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.013 0.1686 0.166
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0434 0.1144
Schistosoma mansoni hypothetical protein 0.03 0.4141 0.4123
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0352 0.0757
Echinococcus multilocularis jumonji domain containing 1A 0.0044 0.0434 0.0403
Brugia malayi jmjC domain containing protein 0.0226 0.307 0.81
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0226 0.307 0.3047
Schistosoma mansoni rotamase 0.0034 0.0293 0.0261
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.4119 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0338 0.0307
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.1023 0.0994
Brugia malayi Bromodomain containing protein 0.0164 0.217 0.5725
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.0779 0.075
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0077 0.0105
Onchocerca volvulus 0.0037 0.0331 0.033
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0044 0.0434 0.3834
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0331 0.0629
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.013 0.1686 0.166
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0775 0.1754
Loa Loa (eye worm) MBCTL1 0.0055 0.0601 0.1587
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0293 0.0772
Echinococcus granulosus JmjC domain containing protein 4 0.0044 0.0434 0.0403
Mycobacterium tuberculosis Conserved protein 0.0037 0.0331 0.0943
Brugia malayi jmjC domain containing protein 0.0044 0.0434 0.1144
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.4119 1
Toxoplasma gondii hypothetical protein 0.005 0.0519 0.4604
Loa Loa (eye worm) cathepsin B 0.0091 0.1116 0.2944
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0369 0.0797
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0364 0.0333
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0331 0.0706
Toxoplasma gondii cathepsin B 0.0091 0.1116 1
Schistosoma mansoni DNA polymerase eta 0.0065 0.0746 0.0716
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.023 0.0198
Echinococcus multilocularis lysine specific demethylase 6a 0.0044 0.0434 0.0403
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0281 0.0588
Onchocerca volvulus 0.0037 0.0331 0.033
Leishmania major DNA polymerase eta, putative 0.0065 0.0746 0.1687
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0504 0.0473
Leishmania major hypothetical protein, conserved 0.0037 0.0331 0.0706
Trichomonas vaginalis rotamase, putative 0.0034 0.0293 0.0534
Trypanosoma brucei unspecified product 0.0039 0.0369 0.0797
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.1023 0.0994
Brugia malayi jmjC domain containing protein 0.0044 0.0434 0.1144
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.215 0.6688
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0331 0.0943
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0434 0.1144
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.0779 0.075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.4119 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0369 0.0338
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.1023 0.2699
Echinococcus granulosus cathepsin b 0.0276 0.379 0.377
Loa Loa (eye worm) hypothetical protein 0.0035 0.0303 0.0798

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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