Detailed information for compound 695288

Basic information

Technical information
  • TDR Targets ID: 695288
  • Name: methyl 2-(9-cyclohexyl-1,7-dimethyl-2,4-dioxo -7,8-dihydro-6H-purino[7,8-a]pyrimidin-3-yl)a cetate
  • MW: 389.449 | Formula: C19H27N5O4
  • H donors: 0 H acceptors: 4 LogP: 2.26 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)Cn1c(=O)n(C)c2c(c1=O)n1CC(C)CN(c1n2)C1CCCCC1
  • InChi: 1S/C19H27N5O4/c1-12-9-22(13-7-5-4-6-8-13)18-20-16-15(23(18)10-12)17(26)24(11-14(25)28-3)19(27)21(16)2/h12-13H,4-11H2,1-3H3
  • InChiKey: UDXQNJSPDUEUQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(9-cyclohexyl-1,7-dimethyl-2,4-dioxo-7,8-dihydro-6H-purino[7,8-a]pyrimidin-3-yl)acetic acid methyl ester
  • 2-(9-cyclohexyl-2,4-diketo-1,7-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidin-3-yl)acetic acid methyl ester
  • methyl 2-(9-cyclohexyl-1,7-dimethyl-2,4-dioxo-7,8-dihydro-6H-purino[7,8-a]pyrimidin-3-yl)ethanoate
  • BAS 12521478

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax acyl-CoA synthetase, putative 0.0062 0.0323 0.4418
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0453 0.0944
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0016 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Treponema pallidum licC protein (licC) 0.0117 0.0671 1
Schistosoma mansoni hypothetical protein 0.0016 0.0041 0.0041
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0096 0.0054
Echinococcus granulosus L aminoadipate semialdehyde 0.0094 0.0525 0.0486
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0091 0.0485
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0016 0.0041 0.0171
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0278 0.1618
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0323 0.0282
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0083 0.034
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0453 0.2697
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0016 0.0041 0.0182
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0024 0.0091 0.0456
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0276 0.1607
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0096 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0343 0.3852
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0033 0.0147 0.1911
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0034 0.00000000096718
Echinococcus granulosus bloom syndrome protein 0.0023 0.0083 0.0042
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0016 0.0041 0.0182
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0091 0.0931
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.0671 0.1559
Leishmania major DNA polymerase kappa, putative 0.009 0.0503 0.5899
Leishmania major DNA polymerase eta, putative 0.0142 0.0823 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0083 0.0456 0.2708
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0076 0.0229
Echinococcus granulosus dnaJ subfamily B 0.0947 0.5833 0.5815
Schistosoma mansoni transient receptor potential channel 0.0016 0.0041 0.0041
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0049 0.0008
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0323 0.0282
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0278 0.0278
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0278 0.0278
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0217 0.129 0.1254
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0013 0.0013
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0091 0.0959
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0288 0.315
Trypanosoma brucei chrX additional, unordered contigs 0.0026 0.0101 0.0757
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0083 0.1305
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0105 0.0075
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0024 0.0091 0.0039
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0016 0.0041 0.0041
Loa Loa (eye worm) voltage-gated potassium channel 0.0016 0.0041 0.0171
Trypanosoma cruzi DNA damage repair protein, putative 0.0026 0.0101 0.1077
Mycobacterium ulcerans acetyl-CoA synthetase 0.0024 0.0091 0.0039
Schistosoma mansoni pyruvate kinase 0.0019 0.0061 0.0061
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0083 0.0428
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.0096 0.0694
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0083 0.0042
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.0091 0.0054
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Schistosoma mansoni voltage-gated ion channel 0.0016 0.0041 0.0041
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0091 0.0635
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Onchocerca volvulus 0.0024 0.0091 0.1025
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0016 0.0041 0.0182
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0083 0.0806
Giardia lamblia DINP protein human, muc B family 0.009 0.0503 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.0671 0.1559
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0096 0.0694
Onchocerca volvulus 0.0024 0.0091 0.1025
Echinococcus multilocularis pyruvate kinase 0.0019 0.0061 0.002
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0105 0.0037
Schistosoma mansoni voltage-gated cation channel 0.0016 0.0041 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0453 0.0993
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0175 0.2314
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0043 0.0002
Leishmania major DNA polymerase kappa, putative 0.0026 0.0101 0.0757
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0016 0.0041 0.0182
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0083 0.0439
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0105 0.067
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0024 0.0091 0.1442
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0025 0.0096 0.0054
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0016 0.0041 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0125 0.0719 0.8664
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0016 0.0041 0.0041
Schistosoma mansoni acetyl-CoA synthetase 0.0024 0.0091 0.0091
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0016 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0062 0.0323 0.1897
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0024 0.0091 0.005
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.0041 0.0041
Echinococcus multilocularis calcium activated potassium channel 0.0017 0.0045 0.0003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0091 0.0475
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0091 0.0485
Trypanosoma brucei DNA polymerase eta, putative 0.0142 0.0823 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0024 0.0091 0.0039
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0175 0.2306
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0101 0.0757
Onchocerca volvulus 0.0082 0.0453 0.8505
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0025 0.0096 0.0514
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0016 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0094 0.0525 0.3131
Schistosoma mansoni hypothetical protein 0.0392 0.2382 0.2382
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0453 0.2697
Echinococcus granulosus leucine aminopeptidase protein 0.0125 0.0719 0.068
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0091 0.0475
Loa Loa (eye worm) RecQ helicase 0.0023 0.0083 0.0428
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0049 0.0008
Schistosoma mansoni DNA helicase recq1 0.0023 0.0083 0.0083
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0013 0.005
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0113 0.0643 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0076 0.0775
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0076 0.0444
Loa Loa (eye worm) CXXC zinc finger family protein 0.0067 0.0354 0.2085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0276 0.0236
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0083 0.0806
Echinococcus multilocularis pyruvate kinase 0.0019 0.0061 0.002
Plasmodium falciparum pyruvate kinase 0.0038 0.0175 0.1736
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0096 0.0694
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0016 0.0041 0.0346
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0024 0.0091 0.0039
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0062 0.0323 0.3559
Loa Loa (eye worm) hypothetical protein 0.0056 0.0288 0.1677
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0034 0.00000000096718
Loa Loa (eye worm) hypothetical protein 0.0061 0.0323 0.1891
Schistosoma mansoni cpg binding protein 0.007 0.0378 0.0378
Schistosoma mansoni pyruvate kinase 0.0038 0.0175 0.0175
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0453 0.0979
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0016 0.0041 0.0182
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0016 0.0041 0.0182
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0091 0.0039
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0041 0.0431
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0343 0.3852
Echinococcus multilocularis dna polymerase eta 0.0142 0.0823 0.0785
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0082 0.0453 0.0979
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0016 0.0041 0.0171
Toxoplasma gondii histone lysine methyltransferase SET1 0.0126 0.0724 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0091 0.0054
Loa Loa (eye worm) voltage-gated potassium channel 0.0016 0.0041 0.0171
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0175 0.2325
Schistosoma mansoni microtubule-associated protein tau 0.1617 1 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0175 0.1
Echinococcus multilocularis microtubule associated protein 2 0.1617 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0091 0.0039
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0091 0.0959
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0016 0.0041 0.0041
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0105 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0288 0.315
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0067 0.0338
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Loa Loa (eye worm) hypothetical protein 0.0062 0.0323 0.1897
Leishmania major DNA damage repair protein, putative 0.0026 0.0101 0.0757
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0091 0.0485
Trypanosoma cruzi DNA damage repair protein, putative 0.0026 0.0101 0.1077
Brugia malayi CXXC zinc finger family protein 0.0067 0.0354 0.2094
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0323 0.0323
Onchocerca volvulus 0.0094 0.0525 1
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0175 0.2765
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0175 0.099
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0025 0.0096 0.0514
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0083 0.102
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0096 0.0054
Loa Loa (eye worm) hypothetical protein 0.0082 0.0453 0.2689
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0453 0.0979
Echinococcus granulosus pyruvate kinase 0.0038 0.0175 0.0134
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0043 0.0002
Schistosoma mansoni hypothetical protein 0.0332 0.2007 0.2007
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0125 0.0719 0.871
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Entamoeba histolytica deoxycytidyl transferase, putative 0.0083 0.0456 0.7989
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Schistosoma mansoni transient receptor potential channel 4 0.0016 0.0041 0.0041
Brugia malayi Cyclic-nucleotide gated cation channel 0.0016 0.0041 0.0182
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0069 0.0027
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0082 0.0453 0.0979
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.0096 0.1016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.00000000036017
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0083 0.0042
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0025 0.0096 0.0503
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0175 0.1712
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.0091 0.0054
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0643 0.7698
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0083 0.0537
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0101 0.1077
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0276 0.0236
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0125 0.0719 0.1637
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0083 0.0456 0.0456
Trypanosoma brucei DNA polymerase IV, putative 0.0113 0.0643 0.7698
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.009 0.0503 0.1122
Mycobacterium ulcerans hypothetical protein 0.0117 0.0671 0.1546
Trypanosoma brucei unspecified product 0.0105 0.0597 0.7104
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0101 0.0757
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0069 0.0338
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0076 0.0384
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0016 0.0041 0.0182
Echinococcus granulosus dna polymerase kappa 0.0113 0.0643 0.0604
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0643 0.7698
Entamoeba histolytica hypothetical protein 0.0026 0.0105 0.1694
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0105 0.0091
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0083 0.0439
Loa Loa (eye worm) voltage-dependent calcium channel 0.0016 0.0041 0.0171
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0101 0.0568 0.674
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0076 0.0444
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0024 0.0091 0.1127
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0083 0.034
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0641 0.3925 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0091 0.0931
Echinococcus granulosus short transient receptor potential channel 6 0.0017 0.0049 0.0008
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0062 0.0323 0.0657
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0125 0.0719 0.8664
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0024 0.0091 0.0039
Schistosoma mansoni calcium-activated potassium channel 0.0016 0.0041 0.0041
Entamoeba histolytica acyl-coA synthetase, putative 0.0082 0.0453 0.7932
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0104 0.0556
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0641 0.3925 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0453 0.0979
Loa Loa (eye worm) hypothetical protein 0.0024 0.0091 0.0475
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0091 0.0039
Schistosoma mansoni cpg binding protein 0.0067 0.0354 0.0354
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0076 0.0686
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0643 0.7698
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0105 0.0075
Loa Loa (eye worm) hypothetical protein 0.0024 0.0091 0.0475
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0091 0.0039
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0276 0.0236
Trypanosoma brucei unspecified product 0.0057 0.0296 0.3259
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0276 0.0236
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0175 0.1999
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0641 0.3925 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0061 0.002
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0091 0.0039
Onchocerca volvulus 0.0024 0.0091 0.1025
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0323 0.19
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0013 0.0039
Loa Loa (eye worm) hypothetical protein 0.0062 0.0323 0.1897
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Loa Loa (eye worm) hypothetical protein 0.0082 0.0453 0.2689
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Trypanosoma brucei DNA damage repair protein, putative 0.0026 0.0101 0.0757
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0091 0.0959
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0105 0.0814
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.0091 0.0054
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0016 0.0041 0.0116
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0125 0.0719 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0096 0.0694
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0303 0.0603
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0016 0.0041 0.0182
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0091 0.0054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0034 0.00000000096718
Trypanosoma cruzi DNA polymerase eta, putative 0.0142 0.0823 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0026 0.0101 0.0602
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0276 0.4849
Schistosoma mansoni leucine aminopeptidase 0.0025 0.0096 0.0096
Schistosoma mansoni terminal deoxycytidyl transferase 0.0083 0.0456 0.0456
Schistosoma mansoni vesicular amine transporter 0.0016 0.0041 0.0041
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0175 0.0273
Schistosoma mansoni ryanodine receptor related 0.0016 0.0041 0.0041
Onchocerca volvulus 0.0024 0.0091 0.1025
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0083 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0278 0.0278
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0083 0.0042
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0083 0.0456 0.0416
Schistosoma mansoni DNA polymerase IV / kappa 0.0026 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.01 0.0565 0.3374
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0091 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Toxoplasma gondii propionate-CoA ligase 0.0024 0.0091 0.1127
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0276 0.0276
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0643 0.7698
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0016 0.0041 0.0182
Schistosoma mansoni two-pore calcium channel 0.0016 0.0041 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0303 0.0603
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0323 0.0282
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0016 0.0041 0.0041
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0024 0.0091 0.0054
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0016 0.0041 0.0182
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0025 0.0096 0.0514
Toxoplasma gondii leucyl aminopeptidase LAP 0.0125 0.0719 0.9919
Loa Loa (eye worm) hypothetical protein 0.01 0.0565 0.3374
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0105 0.0814
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0016 0.0041 0.0041
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0175 0.2314
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Schistosoma mansoni DNA polymerase eta 0.0142 0.0823 0.0823
Brugia malayi follicle stimulating hormone receptor 0.0274 0.1648 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0453 0.7932
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0175 0.1
Onchocerca volvulus 0.0054 0.0276 0.4849
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0453 0.7932
Plasmodium falciparum M17 leucyl aminopeptidase 0.0125 0.0719 1
Brugia malayi cytosol aminopeptidase 0.0025 0.0096 0.0514
Brugia malayi Transient-receptor-potential like protein 0.0016 0.0041 0.0182
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0091 0.0039
Loa Loa (eye worm) hypothetical protein 0.0142 0.0823 0.4953
Brugia malayi olfactory channel protein osm-9 0.0017 0.0049 0.0229
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0105 0.1323
Echinococcus multilocularis cpg binding protein 0.007 0.0378 0.0338
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0034 0.00000000096718
Echinococcus multilocularis dnaJ subfamily B 0.0947 0.5833 0.5815
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0091 0.0039
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0016 0.0041 0.0116
Trypanosoma brucei DNA damage repair protein, putative 0.0026 0.0101 0.0757
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0091 0.0485
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0076 0.0035
Loa Loa (eye worm) ryanodine receptor 0.0016 0.0041 0.0171
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0016 0.0041 0.0182
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0083 0.102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0278 0.0237
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0643 0.7778
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0082 0.0453 0.0993
Echinococcus multilocularis pyruvate kinase 0.0038 0.0175 0.0134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0643 0.7778
Loa Loa (eye worm) oxidoreductase 0.0024 0.0091 0.0475
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0016 0.0041 0.0182
Echinococcus multilocularis pyruvate kinase 0.0019 0.0061 0.002
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0016 0.0041 0.0346
Echinococcus multilocularis L aminoadipate semialdehyde 0.0094 0.0525 0.0486
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0643 0.7698
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0125 0.0719 0.1669
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0076 0.1174
Chlamydia trachomatis cytosol aminopeptidase 0.0125 0.0719 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0105 0.1393
Echinococcus granulosus pyruvate kinase 0.0019 0.0061 0.002
Toxoplasma gondii transporter, cation channel family protein 0.0016 0.0041 0.0431
Chlamydia trachomatis pyruvate kinase 0.0038 0.0175 0.1143
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0141 0.0818 0.0818
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0082 0.0453 0.0979
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0076 0.0394
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0453 0.5265
Schistosoma mansoni pyruvate kinase 0.0038 0.0175 0.0175
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0323 0.0282
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0091 0.0635
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0013 0.0039
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0175 0.1999
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.0096 0.0694
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0016 0.0041 0.0182
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0076 0.0035
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0091 0.0635
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0083 0.0456 0.0416
Trypanosoma brucei DNA polymerase IV, putative 0.0105 0.0597 0.7104
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0049 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0218
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0175 0.1712
Schistosoma mansoni cpg binding protein 0.007 0.0378 0.0378
Mycobacterium ulcerans hypothetical protein 0.0117 0.0671 0.1546
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0024 0.0091 0.1127
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Brugia malayi mbt repeat family protein 0.0054 0.0276 0.1616
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Schistosoma mansoni ap endonuclease 0.0022 0.0076 0.0076
Plasmodium vivax acetyl-CoA synthetase, putative 0.0024 0.0091 0.1136
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0016 0.0041 0.0041
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0026 0.0101 0.1261
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0061 0.0706
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0085 0.0468 0.6402
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0428
Schistosoma mansoni hypothetical protein 0.0947 0.5833 0.5833
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0024 0.0091 0.0039
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0016 0.0041 0.0041
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0061 0.0712
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0024 0.0091 0.0635
Schistosoma mansoni ap endonuclease 0.0022 0.0076 0.0076
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0083 0.0806
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0016 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0062 0.0323 0.1897
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0083 0.0865
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0101 0.1077
Echinococcus granulosus dna polymerase eta 0.0142 0.0823 0.0785
Echinococcus granulosus pyruvate kinase 0.0019 0.0061 0.002
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0083 0.0042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0643 0.7778
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.0568 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0043 0.0043
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0175 0.2765
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0011 0.0011
Plasmodium falciparum acyl-CoA synthetase 0.0062 0.0323 0.399
Toxoplasma gondii exonuclease III APE 0.0022 0.0076 0.0918
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0278 0.1627
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0096 0.0054
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0082 0.0453 0.0979
Schistosoma mansoni hypothetical protein 0.0392 0.2382 0.2382
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0091 0.0485
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0453 0.0944
Brugia malayi Protein kinase domain containing protein 0.0101 0.0568 0.3401
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0076 0.0686
Toxoplasma gondii hypothetical protein 0.0016 0.0041 0.0431
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0278 0.0237
Loa Loa (eye worm) hypothetical protein 0.0054 0.0276 0.1607
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0062 0.0323 0.0642
Echinococcus granulosus calcium activated potassium channel 0.0017 0.0045 0.0003
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0041 0.0431
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0091 0.0054
Loa Loa (eye worm) hypothetical protein 0.0038 0.0175 0.099
Mycobacterium ulcerans DNA polymerase IV 0.0113 0.0643 0.1473
Brugia malayi hypothetical protein 0.0016 0.0041 0.0182
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0034 0.00000000096718
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0101 0.0568 0.3394
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0076 0.0775
Entamoeba histolytica hypothetical protein 0.0101 0.0568 1
Entamoeba histolytica protein kinase, putative 0.0101 0.0568 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0076 0.0016
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0276 0.0276
Brugia malayi voltage-dependent calcium channel 0.0016 0.0041 0.0182
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0096 0.0694
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0043 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0453 0.5265
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0343 0.3852
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0076 0.0953
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0303 0.0603
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0025 0.0096 0.0096
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0016 0.0041 0.0171
Brugia malayi cation channel family protein 0.0016 0.0041 0.0182
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0083 0.0439
Trypanosoma brucei unspecified product 0.0057 0.0296 0.3259
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0024 0.0091 0.0039
Toxoplasma gondii transporter, cation channel family protein 0.0016 0.0041 0.0431
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0016 0.0041 0.0182
Echinococcus multilocularis leucine aminopeptidase protein 0.0125 0.0719 0.068
Loa Loa (eye worm) hypothetical protein 0.0082 0.0453 0.2689
Leishmania major pyruvate kinase 0.0038 0.0175 0.1712
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0069 0.0027
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.0041 0.0041
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0091 0.0054
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0171
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0643 0.7778
Toxoplasma gondii transporter, cation channel family protein 0.0016 0.0041 0.0431
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0643 0.7698
Mycobacterium ulcerans hypothetical protein 0.0026 0.0101 0.0064
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.0568 0.6853
Leishmania major DNA polymerase eta, putative 0.0085 0.0468 0.5452
Giardia lamblia DNA damage repair protein 0.0026 0.0101 0.0897
Schistosoma mansoni DNA helicase recq5 0.0023 0.0083 0.0083
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0083 0.0507
Echinococcus multilocularis pyruvate kinase 0.0038 0.0175 0.0134
Schistosoma mansoni transient receptor potential channel 0.0017 0.0049 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0453 0.2697
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0091 0.0054
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0125 0.0719 0.1682
Brugia malayi mbt repeat family protein 0.0054 0.0276 0.1616
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.0091 0.0054
Brugia malayi cation channel family protein 0.0016 0.0041 0.0182
Plasmodium vivax DNA repair protein REV1, putative 0.0026 0.0101 0.1271
Loa Loa (eye worm) ion channel NompC 0.0016 0.0041 0.0171
Mycobacterium ulcerans DNA polymerase IV 0.0113 0.0643 0.1473
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0125 0.0719 0.871
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0034 0.00000000096718
Leishmania major pyruvate kinase 0.0038 0.0175 0.1712
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0094 0.0525 0.0525
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.0568 0.6853
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0175 0.0257
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.0096 0.1016
Echinococcus multilocularis dual specificity 0.0101 0.0568 0.0529
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0101 0.0568 0.674
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0303 0.0603
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0034 0.00000000096718
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0091 0.0635
Onchocerca volvulus 0.0067 0.0354 0.6466
Echinococcus multilocularis pyruvate kinase 0.003 0.0126 0.0085
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0043 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0278 0.0237
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0217 0.129 0.1254
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0175 0.099
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0091 0.0039
Echinococcus multilocularis dna polymerase kappa 0.0113 0.0643 0.0604
Mycobacterium tuberculosis Conserved hypothetical protein 0.0083 0.0456 0.1001
Brugia malayi ion channel NompC 0.0016 0.0041 0.0182
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Toxoplasma gondii hypothetical protein 0.0016 0.0041 0.0431
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0503 0.5899
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0024 0.0091 0.0485
Echinococcus granulosus pyruvate kinase 0.0038 0.0175 0.0134
Loa Loa (eye worm) hypothetical protein 0.0062 0.0323 0.1897
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0643 0.7698
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.0041 0.0041
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.0041 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0278 0.0237
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0104 0.1679
Brugia malayi ImpB/MucB/SamB family protein 0.0142 0.0823 0.4958
Schistosoma mansoni voltage-dependent calcium channel 0.0016 0.0041 0.0041
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0105 0.1334
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0643 0.7698
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0083 0.0537
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0105 0.1323
Echinococcus granulosus geminin 0.0392 0.2382 0.235
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0034 0.00000000096718
Loa Loa (eye worm) voltage-gated calcium channel 0.0016 0.0041 0.0171
Echinococcus granulosus cpg binding protein 0.007 0.0378 0.0338
Trypanosoma cruzi DNA polymerase eta, putative 0.0085 0.0468 0.5609
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0024 0.0091 0.0039
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0025 0.0096 0.0503
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0076 0.0342
Trypanosoma brucei DNA polymerase IV, putative 0.0113 0.0643 0.7698
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0453 0.5265
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0016 0.0041 0.0041
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0274 0.1648 1
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0175 0.099
Loa Loa (eye worm) MBCTL1 0.0061 0.0323 0.1891
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Brugia malayi polk-prov protein 0.0056 0.0288 0.1687
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0643 0.7698
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0096 0.0054
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.009 0.0503 0.5899
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0117 0.0671 0.1546
Entamoeba histolytica protein kinase, putative 0.0101 0.0568 1
Brugia malayi ImpB/MucB/SamB family protein 0.0083 0.0456 0.2716
Loa Loa (eye worm) calcium channel 0.0016 0.0041 0.0171
Giardia lamblia Pyruvate kinase 0.0038 0.0175 0.2586
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0024 0.0091 0.0054
Mycobacterium ulcerans leucyl aminopeptidase 0.0125 0.0719 0.1669
Echinococcus multilocularis short transient receptor potential channel 6 0.0017 0.0049 0.0008
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0641 0.3925 1
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Schistosoma mansoni 60S ribosomal protein L21 0.0016 0.0041 0.0041
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0094 0.0525 0.3139
Echinococcus multilocularis geminin 0.0392 0.2382 0.235
Echinococcus granulosus dual specificity 0.0101 0.0568 0.0529
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0175 0.022
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0117 0.0671 0.9256
Schistosoma mansoni transient receptor potential channel 0.0016 0.0041 0.0041
Mycobacterium ulcerans hypothetical protein 0.0082 0.0453 0.0979
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0041 0.0041
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0016 0.0041 0.0182
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0076 0.0925
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0568 0.0568
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0024 0.0091 0.005
Trichomonas vaginalis DNA polymerase eta, putative 0.0113 0.0643 1
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0175 0.2765
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0556
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0091 0.0959

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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