Detailed information for compound 695312

Basic information

Technical information
  • TDR Targets ID: 695312
  • Name: 1-methyl-9-(phenylmethyl)-3-prop-2-enyl-7,8-d ihydro-6H-purino[8,7-b]pyrimidine-2,4-dione
  • MW: 351.402 | Formula: C19H21N5O2
  • H donors: 0 H acceptors: 3 LogP: 2.23 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCn1c(=O)n(C)c2c(c1=O)n1CCCN(c1n2)Cc1ccccc1
  • InChi: 1S/C19H21N5O2/c1-3-10-24-17(25)15-16(21(2)19(24)26)20-18-22(11-7-12-23(15)18)13-14-8-5-4-6-9-14/h3-6,8-9H,1,7,10-13H2,2H3
  • InChiKey: RCHJQCPYRFRCPW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-allyl-1-methyl-9-(phenylmethyl)-7,8-dihydro-6H-purino[8,7-b]pyrimidine-2,4-dione
  • 3-allyl-9-(benzyl)-1-methyl-7,8-dihydro-6H-purino[8,7-b]pyrimidine-2,4-quinone
  • ZINC04249248
  • BAS 12521329

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii leucyl aminopeptidase LAP 0.0125 0.0709 0.9919
Schistosoma mansoni acetyl-CoA synthetase 0.0024 0.008 0.008
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0071 0.0401
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0095 0.0037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0024 0.00000000096718
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0025 0.0085 0.0486
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0071 0.0846
Echinococcus granulosus pyruvate kinase 0.0021 0.0059 0.0026
Schistosoma mansoni DNA polymerase IV / kappa 0.0026 0.009 0.009
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0181 0.1071
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.008 0.0054
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0073 0.004
Loa Loa (eye worm) hypothetical protein 0.0082 0.0443 0.2689
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0141 0.0808 0.0808
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.008 0.0959
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0058 0.0025
Toxoplasma gondii propionate-CoA ligase 0.0024 0.008 0.1127
Loa Loa (eye worm) pyruvate kinase 0.004 0.0181 0.1088
Loa Loa (eye worm) hypothetical protein 0.0082 0.0443 0.2689
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0312 0.028
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0071 0.0039
Giardia lamblia DINP protein human, muc B family 0.009 0.0492 1
Schistosoma mansoni DNA helicase recq5 0.0023 0.0073 0.0073
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0071 0.1041
Giardia lamblia DNA damage repair protein 0.0026 0.009 0.0724
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0312 0.028
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0073 0.0806
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0266 0.0266
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0266 0.1607
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0443 0.0965
Schistosoma mansoni pyruvate kinase 0.004 0.0181 0.0181
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.008 0.0054
Mycobacterium ulcerans DNA polymerase IV 0.0113 0.0633 0.146
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0217 0.1282 0.1253
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0028 0.0105 0.0624
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.0457
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0277 0.2776
Echinococcus multilocularis dna polymerase kappa 0.0113 0.0633 0.0602
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0024 0.00000000096718
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0428
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0024 0.008 0.0123
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0094 0.0515 0.0515
Trypanosoma cruzi DNA damage repair protein, putative 0.0026 0.009 0.1077
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0125 0.0709 0.8591
Trichomonas vaginalis DNA polymerase eta, putative 0.0113 0.0633 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0033 0.0137 0.1911
Brugia malayi cytosol aminopeptidase 0.0025 0.0085 0.0486
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0332 0.3516
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0266 0.0266
Echinococcus multilocularis dna polymerase eta 0.0142 0.0813 0.0783
Loa Loa (eye worm) hypothetical protein 0.004 0.0181 0.1088
Brugia malayi follicle stimulating hormone receptor 0.0274 0.1639 1
Giardia lamblia Pyruvate kinase 0.004 0.0181 0.2815
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0073 0.004
Loa Loa (eye worm) hypothetical protein 0.0082 0.0443 0.2689
Mycobacterium ulcerans hypothetical protein 0.0117 0.0661 0.1533
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0085 0.0186
Loa Loa (eye worm) hypothetical protein 0.0142 0.0813 0.4953
Leishmania major DNA polymerase kappa, putative 0.009 0.0492 0.5675
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0125 0.0709 0.1682
Onchocerca volvulus 0.0054 0.0266 0.4261
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0082 0.0443 0.0965
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0024 0.008 0.0024
Echinococcus granulosus dna polymerase eta 0.0142 0.0813 0.0783
Echinococcus multilocularis pyruvate kinase 0.0021 0.0059 0.0026
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0083 0.0446 0.2708
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.008 0.0054
Trypanosoma brucei DNA damage repair protein, putative 0.0026 0.009 0.0253
Echinococcus granulosus dnaJ subfamily B 0.0947 0.5828 0.5814
Schistosoma mansoni cpg binding protein 0.007 0.0368 0.0368
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.008 0.0054
Echinococcus multilocularis dnaJ subfamily B 0.0947 0.5828 0.5814
Loa Loa (eye worm) hypothetical protein 0.01 0.0555 0.3374
Loa Loa (eye worm) hypothetical protein 0.0062 0.0313 0.1897
Mycobacterium ulcerans hypothetical protein 0.0082 0.0443 0.0965
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0024 0.008 0.0123
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0024 0.008 0.0054
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.008 0.0123
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0025 0.0085 0.0053
Echinococcus granulosus L aminoadipate semialdehyde 0.0094 0.0515 0.0484
Treponema pallidum licC protein (licC) 0.0117 0.0661 1
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0266 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0633 0.7572
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0266 0.0234
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0312 0.1876
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0292 0.0603
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0125 0.0709 0.871
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0073 0.0865
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0025 0.0085 0.0085
Loa Loa (eye worm) MBCTL1 0.0061 0.0312 0.1891
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0024 0.008 0.0054
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0443 0.0944
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0024 0.008 0.1127
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0095 0.0313
Loa Loa (eye worm) hypothetical protein 0.01 0.0555 0.3374
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0073 0.0428
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0024 0.00000000096718
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0274 0.0242
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0085 0.0186
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0181 0.2306
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0266 0.0234
Plasmodium falciparum acyl-CoA synthetase 0.0062 0.0313 0.3914
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0277 0.2776
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0025 0.0085 0.0486
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.008 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0443 0.2675
Loa Loa (eye worm) hypothetical protein 0.0061 0.0312 0.1891
Schistosoma mansoni cpg binding protein 0.007 0.0368 0.0368
Echinococcus multilocularis geminin 0.0392 0.2373 0.2348
Loa Loa (eye worm) RecQ helicase 0.0023 0.0073 0.0428
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0101 0.0558 0.3394
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0082 0.0443 0.0965
Loa Loa (eye worm) pyruvate kinase 0.004 0.0181 0.1088
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0082 0.0443 0.0965
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0073 0.102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0274 0.0242
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.008 0.0054
Leishmania major DNA polymerase eta, putative 0.0142 0.0813 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.008 0.0054
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0071 0.0781
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0071 0.0292
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.0457
Echinococcus granulosus pyruvate kinase 0.0021 0.0059 0.0026
Echinococcus multilocularis pyruvate kinase 0.0021 0.0059 0.0026
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0071 0.1278
Trypanosoma brucei chrX additional, unordered contigs 0.0026 0.009 0.0253
Loa Loa (eye worm) hypothetical protein 0.0062 0.0313 0.1897
Leishmania major pyruvate kinase 0.004 0.0181 0.1475
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0094 0.0515 0.3119
Echinococcus granulosus geminin 0.0392 0.2373 0.2348
Schistosoma mansoni ap endonuclease 0.0023 0.0071 0.0071
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0024 0.00000000096718
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0085 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0443 0.0993
Brugia malayi ImpB/MucB/SamB family protein 0.0142 0.0813 0.4943
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0095 0.1323
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0125 0.0709 0.1637
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0082 0.0443 0.0965
Mycobacterium ulcerans DNA polymerase IV 0.0113 0.0633 0.146
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0071 0.0781
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0558 0.0558
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0003 0.0039
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0073 0.0327
Loa Loa (eye worm) oxidoreductase 0.0024 0.008 0.0475
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0181 0.0314
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0633 0.7572
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0024 0.00000000096718
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0073 0.002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0067 0.0344 0.2085
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0073 0.0218
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0071 0.0039
Loa Loa (eye worm) hypothetical protein 0.0062 0.0313 0.1897
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0073 0.102
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0024 0.008 0.0336
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.009 0.0253
Echinococcus granulosus leucine aminopeptidase protein 0.0125 0.0709 0.0678
Loa Loa (eye worm) hypothetical protein 0.0062 0.0313 0.1897
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0056 0.031
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0024
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0024 0.008 0.0048
Trypanosoma cruzi DNA polymerase eta, putative 0.0085 0.0457 0.5609
Schistosoma mansoni hypothetical protein 0.0947 0.5828 0.5828
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0073 0.002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0071 0.0419
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.008 0.0475
Trypanosoma brucei DNA damage repair protein, putative 0.0026 0.009 0.0253
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0033 0.0033
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0024 0.008 0.0024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.0661 0.1559
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0024
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0085 0.0186
Schistosoma mansoni leucine aminopeptidase 0.0025 0.0085 0.0085
Plasmodium vivax pyruvate kinase, putative 0.004 0.0181 0.2551
Echinococcus multilocularis pyruvate kinase 0.004 0.0181 0.0148
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0443 0.0944
Trypanosoma brucei unspecified product 0.0105 0.0587 0.6946
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.00000000036017
Entamoeba histolytica deoxycytidyl transferase, putative 0.0083 0.0446 0.7989
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0073 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0024
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0024 0.008 0.0048
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.0661 0.1559
Echinococcus multilocularis cpg binding protein 0.007 0.0368 0.0336
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0024 0.00000000096718
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0181 0.2577
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0073 0.0218
Plasmodium falciparum DNA repair protein REV1, putative 0.0026 0.009 0.0483
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0266 0.4261
Entamoeba histolytica hypothetical protein 0.0026 0.0095 0.1694
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0085 0.0053
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.008 0.0054
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0073 0.1305
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0085 0.0457 0.6402
Mycobacterium ulcerans hypothetical protein 0.0026 0.009 0.0049
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0095 0.1334
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0101 0.0558 0.6562
Echinococcus multilocularis pyruvate kinase 0.0021 0.0059 0.0026
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.008 0.0457
Entamoeba histolytica acyl-coA synthetase, putative 0.0082 0.0443 0.7932
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0443 0.5006
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0073 0.0806
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0181 0.2196
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0085 0.0053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0071 0.0846
Trypanosoma brucei pyruvate kinase 1 0.004 0.0181 0.1475
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0085 0.0053
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.008 0.0024
Echinococcus multilocularis leucine aminopeptidase protein 0.0125 0.0709 0.0678
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0274 0.0274
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0073 0.0806
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0095 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0633 0.7572
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0024
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0125 0.0709 0.1657
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0633 0.7572
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0125 0.0709 1
Brugia malayi mbt repeat family protein 0.0054 0.0266 0.1591
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.009 0.1077
Loa Loa (eye worm) hypothetical protein 0.0094 0.0515 0.3131
Plasmodium falciparum pyruvate kinase 0.004 0.0181 0.1878
Trypanosoma brucei DNA polymerase IV, putative 0.0113 0.0633 0.7572
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.0085 0.1016
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0181 0.253
Echinococcus multilocularis dual specificity 0.0101 0.0558 0.0527
Schistosoma mansoni terminal deoxycytidyl transferase 0.0083 0.0446 0.0446
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.009 0.0492 0.1122
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0117 0.0661 0.1533
Trypanosoma brucei DNA polymerase IV, putative 0.0105 0.0587 0.6946
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0071 0.003
Echinococcus multilocularis L aminoadipate semialdehyde 0.0094 0.0515 0.0484
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.008 0.0475
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0312 0.028
Trypanosoma brucei unspecified product 0.0057 0.0286 0.289
Echinococcus granulosus pyruvate kinase 0.004 0.0181 0.0148
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0181 0.1475
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0085 0.0186
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0058 0.0025
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0085 0.0053
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0181 0.1071
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0073 0.004
Mycobacterium ulcerans leucyl aminopeptidase 0.0125 0.0709 0.1657
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0443 0.2675
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0003 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0274 0.0274
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0181 0.0261
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0024 0.008 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0443 0.2675
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0443 0.5006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0633 0.7778
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0125 0.0709 0.871
Schistosoma mansoni hypothetical protein 0.0332 0.2 0.2
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0633 0.7572
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0083 0.0446 0.0415
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0181 0.2306
Entamoeba histolytica protein kinase, putative 0.0101 0.0558 1
Entamoeba histolytica protein kinase, putative 0.0101 0.0558 1
Schistosoma mansoni microtubule-associated protein tau 0.1617 1 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0024 0.008 0.0024
Echinococcus multilocularis microtubule associated protein 2 0.1617 1 1
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0059 0.0821
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.0475
Plasmodium vivax DNA repair protein REV1, putative 0.0026 0.009 0.1271
Loa Loa (eye worm) hypothetical protein 0.0056 0.0277 0.1677
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0274 0.1641
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0332 0.3516
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0443 0.7932
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0003 0.0003
Echinococcus granulosus pyruvate kinase 0.0021 0.0059 0.0026
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0025 0.0085 0.0486
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.0085 0.1016
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0095 0.0552
Plasmodium vivax acyl-CoA synthetase, putative 0.0062 0.0313 0.4418
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0292 0.0603
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0073 0.004
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0024 0.008 0.1442
Onchocerca volvulus 0.0067 0.0344 0.6062
Leishmania major DNA damage repair protein, putative 0.0026 0.009 0.0253
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0332 0.3516
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0062 0.0313 0.0628
Brugia malayi mbt repeat family protein 0.0054 0.0266 0.1591
Trypanosoma brucei DNA polymerase eta, putative 0.0142 0.0813 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0443 0.5006
Toxoplasma gondii histone lysine methyltransferase SET1 0.0126 0.0715 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.008 0.0054
Mycobacterium ulcerans pyruvate kinase 0.004 0.0181 0.0284
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.0475
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.0558 0.6853
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0633 0.7778
Toxoplasma gondii exonuclease III APE 0.0023 0.0071 0.0998
Echinococcus granulosus pyruvate kinase 0.004 0.0181 0.0148
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0292 0.0603
Onchocerca volvulus 0.0094 0.0515 1
Schistosoma mansoni hypothetical protein 0.0392 0.2373 0.2373
Entamoeba histolytica hypothetical protein 0.0101 0.0558 1
Echinococcus multilocularis pyruvate kinase 0.004 0.0181 0.0148
Trypanosoma cruzi DNA polymerase eta, putative 0.0142 0.0813 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0024 0.008 0.0457
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0274 0.0274
Leishmania major DNA polymerase kappa, putative 0.0026 0.009 0.0253
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0117 0.0661 0.9256
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0059 0.0828
Mycobacterium tuberculosis Conserved hypothetical protein 0.0083 0.0446 0.1001
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0082 0.0443 0.0993
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0025 0.0085 0.0503
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0073 0.041
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0024 0.008 0.1127
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.0558 0.6853
Loa Loa (eye worm) pyruvate kinase 0.004 0.0181 0.1088
Leishmania major pyruvate kinase 0.004 0.0181 0.1475
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0095 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0633 0.7572
Schistosoma mansoni DNA helicase recq1 0.0023 0.0073 0.0073
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.008 0.0959
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0083 0.0446 0.0446
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0274 0.1657
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0024
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0095 0.1393
Loa Loa (eye worm) hypothetical protein 0.0062 0.0313 0.1897
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0274 0.1639 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0633 0.7572
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0443 0.7932
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0071 0.1007
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0181 0.2196
Onchocerca volvulus 0.0082 0.0443 0.8334
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0024
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0312 0.028
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.009 0.0253
Echinococcus granulosus dual specificity 0.0101 0.0558 0.0527
Mycobacterium ulcerans hypothetical protein 0.0117 0.0661 0.1533
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.009 0.0492 0.5675
Trypanosoma cruzi DNA damage repair protein, putative 0.0026 0.009 0.1077
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.008 0.0931
Trypanosoma brucei DNA polymerase IV, putative 0.0113 0.0633 0.7572
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0025 0.0085 0.0503
Brugia malayi polk-prov protein 0.0056 0.0277 0.1662
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0181 0.2577
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0083 0.0446 0.0415
Plasmodium falciparum M17 leucyl aminopeptidase 0.0125 0.0709 1
Chlamydia trachomatis cytosol aminopeptidase 0.0125 0.0709 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0024 0.008 0.0024
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0641 0.3919 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.0085 0.0186
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0024 0.00000000096718
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0443 0.0965
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0633 0.7572
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0062 0.0313 0.3559
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0105 0.0624
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0274 0.0242
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0641 0.3919 1
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0105 0.1879
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0443 0.0965
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0024 0.008 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.0633 0.7572
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0073 0.041
Brugia malayi CXXC zinc finger family protein 0.0067 0.0344 0.2071
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0095 0.006
Schistosoma mansoni DNA polymerase eta 0.0142 0.0813 0.0813
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.0457
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0633 0.7778
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0095 0.1323
Schistosoma mansoni pyruvate kinase 0.004 0.0181 0.0181
Schistosoma mansoni hypothetical protein 0.0392 0.2373 0.2373
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0274 0.0242
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0026 0.009 0.1261
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0266 0.0234
Trypanosoma brucei unspecified product 0.0057 0.0286 0.289
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.008 0.0959
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0073 0.041
Plasmodium vivax acetyl-CoA synthetase, putative 0.0024 0.008 0.1136
Leishmania major DNA polymerase eta, putative 0.0085 0.0457 0.5203
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0024 0.00000000096718
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0641 0.3919 1
Echinococcus granulosus cpg binding protein 0.007 0.0368 0.0336
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0312 0.0312
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.0085 0.0186
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0024 0.008 0.0123
Mycobacterium ulcerans acetyl-CoA synthetase 0.0024 0.008 0.0024
Brugia malayi Protein kinase domain containing protein 0.0101 0.0558 0.3382
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0058 0.0338
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0101 0.0558 0.6562
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0095 0.006
Echinococcus granulosus dna polymerase kappa 0.0113 0.0633 0.0602
Schistosoma mansoni ap endonuclease 0.0023 0.0071 0.0071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0292 0.0603
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.009 0.1077
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0095 0.0313
Echinococcus granulosus bloom syndrome protein 0.0023 0.0073 0.004
Schistosoma mansoni cpg binding protein 0.0067 0.0344 0.0344
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0113 0.0633 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0024
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0181 0.2306
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0217 0.1282 0.1253
Loa Loa (eye worm) hypothetical protein 0.0054 0.0266 0.1607
Echinococcus multilocularis pyruvate kinase 0.0032 0.0128 0.0095
Trypanosoma cruzi DNA polymerase kappa, putative 0.0113 0.0633 0.7778
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.008 0.0959
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0071 0.0195
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0024 0.008 0.0024
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0641 0.3919 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.0457
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.0558 1
Schistosoma mansoni pyruvate kinase 0.0021 0.0059 0.0059
Brugia malayi ImpB/MucB/SamB family protein 0.0083 0.0446 0.2695
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0125 0.0709 0.8591
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0062 0.0313 0.0657
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0003 0.0039
Chlamydia trachomatis pyruvate kinase 0.004 0.0181 0.1404
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.008 0.0931
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.008 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0492 0.5675

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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