Detailed information for compound 71511

Basic information

Technical information
  • TDR Targets ID: 71511
  • Name: N-[4-bromo-2-(1,1,1,3,3,3-hexafluoro-2-hydrox ypropan-2-yl)naphthalen-1-yl]acetamide
  • MW: 430.14 | Formula: C15H10BrF6NO2
  • H donors: 2 H acceptors: 2 LogP: 4.79 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1c2ccccc2c(cc1C(C(F)(F)F)(C(F)(F)F)O)Br
  • InChi: 1S/C15H10BrF6NO2/c1-7(24)23-12-9-5-3-2-4-8(9)11(16)6-10(12)13(25,14(17,18)19)15(20,21)22/h2-6,25H,1H3,(H,23,24)
  • InChiKey: MLWUFYIOPMICQS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-bromo-2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1-naphthyl]acetamide
  • N-[4-bromo-2-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2-yl)naphthalen-1-yl]ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 11 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0225 0.0276 0.0276
Echinococcus multilocularis Niemann Pick C1 protein 0.0713 0.0927 0.0927
Mycobacterium tuberculosis Probable lipase LipE 0.0147 0.0171 0.1396
Loa Loa (eye worm) hypothetical protein 0.003 0.0016 0.004
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.0082 0.0211
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0223 0.057
Toxoplasma gondii ATPase, AAA family protein 0.0051 0.0043 0.2515
Echinococcus granulosus Niemann Pick C1 protein 0.1019 0.1336 0.342
Leishmania major DNA polymerase eta, putative 0.0039 0.0028 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0016 0.004
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0044 0.0355
Trypanosoma cruzi N-myristoyl transferase, putative 0.2945 0.3906 1
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.2945 0.3906 1
Loa Loa (eye worm) hypothetical protein 0.1435 0.1891 0.4841
Echinococcus granulosus dna polymerase kappa 0.0039 0.0028 0.0072
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0055 0.0049 0.0401
Loa Loa (eye worm) hypothetical protein 0.0147 0.0171 0.0439
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0064 0.0061 0.3564
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0171 0.0439
Trichomonas vaginalis antibiotic synthetase, putative 0.0064 0.0061 0.0156
Onchocerca volvulus 0.0043 0.0033 0.0908
Echinococcus multilocularis geminin 0.038 0.0483 0.0483
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0147 0.0171 0.1396
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0022 0.1265
Schistosoma mansoni hypothetical protein 0.038 0.0483 0.1237
Entamoeba histolytica hypothetical protein 0.0628 0.0813 0.2082
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0028 0.105
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0051 0.0043 0.011
Echinococcus granulosus lamin dm0 0.0058 0.0052 0.0134
Loa Loa (eye worm) hypothetical protein 0.0039 0.0028 0.0072
Onchocerca volvulus 0.0058 0.0052 0.1433
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0333 0.0853
Mycobacterium ulcerans acetyl-CoA synthetase 0.0064 0.0061 0.2286
Echinococcus multilocularis protein dispatched 1 0.0349 0.0442 0.0442
Brugia malayi latrophilin 2 splice variant baaae 0.0486 0.0624 0.1598
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0163 0.0193 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Plasmodium vivax patched family protein, putative 0.0043 0.0033 0.0085
Schistosoma mansoni hypothetical protein 0.0225 0.0276 0.0706
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0061 0.2286
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0064 0.0061 0.0156
Loa Loa (eye worm) hypothetical protein 0.0102 0.0112 0.0286
Schistosoma mansoni Smad4 0.0041 0.003 0.0077
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.0333 0.0853
Loa Loa (eye worm) hypothetical protein 0.0078 0.0079 0.0203
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0064 0.0061 0.1947
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0147 0.0171 0.0439
Schistosoma mansoni hypothetical protein 0.0293 0.0366 0.0938
Brugia malayi hypothetical protein 0.1435 0.1891 0.4841
Loa Loa (eye worm) hypothetical protein 0.0147 0.0171 0.0439
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0218 0.0267 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.0256 0.0656
Loa Loa (eye worm) hypothetical protein 0.0147 0.0171 0.0439
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.003 0.0077
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0079 0.2416
Loa Loa (eye worm) nuclear factor I 0.0023 0.0006 0.0015
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0051 0.0043 0.1245
Mycobacterium ulcerans acyl-CoA synthetase 0.0218 0.0267 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0016 0.0916
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0218 0.0267 1
Brugia malayi AMP-binding enzyme family protein 0.0064 0.0061 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0043 0.011
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.021 0.0538
Brugia malayi MAP kinase sur-1 0.0056 0.0051 0.013
Brugia malayi isocitrate dehydrogenase 0.0035 0.0022 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0012 0.003
Toxoplasma gondii LsmAD domain-containing protein 0.008 0.0082 0.4801
Entamoeba histolytica acyl-CoA synthetase, putative 0.0218 0.0267 0.0684
Brugia malayi AMP-binding enzyme family protein 0.0064 0.0061 0.0157
Mycobacterium ulcerans esterase/lipase LipP 0.0147 0.0171 0.6416
Onchocerca volvulus 0.0068 0.0066 0.1813
Treponema pallidum DNA ligase (lig) 0.0051 0.0043 0.5428
Onchocerca volvulus 0.0043 0.0033 0.0908
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0051 0.0051
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0064 0.0061 0.0156
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0051 0.0043 0.011
Onchocerca volvulus 0.0218 0.0267 0.7294
Schistosoma mansoni hypothetical protein 0.0225 0.0276 0.0706
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.0082 0.0211
Schistosoma mansoni microtubule-associated protein tau 0.1374 0.181 0.4634
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0938 0.1227 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0079 0.0203
Loa Loa (eye worm) hypothetical protein 0.0051 0.0043 0.0111
Mycobacterium tuberculosis Probable esterase LipL 0.0147 0.0171 0.1396
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Echinococcus multilocularis Smad4 0.0041 0.003 0.003
Echinococcus multilocularis sterol regulatory element binding protein 0.0306 0.0384 0.0384
Echinococcus granulosus replication factor c subunit 1 0.0051 0.0043 0.0111
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0061 0.2286
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0064 0.0061 0.0498
Toxoplasma gondii hypothetical protein 0.0043 0.0033 0.1936
Loa Loa (eye worm) hypothetical protein 0.0147 0.0171 0.0439
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0016 0.004
Loa Loa (eye worm) patched family protein 0.0043 0.0033 0.0085
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0064 0.0061 0.0498
Mycobacterium ulcerans beta-lactamase 0.0147 0.0171 0.6416
Loa Loa (eye worm) hypothetical protein 0.0051 0.0043 0.0111
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0058 0.2159
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.003 0.0077
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0022 0.1265
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.021 0.0538
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0051 0.0043 0.1614
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0064 0.0061 0.2286
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0022 0.0056
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0016 0.0016
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0051 0.013
Loa Loa (eye worm) hypothetical protein 0.0101 0.0111 0.0284
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.021 0.0538
Entamoeba histolytica hypothetical protein 0.0628 0.0813 0.2082
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.003 0.0077
Echinococcus granulosus nibrin 0.0051 0.0043 0.0111
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0064 0.0061 0.0156
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.2945 0.3906 1
Brugia malayi MH1 domain containing protein 0.0023 0.0006 0.0015
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Brugia malayi hypothetical protein 0.0052 0.0044 0.0114
Loa Loa (eye worm) hypothetical protein 0.0163 0.0193 0.0495
Mycobacterium ulcerans acyl-CoA synthetase 0.0218 0.0267 1
Echinococcus multilocularis Niemann Pick C1 protein 0.1019 0.1336 0.1336
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0012 0.003
Echinococcus multilocularis nibrin 0.0051 0.0043 0.0043
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0064 0.0061 0.1947
Onchocerca volvulus 0.0058 0.0052 0.1433
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Brugia malayi hypothetical protein 0.0043 0.0033 0.0085
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0028 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0051 0.0051
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0022 0.0055
Loa Loa (eye worm) hypothetical protein 0.0028 0.0013 0.0032
Mycobacterium ulcerans hypothetical protein 0.0218 0.0267 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0293 0.0366 0.0938
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Loa Loa (eye worm) patched family protein 0.0043 0.0033 0.0085
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0051 0.0043 0.5428
Schistosoma mansoni hypothetical protein 0.0225 0.0276 0.0706
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0064 0.0061 0.0156
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0064 0.0061 0.0498
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0061 0.2286
Schistosoma mansoni survival motor neuron protein 0.0293 0.0366 0.0938
Giardia lamblia Replication factor C, subunit 1 0.0051 0.0043 0.011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0218 0.0267 0.2176
Echinococcus granulosus survival motor neuron protein 1 0.1435 0.1891 0.4841
Entamoeba histolytica hypothetical protein 0.0628 0.0813 0.2082
Brugia malayi MH2 domain containing protein 0.0041 0.003 0.0077
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0064 0.0061 0.0498
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.003 0.0077
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0022 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0218 0.0267 0.0684
Loa Loa (eye worm) hypothetical protein 0.008 0.0082 0.0211
Leishmania major 4-coumarate:coa ligase-like protein 0.0218 0.0267 0.0684
Brugia malayi MH1 domain containing protein 0.0041 0.003 0.0077
Onchocerca volvulus 0.0064 0.0061 0.167
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0058 0.3365
Schistosoma mansoni hypothetical protein 0.0295 0.0369 0.0946
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0013 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0051 0.013
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0028 0.0072
Schistosoma mansoni hypothetical protein 0.0628 0.0813 0.2083
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0064 0.0061 0.0157
Plasmodium falciparum acyl-CoA synthetase 0.0163 0.0193 0.0495
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0043 0.011
Plasmodium vivax acetyl-CoA synthetase, putative 0.0064 0.0061 0.0156
Brugia malayi Niemann-Pick C1 protein precursor 0.0713 0.0927 0.2374
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Loa Loa (eye worm) N-myristoyltransferase 2 0.2945 0.3906 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0022 0.0022
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0061 0.0498
Schistosoma mansoni lamin 0.0058 0.0052 0.0134
Echinococcus granulosus Protein patched homolog 1 0.0306 0.0384 0.0983
Brugia malayi CHE-14 protein 0.0306 0.0384 0.0983
Loa Loa (eye worm) hypothetical protein 0.0064 0.0061 0.0157
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.0082 0.0211
Loa Loa (eye worm) latrophilin receptor protein 2 0.0225 0.0276 0.0706
Onchocerca volvulus Protein patched homolog 0.0043 0.0033 0.0908
Leishmania major DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0028 0.0072
Onchocerca volvulus 0.0043 0.0033 0.0908
Loa Loa (eye worm) transcription factor SMAD2 0.0602 0.0779 0.1994
Brugia malayi AMP-binding enzyme family protein 0.0064 0.0061 0.0157
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0064 0.0061 0.0157
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0051 0.013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0029
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0061 0.0498
Echinococcus multilocularis survival motor neuron protein 1 0.1435 0.1891 0.1891
Loa Loa (eye worm) hypothetical protein 0.0051 0.0043 0.0111
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0628 0.0813 0.2083
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0028 0.0228
Brugia malayi Pax transcription activation domain interacting protein 0.0051 0.0043 0.0111
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0225 0.0276 0.0706
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0061 0.0498
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0051 0.013
Onchocerca volvulus 0.0064 0.0061 0.167
Toxoplasma gondii patched family protein 0.0043 0.0033 0.1936
Trichomonas vaginalis antibiotic synthetase, putative 0.0064 0.0061 0.0156
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0023 0.0023
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0064 0.0061 0.2286
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0064 0.0061 0.2286
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0064 0.0061 0.2286
Loa Loa (eye worm) hypothetical protein 0.0713 0.0927 0.2374
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Onchocerca volvulus 0.0064 0.0061 0.167
Leishmania major hypothetical protein, conserved 0.008 0.0082 0.0211
Mycobacterium tuberculosis Probable lipase LipD 0.0147 0.0171 0.1396
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0079 0.0203
Leishmania major acetyl-CoA synthetase, putative 0.0064 0.0061 0.0156
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0218 0.0267 1
Onchocerca volvulus 0.0051 0.0043 0.1179
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0333 0.0853
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0154 0.0182 0.1479
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0023 0.006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0022 0.0022
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0051 0.013
Schistosoma mansoni topbp1 0.0051 0.0043 0.0111
Echinococcus granulosus intermediate filament protein 0.0058 0.0052 0.0134
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0051 0.013
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0064 0.0061 0.0498
Brugia malayi Pre-SET motif family protein 0.021 0.0256 0.0656
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0051 0.0043 0.0111
Loa Loa (eye worm) hypothetical protein 0.0102 0.0112 0.0286
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0022 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0177 0.0453
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0079 0.4633
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0043 0.011
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0064 0.0061 0.0157
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0028 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0064 0.0061 0.0156
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0014 0.0037
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0051 0.2961
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Mycobacterium tuberculosis Conserved protein 0.0147 0.0171 0.1396
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0724 0.0942 0.2412
Leishmania major 4-coumarate:coa ligase-like protein 0.0218 0.0267 0.0684
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0079 0.0203
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0051 0.013
Echinococcus multilocularis replication factor c subunit 1 0.0051 0.0043 0.0043
Brugia malayi hypothetical protein 0.0051 0.0043 0.0111
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0079 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.003 0.003
Mycobacterium leprae conserved hypothetical protein 0.0147 0.0171 0.6259
Brugia malayi beta-lactamase 0.0147 0.0171 0.0439
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0147 0.0171 0.1396
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0163 0.0193 0.1576
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0061 0.2286
Loa Loa (eye worm) hypothetical protein 0.0218 0.0267 0.0684
Onchocerca volvulus 0.0239 0.0295 0.8053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0177 0.0453
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0028 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0333 0.0853
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0028 0.0072
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0028 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0043 0.011
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0079 0.2416
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.021 0.0538
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.2945 0.3906 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Brugia malayi Pre-SET motif family protein 0.003 0.0016 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0061 0.2286
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0028 0.0228
Trypanosoma brucei N-myristoyltransferase 0.2945 0.3906 1
Schistosoma mansoni hypothetical protein 0.0036 0.0023 0.006
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0017 0.0043
Echinococcus granulosus GPCR family 2 0.0225 0.0276 0.0706
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Loa Loa (eye worm) hypothetical protein 0.0147 0.0171 0.0439
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0628 0.0813 0.0813
Entamoeba histolytica hypothetical protein 0.0051 0.0043 0.011
Echinococcus granulosus microtubule associated protein 2 0.1374 0.181 0.4634
Toxoplasma gondii patched family protein 0.0043 0.0033 0.1936
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0016 0.004
Loa Loa (eye worm) hypothetical protein 0.0163 0.0193 0.0495
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0306 0.0384 0.0983
Brugia malayi MH2 domain containing protein 0.0041 0.003 0.0077
Schistosoma mansoni smad1 5 8 and 0.0041 0.003 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0051 0.013
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0051 0.013
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0044 0.0112
Mycobacterium ulcerans lipase LipD 0.0147 0.0171 0.6416
Onchocerca volvulus 0.0293 0.0366 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0028 0.0072
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0147 0.0171 0.0439
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Onchocerca volvulus 0.0043 0.0033 0.0908
Plasmodium vivax replication factor C subunit 1, putative 0.0051 0.0043 0.011
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0011 0.0029
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0064 0.0061 0.0498
Echinococcus multilocularis protein patched 0.0306 0.0384 0.0384
Entamoeba histolytica acyl-CoA synthetase, putative 0.0218 0.0267 0.0684
Schistosoma mansoni acetyl-CoA synthetase 0.0064 0.0061 0.0157
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0079 1
Brugia malayi beta-lactamase family protein 0.0147 0.0171 0.0439
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0022 0.0022
Schistosoma mansoni topbp1 0.0051 0.0043 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0306 0.0384 0.0983
Loa Loa (eye worm) hypothetical protein 0.0051 0.0043 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.0384 0.0983
Plasmodium vivax ataxin-2 like protein, putative 0.008 0.0082 0.0211
Schistosoma mansoni hypothetical protein 0.0295 0.0369 0.0946
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Loa Loa (eye worm) hypothetical protein 0.0375 0.0476 0.1219
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Echinococcus multilocularis lamin 0.0058 0.0052 0.0052
Brugia malayi Myosin head containing protein 0.0043 0.0033 0.0085
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.021 0.0538
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0000095379 0.0000095379
Brugia malayi hypothetical protein 0.008 0.0082 0.0211
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0051 0.013
Plasmodium falciparum replication factor C subunit 1, putative 0.0051 0.0043 0.011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0163 0.0193 0.724
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0154 0.0182 0.1479
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Brugia malayi protein C24B5.3 0.0043 0.0033 0.0085
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0051 0.0043 0.011
Brugia malayi Smad1 0.0041 0.003 0.0077
Trypanosoma brucei unspecified product 0.0027 0.0012 0.003
Plasmodium vivax SET domain protein, putative 0.003 0.0016 0.004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0016 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Echinococcus granulosus dna polymerase eta 0.0039 0.0028 0.0072
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0022 0.0177
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0051 0.013
Echinococcus multilocularis dna polymerase eta 0.0039 0.0028 0.0028
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0064 0.0061 0.2286
Loa Loa (eye worm) patched family protein 0.0043 0.0033 0.0085
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0051 0.013
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0051 0.0043 0.011
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.0082 0.0211
Schistosoma mansoni patched 1 0.0306 0.0384 0.0983
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0017 0.0043
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0064 0.0061 0.2286
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0147 0.0171 0.6416
Schistosoma mansoni chromosome transmission fidelity factor 0.0051 0.0043 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Plasmodium falciparum lipid/sterol:H+ symporter 0.0043 0.0033 0.0085
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Trichomonas vaginalis N-myristoyl transferase, putative 0.1935 0.2558 0.6549
Brugia malayi AMP-binding enzyme family protein 0.0218 0.0267 0.0684
Echinococcus multilocularis lamin dm0 0.0058 0.0052 0.0052
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.003 0.003
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0218 0.0267 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0051 0.013
Echinococcus granulosus tumor protein p63 0.0693 0.0901 0.2306
Entamoeba histolytica hypothetical protein 0.0628 0.0813 0.2082
Giardia lamblia DINP protein human, muc B family 0.0039 0.0028 0.0072
Echinococcus granulosus sterol regulatory element binding protein 0.0306 0.0384 0.0983
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0064 0.0061 0.0498
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0713 0.0927 0.2374
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0058 0.0148
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0333 0.0853
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0187 0.0225 0.6157
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0028 0.0072
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0064 0.0061 0.0156
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0171 0.0439
Trichomonas vaginalis replication factor C large subunit, putative 0.0051 0.0043 0.011
Echinococcus multilocularis musashi 0.0058 0.0052 0.0052
Toxoplasma gondii patched family protein 0.0043 0.0033 0.1936
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0711 0.0925 0.2367
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0051 0.0043 0.2515
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0061 0.2286
Loa Loa (eye worm) hypothetical protein 0.0051 0.0043 0.0111
Onchocerca volvulus 0.0043 0.0033 0.0908
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0333 0.0853
Trypanosoma cruzi FHA domain containing protein, putative 0.0051 0.0043 0.011
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0022 0.0022
Brugia malayi Patched protein homolog 1 0.0043 0.0033 0.0085
Mycobacterium tuberculosis Probable hydrolase 0.0147 0.0171 0.1396
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0171 0.0439
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0028 0.0072
Brugia malayi protein C24B5.3 0.0043 0.0033 0.0085
Leishmania major hypothetical protein, conserved 0.0147 0.0171 0.0439
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0022 0.0055
Schistosoma mansoni hypothetical protein 0.0295 0.0369 0.0946
Loa Loa (eye worm) hypothetical protein 0.0102 0.0112 0.0286
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0013 0.0032
Leishmania major N-myristoyl transferase, putative 0.2945 0.3906 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0028 0.0028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0154 0.0182 0.1479
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0147 0.0171 0.1396
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0028 0.0072
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0079 0.0203
Schistosoma mansoni smad 0.0041 0.003 0.0077
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0051 0.013
Echinococcus multilocularis tumor protein p63 0.0693 0.0901 0.0901
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0061 0.2286
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0064 0.0061 0.2286
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0051 0.013
Brugia malayi intermediate filament protein 0.0058 0.0052 0.0134
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.021 0.0538
Brugia malayi hypothetical protein 0.0043 0.0033 0.0085
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0052 0.0134
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0064 0.0061 0.2286
Onchocerca volvulus 0.0101 0.0111 0.303
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0711 0.0925 0.2367
Toxoplasma gondii patched family protein 0.0043 0.0033 0.1936
Loa Loa (eye worm) hypothetical protein 0.0163 0.0193 0.0495
Schistosoma mansoni intermediate filament proteins 0.0058 0.0052 0.0134
Toxoplasma gondii hypothetical protein 0.0102 0.0112 0.6515
Brugia malayi Patched related family protein 12 0.0043 0.0033 0.0085
Loa Loa (eye worm) hypothetical protein 0.0163 0.0193 0.0495
Mycobacterium tuberculosis Conserved protein 0.0147 0.0171 0.1396
Loa Loa (eye worm) beta-lactamase 0.0147 0.0171 0.0439
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0028 0.0072
Mycobacterium tuberculosis Conserved protein 0.0147 0.0171 0.1396
Schistosoma mansoni transcription factor LCR-F1 0.0628 0.0813 0.2083
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0044 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0043 0.011
Toxoplasma gondii hypothetical protein 0.0027 0.0011 0.0657
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.003 0.0077
Schistosoma mansoni smad1 5 8 and 0.0041 0.003 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0225 0.0276 0.0706
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0016 0.004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0064 0.0061 0.0157
Plasmodium vivax acyl-CoA synthetase, putative 0.0163 0.0193 0.0495
Onchocerca volvulus 0.0147 0.0171 0.4681
Brugia malayi beta-lactamase family protein 0.0147 0.0171 0.0439
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0064 0.0061 0.0157
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0064 0.0061 0.0156
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0218 0.0267 0.2176
Trichomonas vaginalis set domain proteins, putative 0.0239 0.0295 0.0755
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0058 0.2159
Mycobacterium ulcerans acyl-CoA synthetase 0.0218 0.0267 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0044 0.0355
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Brugia malayi MH2 domain containing protein 0.0602 0.0779 0.1994
Onchocerca volvulus 0.0147 0.0171 0.4681
Brugia malayi Probable ClpP-like protease 0.0078 0.0079 0.0203
Brugia malayi Calcitonin receptor-like protein seb-1 0.0711 0.0925 0.2367
Brugia malayi hypothetical protein 0.0043 0.0033 0.0085
Brugia malayi Patched related family protein 10 0.0043 0.0033 0.0085
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0028 0.0072
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Loa Loa (eye worm) patched family protein 0.0043 0.0033 0.0085
Entamoeba histolytica acyl-coA synthetase, putative 0.0218 0.0267 0.0684
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Trypanosoma brucei protein kinase, putative 0.0056 0.0051 0.013
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0022 0.0055
Brugia malayi hypothetical protein 0.0043 0.0033 0.0085
Echinococcus multilocularis expressed conserved protein 0.067 0.087 0.087
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0051 0.013
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0218 0.0267 1
Plasmodium vivax hypothetical protein, conserved 0.0147 0.0171 0.0439
Onchocerca volvulus 0.0043 0.0033 0.0908
Brugia malayi MH1 domain containing protein 0.0041 0.003 0.0077
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0079 0.2973
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0028 0.0072
Trypanosoma brucei N-myristoyl transferase, putative 0.2945 0.3906 1
Loa Loa (eye worm) hypothetical protein 0.0225 0.0276 0.0706
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0171 0.0439
Brugia malayi MH1 domain containing protein 0.0023 0.0006 0.0015
Echinococcus granulosus smad 0.0041 0.003 0.0077
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Brugia malayi hypothetical protein 0.0628 0.0813 0.2083
Loa Loa (eye worm) hypothetical protein 0.0711 0.0925 0.2367
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.0171 0.0439
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0011 0.0029
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0079 0.0079
Echinococcus granulosus lamin 0.0058 0.0052 0.0134
Brugia malayi DKFZp564C0469 protein 0.0051 0.0043 0.0111
Schistosoma mansoni N-myristoyltransferase 0.2945 0.3906 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Echinococcus multilocularis GPCR, family 2 0.0225 0.0276 0.0276
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0102 0.0112 0.0286
Schistosoma mansoni lamin 0.0058 0.0052 0.0134
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0058 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.0064 0.0061 0.2286
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0177 0.0177
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0064 0.0061 0.0498
Loa Loa (eye worm) patched family protein 0.0043 0.0033 0.0085
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0079 0.2664
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0016 0.004
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0177 0.0453
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Brugia malayi Latrophilin receptor protein 2 0.0225 0.0276 0.0706
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0058 0.0148
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0079 0.2973
Schistosoma mansoni DNA polymerase eta 0.0039 0.0028 0.0072
Loa Loa (eye worm) hypothetical protein 0.0064 0.0061 0.0157
Brugia malayi topoisomerase 0.0051 0.0043 0.0111
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0151 0.0177 0.0453
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0022 0.0055
Onchocerca volvulus Protein patched homolog 0.0043 0.0033 0.0908
Trypanosoma brucei unspecified product 0.0039 0.0028 0.0072
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0022 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0058 0.2159
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0163 0.0193 0.0495
Loa Loa (eye worm) hypothetical protein 0.0058 0.0052 0.0134
Mycobacterium leprae Probable lipase LipE 0.0147 0.0171 0.6259
Echinococcus granulosus beta LACTamase domain containing family member 0.0147 0.0171 0.0439
Schistosoma mansoni smad1 5 8 and 0.0041 0.003 0.0077
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0064 0.0061 0.0156
Schistosoma mansoni hypothetical protein 0.0486 0.0624 0.1598
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Toxoplasma gondii propionate-CoA ligase 0.0064 0.0061 0.3564
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0218 0.0267 1
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Brugia malayi hypothetical protein 0.0051 0.0043 0.0111
Loa Loa (eye worm) MH2 domain-containing protein 0.0602 0.0779 0.1994
Brugia malayi Patched related family protein 4 0.0043 0.0033 0.0085
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0028 0.0072
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0022 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Loa Loa (eye worm) hypothetical protein 0.0486 0.0624 0.1598
Echinococcus multilocularis beta LACTamase domain containing family member 0.0147 0.0171 0.0171
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0011 0.1418
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0043 0.011
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0225 0.0276 0.0276
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0171 0.0439
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Mycobacterium ulcerans hypothetical protein 0.0147 0.0171 0.6416
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.021 0.5738
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0223 0.057
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0225 0.0276 0.0706
Brugia malayi AMP-binding enzyme family protein 0.0218 0.0267 0.0684
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.021 0.0538
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0022 0.0055
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0064 0.0061 0.0061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0154 0.0182 0.1479
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0177 0.0453
Echinococcus multilocularis microtubule associated protein 2 0.1374 0.181 0.181
Trypanosoma brucei PAB1-binding protein , putative 0.008 0.0082 0.0211
Echinococcus granulosus Smad4 0.0041 0.003 0.0077
Echinococcus granulosus geminin 0.038 0.0483 0.1237
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0064 0.0061 0.0156
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.0333 0.0853
Echinococcus multilocularis smad 0.0041 0.003 0.003
Brugia malayi Patched family protein 0.0043 0.0033 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0171 0.0439
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0171 0.0439
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0051 0.0043 0.011
Onchocerca volvulus 0.003 0.0016 0.0431
Onchocerca volvulus 0.0043 0.0033 0.0908
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0028 0.105
Brugia malayi N-myristoyltransferase 2 0.2945 0.3906 1
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.2945 0.3906 0.3906
Trichomonas vaginalis esterase, putative 0.0147 0.0171 0.0439
Schistosoma mansoni hypothetical protein 0.0225 0.0276 0.0706
Loa Loa (eye worm) hypothetical protein 0.0051 0.0043 0.0111
Trichomonas vaginalis N-myristoyl transferase, putative 0.2945 0.3906 1
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0333 0.0853
Schistosoma mansoni DNA ligase IV 0.0051 0.0043 0.0111
Brugia malayi N-terminal motif family protein 0.0187 0.0225 0.0577
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0151 0.0177 0.0453
Onchocerca volvulus 0.0147 0.0171 0.4681
Trypanosoma cruzi N-myristoyl transferase, putative 0.2945 0.3906 1
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0064 0.0061 0.1947
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0052 0.0134
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0058 0.047
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0043 0.011
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0044 0.1264
Loa Loa (eye worm) hypothetical protein 0.0218 0.0267 0.0684
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0058 0.0058
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0028 0.0072
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.2945 0.3906 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0177 0.0177
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0058 0.0148
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0028 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0177 0.0453
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0079 0.4633
Toxoplasma gondii ABC1 family protein 0.0147 0.0171 1
Schistosoma mansoni hypothetical protein 0.0295 0.0369 0.0946
Echinococcus granulosus expressed conserved protein 0.067 0.087 0.2227
Echinococcus granulosus Niemann Pick C1 protein 0.0713 0.0927 0.2374
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0171 0.0439
Leishmania major acetyl-CoA synthetase, putative 0.0064 0.0061 0.0156
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0022 0.0055
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0111 0.0284
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0051 0.0043 0.011
Loa Loa (eye worm) hypothetical protein 0.0187 0.0225 0.0577
Brugia malayi AMP-binding enzyme family protein 0.0064 0.0061 0.0157
Trypanosoma brucei unspecified product 0.0027 0.0012 0.003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0147 0.0171 0.0439
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0022 0.0056
Giardia lamblia CDC72 0.2945 0.3906 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0218 0.0267 0.0684
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0052 0.0134
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0171 0.0439
Loa Loa (eye worm) Smad1 0.0041 0.003 0.0077
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.0085
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0051 0.0043 0.011
Schistosoma mansoni hypothetical protein 0.038 0.0483 0.1237
Loa Loa (eye worm) hypothetical protein 0.0218 0.0267 0.0684
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0064 0.0061 0.3564
Loa Loa (eye worm) oxidoreductase 0.0064 0.0061 0.0157

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 5.31 uM Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17 ChEMBL. 12729655
EC50 (binding) = 5.31 uM Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17 ChEMBL. 12729655

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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